file PSI-MOD.obo

1.2 30:05:2014 00:48 John S. Garavelli FormulaOBO.PL PSI-MOD-slim subset of protein modifications DeltaMass-label Label from MS DeltaMass OMSSA-label Short label from OMSSA PSI-MOD-alternate Alternate name curated by PSI-MOD PSI-MOD-label Short label curated by PSI-MOD PSI-MS-label Agreed label from MS community RESID-alternate Alternate name from RESID RESID-misnomer Misnomer tagged alternate name from RESID RESID-name Name from RESID RESID-systematic Systematic name from RESID UniMod-alternate Alternate name from UniMod UniMod-description Description (full_name) from UniMod UniMod-interim Interim label from UniMod UniProt-feature Protein feature description from UniProtKB PSI-MOD PSI-MOD version: 1.013.0 RESID release: 75.00 ISO-8601 date: 2014-01-28 14:22Z Annotation note 1 - "[PSI-MOD:ref]" has been replaced by PubMed:18688235. Annotation note 2 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol "#" and a 3 or 4 character label. When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate, on secondary modifications that do not change the nature of the primary modification, or on a combination of a primary and one or more secondary modifications on the same residue, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the special tag "#var". Annotation note 3 - When an entry in the UniMod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the UniMod cross-reference followed by a hash symbol and an amino acid code, "N-term" or "C-term". Annotation note 4 - The elemental formulas are in strict alphabetical order, not in CAS ("C" and "H" first) order. Isotope numbers are in parentheses before the element symbol, and an element should not occur in a formula both with and without an isotope number. In difference formulas, counts can be zero or negative. Annotation note 5 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for other elements without isotope indicators in the formulas. Annotation note 6 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked. Annotation note 7 - The synonym cross-reference "MOD:old name" has been replaced by "MOD:alternate name". Annotation note 8 - The DeltaMass listings for free amino acids have been removed. Most UniMod entries that have not been "approved" have by general agreement not been incorporated unless there has been a request for a specific term by a PRIDE submitter. Annotation note 9 - The Open Mass Spectrometry Search Algorithm, OMSSA, enumerated list of modifications are being incorporated. The string values are synonyms with the synonymtypedef "OMSSA-label", and their integer values (which are supposed to be stable) are definition cross-references.

MOD:00000 protein modification Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue. 18688235 PubMed PSI-MOD-slim ModRes PSI-MOD-label PSI-MOD 1 MOD:00001 alkylated residue A protein modification that effectively replaces a hydrogen atom with an alkyl group. 18688235 PubMed PSI-MOD-slim AlkylRes PSI-MOD-label Source none MOD:01156 PSI-MOD MOD:00002 O-glycosyl-L-serine A protein modification that effectively converts an L-serine residue to O3-glycosylserine. 18688235 PubMed PSI-MOD-slim OGlycoSer PSI-MOD-label Origin S Source natural TermSpec none MOD:00396 MOD:00916 PSI-MOD MOD:00003 UniMod Entry from UniMod. 18688235 PubMed This term is for organizational use only and should not be assigned. [JSG] Source none MOD:00032 PSI-MOD MOD:00004 artifact Artifact entry from UniMod - OBSOLETE because organizational use is no longer required. 18688235 PubMed 1 PSI-MOD MOD:00005 O-glycosyl-L-threonine A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine. 18688235 PubMed PSI-MOD-slim OGlycoThr PSI-MOD-label Origin T Source natural TermSpec none MOD:00396 MOD:00917 PSI-MOD MOD:00006 N-glycosylated residue A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim NGlycoRes PSI-MOD-label Source none MOD:00693 PSI-MOD MOD:00007 selenium substitution for sulfur A protein modification that effectively substitutes a selenium atom for a sulfur atom. 12148805 PubMed 162 UniMod Delta:S(-1)Se(1) PSI-MS-label Se(S)Res PSI-MOD-label Selenium replaces sulphur UniMod-description DiffAvg 46.91 DiffFormula C 0 H 0 N 0 O 0 S -1 Se 1 DiffMono 47.944450 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00745 PSI-MOD MOD:00008 common Entry from UniMod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required. 18688235 PubMed 1 PSI-MOD MOD:00009 natural residue A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue. 6692818 PubMed AA0000 RESID PSI-MOD-slim alpha-amino acid RESID-name Res PSI-MOD-label Origin X Source natural MOD:01157 PSI-MOD MOD:00010 L-alanine residue A protein modification that effectively converts a source amino acid residue to an L-alanine. 29948 ChEBI 0 DeltaMass 6692818 PubMed AA0001 RESID PSI-MOD-slim (2S)-2-aminopropanoic acid RESID-systematic 2-aminopropionic acid RESID-alternate 2-azanylpropanoic acid RESID-alternate Ala PSI-MOD-label alpha-alanine RESID-alternate alpha-aminopropionic acid RESID-alternate L-alanine RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin A Source natural TermSpec none MOD:00570 MOD:00859 MOD:01441 PSI-MOD MOD:00011 L-arginine residue A protein modification that effectively converts a source amino acid residue to an L-arginine. 29952 ChEBI 0 DeltaMass 518876 PubMed 6692818 PubMed AA0002 RESID PSI-MOD-slim (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid RESID-systematic 2-amino-5-(carbamimidamido)pentanoic acid [tautomer] RESID-alternate 2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer] RESID-alternate 2-amino-5-guanidinopentanoic acid RESID-alternate 2-amino-5-guanidinovaleric acid RESID-alternate 2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid RESID-alternate alpha-amino-delta-guanidinovaleric acid RESID-alternate Arg PSI-MOD-label L-arginine RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 12 N 4 O 1 MassAvg 156.19 MassMono 156.101111 Origin R Source natural TermSpec none MOD:01441 PSI-MOD MOD:00012 L-asparagine residue A protein modification that effectively converts a source amino acid residue to an L-asparagine. 29956 ChEBI 0 DeltaMass 15736973 PubMed 5681232 PubMed 6692818 PubMed 9789001 PubMed AA0003 RESID PSI-MOD-slim (2S)-2-amino-4-butanediamic acid RESID-systematic 2,4-bis(azanyl)-4-oxobutanoic acid RESID-alternate 2,4-diamino-4-oxobutanoic acid RESID-alternate 2-amino-3-carbamoylpropanoic acid RESID-alternate 2-amino-4-butanediamic acid RESID-alternate 2-aminosuccinamic acid RESID-alternate 2-aminosuccinic acid 4-amide RESID-alternate alpha-amino-beta-carbamylpropionic acid RESID-alternate alpha-aminosuccinamic acid RESID-alternate Asn PSI-MOD-label aspartic acid 4-amide RESID-alternate aspartic acid beta-amide RESID-alternate beta-asparagine RESID-alternate L-asparagine RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 6 N 2 O 2 MassAvg 114.10 MassMono 114.042927 Origin N Source natural TermSpec none MOD:00859 MOD:01441 PSI-MOD MOD:00013 L-aspartic acid residue A protein modification that effectively converts a source amino acid residue to an L-aspartic acid. 29958 ChEBI 0 DeltaMass 1097438 PubMed 339692 PubMed 4399050 PubMed 5764436 PubMed 6692818 PubMed 8089117 PubMed 9521123 PubMed 9582379 PubMed AA0004 RESID PSI-MOD-slim (2S)-2-aminobutanedioic acid RESID-systematic 2-azanylbutanedioic acid RESID-alternate aminosuccinic acid RESID-alternate Asp PSI-MOD-label L-aspartic acid RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin D Source natural TermSpec none MOD:00859 MOD:01441 PSI-MOD MOD:00014 L-cysteine residue A protein modification that effectively converts a source amino acid residue to an L-cysteine. 29950 ChEBI 0 DeltaMass 1310545 PubMed 15790858 PubMed 3447159 PubMed 6692818 PubMed 7338899 PubMed AA0005 RESID From DeltaMass: Average Mass: 121. PSI-MOD-slim (2R)-2-amino-3-sulfanylpropanoic acid RESID-systematic (R)-cysteine RESID-alternate 2-amino-3-mercaptopropanoic acid RESID-alternate 2-amino-3-mercaptopropionic acid RESID-alternate 2-azanyl-3-sulfanylpropanoic acid RESID-alternate 3-mercapto-L-alanine RESID-alternate alpha-amino-beta-mercaptopropanoic acid RESID-alternate alpha-amino-beta-mercaptopropionic acid RESID-alternate alpha-amino-beta-thiolpropionic acid RESID-alternate beta-mercaptoalanine RESID-alternate Cys PSI-MOD-label Cysteine (C, Cys) DeltaMass-label half-cystine RESID-alternate L-(+)-cysteine RESID-alternate L-cysteine RESID-name thioserine RESID-alternate DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 S 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 1 S 1 MassAvg 103.14 MassMono 103.009185 Origin C Source natural TermSpec none MOD:00859 MOD:01441 PSI-MOD MOD:00015 L-glutamic acid residue A protein modification that effectively converts a source amino acid residue to an L-glutamic acid. 29972 ChEBI 0 DeltaMass 1881881 PubMed 4565668 PubMed 4922541 PubMed 6692818 PubMed 9326660 PubMed 957425 PubMed AA0006 RESID PSI-MOD-slim (2S)-2-aminopentanedioic acid RESID-systematic 1-aminopropane-1,3-dicarboxylic acid RESID-alternate 2-aminoglutaric acid RESID-alternate 2-azanylpentanedioic acid RESID-alternate alpha-aminoglutaric acid RESID-alternate Glu PSI-MOD-label glutaminic acid RESID-alternate L-glutamic acid RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin E Source natural TermSpec none MOD:00859 MOD:01441 PSI-MOD MOD:00016 L-glutamine residue A protein modification that effectively converts a source amino acid residue to an L-glutamine. 30011 ChEBI 0 DeltaMass 3340166 PubMed 6692818 PubMed 9342308 PubMed AA0007 RESID PSI-MOD-slim (2S)-2-amino-5-pentanediamic acid RESID-systematic 2,5-bis(azanyl)-5-oxopentanoic acid RESID-alternate 2,5-diamino-5-oxopentanoic acid RESID-alternate 2-amino-4-carbamoylbutanoic acid RESID-alternate 2-aminoglutaramic acid RESID-alternate alpha-amino-gamma-carbamylbutyric acid RESID-alternate Gln PSI-MOD-label glutamic acid 5-amide RESID-alternate glutamic acid gamma-amide RESID-alternate glutamide RESID-alternate L-glutamine RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 8 N 2 O 2 MassAvg 128.13 MassMono 128.058578 Origin Q Source natural TermSpec none MOD:00894 MOD:01441 PSI-MOD MOD:00017 glycine residue A protein modification that effectively converts a source amino acid residue to a glycine. 29947 ChEBI 0 DeltaMass 1310545 PubMed 6692818 PubMed AA0008 RESID PSI-MOD-slim aminoacetic acid RESID-alternate aminoethanoic acid RESID-systematic azanylethanoic acid RESID-alternate Gly PSI-MOD-label glycine RESID-name glycocoll RESID-alternate DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 2 H 3 N 1 O 1 MassAvg 57.05 MassMono 57.021464 Origin G Source natural TermSpec none MOD:01441 PSI-MOD MOD:00018 L-histidine residue A protein modification that effectively converts a source amino acid residue to an L-histidine. 29979 ChEBI 0 DeltaMass 14342316 PubMed 2722967 PubMed 512 PubMed 5460889 PubMed 6129252 PubMed 6692818 PubMed 6876174 PubMed AA0009 RESID PSI-MOD-slim (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid RESID-systematic (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer] RESID-alternate 2-azanyl-3-(1H-imidazol-4-yl)propanoic acid RESID-alternate 2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer] RESID-alternate 4-(2-amino-2-carboxyethyl)imidazole RESID-alternate alpha-amino-beta-(4-imidazole)propionic acid RESID-alternate glyoxaline-5-alanine RESID-alternate His PSI-MOD-label L-histidine RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 7 N 3 O 1 MassAvg 137.14 MassMono 137.058912 Origin H Source natural TermSpec none MOD:01441 PSI-MOD MOD:00019 L-isoleucine residue A protein modification that effectively converts a source amino acid residue to an L-isoleucine. 30009 ChEBI 0 DeltaMass 6692818 PubMed AA0010 RESID PSI-MOD-slim (2S,3S)-2-amino-3-methylpentanoic acid RESID-systematic 2-azanyl-3-methylpentanoic acid RESID-alternate 3-methyl-norvaline RESID-alternate alpha-amino-beta-methylvaleric acid RESID-alternate Ile PSI-MOD-label Isoleucyl DeltaMass-label L-erythro-isoleucine RESID-alternate L-isoleucine RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin I Source natural TermSpec none MOD:00306 MOD:01441 PSI-MOD MOD:00020 L-leucine residue A protein modification that effectively converts a source amino acid residue to an L-leucine. 30006 ChEBI 0 DeltaMass 11478885 PubMed 6692818 PubMed AA0011 RESID PSI-MOD-slim (2S)-2-amino-4-methylpentanoic acid RESID-systematic 2-azanyl-4-methylpentanoic acid RESID-alternate 4-methyl-norvaline RESID-alternate alpha-amino-gamma-methylvaleric acid RESID-alternate alpha-aminoisocaproic acid RESID-alternate L-leucine RESID-name Leu PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin L Source natural TermSpec none MOD:00306 MOD:01441 PSI-MOD MOD:00021 L-lysine residue A protein modification that effectively converts a source amino acid residue to L-lysine. 29967 ChEBI 0 DeltaMass 3106962 PubMed 6120171 PubMed 6692818 PubMed AA0012 RESID PSI-MOD-slim (2S)-2,6-diaminohexanoic acid RESID-systematic 2,6-bis(azanyl)hexanoic acid RESID-alternate 6-amino-L-norleucine RESID-alternate ACT_SITE Schiff-base intermediate with substrate UniProt-feature alpha,epsilon-diaminocaproic acid RESID-alternate L-lysine RESID-name Lys PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 12 N 2 O 1 MassAvg 128.18 MassMono 128.094963 Origin K Source natural TermSpec none MOD:00893 MOD:01441 PSI-MOD MOD:00022 L-methionine residue A protein modification that effectively converts a source amino acid residue to L-methionine. 29983 ChEBI 0 DeltaMass 6411710 PubMed 6692818 PubMed AA0013 RESID From DeltaMass: Average Mass: 149 PSI-MOD-slim (2S)-2-amino-4-(methylsulfanyl)butanoic acid RESID-systematic 2-amino-4-(methylthio)butanoic acid RESID-alternate 2-amino-4-(methylthio)butyric acid RESID-alternate 2-azanyl-4-(methylsulfanyl)butanoic acid RESID-alternate alpha-amino-gamma-methylmercaptobutyric acid RESID-alternate alpha-amino-gamma-methylthiobutyric acid RESID-alternate gamma-methylthio-alpha-aminobutyric acid RESID-alternate L-(-)-methionine RESID-alternate L-methionine RESID-name Met PSI-MOD-label S-methyl-L-homocysteine RESID-alternate DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 S 0 DiffMono 0.000000 Formula C 5 H 9 N 1 O 1 S 1 MassAvg 131.19 MassMono 131.040485 Origin M Source natural TermSpec none MOD:01441 PSI-MOD MOD:00023 L-phenylalanine residue A protein modification that effectively converts a source amino acid residue to L-phenylalanine. 29997 ChEBI 0 DeltaMass 6692818 PubMed AA0014 RESID PSI-MOD-slim (2S)-2-amino-3-phenylpropanoic acid RESID-systematic 2-azanyl-3-phenylpropanoic acid RESID-alternate alpha-amino-beta-phenylpropionic acid RESID-alternate L-phenylalanine RESID-name Phe PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 9 H 9 N 1 O 1 MassAvg 147.18 MassMono 147.068414 Origin F Source natural TermSpec none MOD:01441 PSI-MOD MOD:00024 L-proline residue A protein modification that effectively converts a source amino acid residue to L-proline. 30017 ChEBI 0 DeltaMass 6692818 PubMed 8547259 PubMed AA0015 RESID PSI-MOD-slim (2S)-2-pyrrolidinecarboxylic acid RESID-systematic L-proline RESID-name Pro PSI-MOD-label pyrrolidine-2-carboxylic acid RESID-alternate DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 7 N 1 O 1 MassAvg 97.12 MassMono 97.052764 Origin P Source natural TermSpec none MOD:01441 PSI-MOD MOD:00025 L-serine residue A protein modification that effectively converts a source amino acid residue to L-serine. 29999 ChEBI 0 DeltaMass 4399050 PubMed 6692818 PubMed AA0016 RESID PSI-MOD-slim (2S)-2-amino-3-hydroxypropanoic acid RESID-systematic 2-azanyl-3-hydroxypropanoic acid RESID-alternate 3-hydroxy-L-alanine RESID-alternate alpha-amino-beta-hydroxypropionic acid RESID-alternate beta-hydroxyalanine RESID-alternate L-serine RESID-name Ser PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 2 MassAvg 87.08 MassMono 87.032028 Origin S Source natural TermSpec none MOD:01441 PSI-MOD MOD:00026 L-threonine residue A protein modification that effectively converts a source amino acid residue to L-threonine. 30013 ChEBI 0 DeltaMass 2989287 PubMed 6692818 PubMed AA0017 RESID PSI-MOD-slim (2S,3R)-2-amino-3-hydroxybutanoic acid RESID-systematic 2-azanyl-3-hydroxybutanoic acid RESID-alternate alpha-amino-beta-hydroxybutyric acid RESID-alternate beta-methylserine RESID-alternate L-threo-threonine RESID-alternate L-threonine RESID-name Thr PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 7 N 1 O 2 MassAvg 101.10 MassMono 101.047678 Origin T Source natural TermSpec none MOD:01441 PSI-MOD MOD:00027 L-tryptophan residue A protein modification that effectively converts a source amino acid residue to L-tryptophan. 29954 ChEBI 0 DeltaMass 2059637 PubMed 6692818 PubMed 9324768 PubMed AA0018 RESID PSI-MOD-slim (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid RESID-systematic 2-azanyl-3-(1H-indol-3-yl)propanoic acid RESID-alternate alpha-amino-beta-(3-indolyl)propionoic acid RESID-alternate beta(3-indolyl)alanine RESID-alternate L-tryptophan RESID-name Trp PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 11 H 10 N 2 O 1 MassAvg 186.21 MassMono 186.079313 Origin W Source natural TermSpec none MOD:01441 PSI-MOD MOD:00028 L-tyrosine residue A protein modification that effectively converts a source amino acid residue to L-tyrosine. 29975 ChEBI 0 DeltaMass 2190093 PubMed 2542938 PubMed 5550972 PubMed 6061414 PubMed 6120171 PubMed 6692818 PubMed AA0019 RESID PSI-MOD-slim (2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid RESID-systematic 2-azanyl-3-(4-hydoxyphenyl)propanoic acid RESID-alternate alpha-amino-beta-(para-hydroxyphenyl)propionic acid RESID-alternate L-tyrosine RESID-name p-tyrosine RESID-alternate para-hydroxyphenylalanine RESID-alternate Tyr PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 9 H 9 N 1 O 2 MassAvg 163.18 MassMono 163.063329 Origin Y Source natural TermSpec none MOD:01441 PSI-MOD MOD:00029 L-valine residue A protein modification that effectively converts a source amino acid residue to an L-valine. 30015 ChEBI 0 DeltaMass 6692818 PubMed AA0020 RESID PSI-MOD-slim (2S)-2-amino-3-methylbutanoic acid RESID-systematic 2-azanyl-3-methylbutanoic acid RESID-alternate alpha-amino-beta-methylbutyric acid RESID-alternate alpha-aminoisovaleric acid RESID-alternate L-valine RESID-name Val PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 9 N 1 O 1 MassAvg 99.13 MassMono 99.068414 Origin V Source natural TermSpec none MOD:01441 PSI-MOD MOD:00030 N-formyl-L-methionine residue A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification. 33718 ChEBI 10825024 PubMed 11152118 PubMed 2165784 PubMed 3042771 PubMed 8758896 PubMed AA0021#FMET RESID 107#N-term UniMod PSI-MOD-slim (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid RESID-systematic 2-formamido-4-(methylsulfanyl)butanoic acid RESID-alternate 2-formylamino-4-(methylthio)butanoic acid RESID-alternate 2-formylazanyl-4-(methylsulfanyl)butanoic acid RESID-alternate Addition of N-formyl met UniMod-description fMet PSI-MOD-label FormylMet PSI-MS-label MOD_RES N-formylmethionine UniProt-feature N-formyl-L-methionine RESID-name N-formylated L-methionine PSI-MOD-alternate nformylmet OMSSA-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 S 0 DiffMono 0.000000 Formula C 6 H 10 N 1 O 2 S 1 MassAvg 160.21 MassMono 160.043225 Origin M Source natural TermSpec N-term MOD:00409 MOD:00868 MOD:01696 PSI-MOD MOD:00031 L-selenocysteine residue A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification. 30000 ChEBI 10523135 PubMed 1066676 PubMed 2037562 PubMed 2963330 PubMed 4734725 PubMed 6076213 PubMed 6217842 PubMed 6714945 PubMed AA0022 RESID PSI-MOD-slim (2R)-2-amino-3-selanylpropanoic acid RESID-systematic 2-azanyl-3-selanylpropanoic acid RESID-alternate 3-selenylalanine RESID-alternate L-selenocysteine RESID-name NON_STD Selenocysteine UniProt-feature Sec PSI-MOD-label SeCys RESID-alternate selenium cysteine RESID-alternate DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 Se 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 1 Se 1 MassAvg 150.05 MassMono 150.953635 Origin U Source natural TermSpec none MOD:00745 MOD:00859 MOD:00868 PSI-MOD MOD:00032 uncategorized protein modification A protein modification that is not chemically categorized. 18688235 PubMed This term is for organizational use only and should not be assigned. [JSG] Source none MOD:00000 PSI-MOD MOD:00033 crosslinked residues A protein modification that crosslinks two or more amino acid residues with covalent bonds. 18688235 PubMed The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site. PSI-MOD-slim XLNK-Res-Res PSI-MOD-label Source none MOD:01156 PSI-MOD MOD:00034 L-cystine (cross-link) A protein modification that effectively cross-links two L-cysteine residues to form L-cystine. 16283 ChEBI 0 DeltaMass 1988019 PubMed 2001356 PubMed 2076469 PubMed 3083866 PubMed 366603 PubMed 7918467 PubMed 8344916 PubMed AA0025#CYS2 RESID Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765. PSI-MOD-slim (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) RESID-systematic 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid RESID-misnomer 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) RESID-alternate 3,3'-dithiobis(2-aminopropanoic acid) RESID-alternate 3,3'-dithiobisalanine RESID-alternate 3,3'-dithiodialanine RESID-alternate beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide RESID-alternate beta,beta'-dithiodialanine RESID-alternate bis(alpha-aminopropionic acid)-beta-disulfide RESID-alternate bis(beta-amino-beta-carboxyethyl)disulfide RESID-alternate Cys2 PSI-MOD-label Cystine ((Cys)2) DeltaMass-label dicysteine RESID-alternate DISULFID UniProt-feature DISULFID Interchain UniProt-feature L-cystine RESID-name XLNK-SCys-SCys PSI-MOD-label DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 2 S 2 MassAvg 204.26 MassMono 204.002720 Origin C, C Source natural TermSpec none MOD:00689 PSI-MOD MOD:00035 (2S,3R)-3-hydroxyasparagine A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine. 11823643 PubMed 2820791 PubMed AA0026 RESID PSI-MOD-slim (2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid RESID-alternate (2S,3R)-2-amino-3-hydroxy-4-butanediamic acid RESID-systematic (2S,3R)-3-hydroxyasparagine RESID-name (3R)3HyAsn PSI-MOD-label 2-azanyl-3-hydroxy-4-butanediamic acid RESID-alternate erythro-beta-hydroxylated L-asparagine PSI-MOD-alternate L-erythro-beta-hydroxyasparagine RESID-alternate MOD_RES (3R)-3-hydroxyasparagine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 4 H 6 N 2 O 3 MassAvg 130.10 MassMono 130.037842 Origin N Source natural TermSpec none MOD:01688 PSI-MOD MOD:00036 (2S,3R)-3-hydroxyaspartic acid A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid. 6572939 PubMed 6871167 PubMed 8355279 PubMed AA0027 RESID 35#D UniMod PSI-MOD-slim (2S,3R)-2-amino-3-hydroxybutanedioic acid RESID-systematic (2S,3R)-3-hydroxyaspartic acid RESID-name (3R)3HyAsp PSI-MOD-label 2-amino-3-hydroxysuccinic acid RESID-alternate 2-azanyl-3-hydroxybutanedioic acid RESID-alternate 3-hydroxyaspartic acid RESID-alternate erythro-beta-hydroxylated L-aspartic acid PSI-MOD-alternate hydroxylationd OMSSA-label L-erythro-beta-hydroxyaspartic acid RESID-alternate MOD_RES (3R)-3-hydroxyaspartate UniProt-feature Oxidation PSI-MS-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 4 H 5 N 1 O 4 MassAvg 131.09 MassMono 131.021858 Origin D Source natural TermSpec none MOD:01926 PSI-MOD MOD:00037 5-hydroxy-L-lysine A protein modification that effectively converts an L-lysine residue to one of the diastereomeric 5-hydroxy-L-lysine residues. 60175 ChEBI 18688235 PubMed PSI-MOD-slim 5-hydroxylated L-lysine PSI-MOD-alternate 5HyLys PSI-MOD-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 12 N 2 O 2 MassAvg 144.17 MassMono 144.089878 Origin K Source natural TermSpec none MOD:01047 PSI-MOD MOD:00038 3-hydroxy-L-proline A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline. 16889 ChEBI 2400108 PubMed 3734192 PubMed 4343807 PubMed AA0029 RESID PSI-MOD-slim (2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid RESID-systematic 3-hydroxy-L-proline RESID-name 3-hydroxylated L-proline PSI-MOD-alternate 3-trans-hydroxy-L-proline RESID-alternate 3HyPro PSI-MOD-label beta-hydroxypyrrolidine-alpha-carboxylic acid RESID-alternate L-threo-3-hydroxyproline RESID-alternate MOD_RES 3-hydroxyproline UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 7 N 1 O 2 MassAvg 113.12 MassMono 113.047678 Origin P Source natural TermSpec none MOD:01024 PSI-MOD MOD:00039 4-hydroxy-L-proline A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline 18095 ChEBI 11292863 PubMed 2400108 PubMed 3734192 PubMed AA0030 RESID PSI-MOD-slim (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid RESID-systematic 4-hydroxy-L-proline RESID-name 4-hydroxylated L-proline PSI-MOD-alternate 4-hydroxyproline RESID-alternate 4-trans-hydroxy-L-proline RESID-alternate 4HyPro PSI-MOD-label gamma-hydroxypyrrolidine-alpha-carboxylic acid RESID-alternate L-threo-4-hydroxyproline RESID-alternate MOD_RES 4-hydroxyproline UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 7 N 1 O 2 MassAvg 113.12 MassMono 113.047678 Origin P Source natural TermSpec none MOD:01024 PSI-MOD MOD:00040 2-pyrrolidone-5-carboxylic acid (Gln) A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid. 30652 ChEBI 123 DeltaMass 10214721 PubMed 1836357 PubMed 26343 PubMed 3473473 PubMed AA0031#GLN RESID 28#Q UniMod DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1 PSI-MOD-slim (2S)-5-oxo-2-pyrrolidinecarboxylic acid RESID-systematic 2-oxopyrrolidine-5-carboxylic acid RESID-alternate 2-pyrrolidone-5-carboxylic acid RESID-name 5-oxoproline RESID-alternate 5-oxopyrrolidine-2-carboxylic acid RESID-alternate 5-pyrrolidone-2-carboxylic acid RESID-alternate Gln->pyro-Glu PSI-MS-label MOD_RES Pyrrolidone carboxylic acid UniProt-feature N-pyrrolidone carboxyl (N terminus) DeltaMass-label ntermpeppyroq OMSSA-label PCA RESID-alternate PyrGlu(Gln) PSI-MOD-label Pyro-glu from Q UniMod-description pyroglutamic acid RESID-alternate Pyroglutamic Acid formed from Gln DeltaMass-label Pyroglutamyl DeltaMass-label DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 5 H 6 N 1 O 2 MassAvg 112.11 MassMono 112.039853 Origin Q Source natural TermSpec N-term MOD:00907 MOD:01048 MOD:01160 PSI-MOD MOD:00041 L-gamma-carboxyglutamic acid A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid. 217 DeltaMass 10517147 PubMed 1807167 PubMed 3263814 PubMed 4528109 PubMed 7457858 PubMed 8135347 PubMed 8868490 PubMed 9188685 PubMed AA0032 RESID 299#E UniMod DeltaMass has an incorrect formula C 6 H 7 N 5 O 1 (N and O reversed) with mass 173. PSI-MOD-slim (3S)-3-aminopropane-1,1,3-tricarboxylic acid RESID-systematic (3S)-3-azanylpropane-1,1,3-tricarboxylic acid RESID-alternate 1-carboxyglutamic acid RESID-misnomer 3-amino-1,1,3-propanetricarboxylic acid RESID-alternate 3-azanylpropane-1,1,3-tricarboxylic acid RESID-alternate 4-carboxyglutamic acid RESID-alternate 4CbxGlu PSI-MOD-label Carboxy PSI-MS-label Carboxy UniMod-interim Carboxy Glutamyl DeltaMass-label Carboxylation UniMod-description gamma-carboxylated L-glutamic acid PSI-MOD-alternate gammacarboxyle OMSSA-label L-gamma-carboxyglutamic acid RESID-name MOD_RES 4-carboxyglutamate UniProt-feature DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 DiffMono 43.989829 Formula C 6 H 7 N 1 O 5 MassAvg 173.12 MassMono 173.032422 Origin E Source natural TermSpec none MOD:00906 MOD:01152 PSI-MOD MOD:00042 L-aspartic 4-phosphoric anhydride A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride. 15836 ChEBI 4357737 PubMed AA0033 RESID 21#D UniMod (2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid RESID-systematic 2-aminobutanedioic 4-phosphoric anhydride RESID-alternate 2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid RESID-alternate 4-oxo-O-phosphono-L-homoserine RESID-alternate 4-phosphoaspartic acid RESID-alternate 4-phosphorylated L-aspartatic acid PSI-MOD-alternate ACT_SITE 4-aspartylphosphate intermediate UniProt-feature beta-aspartyl phosphate RESID-alternate L-aspartic 4-phosphoric anhydride RESID-name MOD_RES 4-aspartylphosphate UniProt-feature PAsp PSI-MOD-label Phospho PSI-MS-label Phosphorylation UniMod-description DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 4 H 6 N 1 O 6 P 1 MassAvg 195.07 MassMono 194.993274 Origin D Source natural TermSpec none MOD:00904 MOD:01455 PSI-MOD MOD:00043 S-phospho-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine. 3142516 PubMed 7961745 PubMed 8128219 PubMed AA0034 RESID 21#C UniMod (2R)-2-amino-3-(phosphonosulfanyl)propanoic acid RESID-systematic 2-azanyl-3-(phosphonosulfanyl)propanoic acid RESID-alternate ACT_SITE Phosphocysteine intermediate UniProt-feature cysteine phosphate thioester RESID-alternate MOD_RES Phosphocysteine UniProt-feature PCys PSI-MOD-label Phospho PSI-MS-label Phosphorylation UniMod-description S-phospho-L-cysteine RESID-name S-phosphonocysteine RESID-alternate S-phosphorylated L-cysteine PSI-MOD-alternate S3-phosphocysteine RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 S 0 DiffMono 79.966331 Formula C 3 H 6 N 1 O 4 P 1 S 1 MassAvg 183.12 MassMono 182.975515 Origin C Source natural TermSpec none MOD:00696 MOD:00777 MOD:00905 PSI-MOD MOD:00044 1'-phospho-L-histidine A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine). 11038361 PubMed 5642389 PubMed 6692818 PubMed AA0035 RESID PSI-MOD-slim (2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid RESID-systematic 1'-phospho-L-histidine RESID-name 2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid RESID-alternate ACT_SITE Tele-phosphohistidine intermediate UniProt-feature histidine-3-phosphate RESID-misnomer histidine-N(epsilon)-phosphate RESID-alternate histidine-N1'-phosphate RESID-alternate MOD_RES Tele-phosphohistidine UniProt-feature N(tau)-phosphohistidine RESID-alternate N1-phosphonohistidine RESID-alternate NE2-phosphonohistidine RESID-alternate Ntau-phosphorylated L-histidine PSI-MOD-alternate NtPHis PSI-MOD-label Phospho PSI-MS-label Phosphorylation UniMod-description tele-phosphohistidine RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 6 H 8 N 3 O 4 P 1 MassAvg 217.12 MassMono 217.025242 Origin H Source natural TermSpec none MOD:00890 PSI-MOD MOD:00045 3'-phospho-L-histidine A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine). 1549615 PubMed 5642389 PubMed 6692818 PubMed 7669763 PubMed 7803390 PubMed AA0036 RESID PSI-MOD-slim (2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid RESID-systematic 2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid RESID-alternate 3'-phospho-L-histidine RESID-name ACT_SITE Pros-phosphohistidine intermediate UniProt-feature histidine-1-phosphate RESID-misnomer histidine-N(delta)-phosphate RESID-alternate histidine-N3'-phosphate RESID-alternate MOD_RES Pros-phosphohistidine UniProt-feature N(pi)-phosphohistidine RESID-alternate N3-phosphonohistidine RESID-alternate ND1-phosphonohistidine RESID-alternate Npi-phosphorylated L-histidine PSI-MOD-alternate NpPHis PSI-MOD-label Phospho PSI-MS-label Phosphorylation UniMod-description pros-phosphohistidine RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 6 H 8 N 3 O 4 P 1 MassAvg 217.12 MassMono 217.025242 Origin H Source natural TermSpec none MOD:00890 PSI-MOD MOD:00046 O-phospho-L-serine A protein modification that effectively converts an L-serine residue to O-phospho-L-serine. 15811 ChEBI 0 DeltaMass 12923550 PubMed 4065410 PubMed 8061611 PubMed AA0037 RESID 21#S UniMod PSI-MOD-slim (2S)-2-amino-3-(phosphonooxy)propanoic acid RESID-systematic 2-amino-3-hydroxypropanoic acid 3-phosphate RESID-alternate 2-azanyl-3-(phosphonooxy)propanoic acid RESID-alternate ACT_SITE Phosphoserine intermediate UniProt-feature MOD_RES Phosphoserine UniProt-feature O-phospho-L-serine RESID-name O-phosphonoserine RESID-alternate O-phosphorylated L-serine PSI-MOD-alternate O3-phosphoserine RESID-alternate OPSer PSI-MOD-label Phospho PSI-MS-label Phospho Seryl DeltaMass-label Phosphorylation UniMod-description phosphorylations OMSSA-label serine phosphate ester RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 3 H 6 N 1 O 5 P 1 MassAvg 167.06 MassMono 166.998359 Origin S Source natural TermSpec none MOD:00771 MOD:00916 MOD:01455 PSI-MOD MOD:00047 O-phospho-L-threonine A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine. 21967 ChEBI 0 DeltaMass 12923550 PubMed 7678926 PubMed AA0038 RESID 21#T UniMod PSI-MOD-slim (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid RESID-systematic 2-amino-3-hydroxybutanoic acid 3-phosphate RESID-alternate 2-azanyl-3-(phosphonooxy)butanoic acid RESID-alternate MOD_RES Phosphothreonine UniProt-feature O-phospho-L-threonine RESID-name O-phosphorylated L-threonine PSI-MOD-alternate O3-phosphothreonine RESID-alternate OPThr PSI-MOD-label Phospho PSI-MS-label Phospho Threonyl DeltaMass-label Phosphorylation UniMod-description phosphorylationt OMSSA-label threonine phosphate ester RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 4 H 8 N 1 O 5 P 1 MassAvg 181.08 MassMono 181.014009 Origin T Source natural TermSpec none MOD:00773 MOD:00917 MOD:01455 PSI-MOD MOD:00048 O4'-phospho-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine. 0 DeltaMass 10226369 PubMed 1725475 PubMed AA0039 RESID 21#Y UniMod PSI-MOD-slim (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid RESID-systematic 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate RESID-alternate 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid RESID-alternate MOD_RES Phosphotyrosine UniProt-feature O4'-phospho-L-tyrosine RESID-name O4'-phosphorylated L-tyrosine PSI-MOD-alternate O4-phosphotyrosine RESID-alternate OPTyr PSI-MOD-label Phospho PSI-MS-label Phospho Tyrosinyl DeltaMass-label Phosphorylation UniMod-description phosphorylationy OMSSA-label tyrosine phosphate RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 9 H 10 N 1 O 5 P 1 MassAvg 243.15 MassMono 243.029659 Origin Y Source natural TermSpec none MOD:00774 MOD:00919 MOD:01455 PSI-MOD MOD:00049 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine A protein modification that effectively converts an L-histidine residue to diphthamide. 16692 ChEBI 122 DeltaMass 15316019 PubMed 7430147 PubMed AA0040 RESID 375#H UniMod (2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium RESID-systematic (3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium RESID-alternate 1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium RESID-alternate 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine RESID-name 2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole RESID-alternate 2-[3-carboxamido-3-(trimethylammonio)propyl]histidine RESID-alternate 2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid RESID-alternate 2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide RESID-alternate alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium RESID-alternate Diphth PSI-MOD-label Diphthamide PSI-MS-label Diphthamide UniMod-description diphthamide RESID-alternate diphthamide (from histidine) DeltaMass-label MOD_RES Diphthamide UniProt-feature DiffAvg 143.21 DiffFormula C 7 H 15 N 2 O 1 DiffMono 143.117890 FormalCharge 1+ Formula C 13 H 22 N 5 O 2 MassAvg 280.35 MassMono 280.176801 Origin H Source natural TermSpec none MOD:00909 PSI-MOD MOD:00050 N-acetyl-L-alanine A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine. 363452 PubMed 4700463 PubMed AA0041 RESID PSI-MOD-slim (2S)-2-(acetamido)propanoic acid RESID-systematic 2-(acetylamino)propanoic acid RESID-alternate 2-(acetylazanyl)propanoic acid RESID-alternate AcAla PSI-MOD-label acetylalanine RESID-alternate MOD_RES N-acetylalanine UniProt-feature N-acetyl-L-alanine RESID-name N-acetylated L-alanine PSI-MOD-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 5 H 8 N 1 O 2 MassAvg 114.12 MassMono 114.055504 Origin A Source natural TermSpec N-term MOD:00901 MOD:01458 PSI-MOD MOD:00051 N-acetyl-L-aspartic acid A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid. 21547 ChEBI 1560020 PubMed 2395459 PubMed AA0042 RESID PSI-MOD-slim (2S)-2-(acetamido)butanedioic acid RESID-systematic 2-(acetylamino)butanedioic acid RESID-alternate 2-(acetylazanyl)butanedioic acid RESID-alternate AcAsp PSI-MOD-label acetylaspartic acid RESID-alternate MOD_RES N-acetylaspartate UniProt-feature N-acetyl-L-aspartic acid RESID-name N-acetylated L-aspartic acid PSI-MOD-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 6 H 8 N 1 O 4 MassAvg 158.13 MassMono 158.045333 Origin D Source natural TermSpec N-term MOD:00904 MOD:01458 PSI-MOD MOD:00052 N-acetyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine. 28939 ChEBI 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 1500421 PubMed 15350136 PubMed 6725286 PubMed AA0043 RESID incidental to RESID:AA0223 PSI-MOD-slim (2R)-2-acetamido-3-sulfanylpropanoic acid RESID-systematic 2-acetylamino-3-mercaptopropanoic acid RESID-alternate 2-acetylamino-3-sulfanylpropanoic acid RESID-alternate 2-acetylazanyl-3-sulfanylpropanoic acid RESID-alternate Acetyl PSI-MS-label MOD_RES N-acetylcysteine UniProt-feature N-acetyl-L-cysteine RESID-name N-acetylated cysteine PSI-MOD-alternate N-acetylcysteine RESID-alternate NAcCys PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 S 0 DiffMono 42.010565 Formula C 5 H 8 N 1 O 2 S 1 MassAvg 146.18 MassMono 146.027574 Origin C Source natural TermSpec N-term MOD:00646 MOD:01458 PSI-MOD MOD:00053 N-acetyl-L-glutamic acid A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid. 17533 ChEBI 6725286 PubMed AA0044 RESID PSI-MOD-slim (2S)-2-(acetamido)pentanedioic acid RESID-systematic 2-(acetylamino)pentanedioic acid RESID-alternate 2-(acetylazanyl)pentanedioic acid RESID-alternate acetylglutamic acid RESID-alternate AcGlu PSI-MOD-label MOD_RES N-acetylglutamate UniProt-feature N-acetyl-L-glutamic acid RESID-name N-acetylated L-glutamic acid PSI-MOD-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 7 H 10 N 1 O 4 MassAvg 172.16 MassMono 172.060983 Origin E Source natural TermSpec N-term MOD:00906 MOD:01458 PSI-MOD MOD:00054 N-acetyl-L-glutamine A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine. AA0045 RESID This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. (2S)-2-acetamido-5-pentanediamic acid RESID-systematic 2-acetylamino-5-amino-5-oxopentanoic acid RESID-alternate 2-acetylamino-5-pentanediamic acid RESID-alternate 2-acetylazanyl-5-azanyl-5-oxopentanoic acid RESID-alternate acetylglutamine RESID-alternate AcGln PSI-MOD-label N-acetyl-L-glutamine RESID-name N-acetylated L-glutamine PSI-MOD-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 7 H 11 N 2 O 3 MassAvg 171.18 MassMono 171.076967 Origin Q Source artifact TermSpec N-term MOD:00907 MOD:01458 PSI-MOD MOD:00055 N-acetylglycine A protein modification that effectively converts a glycine residue to N-acetylglycine. 272676 PubMed 5545094 PubMed 6754709 PubMed AA0046 RESID PSI-MOD-slim (acetylamino)acetic acid RESID-alternate (acetylazanyl)ethanoic acid RESID-alternate 2-(acetamido)ethanoic acid RESID-systematic 2-(acetylamino)ethanoic acid RESID-alternate aceturic acid RESID-alternate AcGly PSI-MOD-label MOD_RES N-acetylglycine UniProt-feature N-acetylated glycine PSI-MOD-alternate N-acetylglycine RESID-name DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 4 H 6 N 1 O 2 MassAvg 100.10 MassMono 100.039853 Origin G Source natural TermSpec N-term MOD:00908 MOD:01458 PSI-MOD MOD:00056 N-acetyl-L-isoleucine A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine. 8034631 PubMed AA0047 RESID This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. (2S,3S)-2-acetamido-3-methylpentanoic acid RESID-systematic 2-acetylamino-3-methylpentanoic acid RESID-alternate 2-acetylazanyl-3-methylpentanoic acid RESID-alternate acetylisoleucine RESID-alternate AcIle PSI-MOD-label N-acetyl-L-isoleucine RESID-name N-acetylated L-isoleucine PSI-MOD-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 14 N 1 O 2 MassAvg 156.20 MassMono 156.102454 Origin I Source artifact TermSpec N-term MOD:00910 MOD:01458 PSI-MOD MOD:00057 N2-acetyl-L-lysine A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed AA0048 RESID This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. (2S)-2-acetamido-6-aminohexanoic acid RESID-systematic 2-acetylamino-6-aminohexanoic acid RESID-alternate 2-acetylazanyl-6-azanylhexanoic acid RESID-alternate Acetyl PSI-MS-label N2-acetyl-L-lysine RESID-name N2-acetylated L-lysine PSI-MOD-alternate N2-acetyllysine RESID-alternate N2AcLys PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 15 N 2 O 2 MassAvg 171.22 MassMono 171.113353 Origin K Source artifact TermSpec N-term MOD:00723 MOD:01458 PSI-MOD MOD:00058 N-acetyl-L-methionine A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine. 7944406 PubMed AA0049 RESID PSI-MOD-slim (2S)-2-acetamido-4-(methylsulfanyl)butanoic acid RESID-systematic 2-acetylamino-4-(methylsulfanyl)butanoic acid RESID-alternate 2-acetylamino-4-(methylthio)butanoic acid RESID-alternate 2-acetylazanyl-4-(methylsulfanyl)butanoic acid RESID-alternate acetylmethionine RESID-alternate AcMet PSI-MOD-label methionamine RESID-alternate MOD_RES N-acetylmethionine UniProt-feature N-acetyl-L-methionine RESID-name N-acetylated L-methionine PSI-MOD-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 S 0 DiffMono 42.010565 Formula C 7 H 12 N 1 O 2 S 1 MassAvg 174.24 MassMono 174.058875 Origin M Source natural TermSpec N-term MOD:00913 MOD:01458 PSI-MOD MOD:00059 N-acetyl-L-proline A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline. 2928307 PubMed AA0050 RESID PSI-MOD-slim (2S)-1-acetyl-2-pyrrolidinecarboxylic acid RESID-systematic 1-acetylproline RESID-alternate acetylproline RESID-alternate MOD_RES N-acetylproline UniProt-feature N-acetyl-L-proline RESID-name N-acetylated L-proline PSI-MOD-alternate N-acetylproline RESID-alternate NAcPro PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 7 H 10 N 1 O 2 MassAvg 140.16 MassMono 140.071154 Origin P Source natural TermSpec N-term MOD:00915 MOD:01458 PSI-MOD MOD:00060 N-acetyl-L-serine A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 1880797 PubMed 2106685 PubMed 6997045 PubMed AA0051 RESID PSI-MOD-slim (2S)-2-acetamido-3-hydroxypropanoic acid RESID-systematic 2-acetylamino-3-hydroxypropanoic acid RESID-alternate 2-acetylazanyl-3-hydroxypropanoic acid RESID-alternate Acetyl PSI-MS-label MOD_RES N-acetylserine UniProt-feature N-acetyl-L-serine RESID-name N-acetylated L-serine PSI-MOD-alternate N-acetylserine RESID-alternate NAcSer PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 5 H 8 N 1 O 3 MassAvg 130.12 MassMono 130.050418 Origin S Source natural TermSpec N-term MOD:00647 MOD:01458 PSI-MOD MOD:00061 N-acetyl-L-threonine A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 2106685 PubMed 6997045 PubMed AA0052 RESID PSI-MOD-slim (2S,3R)-2-acetamido-3-hydroxybutanoic acid RESID-systematic 2-acetylamino-3-hydroxybutanoic acid RESID-alternate 2-acetylazanyl-3-hydroxybutanoic acid RESID-alternate Acetyl PSI-MS-label Acetylation UniMod-description MOD_RES N-acetylthreonine UniProt-feature N-acetyl-L-threonine RESID-name N-acetylated L-threonine PSI-MOD-alternate N-acetylthreonine RESID-alternate N-methylcarbonylthreonine RESID-alternate NAcThr PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 6 H 10 N 1 O 3 MassAvg 144.15 MassMono 144.066068 Origin T Source natural TermSpec N-term MOD:01186 MOD:01458 PSI-MOD MOD:00062 N-acetyl-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 2506074 PubMed 475783 PubMed AA0053 RESID (2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid RESID-systematic 2-acetylamino-3-(4-hydoxyphenyl)propanoic acid RESID-alternate 2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid RESID-alternate Acetyl PSI-MS-label AcTyr PSI-MOD-label MOD_RES N-acetyltyrosine UniProt-feature N-acetyl-L-tyrosine RESID-name N-acetylated L-tyrosine PSI-MOD-alternate N-acetyltyrosine RESID-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 11 H 12 N 1 O 3 MassAvg 206.22 MassMono 206.081718 Origin Y Source natural TermSpec N-term MOD:00919 MOD:01458 PSI-MOD MOD:00063 N-acetyl-L-valine A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine. 1735421 PubMed AA0054 RESID PSI-MOD-slim (2S)-2-acetamido-3-methylbutanoic acid RESID-systematic 2-acetylamino-3-methylbutanoic acid RESID-alternate 2-acetylazanyl-3-methylbutanoic acid RESID-alternate AcVal PSI-MOD-label MOD_RES N-acetylvaline UniProt-feature N-acetyl-L-valine RESID-name N-acetylated L-valine PSI-MOD-alternate N-acetylvaline RESID-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 7 H 12 N 1 O 2 MassAvg 142.18 MassMono 142.086804 Origin V Source natural TermSpec N-term MOD:00920 MOD:01458 PSI-MOD MOD:00064 N6-acetyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine. 17752 ChEBI 214 DeltaMass 11369851 PubMed 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 1680872 PubMed 670159 PubMed AA0055 RESID 1#K UniMod PSI-MOD-slim (2S)-6-acetamido-2-aminohexanoic acid RESID-systematic 6-acetylamino-2-aminohexanoic acid RESID-alternate 6-acetylazanyl-2-aminohexanoic acid RESID-alternate Acetyl PSI-MS-label Acetylation UniMod-description acetylk OMSSA-label epsilon-acetyllysine RESID-alternate MOD_RES N6-acetyllysine UniProt-feature N(zeta)-acetyllysine RESID-alternate N6-acetyl-L-lysine RESID-name N6-acetylated L-lysine PSI-MOD-alternate N6AcLys PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 14 N 2 O 2 MassAvg 170.21 MassMono 170.105528 Origin K Source natural TermSpec none MOD:00723 MOD:01875 PSI-MOD MOD:00065 S-acetyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 1310545 PubMed 14730666 PubMed 15350136 PubMed AA0056 RESID 1#C UniMod PSI-MOD-slim (2R)-3-acetylsulfanyl-2-aminopropanoic acid RESID-systematic 2-amino-3-(acetylthio)propanoic acid RESID-alternate 2-azanyl-3-(acetylsulfanyl)propanoic acid RESID-alternate Acetyl PSI-MS-label Acetylation UniMod-description ACT_SITE S-acetylcysteine intermediate UniProt-feature cysteine acetate thioester RESID-alternate S-acetyl-L-cysteine RESID-name S-acetylcysteine RESID-alternate SAcCys PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 S 0 DiffMono 42.010565 Formula C 5 H 7 N 1 O 2 S 1 MassAvg 145.18 MassMono 145.019749 Origin C Source natural TermSpec none MOD:00645 MOD:00646 PSI-MOD MOD:00066 N-formylglycine A protein modification that effectively converts a glycine residue to N-formylglycine. 5139483 PubMed AA0057 RESID (formylamino)acetic acid RESID-alternate (formylamino)ethanoic acid RESID-systematic (formylazanyl)ethanoic acid RESID-alternate 2-formamidoacetic acid RESID-alternate 2-formamidoethanoic acid RESID-alternate MOD_RES N-formylglycine UniProt-feature N(alpha)-formylglycine RESID-alternate N-formylated glycine PSI-MOD-alternate N-formylglycine RESID-name NFoGly PSI-MOD-label DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 3 H 4 N 1 O 2 MassAvg 86.07 MassMono 86.024203 Origin G Source natural TermSpec N-term MOD:00409 MOD:00908 MOD:01696 PSI-MOD MOD:00067 N-D-glucuronoylglycine A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine. 10858503 PubMed 12716131 PubMed 6493057 PubMed 7398618 PubMed AA0058 RESID 2-(glucuronoylamino)ethanoic acid RESID-systematic Glucuronyl PSI-MS-label MOD_RES N-D-glucuronoyl glycine UniProt-feature N-D-glucuronoyl-glycine RESID-name N-D-glucuronyl-glycine RESID-alternate NGlcAGly PSI-MOD-label ntermpepglucuronylg OMSSA-label DiffAvg 176.12 DiffFormula C 6 H 8 N 0 O 6 DiffMono 176.032088 Formula C 8 H 12 N 1 O 7 MassAvg 234.18 MassMono 234.061377 Origin G Source natural TermSpec N-term MOD:00447 MOD:00908 PSI-MOD MOD:00068 N-myristoylglycine A protein modification that effectively converts a glycine residue to N-myristoylglycine. 11955007 PubMed 11955008 PubMed 1326520 PubMed 1386601 PubMed 6436247 PubMed 7543369 PubMed AA0059 RESID 45#G UniMod PSI-MOD-slim (tetradecanoylamino)ethanoic acid RESID-systematic LIPID N-myristoyl glycine UniProt-feature Myristoyl PSI-MS-label Myristoylation UniMod-description N-(1-oxotetradecyl)glycine RESID-alternate N-(C14:0 aliphatic acyl)glycine PSI-MOD-alternate N-myristoyl-glycine RESID-name N-myristoylated glycine PSI-MOD-alternate N-myristylglycine RESID-alternate N-tetradecanoylglycine RESID-alternate NMyrGly PSI-MOD-label ntermpepmyristoylationg OMSSA-label DiffAvg 210.36 DiffFormula C 14 H 26 N 0 O 1 DiffMono 210.198365 Formula C 16 H 30 N 1 O 2 MassAvg 268.42 MassMono 268.227654 Origin G Source natural TermSpec N-term MOD:00650 MOD:00908 MOD:01696 PSI-MOD MOD:00069 N-palmitoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine. 10896212 PubMed 4575979 PubMed 9056182 PubMed 9593755 PubMed AA0060 RESID incidental to RESID:AA0107 incidental to RESID:AA0309 PSI-MOD-slim (2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid RESID-systematic 2-hexadecanamido-3-sulfanylpropanoic acid RESID-alternate 2-hexadecanoylamino-3-mercaptopropanoic acid RESID-alternate LIPID N-palmitoyl cysteine UniProt-feature N-(1-oxahexadecyl)-L-cysteine RESID-alternate N-palmitoyl-L-cysteine RESID-name N-palmitoylated L-cysteine PSI-MOD-alternate NPamCys PSI-MOD-label Palmitoyl PSI-MS-label Palmitoylation UniMod-description DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 S 0 DiffMono 238.229666 Formula C 19 H 36 N 1 O 2 S 1 MassAvg 342.56 MassMono 342.246675 Origin C Source natural TermSpec N-term MOD:01684 MOD:01685 PSI-MOD MOD:00070 N-methyl-L-alanine A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine. 17519 ChEBI 323502 PubMed 337304 PubMed 7007074 PubMed AA0061 RESID Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. PSI-MOD-slim (2S)-2-methylaminopropanoic acid RESID-systematic 2-methylazanylpropanoic acid RESID-alternate Methyl PSI-MS-label Methylation UniMod-description MOD_RES N-methylalanine UniProt-feature N-methyl-L-alanine RESID-name N-methylalanine RESID-alternate N-methylated L-alanine PSI-MOD-alternate NMe1Ala PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 4 H 7 N 1 O 1 MassAvg 85.11 MassMono 85.052764 Origin A Source natural TermSpec none MOD:01461 MOD:01680 PSI-MOD MOD:00071 N,N,N-trimethyl-L-alanine A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine. 12590383 PubMed 332162 PubMed 3979397 PubMed 6778808 PubMed 7715456 PubMed AA0062 RESID PSI-MOD-slim (1S)-1-carboxy-N,N,N-trimethylethanaminium RESID-systematic (1S)-1-carboxy-N,N,N-trimethylethanazanium RESID-alternate (2S)-2-(trimethylammonio)propanoic acid RESID-alternate MOD_RES N,N,N-trimethylalanine UniProt-feature N,N,N-trimethyl-L-alanine RESID-name N,N,N-trimethylalanine cation RESID-alternate N,N,N-trimethylalaninium RESID-alternate N,N,N-trimethylated L-alanine PSI-MOD-alternate N2Me3+Ala PSI-MOD-label NMe3Ala PSI-MOD-label tri-Methylation UniMod-description Trimethyl PSI-MS-label DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 DiffMono 43.054227 FormalCharge 1+ Formula C 6 H 13 N 1 O 1 MassAvg 115.18 MassMono 115.099165 Origin A Source natural TermSpec N-term MOD:01461 MOD:01698 PSI-MOD MOD:00072 N-methylglycine A protein modification that effectively converts a glycine residue to N-methylglycine. 15611 ChEBI 0 DeltaMass 1593629 PubMed AA0063 RESID DeltaMass also has an entry for the free amino acid. Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. L-sarcosine RESID-alternate Methyl PSI-MS-label methylaminoacetic acid RESID-alternate methylaminoethanoic acid RESID-systematic Methylation UniMod-description N-methylated glycine PSI-MOD-alternate N-methylglycine RESID-name NMe1Gly PSI-MOD-label Sar DeltaMass-label Sarcosine DeltaMass-label Sarcosyl DeltaMass-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin G Source natural TermSpec none MOD:00570 MOD:00714 MOD:01680 PSI-MOD MOD:00073 N-methyl-L-methionine A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine. 169 DeltaMass 323502 PubMed 3298225 PubMed AA0064 RESID Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. PSI-MOD-slim (2S)-2-methylamino-4-(methylsulfanyl)butanoic acid RESID-systematic 2-methylamino-4-(methylthio)butanoic acid RESID-alternate Methyl PSI-MS-label Methyl Methionyl DeltaMass-label Methylation UniMod-description MOD_RES N-methylmethionine UniProt-feature N-methyl-L-methionine RESID-name N-methylated L-methionine PSI-MOD-alternate N-methylmethionine RESID-alternate NMe1Met PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 S 0 DiffMono 14.015650 Formula C 6 H 11 N 1 O 1 S 1 MassAvg 145.22 MassMono 145.056135 Origin M Source natural TermSpec none MOD:01463 MOD:01680 PSI-MOD MOD:00074 N-methyl-L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine. 2577730 PubMed 413571 PubMed AA0065 RESID Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. PSI-MOD-slim (2S)-2-methylamino-3-phenylpropanoic acid RESID-systematic Methyl PSI-MS-label Methylation UniMod-description MOD_RES N-methylphenylalanine UniProt-feature N-methyl-L-phenylalanine RESID-name N-methylated L-phenylalanine PSI-MOD-alternate N-methylphenylalanine RESID-alternate NMe1Phe PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 10 H 11 N 1 O 1 MassAvg 161.20 MassMono 161.084064 Origin F Source natural TermSpec none MOD:01063 MOD:01680 PSI-MOD MOD:00075 N,N-dimethyl-L-proline A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline. 21451 ChEBI 12964758 PubMed 14570711 PubMed 193025 PubMed 3882426 PubMed 6254758 PubMed AA0066 RESID 529 UniMod UniMod terminal specification corrected [JSG]. PSI-MOD-slim (2S)-2-carboxy-1,1-dimethylpyrrolidinium RESID-systematic 1,1-dimethyl-L-prolinium RESID-alternate Delta:H(5)C(2) UniMod-interim Dimethyl PSI-MS-label Dimethylation of proline residue UniMod-description MOD_RES N,N-dimethylproline UniProt-feature N,N-dimethyl-L-proline RESID-name N,N-dimethyl-L-prolinium RESID-alternate N,N-dimethylated L-proline PSI-MOD-alternate NMe2Pro PSI-MOD-label stachydrin RESID-alternate DiffAvg 29.06 DiffFormula C 2 H 5 N 0 O 0 DiffMono 29.038577 FormalCharge 1+ Formula C 7 H 13 N 1 O 1 MassAvg 127.19 MassMono 127.099165 Origin P Source natural TermSpec N-term MOD:00710 MOD:01462 PSI-MOD MOD:00076 symmetric dimethyl-L-arginine A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine. 12964758 PubMed 14570711 PubMed 15835918 PubMed 2426402 PubMed 5128665 PubMed AA0067 RESID 36#R UniMod PSI-MOD-slim (2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid RESID-systematic di-Methylation UniMod-description Dimethyl PSI-MS-label MOD_RES Omega-N-methylated arginine UniProt-feature MOD_RES Symmetric dimethylarginine UniProt-feature N3,N4-dimethylarginine RESID-alternate N5-[(methylamino)(methylimino)methyl]ornithine RESID-alternate NG,N'G-dimethylarginine RESID-alternate NoNo'Me2Arg PSI-MOD-label omega-N,omega-N'-dimethyl-L-arginine RESID-name omega-N,omega-N'-dimethylated L-arginine PSI-MOD-alternate symmetric dimethylarginine RESID-alternate DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 16 N 4 O 1 MassAvg 184.24 MassMono 184.132411 Origin R Source natural TermSpec none MOD:00602 MOD:00783 PSI-MOD MOD:00077 asymmetric dimethyl-L-arginine A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine. 17929 ChEBI 11152131 PubMed 12964758 PubMed 14570711 PubMed 15835918 PubMed 3032834 PubMed AA0068 RESID 36#R UniMod PSI-MOD-slim (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid RESID-systematic asymmetric dimethylarginine RESID-alternate di-Methylation UniMod-description Dimethyl PSI-MS-label MOD_RES Asymmetric dimethylarginine UniProt-feature MOD_RES Omega-N-methylated arginine UniProt-feature N5-[(dimethylamino)(imino)methyl]ornithine RESID-alternate NG,NG-dimethylarginine RESID-alternate NoNoMe2Arg PSI-MOD-label omega-N,omega-N-dimethlyated L-arginine PSI-MOD-alternate omega-N,omega-N-dimethyl-L-arginine RESID-name DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 16 N 4 O 1 MassAvg 184.24 MassMono 184.132411 Origin R Source natural TermSpec none MOD:00602 MOD:00783 PSI-MOD MOD:00078 omega-N-methyl-L-arginine A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine. 11875433 PubMed 15835918 PubMed 2426402 PubMed 5128665 PubMed AA0069 RESID PSI-MOD-slim (2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid RESID-systematic Methyl PSI-MS-label Methylation UniMod-description MOD_RES Omega-N-methylarginine UniProt-feature MOD_RES Omega-N-methylated arginine UniProt-feature NG-methylarginine RESID-alternate NoMeArg PSI-MOD-label omega-N-methyl-L-arginine RESID-name omega-N-methylated L-arginine PSI-MOD-alternate DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 14 N 4 O 1 MassAvg 170.22 MassMono 170.116761 Origin R Source natural TermSpec none MOD:00414 MOD:00602 PSI-MOD MOD:00079 N4-methyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine. 11875433 PubMed 2356973 PubMed 3782095 PubMed AA0070 RESID 34#N UniMod PSI-MOD-slim (2S)-2-amino-N4-methylbutanediamic acid RESID-systematic beta-aspartyl methylamide RESID-alternate beta-methylasparagine RESID-misnomer Methyl PSI-MS-label Methylation UniMod-description methyln OMSSA-label MOD_RES N4-methylasparagine UniProt-feature N(gamma)-methylasparagine RESID-alternate N-methylasparagine RESID-alternate N4-methyl-L-asparagine RESID-name N4-methylated L-asparagine PSI-MOD-alternate N4Me1Asn PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 5 H 8 N 2 O 2 MassAvg 128.13 MassMono 128.058578 Origin N Source natural TermSpec none MOD:00599 MOD:00602 MOD:00673 MOD:00894 PSI-MOD MOD:00080 N5-methyl-L-glutamine A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine. 17592 ChEBI 166 DeltaMass 11118225 PubMed 11875433 PubMed 365579 PubMed AA0071 RESID PSI-MOD-slim (2S)-2-amino-5-methylamino-5-oxopentanoic acid RESID-systematic 2-amino-N5-methylpentanediamic acid RESID-alternate gamma-methylglutamine RESID-alternate Methyl PSI-MS-label Methylation UniMod-description MOD_RES N5-methylglutamine UniProt-feature N(delta)-methylglutamine RESID-alternate N-methylglutamine RESID-alternate N5-methyl-L-glutamine RESID-name N5-methylated L-glutamine PSI-MOD-alternate N5Me1Gln PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 6 H 10 N 2 O 2 MassAvg 142.16 MassMono 142.074228 Origin Q Source natural TermSpec none MOD:00602 MOD:00722 PSI-MOD MOD:00081 L-glutamic acid 5-methyl ester (Glu) A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester. 167 DeltaMass 16888 PubMed 6300110 PubMed AA0072#GLU RESID 34#E UniMod DeltaMass gives the formula "C 6 H 9 O 1 N 3" with mass 143 (formula incorrect, N and O reversed) [JSG]. PSI-MOD-slim (2S)-2-amino-5-methoxy-5-oxopentanoic acid RESID-systematic (5)-methyl L-hydrogen glutamate RESID-alternate 2-aminopentanedioic acid 5-methyl ester RESID-alternate 5-methyl esterified L-glutamic acid PSI-MOD-alternate 5-methyl L-2-aminoglutarate RESID-alternate 5-methyl L-glutamate RESID-alternate glutamic acid 5-methyl ester RESID-alternate glutamic acid gamma-methyl ester RESID-alternate L-glutamic acid 5-methyl ester RESID-name meestere OMSSA-label Methyl PSI-MS-label methyl ester UniMod-alternate Methylation UniMod-description methyle OMSSA-label MOD_RES Glutamate methyl ester (Glu) UniProt-feature O-methyl Glutamyl DeltaMass-label O5MeGlu PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 6 H 9 N 1 O 3 MassAvg 143.14 MassMono 143.058243 Origin E Source natural TermSpec none MOD:01453 PSI-MOD MOD:00082 3'-methyl-L-histidine A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine). 10660523 PubMed 11875433 PubMed 3467365 PubMed 6692818 PubMed 8076 PubMed 8645219 PubMed AA0073 RESID PSI-MOD-slim (2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid RESID-systematic 1-methylhistidine RESID-misnomer 3'-methyl-L-histidine RESID-name Methyl PSI-MS-label Methylation UniMod-description MOD_RES Pros-methylhistidine UniProt-feature N(delta)-methylhistidine RESID-alternate N(pi)-methylhistidine RESID-alternate NpMeHis PSI-MOD-label pros-methylated L-histidine PSI-MOD-alternate pros-methylhistidine RESID-alternate DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 9 N 3 O 1 MassAvg 151.17 MassMono 151.074562 Origin H Source natural TermSpec none MOD:00724 PSI-MOD MOD:00083 N6,N6,N6-trimethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine. 17311 ChEBI 12590383 PubMed 3145979 PubMed 4304194 PubMed 6778808 PubMed 7093227 PubMed 8453381 PubMed AA0074 RESID DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine; for trimethylated lysine starting from protonated lysine see MOD:00855 PSI-MOD-slim (5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium RESID-systematic 2-amino-6-(trimethylammonio)hexanoic acid RESID-alternate 5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium RESID-alternate epsilon-trimethyllysine RESID-alternate MOD_RES N6,N6,N6-trimethyllysine UniProt-feature N(zeta)-trimethyllysine RESID-alternate N-trimethylation (of lysine) DeltaMass-label N6,N6,N6-trimethyl-L-lysine RESID-name N6,N6,N6-trimethylated L-lysine PSI-MOD-alternate N6,N6,N6-trimethyllysin-N6-ium RESID-alternate N6,N6,N6-trimethyllysine cation RESID-alternate N6Me3+Lys PSI-MOD-label tri-Methylation UniMod-description Trimethyl PSI-MS-label DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 DiffMono 43.054227 FormalCharge 1+ Formula C 9 H 19 N 2 O 1 MassAvg 171.26 MassMono 171.149190 Origin K Source natural TermSpec none MOD:00602 MOD:00663 MOD:00711 PSI-MOD MOD:00084 N6,N6-dimethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine. 10550045 PubMed 12964758 PubMed 14570711 PubMed 3100523 PubMed 8453381 PubMed AA0075 RESID 36#K UniMod PSI-MOD-slim (2S)-2-amino-6-(dimethylamino)hexanoic acid RESID-systematic di-Methylation UniMod-description Dimethyl PSI-MS-label dimethylk OMSSA-label epsilon-dimethyllysine RESID-alternate lysine derivative Lys(y) RESID-alternate MOD_RES N6,N6-dimethyllysine UniProt-feature N(zeta)-dimethyllysine RESID-alternate N6,N6-dimethyl-L-lysine RESID-name N6,N6-dimethylated L-lysine PSI-MOD-alternate N6Me2Lys PSI-MOD-label DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 16 N 2 O 1 MassAvg 156.23 MassMono 156.126263 Origin K Source natural TermSpec none MOD:00429 MOD:00602 MOD:00663 PSI-MOD MOD:00085 N6-methyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. 17604 ChEBI 165 DeltaMass 11875433 PubMed 3926756 PubMed AA0076 RESID 34#K UniMod PSI-MOD-slim (2S)-2-amino-6-methylaminohexanoic acid RESID-systematic epsilon-methyllysine RESID-alternate Methyl PSI-MS-label Methylation UniMod-description MOD_RES N6-methyllysine UniProt-feature N(zeta)-methyllysine RESID-alternate N-methyl Lysyl DeltaMass-label N6-methyl-L-lysine RESID-name N6-methylated L-lysine PSI-MOD-alternate N6Me1Lys PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 14 N 2 O 1 MassAvg 142.20 MassMono 142.110613 Origin K Source natural TermSpec none MOD:00602 MOD:01683 PSI-MOD MOD:00086 N6-palmitoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine. 2498336 PubMed 7801126 PubMed 7939682 PubMed AA0077 RESID 47#K UniMod PSI-MOD-slim (2S)-2-amino-6-(hexadecanoylamino)hexanoic acid RESID-systematic 2-amino-6-(hexadecanamido)hexanoic acid RESID-alternate epsilon-palmitoyllysine RESID-alternate LIPID N6-palmitoyl lysine UniProt-feature N(zeta)-palmitoyllysine RESID-alternate N6-(1-oxohexadecyl)-L-lysine RESID-alternate N6-palmitoyl-L-lysine RESID-name N6-palmitoylated L-lysine PSI-MOD-alternate N6PamLys PSI-MOD-label Palmitoyl PSI-MS-label Palmitoylation UniMod-description palmitoylationk OMSSA-label DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 DiffMono 238.229666 Formula C 22 H 42 N 2 O 2 MassAvg 366.59 MassMono 366.324629 Origin K Source natural TermSpec none MOD:00651 MOD:01875 PSI-MOD MOD:00087 N6-myristoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine. 1402651 PubMed 8346241 PubMed AA0078 RESID 45#K UniMod PSI-MOD-slim (2S)-2-amino-6-(tetradecanoylamino)hexanoic acid RESID-systematic 2-amino-6-(tetradecanamido)hexanoic acid RESID-alternate epsilon-myristoyllysine RESID-alternate LIPID N6-myristoyl lysine UniProt-feature Myristoyl PSI-MS-label Myristoylation UniMod-description myristoylationk OMSSA-label N(zeta)-myristoyllysine RESID-alternate N6-(1-oxotetradecyl)-L-lysine RESID-alternate N6-(C14:0 aliphatic acyl)lysine PSI-MOD-alternate N6-myristoyl-L-lysine RESID-name N6-myristoylated L-lysine PSI-MOD-alternate N6MyrLys PSI-MOD-label DiffAvg 210.36 DiffFormula C 14 H 26 N 0 O 1 DiffMono 210.198365 Formula C 20 H 38 N 2 O 2 MassAvg 338.54 MassMono 338.293328 Origin K Source natural TermSpec none MOD:00650 MOD:01875 PSI-MOD MOD:00088 O-palmitoyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine. 6642431 PubMed 8413602 PubMed AA0079 RESID 47#T UniMod PSI-MOD-slim (2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid RESID-systematic L-threonine hexadecanoate ester RESID-alternate LIPID O-palmitoyl threonine UniProt-feature O-palmitoyl-L-threonine RESID-name O-palmitoylated L-threonine PSI-MOD-alternate O3-palmitoyl-threonine RESID-alternate OPamThr PSI-MOD-label Palmitoyl PSI-MS-label Palmitoylation UniMod-description palmitoylationt OMSSA-label threonine palmitate ester RESID-alternate DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 DiffMono 238.229666 Formula C 20 H 37 N 1 O 3 MassAvg 339.52 MassMono 339.277344 Origin T Source natural TermSpec none MOD:00652 MOD:00917 PSI-MOD MOD:00089 O-palmitoyl-L-serine A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine. 3467339 PubMed AA0080 RESID 47#S UniMod PSI-MOD-slim (2S)-2-amino-3-(hexadecanoyloxy)propanoic acid RESID-systematic ACT_SITE O-palmitoyl serine intermediate UniProt-feature L-serine hexadecanoate ester RESID-alternate LIPID O-palmitoyl serine UniProt-feature O-palmitoyl-L-serine RESID-name O-palmitoylated L-serine PSI-MOD-alternate O3-palmitoyl-serine RESID-alternate OPamSer PSI-MOD-label Palmitoyl PSI-MS-label Palmitoylation UniMod-description palmitoylations OMSSA-label serine palmitate ester RESID-alternate DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 DiffMono 238.229666 Formula C 19 H 35 N 1 O 3 MassAvg 325.49 MassMono 325.261694 Origin S Source natural TermSpec none MOD:00652 MOD:00916 PSI-MOD MOD:00090 L-alanine amide A protein modification that effectively converts an L-alanine residue to L-alanine amide. 1377792 PubMed 2069951 PubMed 8472537 PubMed 952951 PubMed AA0081 RESID PSI-MOD-slim (2S)-2-aminopropanamide RESID-systematic AlaN PSI-MOD-label alaninamide RESID-alternate amidated L-alanine PSI-MOD-alternate L-alanine amide RESID-name MOD_RES Alanine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 3 H 7 N 2 O 1 MassAvg 87.10 MassMono 87.055838 Origin A Source natural TermSpec C-term MOD:00883 MOD:00901 PSI-MOD MOD:00091 L-arginine amide A protein modification that effectively converts an L-arginine residue to L-arginine amide. 2229025 PubMed 2753890 PubMed 743209 PubMed AA0082 RESID PSI-MOD-slim (2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide RESID-systematic 2-amino-5-carbamimidamidopentanamide RESID-alternate 2-amino-5-guanidinopentanamide RESID-alternate amidated L-arginine PSI-MOD-alternate argininamide RESID-alternate ArgN PSI-MOD-label L-arginine amide RESID-name MOD_RES Arginine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 14 N 5 O 1 MassAvg 172.21 MassMono 172.119835 Origin R Source natural TermSpec C-term MOD:00883 MOD:00902 PSI-MOD MOD:00092 L-asparagine amide A protein modification that effectively converts an L-asparagine residue to L-asparagine amide. 2753132 PubMed 279902 PubMed 3415690 PubMed AA0083 RESID PSI-MOD-slim (2S)-2-aminobutanediamide RESID-systematic amidated L-asparagine PSI-MOD-alternate AsnN PSI-MOD-label asparaginamide RESID-alternate L-asparagine amide RESID-name MOD_RES Asparagine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 4 H 8 N 3 O 2 MassAvg 130.13 MassMono 130.061652 Origin N Source natural TermSpec C-term MOD:00883 MOD:00903 PSI-MOD MOD:00093 L-aspartic acid 1-amide A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide. 2542051 PubMed AA0084 RESID PSI-MOD-slim (2S)-2-amino-1-butanediamic acid RESID-systematic 1-amidated L-aspartic acid PSI-MOD-alternate 3,4-diamino-4-oxobutanoic acid RESID-alternate 3-amino-succinamic acid RESID-alternate alpha-asparagine RESID-alternate AspN PSI-MOD-label isoasparagine RESID-alternate L-aspartic acid 1-amide RESID-name MOD_RES Aspartic acid 1-amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 4 H 7 N 2 O 3 MassAvg 131.11 MassMono 131.045667 Origin D Source natural TermSpec C-term MOD:00883 MOD:00904 PSI-MOD MOD:00094 L-cysteine amide A protein modification that effectively converts an L-cysteine residue to L-cysteine amide. 1892838 PubMed 7149738 PubMed AA0085 RESID PSI-MOD-slim (2R)-2-amino-3-sulfanylpropanamide RESID-systematic 2-amino-3-mercaptopropanamide RESID-alternate amidated L-cysteine PSI-MOD-alternate CysN PSI-MOD-label cysteinamide RESID-alternate L-cysteine amide RESID-name MOD_RES Cysteine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 S 0 DiffMono -0.984016 Formula C 3 H 7 N 2 O 1 S 1 MassAvg 119.16 MassMono 119.027909 Origin C Source natural TermSpec C-term MOD:00883 MOD:00905 PSI-MOD MOD:00095 L-glutamine amide A protein modification that effectively converts an L-glutamine residue to L-glutamine amide. 7673220 PubMed 9048550 PubMed AA0086 RESID PSI-MOD-slim (2S)-2-aminopentanediamide RESID-systematic amidated L-glutamine PSI-MOD-alternate GlnN PSI-MOD-label glutaminamide RESID-alternate L-glutamine amide RESID-name MOD_RES Glutamine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 5 H 10 N 3 O 2 MassAvg 144.15 MassMono 144.077302 Origin Q Source natural TermSpec C-term MOD:00883 MOD:00907 PSI-MOD MOD:00096 L-glutamic acid 1-amide A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide. 1093875 PubMed 14550575 PubMed AA0087 RESID PSI-MOD-slim (2S)-2-amino-1-pentanediamic acid RESID-systematic 1-amidated L-glutamic acid PSI-MOD-alternate 4,5-diamino-5-oxopentanoic acid RESID-alternate GluN PSI-MOD-label isoglutamine RESID-alternate L-glutamic acid 1-amide RESID-name MOD_RES Glutamic acid 1-amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 5 H 9 N 2 O 3 MassAvg 145.14 MassMono 145.061317 Origin E Source natural TermSpec C-term MOD:00883 MOD:00906 PSI-MOD MOD:00097 glycine amide A protein modification that effectively converts a glycine residue to glycine amide. 13591312 PubMed AA0088 RESID PSI-MOD-slim 2-aminoacetamide RESID-alternate 2-aminoethanamide RESID-systematic 2-azanylethanamide RESID-alternate amidated glycine PSI-MOD-alternate glycinamide RESID-alternate glycine amide RESID-name GlyN PSI-MOD-label MOD_RES Glycine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 2 H 5 N 2 O 1 MassAvg 73.07 MassMono 73.040188 Origin G Source natural TermSpec C-term MOD:00883 MOD:00908 PSI-MOD MOD:00098 L-histidine amide A protein modification that effectively converts an L-histidine residue to L-histidine amide. 2153586 PubMed 2307683 PubMed 2839478 PubMed AA0089 RESID PSI-MOD-slim (2S)-2-amino-3-(1H-imidazol-4-yl)propanamide RESID-systematic amidated L-histidine PSI-MOD-alternate HisN PSI-MOD-label histidinamide RESID-alternate L-histidine amide RESID-name MOD_RES Histidine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 9 N 4 O 1 MassAvg 153.16 MassMono 153.077636 Origin H Source natural TermSpec C-term MOD:00883 MOD:00909 PSI-MOD MOD:00099 L-isoleucine amide A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide. AA0090 RESID PSI-MOD-slim (2S,3S)-2-amino-3-methylpentanamide RESID-systematic amidated L-isoleucine PSI-MOD-alternate IleN PSI-MOD-label isoleucinamide RESID-alternate L-isoleucine amide RESID-name MOD_RES Isoleucine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 13 N 2 O 1 MassAvg 129.18 MassMono 129.102788 Origin I Source natural TermSpec C-term MOD:00883 MOD:00910 PSI-MOD MOD:00100 L-leucine amide A protein modification that effectively converts an L-leucine residue to L-leucine amide. 2578459 PubMed AA0091 RESID PSI-MOD-slim (2S)-2-amino-4-methylpentanamide RESID-systematic 2-amino-4-methylvaleramide RESID-alternate 2-azanyl-4-methylpentanamide RESID-alternate alpha-aminoisocaproamide RESID-alternate amidated L-leucine PSI-MOD-alternate L-leucine amide RESID-name leucinamide RESID-alternate LeuN PSI-MOD-label MOD_RES Leucine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 13 N 2 O 1 MassAvg 129.18 MassMono 129.102788 Origin L Source natural TermSpec C-term MOD:00883 MOD:00911 PSI-MOD MOD:00101 L-lysine amide A protein modification that effectively converts an L-lysine residue to L-lysine amide. 6579533 PubMed AA0092 RESID PSI-MOD-slim (2S)-2,6-diaminohexanamide RESID-systematic amidated L-lysine PSI-MOD-alternate L-lysine amide RESID-name lysinamide RESID-alternate LysN PSI-MOD-label MOD_RES Lysine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 6 H 14 N 3 O 1 MassAvg 144.20 MassMono 144.113687 Origin K Source natural TermSpec C-term MOD:00883 MOD:00912 PSI-MOD MOD:00102 L-methionine amide A protein modification that effectively converts an L-methionine residue to L-methionine amide. 4375977 PubMed AA0093 RESID PSI-MOD-slim (2S)-2-amino-4-(methylsulfanyl)butanamide RESID-systematic 2-amino-4-(methylthio)butanamide RESID-alternate amidated L-methionine PSI-MOD-alternate L-methionine amide RESID-name methioninamide RESID-alternate MetN PSI-MOD-label MOD_RES Methionine amide UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 S 0 DiffMono -0.984016 Formula C 5 H 11 N 2 O 1 S 1 MassAvg 147.22 MassMono 147.059209 Origin M Source natural TermSpec C-term MOD:00883 MOD:00913 PSI-MOD MOD:00103 L-phenylalanine amide A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide. 2905621 PubMed 8868490 PubMed AA0094 RESID PSI-MOD-slim (2S)-2-amino-3-phenylpropanamide RESID-systematic amidated L-phenylalanine PSI-MOD-alternate L-phenylalanine amide RESID-name MOD_RES Phenylalanine amide UniProt-feature PheN PSI-MOD-label phenylalaninamide RESID-alternate DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 9 H 11 N 2 O 1 MassAvg 163.20 MassMono 163.087138 Origin F Source natural TermSpec C-term MOD:00883 MOD:00914 PSI-MOD MOD:00104 L-proline amide A protein modification that effectively converts an L-proline residue to L-proline amide. 4982117 PubMed 5760861 PubMed AA0095 RESID PSI-MOD-slim (2S)-pyrrolidine-2-carboxamide RESID-systematic amidated L-proline PSI-MOD-alternate L-proline amide RESID-name MOD_RES Proline amide UniProt-feature prolinamide RESID-alternate ProN PSI-MOD-label DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 5 H 9 N 2 O 1 MassAvg 113.14 MassMono 113.071488 Origin P Source natural TermSpec C-term MOD:00883 MOD:00915 PSI-MOD MOD:00105 L-serine amide A protein modification that effectively converts an L-serine residue to L-serine amide. 743209 PubMed AA0096 RESID PSI-MOD-slim (2S)-2-amino-3-hydroxypropanamide RESID-systematic amidated L-serine PSI-MOD-alternate L-serine amide RESID-name MOD_RES Serine amide UniProt-feature serinamide RESID-alternate SerN PSI-MOD-label DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 3 H 7 N 2 O 2 MassAvg 103.10 MassMono 103.050752 Origin S Source natural TermSpec C-term MOD:00883 MOD:00916 PSI-MOD MOD:00106 L-threonine amide A protein modification that effectively converts an L-threonine residue to L-threonine amide. 1390774 PubMed AA0097 RESID PSI-MOD-slim (2S,3R)-2-amino-3-hydroxybutanamide RESID-systematic amidated L-threonine PSI-MOD-alternate L-threonine amide RESID-name MOD_RES Threonine amide UniProt-feature threoninamide RESID-alternate ThrN PSI-MOD-label DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 4 H 9 N 2 O 2 MassAvg 117.13 MassMono 117.066403 Origin T Source natural TermSpec C-term MOD:00883 MOD:00917 PSI-MOD MOD:00107 L-tryptophan amide A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide. 3947348 PubMed AA0098 RESID PSI-MOD-slim (2S)-2-amino-3-(1H-indol-3-yl)propanamide RESID-systematic amidated L-tryptophan PSI-MOD-alternate L-tryptophan amide RESID-name MOD_RES Tryptophan amide UniProt-feature TrpN PSI-MOD-label tryptophanamide RESID-alternate DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 11 H 12 N 3 O 1 MassAvg 202.24 MassMono 202.098037 Origin W Source natural TermSpec C-term MOD:00883 MOD:00918 PSI-MOD MOD:00108 L-tyrosine amide A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide. 1377792 PubMed 3562898 PubMed 6509012 PubMed AA0099 RESID PSI-MOD-slim (2S)-2-amino-3-(4-hydoxyphenyl)propanamide RESID-systematic amidated L-tyrosine PSI-MOD-alternate L-tyrosine amide RESID-name MOD_RES Tyrosine amide UniProt-feature TyrN PSI-MOD-label tyrosinamide RESID-alternate DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 9 H 11 N 2 O 2 MassAvg 179.20 MassMono 179.082053 Origin Y Source natural TermSpec C-term MOD:00883 MOD:00919 PSI-MOD MOD:00109 L-valine amide A protein modification that effectively converts an L-valine residue to L-valine amide. 2578459 PubMed 5465996 PubMed AA0100 RESID PSI-MOD-slim (2S)-2-amino-3-methylbutanamide RESID-systematic L-valine amide RESID-name MOD_RES Valine amide UniProt-feature valinamide RESID-alternate ValN PSI-MOD-label DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 5 H 11 N 2 O 1 MassAvg 115.16 MassMono 115.087138 Origin V Source natural TermSpec C-term MOD:00883 MOD:00920 PSI-MOD MOD:00110 L-cysteine methyl disulfide A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide. 10555576 PubMed 163643 PubMed 2056535 PubMed 6381494 PubMed AA0101 RESID 39#C UniMod Produced artifactually by reaction of cysteine residues with methyl methanethiosulfonate (MMTS) [JSG]. (2R)-2-amino-3-(methyldisulfanediyl)propanoic acid RESID-systematic 2-amino-3-(methyldisulfanediyl)propanoic acid RESID-alternate 2-amino-3-(methyldithio)propanoic acid RESID-alternate 2-amino-3-methyldisulfanylpropanoic acid RESID-alternate 2-azanyl-3-(methyldisulfanediyl)-propanoic acid RESID-alternate Beta-methylthiolation UniMod-description L-3-(methyldithio)alanine RESID-alternate L-cysteine methyl disulfide RESID-name methyl methanethiolsulfonate derivatized cysteine PSI-MOD-alternate methyl methanethiosulfonate derivatized cysteine PSI-MOD-alternate Methylthio PSI-MS-label Methylthio UniMod-interim mmts OMSSA-label MOD_RES Cysteine methyl disulfide UniProt-feature S-methylthio-L-cysteine RESID-alternate S-methylthiocysteine RESID-alternate DiffAvg 46.09 DiffFormula C 1 H 2 N 0 O 0 S 1 DiffMono 45.987721 Formula C 4 H 7 N 1 O 1 S 2 MassAvg 149.23 MassMono 148.996906 Origin C Source hypothetical TermSpec none MOD:00848 MOD:00905 MOD:01153 MOD:01862 PSI-MOD MOD:00111 S-farnesyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine. 293 DeltaMass 1409665 PubMed 15609361 PubMed 1872463 PubMed 2684976 PubMed AA0102 RESID 44#C UniMod From DeltaMass: (name misspelled "S-farnesyl cystenyl") PSI-MOD-slim (2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid RESID-systematic 2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid RESID-alternate Farnesyl PSI-MS-label Farnesylation UniMod-description farnesylationc OMSSA-label LIPID S-farnesyl cysteine UniProt-feature S-farnesyl Cystenyl DeltaMass-label S-farnesyl-L-cysteine RESID-name SFarnCys PSI-MOD-label DiffAvg 204.36 DiffFormula C 15 H 24 N 0 O 0 S 0 DiffMono 204.187801 Formula C 18 H 29 N 1 O 1 S 1 MassAvg 307.50 MassMono 307.196986 Origin C Source natural TermSpec none MOD:00437 MOD:01110 PSI-MOD MOD:00112 S-12-hydroxyfarnesyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine. 17790543 PubMed AA0103 RESID 376 UniMod (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid RESID-systematic 2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid RESID-alternate Hydroxyfarnesyl PSI-MS-label hydroxyfarnesyl UniMod-description LIPID S-12-hydroxyfarnesyl cysteine UniProt-feature S-12-hydroxyfarnesyl-L-cysteine RESID-name S12HyFarnCys PSI-MOD-label DiffAvg 220.36 DiffFormula C 15 H 24 N 0 O 1 S 0 DiffMono 220.182715 Formula C 18 H 29 N 1 O 2 S 1 MassAvg 323.50 MassMono 323.191900 Origin C Source natural TermSpec none MOD:01110 PSI-MOD MOD:00113 S-geranylgeranyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine. 0 DeltaMass 1483450 PubMed 15609361 PubMed AA0104 RESID 48#C UniMod DeltaMass calculates the mass with two double bonds rather than four PSI-MOD-slim (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid RESID-systematic 2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid RESID-alternate Geranyl-geranyl UniMod-description GeranylGeranyl PSI-MS-label geranylgeranylc OMSSA-label LIPID S-geranylgeranyl cysteine UniProt-feature S-geranylgeranyl DeltaMass-label S-geranylgeranyl-L-cysteine RESID-name SGergerCys PSI-MOD-label DiffAvg 272.48 DiffFormula C 20 H 32 N 0 O 0 S 0 DiffMono 272.250401 Formula C 23 H 37 N 1 O 1 S 1 MassAvg 375.62 MassMono 375.259586 Origin C Source natural TermSpec none MOD:00441 MOD:01110 PSI-MOD MOD:00114 L-cysteine methyl ester A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester. 11875433 PubMed 1872463 PubMed AA0105 RESID 34#C-term UniMod Secondary to RESID:AA0102; secondary to RESID:AA0103; secondary to RESID:AA0104. PSI-MOD-slim 2-amino-3-mercaptopropanoic methyl ester RESID-alternate 2-amino-3-sulfanylpropanoic methyl ester RESID-alternate L-cysteine methyl ester RESID-name mecysteine RESID-alternate Methyl PSI-MS-label methyl (2R)-2-amino-3-sulfanylpropanoate RESID-systematic methyl esterified L-cysteine PSI-MOD-alternate methyl L-cysteinate RESID-alternate Methylation UniMod-description MOD_RES Cysteine methyl ester UniProt-feature OMeCys PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 S 0 DiffMono 14.015650 Formula C 4 H 8 N 1 O 2 S 1 MassAvg 134.17 MassMono 134.027574 Origin C Source natural TermSpec C-term MOD:01682 MOD:01689 PSI-MOD MOD:00115 S-palmitoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine. 303 DeltaMass 1872406 PubMed 3166978 PubMed 8180229 PubMed 8824274 PubMed AA0106 RESID 47#C UniMod From DeltaMass: (name misspelled "S-palmityl Cystenyl" and formula incorrect, N and O reversed) Formula: C19H35O1N2S1 Monoisotopic Mass Change: 341.239 Average Mass Change: 341.556 PSI-MOD-slim (2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid RESID-systematic 2-amino-3-(hexadecanoylthio)propanoic acid RESID-alternate ACT_SITE S-palmitoyl cysteine intermediate UniProt-feature cysteine hexadecanoate thioester RESID-alternate cysteine palmitate thioester RESID-alternate LIPID S-palmitoyl cysteine UniProt-feature Palmitoyl PSI-MS-label Palmitoylation UniMod-description S-palmitoyl-L-cysteine RESID-name S-palmitoylated L-cysteine PSI-MOD-alternate S-palmityl Cystenyl DeltaMass-label SPamCys PSI-MOD-label DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 S 0 DiffMono 238.229666 Formula C 19 H 35 N 1 O 2 S 1 MassAvg 341.55 MassMono 341.238850 Origin C Source natural TermSpec none MOD:00653 MOD:01684 PSI-MOD MOD:00116 S-diacylglycerol-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine. 10896212 PubMed 4575979 PubMed 9056182 PubMed AA0107 RESID 377#C UniMod Incidental to RESID:AA0060. PSI-MOD-slim (2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid RESID-systematic 2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid RESID-alternate Diacylglycerol PSI-MS-label diacylglycerol UniMod-description LIPID S-diacylglycerol cysteine UniProt-feature S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine RESID-alternate S-(2',3'-diacylglycerol)-L-cysteine PSI-MOD-alternate S-diacylglycerol-L-cysteine RESID-name SAcyl2GlyceroCys PSI-MOD-label Origin C Source natural TermSpec none MOD:00905 MOD:01155 PSI-MOD MOD:00117 S-(L-isoglutamyl)-L-cysteine A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia. 22021 ChEBI 0 DeltaMass 6838833 PubMed AA0108 RESID Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine. PSI-MOD-slim (2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid RESID-systematic (S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid RESID-alternate 2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid RESID-alternate CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln) UniProt-feature gamma-(S-cysteinyl)glutamic acid RESID-alternate S-(L-isoglutamyl)-L-cysteine RESID-name S-gamma-glutamyl (crosslinked to cysteine) DeltaMass-label XLNK-SCys-5Glu(Gln) PSI-MOD-label DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 S 0 DiffMono -17.026549 Formula C 8 H 10 N 2 O 3 S 1 MassAvg 214.24 MassMono 214.041213 Origin C, Q Source natural TermSpec none MOD:00395 MOD:00907 MOD:00946 PSI-MOD MOD:00118 2'-(S-L-cysteinyl)-L-histidine A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine. 0 DeltaMass 6210696 PubMed AA0109 RESID Cross-link 2. (2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid RESID-systematic (2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid RESID-alternate 2'-(L-cystein-S-yl)-L-histidine RESID-name CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His) UniProt-feature S-(2'-histidyl)cysteine RESID-alternate S-(2-histidyl)- (crosslinked to cysteine) DeltaMass-label XLNK-SCys-2'His PSI-MOD-label DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 9 H 10 N 4 O 2 S 1 MassAvg 238.26 MassMono 238.052447 Origin C, H Source natural TermSpec none MOD:00687 MOD:00909 PSI-MOD MOD:00119 L-lanthionine (Cys-Ser) A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. 21347 ChEBI 7 DeltaMass AA0110#CSX RESID Cross-link 2. The natural occurrence of this modification is rare. For the more common modification see MOD:00120 meso-lanthionine [JSG]. (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) RESID-systematic (R)-S-(2-amino-2-carboxyethyl)-L-cysteine RESID-alternate (R,R)-2,6-diamino-4-thiaheptanedioic acid RESID-alternate (R,R)-3,3'-thiobis-(2-aminopropanoic acid) RESID-alternate (R,R)-bis(2-amino-2-carboxyethyl)sulfide RESID-alternate 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid RESID-alternate 3,3'-thiobis-L-alanine RESID-alternate L-lanthionine RESID-name XLNK-SCys-(L)3Dha PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030649 Origin C, S Source artifact TermSpec none MOD:00916 MOD:00954 MOD:01839 PSI-MOD MOD:00120 meso-lanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine. 15023056 PubMed 3769923 PubMed AA0111 RESID Cross-link 2. (2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid) RESID-systematic (2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid) RESID-alternate (2R,6S)-2,6-diamino-4-thiaheptanedioic acid RESID-alternate (2R,6S)-meso-lanthionine RESID-alternate (2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid RESID-alternate (2S,6R)-meso-lanthionine RESID-misnomer (R)-S-(2-amino-2-carboxyethyl)-D-cysteine RESID-alternate (R,S)-bis(2-amino-2-carboxyethyl)sulfide RESID-alternate 3,3'-thiobis-meso-alanine RESID-alternate CROSSLNK Lanthionine (Cys-Ser) UniProt-feature CROSSLNK Lanthionine (Ser-Cys) UniProt-feature cysteine-3-D-alanine thioether RESID-alternate meso-lanthionine RESID-name XLNK-SCys-(D)3Dha PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030649 Origin C, S Source natural TermSpec none MOD:00916 MOD:00954 MOD:01841 PSI-MOD MOD:00121 (2S,3S,2'R)-3-methyllanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine. 3769923 PubMed AA0112 RESID Cross-link 2. (2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid RESID-systematic (2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid RESID-alternate (2S,3S,2'R)-3-methyllanthionine RESID-name (2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid RESID-alternate (2S,3S,6R)-3-methyllanthionine RESID-alternate (2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid RESID-alternate 3-methyl-D,L-lanthionine RESID-alternate CROSSLNK Beta-methyllanthionine (Cys-Thr) UniProt-feature CROSSLNK Beta-methyllanthionine (Thr-Cys) UniProt-feature cysteine-3-D-butyrine thioether RESID-alternate XLNK-SCys-3Dhb PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 7 H 10 N 2 O 2 S 1 MassAvg 186.23 MassMono 186.046299 Origin C, T Source natural TermSpec none MOD:01981 PSI-MOD MOD:00122 3'-(S-L-cysteinyl)-L-tyrosine A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine. 0 DeltaMass 15917234 PubMed 2002850 PubMed AA0113 RESID Cross-link 2. (2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid RESID-systematic 2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid RESID-alternate 3'-(cystein-S-yl)tyrosine RESID-alternate 3'-(L-cystein-S-yl)-L-tyrosine RESID-name CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) UniProt-feature CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys) UniProt-feature S-(3-Tyr) (Crosslinked to Cysteine) DeltaMass-label S-(tyros-3'-yl)cysteine RESID-alternate XLNK-SCys-3'Tyr PSI-MOD-label DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 12 H 12 N 2 O 3 S 1 MassAvg 264.30 MassMono 264.056863 Origin C, Y Source natural TermSpec none MOD:00687 MOD:00919 PSI-MOD MOD:00123 N6-carboxy-L-lysine A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine. 11369851 PubMed 4436319 PubMed 637859 PubMed 7754395 PubMed AA0114 RESID 299#K UniMod PSI-MOD-slim (2S)-2-amino-6-(carboxyamino)hexanoic acid RESID-systematic 2-amino-6-carbamic hexanoic acid RESID-alternate Carboxy UniMod-interim Carboxylation UniMod-description lysine NZ-carboxylic acid RESID-alternate MOD_RES N6-carboxylysine UniProt-feature N6-carbamyllysine RESID-misnomer N6-carboxy-L-lysine RESID-name N6-carboxylysine RESID-alternate N6CbxLys PSI-MOD-label DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 DiffMono 43.989829 Formula C 7 H 12 N 2 O 3 MassAvg 172.18 MassMono 172.084792 Origin K Source natural TermSpec none MOD:00912 MOD:01152 PSI-MOD MOD:00124 N6-1-carboxyethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine. 3123486 PubMed 8253186 PubMed 8421682 PubMed AA0115 RESID 378#K UniMod PSI-MOD-slim (2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid RESID-systematic Carboxyethyl PSI-MS-label carboxyethyl UniMod-description MOD_RES N6-1-carboxyethyl lysine UniProt-feature N6-(1-carboxyethyl)-L-lysine RESID-name N6-(1-carboxyethyl)lysine RESID-alternate N6CbzEtLys PSI-MOD-label NZ-(1-carboxyethyl)lysine RESID-alternate DiffAvg 72.06 DiffFormula C 3 H 4 N 0 O 2 DiffMono 72.021129 Formula C 9 H 16 N 2 O 3 MassAvg 200.24 MassMono 200.116092 Origin K Source natural TermSpec none MOD:00912 PSI-MOD MOD:00125 hypusine A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. 0 DeltaMass 6806267 PubMed 8108861 PubMed AA0116 RESID 379#K UniMod This modification occurs uniquely in translation initiation factor eIF-5A [JSG]. PSI-MOD-slim (2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid RESID-systematic (2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid RESID-alternate (2S,9R)-hypusine RESID-alternate 2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid RESID-alternate Hypu PSI-MOD-label Hypusine PSI-MS-label hypusine UniMod-description L-hypusine RESID-name MOD_RES Hypusine UniProt-feature N-(4-NH2-2-OH-butyl)- (of Lysine) DeltaMass-label N6-(4-amino-2-hydroxybutyl)-L-lysine RESID-alternate DiffAvg 87.12 DiffFormula C 4 H 9 N 1 O 1 DiffMono 87.068414 Formula C 10 H 21 N 3 O 2 MassAvg 215.30 MassMono 215.163377 Origin K Source natural TermSpec none MOD:00912 MOD:01884 derives_from MOD:018800 PSI-MOD MOD:00126 N6-biotinyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine. 305 DeltaMass 16109483 PubMed 3178228 PubMed 7948875 PubMed 8747466 PubMed AA0117 RESID 3#K UniMod From DeltaMass: Average Mass: 354 Formula:C 16 H 26 O 4 N 3 S 1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:354.172 Average Mass Change:354.471 References:PE Sciex. PSI-MOD-slim (2S)-2-amino-6-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoylamino)hexanoic acid RESID-systematic (3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine RESID-alternate biocytin RESID-alternate Biotin PSI-MS-label biotinyl lysyl DeltaMass-label Biotinylation UniMod-description epsilon-N-biotinyllysine RESID-alternate MOD_RES N6-biotinyllysine UniProt-feature N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine RESID-alternate N6-biotinyl-L-lysine RESID-name N6-biotinyllysine RESID-alternate N6BtnLys PSI-MOD-label DiffAvg 226.29 DiffFormula C 10 H 14 N 2 O 2 S 1 DiffMono 226.077599 Formula C 16 H 26 N 4 O 3 S 1 MassAvg 354.47 MassMono 354.172562 Origin K Source natural TermSpec none MOD:01875 MOD:01885 PSI-MOD MOD:00127 N6-lipoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine. 0 DeltaMass 3421911 PubMed 3522581 PubMed 7719855 PubMed AA0118 RESID 42#K UniMod PSI-MOD-slim (2S)-2-amino-6-(5-[(3R)-1,2-dithiolan-3-yl]pentanamido)hexanoic acid RESID-alternate (2S)-2-amino-6-[(5-[(3R)-1,2-dithiolan-3-yl]pentanoyl)amino]hexanoic acid RESID-systematic (2S,6'R)-2-amino-6-(6,8-dithiooctanamido)hexanoic acid RESID-alternate 2-amino-6-(5-[1,2-dithiolan-3-yl]-1-oxopentyl)aminohexanoic acid RESID-alternate Lipoyl PSI-MS-label Lipoyl UniMod-description lipoylk OMSSA-label MOD_RES N6-lipoyllysine UniProt-feature N-Lipoyl- (on Lysine) DeltaMass-label N6-6,8-dithiooctanoyllysine RESID-alternate N6-lipoyl-L-lysine RESID-name N6-lipoyllysine RESID-alternate N6LipLys PSI-MOD-label DiffAvg 188.30 DiffFormula C 8 H 12 N 0 O 1 S 2 DiffMono 188.032957 Formula C 14 H 24 N 2 O 2 S 2 MassAvg 316.48 MassMono 316.127920 Origin K Source natural TermSpec none MOD:01875 PSI-MOD MOD:00128 N6-pyridoxal phosphate-L-lysine A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine. 0 DeltaMass 1544460 PubMed AA0119 RESID 46#K UniMod From DeltaMass: Average Mass: 231 PSI-MOD-slim (2S)-2-amino-6-[([3-hydroxy-2-methyl-5-phosphonooxymethylpyridin-4-yl]methylidene)amino]hexanoic acid RESID-systematic MOD_RES N6-(pyridoxal phosphate)lysine UniProt-feature N6-pyridoxal phosphate-L-lysine RESID-name N6PydoxLys PSI-MOD-label Pyridoxal phosphate UniMod-description Pyridoxal phosphate (Schiff Base formed to lysine) DeltaMass-label PyridoxalPhosphate PSI-MS-label DiffAvg 229.13 DiffFormula C 8 H 8 N 1 O 5 P 1 DiffMono 229.014009 Formula C 14 H 20 N 3 O 6 P 1 MassAvg 357.30 MassMono 357.108972 Origin K Source natural TermSpec none MOD:00912 PSI-MOD MOD:00129 N6-retinylidene-L-lysine A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine, the adduct of retinal. 6794028 PubMed 6870827 PubMed AA0120 RESID 380#K UniMod PSI-MOD-slim (2S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid RESID-systematic MOD_RES N6-(retinylidene)lysine UniProt-feature N6-retinal-L-lysine RESID-alternate N6-retinyl-lysine RESID-alternate N6-retinylidene-L-lysine RESID-name N6RetalLys PSI-MOD-label retinal UniMod-description Retinylidene PSI-MS-label DiffAvg 266.43 DiffFormula C 20 H 26 N 0 O 0 DiffMono 266.203451 Formula C 26 H 38 N 2 O 1 MassAvg 394.60 MassMono 394.298414 Origin K Source natural TermSpec none MOD:00912 PSI-MOD MOD:00130 L-allysine A protein modification that effectively converts an L-lysine residue to L-allysine. 17917 ChEBI 0 DeltaMass 11120890 PubMed 11332453 PubMed 358196 PubMed 5337886 PubMed 5529814 PubMed AA0121 RESID 352#K UniMod From DeltaMass: Average Mass: -1 PSI-MOD-slim (2S)-2-amino-6-oxohexanoic acid RESID-systematic 2-amino-5-formylvaleric acid RESID-alternate 2-amino-adipic acid semialdahyde RESID-alternate 2-aminoadipate 6-semialdehyde RESID-alternate 5-formyl-norvaline RESID-alternate 6-oxonorleucine RESID-alternate AASA RESID-alternate Allysine (from Lysine) DeltaMass-label alpha-amino-adipic acid delta-semialdahyde RESID-alternate L-allysine RESID-name Lys->Allysine PSI-MS-label Lysal PSI-MOD-label Lysine oxidation to aminoadipic semialdehyde UniMod-description MOD_RES Allysine UniProt-feature Oxidation of lysine (to aminoadipic semialdehyde) DeltaMass-label DiffAvg -1.03 DiffFormula C 0 H -3 N -1 O 1 DiffMono -1.031634 Formula C 6 H 9 N 1 O 2 MassAvg 127.14 MassMono 127.063329 Origin K Source natural TermSpec none MOD:00912 PSI-MOD MOD:00131 L-2-aminoadipic acid A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid. 353 DeltaMass 336041 PubMed 358196 PubMed 7419498 PubMed AA0122 RESID 381#K UniMod From DeltaMass: References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. [This has been observed as a natural modification, see RESID:AA0122. JSG] PSI-MOD-slim (2S)-2-aminohexanedioic acid RESID-systematic 2-amino-1,4-butanedicarboxylic acid RESID-alternate alpha-amino adipic acid UniMod-description L-2-aminoadipic acid RESID-name L-alpha-aminoadipic acid RESID-alternate Lys->AminoadipicAcid PSI-MS-label Lysoic PSI-MOD-label Oxidation of lysine (to aminoadipic acid) DeltaMass-label DiffAvg 14.97 DiffFormula C 0 H -3 N -1 O 2 DiffMono 14.963280 Formula C 6 H 9 N 1 O 3 MassAvg 143.14 MassMono 143.058243 Origin K Source natural TermSpec none MOD:00912 PSI-MOD MOD:00132 L-lysinoalanine (Lys-Ser) A protein modification that effectively crosslinks an L-serine residue and an L-lysine residue to release water and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid. 0 DeltaMass 2544544 PubMed AA0123#KSX RESID Cross-link 2. This entry is for the crosslink of peptidyl serine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34. (2R,9S)-lysinoalanine RESID-alternate (2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid RESID-systematic alaninolysine RESID-alternate CROSSLNK Lysinoalanine (Ser-Lys) UniProt-feature L-lysinoalanine RESID-name LAL RESID-alternate Lysinoalanine (from Cysteine) DeltaMass-label N-epsilon-(2-amino-2-carboxyethyl)-L-lysine RESID-alternate N6-(2-amino-2-carboxyethyl)-L-lysine RESID-alternate XLNK-N6Lys-3Dha(Ser) PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 9 H 15 N 3 O 2 MassAvg 197.24 MassMono 197.116427 Origin K, S Source natural TermSpec none MOD:00916 MOD:00954 MOD:01853 PSI-MOD MOD:00133 N6-(L-isoglutamyl)-L-lysine (Gln) A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoglutamyl)-L-lysine and the release of ammonia. 21863 ChEBI 0 DeltaMass 2461365 PubMed 5637041 PubMed 5656070 PubMed 8598899 PubMed AA0124#GLN RESID Cross-link 2. PSI-MOD-slim (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid RESID-systematic 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid RESID-alternate 5-glutamyl N6-lysine RESID-alternate CROSSLNK Isoglutamyl lysine isopeptide (Lys-Gln) UniProt-feature N alpha -(gamma-Glutamyl)-lysine DeltaMass-label N(epsilon)-(gamma-glutamyl)lysine RESID-alternate N6-(L-isoglutamyl)-L-lysine RESID-name XLNK-N6Lys-5Glu(Gln) PSI-MOD-label DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 11 H 17 N 3 O 3 MassAvg 239.27 MassMono 239.126991 Origin K, Q Source natural TermSpec none MOD:00907 MOD:00946 MOD:01630 PSI-MOD MOD:00134 N6-glycyl-L-lysine A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine. 21885 ChEBI AA0125 RESID Cross-link 2; this is the common crosslink structure formed by ubiquitin, SUMO, and similar proteins. PSI-MOD-slim (2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid RESID-systematic N6-(glycyl)-L-lysine RESID-name N6-glycyllysine RESID-alternate XLNK-N6Lys-1Gly PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 8 H 14 N 3 O 2 MassAvg 184.22 MassMono 184.108602 Origin G, K Source natural TermSpec C-term MOD:00688 MOD:00908 MOD:00954 MOD:01875 PSI-MOD MOD:00135 N-(L-isoaspartyl)-glycine (Asn) A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine and the release of ammonia. 21479 ChEBI 1826288 PubMed AA0126 RESID Cross-link 2. (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid RESID-systematic 2-amino-N4-(carboxymethyl)-butanediamic acid RESID-alternate CROSSLNK Isoaspartyl glycine isopeptide (Asn-Gly) UniProt-feature CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asn) UniProt-feature isoaspartyl glycine RESID-alternate N-(L-isoaspartyl)-glycine RESID-name N-beta-aspartylglycine RESID-alternate N4-(carboxymethyl)-asparagine RESID-alternate XLNK-4Asp-NGly(Asn) PSI-MOD-label DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 6 H 7 N 2 O 3 MassAvg 155.13 MassMono 155.045667 Origin G, N Source natural TermSpec N-term MOD:00903 MOD:00946 MOD:01928 PSI-MOD MOD:00136 pyruvic acid (Cys) A protein modification that effectively converts an L-cysteine residue to pyruvic acid. 10085076 PubMed 3042771 PubMed 8464063 PubMed AA0127#CYS RESID 382 UniMod PSI-MOD-slim 2-oxopropanoic acid RESID-systematic MOD_RES Pyruvic acid (Cys) UniProt-feature Pyruv(Cys) PSI-MOD-label pyruvic acid RESID-name DiffAvg -33.09 DiffFormula C 0 H -3 N -1 O 1 S -1 DiffMono -33.003705 Formula C 3 H 3 O 2 MassAvg 71.06 MassMono 71.013304 Origin C Source natural TermSpec N-term MOD:00905 MOD:01154 PSI-MOD MOD:00137 L-3-phenyllactic acid A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid. 1973541 PubMed AA0128 RESID 7#F UniMod This modification is not the result of deamidation, instead the alpha amino group is replaced with an hydroxyl group. (2S)-2-hydroxy-3-phenylpropanoic acid RESID-systematic Deamidated UniMod-interim Deamidation UniMod-description L-3-phenyllactic acid RESID-name MOD_RES 3-phenyllactic acid UniProt-feature DiffAvg 0.98 DiffFormula C 0 H -1 N -1 O 1 DiffMono 0.984016 Formula C 9 H 9 O 2 MassAvg 149.17 MassMono 149.060255 Origin F TermSpec N-term MOD:00914 PSI-MOD MOD:00138 2-oxobutanoic acid A protein modification that effectively converts an L-threonine residue into 2-oxobutanoic acid. 15023056 PubMed 1680314 PubMed 2253617 PubMed 2764678 PubMed AA0129 RESID 385#T UniMod 2-ketobutyric acid RESID-alternate 2-oxobutanoic acid RESID-name 2-oxobutanoic acid RESID-systematic 2-oxobutyric acid RESID-alternate Ammonia-loss UniMod-interim Loss of ammonia UniMod-description MOD_RES 2-oxobutanoic acid UniProt-feature DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 4 H 5 O 2 MassAvg 85.08 MassMono 85.028954 Origin T TermSpec N-term MOD:00917 MOD:01160 PSI-MOD MOD:00139 N2-succinyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan. 11857757 PubMed 12175151 PubMed 8471040 PubMed AA0130 RESID 64#N-term UniMod (2S)-2-(3-carboxypropanoyl)amino-3-(1H-indol-3-yl)propanoic acid RESID-systematic (2S)-2-amino-(6,7-dihydro-6,7-dioxo-1H-indole)-3-propanoic acid RESID-alternate MOD_RES N2-succinyltryptophan UniProt-feature N2-succinyl-L-tryptophan RESID-name Succinic anhydride labeling reagent light form (N-term) UniMod-description Succinyl PSI-MS-label DiffAvg 100.07 DiffFormula C 4 H 4 N 0 O 3 DiffMono 100.016044 Formula C 15 H 15 N 2 O 4 MassAvg 287.29 MassMono 287.103182 Origin W TermSpec N-term MOD:00457 MOD:00918 PSI-MOD MOD:00140 S-phycocyanobilin-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycocyanobilin. 15617 ChEBI 0 DeltaMass 16644722 PubMed 3208761 PubMed 3838747 PubMed 7918400 PubMed AA0131 RESID 387#C UniMod From DeltaMass: Average Mass: 587. (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-ethyl-1,2,3,19,21,22,24-heptahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid RESID-alternate (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione RESID-systematic BINDING Phycocyanobilin chromophore (covalent; via 1 link) UniProt-feature PCB RESID-alternate phycobilin cysteine RESID-alternate Phycocyanobilin PSI-MS-label phycocyanobilin UniMod-description phycocyanobilin cysteine adduct RESID-alternate S-Phycocyanobilin (on Cysteine) DeltaMass-label S-phycocyanobilin-L-cysteine RESID-name DiffAvg 586.69 DiffFormula C 33 H 38 N 4 O 6 S 0 DiffMono 586.279135 Formula C 36 H 43 N 5 O 7 S 1 MassAvg 689.83 MassMono 689.288320 Origin C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00141 S-phycoerythrobilin-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoerythrobilin. 15618 ChEBI 14588022 PubMed 3208761 PubMed 3838747 PubMed 8876649 PubMed AA0132 RESID 388#C UniMod (2S,3R,16R)-18-ethenyl-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione RESID-systematic 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid RESID-alternate BINDING Phycoerythrobilin chromophore (covalent; via 1 link) UniProt-feature PEB RESID-alternate Phycoerythrobilin PSI-MS-label phycoerythrobilin UniMod-description phycoerythrobilin cysteine adduct RESID-alternate S-phycoerythrobilin-L-cysteine RESID-name DiffAvg 588.70 DiffFormula C 33 H 40 N 4 O 6 S 0 DiffMono 588.294785 Formula C 36 H 45 N 5 O 7 S 1 MassAvg 691.84 MassMono 691.303970 Origin C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00142 S-phytochromobilin-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phytochromobilin. 15619 ChEBI 1634523 PubMed 16593380 PubMed 3208761 PubMed 7918400 PubMed AA0133 RESID 389#C UniMod (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione RESID-systematic 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid RESID-alternate BINDING Phytochromobilin chromophore (covalent; via 1 link) UniProt-feature phytochrome chromophore RESID-alternate Phytochromobilin PSI-MS-label phytochromobilin UniMod-description phytochromobilin cysteine adduct RESID-alternate S-phytochromobilin-L-cysteine RESID-name DiffAvg 584.67 DiffFormula C 33 H 36 N 4 O 6 S 0 DiffMono 584.263485 Formula C 36 H 41 N 5 O 7 S 1 MassAvg 687.81 MassMono 687.272670 Origin C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00143 heme-bis-L-cysteine A protein modification that effectively results from forming an adduct between two cysteine residues and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 17627 ChEBI 5545094 PubMed 8827449 PubMed AA0134 RESID Cross-link 2. PSI-MOD-slim (7,12-bis[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate RESID-systematic 2,4-bis[1-(S-cysteinyl)ethyl]protoporphyrin IX RESID-alternate BINDING Heme (covalent) UniProt-feature biscysteinyl heme RESID-alternate heme-bis-L-cysteine RESID-name HemeCys2 PSI-MOD-label DiffAvg 616.50 DiffFormula C 34 Fe 1 H 32 N 4 O 4 S 0 DiffMono 616.177293 Formula C 40 Fe 1 H 42 N 6 O 6 S 2 MassAvg 822.78 MassMono 822.195663 Origin C, C Source natural TermSpec none MOD:00699 MOD:00905 PSI-MOD MOD:00144 heme-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 17627 ChEBI 0 DeltaMass 170910 PubMed 192772 PubMed 2536325 PubMed 9535866 PubMed AA0135 RESID 390#C UniMod From DeltaMass: Average Mass: 617. PSI-MOD-slim (12-ethenyl-7-[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate RESID-systematic 4-[1-(S-cysteinyl)ethyl]protoporphyrin IX RESID-alternate BINDING Heme (covalent; via 1 link) UniProt-feature cysteinyl heme RESID-alternate Heme PSI-MS-label heme UniMod-description heme-L-cysteine RESID-name HemeCys1 PSI-MOD-label S-Heme (on Cysteine) DeltaMass-label DiffAvg 616.50 DiffFormula C 34 Fe 1 H 32 N 4 O 4 S 0 DiffMono 616.177293 Formula C 37 Fe 1 H 37 N 5 O 5 S 1 MassAvg 719.64 MassMono 719.186478 Origin C Source natural TermSpec none MOD:00699 MOD:00905 PSI-MOD MOD:00145 tetrakis-L-cysteinyl iron A protein modification that effectively converts four L-cysteine residues iron atom to tetrakis-L-cysteinyl iron. 1303768 PubMed 2244884 PubMed AA0136 RESID Cross-link 4. METAL Iron UniProt-feature tetrakis(cysteinato-kappaS)-iron RESID-systematic tetrakis-L-cysteinyl iron RESID-name DiffAvg 51.81 DiffFormula C 0 Fe 1 H -4 N 0 O 0 S 0 DiffMono 51.904735 FormalCharge 2- Formula C 12 Fe 1 H 16 N 4 O 4 S 4 MassAvg 464.37 MassMono 463.941474 Origin C, C, C, C Source natural TermSpec none MOD:00738 MOD:00905 PSI-MOD MOD:00146 tetrakis-L-cysteinyl diiron disulfide A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to tetrakis-L-cysteinyl diiron disulfide. 2123937 PubMed 6801028 PubMed 7763242 PubMed 8688437 PubMed AA0137 RESID Cross-link 4. METAL Iron-sulfur (2Fe-2S) UniProt-feature METAL Iron-sulfur (2Fe-2S); shared with dimeric partner UniProt-feature tetrakis-L-cysteinyl diiron disulfide RESID-name tetrakiscysteinato-1kappa(2)S,2kappa(2)S-di-mu-sulfido-diiron RESID-systematic DiffAvg 171.78 DiffFormula C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono 171.783814 FormalCharge 2- Formula C 12 Fe 2 H 16 N 4 O 4 S 6 MassAvg 584.34 MassMono 583.820553 Origin C, C, C, C Source natural TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00147 hexakis-L-cysteinyl triiron trisulfide A protein modification that effectively converts six L-cysteine residues and a three-iron three-sulfur cluster to hexakis-L-cysteinyl triiron trisulfide. 3379067 PubMed 3932661 PubMed 7354058 PubMed AA0138 RESID Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. hexakis-L-cysteinyl triiron trisulfide RESID-name tri-mu-sulfido-hexakiscysteinato-1kappa(2)S,2kappa(2)S,3kappa(2)S-triiron RESID-systematic tri-mu-sulfidotris(biscysteinato-kappaS-iron) RESID-alternate DiffAvg 257.67 DiffFormula C 0 Fe 3 H -6 N 0 O 0 S 3 DiffMono 257.675721 FormalCharge 3- Formula C 18 Fe 3 H 24 N 6 O 6 S 9 MassAvg 876.50 MassMono 875.730830 Origin C, C, C, C, C, C Source hypothetical TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00148 tris-L-cysteinyl triiron tetrasulfide A protein modification that effectively converts three L-cysteine residues and a three-iron four-sulfur cluster to tris-L-cysteinyl triiron tetrasulfide. 10555576 PubMed 2056535 PubMed 3422475 PubMed 6848518 PubMed 7819255 PubMed 9063899 PubMed AA0139 RESID Cross-link 3. METAL Iron-sulfur (3Fe-4S) UniProt-feature mu3-sulfido tri-mu-sulfido tris-S-L-cysteinyl triiron RESID-alternate mu3-sulfido-tri-mu-sulfido-triscysteinato-1kappaS,2kappaS,3kappaS-triiron RESID-systematic tris-L-cysteinyl triiron tetrasulfide RESID-name tris-L-cysteinyl triiron tetrasulfide C3 cluster RESID-alternate tris-L-cysteinyl triiron tetrasulfide cubane form RESID-alternate tris-L-cysteinyl triiron tetrasulfide cuboid cluster RESID-alternate tris-L-cysteinyl triiron tetrasulfide trigonal cluster RESID-alternate DiffAvg 292.75 DiffFormula C 0 Fe 3 H -3 N 0 O 0 S 4 DiffMono 292.671267 FormalCharge 3- Formula C 9 Fe 3 H 12 N 3 O 3 S 7 MassAvg 602.17 MassMono 601.698821 Origin C, C, C Source natural TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00149 tetrakis-L-cysteinyl tetrairon tetrasulfide A protein modification that effectively converts four L-cysteine residues and a four-iron four-sulfur cluster to tetrakis-L-cysteinyl tetrairon tetrasulfide. 3351918 PubMed 7803404 PubMed 7819196 PubMed 932007 PubMed AA0140 RESID Cross-link 4. METAL Iron-sulfur (4Fe-4S) UniProt-feature METAL Iron-sulfur (4Fe-4S); shared with dimeric partner UniProt-feature tetra-mu3-sulfido-tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-tetrahedro-tetrairon RESID-systematic tetra-mu3-sulfidotetrakis(S-cysteinyliron) RESID-alternate tetrakis-L-cysteinyl tetrairon tetrasulfide RESID-name DiffAvg 347.59 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.597831 FormalCharge 2- Formula C 12 Fe 4 H 16 N 4 O 4 S 8 MassAvg 760.15 MassMono 759.634570 Origin C, C, C, C Source natural TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00150 L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-molybdenum seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide. 10525412 PubMed 12215645 PubMed 12733878 PubMed 1529354 PubMed 8027059 PubMed AA0141 RESID Cross-link 2; incidental to RESID:AA0300. cysteinato-8kappaS-histidino-1kappaN(tau)-[(2R)-4-carboxy-2-(carboxymethyl)-2-oxidobutanoate-1kappaO(1),1kappaO(2)]-mu6-carbido-2:3:4:5:6:7kappa(6)C-hexa-mu3-sulfido-1:2:3kappa(3)S;1:2:4kappa(3)S;1:3:4kappa(3)S;5:6:8kappa(3)S;5:7:8kappa(3)S;6:7:8kappa(3)S-tri-mu2-sulfido-2:5kappa(2)S;3:6kappa(2)S;4:7kappa(2)S molybdenum heptairon RESID-systematic L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide carbide RESID-name nitrogenase iron-molybdenum cofactor RESID-alternate DiffAvg 991.53 DiffFormula C 7 Fe 7 H 6 Mo 1 N 1 O 7 S 9 DiffMono 993.213036 Formula C 16 Fe 7 H 18 Mo 1 N 5 O 9 S 10 MassAvg 1231.81 MassMono 1233.281133 Origin C, H Source natural TermSpec none MOD:00739 MOD:00743 MOD:00905 MOD:00909 PSI-MOD MOD:00151 L-cysteinyl molybdopterin A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdopterin. 14527393 PubMed 7878465 PubMed 9428520 PubMed AA0142 RESID 391#C UniMod PSI-MOD-slim (4R,5aR,11aR)-8-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-4,5a,6,9,10,11,11a-heptahydro-4-(phosphoric acid)methyl-2,2,10-trioxo-pteridino[6,7-5,6]pyrano[3,4-4,3][1,2,5]molybdadithiolene RESID-systematic cysteinyl Mo-molybdopterin RESID-alternate cysteinyl Mo-pterin RESID-alternate L-cysteinyl molybdopterin RESID-name METAL Molybdenum-pterin UniProt-feature molybdoenzyme molybdenum cofactor RESID-alternate Molybdopterin PSI-MS-label molybdopterin UniMod-description MoPterCys PSI-MOD-label DiffAvg 520.27 DiffFormula C 10 H 11 Mo 1 N 5 O 8 P 1 S 2 DiffMono 521.884074 Formula C 13 H 16 Mo 1 N 6 O 9 P 1 S 3 MassAvg 623.41 MassMono 624.893259 Origin C Source natural TermSpec none MOD:00744 MOD:00861 MOD:00905 PSI-MOD MOD:00152 S-(8alpha-FAD)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S'-(8alpha-FAD)-L-cystine. 10220347 PubMed AA0143 RESID 50#C UniMod PSI-MOD-slim (2R)-2-amino-3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]sulfanylpropanoic acid RESID-systematic 8alpha-(S-cysteinyl)FAD RESID-alternate FAD PSI-MS-label Flavin adenine dinucleotide UniMod-description MOD_RES S-8alpha-FAD cysteine UniProt-feature S-(8alpha-FAD)-L-cysteine RESID-name S8aFADCys PSI-MOD-label DiffAvg 783.54 DiffFormula C 27 H 31 N 9 O 15 P 2 S 0 DiffMono 783.141485 Formula C 30 H 36 N 10 O 16 P 2 S 1 MassAvg 886.68 MassMono 886.150669 Origin C Source natural TermSpec none MOD:00895 MOD:00905 PSI-MOD MOD:00153 3'-(8alpha-FAD)-L-histidine A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FAD)-L-histidine. 241294 PubMed 8076 PubMed AA0144 RESID 50#H UniMod PSI-MOD-slim (2S)-2-amino-3-(3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid RESID-systematic 3'-(8alpha-FAD)-L-histidine RESID-name 8alpha-(N(delta)-histidyl)FAD RESID-alternate 8alpha-(N3'-histidyl)FAD RESID-alternate 8alpha-N1-histidyl FAD RESID-misnomer FAD PSI-MS-label Flavin adenine dinucleotide UniMod-description MOD_RES Pros-8alpha-FAD histidine UniProt-feature N(pi)-(8alpha-FAD)-histidine RESID-alternate Np8aFADHis PSI-MOD-label pros-(8alpha-FAD)-histidine RESID-alternate DiffAvg 783.54 DiffFormula C 27 H 31 N 9 O 15 P 2 DiffMono 783.141485 Formula C 33 H 38 N 12 O 16 P 2 MassAvg 920.68 MassMono 920.200396 Origin H Source natural TermSpec none MOD:00895 MOD:00909 PSI-MOD MOD:00154 O4'-(8alpha-FAD)-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-(8alpha-FAD)-L-tyrosine. 0 DeltaMass 7391034 PubMed AA0145 RESID 50#Y UniMod From DeltaMass: Average Mass: 783 PSI-MOD-slim (2S)-2-amino-3-(4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxyphenyl)propanoic acid RESID-systematic 8alpha-(O4'-tyrosyl)FAD RESID-alternate FAD PSI-MS-label Flavin adenine dinucleotide UniMod-description MOD_RES O-8alpha-FAD tyrosine UniProt-feature O-8 alpha-Flavin [FAD])- (of Tyrosine) DeltaMass-label O4'-(8alpha-FAD)-L-tyrosine RESID-name O8aFADTyr PSI-MOD-label DiffAvg 783.54 DiffFormula C 27 H 31 N 9 O 15 P 2 DiffMono 783.141485 Formula C 36 H 40 N 10 O 17 P 2 MassAvg 946.72 MassMono 946.204813 Origin Y Source natural TermSpec none MOD:00895 MOD:00919 PSI-MOD MOD:00155 3'-hydroxylation of L-tyrosine to L-3',4'-dihydroxyphenylalanine A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine. 0 DeltaMass 1610822 PubMed 1903612 PubMed 3734192 PubMed AA0146 RESID 35#Y UniMod incidental to RESID:AA0368 From DeltaMass: Average Mass: 16 PSI-MOD-slim (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid RESID-systematic 3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA) DeltaMass-label 3HyTyr PSI-MOD-label hydroxylationy OMSSA-label L-3',4'-dihydroxyphenylalanine RESID-name L-3'-hydroxytyrosine RESID-alternate L-DOPA RESID-alternate levodopa RESID-alternate mod194 OMSSA-label MOD_RES 3',4'-dihydroxyphenylalanine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 9 H 9 N 1 O 3 MassAvg 179.18 MassMono 179.058243 Origin Y Source natural TermSpec none MOD:00425 MOD:00707 PSI-MOD MOD:00156 oxidation of tyrosine to L-2',4',5'-topaquinone A protein modification that effectively converts an L-tyrosine residue to an L-2',4',5'-topaquinone. 21187 ChEBI 10387067 PubMed 1457410 PubMed 1569055 PubMed 2111581 PubMed AA0147 RESID 392#Y UniMod PSI-MOD-slim (2S)-2-amino-3-(5-hydroxy-2,5-cyclohexadien-1,4-dion-2-yl)propanoic acid RESID-systematic 2,4,5-trihydroxyphenylalanine quinone RESID-alternate 5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone RESID-alternate L-2',4',5'-topaquinone RESID-name L-2,4,5-TOPAquinone RESID-alternate MOD_RES 2',4',5'-topaquinone UniProt-feature Quinone PSI-MS-label quinone UniMod-description TopaQ PSI-MOD-label TPQ RESID-alternate DiffAvg 29.98 DiffFormula C 0 H -2 N 0 O 2 DiffMono 29.974179 Formula C 9 H 7 N 1 O 4 MassAvg 193.16 MassMono 193.037508 Origin Y Source natural TermSpec none MOD:00679 MOD:00919 PSI-MOD MOD:00157 oxidation of tryptophan to L-tryptophyl quinone A protein modification that effectively converts an L-tryptophan residue to an L-tryptophan quinone. 0 DeltaMass 2028257 PubMed AA0148 RESID 392#W UniMod incidental to RESID:AA0149; incidental to RESID:AA0313; From DeltaMass: Average Mass: 30. PSI-MOD-slim (2S)-2-amino-3-(6,7-dioxo-1H-indol-3-yl)propanoic acid RESID-systematic 2-amino-3-(6,7-dioxo-6,7-dihydro-1H-indol-3-yl)-propionic acid RESID-alternate 3-[(2S)-2-amino-2-carboxyethyl]-6,7-indolinedione RESID-alternate 6,7 Dione (from Tryptophan) DeltaMass-label L-tryptophyl quinone RESID-name MOD_RES Tryptophylquinone UniProt-feature N-(3-carboxy-1-oxopropyl)-L-tryptophan RESID-alternate Quinone PSI-MS-label quinone UniMod-description TrpQ PSI-MOD-label DiffAvg 29.98 DiffFormula C 0 H -2 N 0 O 2 DiffMono 29.974179 Formula C 11 H 8 N 2 O 3 MassAvg 216.20 MassMono 216.053492 Origin W Source natural TermSpec none MOD:00679 MOD:00918 PSI-MOD MOD:00158 4'-(L-tryptophan)-L-tryptophyl quinone A protein modification that effectively cross-links two L-tryptophan residues by a carbon-carbon bond to form 4'-(L-tryptophan)-L-tryptophyl quinone. 20251 ChEBI 0 DeltaMass 2028257 PubMed AA0149 RESID Cross-link 2; secondary to RESID:AA0148; From DeltaMass: Average Mass: 28. PSI-MOD-slim 2,4-BisTrp-6,7-dione (from Tryptophan) DeltaMass-label 2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid RESID-alternate 3-[(2S)-2-amino-2-carboxyethyl]-4-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-6,7-indolinedione RESID-systematic 4'-tryptophan-tryptophylquinone RESID-alternate 4-(2'-tryptophyl)tryptophan-6,7-dione RESID-alternate 4-(L-tryptophan-2-yl)-L-tryptophyl quinone RESID-name alpha,alpha'-diamino-6',7'-dihydro-6',7'-dioxo-(2,4'-bi-1H-indole)-3,3'-dipropanoic acid RESID-alternate CROSSLNK Tryptophan tryptophylquinone (Trp-Trp) UniProt-feature TTQ RESID-alternate XLNK-4'Trp-TrpQ PSI-MOD-label DiffAvg 27.97 DiffFormula C 0 H -4 N 0 O 2 DiffMono 27.958529 Formula C 22 H 16 N 4 O 4 MassAvg 400.39 MassMono 400.117155 Origin W, W Source natural TermSpec none MOD:00692 MOD:00918 PSI-MOD MOD:00159 O-phosphopantetheine-L-serine A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine. 0 DeltaMass 10320345 PubMed 10997907 PubMed 12057197 PubMed 12869567 PubMed 4568609 PubMed AA0150 RESID 49#S UniMod UniMod has DiffFormula C 11 H 20 N 2 O 6 P 1 S 1 From DeltaMass: Average Mass: 339 PSI-MOD-slim (2R)-2-hydroxy-3,3-dimethyl-4-[(2S)-2-amino-2-carboxyethyl]phosphonato-N-(3-oxo-3-[(2-sulfanylethyl)amino]propyl)butanamide RESID-systematic 4'-Phosphopantetheine DeltaMass-label MOD_RES O-(pantetheine 4'-phosphoryl)serine UniProt-feature O-phosphopantetheine-L-serine RESID-name OPpantSer PSI-MOD-label Phosphopantetheine PSI-MS-label Phosphopantetheine UniMod-description DiffAvg 340.33 DiffFormula C 11 H 21 N 2 O 6 P 1 S 1 DiffMono 340.085794 Formula C 14 H 26 N 3 O 8 P 1 S 1 MassAvg 427.41 MassMono 427.117822 Origin S Source natural TermSpec none MOD:00861 MOD:00916 PSI-MOD MOD:00160 N4-glycosyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine. 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID PSI-MOD-slim N4GlycoAsn PSI-MOD-label Origin N Source natural TermSpec none MOD:00006 MOD:00903 PSI-MOD MOD:00161 S-glucosyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine. 1145128 PubMed 15279557 PubMed 5286858 PubMed AA0152 RESID 41#C UniMod (2R)-2-amino-3-[(beta-D-glucopyranosyl)sulfanyl]propanoic acid RESID-systematic CARBOHYD S-linked (Glc) UniProt-feature Hex PSI-MS-label Hexose UniMod-description S-(beta-D-glucopyranosyl)cysteine RESID-alternate S-glucosyl-L-cysteine RESID-name S-glycosyl-cysteine RESID-alternate SGlcCys PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 S 0 DiffMono 162.052823 Formula C 9 H 15 N 1 O 6 S 1 MassAvg 265.28 MassMono 265.062008 Origin C Source natural TermSpec none MOD:00426 MOD:00433 MOD:00761 MOD:00905 PSI-MOD MOD:00162 O5-glucosylgalactosyl-L-hydroxylysine A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine. 15149698 PubMed 4288358 PubMed 4319110 PubMed AA0153 RESID 393 UniMod Secondary to RESID:AA0028. PSI-MOD-slim (2S,5R)-2,6-diamino-5-[2-O-(alpha-D-glucopyranosyl)-beta-D-galactopyranosyloxy]hexanoic acid RESID-systematic 5-(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy-L-lysine RESID-alternate Glucosylgalactosyl PSI-MS-label glucosylgalactosyl hydroxylysine UniMod-description O5-glucosylgalactosyl-L-hydroxylysine RESID-name OGlcGal5HyLys PSI-MOD-label DiffAvg 340.28 DiffFormula C 12 H 20 N 0 O 11 DiffMono 340.100561 Formula C 18 H 32 N 2 O 12 MassAvg 468.46 MassMono 468.195524 Origin K Source natural TermSpec none MOD:00037 MOD:00396 MOD:00476 MOD:00726 PSI-MOD MOD:00163 O-(N-acetylamino)galactosyl-L-serine A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine. 115869 PubMed 16005634 PubMed 3086323 PubMed 8948436 PubMed 9092502 PubMed AA0154 RESID PSI-MOD-slim (2S)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)propanoic acid RESID-systematic CARBOHYD O-linked (GalNAc) UniProt-feature HexNAc PSI-MS-label mucin type O-glycosylserine RESID-alternate O-(N-acetylamino)galactosyl-L-serine RESID-name O3-(N-acetylgalactosaminyl)serine RESID-alternate OGalNAcSer PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 11 H 18 N 2 O 7 MassAvg 290.27 MassMono 290.111401 Origin S Source natural TermSpec none MOD:00563 MOD:01675 PSI-MOD MOD:00164 O-(N-acetylamino)galactosyl-L-threonine A protein modification that effectively converts an L-asparagine residue to O-(N-acetylaminogalactosyl)-L-threonine. 16005634 PubMed 1997327 PubMed 3086323 PubMed 8948436 PubMed 9092502 PubMed AA0155 RESID PSI-MOD-slim (2S,3R)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)butanoic acid RESID-systematic CARBOHYD O-linked (GalNAc) UniProt-feature CARBOHYD O-linked (HexNAc) UniProt-feature HexNAc PSI-MS-label mucin type O-glycosylthreonine RESID-alternate O-(N-acetylamino)galactosyl-L-threonine RESID-name O3-(N-acetylgalactosaminyl)threonine RESID-alternate OGalNAcThr PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 12 H 20 N 2 O 7 MassAvg 304.30 MassMono 304.127051 Origin T Source natural TermSpec none MOD:00563 MOD:01676 PSI-MOD MOD:00165 1'-mannosyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan. 1482345 PubMed 16150691 PubMed AA0156 RESID PSI-MOD-slim (2S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid RESID-systematic 1'-glycosyl-L-tryptophan RESID-alternate 1'-mannosyl-L-tryptophan RESID-name CARBOHYD N-linked (Man) UniProt-feature N-mannosyl-tryptophan RESID-alternate N1'ManTrp PSI-MOD-label N1-mannosyl-tryptophan RESID-alternate DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 17 H 20 N 2 O 6 MassAvg 348.36 MassMono 348.132136 Origin W Source natural TermSpec none MOD:00006 MOD:00595 MOD:00761 MOD:00918 PSI-MOD MOD:00166 O4'-glucosyl-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-glucosyl-tyrosine. 15279557 PubMed 3181138 PubMed AA0157 RESID 41#Y UniMod (2S)-2-amino-3-(4-alpha-D-glucopyranosyloxy)phenylpropanoic acid RESID-systematic Hex PSI-MS-label Hexose UniMod-description O4'-glucosyl-L-tyrosine RESID-name O4'-glycosyl-L-tyrosine RESID-alternate O4GlcTyr PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 15 H 19 N 1 O 7 MassAvg 325.32 MassMono 325.116152 Origin Y Source natural TermSpec none MOD:00433 MOD:00761 MOD:01927 PSI-MOD MOD:00167 N-asparaginyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine. 1824714 PubMed 8276756 PubMed AA0158 RESID GPIAsn PSI-MOD-label LIPID GPI-anchor amidated asparagine UniProt-feature N-asparaginyl-glycosylphosphatidylinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 6 H 13 N 3 O 6 P 1 MassAvg 254.16 MassMono 254.054197 Origin N Source natural TermSpec C-term MOD:00818 MOD:00903 PSI-MOD MOD:00168 N-aspartyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-aspartic acid residue to N-(aspart-1-yl)-glycosylphosphatidylinositolethanolamine. 7120400 PubMed AA0159 RESID GPIAsp PSI-MOD-label LIPID GPI-anchor amidated aspartate UniProt-feature N-aspartyl-glycosylphosphatidylinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 6 H 12 N 2 O 7 P 1 MassAvg 255.14 MassMono 255.038212 Origin D Source natural TermSpec C-term MOD:00818 MOD:00904 PSI-MOD MOD:00169 N-cysteinyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-cysteine residue to N-cysteinyl-glycosylphosphatidylinositolethanolamine. 2897081 PubMed AA0160 RESID GPICys PSI-MOD-label LIPID GPI-anchor amidated cysteine UniProt-feature N-cysteinyl-glycosylphosphatidylinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 S 0 DiffMono 123.008530 Formula C 5 H 12 N 2 O 5 P 1 S 1 MassAvg 243.19 MassMono 243.020454 Origin C Source natural TermSpec C-term MOD:00818 MOD:00905 PSI-MOD MOD:00170 N-glycyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine. 2341397 PubMed AA0161 RESID GPIGly PSI-MOD-label LIPID GPI-anchor amidated glycine UniProt-feature N-glycyl-glycosylphosphatidylinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 4 H 10 N 2 O 5 P 1 MassAvg 197.11 MassMono 197.032733 Origin G Source natural TermSpec C-term MOD:00818 MOD:00908 PSI-MOD MOD:00171 N-seryl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine. 2111324 PubMed 8448158 PubMed AA0162 RESID GPISer PSI-MOD-label LIPID GPI-anchor amidated serine UniProt-feature N-seryl-glycosylphosphatidylinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 5 H 12 N 2 O 6 P 1 MassAvg 227.13 MassMono 227.043298 Origin S Source natural TermSpec C-term MOD:00818 MOD:00916 PSI-MOD MOD:00172 N-alanyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine. 7682556 PubMed 7744038 PubMed AA0163 RESID GPIAla PSI-MOD-label LIPID GPI-anchor amidated alanine UniProt-feature N-alanyl-glycosylphosphatidylinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 5 H 12 N 2 O 5 P 1 MassAvg 211.13 MassMono 211.048383 Origin A Source natural TermSpec C-term MOD:00818 MOD:00901 PSI-MOD MOD:00173 N-threonyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-threonine residue to N-threonyl-glycosylphosphatidylinositolethanolamine. AA0164 RESID GPIThr PSI-MOD-label LIPID GPI-anchor amidated threonine UniProt-feature N-threonyl-glycosylphosphatidylinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 6 H 14 N 2 O 6 P 1 MassAvg 241.16 MassMono 241.058948 Origin T Source hypothetical TermSpec C-term MOD:00818 MOD:00917 PSI-MOD MOD:00174 N-glycyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine. 12626404 PubMed 8404891 PubMed AA0165 RESID GSIGly PSI-MOD-label LIPID GPI-like-anchor amidated glycine UniProt-feature N-glycyl-glycosylsphingolipidinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 4 H 10 N 2 O 5 P 1 MassAvg 197.11 MassMono 197.032733 Origin G Source hypothetical TermSpec C-term MOD:00466 MOD:00908 PSI-MOD MOD:00175 N-seryl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-serine residue to N-seryl-glycosylsphingolipidinositolethanolamine. 12626404 PubMed 2721485 PubMed 8269952 PubMed AA0166 RESID GSISer PSI-MOD-label LIPID GPI-like-anchor amidated serine UniProt-feature N-seryl-glycosylsphingolipidinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 5 H 12 N 2 O 6 P 1 MassAvg 227.13 MassMono 227.043298 Origin S Source natural TermSpec C-term MOD:00466 MOD:00916 PSI-MOD MOD:00176 O-(phosphoribosyl dephospho-coenzyme A)-L-serine A protein modification that effectively converts an L-serine residue to O-(phosphoribosyl dephospho-coenzyme A)-L-serine. 10924139 PubMed 11052675 PubMed 179809 PubMed 180526 PubMed 368065 PubMed AA0167 RESID 395#S UniMod pRibodePcoA PSI-MOD-slim MOD_RES O-(phosphoribosyl dephospho-coenzyme A)serine UniProt-feature O-(phosphoribosyl dephospho-coenzyme A)-L-serine RESID-name O3-(phosphate-5-ribosyl-alpha-2-adenosine-5-diphosphate pantetheine)-L-serine RESID-alternate O3-(phosphoribosyl dephospho-coenzyme A)-L-serine RESID-alternate O3-2'-(5''-phosphoribosyl-3'-dephosphocoenzyme A)-L-serine RESID-alternate OPRibdPCoASer PSI-MOD-label phosphoribosyl dephospho-coenzyme A UniMod-description PhosphoribosyldephosphoCoA PSI-MS-label DiffAvg 881.63 DiffFormula C 26 H 42 N 7 O 19 P 3 S 1 DiffMono 881.146903 Formula C 29 H 47 N 8 O 21 P 3 S 1 MassAvg 968.71 MassMono 968.178931 Origin S Source natural TermSpec none MOD:00860 MOD:00861 MOD:00916 PSI-MOD MOD:00177 omega-N-(ADP-ribosyl)-L-arginine A protein modification that effectively converts an L-argininine residue to omega-N-(ADP-ribosyl)-L-arginine. 0 DeltaMass 15842200 PubMed 209022 PubMed 3090031 PubMed 3923473 PubMed 6582062 PubMed AA0168 RESID 213#R UniMod From DeltaMass: Average Mass: 541. PSI-MOD-slim (S)-2-amino-5-([imino([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)methyl]amino)pentanoic acid RESID-systematic ADP Ribose addition UniMod-description ADP-Ribosyl PSI-MS-label ADPRibArg PSI-MOD-label MOD_RES ADP-ribosylarginine UniProt-feature N(omega)-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-arginine RESID-alternate N(omega)-alpha-D-ribofuranosyl-L-arginine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) RESID-alternate N-(ADP-ribosyl)- (on Arginine) DeltaMass-label omega-N-(ADP-ribosyl)-L-arginine RESID-name DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 21 H 33 N 9 O 14 P 2 MassAvg 697.49 MassMono 697.162220 Origin R Source natural TermSpec none MOD:00752 MOD:00902 PSI-MOD MOD:00178 S-(ADP-ribosyl)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(ADP-ribosyl)-L-cysteine. 0 DeltaMass 15842200 PubMed 3863818 PubMed AA0169 RESID 213#C UniMod From DeltaMass: Average Mass: 541. PSI-MOD-slim (R)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]sulfanyl)propanoic acid RESID-systematic ADP Ribose addition UniMod-description ADP-Ribosyl PSI-MS-label ADPRibCys PSI-MOD-label MOD_RES ADP-ribosylcysteine UniProt-feature S-(ADP-ribosyl)- (on Cysteine) DeltaMass-label S-(ADP-ribosyl)-L-cysteine RESID-name S-alpha-D-ribofuranosyl-L-cysteine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) RESID-alternate S-L-cysteine alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) RESID-alternate DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 S 0 DiffMono 541.061109 Formula C 18 H 26 N 6 O 14 P 2 S 1 MassAvg 644.44 MassMono 644.070294 Origin C Source natural TermSpec none MOD:00752 MOD:00905 PSI-MOD MOD:00179 L-glutamyl 5-glycerylphosphorylethanolamine A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-glycerylphosphorylethanolamine. 2511205 PubMed 2569467 PubMed 9662537 PubMed AA0170 RESID 396#E UniMod glycerylPE PSI-MOD-slim (S)-2-amino-5-[2-([([2,3-dihydroxypropyl]oxy)(hydroxy)phosphoryl]oxy)ethyl]amino-5-oxopentanoic acid RESID-systematic 5-L-glutamyl glycerylphosphorylethanolamine RESID-name 5GlyceroPEtAGlu PSI-MOD-label GlycerylPE PSI-MS-label glycerylphosphorylethanolamine UniMod-description L-glutamyl 5-glycerophosphoethanolamine RESID-alternate L-glutamyl 5-glycerophosphorylethanolamine RESID-alternate L-glutamyl 5-glycerylphosphorylethanolamine RESID-alternate MOD_RES 5-glutamyl glycerylphosphorylethanolamine UniProt-feature DiffAvg 197.13 DiffFormula C 5 H 12 N 1 O 5 P 1 DiffMono 197.045309 Formula C 10 H 19 N 2 O 8 P 1 MassAvg 326.24 MassMono 326.087902 Origin E Source natural TermSpec none MOD:00906 PSI-MOD MOD:00180 S-sulfo-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-sulfo-L-cysteine. 12876326 PubMed 14752058 PubMed 643076 PubMed AA0171 RESID 40#C UniMod (2R)-2-amino-3-(sulfosulfanyl)propanoic acid RESID-systematic 2-amino-3-(sulfothio)propanoic acid RESID-alternate 3-(sulfosulfanyl)-L-alanine RESID-alternate cysteine sulfate thioester RESID-alternate cysteine-S-sulfonic acid RESID-alternate O-Sulfonation UniMod-description S-sulfo-L-cysteine RESID-name S-sulfocysteine PSI-MOD-alternate S-sulfocysteine RESID-alternate SSulfCys PSI-MOD-label Sulfo PSI-MS-label DiffAvg 80.06 DiffFormula C 0 H 0 N 0 O 3 S 1 DiffMono 79.956815 Formula C 3 H 5 N 1 O 4 S 2 MassAvg 183.20 MassMono 182.966000 Origin C Source natural TermSpec none MOD:00695 MOD:00777 MOD:00905 PSI-MOD MOD:00181 O4'-sulfo-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-sulfo-L-tyrosine. 88 DeltaMass 10226369 PubMed 14752058 PubMed 2303439 PubMed 3778455 PubMed 3801003 PubMed AA0172 RESID 40#Y UniMod From DeltaMass: Average Mass: 80 Average Mass Change:80 PubMed:9624161. PSI-MOD-slim (S)-2-amino-3-(4-sulfooxyphenyl)propanoic acid RESID-systematic 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-sulfate RESID-alternate MOD_RES Sulfotyrosine UniProt-feature O-Sulfonation UniMod-description O4'-sulfo-L-tyrosine RESID-name O4-sulfotyrosine RESID-alternate OSulfTyr PSI-MOD-label sulfationy OMSSA-label Sulfo PSI-MS-label Sulphation (of O of Tyrosine) DeltaMass-label tyrosine sulfate RESID-alternate tyrosine-O-sulfonic acid RESID-alternate tyrosine-O-sulphonic acid RESID-alternate Tyrosinyl Sulphate DeltaMass-label DiffAvg 80.06 DiffFormula C 0 H 0 N 0 O 3 S 1 DiffMono 79.956815 Formula C 9 H 9 N 1 O 5 S 1 MassAvg 243.23 MassMono 243.020143 Origin Y Source natural TermSpec none MOD:00695 MOD:00774 MOD:00919 PSI-MOD MOD:00182 L-bromohistidine A protein modification that effectively converts an L-histidine residue to L-bromohistidine. 2076468 PubMed 9033387 PubMed AA0173 RESID 340#H UniMod Br1His PSI-MOD-label bromination UniMod-description Bromo PSI-MS-label L-bromohistidine RESID-name MOD_RES Bromohistidine UniProt-feature DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910512 Formula Br 1 C 6 H 6 N 3 O 1 MassAvg 216.04 MassMono 214.969424 Origin H Source natural TermSpec none MOD:01049 MOD:01912 PSI-MOD MOD:00183 L-2'-bromophenylalanine A protein modification that effectively converts an L-phenylalanine residue to L-2'-bromophenylalanine. 83 DeltaMass 2059627 PubMed 2076468 PubMed 9033387 PubMed AA0174 RESID From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa. (S)-2-amino-3-(2-bromophenyl)propanoic acid RESID-systematic 2'BrPhe PSI-MOD-label bromination UniMod-description Bromo PSI-MS-label L-2'-bromophenylalanine RESID-name L-o-bromination of Phe with 79Br DeltaMass-label o-bromophenylalanine RESID-alternate ortho-bromophenylalanine RESID-alternate DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910512 Formula Br 1 C 9 H 8 N 1 O 1 MassAvg 226.07 MassMono 224.978926 Origin F Source natural TermSpec none MOD:00972 PSI-MOD MOD:00184 L-3'-bromophenylalanine A protein modification that effectively converts an L-phenylalanine residue to L-3'-bromophenylalanine. 2076468 PubMed 9033387 PubMed AA0175 RESID (S)-2-amino-3-(3-bromophenyl)propanoic acid RESID-systematic 3'BrPhe PSI-MOD-label bromination UniMod-description Bromo PSI-MS-label L-3'-bromophenylalanine RESID-name m-bromophenylalanine RESID-alternate meta-bromophenylalanine RESID-alternate DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910512 Formula Br 1 C 9 H 8 N 1 O 1 MassAvg 226.07 MassMono 224.978926 Origin F Source natural TermSpec none MOD:00972 PSI-MOD MOD:00185 L-4'-bromophenylalanine A protein modification that effectively converts an L-phenylalanine residue to L-4'-bromophenylalanine. 2076468 PubMed 9033387 PubMed AA0176 RESID (2S)-2-amino-3-(4-bromophenyl)propanoic acid RESID-systematic 4'BrPhe PSI-MOD-label bromination UniMod-description Bromo PSI-MS-label L-4'-bromophenylalanine RESID-name p-bromophenylalanine RESID-alternate para-bromophenylalanine RESID-alternate DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910512 Formula Br 1 C 9 H 8 N 1 O 1 MassAvg 226.07 MassMono 224.978926 Origin F Source natural TermSpec none MOD:00972 PSI-MOD MOD:00186 3',3'',5'-triiodo-L-thyronine A protein modification that effectively substitutes an L-tyrosine residue with 3',3'',5'-triiodo-L-thyronine. 18258 ChEBI 0 DeltaMass AA0177 RESID 397 UniMod From DeltaMass: Average Mass: 470. PSI-MOD-slim (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid RESID-systematic 3',3'',5'-triiodo-L-thyronine RESID-name 3,3',5-triiodo-L-thyronine RESID-alternate 3,5,3'-triiodo-L-thyronine RESID-alternate 3,5,3'-Triiodothyronine (from Tyrosine) DeltaMass-label 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine RESID-alternate I3Thy PSI-MOD-label liothyronine RESID-alternate MOD_RES Triiodothyronine UniProt-feature O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine RESID-alternate T3 RESID-alternate triiodo UniMod-description Triiodothyronine PSI-MS-label DiffAvg 469.79 DiffFormula C 6 H 1 I 3 N 0 O 1 DiffMono 469.716158 Formula C 15 H 10 I 3 N 1 O 3 MassAvg 632.96 MassMono 632.779486 Origin Y Source natural TermSpec none MOD:00502 MOD:00998 PSI-MOD MOD:00187 L-thyroxine A protein modification that effectively substitutes an L-tyrosine residue with L-thyroxine. 18332 ChEBI 6704086 PubMed AA0178 RESID 398 UniMod PSI-MOD-slim (S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid RESID-systematic 3',3'',5',5''-tetraiodo-L-thyronine RESID-alternate 3,3',5,5'-tetraiodo-L-thyronine RESID-alternate 3,5,3',5'-tetraiodo-L-thyronine RESID-alternate 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine RESID-alternate I4Thy PSI-MOD-label L-thyroxine RESID-name MOD_RES Thyroxine UniProt-feature O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine RESID-alternate T4 RESID-alternate tetraiodo UniMod-description Thyroxine PSI-MS-label DiffAvg 595.68 DiffFormula C 6 H 0 I 4 N 0 O 1 DiffMono 595.612805 Formula C 15 H 9 I 4 N 1 O 3 MassAvg 758.86 MassMono 758.676134 Origin Y Source natural TermSpec none MOD:00998 PSI-MOD MOD:00188 6'-bromo-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 6'-bromo-L-tryptophan. 12118011 PubMed 9030520 PubMed 9033387 PubMed 9434739 PubMed AA0179 RESID 340#W UniMod (2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid RESID-systematic 6'-bromo-L-tryptophan RESID-name 6'-BrTrp PSI-MOD-label bromination UniMod-description Bromo PSI-MS-label MOD_RES 6'-bromotryptophan UniProt-feature DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910512 Formula Br 1 C 11 H 9 N 2 O 1 MassAvg 265.11 MassMono 263.989825 Origin W Source natural TermSpec none MOD:01068 MOD:01912 PSI-MOD MOD:00189 dehydroalanine (Ser) A protein modification that effectively converts an L-serine residue to dehydroalanine. 0 DeltaMass 10220322 PubMed 1547888 PubMed 1815586 PubMed 2914619 PubMed 7947813 PubMed 8239649 PubMed AA0181#SER RESID 23#S UniMod PSI-MOD-slim 2,3-didehydroalanine RESID-alternate 2-aminoacrylic acid RESID-alternate 2-aminopropenoic acid RESID-systematic 4-methylidene-imidazole-5-one (MIO) active site RESID-alternate anhydroserine RESID-alternate beta-elim-s OMSSA-label Dehydrated PSI-MS-label dehydro OMSSA-label dehydroalanine RESID-name Dha RESID-alternate Dha(Ser) PSI-MOD-label MOD_RES 2,3-didehydroalanine (Ser) UniProt-feature phospholosss OMSSA-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 3 H 3 N 1 O 1 MassAvg 69.06 MassMono 69.021464 Origin S Source natural TermSpec none MOD:00416 MOD:00916 MOD:01168 PSI-MOD MOD:00190 dehydrobutyrine (Thr) A protein modification that effectively converts an L-threonine residue to dehydrobutyrine. 0 DeltaMass 1547888 PubMed 3769923 PubMed AA0182 RESID 23#T UniMod PSI-MOD-slim (2Z)-2-aminobut-2-enoic acid RESID-systematic (Z)-2-amino-2-butenoic acid RESID-alternate (Z)-2-aminobutenoic acid RESID-alternate (Z)-dehydrobutyrine RESID-name 2,3-didehydrobutyrine RESID-alternate 3-methyldehydroalanine RESID-alternate alpha,beta-dehydroaminobutyric acid RESID-alternate anhydrothreonine RESID-alternate beta-elim-t OMSSA-label Dehydrated PSI-MS-label Dehydrated UniMod-interim Dehydration UniMod-description dehydro OMSSA-label Dehydroamino butyric acid DeltaMass-label Dhb RESID-alternate Dhb(Thr) PSI-MOD-label methyl-dehydroalanine RESID-alternate MOD_RES (Z)-2,3-didehydrobutyrine UniProt-feature phospholosst OMSSA-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 4 H 5 N 1 O 1 MassAvg 83.09 MassMono 83.037114 Origin T Source natural TermSpec none MOD:00416 MOD:00917 MOD:01703 PSI-MOD MOD:00191 (Z)-2,3-didehydrotyrosine A protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine. 1347277 PubMed 9631087 PubMed AA0183 RESID incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 PSI-MOD-slim (2Z)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid RESID-systematic (Z)-2,3-didehydrogenated tyrosine PSI-MOD-alternate (Z)-2,3-didehydrotyrosine RESID-name 2-amino-3-oxo-butanoic_acid UniMod-description amino-(para-hydroxybenzylidenyl)acetic acid RESID-alternate cis-dehydrotyrosine RESID-alternate Didehydro PSI-MS-label green fluorescent protein chromophore RESID-alternate MOD_RES (Z)-2,3-didehydrotyrosine UniProt-feature para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate red fluorescent protein chromophore RESID-alternate Z-dHTyr PSI-MOD-label DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 9 H 7 N 1 O 2 MassAvg 161.16 MassMono 161.047678 Origin Y Source natural TermSpec none MOD:00706 PSI-MOD MOD:00192 L-serine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine. 21393 ChEBI 1347277 PubMed 9631087 PubMed AA0184 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. (2-[(1R)-1-amino-2-hydroxyethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid RESID-systematic 2-[1-amino-2-hydroxyethyl]-1-carboxymethyl-1-imidazolin-5-one RESID-alternate 4-methylidene-imidazole-5-one (MIO) active site RESID-alternate CROSSLNK 5-imidazolinone (Ser-Gly) UniProt-feature green fluorescent protein chromophore RESID-alternate L-serine 5-imidazolinone glycine RESID-name para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate seryl-5-imidazolinone glycine RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 5 H 6 N 2 O 2 MassAvg 126.11 MassMono 126.042927 Origin G, S Source natural TermSpec none MOD:00908 MOD:00916 MOD:01882 PSI-MOD MOD:00193 L-3-oxoalanine (Cys) A protein modification that effectively converts an L-cysteine residue to L-oxoalanine. 350 DeltaMass 14563551 PubMed 7628016 PubMed 8681943 PubMed 9478923 PubMed AA0185#CYS RESID 402#C UniMod PSI-MOD-slim (S)-2-amino-3-oxopropanoic acid RESID-systematic 2-amino-3-oxopropionic acid RESID-alternate C(alpha)-formylglycine RESID-misnomer L-3-oxoalanine RESID-name L-amino-malonic acid semialdehyde RESID-alternate L-aminomalonaldehydic acid RESID-alternate L-serinesemialdehyde RESID-misnomer MOD_RES 3-oxoalanine (Cys) UniProt-feature Oxala(Cys) PSI-MOD-label DiffAvg -18.08 DiffFormula C 0 H -2 N 0 O 1 S -1 DiffMono -17.992806 Formula C 3 H 3 N 1 O 2 MassAvg 85.06 MassMono 85.016378 Origin C Source natural TermSpec none MOD:01169 PSI-MOD MOD:00194 lactic acid A protein modification that effectively converts an L-serine residue to an amino-terminal lactic acid. 7607233 PubMed AA0186 RESID 403#S UniMod (2R)-2-hydroxypropanoic acid RESID-systematic 2-hydroxypropionic acid RESID-alternate alpha-hydroxypropionic acid RESID-alternate Lac(Ser) PSI-MOD-label lactic acid RESID-name lactic acid from N-term Ser UniMod-description MOD_RES Lactic acid UniProt-feature Ser->LacticAcid PSI-MS-label DiffAvg -15.02 DiffFormula C 0 H -1 N -1 O 0 DiffMono -15.010899 Formula C 3 H 5 O 2 MassAvg 73.07 MassMono 73.028954 Origin S TermSpec N-term MOD:00916 PSI-MOD MOD:00195 L-alanine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine. 10220322 PubMed AA0187 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. (2-[(1S)-1-aminoethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid RESID-systematic 2-[1-aminoethyl]-1-carboxymethyl-1-imidazolin-5-one RESID-alternate 4-methylidene-imidazole-5-one active site RESID-alternate alanyl-5-imidazolinone glycine RESID-alternate CROSSLNK 5-imidazolinone (Ala-Gly) UniProt-feature L-alanine 5-imidazolinone glycine RESID-name para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate XLNK-1Ala-NGly(Imidazole) PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 5 H 6 N 2 O 1 MassAvg 110.12 MassMono 110.048013 Origin A, G Source natural TermSpec none MOD:00901 MOD:00908 MOD:01882 PSI-MOD MOD:00196 L-cysteine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine. 1537807 PubMed AA0188 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. (2-[(1R)-1-amino-2-sulfanylethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid RESID-systematic 2-[1-amino-2-sulfanylethyl]-1-carboxymethyl-1-imidazolin-5-one RESID-alternate 4-methylidene-imidazole-5-one (MIO) active site RESID-alternate CROSSLNK 5-imidazolinone (Cys-Gly) UniProt-feature cysteinyl-5-imidazolinone glycine RESID-alternate L-cysteine 5-imidazolinone glycine RESID-name para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate XLNK-1Cys-NGly(Imidazole) PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 5 H 6 N 2 O 1 S 1 MassAvg 142.18 MassMono 142.020084 Origin C, G Source natural TermSpec none MOD:00905 MOD:00908 MOD:01882 PSI-MOD MOD:00197 2-imino-glutamine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine. 11050230 PubMed 11209050 PubMed AA0189 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. 2,N-didehydroglutaminyl-5-imidazolinone glycine RESID-alternate 2-(3-carbamoyl-1-imino-propyl)-1-carboxymethyl-1-imidazolin-5-one RESID-alternate 2-imino-glutamine 5-imidazolinone glycine RESID-name [2-(3-carbamoyl-1-imino-propyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid RESID-alternate [2-(4-amino-4-oxobutanimidoyl)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid RESID-systematic CROSSLNK 2-iminomethyl-5-imidazolinone (Gln-Gly) UniProt-feature fluorescent protein FP583 chromophore RESID-alternate para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate red fluorescent protein chromophore RESID-alternate DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 DiffMono -20.026215 Formula C 7 H 7 N 3 O 2 MassAvg 165.15 MassMono 165.053826 Origin G, Q Source natural TermSpec none MOD:00907 MOD:00908 MOD:01882 PSI-MOD MOD:00198 D-alanine (Ala) A protein modification that effectively converts an L-alanine residue to D-alanine. 15023056 PubMed 7287302 PubMed 7961627 PubMed AA0191#ALA RESID (R)-2-aminopropanoic acid RESID-systematic D-Ala(Ala) PSI-MOD-label D-alanine RESID-name MOD_RES D-alanine (Ala) UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin A Source natural TermSpec none MOD:00570 MOD:00862 MOD:00901 PSI-MOD MOD:00199 D-allo-isoleucine A protein modification that effectively converts an L-isoleucine residue to a D-allo-isoleucine. 30007 ChEBI 8223491 PubMed AA0192 RESID (2R,3S)-2-amino-3-methylpentanoic acid RESID-systematic 2-azanyl-3-methylpentanoic acid RESID-alternate 3-methyl-norvaline RESID-alternate allo-D-isoleucine RESID-alternate alpha-amino-beta-methylvaleric acid RESID-alternate D-allo-isoleucine RESID-name D-Ile PSI-MOD-label D-threo-isoleucine RESID-alternate MOD_RES D-allo-isoleucine UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin I Source natural TermSpec none MOD:00306 MOD:00664 MOD:00910 PSI-MOD MOD:00200 D-methionine A protein modification that effectively converts an L-methionine residue to D-methionine. 29984 ChEBI 16033333 PubMed 2542051 PubMed AA0193 RESID (2R)-2-amino-4-(methylsulfanyl)butanoic acid RESID-systematic 2-amino-4-(methylthio)butanoic acid RESID-alternate 2-amino-4-(methylthio)butyric acid RESID-alternate D-Met PSI-MOD-label D-methionine RESID-name MOD_RES D-methionine UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 S 0 DiffMono 0.000000 Formula C 5 H 9 N 1 O 1 S 1 MassAvg 131.19 MassMono 131.040485 Origin M Source natural TermSpec none MOD:00664 MOD:00913 PSI-MOD MOD:00201 D-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to D-phenylalanine. 29996 ChEBI 1548227 PubMed 1644179 PubMed 2597281 PubMed AA0194 RESID (R)-2-amino-3-phenylpropanoic acid RESID-systematic D-Phe PSI-MOD-label D-phenylalanine RESID-name MOD_RES D-phenylalanine UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 9 H 9 N 1 O 1 MassAvg 147.18 MassMono 147.068414 Origin F Source natural TermSpec none MOD:00664 MOD:00914 PSI-MOD MOD:00202 D-serine (Ser) A protein modification that effectively converts an L-serine residue to D-serine. 7973665 PubMed AA0195#SER RESID (R)-2-amino-3-hydroxypropanoic acid RESID-systematic D-Ser(Ser) PSI-MOD-label D-serine RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 3 H 5 N 1 O 2 MassAvg 87.08 MassMono 87.032028 Origin S Source natural TermSpec none MOD:00891 MOD:00916 PSI-MOD MOD:00203 D-asparagine A protein modification that effectively converts an L-asparagine residue to D-asparagine. 29957 ChEBI 1859408 PubMed AA0196 RESID (R)-2-amino-4-butanediamic acid RESID-systematic D-alpha-aminosuccinamic acid RESID-alternate D-Asn PSI-MOD-label D-asparagine RESID-name D-aspartic acid beta-amide RESID-alternate MOD_RES D-asparagine UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 6 N 2 O 2 MassAvg 114.10 MassMono 114.042927 Origin N Source natural TermSpec none MOD:00664 MOD:00903 PSI-MOD MOD:00204 D-leucine A protein modification that effectively converts an L-leucine residue to D-leucine. 30005 ChEBI 10461743 PubMed 12135762 PubMed 1358533 PubMed 1548227 PubMed AA0197 RESID (2R)-2-amino-4-methylpentanoic acid RESID-systematic alpha-aminoisocaproic acid RESID-alternate D-Leu PSI-MOD-label D-leucine RESID-name MOD_RES D-leucine UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin L Source natural TermSpec none MOD:00306 MOD:00664 MOD:00911 PSI-MOD MOD:00205 D-tryptophan A protein modification that effectively converts an L-tryptophan residue to D-tryptophan. 29955 ChEBI 8910408 PubMed AA0198 RESID (R)-2-amino-3-(1H-indol-3-yl)propanoic acid RESID-systematic alpha-amino-beta-(3-indolyl)propionoic acid RESID-alternate D-Trp PSI-MOD-label D-tryptophan RESID-name MOD_RES D-tryptophan UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 11 H 10 N 2 O 1 MassAvg 186.21 MassMono 186.079313 Origin W Source natural TermSpec none MOD:00664 MOD:00918 PSI-MOD MOD:00206 L-isoglutamyl-polyglycine A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine. 21343 ChEBI 10074368 PubMed 16368691 PubMed 7992051 PubMed AA0201 RESID gamma-glutamylpolyglycine RESID-alternate L-isoglutamyl-polyglycine RESID-name MOD_RES 5-glutamyl polyglycine UniProt-feature DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula C 7 H 10 N 2 O 4 MassAvg 186.17 MassMono 186.064057 Origin E Source natural TermSpec none MOD:00906 PSI-MOD MOD:00207 L-isoglutamyl-polyglutamic acid A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid. 10747868 PubMed 1680872 PubMed AA0202 RESID gamma-glutamylpolyglutamic acid RESID-alternate L-isoglutamyl-polyglutamic acid RESID-name DiffAvg 129.12 DiffFormula C 5 H 7 N 1 O 3 DiffMono 129.042593 Formula C 10 H 14 N 2 O 6 MassAvg 258.23 MassMono 258.085186 Origin E Source natural TermSpec none MOD:00674 MOD:00906 PSI-MOD MOD:00208 O4'-(phospho-5'-adenosine)-L-tyrosine A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine. 0 DeltaMass 5543675 PubMed AA0203 RESID 405#Y UniMod From DeltaMass: Average Mass: 329. PSI-MOD-slim (2S)-2-amino-3-[4-(5'-adenosine phosphonoxy)phenyl]propanoic acid RESID-systematic 5'-adenylic-O-tyrosine RESID-alternate AMP binding site UniMod-description hydrogen 5'-adenylate tyrosine ester RESID-alternate MOD_RES O-AMP-tyrosine UniProt-feature O-5'-Adenosylation ( of Tyrosine) DeltaMass-label O4'-(phospho-5'-adenosine)-L-tyrosine RESID-name O4'-L-tyrosine 5'-adenosine phosphodiester RESID-alternate OAMPTyr PSI-MOD-label Phosphoadenosine PSI-MS-label DiffAvg 329.21 DiffFormula C 10 H 12 N 5 O 6 P 1 DiffMono 329.052520 Formula C 19 H 21 N 6 O 8 P 1 MassAvg 492.38 MassMono 492.115848 Origin Y Source natural TermSpec none MOD:00919 MOD:01165 PSI-MOD MOD:00209 S-(2-aminovinyl)-D-cysteine (Cys-Ser) A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. 3181159 PubMed 3769923 PubMed AA0204#SER RESID Cross-link 2. (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid RESID-systematic (S,Z)-S-(2-aminovinyl)cysteine RESID-alternate CROSSLNK S-(2-aminovinyl)-D-cysteine (Ser-Cys) UniProt-feature S-(2-aminovinyl)-D-cysteine RESID-name XLNK-(D)SCys-VinAm PSI-MOD-label DiffAvg -64.04 DiffFormula C -1 H -4 N 0 O -3 S 0 DiffMono -64.016044 Formula C 5 H 7 N 2 O 1 S 1 MassAvg 143.18 MassMono 143.027909 Origin C, S TermSpec C-term MOD:00916 MOD:01850 PSI-MOD MOD:00210 L-cysteine sulfenic acid A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid. 41 DeltaMass 10964927 PubMed 2501303 PubMed 8756456 PubMed 9214307 PubMed 9586994 PubMed 9587003 PubMed AA0205 RESID 35#C UniMod From DeltaMass: Average Mass: 16 Average Mass Change:16 Notes:Green et al. in J. B. C. 270, 18209-18211 (1995) quote Kim and Raines in Eur. J. Biochem. 224, 109-114 (1994). Kim and Raines using ESI-MS and sulfhydryl group titration found that bovine seminal ribonuclease contains a single oxidized sulfhydryl group, which cannot participate in a disulfide bond. This form of cysteine is called sulfenic acid (-SOH). PSI-MOD-slim (2R)-2-amino-3-(hydroxysulfanyl)propanoic acid RESID-systematic (2R)-2-amino-3-(oxido-lambda(4)-sulfanyl)propanoic acid [tautomer] RESID-alternate 2-amino-2-carboxyethanesulfenic acid RESID-alternate 2-amino-3-sulfinylpropanoic acid [tautomer] RESID-alternate 3-sulfenoalanine RESID-alternate ACT_SITE Cysteine sulfenic acid (-SOH) intermediate UniProt-feature CysOH PSI-MOD-label cysteine S-oxide [tautomer] RESID-alternate cysteine sulfoxide [tautomer] RESID-alternate cysteine sulphenic acid RESID-alternate L-cysteine sulfenic acid RESID-name mod193 OMSSA-label MOD_RES Cysteine sulfenic acid (-SOH) UniProt-feature Oxidation PSI-MS-label S-hydroxycysteine RESID-alternate S-oxocysteine [tautomer] RESID-alternate S-oxycysteine [tautomer] RESID-alternate Sulfenic Acid (from Cysteine) DeltaMass-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 S 0 DiffMono 15.994915 Formula C 3 H 5 N 1 O 2 S 1 MassAvg 119.14 MassMono 119.004099 Origin C Source natural TermSpec none MOD:00708 MOD:01854 PSI-MOD MOD:00211 S-(glycyl)-L-cysteine (Cys-Gly) A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine. 22050 ChEBI 3306404 PubMed AA0206 RESID Cross-link 2. For the modification of a C-terminal glycine by formation of a thioester bond with free L-cycteine see MOD:01777 [JSG]. PSI-MOD-slim (2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid RESID-systematic 1-(cystein-S-yl)-glycinate RESID-alternate ACT_SITE Glycyl thioester intermediate UniProt-feature glycine cysteine thioester RESID-alternate S-(2-amino-1-oxoethyl)cysteine RESID-alternate S-(glycyl)-L-cysteine RESID-name XLNK-SCys-1Gly PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 5 H 7 N 2 O 2 S 1 MassAvg 159.18 MassMono 159.022823 Origin C, G TermSpec C-term MOD:00395 MOD:00908 MOD:00954 PSI-MOD MOD:00212 S-4-hydroxycinnamyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-4-hydroxycinnamyl-L-cysteine. 7947803 PubMed 7981196 PubMed AA0207 RESID 407 UniMod (2R)-2-amino-3-([(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanyl)propanoic acid RESID-systematic cinnamate cysteine thioester RESID-alternate Hydroxycinnamyl PSI-MS-label hydroxycinnamyl UniMod-description MOD_RES S-(4-hydroxycinnamyl)cysteine UniProt-feature S-4-hydroxycinnamyl-L-cysteine RESID-name S-para-coumaryl-L-cysteine RESID-alternate DiffAvg 146.14 DiffFormula C 9 H 6 N 0 O 2 S 0 DiffMono 146.036779 Formula C 12 H 11 N 1 O 3 S 1 MassAvg 249.28 MassMono 249.045964 Origin C Source natural TermSpec none MOD:00905 PSI-MOD MOD:00213 chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine A protein modification that effectively cross-links an L-serine residue to the polymer chondroitin sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. 1794445 PubMed 1898736 PubMed 3472204 PubMed AA0208 RESID chondroitin 4-sulfate (chondroitin sulfate A) RESID-alternate chondroitin 6-sulfate (chondroitin sulfate C) RESID-alternate chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine RESID-name poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine; poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-6-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine RESID-systematic DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007825 Formula C 3 H 4 N 1 O 2 MassAvg 86.07 MassMono 86.024203 Origin S Source natural TermSpec none MOD:00002 PSI-MOD MOD:00214 dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine A protein modification that effectively cross-links an L-serine residue to the polymer dermatan 4-sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. 2914936 PubMed 3472204 PubMed AA0209 RESID beta-heparin RESID-alternate chondroitin sulfate B RESID-alternate dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine RESID-name poly[beta-1,4-L-idopyranuronosyl-alpha-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine RESID-systematic DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007825 Formula C 3 H 4 N 1 O 2 MassAvg 86.07 MassMono 86.024203 Origin S Source natural TermSpec none MOD:00002 PSI-MOD MOD:00215 heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine A protein modification that effectively cross-links an L-serine residue to the polymer heparan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. 3472204 PubMed AA0210 RESID heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine RESID-name heparin RESID-alternate heparitin sulfate RESID-alternate poly[alpha-1,4-(2-sulfate D-glucopyranuronosyl)-beta-1,4-(2-sulfamino-2-deoxy-6-sulfate D-glucosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine RESID-systematic DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007825 Formula C 3 H 4 N 1 O 2 MassAvg 86.07 MassMono 86.024203 Origin S Source natural TermSpec none MOD:00002 PSI-MOD MOD:00216 N6-formyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-formyl-L-lysine. 15799070 PubMed AA0211 RESID 122#K UniMod PSI-MOD-slim (2S)-2-amino-6-(formylamino)hexanoic acid RESID-systematic epsilon-formyllysine RESID-alternate Formyl PSI-MS-label Formylation UniMod-description formylk OMSSA-label MOD_RES N6-formyllysine UniProt-feature N(zeta)-formyllysine RESID-alternate N6-formyl-L-lysine RESID-name N6-formylated L-lysine PSI-MOD-alternate N6FoLys PSI-MOD-label DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 7 H 12 N 2 O 2 MassAvg 156.19 MassMono 156.089878 Origin K Source natural TermSpec none MOD:00409 MOD:01875 PSI-MOD MOD:00217 O4-arabinosyl-L-hydroxyproline A protein modification that effectively converts an L-proline residue to O4-arabinosyl-L-hydroxyproline. 0 DeltaMass 666730 PubMed 7852316 PubMed AA0212 RESID 408 UniMod secondary to RESID:AA0030; From DeltaMass: Average Mass: 147. PSI-MOD-slim (2S,4R)-4-(beta-L-arabinofuranosyloxy)pyrrolidine-2-carboxylic acid RESID-systematic 4-(beta-L-arabinofuranosyloxy)proline RESID-alternate 4-Glycosyloxy- (pentosyl,C5) (of Proline) DeltaMass-label beta-arabinofuranosyl-4-hydroxyproline RESID-alternate Glycosyl PSI-MS-label glycosyl-L-hydroxyproline UniMod-description O4-arabinosyl-L-hydroxyproline RESID-name O4-glycosyl-hydroxyproline RESID-alternate OAra4HyPro PSI-MOD-label DiffAvg 148.11 DiffFormula C 5 H 8 N 0 O 5 DiffMono 148.037173 Formula C 10 H 15 N 1 O 6 MassAvg 245.23 MassMono 245.089937 Origin P Source natural TermSpec none MOD:00396 MOD:00915 PSI-MOD MOD:00218 O-(phospho-5'-RNA)-L-serine A protein modification that effectively crosslinks an L-serine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-serine. 1705009 PubMed AA0213 RESID (S)-2-amino-3-(5'-ribonucleic acid phosphonoxy)propanoic acid RESID-systematic MOD_RES O-(5'-phospho-RNA)-serine UniProt-feature O-(phospho-5'-RNA)-L-serine RESID-name O3-(phospho-5'-RNA)-L-serine RESID-alternate O3-L-serine 5'-RNA phosphodiester RESID-alternate DiffAvg 78.97 DiffFormula C 0 H 0 N 0 O 3 P 1 DiffMono 78.958505 Formula C 3 H 5 N 1 O 5 P 1 MassAvg 166.05 MassMono 165.990534 Origin S Source natural TermSpec none MOD:00751 MOD:00916 PSI-MOD MOD:00219 L-citrulline A protein modification that effectively converts an L-arginine residue to L-citrulline. 0 DeltaMass 2466844 PubMed AA0214 RESID 7#R UniMod This modification is not the result of deamidation, instead the guanidino group is replaced with an ureido group. PSI-MOD-slim (S)-2-amino-5-(carbamoylamino)pentanoic acid RESID-systematic 2-amino-5-(aminocarbonyl)aminopentanoic acid RESID-alternate alpha-amino-delta-ureidovaleric acid RESID-alternate Cit PSI-MOD-label citrullinationr OMSSA-label Citrulline DeltaMass-label Deamidated PSI-MS-label Deamidated UniMod-interim Deamidation UniMod-description delta-ureidonorvaline RESID-alternate L-citrulline RESID-name MOD_RES Citrulline UniProt-feature N5-(aminocarbonyl)ornithine RESID-alternate N5-carbamoylornithine RESID-alternate N5-carbamylornithine RESID-alternate DiffAvg 0.98 DiffFormula C 0 H -1 N -1 O 1 DiffMono 0.984016 Formula C 6 H 11 N 3 O 2 MassAvg 157.17 MassMono 157.085127 Origin R Source natural TermSpec none MOD:00902 PSI-MOD MOD:00220 4-hydroxy-L-arginine A protein modification that effectively converts an L-arginine residue to a 4-hydroxy-L-arginine. 10966817 PubMed 7650037 PubMed AA0215 RESID (2S,4Xi)-2-amino-5-[(diaminomethylidene)amino]-4-hydroxypentanoic acid RESID-systematic 2-amino-5-(carbamimidamido)-4-hydroxypentanoic acid [tautomer] RESID-alternate 2-amino-5-[(aminoiminomethyl)amino]-4-hydroxypentanoic acid [tautomer] RESID-alternate 2-amino-5-guanidino-4-hydroxypentanoic acid RESID-alternate 4-hydroxy-L-arginine RESID-name 4-hydroxylated L-arginine PSI-MOD-alternate 4HyArg PSI-MOD-label C(gamma)-hydroxyarginine RESID-alternate gamma-hydroxyarginine RESID-alternate MOD_RES 4-hydroxyarginine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 12 N 4 O 2 MassAvg 172.19 MassMono 172.096026 Origin R Source natural TermSpec none MOD:00425 MOD:00682 PSI-MOD MOD:00221 N-(L-isoaspartyl)-L-cysteine A protein modification that effectively crosslinks L-aspartic acid and L-cysteine residues via an isopeptide bond to form N-(L-isoaspartyl)-L-cysteine. 8286361 PubMed AA0216 RESID Cross-link 2. (S)-2-amino-4-((R)-1-carboxy-2-sulfanylethyl)amino-4-oxobutanoic acid RESID-systematic 2-(3-amino-3-carboxypropanoyl)amino-3-mercaptopropanoic acid RESID-alternate 2-amino-N4-(1-carboxy-2-mercaptoethyl)butanediamic acid RESID-alternate CROSSLNK Isoaspartyl cysteine isopeptide (Cys-Asn) UniProt-feature N-(L-isoaspartyl)-L-cysteine RESID-name N-beta-aspartylcysteine RESID-alternate N-isoaspartyl cysteine RESID-alternate DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 S 0 DiffMono -17.026549 Formula C 7 H 9 N 2 O 3 S 1 MassAvg 201.22 MassMono 201.033388 Origin C, N Source natural TermSpec N-term MOD:00903 MOD:00905 PSI-MOD MOD:00222 2'-alpha-mannosyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 2'-alpha-mannosyl-L-tryptophan. 15279557 PubMed 7547911 PubMed 7947762 PubMed AA0217 RESID 41#W UniMod (2S)-2-amino-3-(2-beta-D-mannopyranosyl-1H-indol-3-yl)propanoic acid RESID-systematic 2'-mannosyl-L-tryptophan RESID-name 2'-tryptophan C-mannoside RESID-alternate C2'ManTrp PSI-MOD-label CARBOHYD C-linked (Man) UniProt-feature Hex PSI-MS-label Hexose UniMod-description DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 17 H 20 N 2 O 6 MassAvg 348.36 MassMono 348.132136 Origin W Source natural TermSpec none MOD:00421 MOD:00595 MOD:00761 MOD:00918 PSI-MOD MOD:00223 N6-mureinyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-mureinyl-L-lysine. 4261992 PubMed AA0218 RESID MOD_RES N6-murein peptidoglycan lysine UniProt-feature N6-[(2R,6S)-2-(N-(N-mureinyl-(R)-alanyl)-(S)-glutamyl)amino-6-amino-6-carboxy-1-oxohex-1-yl]lysine RESID-alternate N6-mureinyl-L-lysine RESID-name DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007825 Formula C 6 H 11 N 2 O 1 MassAvg 127.17 MassMono 127.087138 Origin K Source natural TermSpec none MOD:01159 MOD:01875 PSI-MOD MOD:00224 1-chondroitin sulfate-L-aspartic acid ester A protein modification that effectively converts an L-aspartic acid residue to 1-chondroitin sulfate-L-aspartic acid ester 1898736 PubMed AA0219 RESID 1-aspartic acid ester with 6-chondroitin 4-sulfate RESID-alternate 1-chondroitin sulfate-L-aspartic acid ester RESID-name MOD_RES Aspartate 1-(chondroitin 4-sulfate)-ester UniProt-feature poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-6-(1-L-aspartyl)-D-galactose) RESID-alternate protein-glycosaminoglycan-protein cross-link RESID-alternate DiffAvg 441.36 DiffFormula C 14 H 19 N 1 O 13 S 1 DiffMono 441.057711 Formula C 18 H 25 N 2 O 17 S 1 MassAvg 573.45 MassMono 573.087393 Origin D TermSpec C-term MOD:00904 PSI-MOD MOD:00225 S-(6-FMN)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(6-FMN)-L-cysteine. 10869173 PubMed 1551870 PubMed 620783 PubMed AA0220 RESID 409#C UniMod PSI-MOD-slim (R)-2-amino-3-[6-riboflavin 5'-dihydrogen phosphate]sulfanylpropanoic acid RESID-systematic 6-[S-cysteinyl]flavin mononucleotide RESID-alternate 6-[S-cysteinyl]FMN RESID-alternate flavin mononucleotide UniMod-description FMNH PSI-MS-label MOD_RES S-6-FMN cysteine UniProt-feature S-(6-FMN)-L-cysteine RESID-name S6FMNCys PSI-MOD-label DiffAvg 454.33 DiffFormula C 17 H 19 N 4 O 9 P 1 S 0 DiffMono 454.088965 Formula C 20 H 24 N 5 O 10 P 1 S 1 MassAvg 557.47 MassMono 557.098150 Origin C Source natural TermSpec none MOD:00896 MOD:00905 PSI-MOD MOD:00226 1'-(8alpha-FAD)-L-histidine A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine. 0 DeltaMass 10585424 PubMed 1396672 PubMed 4339951 PubMed 9261083 PubMed AA0221 RESID 50#H UniMod From DeltaMass: Average Mass: 784 PSI-MOD-slim (S)-2-amino-3-(1-[8alpha riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid RESID-systematic 1'-(8alpha-FAD)-L-histidine RESID-name 8alpha-(N(epsilon)-histidyl)FAD RESID-alternate 8alpha-(N1'-histidyl)FAD RESID-alternate 8alpha-N3-histidyl FAD RESID-misnomer FAD PSI-MS-label Flavin adenine dinucleotide UniMod-description MOD_RES Tele-8alpha-FAD histidine UniProt-feature N theta and N pi-(8alpha-Flavin) (on Histidine) DeltaMass-label N(tau)-(8alpha-FAD)-histidine RESID-alternate Nt8aFADHis PSI-MOD-label tele-(8alpha-FAD)-histidine RESID-alternate DiffAvg 783.54 DiffFormula C 27 H 31 N 9 O 15 P 2 DiffMono 783.141485 Formula C 33 H 38 N 12 O 16 P 2 MassAvg 920.68 MassMono 920.200396 Origin H Source natural TermSpec none MOD:00895 MOD:00909 PSI-MOD MOD:00227 omega-N-phospho-L-arginine A protein modification that effectively converts an L-arginine residue to omega-N-phospho-L-arginine. 8300603 PubMed AA0222 RESID 21#R UniMod PSI-MOD-slim (2S)-2-amino-5-([amino(phosphonoamino)methylidene]amino)pentanoic acid RESID-systematic (2S)-2-amino-5-(N'-phosphonocarbamimidamido)pentanoic acid RESID-alternate alpha-amino-delta-phosphonoguanidinovaleric acid RESID-alternate MOD_RES Phosphoarginine UniProt-feature N(gamma)-phosphoarginine RESID-alternate N(omega)-phosphono-L-arginine RESID-alternate N5-[imino(phosphonoamino)methyl]-L-ornithine RESID-alternate omega-N-phospho-L-arginine RESID-name PArg PSI-MOD-label Phospho PSI-MS-label phosphoarginine RESID-alternate Phosphorylation UniMod-description DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 6 H 13 N 4 O 4 P 1 MassAvg 236.17 MassMono 236.067442 Origin R Source natural TermSpec none MOD:00902 MOD:01456 PSI-MOD MOD:00228 S-diphytanylglycerol diether-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-diphytanylglycerol diether-L-cysteine. 7797461 PubMed 8195126 PubMed AA0223 RESID 410 UniMod incidental to RESID:AA0043. PSI-MOD-slim (2R)-2-amino-3-([(2S)-2,3-bis(3,7,11,15-tetramethylhexadecanyloxy)propyl]sulfanyl)propanoic acid RESID-systematic Archaeol PSI-MS-label LIPID S-archaeol cysteine UniProt-feature S-(diphytanylglyceryl)-L-cysteine RESID-name S-[2',3'-bis(phytanyloxy)propyl]cysteine RESID-alternate S-archaeol cysteine RESID-alternate S-diphytanylglycerol diether UniMod-description SPhyt2GlyceroCys PSI-MOD-label DiffAvg 635.16 DiffFormula C 43 H 86 N 0 O 2 S 0 DiffMono 634.662782 Formula C 46 H 91 N 1 O 3 S 1 MassAvg 738.30 MassMono 737.671967 Origin C Source natural TermSpec none MOD:00905 MOD:01155 PSI-MOD MOD:00229 alpha-1-microglobulin-Ig alpha complex chromophore A protein modification that effectively converts two L-cysteine residues to form alpha-1-microglobulin-Ig alpha complex chromophore. 11058759 PubMed 11877257 PubMed 7506257 PubMed 7535251 PubMed AA0224 RESID Cross-link 2. alpha-1-microglobulin-Ig alpha complex chromophore RESID-name BINDING Multimeric 3-hydroxykynurenine chromophore (covalent) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 2 S 2 MassAvg 204.26 MassMono 204.002720 Origin C, C Source natural TermSpec none MOD:00905 PSI-MOD MOD:00230 bis-L-cysteinyl bis-L-histidino diiron disulfide A protein modification that effectively converts two L-cysteine residues, two L-histidine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bis-L-histidino diiron disulfide. 2765515 PubMed 9651245 PubMed AA0225 RESID Cross-link 4. bis-L-cysteinyl bis-L-histidino diiron disulfide RESID-name di-mu-sulfido(bis-S-cysteinyliron)(bis-N3'-histidinoiron) RESID-systematic METAL Iron-sulfur (2Fe-2S) UniProt-feature METAL Iron-sulfur (2Fe-2S); via pros nitrogen UniProt-feature Rieske iron-sulfur cofactor RESID-alternate DiffAvg 171.78 DiffFormula C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono 171.783814 FormalCharge 2- Formula C 18 Fe 2 H 20 N 8 O 4 S 4 MassAvg 652.34 MassMono 651.920007 Origin C, C, H, H Source natural TermSpec none MOD:00739 MOD:00905 MOD:00909 PSI-MOD MOD:00231 hexakis-L-cysteinyl hexairon hexasulfide A protein modification that effectively converts six L-cysteine residues and a six-iron six-sulfur cluster to hexakis-L-cysteinyl hexairon hexasulfide. 1311311 PubMed 1318833 PubMed AA0226 RESID Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. hexa-mu3-sulfido-hexakis(cysteinato-kappaS)-hexairon RESID-systematic hexa-mu3-sulfido-hexakis(S-cysteinyliron) RESID-alternate hexakis-L-cysteinyl hexairon hexasulfide RESID-name prismane iron-sulfur cofactor RESID-alternate DiffAvg 521.38 DiffFormula C 0 Fe 6 H -6 N 0 O 0 S 6 DiffMono 521.395649 FormalCharge 1- Formula C 18 Fe 6 H 24 N 6 O 6 S 12 MassAvg 1140.22 MassMono 1139.450758 Origin C, C, C, C, C, C Source hypothetical TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00232 N6-(phospho-5'-adenosine)-L-lysine A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form N6-(phospho-5'-adenosine)-L-lysine. 316 DeltaMass 3882425 PubMed 4944632 PubMed AA0227 RESID 405#K UniMod PSI-MOD-slim (2S)-2-amino-6-(5'-adenosine phosphonamino)hexanoic acid RESID-systematic 5'-adenylic-N6-L-lysine RESID-alternate ACT_SITE N6-AMP-lysine intermediate UniProt-feature AMP binding site UniMod-description AMP Lysyl DeltaMass-label epsilon-5'-adenylic-L-lysine RESID-alternate L-lysine monoanhydride with 5'-adenylic acid RESID-alternate N(zeta)-5'-adenylic-L-lysine RESID-alternate N6-(phospho-5'-adenosine)-L-lysine RESID-name N6-L-lysine 5'-adenosine phosphoramidester RESID-alternate N6AMPLys PSI-MOD-label Phosphoadenosine PSI-MS-label DiffAvg 329.21 DiffFormula C 10 H 12 N 5 O 6 P 1 DiffMono 329.052520 Formula C 16 H 24 N 7 O 7 P 1 MassAvg 457.38 MassMono 457.147483 Origin K Source natural TermSpec none MOD:00912 MOD:01165 PSI-MOD MOD:00233 N6-(phospho-5'-guanosine)-L-lysine A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoguanosine through a phosphoramide ester bond to form N6-(phospho-5'-guanosine)-L-lysine. 304 DeltaMass 6092377 PubMed 6264433 PubMed AA0228 RESID 413#K UniMod From DeltaMass: Average Mass: 345 Formula:C10H12O5N7P1 Monoisotopic Mass Change:345.047 Average Mass Change:345.209 References:PE Sciex PSI-MOD-slim (2S)-2-amino-6-(5'-guanosine phosphonamino)hexanoic acid RESID-systematic 5'-guanylic-N6-L-lysine RESID-alternate 5'phos Guanosyl DeltaMass-label ACT_SITE N6-GMP-lysine intermediate UniProt-feature epsilon-5'-guanylic-L-lysine RESID-alternate L-lysine monoanhydride with 5'-guanylic acid RESID-alternate lysine guanosine-5'-monophosphate RESID-alternate N(zeta)-5'-guanylic-lysine RESID-alternate N6-(5'-guanylyl)-lysine RESID-alternate N6-(phospho-5'-guanosine)-L-lysine RESID-name N6-L-lysine 5'-guanosine phosphoramidester RESID-alternate N6GMPLys PSI-MOD-label phospho-guanosine UniMod-description Phosphoguanosine PSI-MS-label DiffAvg 345.21 DiffFormula C 10 H 12 N 5 O 7 P 1 DiffMono 345.047434 Formula C 16 H 24 N 7 O 8 P 1 MassAvg 473.38 MassMono 473.142397 Origin K Source natural TermSpec none MOD:00912 MOD:01163 PSI-MOD MOD:00234 L-cysteine glutathione disulfide A protein modification that effectively converts an L-cysteine residue to S-glutathionyl-L-cysteine. 21264 ChEBI 0 DeltaMass 3083866 PubMed 8344916 PubMed AA0229 RESID 55 UniMod From DeltaMass: Average Mass: 305 PSI-MOD-slim (2S)-2-amino-3-((2S)-2-((4R)-4-amino-4-carboxyl-1-oxobutyl)amino-3-(carboxylmethyl)amino-3-oxo-propyl)dithio-propanoic acid RESID-systematic cysteinyl glutathione RESID-alternate Glutathionation DeltaMass-label Glutathione PSI-MS-label glutathione disulfide UniMod-description glutathionec OMSSA-label L-cysteine glutathione disulfide RESID-name L-gamma-glutamyl-L-cysteinyl-glycine (2-1')-disulfide with L-cysteine RESID-alternate MOD_RES S-glutathionyl cysteine UniProt-feature N-(N-gamma-glutamyl-cystinyl)-glycine RESID-alternate SGltCys PSI-MOD-label DiffAvg 305.30 DiffFormula C 10 H 15 N 3 O 6 S 1 DiffMono 305.068156 Formula C 13 H 20 N 4 O 7 S 2 MassAvg 408.44 MassMono 408.077341 Origin C Source natural TermSpec none MOD:00905 MOD:01862 PSI-MOD MOD:00235 S-nitrosyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-nitrosyl-L-cysteine. 10442087 PubMed 11562475 PubMed 15688001 PubMed 8626764 PubMed 8637569 PubMed AA0230 RESID 275 UniMod PSI-MOD-slim (2R)-2-amino-3-nitrososulfanyl-propanoic acid RESID-systematic L-cysteine nitrite ester RESID-alternate MOD_RES S-nitrosocysteine UniProt-feature Nitrosyl PSI-MS-label S-nitrosocysteine RESID-alternate S-nitrosyl-L-cysteine RESID-name S-nitrosylation UniMod-description SNOCys PSI-MOD-label DiffAvg 29.00 DiffFormula C 0 H -1 N 1 O 1 S 0 DiffMono 28.990164 Formula C 3 H 4 N 2 O 2 S 1 MassAvg 132.14 MassMono 131.999348 Origin C Source natural TermSpec none MOD:00905 PSI-MOD MOD:00236 N4-(ADP-ribosyl)-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-(ADP-ribosyl)-L-asparagine. 15842200 PubMed 2498316 PubMed AA0231 RESID 213#N UniMod (S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-4-oxobutanoic acid RESID-systematic ADP Ribose addition UniMod-description ADP-Ribosyl PSI-MS-label MOD_RES ADP-ribosylasparagine UniProt-feature N4-(ADP-ribosyl)-L-asparagine RESID-name N4-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-asparagine RESID-alternate N4-alpha-D-ribofuranosyl-L-asparagine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) RESID-alternate DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 19 H 27 N 7 O 15 P 2 MassAvg 655.41 MassMono 655.104036 Origin N Source natural TermSpec none MOD:00752 MOD:00903 PSI-MOD MOD:00237 L-beta-methylthioaspartic acid A protein modification that effectively converts an L-aspartic acid residue to L-beta-methylthioaspartic acid. 61 DeltaMass 15473684 PubMed 8844851 PubMed AA0232 RESID 39#D UniMod PSI-MOD-slim (2R,3Xi)-2-amino-3-(methylsulfanyl)butanedioic acid RESID-systematic 3-(methylthio)-L-aspartic acid RESID-name 3-carboxy-S-methyl-cysteine RESID-alternate 3-methylthio-aspartic acid RESID-alternate 3MeSAsp PSI-MOD-label beta-Methylthio-aspartic acid DeltaMass-label beta-methylthio-aspartic acid RESID-alternate Beta-methylthiolation UniMod-description bmethylthiold OMSSA-label Methylthio UniMod-interim methythiold OMSSA-label MOD_RES 3-methylthioaspartic acid UniProt-feature DiffAvg 46.09 DiffFormula C 1 H 2 N 0 O 0 S 1 DiffMono 45.987721 Formula C 5 H 7 N 1 O 3 S 1 MassAvg 161.18 MassMono 161.014664 Origin D Source natural TermSpec none MOD:00904 MOD:01153 PSI-MOD MOD:00238 5'-(N6-L-lysine)-L-topaquinone A protein modification that effectively cross-links an L-lysine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 5'-(N6-L-lysine)-L-topaquinone. 8688089 PubMed AA0233 RESID Cross-link 2; secondary to RESID:AA0147. 1-[(S)-5-amino-5-carboxypentyl]amino-2-[(S)-2-amino-2-carboxyethyl]-2,6-cyclohexadien-4,5-dione RESID-systematic 2'-(L-lys-N6-yl)-L-4',5'-topaquinone RESID-name 2'-(L-lysine)-L-tyrosyl-4',5'-quinone RESID-alternate CROSSLNK Lysine tyrosylquinone (Lys-Tyr) UniProt-feature CROSSLNK Lysine tyrosylquinone (Tyr-Lys) UniProt-feature LTQ RESID-alternate lysyl oxidase cofactor RESID-alternate DiffAvg 11.97 DiffFormula C 0 H -4 N 0 O 1 DiffMono 11.963614 Formula C 15 H 17 N 3 O 4 MassAvg 303.32 MassMono 303.121906 Origin K, Y Source natural TermSpec none MOD:00692 MOD:00912 MOD:00919 PSI-MOD MOD:00239 S-methyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-methyl-L-cysteine. 10660523 PubMed 11875433 PubMed 1339288 PubMed AA0234 RESID 34#C UniMod PSI-MOD-slim (R)-2-amino-3-(methylsulfanyl)propanoic acid RESID-systematic ACT_SITE S-methylcysteine intermediate UniProt-feature L-3-(methylthio)alanine RESID-alternate Methyl PSI-MS-label Methylation UniMod-description MOD_RES S-methylcysteine UniProt-feature S-methyl-L-cysteine RESID-name S-methylated L-cysteine PSI-MOD-alternate SMeCys PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 S 0 DiffMono 14.015650 Formula C 4 H 7 N 1 O 1 S 1 MassAvg 117.17 MassMono 117.024835 Origin C Source natural TermSpec none MOD:00654 MOD:01682 PSI-MOD MOD:00240 4-hydroxy-L-lysine A protein modification that effectively converts an L-lysine residue to 4-hydroxy-L-lysine. 4005040 PubMed AA0235 RESID This modification was not structurally confirmed. Later 5-hydroxy-L-lysine was found at a homologous position in the same protein from closely related species. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. (2S,4R)-2,6-diamino-4-hydroxyhexanoic acid RESID-systematic 4-hydroxy-L-lysine RESID-name 4-hydroxylated L-lysine PSI-MOD-alternate 4HyLys PSI-MOD-label alpha,epsilon-diamino-gamma-hydroxycaproic acid RESID-alternate L-threo-gamma-hydroxylysine RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 12 N 2 O 2 MassAvg 144.17 MassMono 144.089878 Origin K Source artifact TermSpec none MOD:01047 PSI-MOD MOD:00241 N4-hydroxymethyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-hydroxymethyl-L-asparagine. AA0236 RESID 414 UniMod N4-methyl-L-asparagine, see MOD:0079, was found at a homologous position of the same protein in a closely related species. Since the peptide containing this modification was obtained by enzymatic cleavage, not cyanogen bromide cleavage, it could have experienced oxidation of the following methionine residue, leading to the erroneous attribution of a mass of 29 for the modification rather than 14. comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. (2S)-2-amino-4-[(hydroxymethyl)amino]-4-oxobutanoic acid RESID-systematic 2-amino-N4-hydroxymethylbutanediamic acid RESID-alternate beta-hydroxymethylasparagine RESID-alternate Hydroxymethyl PSI-MS-label hydroxymethyl UniMod-description N(gamma)-hydroxymethylasparagine RESID-alternate N4-hydroxymethyl-L-asparagine RESID-name N4-hydroxymethylasparagine RESID-alternate DiffAvg 30.03 DiffFormula C 1 H 2 N 0 O 1 DiffMono 30.010565 Formula C 5 H 8 N 2 O 3 MassAvg 144.13 MassMono 144.053492 Origin N Source artifact TermSpec none MOD:00903 PSI-MOD MOD:00242 O-(ADP-ribosyl)-L-serine A protein modification that effectively converts an L-serine residue to O-(ADP-ribosyl)-L-serine. 15842200 PubMed 3141412 PubMed AA0237 RESID 213#S UniMod PSI-MOD-slim (S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-propanoic acid RESID-systematic ADP Ribose addition UniMod-description ADP-Ribosyl PSI-MS-label MOD_RES ADP-ribosylserine UniProt-feature O-(ADP-ribosyl)-L-serine RESID-name O3-(ADP-ribosyl)-L-serine RESID-alternate O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-serine RESID-alternate O3-alpha-D-ribofuranosyl-L-serine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) RESID-alternate OADPRibSer PSI-MOD-label DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 18 H 26 N 6 O 15 P 2 MassAvg 628.38 MassMono 628.093137 Origin S Source natural TermSpec none MOD:00752 MOD:00916 PSI-MOD MOD:00243 L-cysteine oxazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid. 8183941 PubMed 8895467 PubMed AA0238 RESID Cross-link 2. 2-(1-azanyl-2-sulfanylethyl)-4-oxazolecarboxylic acid RESID-alternate 2-[(1R)-1-amino-2-sulfanylethyl]-1,3-oxazole-4-carboxylic acid RESID-systematic CROSSLNK Oxazole-4-carboxylic acid (Cys-Ser) UniProt-feature L-cysteine oxazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 6 H 6 N 2 O 2 S 1 MassAvg 170.19 MassMono 170.014998 Origin C, S Source natural TermSpec none MOD:00905 MOD:01421 MOD:01888 PSI-MOD MOD:00244 L-cysteine oxazoline-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazoline-4-carboxylic acid. 1880060 PubMed AA0239 RESID Cross-link 2. (4S)-2-[(1R)-1-amino-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid RESID-alternate CROSSLNK Oxazoline-4-carboxylic acid (Cys-Ser) UniProt-feature L-cysteine oxazoline-4-carboxylic acid RESID-name DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030649 Origin C, S Source natural TermSpec none MOD:00905 MOD:01421 PSI-MOD MOD:00245 glycine oxazole-4-carboxylic acid A protein modification that effectively crosslinks a glycine residue and an L-serine residue to form glycine oxazole-4-carboxylic acid. 8183941 PubMed 8895467 PubMed AA0240 RESID Cross-link 2. 2-aminomethyl-1,3-oxazole-4-carboxylic acid RESID-systematic 2-azanylmethyl-1,3-oxazole-4-carboxylic acid RESID-alternate CROSSLNK Oxazole-4-carboxylic acid (Gly-Ser) UniProt-feature glycine oxazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 DiffMono -20.026215 Formula C 5 H 4 N 2 O 2 MassAvg 124.10 MassMono 124.027277 Origin G, S Source natural TermSpec none MOD:00908 MOD:01421 MOD:01888 PSI-MOD MOD:00246 glycine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form glycine thiazole-4-carboxylic acid. 21276 ChEBI 8183941 PubMed 8895467 PubMed AA0241 RESID Cross-link 2. 2-(aminomethyl)-1,3-thiazole-4-carboxylic acid RESID-systematic 2-(azanylmethyl)-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Gly-Cys) UniProt-feature glycine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 5 H 4 N 2 O 1 S 1 MassAvg 140.16 MassMono 140.004434 Origin C, G Source natural TermSpec none MOD:00908 MOD:01420 MOD:01888 PSI-MOD MOD:00247 L-serine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-serine thiazole-4-carboxylic acid. 8183941 PubMed 8895467 PubMed AA0242 RESID Cross-link 2. 2-[(1S)-1-amino-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Ser-Cys) UniProt-feature L-serine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 6 H 6 N 2 O 2 S 1 MassAvg 170.19 MassMono 170.014998 Origin C, S Source natural TermSpec none MOD:00916 MOD:01420 MOD:01888 PSI-MOD MOD:00248 L-phenylalanine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazole-4-carboxylic acid. 1880060 PubMed AA0243 RESID Cross-link 2. 2-[(1S)-1-amino-2-phenylethyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-phenylethyl]-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Phe-Cys) UniProt-feature L-phenylalanine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 12 H 10 N 2 O 1 S 1 MassAvg 230.29 MassMono 230.051384 Origin C, F Source natural TermSpec none MOD:00914 MOD:01420 MOD:01888 PSI-MOD MOD:00249 L-cysteine thiazole-4-carboxylic acid A protein modification that effectively crosslinks two L-cysteine residues to form L-cysteine thiazole-4-carboxylic acid. 1880060 PubMed AA0244 RESID Cross-link 2. 2-[(1S)-1-amino-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Cys-Cys) UniProt-feature L-cysteine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 6 H 6 N 2 O 1 S 2 MassAvg 186.25 MassMono 185.992155 Origin C, C Source natural TermSpec none MOD:01420 MOD:01888 PSI-MOD MOD:00250 L-lysine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to form L-lysine thiazole-4-carboxylic acid. 1880060 PubMed AA0245 RESID Cross-link 2. Lysine is now thought not to be encoded in the peptide sequence modified to produce GE2270. See RESID:AA0470. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. 2-[(1S)-1,5-diaminopentyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1,5-bis(azanyl)pentyl]-1,3-thiazole-4-carboxylic acid RESID-alternate L-lysine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 9 H 13 N 3 O 1 S 1 MassAvg 211.28 MassMono 211.077933 Origin C, K Source hypothetical TermSpec none MOD:00912 MOD:01420 MOD:01888 PSI-MOD MOD:00251 O-(phospho-5'-DNA)-L-serine A protein modification that effectively crosslinks an L-serine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-serine. 7142163 PubMed 7265205 PubMed AA0246 RESID (S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)propanoic acid RESID-systematic ACT_SITE O-(5'-phospho-DNA)-serine intermediate UniProt-feature MOD_RES O-(5'-phospho-DNA)-serine UniProt-feature O-(phospho-5'-DNA)-L-serine RESID-name O3-(phospho-5'-DNA)-L-serine RESID-alternate O3-L-serine 5'-DNA phosphodiester RESID-alternate DiffAvg 78.97 DiffFormula C 0 H 0 N 0 O 3 P 1 DiffMono 78.958505 Formula C 3 H 5 N 1 O 5 P 1 MassAvg 166.05 MassMono 165.990534 Origin S Source natural TermSpec none MOD:00750 MOD:00916 PSI-MOD MOD:00252 keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine A protein modification that effectively cross-links an L-threonine residue to the polymer keratan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. 1417734 PubMed 3472204 PubMed AA0247 RESID keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine RESID-name keratosulfate RESID-alternate poly[beta-1,4-(2-acetamido-2-deoxy-6-sulfate D-glucosyl)-beta-1,3-D-galactosyl]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-threonine RESID-systematic DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007825 Formula C 4 H 6 N 1 O 2 MassAvg 100.10 MassMono 100.039853 Origin T Source natural TermSpec none MOD:00005 PSI-MOD MOD:00253 L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Sec) A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide). 14235557 PubMed 2211698 PubMed 8052647 PubMed 9036855 PubMed AA0248#SEC RESID 415 UniMod DiffAvg 1572.02 DiffFormula C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 Se 0 DiffMono 1572.985775 Formula C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1 MassAvg 1722.07 MassMono 1723.939410 Origin U Source natural TermSpec none MOD:00744 MOD:01158 PSI-MOD MOD:00254 O4'-(phospho-5'-RNA)-L-tyrosine A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-tyrosine. 1702164 PubMed 209034 PubMed 217003 PubMed 6264310 PubMed AA0249 RESID (S)-2-amino-3-[4-(5'-ribonucleic acid phosphonoxy)phenyl]propanoic acid RESID-systematic MOD_RES O-(5'-phospho-RNA)-tyrosine UniProt-feature O4'-(phospho-5'-RNA)-L-tyrosine RESID-name O4'-L-tyrosine 5'-RNA phosphodiester RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 9 H 10 N 1 O 5 P 1 MassAvg 243.15 MassMono 243.029659 Origin Y Source natural TermSpec none MOD:00751 MOD:00919 PSI-MOD MOD:00255 3-(3'-L-histidyl)-L-tyrosine A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3-(3'-L-histidyl)-L-tyrosine. 9144772 PubMed AA0250 RESID Cross-link 2. (2S,3R)-2-amino-3-(5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid RESID-systematic 3-(3'-L-histidyl)-L-tyrosine RESID-name 3-(N3'-histidyl)tyrosine RESID-alternate 3-(pi-histidyl)tyrosine RESID-alternate 3-(pros-histidyl)tyrosine RESID-alternate beta-(N(delta)-histidyl)tyrosine RESID-alternate beta-(N3'-histidyl)tyrosine RESID-alternate CROSSLNK 3'-histidyl-3-tyrosine (His-Tyr) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 15 H 14 N 4 O 3 MassAvg 298.30 MassMono 298.106590 Origin H, Y Source natural TermSpec none MOD:00692 MOD:00909 MOD:00919 PSI-MOD MOD:00256 L-methionine sulfone A protein modification that dioxygenates an L-methionine residue to L-methionine sulfone. 205 DeltaMass 12686488 PubMed 7786407 PubMed 7791219 PubMed 9252331 PubMed AA0251 RESID 425#M UniMod DeltaMass gives the formula C 5 H 9 N 3 O 1 S 1 with mass 163 PSI-MOD-slim (2S)-2-amino-4-(methylsulfonyl)butanoic acid RESID-systematic dihydroxy UniMod-description Dioxidation PSI-MS-label L-methionine S,S-dioxide RESID-alternate L-methionine sulfone RESID-name MethionylSulphone DeltaMass-label MetO2 PSI-MOD-label MOD_RES Methionine sulfone UniProt-feature Oxidation of Methionine (to Sulphone) DeltaMass-label S,S-dioxymethionine RESID-alternate suphonem OMSSA-label DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 S 0 DiffMono 31.989829 Formula C 5 H 9 N 1 O 3 S 1 MassAvg 163.19 MassMono 163.030314 Origin M Source natural TermSpec none MOD:00709 MOD:01855 PSI-MOD MOD:00257 dipyrrolylmethanemethyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to dipyrrolylmethanemethyl-L-cysteine. 3042456 PubMed 3196304 PubMed 3421931 PubMed 8727319 PubMed AA0252 RESID 416 UniMod (2S)-3-[5-[4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methyl-4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid RESID-systematic 3-[5-(3-acetic acid-4-propanoic acid-1-pyrrol-2-yl)methyl-3-acetic acid-4-propanoic acid-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid RESID-alternate dipyrrole cofactor RESID-alternate Dipyrrolylmethanemethyl PSI-MS-label dipyrrolylmethanemethyl UniMod-description dipyrrolylmethanemethyl-L-cysteine RESID-name dipyrrolylmethyl-L-cysteine RESID-alternate dipyrromethane cofactor RESID-alternate MOD_RES S-(dipyrrolylmethanemethyl)cysteine UniProt-feature pyrromethane cofactor RESID-alternate DiffAvg 418.40 DiffFormula C 20 H 22 N 2 O 8 S 0 DiffMono 418.137616 Formula C 23 H 27 N 3 O 9 S 1 MassAvg 521.54 MassMono 521.146800 Origin C Source natural TermSpec none MOD:00905 PSI-MOD MOD:00258 S-(2-aminovinyl)-3-methyl-D-cysteine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form S-(2-aminovinyl)-3-methyl-D-cysteine. 9119018 PubMed AA0253 RESID Cross-link 2. (2S,3S)-2-amino-3-[((Z)-2-aminoethenyl)sulfanyl]butanoic acid RESID-systematic 2-amino-3-[(2-aminovinyl)sulfanyl]butanoic acid RESID-alternate CROSSLNK S-(2-aminovinyl)-3-methyl-D-cysteine (Thr-Cys) UniProt-feature decarboxylated methyllanthionine RESID-alternate S-(2-aminovinyl)-3-methyl-D-cysteine RESID-name DiffAvg -64.04 DiffFormula C -1 H -4 N 0 O -3 S 0 DiffMono -64.016044 Formula C 6 H 9 N 2 O 1 S 1 MassAvg 157.21 MassMono 157.043559 Origin C, T Source natural TermSpec C-term MOD:00687 MOD:00917 PSI-MOD MOD:00259 O4'-(phospho-5'-DNA)-L-tyrosine A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of DNA through a phosphodiester bond to form O4'-(phospho-5'-DNA)-L-tyrosine. 1861973 PubMed 2940511 PubMed 3684578 PubMed AA0254 RESID (S)-2-amino-3-[4-(5'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid RESID-systematic ACT_SITE O-(5'-phospho-DNA)-tyrosine intermediate UniProt-feature MOD_RES O-(5'-phospho-DNA)-tyrosine UniProt-feature O4'-(phospho-5'-DNA)-L-tyrosine RESID-name O4'-L-tyrosine 5'-DNA phosphodiester RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 9 H 10 N 1 O 5 P 1 MassAvg 243.15 MassMono 243.029659 Origin Y Source natural TermSpec none MOD:00750 MOD:00919 PSI-MOD MOD:00260 O-(phospho-5'-DNA)-L-threonine A protein modification that effectively crosslinks an L-threonine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-threonine. 3081736 PubMed AA0255 RESID (S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)butanoic acid RESID-systematic O-(phospho-5'-DNA)-L-threonine RESID-name O3-(phospho-5'-DNA)-L-threonine RESID-alternate O3-L-threonine 5'-DNA phosphodiester RESID-alternate DiffAvg 78.97 DiffFormula C 0 H 0 N 0 O 3 P 1 DiffMono 78.958505 Formula C 4 H 7 N 1 O 5 P 1 MassAvg 180.08 MassMono 180.006184 Origin T Source natural TermSpec none MOD:00750 MOD:00917 PSI-MOD MOD:00261 O4'-(phospho-5'-uridine)-L-tyrosine A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphouridine through a phosphodiester bond to form O4'-(phospho-5'-uridine)-L-tyrosine. 0 DeltaMass 11467524 PubMed 2885322 PubMed AA0256 RESID 417#Y UniMod From DeltaMass: Average Mass: 306. PSI-MOD-slim (S)-2-amino-3-[4-(5'-uridine phosphonoxy)phenyl]propanoic acid RESID-systematic 5'-uridylic-O-tyrosine RESID-alternate hydrogen 5'-uridylate tyrosine ester RESID-alternate MOD_RES O-UMP-tyrosine UniProt-feature O-Uridinylylation (of Tyrosine) DeltaMass-label O4'-(phospho-5'-uridine)-L-tyrosine RESID-name O4'-L-tyrosine 5'-uridine phosphodiester RESID-alternate OUMPTyr PSI-MOD-label PhosphoUridine PSI-MS-label uridine phosphodiester UniMod-description DiffAvg 306.17 DiffFormula C 9 H 11 N 2 O 8 P 1 DiffMono 306.025302 Formula C 18 H 20 N 3 O 10 P 1 MassAvg 469.34 MassMono 469.088630 Origin Y Source natural TermSpec none MOD:00919 MOD:01166 PSI-MOD MOD:00262 N-(L-glutamyl)-L-tyrosine A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and a free L-tyrosine. 21477 ChEBI 6387372 PubMed 8093886 PubMed AA0257 RESID Cross-link 2. (S,S)-2-(2-aminopentanedio-1-yl)amino-3-(4-hydoxyphenyl)propanoic acid RESID-systematic L-glutamyl L-tyrosine RESID-name N-(L-glutamyl)-L-tyrosine RESID-alternate SITE Involved in polymerization UniProt-feature DiffAvg -17.01 DiffFormula C 0 H -1 N 0 O -1 DiffMono -17.002740 Formula C 14 H 16 N 2 O 5 MassAvg 292.29 MassMono 292.105922 Origin E, Y Source natural TermSpec C-term MOD:00906 MOD:00919 PSI-MOD MOD:00263 S-phycoviolobilin-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoviolobilin. 2106585 PubMed 3208761 PubMed AA0258 RESID 387 UniMod (4S)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-4,5-dihydro-2,7,13,17-tetramethyl-(21H,22H,24H)-biladiene-bc-1,19-dione RESID-systematic BINDING Phycoviolobilin chromophore (covalent; via 1 link) UniProt-feature cryptobiliviolin RESID-alternate cryptoviolin RESID-alternate cryptoviolobilin RESID-alternate PBV RESID-alternate Phycocyanobilin PSI-MS-label phycocyanobilin UniMod-description PVB RESID-alternate PXB RESID-alternate S-phycobiliviolin-L-cysteine RESID-alternate S-phycoviolobilin-L-cysteine RESID-name DiffAvg 586.69 DiffFormula C 33 H 38 N 4 O 6 S 0 DiffMono 586.279135 Formula C 36 H 43 N 5 O 7 S 1 MassAvg 689.83 MassMono 689.288320 Origin C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00264 phycoerythrobilin-bis-L-cysteine A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycoerythrobilin. 3208761 PubMed 3838747 PubMed AA0259 RESID Cross-link 2. (2S,3R,16R)-3,18-bis-[(R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione RESID-systematic 3,18-bis-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-biladiene-ab-8,12-dipropanoic acid RESID-alternate BINDING Phycoerythrobilin chromophore (covalent; via 2 links) UniProt-feature PEB RESID-alternate phycoerythrobilin biscysteine adduct RESID-alternate phycoerythrobilin-bis-L-cysteine RESID-name DiffAvg 586.69 DiffFormula C 33 H 38 N 4 O 6 S 0 DiffMono 586.279135 Formula C 39 H 48 N 6 O 8 S 2 MassAvg 792.97 MassMono 792.297505 Origin C, C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00265 phycourobilin-bis-L-cysteine A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycourobilin. 3208761 PubMed 3838665 PubMed 3838747 PubMed 8876649 PubMed AA0260 RESID Cross-link 2. 3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-2,7,13,17-tetramethyl-1,19-dioxo-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-8,12-dipropanoic acid RESID-alternate 3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-1,19(4H,16H)-dione RESID-systematic BINDING Phycourobilin chromophore (covalent; via 2 links) UniProt-feature phycourobilin biscysteine adduct RESID-alternate phycourobilin-bis-L-cysteine RESID-name PUB RESID-alternate DiffAvg 586.69 DiffFormula C 33 H 38 N 4 O 6 S 0 DiffMono 586.279135 Formula C 39 H 48 N 6 O 8 S 2 MassAvg 792.97 MassMono 792.297505 Origin C, C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:00266 N-L-glutamyl-poly-L-glutamic acid A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and one or more free L-glutamic acid molecules to form N-(L-glutamyl)-poly-L-glutamic acid. 2570347 PubMed 328274 PubMed AA0261 RESID DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 10 H 15 N 2 O 7 MassAvg 275.24 MassMono 275.087926 Origin E Source natural TermSpec C-term MOD:00906 PSI-MOD MOD:00267 L-cysteine sulfinic acid A protein modification that effectively dioxygenates an L-cysteine residue to L-cysteine sulfinic acid. 16345 ChEBI 12686488 PubMed 9252331 PubMed 9586994 PubMed AA0262 RESID 425#C UniMod "Hyun Ae Woo, et. al., Science 300 (5619), 653-656" PSI-MOD-slim (2R)-2-amino-3-sulfinopropanoic acid RESID-systematic 2-amino-2-carboxyethanesulfinic acid RESID-alternate 2-amino-3-(dioxido-lambda(6)-sulfanyl)propanoic acid [tautomer] RESID-alternate 2-amino-3-sulfonylpropanoic acid [tautomer] RESID-alternate 3-sulfinoalanine RESID-alternate 3-sulphinoalanine RESID-alternate CysO2H PSI-MOD-label cysteine sulphinic acid RESID-alternate cysteine-S,S-dioxide [tautomer] RESID-alternate dihydroxy UniMod-description Dioxidation PSI-MS-label L-cysteine sulfinic acid RESID-name MOD_RES Cysteine sulfinic acid (-SO2H) UniProt-feature S-cysteinesulfinic acid RESID-alternate S-sulfinocysteine RESID-alternate sulfinicacid OMSSA-label DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 S 0 DiffMono 31.989829 Formula C 3 H 5 N 1 O 3 S 1 MassAvg 135.14 MassMono 134.999014 Origin C Source natural TermSpec none MOD:00708 MOD:01855 PSI-MOD MOD:00268 L-3',4',5'-trihydroxyphenylalanine A protein modification that effectively converts an L-tyrosine residue to L-3',4',5'-trihydroxyphenylalanine. 0 DeltaMass 12686488 PubMed 12771378 PubMed 8554314 PubMed 9252331 PubMed 9434739 PubMed AA0263 RESID 425#Y UniMod From DeltaMass: Average Mass: 32 (S)-2-amino-3-(3,4,5-trihydroxyphenyl)propanoic acid RESID-systematic 3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA) DeltaMass-label 35Hy2Tyr PSI-MOD-label dihydroxy UniMod-description Dioxidation PSI-MS-label L-3',4',5'-trihydroxyphenylalanine RESID-name L-3,4,5-TOPA RESID-alternate DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 9 H 9 N 1 O 4 MassAvg 195.17 MassMono 195.053158 Origin Y Source natural TermSpec none MOD:00428 MOD:00707 PSI-MOD MOD:00269 O-(sn-1-glycerophosphoryl)-L-serine A protein modification that effectively converts an L-serine residue to O-(sn-1-glycerophosphoryl)-L-serine. 8645220 PubMed AA0264 RESID 419#S UniMod PSI-MOD-slim (2S)-2-amino-3-[(2Xi)-2,3-dihydroxypropyl]phosphonoxypropanoic acid RESID-systematic alpha-glycerophosphoryl serine RESID-alternate Glycerophospho PSI-MS-label glycerophospho UniMod-description glycerophosphoserine RESID-alternate MOD_RES O-(sn-1-glycerophosphoryl)serine UniProt-feature O-(sn-1-glycerophosphoryl)-L-serine RESID-name O3-(sn-1-glycerophosphoryl)-L-serine RESID-alternate O3-2,3-dihydroxypropyl hydrogen phosphate-L-serine ester RESID-alternate O3-L-serine glyceryl-1-phosphodiester RESID-alternate DiffAvg 154.06 DiffFormula C 3 H 7 N 0 O 5 P 1 DiffMono 154.003110 Formula C 6 H 12 N 1 O 7 P 1 MassAvg 241.14 MassMono 241.035138 Origin S Source natural TermSpec none MOD:00916 PSI-MOD MOD:00270 1-thioglycine (internal) A protein modification that effectively converts a glycine residue to an internal 1-thioglycine. 11463785 PubMed 9367957 PubMed AA0265#INT RESID This modification occurs naturally in two forms. At an interior peptide location it exists as aminoethanethionic acid (or aminoethanethioic O-acid). At the carboxyl-terminal it exists as aminoethanethiolic acid (or aminoethanethioic S-acid). PSI-MOD-slim 1-thioglycine RESID-name 2-amino-1-sulfanylethanone RESID-alternate aminoethanethioic acid RESID-systematic aminoethanethioic O-acid RESID-alternate aminoethanethionic acid RESID-alternate aminothioacetic acid RESID-alternate Carboxy->Thiocarboxy PSI-MS-label MOD_RES 1-thioglycine UniProt-feature S(O)Gly PSI-MOD-label thiocarboxylic acid UniMod-description DiffAvg 16.06 DiffFormula C 0 H 0 N 0 O -1 S 1 DiffMono 15.977156 Formula C 2 H 3 N 1 S 1 MassAvg 73.11 MassMono 72.998620 Origin G Source natural TermSpec none MOD:01625 PSI-MOD MOD:00271 heme P460-bis-L-cysteine-L-tyrosine A protein modification that effectively results from forming an adduct between two cysteine residues, the C-3' of a tyrosine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 8325841 PubMed 9095195 PubMed AA0266 RESID Cross-link 3. (10S,11S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-10-(2-hydroxy-5-[(S)-2-amino-2-carboxy]ethylphenyl)-3,8,13,17-tetramethyl-21H,23H-10,11-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate RESID-systematic BINDING Heme (covalent; via 3 links) UniProt-feature bis(S-cysteinyl)-(tyros-3'-yl)-heme RESID-alternate heme P460-bis-L-cysteine-L-tyrosine RESID-name DiffAvg 614.48 DiffFormula C 34 Fe 1 H 30 N 4 O 4 S 0 DiffMono 614.161643 Formula C 49 Fe 1 H 49 N 7 O 8 S 2 MassAvg 983.94 MassMono 983.243341 Origin C, C, Y Source natural TermSpec none MOD:00699 MOD:00905 MOD:00919 PSI-MOD MOD:00272 O-(phospho-5'-adenosine)-L-threonine A protein modification that effectively crosslinks an L-threonine residue and 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-threonine. 2989287 PubMed 8917428 PubMed AA0267 RESID 405#T UniMod PSI-MOD-slim (2S,3R)-2-amino-3-(5'-adenosine phosphonoxy)butanoic acid RESID-systematic 5'-adenylic-O3-L-threonine RESID-alternate ACT_SITE O-AMP-threonine intermediate UniProt-feature AMP binding site UniMod-description beta-5'-adenylic-L-threonine RESID-alternate L-threonine monoanhydride with 5'-adenylic acid RESID-alternate MOD_RES O-AMP-threonine UniProt-feature O(gamma)-5'-adenylic-L-threonine RESID-alternate O-(phospho-5'-adenosine)-L-threonine RESID-name O3-(phospho-5'-adenosine)-L-threonine RESID-alternate O3-L-threonine 5'-adenosine phosphodiester RESID-alternate Phosphoadenosine PSI-MS-label DiffAvg 329.21 DiffFormula C 10 H 12 N 5 O 6 P 1 DiffMono 329.052520 Formula C 14 H 19 N 6 O 8 P 1 MassAvg 430.31 MassMono 430.100198 Origin T Source natural TermSpec none MOD:00917 MOD:01165 PSI-MOD MOD:00273 tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a four-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide. 12764602 PubMed AA0268 RESID Cross-link 7; secondary to RESID:AA0269. 4Fe-2S-3O cluster RESID-alternate hybrid four iron cluster 2 RESID-alternate METAL Iron-oxo-sulfur (4Fe-2O-2S) UniProt-feature METAL Iron-oxo-sulfur (4Fe-2O-2S); via persulfide group UniProt-feature METAL Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogen UniProt-feature mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-iron-3,4-bis-(S-cysteinyl iron) RESID-systematic prismane iron-sulfur cofactor RESID-misnomer tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide RESID-name DiffAvg 360.50 DiffFormula C 0 Fe 4 H -7 N 0 O 3 S 3 DiffMono 360.585932 Formula C 28 Fe 4 H 34 N 9 O 14 S 7 MassAvg 1168.43 MassMono 1167.766769 Origin C, C, C, C, E, E, H Source natural TermSpec none MOD:00739 MOD:00905 MOD:00906 MOD:00909 PSI-MOD MOD:00274 L-cysteine persulfide A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a sulfanyl group, forming a disulfanyl group, and converting an L-cysteine residue to L-cysteine persulfide. 28839 ChEBI 15096637 PubMed 4276457 PubMed 8161529 PubMed AA0269 RESID 421 UniMod PSI-MOD-slim (R)-2-amino-3-disulfanylpropanoic acid RESID-systematic 2-amino-3-disulfanylpropanoic acid RESID-alternate 2-amino-3-hydrodisulfidopropanoic acid RESID-alternate 2-amino-3-hydropersulfidopropanoic acid RESID-alternate 2-amino-3-persulfhydrylpropanoic acid RESID-alternate 3-(thiosulfeno)-alanine RESID-alternate 3-disulfanylalanine RESID-alternate ACT_SITE Cysteine persulfide intermediate UniProt-feature L-cysteine persulfide RESID-name MOD_RES Cysteine persulfide UniProt-feature persulfide UniMod-description S-mercaptocysteine RESID-alternate S-sulfanylcysteine RESID-alternate Sulfide PSI-MS-label thiocysteine RESID-alternate DiffAvg 32.06 DiffFormula C 0 H 0 N 0 O 0 S 1 DiffMono 31.972071 Formula C 3 H 5 N 1 O 1 S 2 MassAvg 135.20 MassMono 134.981256 Origin C Source natural TermSpec none MOD:00905 MOD:01886 PSI-MOD MOD:00275 3'-(1'-L-histidyl)-L-tyrosine A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3'-(1'-L-histidyl)-L-tyrosine. 19837 ChEBI 10338009 PubMed AA0270 RESID Cross-link 2. PSI-MOD-slim (2S)-2-amino-3-[1-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenyl)-1H-imidazol-4-yl]propanoic acid RESID-systematic 3'-(1'-L-histidyl)-L-tyrosine RESID-name 3'-(N(epsilon)-histidyl)tyrosine RESID-alternate 3'-(N1'-histidyl)tyrosine RESID-alternate 3'-(tau-histidyl)tyrosine RESID-alternate 3'-(tele-histidyl)tyrosine RESID-alternate CROSSLNK 1'-histidyl-3'-tyrosine (His-Tyr) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 15 H 14 N 4 O 3 MassAvg 298.30 MassMono 298.106590 Origin H, Y Source natural TermSpec none MOD:00692 MOD:00909 MOD:00919 PSI-MOD MOD:00276 heme P460-bis-L-cysteine-L-lysine A protein modification that effectively results from forming an adduct between two cysteine residues, a lysine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 12709052 PubMed 9237682 PubMed AA0271 RESID Cross-link 3. (19S,20S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-20-([(S)-5-amino-5-carboxypentyl]amino)-3,8,13,17-tetramethyl-21H,23H-19,20-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate RESID-systematic BINDING Heme (covalent; via 3 links) UniProt-feature bis(S-cysteinyl)-N6-lysino-heme RESID-alternate heme P460-bis-L-cysteine-L-lysine RESID-name DiffAvg 614.48 DiffFormula C 34 Fe 1 H 30 N 4 O 4 S 0 DiffMono 614.161643 Formula C 46 Fe 1 H 52 N 8 O 7 S 2 MassAvg 948.94 MassMono 948.274976 Origin C, C, K Source natural TermSpec none MOD:00699 MOD:00905 MOD:00912 PSI-MOD MOD:00277 5-methyl-L-arginine A protein modification that effectively converts an L-arginine residue to 5-methyl-L-arginine. 10660523 PubMed 11875433 PubMed 9367957 PubMed AA0272 RESID (2S,5S)-2-amino-5-carbamimidamidohexanoic acid RESID-systematic 2-amino-5-guanidinohexanoic acid RESID-alternate 4-methylarginine RESID-misnomer 5-methyl-L-arginine RESID-name 5-methylated L-arginine PSI-MOD-alternate C5Me1Arg PSI-MOD-label delta-methylarginine RESID-alternate Methyl PSI-MS-label Methylation UniMod-description MOD_RES 5-methylarginine UniProt-feature DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 14 N 4 O 1 MassAvg 170.22 MassMono 170.116761 Origin R Source natural TermSpec none MOD:00414 MOD:00656 PSI-MOD MOD:00278 2-methyl-L-glutamine A protein modification that effectively converts an L-glutamine residue to 2-methyl-L-glutamine. 10660523 PubMed 11875433 PubMed 9367957 PubMed AA0273 RESID (S)-2-amino-2-methylpentanediamic acid RESID-systematic 2-methyl-L-glutamine RESID-name 2-methylated L-glutamine PSI-MOD-alternate 2-methylglutamine RESID-alternate alpha-methylglutamine RESID-alternate C2MeGln PSI-MOD-label Methyl PSI-MS-label Methylation UniMod-description MOD_RES 2-methylglutamine UniProt-feature DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 6 H 10 N 2 O 2 MassAvg 142.16 MassMono 142.074228 Origin Q Source natural TermSpec none MOD:00656 MOD:00722 PSI-MOD MOD:00279 N-pyruvic acid 2-iminyl-L-cysteine A protein modification that effectively converts an Lcysteline residue to N-pyruvic acid 2-iminyl-L-cysteine. 1388164 PubMed AA0274 RESID 422#C UniMod PSI-MOD-slim (R)-2-(1-carboxy-2-sulfanylethanimino)propanoic acid RESID-systematic MOD_RES N-pyruvate 2-iminyl-cysteine UniProt-feature N-pyruvic acid 2-iminyl UniMod-description N-pyruvic acid 2-iminyl-L-cysteine RESID-name PyruvicAcidIminyl PSI-MS-label DiffAvg 70.05 DiffFormula C 3 H 2 N 0 O 2 S 0 DiffMono 70.005479 Formula C 6 H 8 N 1 O 3 S 1 MassAvg 174.19 MassMono 174.022489 Origin C Source natural TermSpec N-term MOD:00905 MOD:01170 PSI-MOD MOD:00280 N-pyruvic acid 2-iminyl-L-valine A protein modification that effectively converts an L-valine residue to N-pyruvic acid 2-iminyl-L-valine. 2071591 PubMed AA0275 RESID 422#V UniMod PSI-MOD-slim (S)-2-(1-carboxy-2-methylpropanimino)propanoic acid RESID-systematic MOD_RES N-pyruvate 2-iminyl-valine UniProt-feature N-pyruvic acid 2-iminyl UniMod-description N-pyruvic acid 2-iminyl-L-valine RESID-name PyruvicAcidIminyl PSI-MS-label DiffAvg 70.05 DiffFormula C 3 H 2 N 0 O 2 DiffMono 70.005479 Formula C 8 H 12 N 1 O 3 MassAvg 170.19 MassMono 170.081718 Origin V Source natural TermSpec N-term MOD:00920 MOD:01170 PSI-MOD MOD:00281 3'-heme-L-histidine A protein modification that effectively results from forming an adduct between the pros nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 12119398 PubMed 12429096 PubMed 12486054 PubMed 9712585 PubMed AA0276 RESID 2-[1-(N3'-histidyl)ethyl]protoporphyrin IX RESID-alternate 3'-heme-L-histidine RESID-name [7-ethenyl-12-((S)-1-[((R)-2-amino-2-carboxyethyl)-3H-imidazol-3-yl]ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate RESID-systematic BINDING Heme (covalent; via pros nitrogen) UniProt-feature N(delta)-histidyl heme RESID-alternate N(pi)-histidyl heme RESID-alternate N3'-histidyl heme RESID-alternate pros-histidyl heme RESID-alternate DiffAvg 616.50 DiffFormula C 34 Fe 1 H 32 N 4 O 4 DiffMono 616.177293 Formula C 40 Fe 1 H 39 N 7 O 5 MassAvg 753.64 MassMono 753.236205 Origin H Source natural TermSpec none MOD:00699 MOD:00909 PSI-MOD MOD:00282 S-selenyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-selenyl-L-cysteine. 10430865 PubMed 10966817 PubMed 11827487 PubMed 12716131 PubMed 14594807 PubMed AA0277 RESID 423#C UniMod (R)-2-amino-3-(selanylsulfanyl)propanoic acid RESID-systematic 2-amino-3-hydroselenosulfidopropanoic acid RESID-alternate 2-amino-3-hydroselenylsulfidopropanoic acid RESID-alternate 2-amino-3-hydroselenylthiopropanoic acid RESID-alternate ACT_SITE S-selanylcysteine intermediate UniProt-feature cysteine perselenide RESID-misnomer Delta:Se(1) PSI-MS-label MOD_RES S-selanylcysteine UniProt-feature S-selanyl-L-cysteine RESID-name S-selanylcysteine RESID-alternate S-selenylcysteine RESID-alternate selenyl UniMod-description DiffAvg 78.97 DiffFormula C 0 H 0 N 0 O 0 S 0 Se 1 DiffMono 79.916521 Formula C 3 H 5 N 1 O 1 S 1 Se 1 MassAvg 182.11 MassMono 182.925706 Origin C Source hypothetical TermSpec none MOD:00745 MOD:00778 MOD:00905 PSI-MOD MOD:00283 N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine A protein modification that effectively converts an L-lysine residue to an N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine. 10550045 PubMed 11349130 PubMed AA0278 RESID (alpha)- ([([(5S)-5-amino-5-carboxypentyl]amino)propyl][(methyl)amino])-(omega)-methyl poly[propane-1,3-diyl(methylimino)] RESID-systematic lysine derivative Lys(x) RESID-alternate MOD_RES N6-poly(methylaminopropyl)lysine UniProt-feature N6-[3-([(omega)-(dimethyl)aminopropyl-poly(3-[methylamino]propyl)]amino)propyl]lysine RESID-alternate N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine RESID-name silaffin polycationic lysine derivative RESID-alternate DiffAvg 426.74 DiffFormula C 24 H 54 N 6 O 0 DiffMono 426.440996 Formula C 30 H 66 N 8 O 1 MassAvg 554.91 MassMono 554.535959 Origin K Source natural TermSpec none MOD:00912 PSI-MOD MOD:00284 dihydroxyheme-L-aspartate ester-L-glutamate ester A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 10447690 PubMed AA0279 RESID Cross-link 2. 1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester RESID-alternate [13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-7,12-diethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate RESID-systematic BINDING Heme (covalent; via 2 links) UniProt-feature dihydroxyheme-L-aspartate ester-L-glutamate ester RESID-name peroxidase heme cofactor RESID-alternate DiffAvg 612.47 DiffFormula C 34 Fe 1 H 28 N 4 O 4 DiffMono 612.145993 Formula C 43 Fe 1 H 40 N 6 O 10 MassAvg 856.67 MassMono 856.215529 Origin D, E Source hypothetical TermSpec none MOD:00699 MOD:00904 MOD:00906 PSI-MOD MOD:00285 dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, a methionine residue (forming a sulfonium ether), and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 10447690 PubMed 10480885 PubMed 1320128 PubMed 7840679 PubMed AA0280 RESID Cross-link 3. 1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester 2-methionine sulfonium RESID-alternate [13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-12-[(S)-(3-amino-3-carboxy)propylsulfoniumethyl]-7-ethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate RESID-systematic BINDING Heme (covalent; via 3 links) UniProt-feature dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium RESID-name myeloperoxidase heme cofactor RESID-alternate DiffAvg 613.47 DiffFormula C 34 Fe 1 H 29 N 4 O 4 S 0 DiffMono 613.153269 FormalCharge 1+ Formula C 48 Fe 1 H 50 N 7 O 11 S 1 MassAvg 988.87 MassMono 988.263290 Origin D, E, M Source natural TermSpec none MOD:00699 MOD:00904 MOD:00906 MOD:00913 PSI-MOD MOD:00286 L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide). AA0281 RESID 424#C UniMod 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide RESID-alternate bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-cystein-S-yl-molybdenum RESID-systematic L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) RESID-name molybdenum bis(molybdopterin guanine dinucleotide) UniMod-description MolybdopterinGD PSI-MS-label DiffAvg 1572.02 DiffFormula C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 DiffMono 1572.985775 Formula C 43 H 52 Mo 1 N 21 O 27 P 4 S 5 MassAvg 1675.15 MassMono 1675.994960 Origin C Source hypothetical TermSpec none MOD:00905 MOD:01167 PSI-MOD MOD:00287 (2S,3R,4S)-3,4-dihydroxyproline A protein modification that effectively converts an L-proline residue to a (2S,3R,4S)-3,4-dihydroxyproline. 0 DeltaMass 12686488 PubMed AA0282 RESID 425#P UniMod From DeltaMass: Average Mass: 32. (2S,3R,4S)-3,4-dihydroxyproline RESID-name (2S,3R,4S)-3,4-dihydroxypyrrolidine-2-carboxylic acid RESID-systematic 2,3-trans-3,4-cis-3,4-dihydroxy-L-proline RESID-alternate 2-alpha-3-beta-4-beta-3,4-dihydroxyproline RESID-alternate 3,4-dihydroxylated L-proline PSI-MOD-alternate 3,4-Dihydroxylation (of Proline) DeltaMass-label 34Hy2Pro PSI-MOD-label dihydroxy UniMod-description Dioxidation PSI-MS-label MOD_RES (3R,4S)-3,4-dihydroxyproline UniProt-feature trans-2,3-cis-3,4-dihydroxy-L-proline RESID-alternate DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin P Source natural TermSpec none MOD:00866 PSI-MOD MOD:00288 pyrroloquinoline quinone A protein modification that effectively doubly cross-links an L-glutamic acid residue and an L-tyrosine residue with a carbon-carbon bond and a carbon-nitrogen bond to form pyrroloquinoline quinone. 18315 ChEBI 1310505 PubMed 7665488 PubMed AA0283 RESID Cross-link 2. 2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinone RESID-alternate 2,7,9-tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dione RESID-alternate 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-5,6]quinoline-2,7,9-tricarboxylic acid RESID-systematic coenzyme PQQ RESID-alternate CROSSLNK Pyrroloquinoline quinone (Glu-Tyr) UniProt-feature methoxatin RESID-alternate pyrroloquinoline quinone RESID-name DiffAvg 37.92 DiffFormula C 0 H -10 N 0 O 3 DiffMono 37.906494 Formula C 14 H 6 N 2 O 8 MassAvg 330.21 MassMono 330.012415 Origin E, Y Source natural TermSpec none MOD:00692 MOD:00906 MOD:00919 PSI-MOD MOD:00289 tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide. 9836629 PubMed AA0284 RESID Cross-link 4. METAL Iron-sulfur (4Fe-4S) UniProt-feature METAL Iron-sulfur (4Fe-4S); via tele nitrogen UniProt-feature tetra-mu3-sulfidotris(S-cysteinyliron)(N1'-histidinoiron) RESID-systematic tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide RESID-name DiffAvg 347.59 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.597831 FormalCharge 2- Formula C 15 Fe 4 H 18 N 6 O 4 S 7 MassAvg 794.15 MassMono 793.684297 Origin C, C, C, H Source natural TermSpec none MOD:00739 MOD:00905 MOD:00909 PSI-MOD MOD:00290 tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide. 7854413 PubMed AA0285 RESID Cross-link 4. METAL Iron-sulfur (4Fe-4S) UniProt-feature METAL Iron-sulfur (4Fe-4S); via pros nitrogen UniProt-feature tetra-mu3-sulfidotris(S-cysteinyliron)(N3'-histidinoiron) RESID-systematic tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide RESID-name DiffAvg 347.59 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.597831 FormalCharge 2- Formula C 15 Fe 4 H 18 N 6 O 4 S 7 MassAvg 794.15 MassMono 793.684297 Origin C, C, C, H Source natural TermSpec none MOD:00739 MOD:00905 MOD:00909 PSI-MOD MOD:00291 tris-L-cysteinyl L-aspartato tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-aspartato tetrairon tetrasulfide. 7819255 PubMed 9283079 PubMed AA0286 RESID Cross-link 4. METAL Iron-sulfur (4Fe-4S) UniProt-feature tetra-mu3-sulfidotris(S-cysteinyliron)(O4-aspartatoiron) RESID-systematic tris-L-cysteinyl L-aspartato tetrairon tetrasulfide RESID-name DiffAvg 347.59 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.597831 FormalCharge 2- Formula C 13 Fe 4 H 16 N 4 O 6 S 7 MassAvg 772.09 MassMono 771.652328 Origin C, C, C, D Source natural TermSpec none MOD:00739 MOD:00904 MOD:00905 PSI-MOD MOD:00292 N6-pyruvic acid 2-iminyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-pyruvic acid 2-iminyl-L-lysine. 1463470 PubMed 7853400 PubMed 9047371 PubMed AA0287 RESID 422#K UniMod (2S)-2-amino-6-([1-carboxyethylidene]amino)hexanoic acid RESID-systematic ACT_SITE Schiff-base intermediate with substrate UniProt-feature N-pyruvic acid 2-iminyl UniMod-description N6-pyruvic acid 2-iminyl-L-lysine RESID-name PyruvicAcidIminyl PSI-MS-label DiffAvg 70.05 DiffFormula C 3 H 2 N 0 O 2 DiffMono 70.005479 Formula C 9 H 14 N 2 O 3 MassAvg 198.22 MassMono 198.100442 Origin K Source natural TermSpec none MOD:00912 MOD:01170 PSI-MOD MOD:00293 tris-L-cysteinyl L-serinyl tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-serine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-serinyl tetrairon tetrasulfide. AA0288 RESID Cross-link 4. tetra-mu3-sulfidotris(S-cysteinyliron)(O3-serinyliron) RESID-systematic tris-L-cysteinyl L-serinyl tetrairon tetrasulfide RESID-name DiffAvg 347.59 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.597831 FormalCharge 2- Formula C 12 Fe 4 H 16 N 4 O 5 S 7 MassAvg 744.08 MassMono 743.657414 Origin C, C, C, S Source hypothetical TermSpec none MOD:00739 MOD:00905 MOD:00916 PSI-MOD MOD:00294 bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide A protein modification that effectively converts two L-cysteine residues, an L-histidine residues, an L-serine residue and a four-iron four-sulfur cluster to bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide. AA0289 RESID Cross-link 4. bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide RESID-name METAL Iron-sulfur (4Fe-4S) UniProt-feature METAL Iron-sulfur (4Fe-4S); via pros nitrogen UniProt-feature tetra-mu3-sulfidobis(S-cysteinyliron)(N3'-histidinoiron)(O3-serinyliron) RESID-systematic DiffAvg 347.59 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.597831 FormalCharge 2- Formula C 15 Fe 4 H 18 N 6 O 5 S 6 MassAvg 778.09 MassMono 777.707141 Origin C, C, H, S Source hypothetical TermSpec none MOD:00739 MOD:00905 MOD:00909 MOD:00916 PSI-MOD MOD:00295 O-octanoyl-L-serine A protein modification that effectively converts an L-serine residue to O-octanoyl-L-serine. 10604470 PubMed 12716131 PubMed AA0290 RESID 426#S UniMod PSI-MOD-slim (2S)-2-amino-3-(octanoyloxy)propanoic acid RESID-systematic L-serine octanoate ester RESID-alternate LIPID O-octanoyl serine UniProt-feature O-octanoyl-L-serine RESID-name O-octanoylated L-serine PSI-MOD-alternate O3-octanoyl-L-serine RESID-alternate Octanoyl PSI-MS-label octanoyl UniMod-description OOctSer PSI-MOD-label DiffAvg 126.20 DiffFormula C 8 H 14 N 0 O 1 DiffMono 126.104465 Formula C 11 H 19 N 1 O 3 MassAvg 213.28 MassMono 213.136493 Origin S Source natural TermSpec none MOD:00669 MOD:00916 PSI-MOD MOD:00296 O-D-glucuronosyl-L-serine A protein modification that effectively converts an L-serine residue to O-D-glucuronosyl-L-serine. 10858503 PubMed 12716131 PubMed 7398618 PubMed AA0291 RESID 54#S UniMod PSI-MOD-slim (2S)-2-amino-3-(beta-D-glucopyranuronosyl)propanoic acid RESID-systematic CARBOHYD O-linked (GlcA) UniProt-feature Glucuronyl PSI-MS-label N-glucuronylation UniMod-description O-D-glucuronosyl-L-serine RESID-name O3-D-glucuronosyl-L-serine RESID-alternate DiffAvg 176.12 DiffFormula C 6 H 8 N 0 O 6 DiffMono 176.032088 Formula C 9 H 13 N 1 O 8 MassAvg 263.20 MassMono 263.064116 Origin S Source natural TermSpec none MOD:00447 MOD:00916 PSI-MOD MOD:00297 tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. AA0292 RESID Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. carbon monoxide dehydrogenase nickel-iron cofactor RESID-alternate hybrid nickel-triiron cluster RESID-alternate mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-nickel-3,4-bis-(S-cysteinyl iron) RESID-systematic Ni-3Fe-2S-3O cluster RESID-alternate tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide RESID-name DiffAvg 363.35 DiffFormula C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3 DiffMono 362.586337 Formula C 28 Fe 3 H 34 N 9 Ni 1 O 14 S 7 MassAvg 1171.28 MassMono 1169.767174 Origin C, C, C, C, E, E, H Source artifact TermSpec none MOD:00739 MOD:00741 MOD:00905 MOD:00906 MOD:00909 PSI-MOD MOD:00298 tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide A protein modification that effectively converts four L-cysteine residues, an L-glutamic acid residue, an L-histidine residue, an L-serine residue and a one-nickel three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. 2550436 PubMed AA0293 RESID Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. carbon monoxide dehydrogenase nickel-iron cofactor RESID-alternate hybrid nickel-triiron cluster RESID-alternate mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O3-serinyl 2-nickel-3,4-bis-(S-cysteinyl iron) RESID-systematic Ni-3Fe-2S-3O cluster RESID-alternate tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide RESID-name DiffAvg 363.35 DiffFormula C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3 DiffMono 362.586337 Formula C 26 Fe 3 H 32 N 9 Ni 1 O 13 S 7 MassAvg 1129.24 MassMono 1127.756609 Origin C, C, C, C, E, H, S Source artifact TermSpec none MOD:00739 MOD:00741 MOD:00905 MOD:00906 MOD:00909 MOD:00916 PSI-MOD MOD:00299 N6-(L-isoaspartyl)-L-lysine (Asn) A protein modification that effectively crosslinks an L-asparagine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of ammonia. 21862 ChEBI 0 DeltaMass 11000116 PubMed 6503713 PubMed AA0294 RESID Cross-link 2. (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid RESID-systematic beta-(N6-lysyl)aspartyl acid RESID-alternate CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) UniProt-feature isoaspartyl N6-lysine RESID-alternate N(epsilon)-(beta-aspartyl)lysine RESID-alternate N-(beta-Aspartyl)-Lysine (Crosslink) DeltaMass-label N6-(L-isoaspartyl)-L-lysine RESID-name XLNK-4Asp-N6Lys(Asn) PSI-MOD-label DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 10 H 15 N 3 O 3 MassAvg 225.25 MassMono 225.111341 Origin K, N Source natural TermSpec none MOD:00903 MOD:00946 MOD:01929 PSI-MOD MOD:00300 L-glutamyl-5-poly(ADP-ribose) A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose). 0 DeltaMass 11246023 PubMed 15842200 PubMed 8533153 PubMed AA0295 RESID 213#E UniMod (S)-2-amino-5-poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl]oxy-5-oxopentanoic acid RESID-systematic ADP Ribose addition UniMod-description ADP-Ribosyl PSI-MS-label L-glutamyl-5-poly(ADP-ribose) RESID-name L-isoglutamyl-poly(ADP-ribose) RESID-alternate MOD_RES PolyADP-ribosyl glutamic acid UniProt-feature O-ADP-ribosylation (on Glutamate or C terminus) DeltaMass-label DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 20 H 28 N 6 O 16 P 2 MassAvg 670.42 MassMono 670.103702 Origin E Source natural TermSpec none MOD:00752 MOD:00906 PSI-MOD MOD:00301 O-(N-acetylglucosamine-1-phosphoryl)-L-serine A protein modification that effectively converts an L-serine residue to O-(N-acetylglucosamine-1-phosphoryl)-L-serine. 0 DeltaMass 6438439 PubMed 6993483 PubMed 8631906 PubMed AA0296 RESID 428 UniMod (2S)-2-amino-3-[([(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy][hydroxy]phosphoryl)oxy]propanoic acid RESID-systematic N-acetylglucosamine-1-phosphoryl UniMod-description O-(N-acetylglucosamine-1-phosphoryl)-L-serine RESID-name O-beta(N-acetyl-glucosamine-alpha1-phosphate)serine RESID-alternate O-GlcNAc-1-phosphorylation (of Serine) DeltaMass-label O3-(N-acetylglucosamine-1-phosphoryl)-L-serine RESID-alternate O3-L-serine 2-(acetylamino)-2-deoxy-D-glucopyranose 1-phosphodiester RESID-alternate PhosphoHexNAc PSI-MS-label DiffAvg 283.17 DiffFormula C 8 H 14 N 1 O 8 P 1 DiffMono 283.045703 Formula C 11 H 19 N 2 O 10 P 1 MassAvg 370.25 MassMono 370.077731 Origin S Source natural TermSpec none MOD:00916 MOD:01804 PSI-MOD MOD:00302 O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine A protein modification that effectively converts an L-serine residue to O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. 10037765 PubMed 15649890 PubMed AA0297 RESID 429 UniMod O-(alpha-D-mannosyl-1-phosphoryl)-L-serine RESID-alternate O-(D-mannose-1-phosphoryl)-L-serine RESID-name O-[alpha-D-mannopyranosyloxy(hydroxy)phosphoryl]-L-serine RESID-systematic O3-(D-mannose-1-phosphoryl)-L-serine RESID-alternate O3-L-serine alpha-D-mannopyranose 1-phosphodiester RESID-alternate phosphoglycosyl-D-mannose-1-phosphoryl UniMod-description PhosphoHex PSI-MS-label DiffAvg 242.12 DiffFormula C 6 H 11 N 0 O 8 P 1 DiffMono 242.019154 Formula C 9 H 16 N 1 O 10 P 1 MassAvg 329.20 MassMono 329.051182 Origin S Source natural TermSpec none MOD:00916 MOD:01804 PSI-MOD MOD:00303 heptakis-L-histidino tetracopper mu4-sulfide hydroxide A protein modification that effectively converts seven L-histidinine residues and a four-copper one-sulfur one-hydroxide cluster to heptakis-L-histidino tetracopper mu4-sulfide hydroxide. 11024061 PubMed 11041839 PubMed AA0298 RESID Cross-link 7. heptakis-L-histidino tetracopper mu4-sulfide hydroxide RESID-name mu4-sulfido bis(bis-N1'-histidino copper)(N1'-histidino-N3'-histidino copper)(N3'-histidino hydroxide copper) RESID-systematic nitrous oxide reductase nosZ CuZ cluster RESID-alternate pentakis-L-N1'-histidino-bis-L-N3'-histidino tetracopper sulfide hydroxide RESID-alternate DiffAvg 296.19 DiffFormula C 0 Cu 4 H -6 N 0 O 1 S 1 DiffMono 293.638425 Formula C 42 Cu 4 H 43 N 21 O 8 S 1 MassAvg 1256.19 MassMono 1253.050808 Origin H, H, H, H, H, H, H Source natural TermSpec none MOD:00742 MOD:00860 MOD:00909 PSI-MOD MOD:00304 L-leucine methyl ester A protein modification that effectively converts an L-leucine residue to L-leucine methyl ester. 10191253 PubMed 11875433 PubMed 8206937 PubMed AA0299 RESID 34#C-term UniMod incidental to RESID:AA0039 PSI-MOD-slim 2-amino-4-methylpentanoic methyl ester RESID-alternate alpha-aminoisocaproic methyl ester RESID-alternate L-leucine methyl ester RESID-name Methyl PSI-MS-label methyl (2S)-2-amino-4-methylpentanoate RESID-systematic methyl esterified L-leucine PSI-MOD-alternate methyl L-leucinate RESID-alternate Methylation UniMod-description MOD_RES Leucine methyl ester UniProt-feature OMeLeu PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 14 N 1 O 2 MassAvg 144.19 MassMono 144.102454 Origin L Source natural TermSpec C-term MOD:00599 MOD:00662 MOD:01689 PSI-MOD MOD:00305 hexakis-L-cysteinyl L-serinyl octairon heptasulfide A protein modification that effectively converts six L-cysteine residues, an L-serine residue and a eight-iron seven-sulfur cluster to hexakis-L-cysteinyl L-serinyl octairon heptasulfide. 10525412 PubMed 12215645 PubMed 9063865 PubMed AA0300 RESID Cross-link 7; incidental to RESID:AA0141. Cys6Ser-[8Fe7S] PSI-MOD-label hexakis-L-cysteinyl L-serinyl octairon heptasulfide RESID-name METAL Iron-sulfur (8Fe-7S) UniProt-feature nitrogenase P-cluster RESID-alternate DiffAvg 663.12 DiffFormula C 0 Fe 8 H -8 N 0 O 0 S 7 DiffMono 663.223042 FormalCharge 3- Formula C 21 Fe 8 H 27 N 7 O 8 S 13 MassAvg 1369.03 MassMono 1368.310179 Origin C, C, C, C, C, C, S Source natural TermSpec none MOD:00739 MOD:00905 MOD:00916 PSI-MOD MOD:00306 residues isobaric at 113.084064 Da Natural or modified residues with a mass of 113.084064 Da. 10523135 PubMed AA0301 RESID PSI-MOD-slim L-isoleucine or L-leucine RESID-name Xle PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin X Source none TermSpec none MOD:00569 MOD:00624 PSI-MOD MOD:00307 L-aspartimide A protein modification that effectively cyclizes an L-asparagine residue to form a carboxyl-terminal L-aspartimide. 18 DeltaMass 12771378 PubMed 2378679 PubMed 7662664 PubMed 7988548 PubMed 9309583 PubMed AA0302 RESID 23#N UniMod From DeltaMass: Average Mass: -17 Average Mass Change:-17 References:Clarke, S., Lability of Aspargine and Aspartic Acid Residues in Protein and Peptides, in: Stability of Protein Pharmaceuticals : Chemical and Physical Paths of Protein Degradation, Part A (T.J. Ahern and M.C. Manning, eds.), 1992,Plenum Press, New York, pp.1-29Xie, M.; Vander Velde, D.; Morton, M.; Borchardt, R.T.; Schowen,R.L.: pH-Induced Change in the Rate-Determining Step for the Hydrolysis of the Asp/Asn-Derived Cyclic-Imide Intermediate in Protein Degradation. (1996) J. Am. Chem. Soc. 118: 8955-8956. (3S)-3-amino-2,5-pyrrolidinedione RESID-systematic 2-amino-butanimide RESID-alternate alpha-aminosuccinimide RESID-alternate ASI RESID-alternate Dehydrated UniMod-interim Dehydration UniMod-description L-2-aminosuccinimide RESID-alternate L-3-aminosuccinimide RESID-misnomer L-asparaginimide RESID-alternate L-aspartimide RESID-name Succinimide formation from asparagine DeltaMass-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 4 H 5 N 2 O 2 MassAvg 113.10 MassMono 113.035102 Origin N Source natural TermSpec C-term MOD:00601 MOD:00704 MOD:00903 PSI-MOD MOD:00308 L-glutamimide A protein modification that effectively cyclizes an L-glutamine residue to form a carboxyl-terminal L-glutamimide. 12771378 PubMed 14593103 PubMed AA0303 RESID 23#Q UniMod (3S)-3-aminopiperidine-2,6-dione RESID-systematic 2-aminopentanimide RESID-alternate 3-amino-2,6-piperidinedione RESID-alternate alpha-aminoglutarimide RESID-alternate Dehydrated UniMod-interim Dehydration UniMod-description L-glutamimide RESID-name DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 5 H 7 N 2 O 2 MassAvg 127.12 MassMono 127.050752 Origin Q Source hypothetical TermSpec C-term MOD:00601 MOD:00704 MOD:00907 PSI-MOD MOD:00309 L-beta-carboxyaspartic acid A protein modification that effectively converts an L-aspartic acid residue to L-beta-carboxyaspartic acid. 6390094 PubMed 7138832 PubMed 7457858 PubMed 8135347 PubMed AA0304 RESID 299#D UniMod References to this modification as a gamma-carboxylation are in error [JSG]. (2S)-2-aminoethane-1,1,2-tricarboxylic acid RESID-systematic 2-amino-3-carboxybutanedioic acid RESID-alternate 3-carboxy-L-aspartic acid RESID-name 3-carboxyaspartic acid RESID-alternate 3CbxAsp PSI-MOD-label beta-carboxyaspartic acid RESID-alternate Carboxy PSI-MS-label Carboxy UniMod-interim Carboxylation UniMod-description gammacarboxyld OMSSA-label DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 DiffMono 43.989829 Formula C 5 H 5 N 1 O 5 MassAvg 159.10 MassMono 159.016772 Origin D Source hypothetical TermSpec none MOD:00904 MOD:01152 PSI-MOD MOD:00310 N5-methyl-L-arginine A protein modification that effectively converts an L-arginine residue to N5-methyl-L-arginine. 11875433 PubMed 9792625 PubMed 9873020 PubMed AA0305 RESID (2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic acid RESID-systematic delta-N-methylarginine RESID-alternate Methyl PSI-MS-label Methylation UniMod-description MOD_RES N5-methylarginine UniProt-feature N5-carbamimidoyl-N5-methyl-L-ornithine RESID-alternate N5-methyl-L-arginine RESID-name N5-methylated L-arginine PSI-MOD-alternate N5Me1Arg PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 14 N 4 O 1 MassAvg 170.22 MassMono 170.116761 Origin R Source hypothetical TermSpec none MOD:00414 MOD:00602 PSI-MOD MOD:00311 L-cysteine coenzyme A disulfide A protein modification that effectively converts an L-cysteine residue to L-cysteine coenzyme A disulfide. 0 DeltaMass 1734967 PubMed AA0306 RESID 281#C UniMod DeltaMass gives no formula with mass as 454. (2R)-2-amino-3-(2-((3-(((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino)-1-oxopropyl)amino)ethyl)dithio-propanoic acid 4'-ester with adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) RESID-systematic coenzyme A L-cysteine mixed disulfide RESID-alternate CoenzymeA PSI-MS-label Cysteine modified Coenzyme A UniMod-description L-cysteine coenzyme A disulfide RESID-name SCoACys PSI-MOD-label DiffAvg 765.52 DiffFormula C 21 H 34 N 7 O 16 P 3 S 1 DiffMono 765.099559 Formula C 24 H 39 N 8 O 17 P 3 S 2 MassAvg 868.66 MassMono 868.108744 Origin C Source hypothetical TermSpec none MOD:00861 MOD:00905 MOD:01862 PSI-MOD MOD:00312 S-myristoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-myristoyl-L-cysteine. 10026218 PubMed 10080938 PubMed 8824274 PubMed AA0307 RESID 45#C UniMod (R)-2-amino-3-(tetradecanoylsulfanyl)propanoic acid RESID-systematic LIPID S-myristoyl cysteine UniProt-feature Myristoyl PSI-MS-label Myristoylation UniMod-description S-(C14:1 aliphatic acyl)cysteine PSI-MOD-alternate S-myristoyl-L-cysteine RESID-name S-myristoylated L-cysteine PSI-MOD-alternate SMyrCys PSI-MOD-label tetradecanoate cysteine thioester RESID-alternate DiffAvg 210.36 DiffFormula C 14 H 26 N 0 O 1 S 0 DiffMono 210.198365 Formula C 17 H 31 N 1 O 2 S 1 MassAvg 313.50 MassMono 313.207550 Origin C Source hypothetical TermSpec none MOD:00655 MOD:00905 PSI-MOD MOD:00313 S-palmitoleyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-palmitoleyl-L-cysteine. 8294460 PubMed AA0308 RESID 431#C UniMod (R)-2-amino-3-((Z)-9-hexadecenoylsulfanyl)propanoic acid RESID-systematic cis-9-hexadecenoate cysteine thioester RESID-alternate mod187 OMSSA-label Palmitoleyl PSI-MS-label palmitoleyl UniMod-description S-palmitoleyl-L-cysteine RESID-name S-palmitoleylated L-cysteine PSI-MOD-alternate SPamD1Cys PSI-MOD-label DiffAvg 236.40 DiffFormula C 16 H 28 N 0 O 1 S 0 DiffMono 236.214016 Formula C 19 H 33 N 1 O 2 S 1 MassAvg 339.54 MassMono 339.223200 Origin C Source hypothetical TermSpec none MOD:00672 MOD:00905 MOD:01423 PSI-MOD MOD:00314 glycine cholesterol ester A protein modification that effectively converts a glycine residue to glycine cholesterol ester. 11111088 PubMed 8824192 PubMed AA0309 RESID 432#C-term UniMod Incidental to RESID:AA0060. UniMod origin corrected [JSG]. PSI-MOD-slim C-cholesterol UniMod-interim cholesterol ester UniMod-description cholesteryl glycinate RESID-alternate glycine cholest-5-en-3beta-ol ester RESID-systematic glycine cholesterol ester RESID-name hedgehog lipophilic adduct RESID-alternate LIPID Cholesterol glycine ester UniProt-feature DiffAvg 368.65 DiffFormula C 27 H 44 N 0 O 0 DiffMono 368.344301 Formula C 29 H 48 N 1 O 2 MassAvg 442.71 MassMono 442.368505 Origin G Source natural TermSpec C-term MOD:00908 MOD:01155 PSI-MOD MOD:00315 pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide A protein modification that effectively converts five L-cysteine residues, an L-histidine residue and a one-nickel four-iron five-sulfur cluster to pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide. 11509720 PubMed 2550436 PubMed AA0310 RESID Cross-link 6. carbon monoxide dehydrogenase nickel-iron cofactor RESID-alternate METAL Nickel-iron-sulfur (Ni-4Fe-5S) UniProt-feature METAL Nickel-iron-sulfur (Ni-4Fe-5S); via tele nitrogen UniProt-feature mu-1:2kappaS-sulfido-mu3-1:3:5kappaS-sulfido-mu3-2:3:4kappaS-sulfido-mu3-2:4:5kappaS-sulfido-mu3-3:4:5kappaS-sulfido-N1'-histidino-S-cysteinyl-1-iron-S-cysteinyl-2-nickel-3,4,5-tris-(S-cysteinyl iron) RESID-systematic Ni-4Fe-5S cluster RESID-alternate pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide RESID-name DiffAvg 436.33 DiffFormula C 0 Fe 4 H -6 N 0 Ni 1 O 0 S 5 DiffMono 435.488498 Formula C 21 Fe 4 H 26 N 8 Ni 1 O 6 S 10 MassAvg 1089.16 MassMono 1087.593333 Origin C, C, C, C, C, H Source natural TermSpec none MOD:00739 MOD:00741 MOD:00905 MOD:00909 PSI-MOD MOD:00316 N4,N4-dimethyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4,N4-dimethyl-L-asparagine. 12964758 PubMed 14570711 PubMed 8783012 PubMed AA0311 RESID 36#N UniMod (2S)-2-amino-4-(dimethylamino)-4-oxobutanoic acid RESID-systematic 2-amino-N4,N4-dimethylbutanediamic acid RESID-alternate beta-dimethylasparagine RESID-misnomer di-Methylation UniMod-description Dimethyl PSI-MS-label MOD_RES N4,N4-dimethylasparagine UniProt-feature N(gamma),N(gamma)-dimethylasparagine RESID-alternate N4,N4-dimethyl-L-asparagine RESID-name N4,N4-dimethylated L-asparagine PSI-MOD-alternate N4Me2Asn PSI-MOD-label DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 6 H 10 N 2 O 2 MassAvg 142.16 MassMono 142.074228 Origin N Source hypothetical TermSpec none MOD:00429 MOD:00602 MOD:00673 PSI-MOD MOD:00317 N6-3,4-didehydroretinylidene-L-lysine A protein modification that effectively converts an L-lysine residue to N6-3,4-didehydroretinylidene-L-lysine. 10717661 PubMed 3257009 PubMed 4056688 PubMed AA0312 RESID 433#K UniMod (S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid RESID-systematic 3,4-didehydroretinylidene UniMod-description Didehydroretinylidene PSI-MS-label N6-(3,4-didehydroretinylidene)-L-lysine RESID-name N6-3-dehydroretinal-L-lysine RESID-alternate N6-3-dehydroretinyl-lysine RESID-alternate DiffAvg 264.41 DiffFormula C 20 H 24 N 0 O 0 DiffMono 264.187801 Formula C 26 H 36 N 2 O 1 MassAvg 392.59 MassMono 392.282764 Origin K Source natural TermSpec none MOD:00912 PSI-MOD MOD:00318 4'-(S-L-cysteinyl)-L-tryptophyl quinone A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone. 11555656 PubMed 11717396 PubMed AA0313 RESID Cross-link 2; secondary to RESID:AA0148. (2R)-2-amino-3-[(3-[(2S)-2-amino-2-carboxyethyl]-6,7-dioxo-6,7-dihydro-1H-indol-4-yl)sulfanyl]propanoic acid RESID-systematic 3-(2-amino-2-carboxyethyl)-4-[2-amino-2-carboxyethyl]sulfanyl-6,7-indolinedione RESID-alternate 4'-(L-cystein-S-yl)-L-tryptophyl quinone RESID-name 4-(S-cysteinyl)tryptophan-6,7-dione RESID-alternate CROSSLNK 4'-cysteinyl-tryptophylquinone (Cys-Trp) UniProt-feature CTQ RESID-alternate cysteine tryptophylquinone RESID-alternate DiffAvg 27.97 DiffFormula C 0 H -4 N 0 O 2 S 0 DiffMono 27.958529 Formula C 14 H 11 N 3 O 4 S 1 MassAvg 317.32 MassMono 317.047027 Origin C, W Source natural TermSpec none MOD:00687 MOD:00918 PSI-MOD MOD:00319 3-(S-L-cysteinyl)-L-aspartic acid A protein modification that effectively cross-links an L-cysteine residue and an L-aspartic acid residue by a thioether bond to form 2-(S-L-cysteinyl)-L-aspartic acid. 11555656 PubMed 11717396 PubMed AA0314 RESID Cross-link 2. (2R,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanedioic acid RESID-systematic (2R,3S,6R)-2,6-diamino-3-carboxy-4-thiaheptanedioic acid RESID-alternate 3-(L-cystein-S-yl)-L-aspartic acid RESID-name 3-carboxy-L-lanthionine RESID-alternate CROSSLNK 3-cysteinyl-aspartic acid (Cys-Asp) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 7 H 8 N 2 O 4 S 1 MassAvg 216.21 MassMono 216.020478 Origin C, D Source natural TermSpec none MOD:00904 MOD:01993 PSI-MOD MOD:00320 4-(S-L-cysteinyl)-L-glutamic acid A protein modification that effectively cross-links an L-cysteine residue and an L-glutamic acid residue by a thioether bond to form 4-(S-L-cysteinyl)-L-glutamic acid. 20293 ChEBI 11555656 PubMed 11717396 PubMed AA0315 RESID Cross-link 2. (2S,3S,7R)-2,7-diamino-4-carboxy-5-thiaoctanedioic acid RESID-alternate (2S,4S)-2-amino-4-[(R)-2-amino-2-carboxyethyl]sulfanylpentanedioic acid RESID-systematic 4-(L-cystein-S-yl)-L-glutamic acid RESID-name CROSSLNK 4-cysteinyl-glutamic acid (Cys-Glu) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 8 H 10 N 2 O 4 S 1 MassAvg 230.24 MassMono 230.036128 Origin C, E Source natural TermSpec none MOD:00687 MOD:00906 PSI-MOD MOD:00321 cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester A protein modification that effectively converts an L-aspartic acid residue to cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester. 11435437 PubMed 7949339 PubMed AA0316 RESID 434#D UniMod (7Z,14Xi)-14-[(S)-3-amino-3-carboxy-propanoyl]oxy-10,13-dioxo-7-heptadecenoic acid RESID-systematic barley lipid transfer protein modification RESID-alternate CHDH PSI-MS-label cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester RESID-name cis-14-hydroxy-10,13-dioxo-7-heptadecenoic ester UniMod-description LIPID Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester UniProt-feature DiffAvg 294.39 DiffFormula C 17 H 26 N 0 O 4 DiffMono 294.183109 Formula C 21 H 31 N 1 O 7 MassAvg 409.48 MassMono 409.210052 Origin D Source natural TermSpec none MOD:00904 MOD:01155 PSI-MOD MOD:00322 1'-methyl-L-histidine A protein modification that effectively converts an L-histidine residue to tele-methyl-L-histidine. 10601317 PubMed 11474090 PubMed 11875433 PubMed 6692818 PubMed 8076 PubMed 8645219 PubMed AA0317 RESID PSI-MOD-slim (S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid RESID-systematic 1'-methyl-L-histidine RESID-name 3-methylhistidine RESID-misnomer 4-methyl-histidine RESID-misnomer Methyl PSI-MS-label Methylation UniMod-description MOD_RES Tele-methylhistidine UniProt-feature N(epsilon)-methylhistidine RESID-alternate N(tau)-methylhistidine RESID-alternate NteleMeHis PSI-MOD-label tele-methylated L-histidine PSI-MOD-alternate tele-methylhistidine RESID-alternate DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 9 N 3 O 1 MassAvg 151.17 MassMono 151.074562 Origin H Source natural TermSpec none MOD:00724 PSI-MOD MOD:00323 L-lysine methyl ester A protein modification that effectively converts an L-lysine residue to L-lysine methyl ester. 10973948 PubMed 11875433 PubMed AA0318 RESID 34#C-term UniMod PSI-MOD-slim 2,6-diaminohexanoic methyl ester RESID-alternate alpha,epsilon-diaminocaproic methyl ester RESID-alternate L-lysine methyl ester RESID-name Methyl PSI-MS-label methyl (S)-2,6-diaminohexanoate RESID-systematic methyl esterified L-lysine PSI-MOD-alternate methyl L-lysinate RESID-alternate Methylation UniMod-description MOD_RES Lysine methyl ester UniProt-feature OMeLys PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 15 N 2 O 2 MassAvg 159.21 MassMono 159.113353 Origin K Source natural TermSpec C-term MOD:01683 MOD:01689 PSI-MOD MOD:00324 L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) A protein modification that effectively converts an L-serine residue to L-serinyl molybdenum bis(molybdopterin guanine dinucleotide). 8658132 PubMed 8658134 PubMed AA0319 RESID 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide RESID-alternate bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-O3-serinyl-molybdenum oxide RESID-systematic L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) RESID-name DiffAvg 1588.01 DiffFormula C 40 H 47 Mo 1 N 20 O 27 P 4 S 4 DiffMono 1588.980690 Formula C 43 H 52 Mo 1 N 21 O 29 P 4 S 4 MassAvg 1675.09 MassMono 1676.012718 Origin S Source natural TermSpec none MOD:00744 MOD:00916 PSI-MOD MOD:00325 L-beta-methylthioasparagine A protein modification that effectively converts an L-asparagine residue to L-beta-methylthioasparagine. AA0320 RESID 39#N UniMod This modification was predicted for ribosomal protein S12 in Bacillus subtilis when the sequence in the original version of the genome was reported to have asparagine rather than aspartic acid at the position of the methylthioaspartic acid modification (see MOD:00237). Two groups independently confirmed that the genome sequence was incorrect. The sequence in the revised genome has aspartic acid at that position. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. (2R,3Xi)-2-amino-3-(methylsulfanyl)-4-butanediamic acid RESID-systematic 2,4-diamino-3-(methylsulfanyl)-4-oxobutanoic acid RESID-alternate 3-(methylthio)-L-asparagine RESID-name 3-carboxamido-S-methyl-cysteine RESID-alternate beta-(methylthio)asparagine RESID-alternate Beta-methylthiolation UniMod-description Methylthio UniMod-interim DiffAvg 46.09 DiffFormula C 1 H 2 N 0 O 0 S 1 DiffMono 45.987721 Formula C 5 H 8 N 2 O 2 S 1 MassAvg 160.19 MassMono 160.030649 Origin N Source hypothetical TermSpec none MOD:00903 MOD:01153 PSI-MOD MOD:00326 L-pyrrolysine (Lys) A protein modification that effectively converts an L-lysine residue to L-pyrrolysine (not known as a natural, post-translational modification process). 11435424 PubMed 12029131 PubMed 12029132 PubMed 15314242 PubMed 16096277 PubMed AA0321#LYS RESID 435#K UniMod This entry is for the artifactual formation of L-pyrrolysine from lysine. For encoded L-pyrrolysine, use MOD:01187 [JSG]. (2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid RESID-systematic 2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid RESID-alternate L-pyrrolysine RESID-name monomethylamine methyltransferase cofactor lysine adduct RESID-alternate N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine RESID-alternate N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine RESID-alternate N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine RESID-alternate NON_STD Pyrrolysine UniProt-feature Pyl(Lys) PSI-MOD-label DiffAvg 109.13 DiffFormula C 6 H 7 N 1 O 1 DiffMono 109.052764 Formula C 12 H 19 N 3 O 2 MassAvg 237.30 MassMono 237.147727 Origin K Source artifact TermSpec none MOD:00912 MOD:01187 PSI-MOD MOD:00327 3-hydroxy-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to a 3-hydroxy-L-tryptophan. 10024453 PubMed 11457355 PubMed AA0322 RESID (2S,3S)-2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid RESID-systematic 3-hydroxy-L-tryptophan RESID-name 3-hydroxylated L-tryptophan PSI-MOD-alternate 3-hydroxytryptophan RESID-alternate 3HyTrp PSI-MOD-label beta-hydroxytryptophan RESID-alternate MOD_RES 3-hydroxytryptophan UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 11 H 10 N 2 O 2 MassAvg 202.21 MassMono 202.074228 Origin W Source hypothetical TermSpec none MOD:01622 PSI-MOD MOD:00328 O4'-(phospho-3'-DNA)-L-tyrosine A protein modification that effectively crosslinks an L-tyrosine residue and the 3'-end of DNA through a phosphodiester bond to form O4'-(phospho-3'-DNA)-L-tyrosine. 2211714 PubMed AA0323 RESID (S)-2-amino-3-[4-(3'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid RESID-systematic ACT_SITE O-(3'-phospho-DNA)-tyrosine intermediate UniProt-feature O4'-(phospho-3'-DNA)-L-tyrosine RESID-name O4'-L-tyrosine 3'-DNA phosphodiester RESID-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 9 H 10 N 1 O 5 P 1 MassAvg 243.15 MassMono 243.029659 Origin Y Source natural TermSpec none MOD:00750 MOD:00919 PSI-MOD MOD:00329 hydroxyheme-L-glutamate ester A protein modification that effectively results from forming an adduct between a glutamic acid residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 11139583 PubMed 11821421 PubMed 11980497 PubMed AA0324 RESID 436#E UniMod 5-hydroxymethyl protoporphyrin IX 5-glutamate ester RESID-alternate [3-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-7,12-diethenyl-8,13,17-trimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate RESID-systematic BINDING Heme (covalent; via 1 link) UniProt-feature cytochrome P450 CYP4A family heme cofactor RESID-alternate Hydroxyheme PSI-MS-label hydroxyheme UniMod-description hydroxyheme-L-glutamate ester RESID-name DiffAvg 614.48 DiffFormula C 34 Fe 1 H 30 N 4 O 4 DiffMono 614.161643 Formula C 39 Fe 1 H 37 N 5 O 7 MassAvg 743.60 MassMono 743.204236 Origin E Source natural TermSpec none MOD:00699 MOD:00906 PSI-MOD MOD:00330 (phospho-5'-guanosine)-L-histidine A protein modification that effectively converts an L-histidine residue to a (phospho-5'-guanosine)-L-histidine. 10529169 PubMed 10869342 PubMed 7559521 PubMed AA0325 RESID 413#H UniMod (2S)-2-amino-3-(1-(5'-adenosine phosphono)imidazol-4-yl)propanoic acid RESID-systematic 1'-(phospho-5'-guanosine)-L-histidine RESID-name ACT_SITE GMP-histidine intermediate UniProt-feature L-histidine 5'-guanosine phosphoramidester RESID-alternate L-histidine monoanhydride with 5'-guanylic acid RESID-alternate N(tau)-5'-guanylic-L-histidine RESID-alternate N1'-guanylylated histidine RESID-alternate phospho-guanosine UniMod-description Phosphoguanosine PSI-MS-label tele-5'-guanylic-L-histidine RESID-alternate DiffAvg 345.21 DiffFormula C 10 H 12 N 5 O 7 P 1 DiffMono 345.047434 Formula C 16 H 19 N 8 O 8 P 1 MassAvg 482.35 MassMono 482.106346 Origin H Source natural TermSpec none MOD:00909 MOD:01163 PSI-MOD MOD:00331 tetrakis-L-cysteinyl triiron tetrasulfide A protein modification that effectively converts four L-cysteine residues and a three-iron four-sulfur cluster to tetrakis-L-cysteinyl triiron tetrasulfide. 11592901 PubMed 11941493 PubMed 2511202 PubMed 6094558 PubMed AA0326 RESID Cross-link 4. bis[bis-L-cysteinyl iron disulfido]iron RESID-alternate di-mu-1:2kappaS-sulfido di-mu-2:3kappaS-sulfido iron bis(bis-S-cysteinyliron) RESID-systematic tetra-mu-sulfido tetrakis-S-L-cysteinyl triiron RESID-alternate tetrakis-L-cysteinyl linear [3Fe-4S] cluster RESID-alternate tetrakis-L-cysteinyl triiron tetrasulfide RESID-name tetrakis-L-cysteinyl triiron tetrasulfide D2 cluster RESID-alternate DiffAvg 291.74 DiffFormula C 0 Fe 3 H -4 N 0 O 0 S 4 DiffMono 291.663442 FormalCharge 3- Formula C 12 Fe 3 H 16 N 4 O 4 S 8 MassAvg 704.30 MassMono 703.700181 Origin C, C, C, C Source hypothetical TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00332 omega-N-glucosyl-L-arginine A protein modification that effectively converts an L-arginine residue to N4-glucosyl-arginine. 15279557 PubMed 8521968 PubMed 9536051 PubMed AA0327 RESID 41#R UniMod (2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid RESID-systematic Hex PSI-MS-label Hexose UniMod-description NG-beta-D-glucosylarginine RESID-alternate omega-N-(beta-D-glucosyl)-L-arginine RESID-alternate omega-N-glucosyl-L-arginine RESID-name omega-N-glycosyl-L-arginine RESID-alternate DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 12 H 22 N 4 O 6 MassAvg 318.33 MassMono 318.153934 Origin R Source natural TermSpec none MOD:00433 MOD:00761 MOD:01980 PSI-MOD MOD:00333 (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine A protein modification that effectively converts an L-asparagine residue to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine. 7559516 PubMed 7835418 PubMed 8183363 PubMed AA0328 RESID 437#C-term UniMod UniMod origin shown as C-term [JSG]. (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine RESID-name (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5-adenosine UniMod-description 5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]adenosine RESID-systematic 9-(5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]-beta-D-ribofuranosyl)adenine RESID-alternate C-Asn-deriv UniMod-interim microcin C7 asparagine modification RESID-alternate MOD_RES Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide UniProt-feature N-(aspart-1-yl)-O-(3-aminopropyl)-O-(5'-adenosyl)phosphoramide RESID-alternate DiffAvg 386.30 DiffFormula C 13 H 19 N 6 O 6 P 1 DiffMono 386.110369 Formula C 17 H 26 N 8 O 9 P 1 MassAvg 517.42 MassMono 517.156036 Origin N Source natural TermSpec C-term MOD:00701 MOD:00903 PSI-MOD MOD:00334 1'-heme-L-histidine A protein modification that effectively results from forming an adduct between the tele nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. 12033922 PubMed 12121092 PubMed AA0329 RESID 390#H UniMod (S)-[7-ethenyl-12-[1-((2-amino-2-carboxyethyl)-1H-imidazol-1-yl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate RESID-systematic 1'-heme-L-histidine RESID-name 2-[1-(N1'-histidyl)ethyl]protoporphyrin IX RESID-alternate BINDING Heme (covalent; via tele nitrogen) UniProt-feature Heme PSI-MS-label heme UniMod-description N(epsilon)-histidyl heme RESID-alternate N(tau)-histidyl heme RESID-alternate N1'-histidyl heme RESID-alternate tele-histidyl heme RESID-alternate DiffAvg 616.50 DiffFormula C 34 Fe 1 H 32 N 4 O 4 DiffMono 616.177293 Formula C 40 Fe 1 H 39 N 7 O 5 MassAvg 753.64 MassMono 753.236205 Origin H Source hypothetical TermSpec none MOD:00699 MOD:00909 PSI-MOD MOD:00335 (2S,3S,2'R)-3-methyllanthionine sulfoxide A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine sulfoxide. 7737178 PubMed 9219543 PubMed AA0330 RESID Cross-link 2. (2S,3S,4Xi,6R)-2,6-diamino-3-methyl-4-oxo-4-thiaheptanedioic acid RESID-alternate (2S,3S,SXi)-2-amino-3-([(R)-2-amino-2-carboxyethyl]sulfinyl)butanoic acid RESID-systematic 3-methyl-L-lanthionine S-oxide RESID-alternate 3-methyl-L-lanthionine sulfoxide RESID-name CROSSLNK Beta-methyllanthionine sulfoxide (Thr-Cys) UniProt-feature S-oxy-3-methyllanthionine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 7 H 10 N 2 O 3 S 1 MassAvg 202.23 MassMono 202.041213 Origin C, T Source natural TermSpec none MOD:00917 MOD:01993 has_functional_parent MOD:019810 PSI-MOD MOD:00336 tris-L-cysteinyl L-aspartato diiron disulfide A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-aspartato diiron disulfide. 10968624 PubMed 1312028 PubMed 7947772 PubMed AA0331 RESID Cross-link 4. di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-O4-aspartatoiron) RESID-systematic METAL Iron-sulfur (2Fe-2S) UniProt-feature tris-L-cysteinyl L-aspartato diiron disulfide RESID-name DiffAvg 171.78 DiffFormula C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono 171.783814 FormalCharge 2- Formula C 13 Fe 2 H 16 N 4 O 6 S 5 MassAvg 596.28 MassMono 595.838311 Origin C, C, C, D Source hypothetical TermSpec none MOD:00739 MOD:00904 MOD:00905 PSI-MOD MOD:00337 S-carbamoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-carbamoyl-L-cysteine. 12586941 PubMed 240389 PubMed AA0332 RESID 5#C UniMod (R)-2-amino-3-(carbamoylsulfanyl)propanoic acid RESID-systematic 2-amino-3-(aminocarbonyl)sulfanylpropanoic acid RESID-alternate 2-amino-3-(aminocarbonyl)thiopropanoic acid RESID-alternate alpha-amino-beta-carbamylthiopropionic acid RESID-alternate beta-carbamylthioalanine RESID-alternate MOD_RES S-carbamoylcysteine UniProt-feature S-(aminocarbonyl)cysteine RESID-alternate S-carbamoyl-L-cysteine RESID-name S-carbamoylcysteine RESID-alternate S-carbamylcysteine RESID-alternate S-cysteinyl carbamate ester RESID-alternate SCbmCys PSI-MOD-label DiffAvg 43.02 DiffFormula C 1 H 1 N 1 O 1 S 0 DiffMono 43.005814 Formula C 4 H 6 N 2 O 2 S 1 MassAvg 146.16 MassMono 146.014998 Origin C Source natural TermSpec none MOD:00398 MOD:00905 PSI-MOD MOD:00338 S-cyano-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-cyano-L-cysteine. 12586941 PubMed 4808702 PubMed AA0333 RESID 438#C UniMod (2R)-2-amino-3-thiocyanatopropanoic acid RESID-systematic alpha-amino-beta-thiocyanatopropionic acid RESID-alternate beta-thiocyanatoalanine RESID-alternate Cyano PSI-MS-label cyano UniMod-description MOD_RES S-cyanocysteine UniProt-feature S-cyano-L-cysteine RESID-name S-cyanocysteine RESID-alternate serine thiocyanic acid ester RESID-alternate DiffAvg 25.01 DiffFormula C 1 H -1 N 1 O 0 S 0 DiffMono 24.995249 Formula C 4 H 4 N 2 O 1 S 1 MassAvg 128.15 MassMono 128.004434 Origin C Source natural TermSpec none MOD:00893 MOD:00905 PSI-MOD MOD:00339 L-cysteinyl hydrogenase diiron subcluster A protein modification that effectively converts an L-cysteine residue to L-cysteinyl hydrogenase diiron subcluster. 10694885 PubMed 9836629 PubMed AA0334 RESID 439#C UniMod incidental to RESID:AA0140. 1,7-biscarbonyl-1-(cystein-S-yl)-8-oxo-4-aza-2lambda(3),6 lambda(3)-dithia-1,7-diferratricyclo[4.2.0.0(2,7)]octane-1,7-dicarbonitrile RESID-alternate Diironsubcluster PSI-MS-label hydrogenase diiron subcluster UniMod-description L-cysteinyl hydrogenase diiron subcluster RESID-name METAL Diiron subcluster UniProt-feature mu-carbonyl-dicarbonyl-1kappaC,2kappaC-dicyanido-1kappaC,2kappaC-cysteinato-1kS-1,2-azadimethanthiol-1kS,2kS'-diiron RESID-systematic DiffAvg 342.87 DiffFormula C 5 Fe 2 H -1 N 2 O 5 S 2 DiffMono 342.786913 Formula C 8 Fe 2 H 4 N 3 O 6 S 3 MassAvg 446.01 MassMono 445.796098 Origin C Source natural TermSpec none MOD:00738 MOD:00905 PSI-MOD MOD:00340 S-amidino-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-amidino-L-cysteine. 9148748 PubMed AA0335 RESID 440#C UniMod (2R)-2-amino-3-(carbamimidoylsulfanyl)propanoic acid RESID-systematic 2-amino-3-amidinosulfanylpropanoic acid RESID-alternate 2-amino-3-amidinothiopropanoic acid RESID-alternate ACT_SITE Amidino-cysteine intermediate UniProt-feature alpha-amino-beta-amidinothiopropionic acid RESID-alternate Amidino PSI-MS-label amidino UniMod-description beta-(S-isothiourea)alanine RESID-alternate beta-amidinothioalanine RESID-alternate S-amidino-L-cysteine RESID-name S-amidinocysteine RESID-alternate DiffAvg 42.04 DiffFormula C 1 H 2 N 2 O 0 S 0 DiffMono 42.021798 Formula C 4 H 7 N 3 O 1 S 1 MassAvg 145.18 MassMono 145.030983 Origin C Source natural TermSpec none MOD:00905 PSI-MOD MOD:00341 N-methyl-L-isoleucine A protein modification that effectively converts an L-isoleucine residue to N-methyl-L-isoleucine. 11875433 PubMed AA0336 RESID Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. (2S,3S)-2-methylamino-3-methylpentanoic acid RESID-systematic Methyl PSI-MS-label Methylation UniMod-description MOD_RES N-methylisoleucine UniProt-feature N-methyl-L-isoleucine RESID-name N-methylated L-isoleucine PSI-MOD-alternate N-methylisoleucine RESID-alternate NMe1Ile PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 13 N 1 O 1 MassAvg 127.19 MassMono 127.099714 Origin I Source hypothetical TermSpec none MOD:00715 MOD:01680 PSI-MOD MOD:00342 N-methyl-L-leucine A protein modification that effectively converts an L-leucine residue to N-methyl-L-leucine. 11875433 PubMed AA0337 RESID Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. (S)-2-methylamino-4-methylpentanoic acid RESID-systematic 2-(methylamino)-4-methyl-valeric acid RESID-alternate Methyl PSI-MS-label Methylation UniMod-description MOD_RES N-methylleucine UniProt-feature N-methyl-L-leucine RESID-name N-methylated L-leucine PSI-MOD-alternate N-methylleucine RESID-alternate NMe1Leu PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 13 N 1 O 1 MassAvg 127.19 MassMono 127.099714 Origin L Source hypothetical TermSpec none MOD:01680 MOD:01808 PSI-MOD MOD:00343 N-methyl-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to N-methyl-L-tyrosine. 0 DeltaMass AA0338 RESID Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. (2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid RESID-systematic Methyl PSI-MS-label MOD_RES N-methyltyrosine UniProt-feature N-methyl Tyrosinyl DeltaMass-label N-methyl-L-tyrosine RESID-name N-methylated L-tyrosine PSI-MOD-alternate N-methyltyrosine RESID-alternate NMe1Tyr PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 10 H 11 N 1 O 2 MassAvg 177.20 MassMono 177.078979 Origin Y Source hypothetical TermSpec none MOD:00718 MOD:01680 PSI-MOD MOD:00344 N-palmitoylglycine A protein modification that effectively converts a glycine residue to N-palmitoylglycine. 12574119 PubMed AA0339 RESID incidental to RESID:AA0060 PSI-MOD-slim (hexadecanamido)acetic acid RESID-alternate (hexadecanoylamino)acetic acid RESID-alternate (hexadecanoylamino)ethanoic acid RESID-systematic LIPID N-palmitoyl glycine UniProt-feature N-(1-oxohexadecyl)glycine RESID-alternate N-palmitoyl-glycine RESID-name N-palmitoylated glycine PSI-MOD-alternate NPamGly PSI-MOD-label DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 S 0 DiffMono 238.229666 Formula C 18 H 34 N 1 O 2 MassAvg 296.47 MassMono 296.258954 Origin G Source natural TermSpec N-term MOD:00908 MOD:01685 PSI-MOD MOD:00345 2-(S-L-cysteinyl)-L-phenylalanine A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-phenylalanine. 12696888 PubMed 3936839 PubMed AA0340 RESID Cross-link 2. (2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid RESID-systematic (2R,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid RESID-alternate 2-(L-cystein-S-yl)-L-phenylalanine RESID-name alpha-(L-cystein-S-yl)-L-phenylalanine RESID-alternate CROSSLNK 2-cysteinyl-L-phenylalanine (Cys-Phe) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 12 H 12 N 2 O 2 S 1 MassAvg 248.30 MassMono 248.061949 Origin C, F Source natural TermSpec none MOD:00914 MOD:01992 PSI-MOD MOD:00346 2-(S-L-cysteinyl)-D-phenylalanine A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-phenylalanine. 12696888 PubMed 3936839 PubMed AA0341 RESID Cross-link 2. (2S)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid RESID-systematic (2S,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid RESID-alternate 2-(L-cystein-S-yl)-D-phenylalanine RESID-name alpha-(L-cystein-S-yl)-D-phenylalanine RESID-alternate CROSSLNK 2-cysteinyl-D-phenylalanine (Cys-Phe) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 12 H 12 N 2 O 2 S 1 MassAvg 248.30 MassMono 248.061949 Origin C, F Source natural TermSpec none MOD:00664 MOD:00914 MOD:01992 PSI-MOD MOD:00347 2-(S-L-cysteinyl)-D-allo-threonine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-allo-threonine. 12696888 PubMed 3936839 PubMed AA0342 RESID Cross-link 2. (2R,5S,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid RESID-alternate (2S,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid RESID-systematic 2-(L-cystein-S-yl)-D-allo-threonine RESID-name alpha-(L-cystein-S-yl)-D-allo-threonine RESID-alternate CROSSLNK 2-cysteinyl-D-allo-threonine (Cys-Thr) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 7 H 10 N 2 O 3 S 1 MassAvg 202.23 MassMono 202.041213 Origin C, T Source natural TermSpec none MOD:00664 MOD:00917 MOD:01992 PSI-MOD MOD:00348 N-carbamoyl-L-alanine A protein modification that effectively converts an L-alanine residue to N-carbamoyl-L-alanine. 12203680 PubMed AA0343 RESID (S)-2-(carbamoylamino)propanoic acid RESID-systematic 2-ureidopropanoic acid RESID-alternate MOD_RES N-carbamoylalanine UniProt-feature N-carbamoyl-L-alanine RESID-name N-carbamylalanine RESID-alternate N2CbmAla PSI-MOD-label DiffAvg 43.02 DiffFormula C 1 H 1 N 1 O 1 DiffMono 43.005814 Formula C 4 H 7 N 2 O 2 MassAvg 115.11 MassMono 115.050752 Origin A Source natural TermSpec N-term MOD:00901 MOD:01679 PSI-MOD MOD:00349 4-amino-3-isothiazolidinone-L-serine A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form 4-amino-3-isothiazolidinone-L-serine. 12802338 PubMed 12802339 PubMed AA0344 RESID Cross-link 2. (2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-hydroxypropanoic acid RESID-systematic 2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-hydroxy-propanoic acid RESID-alternate 4-amino-3-isothiazolidinone-L-serine RESID-alternate CROSSLNK N,N-(cysteine-1,S-diyl)serine (Cys-Ser) UniProt-feature N,N-(L-cysteine-1,S-diyl)-L-serine RESID-name serine-cysteine sulfenyl amide cross-link RESID-alternate serine-cysteine sulphenyl amide cross-link RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 3 S 1 MassAvg 188.20 MassMono 188.025563 Origin C, S Source natural TermSpec none MOD:00905 MOD:00916 MOD:01861 PSI-MOD MOD:00350 L-threonyl-pentaglycyl-murein peptidoglycan A protein modification that effectively attaches an L-threonine residue to murein peptidoglycan by a pentaglycine linker peptide. 10754567 PubMed 1638631 PubMed AA0345 RESID (2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(threonyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine RESID-alternate L-threonyl-pentaglycyl-murein peptidoglycan RESID-name MOD_RES Pentaglycyl murein peptidoglycan amidated threonine UniProt-feature DiffAvg 268.25 DiffFormula C 10 H 14 N 5 O 4 DiffMono 268.104579 Formula C 14 H 22 N 6 O 7 MassAvg 386.37 MassMono 386.154997 Origin T Source natural TermSpec C-term MOD:00917 MOD:01159 PSI-MOD MOD:00351 N-glycyl-1-(phosphatidyl)ethanolamine A protein modification that effectively converts a glycine residue to N-glycyl-1-(phosphatidyl)ethanolamine. 11100732 PubMed AA0346 RESID (R)-1-hexadecanoyloxy-2-((Z)-9-octadecenoyloxy)-3-[2-(aminoacetylamino)ethyloxyphospho]propane RESID-systematic LIPID Phosphatidylethanolamine amidated glycine UniProt-feature N-glycyl-1-(phosphatidyl)ethanolamine RESID-name N-glycyl-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine RESID-alternate DiffAvg 699.99 DiffFormula C 39 H 74 N 1 O 7 P 1 DiffMono 699.520290 Formula C 41 H 78 N 2 O 9 P 1 MassAvg 774.05 MassMono 773.544494 Origin G Source natural TermSpec C-term MOD:00908 MOD:01155 PSI-MOD MOD:00352 L-glutamyl 5-omega-hydroxyceramide ester A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-omega-hydroxyceramide ester. 10411887 PubMed 9651377 PubMed AA0347 RESID (S)-2-amino-5-[30-((2S,3R,4E)-1,3-dihydroxyicos-4-en-2-ylamino)-30-oxotriacontan-1-yloxy]-5-oxopentanoic acid RESID-systematic 2-[30-(isoglutamyloxy)triacontanoyl]icosasphingosine RESID-alternate L-glutamyl 5-omega-hydroxyceramide ester RESID-name LIPID Omega-hydroxyceramide glutamate ester UniProt-feature DiffAvg 761.31 DiffFormula C 50 H 96 N 0 O 4 DiffMono 760.730862 Formula C 55 H 104 N 2 O 6 MassAvg 889.44 MassMono 888.789439 Origin Q Source natural TermSpec none MOD:00907 MOD:01155 PSI-MOD MOD:00353 S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium A protein modification that effectively cross-links an L-tryptophan residue with an L-tyrosine residue by a carbon-carbon bond, and cross-links the L-tyrosine residue to an L-methionine residue by a thioether bond to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium. 12172540 PubMed 16285713 PubMed AA0348 RESID Cross-link 3. 5'-(6'-tryptophyl)-tyrosin-3'-yl-methionin-S-ium RESID-alternate S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium RESID-name DiffAvg -3.02 DiffFormula C 0 H -3 N 0 O 0 S 0 DiffMono -3.024024 FormalCharge 1+ Formula C 25 H 25 N 4 O 4 S 1 MassAvg 477.56 MassMono 477.159103 Origin M, W, Y Source natural TermSpec none MOD:00692 MOD:00913 MOD:00918 MOD:00919 PSI-MOD MOD:00354 O-(riboflavin phosphoryl)-L-threonine A protein modification that effectively converts an L-threonine residue to O-(riboflavin phosphoryl)-L-threonine. 10587447 PubMed 11163785 PubMed 11248234 PubMed AA0349 RESID 442#T UniMod PSI-MOD-slim (2S,3R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)butanoic acid RESID-systematic FMN PSI-MS-label MOD_RES FMN phosphoryl threonine UniProt-feature O-(riboflavin phosphoryl)-L-threonine RESID-name O3-(riboflavin phosphoryl) UniMod-description O3-threonyl flavin mononucleotide RESID-alternate O3-threonyl FMN RESID-alternate OFMNThr PSI-MOD-label DiffAvg 438.33 DiffFormula C 17 H 19 N 4 O 8 P 1 DiffMono 438.094050 Formula C 21 H 26 N 5 O 10 P 1 MassAvg 539.44 MassMono 539.141729 Origin T Source hypothetical TermSpec none MOD:00917 MOD:01164 PSI-MOD MOD:00355 O-(riboflavin phosphoryl)-L-serine A protein modification that effectively converts an L-serine residue to O-(riboflavin phosphoryl)-L-serine. AA0350 RESID 442#S UniMod PSI-MOD-slim (R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)propanoic acid RESID-systematic FMN PSI-MS-label MOD_RES FMN phosphoryl serine UniProt-feature O-(riboflavin phosphoryl)-L-serine RESID-name O3-(riboflavin phosphoryl) UniMod-description O3-seryl flavin mononucleotide RESID-alternate O3-seryl FMN RESID-alternate OFMNSer PSI-MOD-label DiffAvg 438.33 DiffFormula C 17 H 19 N 4 O 8 P 1 DiffMono 438.094050 Formula C 20 H 24 N 5 O 10 P 1 MassAvg 525.41 MassMono 525.126079 Origin S Source hypothetical TermSpec none MOD:00916 MOD:01164 PSI-MOD MOD:00356 S-(4a-FMN)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(4a-FMN)-L-cysteine. 12668455 PubMed 12846567 PubMed 7692961 PubMed AA0351 RESID 443#C UniMod PSI-MOD-slim (R)-2-amino-3-(4a-riboflavin 5'-dihydrogen phosphate)sulfanylpropanoic acid RESID-systematic 4a-(S-cysteinyl)flavin mononucleotide RESID-alternate 4a-(S-cysteinyl)FMN RESID-alternate FMNC PSI-MS-label MOD_RES S-4a-FMN cysteine UniProt-feature S-(4a-FMN) UniMod-description S-(4a-FMN)-L-cysteine RESID-name S4aFMNCys PSI-MOD-label DiffAvg 456.35 DiffFormula C 17 H 21 N 4 O 9 P 1 S 0 DiffMono 456.104615 Formula C 20 H 26 N 5 O 10 P 1 S 1 MassAvg 559.49 MassMono 559.113800 Origin C Source natural TermSpec none MOD:00896 MOD:00905 PSI-MOD MOD:00357 1'-(8alpha-FMN)-L-histidine A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FMN)-L-histidine. 11902668 PubMed 8611516 PubMed AA0352 RESID 409#H UniMod PSI-MOD-slim (S)-2-amino-3-(1-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid RESID-systematic 1'-(8alpha-FMN)-L-histidine RESID-name 8alpha-(N(epsilon)-histidyl)FMN RESID-alternate 8alpha-(N1'-histidyl)FMN RESID-alternate flavin mononucleotide UniMod-description FMNH PSI-MS-label MOD_RES Tele-8alpha-FMN histidine UniProt-feature N(tau)-(8alpha-FMN)-histidine RESID-alternate Ntele8aFMNHis PSI-MOD-label tele-(8alpha-FMN)-histidine RESID-alternate DiffAvg 454.33 DiffFormula C 17 H 19 N 4 O 9 P 1 DiffMono 454.088965 Formula C 23 H 26 N 7 O 10 P 1 MassAvg 591.47 MassMono 591.147877 Origin H Source natural TermSpec none MOD:00896 MOD:00909 PSI-MOD MOD:00358 3'-(8alpha-FMN)-L-histidine A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FMN)-L-histidine. 12417325 PubMed AA0353 RESID 409#H UniMod In a later publication, PubMed:19438211, the authors changed the enzyme activity, the connection from a histidine nitrogen to a cysteine sulfur, and the identity of the flavin from FMN to FAD. They now believe the modification is S-(8alpha-FAD)-L-cysteine, see MOD:00152. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. PSI-MOD-slim (S)-2-amino-3-(3-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid RESID-systematic 3'-(8alpha-FMN)-L-histidine RESID-name 8alpha-(N(delta)-histidyl)FMN RESID-alternate 8alpha-(N3'-histidyl)FMN RESID-alternate flavin mononucleotide UniMod-description FMNH PSI-MS-label N(pi)-(8alpha-FMN)-histidine RESID-alternate Npros8aFMNHis PSI-MOD-label pros-(8alpha-FMN)-histidine RESID-alternate DiffAvg 454.33 DiffFormula C 17 H 19 N 4 O 9 P 1 DiffMono 454.088965 Formula C 23 H 26 N 7 O 10 P 1 MassAvg 591.47 MassMono 591.147877 Origin H Source hypothetical TermSpec none MOD:00896 MOD:00909 PSI-MOD MOD:00359 N2-acetyl-L-arginine A protein modification that effectively converts an L-arginine residue to N2-acetyl-L-arginine. 12883043 PubMed 1894641 PubMed AA0354 RESID (S)-2-acetamido-5-carbamimidamidopentanoic acid RESID-systematic 2-acetamido-5-guanidinopentanoic acid RESID-alternate 2-acetylamino-5-guanidinopentanoic acid RESID-alternate AcArg PSI-MOD-label acetylarginine RESID-alternate alpha-acetylamino-delta-guanidinovaleric acid RESID-alternate MOD_RES N2-acetylarginine UniProt-feature N(alpha)-acetylarginine RESID-alternate N2-acetyl-L-arginine RESID-name N2-acetylated L-arginine PSI-MOD-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 15 N 4 O 2 MassAvg 199.23 MassMono 199.119501 Origin R Source natural TermSpec N-term MOD:00902 MOD:01458 PSI-MOD MOD:00360 L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide A protein modification that effectively converts an L-cysteine residue to L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide. 12475995 PubMed AA0355 RESID 444#C UniMod [8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with cytosine)methyl-6-oxo-3,4-dimercapto-pteridino[6,7-5,6]pyranoato-S3,S4]-cysteinyl-S-copper-mu-sulfido-molybdenum hydroxide oxide RESID-systematic copper sulfido molybdopterin cytosine dinuncleotide UniMod-description CuSMo PSI-MS-label cysteinyl copper mu-sulfido Mo-pterin cytosine dinucleotide RESID-alternate L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide RESID-name DiffAvg 922.07 DiffFormula C 19 Cu 1 H 24 Mo 1 N 8 O 15 P 2 S 3 DiffMono 922.834854 Formula C 22 Cu 1 H 29 Mo 1 N 9 O 16 P 2 S 4 MassAvg 1025.20 MassMono 1025.844039 Origin C Source natural TermSpec none MOD:00742 MOD:00744 MOD:00860 MOD:00905 PSI-MOD MOD:00361 tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an S-adenosylmethionine and a four-iron four-sulfur cluster to tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide. 11222759 PubMed 14704425 PubMed AA0356 RESID Cross-link 3. METAL Iron-sulfur (4Fe-4S-S-AdoMet) UniProt-feature tetra-mu3-sulfido(S-adenosylmethion-N,O-diyliron)tris(S-cysteinyliron) RESID-systematic tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide RESID-name DiffAvg 747.03 DiffFormula C 15 Fe 4 H 19 N 6 O 5 S 5 DiffMono 746.742346 FormalCharge 1- Formula C 24 Fe 4 H 34 N 9 O 8 S 8 MassAvg 1056.45 MassMono 1055.769901 Origin C, C, C Source natural TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:00362 tris-L-cysteinyl L-arginyl diiron disulfide A protein modification that effectively converts three L-cysteine residues, an L-arginine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-arginyl diiron disulfide. 14704425 PubMed AA0357 RESID Cross-link 4. di-mu-sulfido(N(eta1)-arginyl-S-cysteinyliron)(bis-S-cysteinyliron) RESID-systematic METAL Iron-sulfur (2Fe-2S) UniProt-feature tris-L-cysteinyl L-arginyl diiron disulfide RESID-name DiffAvg 172.79 DiffFormula C 0 Fe 2 H -3 N 0 O 0 S 2 DiffMono 172.791639 FormalCharge 2- Formula C 15 Fe 2 H 24 N 7 O 4 S 5 MassAvg 638.39 MassMono 637.920304 Origin C, C, C, R Source natural TermSpec none MOD:00739 MOD:00902 MOD:00905 PSI-MOD MOD:00363 L-cysteinyl-L-selenocysteine (Cys-Sec) A protein modification that effectively cross-links an L-cysteine residue and an L-selenocysteine residues to form L-cysteinyl-L-selenocystine. 12911312 PubMed AA0358#SEC RESID Cross-link 2. PSI-MOD-slim (R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid RESID-systematic CROSSLNK Cysteinyl-selenocysteine (Cys-Sec) UniProt-feature CROSSLNK Cysteinyl-selenocysteine (Sec-Cys) UniProt-feature L-cysteinyl-L-selenocysteine RESID-name DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 Se 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 2 S 1 Se 1 MassAvg 251.17 MassMono 251.947170 Origin C, U Source natural TermSpec none MOD:01158 MOD:01627 PSI-MOD MOD:00364 5-hydroxy-N6,N6,N6-trimethyl-L-lysine A protein modification that effectively converts an L-lysine residue to 5-hydroxy-N6,N6,N6-trimethyl-L-lysine. 11349130 PubMed 14661085 PubMed AA0359 RESID 445#K UniMod Incidental to RESID:AA0278; secondary to RESID:AA0028; secondary to RESID:AA0074. (2R,5Xi)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentan-1-aminium RESID-systematic (2Xi,5S)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentanaminium RESID-alternate (2Xi,5S)-5-azanyl-5-carboxy-2-hydroxy-N,N,N-trimethylpentanazanium RESID-alternate 5-hydroxy-N(zeta)-trimethyllysine RESID-alternate 5-hydroxy-N6,N6,N6-trimethyl UniMod-description 5-hydroxy-N6,N6,N6-trimethyl-L-lysine RESID-name 5-hydroxy-N6,N6,N6-trimethyllysin-N6-ium RESID-alternate 5-hydroxy-N6,N6,N6-trimethyllysine cation RESID-alternate 5-hydroxylated N6,N6,N6-trimethylated L-lysine PSI-MOD-alternate 5HyN6Me3Lys PSI-MOD-label alpha-amino-epsilon-dimethylamino-delta-hydroxycaproic acid RESID-alternate delta-hydroxy-epsilon-N,N,N-trimethyllysine RESID-alternate Hydroxytrimethyl PSI-MS-label lysine derivative Lys(z) RESID-alternate MOD_RES N6,N6,N6-trimethyl-5-hydroxylysine UniProt-feature DiffAvg 59.09 DiffFormula C 3 H 7 N 0 O 1 DiffMono 59.049141 FormalCharge 1+ Formula C 9 H 19 N 2 O 2 MassAvg 187.26 MassMono 187.144104 Origin K Source natural TermSpec none MOD:00602 MOD:00912 has_functional_parent MOD:000370 has_functional_parent MOD:000830 PSI-MOD MOD:00365 N-(L-isoglutamyl)-glycine A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoglutamyl)-glycine. 14531691 PubMed AA0360 RESID Cross-link 2. (S)-2-amino-5-(carboxymethyl)amino-5-oxopentanoic acid RESID-systematic 2-amino-N5-(carboxymethyl)-pentanediamic acid RESID-alternate CROSSLNK Isoglutamyl glycine isopeptide (Gly-Glu) UniProt-feature isoglutamyl glycine RESID-alternate N-(L-isoglutamyl)-glycine RESID-name N-gamma-glutamylglycine RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 7 H 9 N 2 O 3 MassAvg 169.16 MassMono 169.061317 Origin E, G Source natural TermSpec N-term MOD:00688 MOD:00906 MOD:00908 MOD:00954 PSI-MOD MOD:00366 O-sulfo-L-serine A protein modification that effectively converts an L-serine residue to O-sulfo-L-serine. 14752058 PubMed AA0361 RESID 40#S UniMod PSI-MOD-slim (2S)-2-amino-3-(sulfooxy)propanoic acid RESID-systematic 2-amino-3-hydroxypropanoic acid 3-sulfate RESID-alternate MOD_RES Sulfoserine UniProt-feature O-sulfo-L-serine RESID-name O-Sulfonation UniMod-description O3-sulfonoserine RESID-alternate O3-sulfoserine RESID-alternate serine sulfate ester RESID-alternate Sulfo PSI-MS-label DiffAvg 80.06 DiffFormula C 0 H 0 N 0 O 3 S 1 DiffMono 79.956815 Formula C 3 H 5 N 1 O 5 S 1 MassAvg 167.13 MassMono 166.988843 Origin S Source natural TermSpec none MOD:00695 MOD:00771 MOD:00916 PSI-MOD MOD:00367 O-sulfo-L-threonine A protein modification that effectively converts an L-threonine residue to O-sulfo-L-threonine. 14752058 PubMed AA0362 RESID 40#T UniMod PSI-MOD-slim (2S,3R)-2-amino-3-(sulfooxy)butanoic acid RESID-systematic 2-amino-3-hydroxybutanoic acid 3-sulfate RESID-alternate MOD_RES Sulfothreonine UniProt-feature O-sulfo-L-threonine RESID-name O-Sulfonation UniMod-description O3-sulfonothreonine RESID-alternate O3-sulfothreonine RESID-alternate Sulfo PSI-MS-label threonine sulfate ester RESID-alternate DiffAvg 80.06 DiffFormula C 0 H 0 N 0 O 3 S 1 DiffMono 79.956815 Formula C 4 H 7 N 1 O 5 S 1 MassAvg 181.16 MassMono 181.004493 Origin T Source natural TermSpec none MOD:00695 MOD:00773 MOD:00917 PSI-MOD MOD:00368 N-carboxy-L-methionine A protein modification that effectively converts an L-methionine residue to N-carboxy-L-methionine. 10368287 PubMed 11120890 PubMed 12595263 PubMed 8312270 PubMed AA0363 RESID 299#M UniMod At least three protein crystallographic structures have been reported with this modification. However, no chemical evidence for this modification is provided, there were no reports of this modification before these crystallographic reports, and there is no metabolic explanation for the conversion of a formyl group to a carboxy group. There is confusion in its description, and misnaming is common. This modification is probably a misidentification of N-(dihydroxymethyl)methionine, the hydrated form of N-formylmethionine. See MOD:01446 [JSG]. (S)-2-carboxyamino-4-(methylsulfanyl)butanoic acid RESID-systematic 2-carbamic-4-(methylsulfanyl)butanoic acid RESID-alternate 2-carbamic-4-(methylthio)butanoic acid RESID-alternate Carboxy UniMod-interim Carboxylation UniMod-description N-carboxy-L-methionine RESID-name N-carboxymethionine RESID-alternate DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 S 0 DiffMono 43.989829 Formula C 6 H 10 N 1 O 3 S 1 MassAvg 176.21 MassMono 176.038139 Origin M Source hypothetical TermSpec N-term MOD:00913 MOD:01152 PSI-MOD MOD:00369 O-acetyl-L-serine A protein modification that effectively converts an L-serine residue to O-acetyl-L-serine. 17981 ChEBI 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 16731519 PubMed 489587 PubMed 7309355 PubMed AA0364 RESID 1#S UniMod incidental to RESID:AA0051 PSI-MOD-slim (2S)-3-(acetyloxy)-2-aminopropanoic acid RESID-systematic Acetyl PSI-MS-label Acetylation UniMod-description MOD_RES O-acetylserine UniProt-feature O-acetyl-L-serine RESID-name O-acetylated L-serine PSI-MOD-alternate O-acetylserine RESID-alternate OAcSer PSI-MOD-label serine acetate ester RESID-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin S Source natural TermSpec none MOD:00644 MOD:00647 PSI-MOD MOD:00370 (E)-2,3-didehydrotyrosine A protein modification that effectively converts an L-tyrosine residue to (E)-2,3-didehydrotyrosine. 12623015 PubMed AA0365 RESID incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 PSI-MOD-slim (2E)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid RESID-systematic (E)-2,3-didehydrogenated tyrosine PSI-MOD-alternate (E)-2,3-didehydrotyrosine RESID-name 2-amino-3-oxo-butanoic_acid UniMod-description amino-(para-hydroxybenzylidenyl)acetic acid RESID-alternate blue non-fluorescent pocilloporin chromophore RESID-alternate Didehydro PSI-MS-label E-dHTyr PSI-MOD-label MOD_RES (E)-2,3-didehydrotyrosine UniProt-feature para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate trans-dehydrotyrosine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 9 H 7 N 1 O 2 MassAvg 161.16 MassMono 161.047678 Origin Y Source natural TermSpec none MOD:00706 PSI-MOD MOD:00371 bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide A protein modification that effectively converts two L-aspartic acid residues, three L-glutamic acid residues, an L-histidine residue, and a one-calcium, four-iron, four-oxygen cluster to bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide. 14764885 PubMed AA0366 RESID Cross-link 6. 4Mn-Ca-4O cluster RESID-alternate bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide RESID-name mu3-1:2:3kappaO-oxido-mu3-1:3:4kappaO-oxido-mu3-2:3:4kappaO-oxido-mu4-1:2:4:5kappaO-oxido-N1'-histidino-O5-glutamato 2-manganese-O5,O5-glutamato 3-manganese-O4-aspartato 4-manganese-O4-aspartato-O5-glutamato 5-manganese RESID-systematic photosystem II catalytic cluster RESID-alternate DiffAvg 317.78 DiffFormula C 0 Ca 1 H -6 Mn 4 N 0 O 4 DiffMono 317.647480 Formula C 29 Ca 1 H 32 Mn 4 N 8 O 20 MassAvg 1072.44 MassMono 1071.888057 Origin D, D, E, E, E, H Source hypothetical TermSpec none MOD:00740 MOD:00904 MOD:00906 MOD:00909 MOD:01482 PSI-MOD MOD:00372 3'-(3'-L-tyrosinyl)-L-tyrosine A protein modification that effectively cross-links two L-tyrosine residues with a carbon-carbon bond to form 3'-(3'-L-tyrosinyl)-L-tyrosine. 0 DeltaMass 14249161 PubMed 637884 PubMed 8702710 PubMed 8937563 PubMed AA0367 RESID Cross-link 2; From DeltaMass: Average Mass: -2. (2S,2'S)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)bis(2-aminopropanoic acid) RESID-systematic 3'-(L-tyros-3'-yl)-L-tyrosine RESID-name 3,3'-BiTyr (Crosslink) DeltaMass-label 6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-bis(2-aminopropanoic acid) RESID-alternate alpha,alpha'-diamino-6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-dipropanoic acid RESID-alternate bityrosine RESID-alternate o,o-dityrosine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 18 H 16 N 2 O 4 MassAvg 324.34 MassMono 324.111007 Origin Y, Y Source natural TermSpec none MOD:00692 MOD:00919 PSI-MOD MOD:00373 3'-(O4'-L-tyrosinyl)-L-tyrosine A protein modification that effectively cross-links L-tyrosine residues with an ether bond to form 3'-(O4'-L-tyrosinyl)-L-tyrosine. 0 DeltaMass 12719529 PubMed 7115340 PubMed 8702710 PubMed AA0368 RESID Cross-link 2; secondary to RESID:AA0146; From DeltaMass: Average Mass: -2. (2S)-2-amino-3-[3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-4-hydroxyphenyl]propanoic acid RESID-systematic 2-amino-3-[4-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenoxy)phenyl]propanoic acid RESID-alternate 3'-(L-tyros-O4'-yl)-L-tyrosine RESID-name CROSSLNK Isodityrosine (Tyr-Tyr) UniProt-feature IsodiTyr (Crosslink) DeltaMass-label isodityrosine RESID-alternate O-(5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)-L-tyrosine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 18 H 16 N 2 O 4 MassAvg 324.34 MassMono 324.111007 Origin Y, Y Source natural TermSpec none MOD:00692 MOD:00919 PSI-MOD MOD:00374 3,4-dihydroxy-L-arginine A protein modification that effectively converts an L-arginine residue to 3,4-dihydroxy-L-arginine. 10978343 PubMed 12686488 PubMed AA0369 RESID 425#R UniMod (2S,3Xi,4Xi)-2-amino-5-carbamimidamido-3,4-dihydroxypentanoic acid RESID-systematic 2-amino-5-guanidino-3,4-dihydroxypentanoic acid RESID-alternate 3,4-dihydroxy-L-arginine RESID-name 3,4-dihydroxylated L-arginine PSI-MOD-alternate 34Hy2Arg PSI-MOD-label beta,gamma-dihydroxyarginine RESID-alternate dihydroxy UniMod-description Dioxidation PSI-MS-label MOD_RES 3,4-dihydroxyarginine UniProt-feature DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 6 H 12 N 4 O 3 MassAvg 188.19 MassMono 188.090940 Origin R Source natural TermSpec none MOD:00428 MOD:00682 PSI-MOD MOD:00375 4,5-dihydroxy-L-lysine A protein modification that effectively converts an L-lysine residue to 4,5-dihydroxy-L-lysine. 10978343 PubMed 12686488 PubMed AA0370 RESID 425#K UniMod (2S,4Xi,5Xi)-2,6-diamino-4,5-dihydroxyhexanoic acid RESID-systematic 4,5-dihydroxy-L-lysine RESID-name 4,5-dihydroxylated L-lysine PSI-MOD-alternate 45Hy2Lys PSI-MOD-label alpha,epsilon-diamino-delta,gamma-dihydroxycaproic acid RESID-alternate delta,gamma-dihydroxylysine RESID-alternate dihydroxy UniMod-description Dioxidation PSI-MS-label MOD_RES 4,5-dihydroxylysine UniProt-feature DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 6 H 12 N 2 O 3 MassAvg 160.17 MassMono 160.084792 Origin K Source natural TermSpec none MOD:00428 MOD:00681 PSI-MOD MOD:00376 1'-(phospho-5'-adenosine)-L-histidine A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form 1'-(phospho-5'-adenosine)-L-histidine. 15182206 PubMed 9323207 PubMed AA0371 RESID 405#H UniMod PSI-MOD-slim (2S)-2-amino-3-[1-(5'-adenosine phosphono)imidazol-4-yl]propanoic acid RESID-systematic 1'-(phospho-5'-adenosine)-L-histidine RESID-name ACT_SITE Tele-AMP-histidine intermediate UniProt-feature AMP binding site UniMod-description L-histidine 5'-adenosine phosphoramidester RESID-alternate L-histidine monoanhydride with 5'-adenylic acid RESID-alternate N(tau)-5'-adenylic-L-histidine RESID-alternate N1'-adenylylated histidine RESID-alternate Phosphoadenosine PSI-MS-label tele-5'-adenylic-L-histidine RESID-alternate DiffAvg 329.21 DiffFormula C 10 H 12 N 5 O 6 P 1 DiffMono 329.052520 Formula C 16 H 19 N 8 O 7 P 1 MassAvg 466.35 MassMono 466.111432 Origin H Source natural TermSpec none MOD:00909 MOD:01165 PSI-MOD MOD:00377 1'-(phospho-5'-uridine)-L-histidine A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphouridine through a phosphoramide ester bond to form 1'-(phospho-5'-uridine)-L-histidine. 11467524 PubMed 321007 PubMed 380639 PubMed 8794735 PubMed AA0372 RESID 417#H UniMod PSI-MOD-slim (S)-2-amino-3-[1-(5'-uridine phosphono)imidazol-4-yl]propanoic acid RESID-systematic 1'-(phospho-5'-uridine)-L-histidine RESID-name ACT_SITE Tele-UMP-histidine intermediate UniProt-feature L-histidine 5'-uridine phosphoramidester RESID-alternate L-histidine monoanhydride with 5'-uridylic acid RESID-alternate N(tau)-5'-uridylic-L-histidine RESID-alternate N1'-uridylylated histidine RESID-alternate PhosphoUridine PSI-MS-label tele-5'-uridylic-L-histidine RESID-alternate uridine phosphodiester UniMod-description DiffAvg 306.17 DiffFormula C 9 H 11 N 2 O 8 P 1 DiffMono 306.025302 Formula C 15 H 18 N 5 O 9 P 1 MassAvg 443.31 MassMono 443.084214 Origin H Source natural TermSpec none MOD:00909 MOD:01166 PSI-MOD MOD:00378 L-aspartyl semialdehyde A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl semialdehyde. 1093385 PubMed 14235557 PubMed 15237995 PubMed AA0373 RESID 447#D UniMod PSI-MOD-slim (S)-2-amino-4-oxobutanoic acid RESID-systematic aspartyl 4-semialdehyde PSI-MOD-alternate aspartyl aldehyde PSI-MOD-alternate Deoxy PSI-MS-label L-aminosuccinaldehydic acid RESID-alternate L-aminosuccinic acid semialdehyde RESID-alternate L-aspartate-beta-semialdehyde RESID-alternate L-aspartic beta-semialdehyde RESID-alternate L-aspartyl aldehyde RESID-name L-beta-formylalanine RESID-alternate MOD_RES Aspartyl aldehyde UniProt-feature reduction UniMod-description DiffAvg -16.00 DiffFormula C 0 H 0 N 0 O -1 DiffMono -15.994915 Formula C 4 H 5 N 1 O 2 MassAvg 99.09 MassMono 99.032028 Origin D Source natural TermSpec none MOD:00904 MOD:01161 PSI-MOD MOD:00379 L-serine microcin E492 siderophore ester A protein modification that effectively converts an L-serine residue to L-serine microcin E492 siderophore ester. 15102848 PubMed AA0374 RESID 448#C-term UniMod UniMod origin corrected [JSG]. L-serine microcin E492 siderophore ester RESID-name Microcin PSI-MS-label microcin E492 siderophore ester from serine UniMod-description MOD_RES Serine microcin E492 siderophore ester UniProt-feature N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine RESID-systematic DiffAvg 831.69 DiffFormula C 36 H 37 N 3 O 20 DiffMono 831.197041 Formula C 39 H 43 N 4 O 23 MassAvg 935.78 MassMono 935.231809 Origin S Source natural TermSpec C-term MOD:00916 PSI-MOD MOD:00380 L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide). 12910261 PubMed 14725769 PubMed AA0375 RESID 424#D UniMod 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide RESID-alternate bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-aspartyl-molybdenum RESID-systematic L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) RESID-name molybdenum bis(molybdopterin guanine dinucleotide) UniMod-description MolybdopterinGD PSI-MS-label nitrate reductase A aspartyl Mo-bisMGD cofactor RESID-alternate phosphoric acid 4-(2-amino-4-oxo-3,4,5,6,-tetrahydro-pteridin-6-yl)-2-hydroxy-3,4-dimercapto-but-3-en-yl ester guanylate ester RESID-alternate DiffAvg 1572.02 DiffFormula C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 DiffMono 1572.985775 Formula C 44 H 52 Mo 1 N 21 O 29 P 4 S 4 MassAvg 1687.10 MassMono 1688.012718 Origin D Source natural TermSpec none MOD:00904 MOD:01167 PSI-MOD MOD:00381 L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Sec) A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide). 11372198 PubMed 12220497 PubMed AA0376#SEC RESID DiffAvg 1691.97 DiffFormula C 40 H 47 N 20 O 26 P 4 S 5 Se 0 W 1 DiffMono 1691.003369 Formula C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1 MassAvg 1842.02 MassMono 1841.957004 Origin U Source natural TermSpec none MOD:00746 MOD:00748 MOD:01158 PSI-MOD MOD:00382 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one A protein modification that effectively crosslinks an L-methionyl-L-tyrosine dipeptide to form 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one. 10852900 PubMed 11259412 PubMed 15491166 PubMed AA0377 RESID carboxamidine; cross-link 1. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. 3-(2-methylsulfanyl)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one RESID-systematic 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-amino-3,6-didehydropyrazin-2-ol RESID-alternate 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one RESID-name GFP-like chromoprotein asFP595 chromophore RESID-alternate L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine RESID-alternate DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 14 H 15 N 2 O 2 S 1 MassAvg 275.35 MassMono 275.085424 Origin M, Y Source hypothetical TermSpec N-term MOD:00913 MOD:00919 PSI-MOD MOD:00383 2-imino-glutamic acid 5-imidazolinone glycine A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue to form 2-imino-glutamic acid 5-imidazolinone glycine. 11682051 PubMed AA0378 RESID Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. 2,N-didehydroglutamyl-5-imidazolinone glycine RESID-alternate 2-(3-carboxy-1-iminopropyl)-1-carboxymethyl-1-imidazolin-5-one RESID-alternate 2-imino-glutamic acid 5-imidazolinone glycine RESID-name 2-imino-glutamyl-5-imidazolinone glycine RESID-alternate 4-[1-(carboxymethyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-iminobutanoic acid RESID-systematic [2-(3-carboxy-1-iminopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid RESID-alternate CROSSLNK 2-iminomethyl-5-imidazolinone (Glu-Gly) UniProt-feature para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 DiffMono -20.026215 Formula C 7 H 6 N 2 O 3 MassAvg 166.14 MassMono 166.037842 Origin E, G Source hypothetical TermSpec none MOD:00906 MOD:00908 MOD:01882 PSI-MOD MOD:00384 2-imino-methionine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-methionine residue and a glycine residue to form 2-imino-methionine 5-imidazolinone glycine. 10852900 PubMed 12185250 PubMed 12909624 PubMed 15542608 PubMed AA0379 RESID Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. (2-[1-imino-3-(methylsulfanyl)propyl]-5-oxo-4,5-dihydro-imidazol-1-yl)acetic acid RESID-alternate (2-[3-(methylsulfanyl)propanimidoyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid RESID-systematic 2,N-didehydromethionyl-5-imidazolinone glycine RESID-alternate 2-[1-imino-3-(methylsulfanyl)propyl]-1-carboxymethyl-1-imidazolin-5-one RESID-alternate 2-imino-methionine 5-imidazolinone glycine RESID-name 2-imino-methionyl-5-imidazolinone glycine RESID-alternate CROSSLNK 2-iminomethyl-5-imidazolinone (Met-Gly) UniProt-feature GFP-like chromoprotein asFP595 chromophore RESID-alternate para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate red fluorescent protein eqFP611 chromophore RESID-alternate DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 7 H 8 N 2 O 1 S 1 MassAvg 168.21 MassMono 168.035734 Origin G, M Source natural TermSpec none MOD:00908 MOD:00913 MOD:01882 PSI-MOD MOD:00385 L-asparagine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue to form L-asparagine 5-imidazolinone glycine. 10504696 PubMed AA0380 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. (2-[(1S)-1,3-diamino-3-oxopropyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid RESID-systematic 2-[(S)-1,3-diamino-3-oxopropyl]-1-carboxymethyl-1-imidazolin-5-one RESID-alternate [2-(1,3-diamino-3-oxopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid RESID-alternate asparaginyl-5-imidazolinone glycine RESID-alternate CROSSLNK 5-imidazolinone (Asn-Gly) UniProt-feature L-asparagine 5-imidazolinone glycine RESID-name para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate Zoanthus sp. fluorescent protein FP506 chromophore RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 6 H 7 N 3 O 2 MassAvg 153.14 MassMono 153.053826 Origin G, N Source hypothetical TermSpec none MOD:00903 MOD:00908 MOD:01882 PSI-MOD MOD:00386 L-lysine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form L-lysine 5-imidazolinone glycine. 10504696 PubMed AA0381 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. (2-[(1S)-1,5-diaminopentyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid RESID-systematic 2-[(S)-1,5-diaminopentanyl]-1-carboxymethyl-1-imidazolin-5-one RESID-alternate [2-(1,5-diaminopentanyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid RESID-alternate Anemonia majano fluorescent protein FP486 chromophore RESID-alternate CROSSLNK 5-imidazolinone (Lys-Gly) UniProt-feature L-lysine 5-imidazolinone glycine RESID-name lysyl-5-imidazolinone glycine RESID-alternate para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 8 H 13 N 3 O 1 MassAvg 167.21 MassMono 167.105862 Origin G, K Source hypothetical TermSpec none MOD:00908 MOD:00912 MOD:01882 PSI-MOD MOD:00387 2-tetrahydropyridinyl-5-imidazolinone glycine A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form 2-tetrahydropyridinyl-5-imidazolinone glycine. 10504696 PubMed 15628861 PubMed AA0382 RESID Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. 2-(3,4,5,6-tetrahydropyridin-2-yl)-1-carboxymethyl-1-imidazolin-5-one RESID-alternate 2-(tetrahydropyrid-2-yl)-5-imidazolinone glycine RESID-alternate 2-tetrahydropyridinyl-5-imidazolinone glycine RESID-name [5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid RESID-alternate [5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid RESID-systematic CROSSLNK 2-tetrahydro-2-pyridyl-5-imidazolinone (Lys-Gly) UniProt-feature para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate Zoanthus sp. fluorescent protein zFP538 chromophore RESID-alternate DiffAvg -37.06 DiffFormula C 0 H -7 N -1 O -1 DiffMono -37.052764 Formula C 8 H 9 N 2 O 1 MassAvg 149.17 MassMono 149.071488 Origin G, K Source natural TermSpec N-term MOD:00908 MOD:00912 MOD:01882 PSI-MOD MOD:00388 L-alanyl-pentaglycyl-murein peptidoglycan A protein modification that effectively attaches an L-alanine residue to murein peptidoglycan by a pentaglycine linker peptide. 8163519 PubMed AA0383 RESID (2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(alanyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine RESID-alternate L-alanyl-pentaglycyl-murein peptidoglycan RESID-name MOD_RES Pentaglycyl murein peptidoglycan amidated alanine UniProt-feature DiffAvg 268.25 DiffFormula C 10 H 14 N 5 O 4 DiffMono 268.104579 Formula C 13 H 20 N 6 O 6 MassAvg 356.34 MassMono 356.144432 Origin A Source hypothetical TermSpec C-term MOD:00901 MOD:01159 PSI-MOD MOD:00389 N-formyl-L-proline A protein modification that effectively converts an L-proline residue to N-formyl-L-proline. 12051774 PubMed 5464655 PubMed AA0384 RESID 122#N-term UniMod CAUTION - observations of this modification can be attributed to unintended artifactual production, or to spurious peptide MS identification. This modification is probably not a natural post-translational modification [JSG]. (2S)-1-formylpyrrolidine-2-carboxylic acid RESID-systematic 1-formyl-2-pyrrolidinecarboxylic acid RESID-alternate 1-formylproline RESID-alternate N-formyl-L-proline RESID-name N-formylated L-proline PSI-MOD-alternate NFoPro PSI-MOD-label DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 6 H 8 N 1 O 2 MassAvg 126.14 MassMono 126.055504 Origin P Source hypothetical TermSpec N-term MOD:00409 MOD:00915 MOD:01696 PSI-MOD MOD:00390 O-decanoyl-L-serine A protein modification that effectively converts an L-serine residue to O-decanoyl-L-serine. 12630926 PubMed AA0385 RESID 449#S UniMod (2S)-2-amino-3-(decanoyloxy)propanoic acid RESID-systematic Decanoyl PSI-MS-label L-serine decanoate ester RESID-alternate lipid UniMod-description LIPID O-decanoyl serine UniProt-feature O-decanoyl-L-serine RESID-name O-decanoylated L-serine PSI-MOD-alternate O3-decanoyl-L-serine RESID-alternate ODecSer PSI-MOD-label DiffAvg 154.25 DiffFormula C 10 H 18 N 0 O 1 DiffMono 154.135765 Formula C 13 H 23 N 1 O 3 MassAvg 241.33 MassMono 241.167794 Origin S Source natural TermSpec none MOD:00668 MOD:00916 PSI-MOD MOD:00391 O-octanoyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-octanoyl-L-threonine. 11546772 PubMed 12716131 PubMed AA0386 RESID 426#T UniMod PSI-MOD-slim (2S)-2-amino-3-(octanoyloxy)butanoic acid RESID-systematic L-threonine octanoate ester RESID-alternate LIPID O-octanoyl threonine UniProt-feature O-octanoyl-L-threonine RESID-name O-octanoylated L-threonine PSI-MOD-alternate O3-octanoyl-L-threonine RESID-alternate Octanoyl PSI-MS-label octanoyl UniMod-description OOctThr PSI-MOD-label DiffAvg 126.20 DiffFormula C 8 H 14 N 0 O 1 DiffMono 126.104465 Formula C 12 H 21 N 1 O 3 MassAvg 227.30 MassMono 227.152144 Origin T Source natural TermSpec none MOD:00669 MOD:00917 PSI-MOD MOD:00392 O-decanoyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-decanoyl-L-threonine. 11546772 PubMed AA0387 RESID 449#T UniMod (2S)-2-amino-3-(decanoyloxy)propanoic acid RESID-systematic Decanoyl PSI-MS-label L-threonine decanoate ester RESID-alternate lipid UniMod-description LIPID O-decanoyl threonine UniProt-feature O-decanoyl-L-threonine RESID-name O-decanoylated L-threonine PSI-MOD-alternate O3-decanoyl-L-threonine RESID-alternate ODecThr PSI-MOD-label DiffAvg 154.25 DiffFormula C 10 H 18 N 0 O 1 DiffMono 154.135765 Formula C 14 H 25 N 1 O 3 MassAvg 255.36 MassMono 255.183444 Origin T Source natural TermSpec none MOD:00668 MOD:00917 PSI-MOD MOD:00393 O-methylated residue A protein modification that effectively replaces a hydroxyl group hydrogen with a methyl group to produce either an ether from an alcohol or an ester from an acid. 18688235 PubMed PSI-MOD-slim OMeRes PSI-MOD-label MOD:00427 PSI-MOD MOD:00394 acetylated residue A protein modification that effectively replaces a hydrogen atom with an acetyl group. 0 DeltaMass 11857757 PubMed 11999733 PubMed 12175151 PubMed 14730666 PubMed 15350136 PubMed 1 UniMod Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42 PSI-MOD-slim Acetyl PSI-MS-label Acetylation UniMod-description Acetylation (N terminus, N epsilon of Lysine, O of Serine) (Ac) DeltaMass-label AcRes PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 O 1 DiffMono 42.010565 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00649 PSI-MOD MOD:00395 thioester crosslinked residues A protein modification that crosslinks two residues by formation of a thioester bond between a cysteine thiol and either an alpha-carbonyl, as in S-(L-methionyl-L-cysteine), or a sidechain carbonyl, as in S-(L-isoglutamyl)-L-cysteine. 18688235 PubMed PSI-MOD-slim MOD:00033 MOD:00905 PSI-MOD MOD:00396 O-glycosylated residue A protein modification that effectively replaces a residue hydrogen atom on an oxygen with a carbohydrate-like group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim OGlycoRes PSI-MOD-label MOD:00693 PSI-MOD MOD:00397 iodoacetamide derivatized residue A protein modification that is produced by reaction with iodoacetamide, usually replacement of a reactive hydrogen with a methylcarboxamido group. 11327326 PubMed 11510821 PubMed 12422359 PubMed 4 UniMod PSI-MOD-slim Carbamidomethyl PSI-MS-label Iodoacetamide derivative UniMod-description DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00398 carbamoylated residue A protein modification that effectively replaces a hydrogen atom with a carbamoyl (carboxamido) group. Replacement of an amino hydrogen produces a ureido group. 56 DeltaMass 10978403 PubMed 12203680 PubMed 5 UniMod This modification can be produced by hydrogen cyanate, either used as a reagent or as released by urea degradation in solution [JSG]. PSI-MOD-slim Carbamyl UniMod-interim Carbamylation DeltaMass-label Carbamylation UniMod-description DiffAvg 43.02 DiffFormula C 1 H 1 N 1 O 1 DiffMono 43.005814 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:01156 PSI-MOD MOD:00399 iodoacetic acid derivatized residue A protein modification that is produced by reaction with iodoacetic acid, usually replacement of a reactive hydrogen with a methylcarboxy group. 64 DeltaMass 6 UniMod From DeltaMass: Average Mass: 58 Abbreviation:CmC Average Mass Change:58 Notes:Cysteine reacts with iodoacetic acid to produce carboxymethyl cysteine. PSI-MOD-slim Carboxymethyl PSI-MS-label Carboxymethyl (on Cysteine) DeltaMass-label Iodoacetic acid derivative UniMod-description DiffAvg 58.04 DiffFormula C 2 H 2 O 2 DiffMono 58.005479 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00400 deamidated residue A protein modification that effectively replaces a carboxamido group with a carboxyl group, with both a gain of oxygen and loss of a nitrogen and a hydrogen. 32 DeltaMass 7 UniMod From DeltaMass: References:Vish Katta. PSI-MOD-slim Deamidated PSI-MS-label Deamidation UniMod-description Deamidation of Asparagine and Glutamine to Aspartate and Glutamate DeltaMass-label deamidationkq OMSSA-label dNRes PSI-MOD-label DiffAvg 0.98 DiffFormula H -1 N -1 O 1 DiffMono 0.984016 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:01156 PSI-MOD MOD:00401 Gygi ICAT(TM) d0 modified cysteine A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d0 reagent. 10504701 PubMed 8#C UniMod Gygi ICAT(TM) d0 UniMod-description ICAT-G PSI-MS-label DiffAvg 486.63 DiffFormula C 22 H 38 N 4 O 6 S 1 DiffMono 486.251206 Formula C 25 H 43 N 5 O 7 S 2 MassAvg 589.77 MassMono 589.260391 Origin C Source artifact TermSpec none MOD:01426 MOD:01820 PSI-MOD MOD:00402 Gygi ICAT(TM) d8 modified cysteine A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d8 reagent. 10504701 PubMed 9#C UniMod Gygi ICAT(TM) d8 UniMod-description ICAT-G:2H(8) PSI-MS-label DiffAvg 494.30 DiffFormula C 22 (1)H 30 (2)H 8 N 4 O 6 S 1 DiffMono 494.301420 Formula C 25 (1)H 35 (2)H 8 N 5 O 7 S 2 MassAvg 597.31 MassMono 597.310605 Origin C Source artifact TermSpec none MOD:01431 MOD:01820 PSI-MOD MOD:00403 homoserine A protein modification that effectively converts an L-methionine residue to homoserine. 113 DeltaMass 10#M UniMod Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group and the following residue amino group. PSI-MOD-slim ctermpephsem OMSSA-label Homoserine UniMod-description Homoserine formed from Met by CNBr treatment DeltaMass-label Met->Hse PSI-MS-label DiffAvg -30.09 DiffFormula C -1 H -2 O 1 S -1 DiffMono -29.992806 Formula C 4 H 7 N 1 O 2 MassAvg 101.10 MassMono 101.047678 Origin M Source artifact TermSpec C-term MOD:00913 PSI-MOD MOD:00404 homoserine lactone A protein modification that effectively converts an L-methionine residue to homoserine lactone. 90 DeltaMass 11#M UniMod Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group. Under acid conditions the homoserine dehydrates to form the cyclic lactone. PSI-MOD-slim ctermpephselactm OMSSA-label Homoserine lactone UniMod-description Met->Hsl UniMod-interim DiffAvg -48.10 DiffFormula C -1 H -4 S -1 DiffMono -48.003371 Formula C 4 H 5 N 1 O 1 MassAvg 83.09 MassMono 83.037114 Origin M Source artifact TermSpec C-term MOD:00601 MOD:00913 PSI-MOD MOD:00405 Applied Biosystems original ICAT(TM) d8 modified cysteine A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d8 reagent. 12#C UniMod PSI-MOD-slim Applied Biosystems original ICAT(TM) d8 UniMod-description ICAT-D:2H(8) PSI-MS-label DiffAvg 450.28 DiffFormula C 20 (1)H 26 (2)H 8 N 4 O 5 S 1 DiffMono 450.275205 Formula C 23 (1)H 31 (2)H 8 N 5 O 6 S 2 MassAvg 553.28 MassMono 553.284390 Origin C Source artifact TermSpec none MOD:01431 MOD:01820 PSI-MOD MOD:00406 Applied Biosystems original ICAT(TM) d0 modified cysteine A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d0 reagent. 13#C UniMod PSI-MOD-slim Applied Biosystems original ICAT(TM) d0 UniMod-description ICAT-D PSI-MS-label DiffAvg 442.22 DiffFormula C 20 (1)H 34 N 4 O 5 S 1 DiffMono 442.224991 Formula C 23 (1)H 39 N 5 O 6 S 2 MassAvg 545.23 MassMono 545.234176 Origin C Source artifact TermSpec none MOD:01426 MOD:01820 PSI-MOD MOD:00407 residue methyl ester A protein modification that effectively replaces a carboxyl group with a carboxy methyl ester group. OBSOLETE because UniMod:14 merged with entry 34, remap to MOD:00599. 14 merged with entry 34 UniMod 18688235 PubMed ResOMe PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 DiffMono 14.015650 Formula none MassAvg none MassMono none Origin X Source none TermSpec none 1 PSI-MOD MOD:00408 N-acetylated residue A protein modification that effectively replaces a residue amino or imino hydrogen with an acetyl group. 18688235 PubMed PSI-MOD-slim N-Acetyl PSI-MOD-alternate N-Acetylation PSI-MOD-alternate NAcRes PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 O 1 DiffMono 42.010565 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00394 MOD:00670 PSI-MOD MOD:00409 N-formylated residue A protein modification that effectively replaces a residue amino group with a formamido group. PSI-MOD-slim Formyl PSI-MS-label NFoRes PSI-MOD-label ntermformyl OMSSA-label ntermpepformyl OMSSA-label DiffAvg 28.01 DiffFormula C 1 O 1 DiffMono 27.994915 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00493 MOD:00670 PSI-MOD MOD:00410 S-(N-isopropylcarboxamidomethyl)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(N-isopropylcarboxamidomethyl)-L-cysteine. 11465505 PubMed 8465942 PubMed 17#C UniMod N-isopropylcarboxamidomethyl UniMod-description NIPCAM PSI-MS-label nipcam OMSSA-label DiffAvg 99.13 DiffFormula C 5 H 9 N 1 O 1 S 0 DiffMono 99.068414 Formula C 8 H 14 N 2 O 2 S 1 MassAvg 202.27 MassMono 202.077599 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00411 O18 label modification from UniMod Isotopic label. OBSOLETE because UniMod:18 is now merged with entry 258 remap to MOD:00581 'single 018 label' 18 is now merged with entry 258 remap to MOD:00581 'single 018 label'" [PubMed:18688235 UniMod A modification from UniMod:18 DiffAvg 2.00 DiffFormula (16)O -1 (18)O 1 DiffMono 2.004246 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none 1 PSI-MOD MOD:00412 oxidation modification from UniMod artifact. OBSOLETE because UniMod entry 19 is now merged with UniMod 35 remap to MOD:00425 'monohydroxylated residue'. 18688235 PubMed DiffAvg 16.00 DiffFormula O 1 DiffMono 15.994915 Formula none MassAvg none MassMono none Origin X Source none TermSpec none 1 PSI-MOD MOD:00413 biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine A protein modification that is produced by reaction of a cysteine residue with biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine. 20#C UniMod Biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine UniMod-description PEO-Iodoacetyl-LC-Biotin UniMod-interim DiffAvg 414.52 DiffFormula C 18 H 30 N 4 O 5 S 1 DiffMono 414.193691 Formula C 21 H 35 N 5 O 6 S 2 MassAvg 517.66 MassMono 517.202876 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00414 monomethylated L-arginine A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with one methyl group. 215 DeltaMass 34#R UniMod From DeltaMass: formula incorrect, N and O reversed PSI-MOD-slim Me1Arg PSI-MOD-label Methyl PSI-MS-label methylr OMSSA-label N-methyl Arginyl DeltaMass-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 14 N 4 O 1 MassAvg 170.22 MassMono 170.116761 Origin R Source none TermSpec none MOD:00599 MOD:00658 PSI-MOD MOD:00415 phosphorylation without neutral loss modification from UniMod - OBSOLETE because UniMod entry 22 is now merged with entry 21 remap to MOD:00696 'phosphorylated residue'. 18688235 PubMed DiffAvg 79.98 DiffFormula H 1 O 3 P 1 DiffMono 79.966331 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none 1 PSI-MOD MOD:00416 phosphorylation of an hydroxyl amino acid with prompt loss of phosphate A change resulting in an alteration of the measured molecular mass of a peptide or protein hydroxyl amino acid phosphorylated promptly followed by secondary loss of a neutral trihydrogen phosphate molecular fragment. 23 UniMod O4-phosphotyrosine does not lose phosphate by this mechanism. UniMod does not provide a citation for this particular modification [JSG]. PSI-MOD-slim Dehydrated UniMod-interim Dehydration UniMod-description DiffAvg -18.02 DiffFormula H -2 O -1 DiffMono -18.010565 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00432 MOD:00704 PSI-MOD MOD:00417 S-carboxamidoethyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-carboxamidoethyl-L-cysteine. 72 DeltaMass 1481983 PubMed 24#C UniMod From DeltaMass: References: Anal. Biochem. Vol 216 No. 1 p131 (citation not found) Notes: Residual acrylamide in SDS gels can label free cysteines to produce propionamido-Cys (also known as PAM-Cys) Acrylamide adduct UniMod-description PAM-Cys DeltaMass-label Propionamide PSI-MS-label Propionamide or Acrylamide adduct DeltaMass-label propionamidec OMSSA-label S-(3-amino-3-oxopropyl)cysteine PSI-MOD-alternate S-carbamoylethyl-L-cysteine PSI-MOD-alternate S-propanamide-L-cysteine PSI-MOD-alternate DiffAvg 71.08 DiffFormula C 3 H 5 N 1 O 1 S 0 DiffMono 71.037114 Formula C 6 H 10 N 2 O 2 S 1 MassAvg 174.22 MassMono 174.046299 Origin C Source artifact TermSpec none MOD:00905 PSI-MOD MOD:00418 pyridylacetylated residue A protein modification that effectively replaces a hydrogen atom with an (pyridin-3-yl)acetyl group. 9276974 PubMed 25 UniMod Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. Pyridylacetyl PSI-MS-label pyridylacetyl UniMod-description DiffAvg 119.12 DiffFormula C 7 H 5 N 1 O 1 DiffMono 119.037114 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00649 MOD:00848 PSI-MOD MOD:00419 (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid A protein modification that effectively converts an L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid. 336 DeltaMass 12643538 PubMed 26#C UniMod From DeltaMass: A secondary modification affecting peptides with S-carbamoylmethyl-L-cysteine (CamC) at the N-terminus. These exist in enzymatic digests of proteins that have been S-alkylated with iodoacetamide. Cyclization of N-terminal CamC gives a residue of (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid. Peptides in which this has occurred become more hydrophobic, and lose 17 Da from the N-terminal residue. (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid DeltaMass-label 5-oxothiomorpholine-3-carboxylic acid PSI-MOD-alternate Otc DeltaMass-label Pyro-carbamidomethyl UniMod-interim S-carbamoylmethylcysteine cyclization (N-terminus) DeltaMass-label S-carbamoylmethylcysteine cyclization (N-terminus) UniMod-description DiffAvg 40.02 DiffFormula C 2 H 0 N 0 O 1 S 0 DiffMono 39.994915 Formula C 5 H 6 N 1 O 2 S 1 MassAvg 144.17 MassMono 144.011924 Origin C Source artifact TermSpec N-term MOD:00601 MOD:00905 PSI-MOD MOD:00420 2-pyrrolidone-5-carboxylic acid (Glu) A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid. 16 DeltaMass 10214721 PubMed 1836357 PubMed 3473473 PubMed 8382902 PubMed AA0031#GLU RESID 27#E UniMod From DeltaMass: References: The conversion of glutamic acid to pyroglutamic was reported for the beta-amyloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52 [DeltaMass]. The modification in amyloid protein is probably an artifact of treatment with strong acid under anhydrous conditions. Peptides with N-terminal glutamic acid isolated from single cells of Aplysia neurons show partial conversion to pyroglutamic acid, possibly dependent on a temperature sensitive factor [JSG]. (2S)-5-oxo-2-pyrrolidinecarboxylic acid RESID-systematic 2-oxopyrrolidine-5-carboxylic acid RESID-alternate 2-pyrrolidone-5-carboxylic acid RESID-name 5-oxoproline RESID-alternate 5-oxopyrrolidine-2-carboxylic acid RESID-alternate 5-pyrrolidone-2-carboxylic acid RESID-alternate Glu->pyro-Glu PSI-MS-label MOD_RES Pyrrolidone carboxylic acid (Glu) UniProt-feature ntermpeppyroe OMSSA-label PCA RESID-alternate PyrGlu(Glu) PSI-MOD-label Pyro-glu from E UniMod-description pyroglutamic acid RESID-alternate Pyroglutamic Acid formed from Glutamic Acid DeltaMass-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 5 H 6 N 1 O 2 MassAvg 112.11 MassMono 112.039853 Origin E Source artifact TermSpec N-term MOD:00906 MOD:01048 PSI-MOD MOD:00421 C-glycosylated residue A protein modification that effectively replaces a residue hydrogen atom on a carbon with a carbohydrate-like group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim CGlycoRes PSI-MOD-label MOD:00693 PSI-MOD MOD:00422 alpha-amino morpholine-2-acetylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a morpholine-2-acetyl group. 10446193 PubMed 29#N-term UniMod The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. N-Succinimidyl-2-morpholine acetate UniMod-description N-succinimidylmorpholine-2-acetate alpha-amino derivative PSI-MOD-alternate SMA PSI-MS-label DiffAvg 127.14 DiffFormula C 6 H 9 N 1 O 2 DiffMono 127.063329 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01696 MOD:01813 PSI-MOD MOD:00423 monosodium salt A protein modification that effectively substitutes one sodium atom for one hydrogen atom. 0 DeltaMass 30 UniMod PSI-MOD-slim Cation:Na PSI-MS-label Na1Res PSI-MOD-label Sodium DeltaMass-label Sodium adduct UniMod-description DiffAvg 21.98 DiffFormula H -1 Na 1 DiffMono 21.981944 Formula none MassAvg none MassMono none Origin X TermSpec none MOD:00747 PSI-MOD MOD:00424 S-pyridylethyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-pyridylethyl-L-cysteine. 253 DeltaMass 11760118 PubMed 626389 PubMed 8297018 PubMed 8783016 PubMed 31#C UniMod From DeltaMass: Formula:C10H12O2N1S1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:208.067 Average Mass Change:208.286 (mass incorrect, aggregate not delta) References:PE Sciex PECys DeltaMass-label Pyridylethyl PSI-MS-label Pyridylethyl Cystenyl DeltaMass-label S-pyridinylethyl-L-cysteine PSI-MOD-alternate S-pyridylethylation UniMod-description spyridylethylc OMSSA-label vinylpyridine derivatized cysteine residue PSI-MOD-alternate DiffAvg 105.14 DiffFormula C 7 H 7 N 1 DiffMono 105.057849 Formula C 10 H 12 N 2 O 1 S 1 MassAvg 208.28 MassMono 208.067034 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00425 monohydroxylated residue A protein modification that effectively replaces one hydrogen atom with a hydroxyl group. 35 UniMod PSI-MOD-slim Hy1Res PSI-MOD-label Oxidation UniMod-interim Oxidation or Hydroxylation UniMod-description DiffAvg 16.00 DiffFormula O 1 DiffMono 15.994915 Formula none MassAvg none MassMono none Origin X Source none TermSpec C-term MOD:00677 PSI-MOD MOD:00426 S-glycosylated residue A protein modification that effectively replaces a residue hydrogen atom on a sulfur with a carbohydrate-like group through a glycosidic bond. 18688235 PubMed SGlycoRes PSI-MOD-label MOD:00693 PSI-MOD MOD:00427 methylated residue A protein modification that effectively replaces a hydrogen atom with a methyl group. 36 DeltaMass From DeltaMass: Average Mass: 14 Average Mass Change:14 References:Methylation of Asparagine (found in phycobiliproteins) Klotz and Glazer (1987) J. Biol. Chem. 262; 17350-17355 PSI-MOD-slim MeRes PSI-MOD-label Methylation (N terminus, N epsilon of Lysine, O of Serine, Threonine or C terminus, N of Asparagine) DeltaMass-label MOD:00001 PSI-MOD MOD:00428 dihydroxylated residue A protein modification that effectively replaces two hydrogen atoms with two hydroxyl groups. 12686488 PubMed 425 UniMod PSI-MOD-slim dihydroxy UniMod-description Dioxidation PSI-MS-label Hy2Res PSI-MOD-label DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00677 PSI-MOD MOD:00429 dimethylated residue A protein modification that effectively replaces two hydrogen atoms with two methyl groups. 0 DeltaMass 12964758 PubMed 14570711 PubMed 36 UniMod For amino-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts only for dimethylation and not protonation. The alternative Me2+Res process accounts for both protonation and dimethylation [JSG]. PSI-MOD-slim di-Methylation UniMod-description Dimethyl PSI-MS-label Me2Res PSI-MOD-label N,N dimethylation (of Arginine or Lysine) DeltaMass-label DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00427 PSI-MOD MOD:00430 trimethylated residue A protein modification that effectively replaces three hydrogen atoms with three methyl groups. 12590383 PubMed 3145979 PubMed 4304194 PubMed 6778808 PubMed 7093227 PubMed 8453381 PubMed 37 UniMod For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative Me3+Res process accounts for both protonation and trimethylation. PSI-MOD-slim Me3Res PSI-MOD-label tri-Methylation UniMod-description Trimethyl PSI-MS-label DiffAvg 42.08 DiffFormula C 3 H 6 DiffMono 42.046950 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00427 PSI-MOD MOD:00431 modified residue with a secondary neutral loss Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral molecular fragment. 18688235 PubMed PSI-MOD-slim NLModRes PSI-MOD-label MOD:01157 PSI-MOD MOD:00432 modified residue with neutral loss of phosphate Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment. 18688235 PubMed PSI-MOD-slim dPhosModRes PSI-MOD-label MOD:00431 PSI-MOD MOD:00433 glucosylated residue A protein modification that effectively replaces a hydrogen atom with an glucose group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim GlcRes PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00434 MOD:00726 PSI-MOD MOD:00434 hexosylated residue A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexose sugar group through a glycosidic bond. 203 DeltaMass 15279557 PubMed 41 UniMod From DeltaMass: Average Mass: 162 Formula:C6 H10 05 Monoisotopic Mass Change:162.053 Average Mass Change:162.143 References:PE Sciex. PSI-MOD-slim Hex PSI-MOD-label Hex PSI-MS-label Hexose UniMod-description Hexoses (Fru, Gal, Glc, Man) DeltaMass-label O-Glycosyl- DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00435 O-phospho-L-serine with neutral loss of phosphate Covalent modification of a peptide or protein amino acid phosphorylated serine with a secondary loss of a neutral trihydrogen phosphate molecular fragment. 18688235 PubMed PSI-MOD-slim dPhosOPhosSer PSI-MOD-label DiffAvg -97.99 DiffFormula C 0 H -3 N 0 O -4 P -1 DiffMono -97.976895 Formula C 3 H 3 N 1 O 1 MassAvg 69.06 MassMono 69.021464 Origin MOD:00046 Source artifact TermSpec none MOD:01151 derives_from MOD:000460 PSI-MOD MOD:00436 N-acetylhexosaminylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylhexosamine group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim HexNAc PSI-MS-label HexNAc PSI-MOD-label N-Acetylhexosamine UniMod-description DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00693 PSI-MOD MOD:00437 farnesylated residue A protein modification that effectively replaces a hydrogen atom with a farnesyl group. 0 DeltaMass 15609361 PubMed 44 UniMod From DeltaMass: Average Mass: 204 PSI-MOD-slim Farnesyl PSI-MS-label Farnesylation DeltaMass-label Farnesylation UniMod-description FarnRes PSI-MOD-label DiffAvg 204.36 DiffFormula C 15 H 24 DiffMono 204.187801 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00703 PSI-MOD MOD:00438 myristoylated residue A protein modification that effectively replaces a hydrogen atom with a myristoyl group. 0 DeltaMass 45 UniMod From DeltaMass: Average Mass: 210 PSI-MOD-slim C14:0 aliphatic acylated residue PSI-MOD-alternate Myristoyl PSI-MS-label Myristoylation DeltaMass-label Myristoylation UniMod-description MyrRes PSI-MOD-label DiffAvg 210.36 DiffFormula C 14 H 26 O 1 DiffMono 210.198365 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00649 MOD:01155 PSI-MOD MOD:00439 O-phospho-L-threonine with neutral loss of phosphate Covalent modification of a peptide or protein amino acid phosphorylated threonine with a secondary loss of a neutral trihydrogen phosphate molecular fragment. 18688235 PubMed PSI-MOD-slim dPhosOPhosThr PSI-MOD-label DiffAvg -97.99 DiffFormula C 0 H -3 N 0 O -4 P -1 DiffMono -97.976895 Formula C 4 H 5 N 1 O 1 MassAvg 83.09 MassMono 83.037114 Origin MOD:00047 Source artifact TermSpec none MOD:00917 MOD:01151 derives_from MOD:000470 PSI-MOD MOD:00440 palmitoylated residue A protein modification that effectively replaces a hydrogen atom with a palmitoyl group. 0 DeltaMass From DeltaMass: Average Mass: 238 PSI-MOD-slim Palmitoyl PSI-MS-label Palmitoylation DeltaMass-label Palmitoylation UniMod-description PamRes PSI-MOD-label DiffAvg 238.41 DiffFormula C 16 H 30 O 1 DiffMono 238.229666 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00649 MOD:01155 PSI-MOD MOD:00441 geranylgeranylated residue A protein modification that effectively replaces a hydrogen atom with a geranylgeranyl group. 0 DeltaMass 15609361 PubMed 48 UniMod From DeltaMass: Average Mass: 272 PSI-MOD-slim Geranyl-geranyl UniMod-description GeranylGeranyl PSI-MS-label Geranylgeranylation DeltaMass-label GergerRes PSI-MOD-label DiffAvg 272.48 DiffFormula C 20 H 32 DiffMono 272.250401 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00703 PSI-MOD MOD:00442 protonated omega-N,omega-N'-dimethylated L-arginine with secondary neutral loss of N,N'-carbodiimide Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N'-dimethylated L-arginine with secondary loss of an N,N'-carbodiimide molecular fragment. 15835918 PubMed 18688235 PubMed dCDI-NNMe2+Arg PSI-MOD-label DiffAvg 42.04 DiffFormula C 1 H 2 N 2 O 0 DiffMono 42.021798 Formula C 7 H 14 N 2 O 1 MassAvg 142.20 MassMono 142.110613 Origin R Source artifact TermSpec none MOD:00431 MOD:00902 PSI-MOD MOD:00443 protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of N,N-dimethylamine Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of an N,N-dimethylamine molecular fragment. 15835918 PubMed 18688235 PubMed dDMA-NoMe2+Arg PSI-MOD-label DiffAvg 59.09 DiffFormula C 2 H 7 N 2 DiffMono 59.060923 Formula C 6 H 10 N 3 O 1 MassAvg 140.17 MassMono 140.082387 Origin R Source artifact TermSpec none MOD:00431 MOD:00902 PSI-MOD MOD:00444 N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine. 10356335 PubMed 51 UniMod N-acyl diglyceride cysteine UniMod-description ntermpeptripalmitatec OMSSA-label Tripalmitate PSI-MS-label DiffAvg 789.32 DiffFormula C 51 H 96 O 5 DiffMono 788.725776 Formula C 54 H 101 N 1 O 6 S 1 MassAvg 892.46 MassMono 891.734961 Origin C Source natural TermSpec N-term MOD:00899 has_functional_parent MOD:011440 PSI-MOD MOD:00445 L-homoarginine A protein modification that effectively converts an L-lysine residue to L-homoarginine, such as reaction with O-methylisourea. 11078590 PubMed 11085420 PubMed 11821862 PubMed 52 UniMod PSI-MOD-slim Guanidination UniMod-description guanidinationk OMSSA-label Guanidinyl PSI-MS-label DiffAvg 42.04 DiffFormula C 1 H 2 N 2 DiffMono 42.021798 Formula C 7 H 14 N 4 O 1 MassAvg 170.22 MassMono 170.116761 Origin K Source artifact TermSpec none MOD:00848 MOD:00912 PSI-MOD MOD:00446 4-hydroxynonenal adduct A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal. 11327326 PubMed 15133838 PubMed 53 UniMod 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. 4-hydroxynonenal (HNE) UniMod-description HNE PSI-MS-label DiffAvg 156.22 DiffFormula C 9 H 16 O 2 DiffMono 156.115030 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01155 PSI-MOD MOD:00447 N-glucuronylated residue A protein modification that effectively results from forming an adduct with a glucuronic acid either through a carboxyl group amide or ester bond, or through C1-glycosylation. 0 DeltaMass 7398618 PubMed 54#N-term UniMod PSI-MOD-slim Glucuronyl PSI-MS-label N-Glucuronyl (N terminus) DeltaMass-label N-glucuronylation UniMod-description DiffAvg 176.12 DiffFormula C 6 H 8 O 6 DiffMono 176.032088 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00764 PSI-MOD MOD:00448 N-acetylaminoglucosylated residue A protein modification that effectively replaces a hydrogen atom with an N-acetylaminoglucose group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim GlcNAcRes PSI-MOD-label HexNAc PSI-MS-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00733 MOD:01673 PSI-MOD MOD:00449 acetate labeling reagent (N-term) (heavy form, +3amu) modification from UniMod Isotopic label 11857757 PubMed 11999733 PubMed 12175151 PubMed 56 UniMod Acetate labeling reagent (N-term & K) (heavy form, +3amu) UniMod-description Acetyl:2H(3) PSI-MS-label DiffAvg 45.03 DiffFormula C 2 (1)H -1 (2)H 3 O 1 DiffMono 45.029395 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01431 PSI-MOD MOD:00450 acetate labeling reagent light form (K) OBSOLETE because this isotopic label from UniMod entry 57 is deprecated 11857757 PubMed DiffAvg 42.01 DiffFormula C 2 (1)H 2 O 1 DiffMono 42.010565 Formula none MassAvg none MassMono none Origin K Source artifact TermSpec none 1 PSI-MOD MOD:00451 alpha-amino propanoylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a propanoyl group. 11857757 PubMed 11999733 PubMed 12175151 PubMed 58#N-term UniMod Propionate labeling reagent light form (N-term & K) UniMod-description Propionyl PSI-MS-label DiffAvg 56.06 DiffFormula C 3 H 4 O 1 DiffMono 56.026215 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01894 PSI-MOD MOD:00452 alpha-amino 3x(13)C-labeled propanoylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(13)C-labeled propanoyl group. 11857757 PubMed 11999733 PubMed 12175151 PubMed 59#N-term UniMod Propionate labeling reagent heavy form (+3amu), N-term & K UniMod-description Propionyl:13C(3) PSI-MS-label DiffAvg 59.04 DiffFormula (13)C 3 H 4 O 1 DiffMono 59.036279 Formula (12)C 6 (13)C 3 H 16 N 2 O 2 MassAvg 187.13 MassMono 187.131242 Origin K Source artifact TermSpec none MOD:00451 PSI-MOD MOD:00453 quaternary amine labeling reagent light form (N-term & K) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent light form group. 11857757 PubMed 60 UniMod GIST-Quat PSI-MS-label Quaternary amine labeling reagent light form (N-term & K) UniMod-description DiffAvg 127.19 DiffFormula C 7 H 13 N 1 O 1 DiffMono 127.099714 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00454 quaternary amine labeling reagent heavy form (+3amu) (N-term & K) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+3amu) form group. 11857757 PubMed 61 UniMod GIST-Quat:2H(3) PSI-MS-label Quaternary amine labeling reagent heavy (+3amu) form, N-term & K UniMod-description DiffAvg 130.12 DiffFormula C 7 (1)H 10 (2)H 3 N 1 O 1 DiffMono 130.118544 Formula C 13 (1)H 22 (2)H 3 N 3 O 2 MassAvg 258.21 MassMono 258.213507 Origin X Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00455 quaternary amine labeling reagent heavy form (+6amu) (N-term & K) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+6amu) form group. 11857757 PubMed 62 UniMod GIST-Quat:2H(6) PSI-MS-label Quaternary amine labeling reagent heavy form (+6amu), N-term & K UniMod-description DiffAvg 133.14 DiffFormula C 7 H 7 (2)H 6 N 1 O 1 DiffMono 133.137375 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00456 quaternary amine labeling reagent heavy form (+9amu) (N-term & K) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+9amu) form group. 11857757 PubMed 63 UniMod GIST-Quat:2H(9) PSI-MS-label Quaternary amine labeling reagent heavy form (+9amu), N-term & K UniMod-description DiffAvg 136.16 DiffFormula C 7 (1)H 4 (2)H 9 N 1 O 1 DiffMono 136.156205 Formula C 13 (1)H 16 (2)H 9 N 3 O 2 MassAvg 264.25 MassMono 264.251168 Origin X Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00457 alpha-amino succinylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a succinyl group. 11857757 PubMed 12175151 PubMed 64#N-term UniMod Succinic anhydride labeling reagent light form (N-term) UniMod-description Succinyl PSI-MS-label DiffAvg 100.02 DiffFormula (12)C 4 (1)H 4 O 3 DiffMono 100.016044 Formula none MassAvg none MassMono none Origin X Source natural TermSpec N-term MOD:00848 MOD:01029 MOD:01696 PSI-MOD MOD:00458 4x(2)H labeled alpha-amino succinylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(2)H labeled succinyl group. 11857757 PubMed 12175151 PubMed 65#N-term UniMod Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term UniMod-description Succinyl:2H(4) PSI-MS-label DiffAvg 104.04 DiffFormula C 4 (2)H 4 O 3 DiffMono 104.041151 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00457 PSI-MOD MOD:00459 4x(13)C labeled alpha-amino succinylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(13)C labeled succinyl group. 11857757 PubMed 12175151 PubMed 66#N-term UniMod Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), N-term & K UniMod-description Succinyl:13C(4) PSI-MS-label DiffAvg 104.03 DiffFormula (13)C 4 H 4 O 3 DiffMono 104.029463 Formula none MassAvg none MassMono none Origin X TermSpec none MOD:00457 PSI-MOD MOD:00460 L-cysteic acid (L-cysteine sulfonic acid) A protein modification that effectively trioxygenates an L-cysteine residue to L-cysteine sulfonic acid. 17285 ChEBI 334 DeltaMass 14678012 PubMed 18306178 PubMed 19522542 PubMed 9252331 PubMed AA0556 RESID 345#C UniMod From DeltaMass: Notes:Treatment of cysteine by strongly oxidising reagents such as performic acid results in the complete oxidation of the sulphur atom. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. PSI-MOD-slim (2R)-2-amino-3-sulfopropanoic acid RESID-systematic 2-amino-2-carboxyethanesulfonic acid RESID-alternate 2-azanyl-3-sulfopropanoic acid RESID-alternate 3-sulfoalanine RESID-alternate Cya DeltaMass-label CysO3H PSI-MOD-label cysteic acid RESID-alternate Cysteic acid, oxidation of cysteine DeltaMass-label cysteicacidc OMSSA-label cysteine oxidation to cysteic acid UniMod-description cysteine sulphonic acid RESID-alternate L-cysteine sulfonic acid RESID-name Trioxidation PSI-MS-label DiffAvg 48.00 DiffFormula C 0 H 0 N 0 O 3 S 0 DiffMono 47.984744 Formula C 3 H 5 N 1 O 4 S 1 MassAvg 151.14 MassMono 150.993929 Origin C Source artifact TermSpec none MOD:00708 PSI-MOD MOD:00461 nitrosylation A protein modification that effectively substitutes a nitrite (NO2) group for a hydrogen atom. 0 DeltaMass 8839040 PubMed 9252331 PubMed 354 UniMod Note, this is often misrepresented as the introduction of a nitrate (NO3) group [JSG]. PSI-MOD-slim Nitro PSI-MS-label Nitro (NO2) DeltaMass-label Oxidation to nitro UniMod-description DiffAvg 45.00 DiffFormula H -1 N 1 O 2 DiffMono 44.985078 Formula none MassAvg none MassMono none Origin X TermSpec none MOD:00848 PSI-MOD MOD:00462 L-kynurenine A protein modification that effectively converts an L-tryptophan residue to L-kynurenine. 357 DeltaMass 11029593 PubMed 9252331 PubMed 351#W UniMod PSI-MOD-slim (2S)-2-amino-4-(2-aminophenyl)-4-oxo-butanoic acid PSI-MOD-alternate kynureninw OMSSA-label Trp->Kynurenin PSI-MS-label tryptophan oxidation to kynurenin UniMod-description DiffAvg 3.99 DiffFormula C -1 O 1 DiffMono 3.994915 Formula C 10 H 10 N 2 O 2 MassAvg 190.20 MassMono 190.074228 Origin W Source artifact TermSpec none MOD:00918 PSI-MOD MOD:00463 3'-hydroxy-L-kynurenine A protein modification that effectively converts an L-tryptophan residue to 3'-hydroxy-L-kynurenine. 9252331 PubMed 350#W UniMod PSI-MOD-slim hydroxykynureninw OMSSA-label Trp->Hydroxykynurenin PSI-MS-label tryptophan oxidation to hydroxykynurenin UniMod-description DiffAvg 19.99 DiffFormula C -1 O 2 DiffMono 19.989829 Formula C 10 H 10 N 2 O 3 MassAvg 206.20 MassMono 206.069142 Origin W Source artifact TermSpec none MOD:00679 MOD:00918 PSI-MOD MOD:00464 N'-formyl-L-kynurenine A protein modification that effectively converts an L-tryptophan residue to N'-formyl-L-kynurenine. 356 DeltaMass 12124932 PubMed 12686488 PubMed 9252331 PubMed 425#W UniMod From DeltaMass: References:Willy V. Bienvenut, Catherine Déon, Carla Pasquarello, Jennifer M. Campbell, Jean-Charles Sanchez, Marvin L. Vestal, Denis F. Hochstrasser Matrix-assisted laser desorption/ionization-tandemmass spectrometry with high resolution andsensitivity for identification and characterizationof proteins. Proteomics 2002, 2, 868-876 Notes: A double oxidation of tryptophan for which the N-formylkynurenine (+32) structure can be proposed. Many minor peaks accompanying the main peak might also be attributed to other oxidation products of the tryptophan such as kynurenine (+4), an unknown by-product found in all oxidized tryptophan patterns (+13), hydroxytryptophan (+16), 3-hydroxykynurenine (+20) and hydroxy-N-formylkynurenine (+48). See proposed structures at http://www.abrf.org/images/misc/dmass32.jpg. PSI-MOD-slim dihydroxy UniMod-description Dioxidation PSI-MS-label Double oxidation of Trp DeltaMass-label formylkynureninw OMSSA-label tryptophan oxidation to formylkynurenin UniMod-alternate DiffAvg 32.00 DiffFormula O 2 DiffMono 31.989829 Formula C 11 H 10 N 2 O 3 MassAvg 218.21 MassMono 218.069142 Origin W Source artifact TermSpec none MOD:00679 MOD:00918 PSI-MOD MOD:00465 dihydroxyphenylalanine (Phe) A protein modification that effectively converts an L-phenylalanine residue to a dihydroxyphenylalanine. 1610822 PubMed 1903612 PubMed 3734192 PubMed 9252331 PubMed AA0146#var RESID 425#F UniMod Dihydroxyphenyalanines with a 4'-hydroxyl orginate naturally by a monohydroxylation of tyrosine, and not by dihydroxylation of phenylalanine [JSG]. PSI-MOD-slim dihydroxy UniMod-description dihydroxyf OMSSA-label Dioxidation PSI-MS-label DiffAvg 32.00 DiffFormula O 2 DiffMono 31.989829 Formula C 9 H 9 N 1 O 3 MassAvg 179.17 MassMono 179.058243 Origin F Source artifact TermSpec none MOD:00428 MOD:00914 PSI-MOD MOD:00466 glycosylsphingolipidinositolated residue A protein modification that effectively converts a residue to a glycosylsphingolipidinositolethanolamidated. 12626404 PubMed 18688235 PubMed 8404891 PubMed GSIRes PSI-MOD-label MOD:00764 MOD:01155 PSI-MOD MOD:00467 iminobiotinyl modified residue A protein modification that effectively substitutes an iminobiotinyl group for a hydrogen atom. 9750125 PubMed 89 UniMod Iminobiotin PSI-MS-label Iminobiotinylation UniMod-description DiffAvg 225.31 DiffFormula C 10 H 15 N 3 O 1 S 1 DiffMono 225.093583 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00468 ESP-Tag light d0 modification from UniMod Isotopic label 90 UniMod ESP PSI-MS-label ESP-Tag light d0 UniMod-description DiffAvg 338.47 DiffFormula C 16 H 26 N 4 O 2 S 1 DiffMono 338.177647 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00469 ESP-Tag heavy d10 modification from UniMod Isotopic label 91 UniMod ESP-Tag heavy d10 UniMod-description ESP:2H(10) PSI-MS-label DiffAvg 348.24 DiffFormula C 16 (1)H 16 (2)H 10 N 4 O 2 S 1 DiffMono 348.240415 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01431 PSI-MOD MOD:00470 NHS-LC-Biotin modification from UniMod Chemical derivative 92 UniMod NHS-LC-Biotin UniMod-interim NHS-LC-Biotin UniMod-description DiffAvg 339.45 DiffFormula C 16 H 25 N 3 O 3 S 1 DiffMono 339.161663 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00471 EDT-maleimide-PEO-biotin modification from UniMod Chemical derivative 93 UniMod EDT-maleimide-PEO-biotin UniMod-interim EDT-maleimide-PEO-biotin UniMod-description DiffAvg 601.80 DiffFormula C 25 H 39 N 5 O 6 S 3 DiffMono 601.206247 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00472 IMID d0 modification from UniMod Isotopic label 11746907 PubMed 94 UniMod IMID PSI-MS-label IMID d0 UniMod-description DiffAvg 68.04 DiffFormula C 3 (1)H 4 N 2 DiffMono 68.037448 Formula C 9 H 16 N 4 O 1 MassAvg 196.13 MassMono 196.132411 Origin K Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00473 IMID d4 modification from UniMod Isotopic label 11746907 PubMed 95 UniMod IMID d4 UniMod-description IMID:2H(4) PSI-MS-label DiffAvg 72.06 DiffFormula C 3 (2)H 4 N 2 DiffMono 72.062555 Formula C 9 (1)H 12 (2)H 4 N 4 O 1 MassAvg 200.16 MassMono 200.157518 Origin K Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00474 S-([1,1,2-(2)H3]-carboxamidoethyl)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(1,1,2-(2)H3)-propanamide-L-cysteine. 97#C UniMod Acrylamide d3 UniMod-description Propionamide:2H(3) PSI-MS-label S-([1,1,2-(2)H3]-3-amino-3-oxopropyl)cysteine PSI-MOD-alternate S-([1,1,2-(2)H3]-carbamoylethyl)-L-cysteine PSI-MOD-alternate S-([1,1,2-(2)H3]-propanamide)-L-cysteine PSI-MOD-alternate DiffAvg 74.06 DiffFormula C 3 (1)H 2 (2)H 3 N 1 O 1 DiffMono 74.055944 Formula C 6 (1)H 7 (2)H 3 N 2 O 2 S 1 MassAvg 177.07 MassMono 177.065129 Origin C Source artifact TermSpec none MOD:00417 MOD:01426 PSI-MOD MOD:00475 tyrosine oxidation to 2-aminotyrosine modification from UniMod Chemical derivative 8839040 PubMed 9252331 PubMed 342#Y UniMod May be misdescribed. Name (if not misdescribed) should be 2'-aminotyrosine [JSG]. Amino PSI-MS-label Tyrosine oxidation to 2-aminotyrosine UniMod-description DiffAvg 15.02 DiffFormula H 1 N 1 DiffMono 15.010899 Formula C 9 H 10 N 2 O 2 MassAvg 178.19 MassMono 178.074228 Origin Y Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00476 galactosylated residue A protein modification that effectively replaces a hydrogen atom with an galactose group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim GalRes PSI-MOD-label MOD:00434 MOD:00728 PSI-MOD MOD:00477 2-pyrrolidone A protein modification that effectively converts, by oxidative decarboxylation, an L-proline residue to 2-pyrrolidone with breakage of the peptide chain. 2161657 PubMed 9252331 PubMed 360#P UniMod The oxidative decarboxylation of a proline residue results in breaking of the peptide chain, leaving a peptidyl-2-pyrrolidone at the C-terminus. The difference formula, derived from the result in the original citation, has been corrected from the UniMod entry. Pro->Pyrrolidinone PSI-MS-label Proline oxidation to pyrrolidinone UniMod-description DiffAvg -13.02 DiffFormula C -1 H -1 N 0 O 0 DiffMono -13.007825 Formula C 4 H 6 N 1 O 1 MassAvg 84.10 MassMono 84.044939 Origin P Source artifact TermSpec none MOD:00683 MOD:00915 MOD:00960 PSI-MOD MOD:00478 glutamyl semialdehyde (Pro) A protein modification that effectively converts an L-proline residue to L-glutamyl semialdehyde. 354 DeltaMass 11120890 PubMed 2563380 PubMed 9252331 PubMed 35#P UniMod gamma-glutamyl semialdehyde PSI-MOD-alternate glutamyl 5-semialdehyde PSI-MOD-alternate glutamyl aldehyde PSI-MOD-alternate Oxidation UniMod-interim Oxidation of proline to gamma-glutamyl semialdehyde DeltaMass-label Oxidation or Hydroxylation UniMod-description DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 7 N 1 O 2 MassAvg 113.12 MassMono 113.047678 Origin P Source artifact TermSpec none MOD:00679 MOD:00915 MOD:01440 PSI-MOD MOD:00479 glutamyl semialdehyde (Arg) A protein modification that effectively converts an L-arginine residue to L-glutamyl semialdehyde. 351 DeltaMass 11120890 PubMed 1680314 PubMed 9252331 PubMed 344#R UniMod From DeltaMass: Average Mass: -27 Monoisotopic Mass Change:-27.06 Average Mass Change:-27.07 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Arg->GluSA PSI-MS-label Arginine oxidation to glutamic semialdehyde UniMod-description Oxidation of arginine (to glutamic acid) DeltaMass-label DiffAvg -43.07 DiffFormula C -1 H -5 N -3 O 1 DiffMono -43.053433 Formula C 5 H 7 N 1 O 2 MassAvg 113.12 MassMono 113.047678 Origin R Source artifact TermSpec none MOD:00902 MOD:01440 PSI-MOD MOD:00480 Applied Biosystems cleavable ICAT(TM) light modification from UniMod Isotopic label 105#C UniMod PSI-MOD-slim Applied Biosystems cleavable ICAT(TM) light UniMod-description ICAT-C PSI-MS-label icatlight OMSSA-label DiffAvg 227.26 DiffFormula C 10 H 17 N 3 O 3 DiffMono 227.126991 Formula C 13 H 22 N 4 O 4 S 1 MassAvg 330.40 MassMono 330.136176 Origin C Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00481 Applied Biosystems cleavable ICAT(TM) heavy modification from UniMod Isotopic label 106#C UniMod PSI-MOD-slim Applied Biosystems cleavable ICAT(TM) heavy UniMod-description ICAT-C:13C(9) PSI-MS-label icatheavy OMSSA-label DiffAvg 236.16 DiffFormula (12)C 1 (13)C 9 H 17 N 3 O 3 DiffMono 236.157185 Formula (12)C 4 (13)C 9 H 22 N 4 O 4 S 1 MassAvg 339.17 MassMono 339.166370 Origin C Source artifact TermSpec none MOD:01428 PSI-MOD MOD:00482 N-formyl-L-methionine (Met) A protein modification that effectively converts an L-methionine residue to N-formyl-L-methionine (not known as a natural, post-translational modification process). 11152118 PubMed 2165784 PubMed 3042771 PubMed AA0021#MET RESID This entry is for the artifactual formation of N-formyl-L-methionine from methionine. For encoded N-formyl-L-methionine, use MOD:00030 [JSG]. (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid RESID-systematic 2-formamido-4-(methylsulfanyl)butanoic acid RESID-alternate 2-formylamino-4-(methylthio)butanoic acid RESID-alternate 2-formylazanyl-4-(methylsulfanyl)butanoic acid RESID-alternate MOD_RES N-formylmethionine UniProt-feature N-formyl-L-methionine RESID-name N-formylated L-methionine PSI-MOD-alternate NFoMet PSI-MOD-label DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 S 0 DiffMono 27.994915 Formula C 6 H 10 N 1 O 2 S 1 MassAvg 160.21 MassMono 160.043225 Origin M Source artifact TermSpec N-term MOD:00030 MOD:00913 PSI-MOD MOD:00483 N-ethylmaleimide derivatized cysteine A protein modification that is produced by reaction with N-ethylmaleimide. 11813307 PubMed 12777388 PubMed 108#C UniMod N-ethylmaleimide on cysteines UniMod-description nemc OMSSA-label Nethylmaleimide PSI-MS-label DiffAvg 125.13 DiffFormula C 6 H 7 N 1 O 2 DiffMono 125.047678 Formula C 9 H 12 N 2 O 3 S 1 MassAvg 228.27 MassMono 228.056863 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00484 oxidized lysine biotinylated with biotin-LC-hydrazide, reduced modification from UniMod Chemical derivative 112#K UniMod Oxidized lysine biotinylated with biotin-LC-hydrazide, reduced UniMod-description OxLysBiotinRed UniMod-interim DiffAvg 354.47 DiffFormula C 16 H 26 N 4 O 3 S 1 DiffMono 354.172562 Formula C 22 H 38 N 6 O 4 S 1 MassAvg 482.64 MassMono 482.267525 Origin K Source artifact TermSpec none MOD:00848 MOD:00912 PSI-MOD MOD:00485 oxidized lysine biotinylated with biotin-LC-hydrazide modification from UniMod Chemical derivative 113#K UniMod Oxidized lysine biotinylated with biotin-LC-hydrazide UniMod-description OxLysBiotin UniMod-interim DiffAvg 352.45 DiffFormula C 16 H 24 N 4 O 3 S 1 DiffMono 352.156912 Formula C 22 H 36 N 6 O 4 S 1 MassAvg 480.63 MassMono 480.251875 Origin K Source artifact TermSpec none MOD:00848 MOD:00912 PSI-MOD MOD:00486 oxidized proline biotinylated with biotin-LC-hydrazide, reduced modification from UniMod Chemical derivative 114#C UniMod Oxidized proline biotinylated with biotin-LC-hydrazide, reduced UniMod-description OxProBiotinRed UniMod-interim DiffAvg 371.50 DiffFormula C 16 H 29 N 5 O 3 S 1 DiffMono 371.199111 Formula C 21 H 36 N 6 O 4 S 1 MassAvg 468.62 MassMono 468.251875 Origin P Source artifact TermSpec none MOD:00848 MOD:00915 PSI-MOD MOD:00487 oxidized proline biotinylated with biotin-LC-hydrazide modification from UniMod Chemical derivative 115#C UniMod Oxidized Proline biotinylated with biotin-LC-hydrazide UniMod-description OxProBiotin UniMod-interim DiffAvg 369.48 DiffFormula C 16 H 27 N 5 O 3 S 1 DiffMono 369.183461 Formula C 21 H 34 N 6 O 4 S 1 MassAvg 466.60 MassMono 466.236225 Origin P Source artifact TermSpec none MOD:00848 MOD:00915 PSI-MOD MOD:00488 oxidized arginine biotinylated with biotin-LC-hydrazide modification from UniMod Chemical derivative 116#C UniMod OxArgBiotin UniMod-interim Oxidized arginine biotinylated with biotin-LC-hydrazide UniMod-description DiffAvg 310.41 DiffFormula C 15 H 22 N 2 O 3 S 1 DiffMono 310.135114 Formula C 21 H 34 N 6 O 4 S 1 MassAvg 466.60 MassMono 466.236225 Origin R Source artifact TermSpec none MOD:00848 MOD:00902 PSI-MOD MOD:00489 oxidized arginine biotinylated with biotin-LC-hydrazide, reduced modification from UniMod Chemical derivative 117#C UniMod OxArgBiotinRed UniMod-interim Oxidized arginine biotinylated with biotin-LC-hydrazide, reduced UniMod-description DiffAvg 312.43 DiffFormula C 15 H 24 N 2 O 3 S 1 DiffMono 312.150764 Formula C 21 H 36 N 6 O 4 S 1 MassAvg 468.62 MassMono 468.251875 Origin R Source artifact TermSpec none MOD:00848 MOD:00902 PSI-MOD MOD:00490 EDT-iodo-PEO-biotin modification from UniMod Chemical derivative 118 UniMod EDT-iodo-PEO-biotin UniMod-description EDT-iodoacetyl-PEO-biotin PSI-MS-label DiffAvg 490.70 DiffFormula C 20 H 34 N 4 O 4 S 3 DiffMono 490.174219 Formula none MassAvg none MassMono none Origin X TermSpec none MOD:00848 PSI-MOD MOD:00491 thio ether formation - BTP Adduct modification from UniMod Chemical derivative 11861642 PubMed 119#C UniMod IBTP PSI-MS-label Thio Ether Formation - BTP Adduct UniMod-description DiffAvg 316.38 DiffFormula C 22 H 21 P 1 DiffMono 316.138087 Formula C 25 H 26 N 1 O 1 P 1 S 1 MassAvg 419.52 MassMono 419.147272 Origin C Source artifact TermSpec none MOD:00848 MOD:00861 MOD:00905 PSI-MOD MOD:00492 ubiquitination signature dipeptidyl lysine A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of glycylglycine, the two glycine residues left after tryptic digestion of ubiquitin. 11125103 PubMed 12612601 PubMed 12872131 PubMed AA0125#var RESID 121#K UniMod GlyGly PSI-MS-label glyglyk OMSSA-label N6-(glycylglycyl)lysine PSI-MOD-alternate N6-glycylglycyl-L-lysine PSI-MOD-alternate ubiquitinylation residue UniMod-description DiffAvg 114.10 DiffFormula C 4 H 6 N 2 O 2 DiffMono 114.042927 Formula C 10 H 18 N 4 O 3 MassAvg 242.28 MassMono 242.137890 Origin K Source artifact TermSpec none MOD:00908 MOD:01875 derives_from MOD:011480 PSI-MOD MOD:00493 formylated residue A protein modification that effectively replaces a hydrogen atom with a formyl group. 0 DeltaMass 15799070 PubMed 122 UniMod From DeltaMass: Average Mass: 28 PSI-MOD-slim FoRes PSI-MOD-label Formyl PSI-MS-label Formylation UniMod-description Formylation (CHO) DeltaMass-label DiffAvg 28.01 DiffFormula C 1 O 1 DiffMono 27.994915 Formula none MassAvg none MassMono none Origin X TermSpec none MOD:00649 PSI-MOD MOD:00494 N-iodoacetyl, p-chlorobenzyl-12C6-glucamine modification from UniMod Isotopic label 12185208 PubMed 123#C UniMod ICAT-H PSI-MS-label N-iodoacetyl, p-chlorobenzyl-12C6-glucamine UniMod-description DiffAvg 345.78 DiffFormula C 15 Cl 1 H 20 N 1 O 6 S 0 DiffMono 345.097915 Formula C 18 Cl 1 H 25 N 2 O 7 S 1 MassAvg 448.91 MassMono 448.107100 Origin C Source artifact TermSpec none MOD:00905 MOD:01426 PSI-MOD MOD:00495 N-iodoacetyl, p-chlorobenzyl-13C6-glucamine modification from UniMod Isotopic label 12185208 PubMed 124#C UniMod ICAT-H:13C(6) PSI-MS-label N-iodoacetyl, p-chlorobenzyl-13C6-glucamine UniMod-description DiffAvg 351.12 DiffFormula (12)C 9 (13)C 6 Cl 1 H 20 N 1 O 6 S 0 DiffMono 351.118044 Formula (12)C 12 (13)C 6 Cl 1 H 25 N 2 O 7 S 1 MassAvg 454.13 MassMono 454.127229 Origin C Source artifact TermSpec none MOD:00905 MOD:01426 PSI-MOD MOD:00496 reductive amination-D OBSOLETE because UniMod entry 125 is merged with entry 199, remap to id: MOD:00552 125 UniMod DiffAvg 32.06 DiffFormula C 2 (2)H 4 DiffMono 32.056407 Formula none MassAvg none MassMono none Origin K Source artifact TermSpec none 1 PSI-MOD MOD:00497 3-sulfanylpropanoyl (N-term and Lys) modification from UniMod [(35)S]dithiobis(succinimidyl propionate) crosslinking 957432 PubMed 126 UniMod The name "thioacylation of primary amines" in UniMod was a misdescription [JSG]. 3,3-Dithio-bis-(sulfosuccinimidyl)propionate UniMod-alternate 3-sulfanylpropanoyl UniMod-description Thioacyl PSI-MS-label DiffAvg 88.12 DiffFormula C 3 H 4 O 1 S 1 DiffMono 87.998286 Formula C 9 H 16 N 2 O 2 S 1 MassAvg 216.30 MassMono 216.093249 Origin K Source artifact TermSpec none MOD:00848 MOD:00912 PSI-MOD MOD:00498 fluorinated residue A protein modification that effectively substitutes a hydrogen of a residue with a fluorine atom. 18688235 PubMed Fluoro PSI-MS-label fluorophenylalanine replacement of phenylalanine UniMod-description Fluorophenylalanyl DeltaMass-label FRes PSI-MOD-label Origin X Source artifact TermSpec none MOD:00694 PSI-MOD MOD:00499 5-iodoacetamidofluorescein modification from UniMod Chemical derivative 3311742 PubMed 3578767 PubMed 128#C UniMod 5-Iodoacetamidofluorescein (Molecular Probe, Eugene, OR) UniMod-description Fluorescein PSI-MS-label DiffAvg 388.35 DiffFormula C 22 H 14 N 1 O 6 DiffMono 388.082112 Formula C 25 H 19 N 2 O 7 S 1 MassAvg 491.49 MassMono 491.091297 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00500 monoiodinated residue A protein modification that effectively substitutes one hydrogen atom of a residue with one iodine atom. 0 DeltaMass 15627961 PubMed 2026710 PubMed 129 UniMod From DeltaMass: Average Mass: 126 PSI-MOD-slim I1Res PSI-MOD-label Iodination UniMod-description Iodination (of Histidine[C4] or Tyrosine[C3]) DeltaMass-label Iodo PSI-MS-label DiffAvg 125.90 DiffFormula H -1 I 1 DiffMono 125.896648 Formula none MassAvg none MassMono none Origin X TermSpec none MOD:00755 PSI-MOD MOD:00501 diiodinated residue A protein modification that effectively substitutes two hydrogen atoms of a residue with two iodine atoms. 130 UniMod From DeltaMass: Average Mass: 252 PSI-MOD-slim di-Iodination UniMod-description Diiodo PSI-MS-label I2Res PSI-MOD-label DiffAvg 251.79 DiffFormula H -2 I 2 DiffMono 251.793295 Formula none MassAvg none MassMono none Origin X TermSpec none MOD:00755 PSI-MOD MOD:00502 triiodinated residue A protein modification that effectively substitutes three hydrogen atoms of a residue with three iodine atoms. 15627961 PubMed 2026710 PubMed 131 UniMod From UniMod. In PubMed:2026710, mono- and diiodination of tyrosine are discussed, but triiodination of tyrosine is not mentioned. In PubMed:15627961, triiodothyronine (see MOD:00186) is discussed, but triiodotyrosine is not mentioned. This modification probably does not exist, and may be a confusion of "tyrosine" for "thyronine", a common error [JSG]. PSI-MOD-slim I3Res PSI-MOD-label tri-Iodination UniMod-description triiodinationy OMSSA-label Triiodo PSI-MS-label DiffAvg 377.69 DiffFormula H -3 I 3 DiffMono 377.689943 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00755 PSI-MOD MOD:00503 N-(cis-delta 5)-tetradecaenoylglycine A protein modification that effectively converts a glycine residue to N-(cis-delta 5)-tetradecaenoylglycine. 11955007 PubMed 11955008 PubMed 1326520 PubMed 1386601 PubMed 6436247 PubMed 7543369 PubMed AA0059#var RESID 134#G UniMod (cis-delta 5)-tetradecaenoyl UniMod-description Myristoleyl PSI-MS-label myristoleylation (one double bond) DeltaMass-label N-(C14:1 aliphatic acyl)glycine PSI-MOD-alternate ntermpepmyristoyeylationg OMSSA-label DiffAvg 208.35 DiffFormula C 14 H 24 N 0 O 1 DiffMono 208.182715 Formula C 16 H 27 N 1 O 2 MassAvg 265.40 MassMono 265.204179 Origin G Source natural TermSpec N-term MOD:00908 MOD:01696 PSI-MOD MOD:00504 N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine A protein modification that effectively converts a glycine residue to N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine. 11955007 PubMed 11955008 PubMed 1326520 PubMed 1386601 PubMed 6436247 PubMed 7543369 PubMed AA0059#var RESID 135#G UniMod (cis,cis-delta 5, delta 8)-tetradecadienoyl UniMod-description Myristoyl+Delta:H(-4) PSI-MS-label myristoylation-4H (two double bonds) DeltaMass-label N-(C14:2 aliphatic acyl)glycine PSI-MOD-alternate ntermpepmyristoyl4hg OMSSA-label DiffAvg 206.33 DiffFormula C 14 H 22 O 1 DiffMono 206.167065 Formula C 16 H 25 N 1 O 2 MassAvg 263.38 MassMono 263.188529 Origin G Source natural TermSpec N-term MOD:00908 MOD:01696 PSI-MOD MOD:00505 benzoyl labeling reagent light form (N-term and K) modification from UniMod Isotopic label 0 DeltaMass 15456300 PubMed 136 UniMod From DeltaMass: Average Mass: 104 Benzoyl PSI-MS-label Benzoyl (Bz) DeltaMass-label labeling reagent light form (N-term & K) UniMod-description DiffAvg 104.11 DiffFormula C 7 H 4 O 1 DiffMono 104.026215 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00506 N-linked glycan core modification from UniMod N-linked glycosylation, Hex(5) HexNAc(2) 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID 137#N UniMod Hex(5)HexNAc(2) PSI-MS-label N-linked glycan core UniMod-description DiffAvg 1217.09 DiffFormula C 46 H 76 N 2 O 35 DiffMono 1216.422862 Formula C 50 H 82 N 4 O 37 MassAvg 1331.20 MassMono 1330.465790 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00507 5-dimethylaminonaphthalene-1-sulfonyl OBSOLETE because redundant, replaced by MOD:01653. Remap to MOD:01653. 0 DeltaMass 139 UniMod From DeltaMass: Average Mass: 233 5-dimethylaminonaphthalene-1-sulfonyl UniMod-description Dansyl PSI-MS-label Dansyl (Dns) DeltaMass-label DiffAvg 233.29 DiffFormula C 12 H 11 N 1 O 2 S 1 DiffMono 233.051050 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none 1 PSI-MOD MOD:00508 ISD a-series (C-Term) modification from UniMod Other 14588022 PubMed 140 UniMod Virtual Modification for MS/MS of a-type ions, by decarboxylation of C-terminus as reaction inside the mass spectrometer. a-type-ion PSI-MS-label ISD a-series (C-Term) UniMod-description DiffAvg -29.02 DiffFormula C -1 H -1 O -1 DiffMono -29.002740 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec C-term MOD:00003 PSI-MOD MOD:00509 amidination of lysines or N-terminal amines with methyl acetimidate modification from UniMod Chemical derivative 12643539 PubMed 6273432 PubMed 141 UniMod amidination of lysines or N-terminal amines with methyl acetimidate UniMod-description Amidine PSI-MS-label DiffAvg 41.05 DiffFormula C 2 H 3 N 1 DiffMono 41.026549 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00510 HexNAc1dHex1 modification from UniMod N-linked glycosylation, dHex HexNAc 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID 142 UniMod dHexHexNAcN OMSSA-label HexNAc(1)dHex(1) PSI-MS-label HexNAc1dHex1 UniMod-description DiffAvg 349.34 DiffFormula C 14 H 23 N 1 O 9 DiffMono 349.137281 Formula C 18 H 29 N 3 O 11 MassAvg 463.44 MassMono 463.180209 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00511 HexNAc2 modification from UniMod N-linked glycosylation, HexNAc(2) 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID 143 UniMod HexNAc(2) PSI-MS-label HexNAc2 UniMod-description DiffAvg 406.39 DiffFormula C 16 H 26 N 2 O 10 DiffMono 406.158745 Formula C 20 H 32 N 4 O 12 MassAvg 520.49 MassMono 520.201672 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00512 Hex3 modification from UniMod N-linked glycosylation, Hex3 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID 144 UniMod Hex(3) PSI-MS-label Hex3 UniMod-description DiffAvg 486.42 DiffFormula C 18 H 30 O 15 DiffMono 486.158470 Formula C 22 H 36 N 2 O 17 MassAvg 600.53 MassMono 600.201398 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00513 HexNAc1dHex2 modification from UniMod N-linked glycosylation, dHex(2) HexNAc 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID 145 UniMod HexNAc(1)dHex(2) PSI-MS-label HexNAc1dHex2 UniMod-description DiffAvg 495.48 DiffFormula C 20 H 33 N 1 O 13 DiffMono 495.195190 Formula C 24 H 39 N 3 O 15 MassAvg 609.58 MassMono 609.238118 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00514 Hex1HexNAc1dHex1 modification from UniMod N-linked glycosylation, dHex Hex HexNAc 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID 146 UniMod Hex(1)HexNAc(1)dHex(1) PSI-MS-label Hex1HexNAc1dHex1 UniMod-description DiffAvg 511.48 DiffFormula C 20 H 33 N 1 O 14 DiffMono 511.190105 Formula C 24 H 39 N 3 O 16 MassAvg 625.58 MassMono 625.233032 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00515 HexNAc2dHex1 modification from UniMod N-linked glycosylation, dHex HexNAc(2) 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID 147 UniMod HexNAc(2)dHex(1) PSI-MS-label HexNAc2dHex1 UniMod-description DiffAvg 552.53 DiffFormula C 22 H 36 N 2 O 14 DiffMono 552.216654 Formula C 26 H 42 N 4 O 16 MassAvg 666.63 MassMono 666.259581 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00516 Hex1HexNAc2 modification from UniMod N-linked glycosylation AA0151#var RESID 148 UniMod Hex(1)HexNAc(2) PSI-MS-label Hex1HexNAc2 UniMod-description DiffAvg 568.53 DiffFormula C 22 H 36 N 2 O 15 DiffMono 568.211568 Formula C 26 H 42 N 4 O 17 MassAvg 682.63 MassMono 682.254496 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00517 Hex1HexNAc1NeuAc1 glycosylated residue A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. 0 DeltaMass 149 UniMod From DeltaMass: Average Mass: 657 Hex(1)HexNAc(1)NeuAc(1) PSI-MS-label Hex1HexNAc1NeuAc1 UniMod-description NeuAc-Hex-HexNAc DeltaMass-label DiffAvg 657.60 DiffFormula C 25 H 41 N 2 O 18 DiffMono 657.235437 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00725 PSI-MOD MOD:00518 HexNAc2dHex2 modification from UniMod N-linked glycosylation AA0151#var RESID 150 UniMod HexNAc(2)dHex(2) PSI-MS-label HexNAc2dHex2 UniMod-description DiffAvg 698.67 DiffFormula C 28 H 46 N 2 O 18 DiffMono 698.274563 Formula C 32 H 52 N 4 O 20 MassAvg 812.78 MassMono 812.317490 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00519 Hex1HexNAc2Pent1 modification from UniMod N-linked glycosylation AA0151#var RESID 151 UniMod Hex(1)HexNAc(2)Pent(1) PSI-MS-label Hex1HexNAc2Pent1 UniMod-description DiffAvg 700.64 DiffFormula C 27 H 44 N 2 O 19 DiffMono 700.253827 Formula C 31 H 50 N 4 O 21 MassAvg 814.75 MassMono 814.296755 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00520 Hex1HexNAc2dHex1 modification from UniMod N-linked glycosylation AA0151#var RESID 152 UniMod Hex(1)HexNAc(2)dHex(1) PSI-MS-label Hex1HexNAc2dHex1 UniMod-description DiffAvg 714.67 DiffFormula C 28 H 46 N 2 O 19 DiffMono 714.269477 Formula C 32 H 52 N 4 O 21 MassAvg 828.77 MassMono 828.312405 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00521 Hex2HexNAc2 modification from UniMod N-linked glycosylation AA0151#var RESID 153 UniMod Hex(2)HexNAc(2) PSI-MS-label Hex2HexNAc2 UniMod-description DiffAvg 730.67 DiffFormula C 28 H 46 N 2 O 20 DiffMono 730.264392 Formula C 32 H 52 N 4 O 22 MassAvg 844.77 MassMono 844.307319 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00522 Hex3HexNAc1Pent1 modification from UniMod N-linked glycosylation AA0151#var RESID 154 UniMod Hex(3)HexNAc(1)Pent(1) PSI-MS-label Hex3HexNAc1Pent1 UniMod-description DiffAvg 821.73 DiffFormula C 31 H 51 N 1 O 24 DiffMono 821.280102 Formula C 35 H 57 N 3 O 26 MassAvg 935.84 MassMono 935.323029 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00523 Hex1HexNAc2dHex1Pent1 modification from UniMod N-linked glycosylation AA0151#var RESID 155 UniMod Hex(1)HexNAc(2)dHex(1)Pent(1) PSI-MS-label Hex1HexNAc2dHex1Pent1 UniMod-description DiffAvg 846.79 DiffFormula C 33 H 54 N 2 O 23 DiffMono 846.311736 Formula C 35 H 57 N 3 O 26 MassAvg 935.84 MassMono 935.323029 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00524 Hex1HexNAc2dHex2 modification from UniMod N-linked glycosylation AA0151#var RESID 156 UniMod Hex(1)HexNAc(2)dHex(2) PSI-MS-label Hex1HexNAc2dHex2 UniMod-description DiffAvg 860.81 DiffFormula C 34 H 56 N 2 O 23 DiffMono 860.327386 Formula C 38 H 62 N 4 O 25 MassAvg 974.92 MassMono 974.370313 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00525 Hex2HexNAc2Pent1 modification from UniMod N-linked glycosylation AA0151#var RESID 157 UniMod Hex(2)HexNAc(2)Pent(1) PSI-MS-label Hex2HexNAc2Pent1 UniMod-description DiffAvg 862.79 DiffFormula C 33 H 54 N 2 O 24 DiffMono 862.306651 Formula C 37 H 60 N 4 O 26 MassAvg 976.89 MassMono 976.349578 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00526 Hex2HexNAc2dHex1 modification from UniMod N-linked glycosylation AA0151#var RESID 158 UniMod Hex(2)HexNAc(2)dHex(1) PSI-MS-label Hex2HexNAc2dHex1 UniMod-description DiffAvg 876.81 DiffFormula C 34 H 56 N 2 O 24 DiffMono 876.322301 Formula C 38 H 62 N 4 O 26 MassAvg 990.92 MassMono 990.365228 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00527 Hex3HexNAc2 modification from UniMod N-linked glycosylation 0 DeltaMass AA0151#var RESID 159 UniMod From DeltaMass: Average Mass: 893 (Hex)3-HexNAc-HexNAc DeltaMass-label Hex(3)HexNAc(2) PSI-MS-label Hex3HexNAc2 UniMod-description DiffAvg 892.81 DiffFormula C 34 H 56 N 2 O 25 DiffMono 892.317215 Formula C 38 H 62 N 4 O 27 MassAvg 1006.92 MassMono 1006.360143 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00528 Hex1HexNAc1NeuAc2 glycosylated residue A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. 160 UniMod Hex(1)HexNAc(1)NeuAc(2) PSI-MS-label Hex1HexNAc1NeuAc2 UniMod-description DiffAvg 947.85 DiffFormula C 36 H 57 N 3 O 26 DiffMono 947.323029 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00725 PSI-MOD MOD:00529 Hex3HexNAc2P1 modification from UniMod N-linked glycosylation AA0151#var RESID 161 UniMod Hex(3)HexNAc(2)P(1) PSI-MS-label Hex3HexNAc2P1 UniMod-description DiffAvg 972.79 DiffFormula C 34 H 57 N 2 O 28 P 1 DiffMono 972.283546 Formula C 38 H 63 N 4 O 30 P 1 MassAvg 1086.89 MassMono 1086.326473 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:00530 L-selenomethionine A protein modification that effectively converts an L-methionine residue to L-selenomethionine. 12148805 PubMed 162#M UniMod Delta:S(-1)Se(1) PSI-MS-label Se(S)Met PSI-MOD-label Selenium replaces sulphur UniMod-description semetm OMSSA-label DiffAvg 46.91 DiffFormula C 0 H 0 N 0 S -1 Se 1 DiffMono 47.944450 Formula C 5 H 9 N 1 O 1 Se 1 MassAvg 178.10 MassMono 178.984935 Origin M Source artifact TermSpec none MOD:00007 MOD:00913 PSI-MOD MOD:00531 (18)O labeled deglycosylated asparagine A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O as the result of having been deglycosylated in (18)O water. 14435542 PubMed 170 UniMod PSI-MOD-slim Delta:H(1)O(-1)18O(1) PSI-MS-label glycosylated asparagine 18O labeling UniMod-description DiffAvg 2.99 DiffFormula H -1 N -1 (18)O 1 DiffMono 2.988262 Formula C 4 H 5 N 1 (16)O 2 (18)O 1 MassAvg 117.03 MassMono 117.031189 Origin N Source artifact TermSpec none MOD:01293 PSI-MOD MOD:00532 Shimadzu 13CNBS modification from UniMod Chemical derivative 12845591 PubMed 171 UniMod NBS:13C(6) UniMod-interim Shimadzu NBS-13C UniMod-description DiffAvg 159.01 DiffFormula (13)C 6 H 3 N 1 O 2 S 1 DiffMono 159.008578 Formula (12)C 11 (13)C 6 H 13 N 3 O 3 S 1 MassAvg 345.09 MassMono 345.087891 Origin W Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00533 Shimadzu 12CNBS modification from UniMod Chemical derivative 12845591 PubMed 172 UniMod NBS UniMod-interim Shimadzu NBS-12C UniMod-description DiffAvg 152.99 DiffFormula (12)C 6 H 3 N 1 O 2 S 1 DiffMono 152.988449 Formula (12)C 17 H 13 N 3 O 3 S 1 MassAvg 339.07 MassMono 339.067762 Origin W Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00534 Michael addition of BHT quinone methide to cysteine and lysine modification from UniMod Post-translational 9448752 PubMed 176 UniMod Butylated Hydroxytoluene adduct. BHT PSI-MS-label Michael addition of BHT quinone methide to Cysteine and Lysine UniMod-description DiffAvg 218.34 DiffFormula C 15 H 22 O 1 DiffMono 218.167065 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00535 phosphorylation to amine thiol modification from UniMod Chemical derivative 12216740 PubMed 178 UniMod DAET = 2-(dimethylamino)ethanethiol. The phosphorylation to amine is the beta elimination of phosphate and Michael addition of 2-(dimethylamino)ethanethiol to the site. DAET PSI-MS-label phosphorylation to amine thiol UniMod-description DiffAvg 87.18 DiffFormula C 4 H 9 N 1 O -1 S 1 DiffMono 87.050656 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00536 L-serine to L-alanine replacement OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? a protein modification that replaces an L-serine residue with an L-alanine residue 179 UniMod Ser_Ala PSI-MOD-label DiffAvg -16.00 DiffFormula O -1 DiffMono -15.994915 Formula none MassAvg none MassMono none Origin S Source artifact TermSpec none 1 PSI-MOD MOD:00537 L-alanine residue (Thr) A protein modification that effectively converts an L-threonine residue to L-alanine. 659 UniMod This could represent either an engineered replacement or a chemical modification. Thr(Ala) PSI-MOD-label Thr->Ala UniMod-interim Thr->Ala substitution UniMod-description DiffAvg -30.03 DiffFormula C -1 H -2 O -1 DiffMono -30.010565 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin T Source none TermSpec none MOD:00010 MOD:00917 PSI-MOD MOD:00538 protein modification categorized by isobaric sets Modified amino acid residues groups into isobaric sets at particular mass resolution cut-offs. 18688235 PubMed PSI-MOD-slim MOD:00000 PSI-MOD MOD:00539 threonine reduced to aminobutynate OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? modification from UniMod O-linked glycosylation 182 UniMod DiffAvg -17.01 DiffFormula H -1 O -1 DiffMono -17.002740 Formula none MassAvg none MassMono none Origin T Source artifact TermSpec none 1 PSI-MOD MOD:00540 9x(13)C labeled residue A protein modification that effectively converts a residue containing common isotopes to a 9x(13)C labeled residue. 12716131 PubMed 184 UniMod 13C(9) Silac label UniMod-description Label:13C(9) PSI-MS-label DiffAvg 9.03 DiffFormula (12)C -9 (13)C 9 DiffMono 9.030194 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00842 PSI-MOD MOD:00541 9x(13)C labeled L-phosphotyrosine A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-phosphotyrosine. 12716131 PubMed 185 UniMod C13 label (Phosphotyrosine) UniMod-description Label:13C(9)+Phospho PSI-MS-label DiffAvg 89.00 DiffFormula (12)C -9 (13)C 9 H 1 O 3 P 1 DiffMono 88.996524 Formula (13)C 9 H 10 N 1 O 5 P 1 MassAvg 252.06 MassMono 252.059853 Origin Y Source artifact TermSpec none MOD:00540 MOD:00919 derives_from MOD:000480 PSI-MOD MOD:00542 hydroxyphenylglyoxal arginine modification from UniMod Chemical derivative 11698400 PubMed 11914093 PubMed 186 UniMod HPG PSI-MS-label Hydroxyphenylglyoxal arginine UniMod-description DiffAvg 132.12 DiffFormula C 8 H 4 O 2 DiffMono 132.021129 Formula C 14 H 16 N 4 O 3 MassAvg 288.31 MassMono 288.122240 Origin R Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00543 bis(hydroxyphenylglyoxal) arginine modification from UniMod Chemical derivative 11698400 PubMed 187 UniMod OH-PGO and PGO react with arginine at a stoichiometry of 2:1 [UniMod]. 2HPG PSI-MS-label bis(hydroxphenylglyoxal) arginine UniMod-description DiffAvg 282.25 DiffFormula C 16 H 10 O 5 DiffMono 282.052823 Formula C 22 H 22 N 4 O 6 MassAvg 438.44 MassMono 438.153934 Origin R Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00544 6x(13)C labeled residue A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C labeled residue. 12716131 PubMed 188 UniMod PSI-MOD-slim 13C(6) Silac label UniMod-description Label:13C(6) PSI-MS-label DiffAvg 6.02 DiffFormula (12)C -6 (13)C 6 DiffMono 6.020129 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00842 PSI-MOD MOD:00545 deuterated dimethyl labeling (D) OBSOLETE because redundant with MOD:00927. Remap to MOD:00927. 14670044 PubMed DiffAvg 34.07 DiffFormula C 2 (1)H -2 (2)H 6 DiffMono 34.068961 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term 1 PSI-MOD MOD:00546 (18)O label at both C-terminal oxygens A protein modification that effectively substitutes two (18)O atom for the two (16)O atoms of an alpha-carboxyl (1-carboxyl) group. 11467524 PubMed 193 UniMod PSI-MOD-slim ctermpepdio18 OMSSA-label Label:18O(2) PSI-MS-label O18 label at both C-terminal oxygens UniMod-description DiffAvg 4.01 DiffFormula (16)O -2 (18)O 2 DiffMono 4.008493 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec C-term MOD:00847 PSI-MOD MOD:00547 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate modification from UniMod Chemical derivative 14997490 PubMed 194 UniMod 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate UniMod-description AccQTag PSI-MS-label DiffAvg 170.17 DiffFormula C 10 H 6 N 2 O 1 DiffMono 170.048013 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00548 APTA-d0 modification from UniMod Chemical derivative 15283597 PubMed 195 UniMod Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride [JSG]. APTA-d0 UniMod-description QAT PSI-MS-label DiffAvg 171.26 DiffFormula C 9 H 19 N 2 O 1 DiffMono 171.149738 Formula C 12 H 24 N 3 O 2 S 1 MassAvg 274.40 MassMono 274.158923 Origin C Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00549 APTA d3 modification from UniMod Isotopic label 15283597 PubMed 196 UniMod Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride (difference formula correct) [JSG]. (3-acrylamidopropyl)trimethylammonium UniMod-description APTA d3 UniMod-description QAT:2H(3) PSI-MS-label DiffAvg 174.17 DiffFormula C 9 (1)H 16 (2)H 3 N 2 O 1 DiffMono 174.168568 Formula C 12 (1)H 21 (2)H 3 N 3 O 2 S 1 MassAvg 277.18 MassMono 277.177753 Origin C Source artifact TermSpec none MOD:01431 PSI-MOD MOD:00550 EAPTA d0 modification from UniMod Chemical derivative 197 UniMod EAPTA d0 UniMod-description EQAT PSI-MS-label DiffAvg 184.28 DiffFormula C 10 H 20 N 2 O 1 DiffMono 184.157563 Formula C 13 H 25 N 3 O 2 S 1 MassAvg 287.42 MassMono 287.166748 Origin C Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00551 EAPTA d5 modification from UniMod Isotopic label 198 UniMod EAPTA d5 UniMod-description EQAT:2H(5) PSI-MS-label DiffAvg 189.19 DiffFormula C 10 (1)H 15 (2)H 5 N 2 O 1 DiffMono 189.188947 Formula C 13 (1)H 20 (2)H 5 N 3 O 2 S 1 MassAvg 292.20 MassMono 292.198132 Origin C Source artifact TermSpec none MOD:01431 PSI-MOD MOD:00552 4x(2)H labeled dimethylated residue A protein modification that effectively converts a residue containing common isotopes to a 4x(2)H labeled dimethylated residue. 14670044 PubMed 199 UniMod Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. PSI-MOD-slim DiMethyl-CHD2 UniMod-description Dimethyl:2H(4) PSI-MS-label DiffAvg 32.06 DiffFormula C 2 (2)H 4 DiffMono 32.056407 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00839 PSI-MOD MOD:00553 1,2-ethanedithiol modified residue A protein modification that effectively substitutes a (2-sulfanylethyl)sulfanyl (or thioethylthiol) group for a hydroxy group. 0 DeltaMass 11507762 PubMed 200 UniMod From DeltaMass: Average Mass: 93; supposed to be derivatization of serine and threonine. 1,2-ethanedithiol (EDT) DeltaMass-label EDT UniMod-description Ethanedithiol PSI-MS-label DiffAvg 76.18 DiffFormula C 2 H 4 O -1 S 2 DiffMono 75.980528 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00554 APTA-d0 with no neutral loss OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative 202 UniMod DiffAvg 170.26 DiffFormula C 9 H 18 N 2 O 1 DiffMono 170.141913 Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none 1 PSI-MOD MOD:00555 APTA-d0 with quaternary amine loss OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative 203 UniMod DiffAvg 170.26 DiffFormula C 9 H 18 N 2 O 1 DiffMono 170.141913 Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none 1 PSI-MOD MOD:00556 acrolein addition +94 modification from UniMod Other 205 UniMod Acrolein addition +94 UniMod-description Delta:H(6)C(6)O(1) PSI-MS-label DiffAvg 94.11 DiffFormula C 6 H 6 O 1 DiffMono 94.041865 Formula C 12 H 18 N 2 O 2 MassAvg 222.29 MassMono 222.136828 Origin K Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00557 acrolein addition +56 modification from UniMod Other 10825247 PubMed 15541752 PubMed 206 UniMod Acrolein addition +56 UniMod-description Delta:H(4)C(3)O(1) PSI-MS-label DiffAvg 56.06 DiffFormula C 3 H 4 O 1 DiffMono 56.026215 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00558 acrolein addition +38 modification from UniMod Other 207 UniMod Acrolein addition +38 UniMod-description Delta:H(2)C(3) PSI-MS-label DiffAvg 38.05 DiffFormula C 3 H 2 DiffMono 38.015650 Formula C 9 H 14 N 2 O 1 MassAvg 166.22 MassMono 166.110613 Origin K Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00559 acrolein addition +76 modification from UniMod Other 208 UniMod Acrolein addition +76 UniMod-description Delta:H(4)C(6) PSI-MS-label DiffAvg 76.10 DiffFormula C 6 H 4 DiffMono 76.031300 Formula C 12 H 16 N 2 O 1 MassAvg 204.27 MassMono 204.126263 Origin K Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00560 acrolein addition +112 modification from UniMod Other 209 UniMod Acrolein addition +112 UniMod-description Delta:H(8)C(6)O(2) PSI-MS-label DiffAvg 112.13 DiffFormula C 6 H 8 O 2 DiffMono 112.052429 Formula C 12 H 20 N 2 O 3 MassAvg 240.30 MassMono 240.147393 Origin K Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00561 N-ethyl iodoacetamide-d0 modification from UniMod Isotopic label 12766232 PubMed 211 UniMod N-ethyl iodoacetamide-d0 UniMod-description NEIAA PSI-MS-label DiffAvg 85.11 DiffFormula C 4 H 7 N 1 O 1 DiffMono 85.052764 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00562 N-ethyl iodoacetamide-d5 modification from UniMod Isotopic label 12766232 PubMed 212 UniMod N-ethyl iodoacetamide-d5 UniMod-description NEIAA:2H(5) PSI-MS-label DiffAvg 90.08 DiffFormula C 4 (1)H 2 (2)H 5 N 1 O 1 DiffMono 90.084148 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01431 PSI-MOD MOD:00563 N-acetylaminogalactosylated residue A protein modification that effectively replaces a hydrogen atom with an N-acetylaminogalactose group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim GalNAcRes PSI-MOD-label HexNAc PSI-MS-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00734 MOD:01673 PSI-MOD MOD:00564 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Modification from UniMod Isotopic label. The UniMod term was extracted when it had not been approved. OBSOLETE because redundant to MOD:01505. Remap to MOD:01505, or one of the child terms MOD:01493 or MOD:01497. 214 UniMod iTRAQ4plex UniMod-interim Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 O 1 DiffMono 144.102062 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none 1 PSI-MOD MOD:00565 deglycosylated asparagine modification from UniMod N-linked glycosylation 7#N UniMod Conversion of glycosylated asparagine residues upon deglycosylation with PGNase F in H2O. CAUTION - the difference formula appears to be based on a partial structure [JSG]. Deamidated UniMod-interim Deamidation UniMod-description DiffAvg 0.98 DiffFormula H -1 N -1 O 1 DiffMono 0.984016 Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin N Source artifact TermSpec none MOD:00903 PSI-MOD MOD:00566 label cysteine with IGBP reagent modification from UniMod Chemical derivative 243 UniMod "IDBEST tag for quantitation, http://www.targetdiscovery.com/index.php?topic=prod.idbe" IGBP PSI-MS-label Light IDBEST tag for quantitation UniMod-description DiffAvg 297.15 DiffFormula Br 1 C 12 H 13 N 2 O 2 DiffMono 296.016040 Formula Br 1 C 15 H 18 N 3 O 3 S 1 MassAvg 400.29 MassMono 399.025225 Origin C Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00567 histidine oxidation to asparagine OBSOLETE because UniMod entry 244 is redundant with UniMod 348. Remap to MOD:00775. 29956 ChEBI 15736973 PubMed 5681232 PubMed 6692818 PubMed 9789001 PubMed AA0003 RESID 244 UniMod DiffAvg -23.04 DiffFormula C -2 H -1 N -1 O 1 DiffMono -23.015984 Formula none MassAvg none MassMono none Origin H Source artifact TermSpec none 1 PSI-MOD MOD:00568 histidine oxidation to aspartic acid OBSOLETE because UniMod entry 245 is redundant with UniMod 349. Remap to MOD:00776 1097438 PubMed 339692 PubMed 4399050 PubMed 5764436 PubMed 6692818 PubMed 8089117 PubMed 9521123 PubMed 9582379 PubMed 245 UniMod DiffAvg -22.05 DiffFormula C -2 H -2 N -2 O 2 DiffMono -22.031969 Formula none MassAvg none MassMono none Origin H Source artifact TermSpec none 1 PSI-MOD MOD:00569 residues isobaric at a resolution below 0.000001 Da Natural or modified residues that are isobaric at a resolution below 0.000001 Da. 18688235 PubMed PSI-MOD-slim MOD:00770 PSI-MOD MOD:00570 residues isobaric at 71.037114 Da Natural or modified residues with a mass of 71.037114 Da. 18688235 PubMed MOD:00569 MOD:00769 PSI-MOD MOD:00571 2-pyrrolidone-5-carboxylic acid (Pro) A modification that effectively oxygenates C5 of an L-proline residue to form a 2-pyrrolidone-5-carboxylic acid, pyroglutamic acid. 9252331 PubMed 359 UniMod The review article PubMed:9252331 does not provide an original citation for this modification [JSG]. Pro->pyro-Glu PSI-MS-label PyrGlu(Pro) PSI-MOD-label Pyroglutamic UniMod-interim pyroglutamicp OMSSA-label DiffAvg 13.98 DiffFormula H -2 O 1 DiffMono 13.979265 Formula C 5 H 6 N 1 O 2 MassAvg 112.11 MassMono 112.039853 Origin P Source artifact TermSpec none MOD:00679 MOD:00915 MOD:01048 PSI-MOD MOD:00572 oxidized arginine biotinylated with biotin hydrazide modification from UniMod Chemical derivative 15174056 PubMed 15828771 PubMed 343 UniMod Argbiotinhydrazide UniMod-interim oxidized Arginine biotinylated with biotin hydrazide UniMod-description DiffAvg 199.27 DiffFormula C 9 H 13 N 1 O 2 S 1 DiffMono 199.066700 Formula C 15 H 25 N 5 O 3 S 1 MassAvg 355.46 MassMono 355.167811 Origin R Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00573 oxidized lysine biotinylated with biotin hydrazide modification from UniMod Chemical derivative 15174056 PubMed 353 UniMod "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" Lysbiotinhydrazide UniMod-interim oxidized Lysine biotinylated with biotin hydrazide UniMod-description DiffAvg 241.31 DiffFormula C 10 H 15 N 3 O 2 S 1 DiffMono 241.088498 Formula C 16 H 27 N 5 O 3 S 1 MassAvg 369.48 MassMono 369.183461 Origin K Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00574 oxidized proline biotinylated with biotin hydrazide modification from UniMod Chemical derivative 15174056 PubMed 357 UniMod "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" oxidized proline biotinylated with biotin hydrazide UniMod-description probiotinhydrazide UniMod-interim DiffAvg 258.34 DiffFormula C 10 H 18 N 4 O 2 S 1 DiffMono 258.115047 Formula C 15 H 25 N 5 O 3 S 1 MassAvg 355.46 MassMono 355.167811 Origin P Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00575 oxidized threonine biotinylated with biotin hydrazide modification from UniMod Chemical derivative 15174056 PubMed 361 UniMod "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" oxidized Threonine biotinylated with biotin hydrazide UniMod-description Thrbiotinhydrazide UniMod-interim DiffAvg 240.32 DiffFormula C 10 H 16 N 4 O 1 S 1 DiffMono 240.104482 Formula C 14 H 23 N 5 O 3 S 1 MassAvg 341.43 MassMono 341.152161 Origin T Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00576 crotonaldehyde modification from UniMod Other 11283024 PubMed 253 UniMod Crotonaldehyde PSI-MS-label Crotonaldehyde UniMod-description DiffAvg 70.09 DiffFormula C 4 H 6 O 1 DiffMono 70.041865 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00577 acetaldehyde +26 modification from UniMod Other 7744761 PubMed 254 UniMod Acetaldehyde +26 UniMod-description Delta:H(2)C(2) PSI-MS-label DiffAvg 26.04 DiffFormula C 2 H 2 DiffMono 26.015650 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00578 acetaldehyde +28 modification from UniMod Other 255 UniMod Acetaldehyde +28 UniMod-description Delta:H(4)C(2) PSI-MS-label DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00579 propionaldehyde +40 modification from UniMod Other 256 UniMod Delta:H(4)C(3) PSI-MS-label Propionaldehyde +40 UniMod-description DiffAvg 40.06 DiffFormula C 3 H 4 DiffMono 40.031300 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00580 propionaldehyde +42 OBSOLETE because entry removed from UniMod. Remap potentially to MOD:00579 propionaldehyde +40 257 UniMod DiffAvg 42.08 DiffFormula C 3 H 6 DiffMono 42.046950 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none 1 PSI-MOD MOD:00581 (18)O monosubstituted residue A protein modification that effectively substitutes one (18)O atom for one (16)O atom. 11467524 PubMed 258 UniMod PSI-MOD-slim ctermpepo18 OMSSA-label Label:18O(1) PSI-MS-label O18 Labeling UniMod-description DiffAvg 2.00 DiffFormula (16)O -1 (18)O 1 DiffMono 2.004246 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec C-term MOD:00845 PSI-MOD MOD:00582 6x(13)C,2x(15)N labeled L-lysine A protein modification that effectively converts an L-lysine residue to 6x(13)C,2x(15)N labeled L-lysine. 12716131 PubMed 259 UniMod 13C(6) 15N(2) Silac label UniMod-description Label:13C(6)15N(2) PSI-MS-label lys-13C615N2 OMSSA-label DiffAvg 8.01 DiffFormula (12)C -6 (13)C 6 (14)N -2 (15)N 2 DiffMono 8.014199 Formula (13)C 6 H 12 (15)N 2 O 1 MassAvg 136.11 MassMono 136.109162 Origin K Source artifact TermSpec none MOD:00842 MOD:00843 MOD:00912 PSI-MOD MOD:00583 thiophosphorylated residue A protein modification that effectively replaces a hydrogen atom with a thiophosphono group (H2PO2S, 'thiophosphate'). 12110917 PubMed 260 UniMod Thiophospho PSI-MS-label Thiophosphorylation UniMod-description DiffAvg 96.04 DiffFormula H 1 O 2 P 1 S 1 DiffMono 95.943487 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00860 MOD:00861 PSI-MOD MOD:00584 4-sulfophenyl isothiocyanate derivatized residue A protein modification produced by formation of an adduct with 4-sulfophenyl isothiocyanate. 14689565 PubMed 14745769 PubMed 16526082 PubMed 261 UniMod 4-sulfophenyl isothiocyanate UniMod-description SPITC PSI-MS-label DiffAvg 215.24 DiffFormula C 7 H 5 N 1 O 3 S 2 DiffMono 214.971085 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00841 PSI-MOD MOD:00585 deuterium trisubstituted residue A protein modification that effectively substitutes three (2)H deuterium atoms for three (1)H protium atoms. 262 UniMod D(H)3Res PSI-MOD-label Label:2H(3) PSI-MS-label Trideuteration UniMod-description DiffAvg 3.02 DiffFormula (1)H -3 (2)H 3 DiffMono 3.018830 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00786 PSI-MOD MOD:00586 phosphorylation to pyridyl thiol modification from UniMod Chemical derivative 264 UniMod PET PSI-MS-label phosphorylation to pyridyl thiol UniMod-description DiffAvg 121.20 DiffFormula C 7 H 7 N 1 O -1 S 1 DiffMono 121.035006 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00587 6x(13)C,4x(15)N labeled L-arginine A protein modification that effectively converts an L-arginine residue to 6x(13)C, 4x(15)N labeled L-arginine. 12716131 PubMed 267 UniMod PSI-MOD-slim 13C(6) 15N(4) Silac label UniMod-description arg-13c6-15n4 OMSSA-label Label:13C(6)15N(4) PSI-MS-label DiffAvg 10.01 DiffFormula (12)C -6 (13)C 6 (14)N -4 (15)N 4 DiffMono 10.008269 Formula (13)C 6 H 12 (15)N 4 O 1 MassAvg 166.11 MassMono 166.109380 Origin R Source artifact TermSpec none MOD:00842 MOD:00843 MOD:00902 PSI-MOD MOD:00588 5x(13)C,1x(15)N labeled L-valine A protein modification that effectively converts an L-valine residue to 5x(13)C,1x(15)N labeled L-valine. 12771378 PubMed 268#V UniMod 13C(5) 15N(1) Silac label UniMod-description Label:13C(5)15N(1) PSI-MS-label DiffAvg 6.01 DiffFormula (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono 6.013809 Formula (13)C 5 H 9 (15)N 1 O 1 MassAvg 105.08 MassMono 105.082223 Origin V Source artifact TermSpec none MOD:00920 MOD:01809 PSI-MOD MOD:00589 1x(13)C,1x(15)N labeled L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to (13)C,(15)N labeled L-phenylalanine. 12771378 PubMed 269 UniMod 13C(9) 15N(1) Silac label UniMod-description Label:13C(9)15N(1) PSI-MS-label DiffAvg 10.03 DiffFormula (12)C -9 (13)C 9 (14)N -1 (15)N 1 DiffMono 10.027228 Formula (13)C 9 H 9 (15)N 1 O 1 MassAvg 157.10 MassMono 157.095642 Origin F Source artifact TermSpec none MOD:00842 MOD:00843 MOD:00914 PSI-MOD MOD:00590 nucleophilic addtion to cytopiloyne modification from UniMod Chemical derivative 15549660 PubMed 270 UniMod Cytopiloyne PSI-MS-label nucleophilic addtion to cytopiloyne UniMod-description DiffAvg 362.38 DiffFormula C 19 H 22 O 7 DiffMono 362.136553 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00591 nucleophilic addition to cytopiloyne+H2O modification from UniMod Chemical derivative 15549660 PubMed 271 UniMod Cytopiloyne+water PSI-MS-label nucleophilic addition to cytopiloyne+H2O UniMod-description DiffAvg 380.39 DiffFormula C 19 H 24 O 8 DiffMono 380.147118 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00592 sulfonation of N-terminal modification from UniMod Chemical derivative 12705581 PubMed 15732931 PubMed 16046801 PubMed 272 UniMod CAF PSI-MS-label sulfonation of N-terminus UniMod-description DiffAvg 136.12 DiffFormula C 3 H 4 O 4 S 1 DiffMono 135.983030 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00003 PSI-MOD MOD:00593 covalent modification of lysine by omega-maleimido alkanoyl N-hydroxysuccinimido esters modification from UniMod Chemical derivative 273 UniMod J. Prot. Chem. 2, 263-277, 1983 covalent modification of lysine by cross-linking reagent UniMod-description Xlink:SSD PSI-MS-label DiffAvg 253.25 DiffFormula C 12 H 15 N 1 O 5 DiffMono 253.095023 Formula C 18 H 27 N 3 O 6 MassAvg 381.43 MassMono 381.189986 Origin K Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00594 residues isobaric at 113.047678 Da Natural or modified resiues with a mass of 113.047678 Da. 18688235 PubMed PSI-MOD-slim MOD:00569 MOD:00624 PSI-MOD MOD:00595 mannosylated residue A protein modification that effectively replaces a hydrogen atom with an manose group through a glycosidic bond 18688235 PubMed PSI-MOD-slim ManRes PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00434 MOD:00727 PSI-MOD MOD:00596 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS. 235 DeltaMass 8597590 PubMed 276 UniMod From DeltaMass: Average Mass: 183 Average Mass Change:183 References:We have found that AEBSF modifies many proteins by covalent attachment, preferentially on Tyr, and to a lesser extent on Lys, His, and the amino-terminus. These modifications were identified by electrospray MS of the proteins (adds 183 Da per AEBS-group) and by peptide mapping and MS/MS. All the proteins we examined were modified after 24 hrs. at 4 C with 1 mM AEBSF in TRIS, pH 8.0. The reaction is 10-20x slower at pH 7; however AEBSF is quite stable in aqueous solution and the extent of to which the protein is modified continues to increase for several days. We have seen the addition of 10 or more AEBS-groups to proteins after prolonged storage. We found no equivalent modification from PMSF, probably because it degrades so quickly. We no longer use AEBSF, and urge caution to those who do. To address the problem, Boehringer Mannheim (now Roche Molecular Biochemicals) introduced Pefabloc PLUS which includes an additional component to compete for these side reactions. In our limited experience with Pefabloc PLUS, it reduces the +183 modifications, but does not always eliminate them. As a result, we prefer PMSF, despite its own set of drawbacks. We have never found PMSF-induced modification of proteins (except trypsin), probably due to its short half-life in aqeous solution. AEBS PSI-MS-label AEBSF DeltaMass-label Aminoethylbenzenesulfonylation UniMod-description DiffAvg 183.23 DiffFormula C 8 H 9 N 1 O 2 S 1 DiffMono 183.035400 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01652 PSI-MOD MOD:00597 methyl methanethiosulfonate OBSOLETE because UniMod entry 277 redundant with UniMod 39. Remap to MOD:00110. 277 UniMod DiffAvg 46.09 DiffFormula C 1 H 2 S 1 DiffMono 45.987721 Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none 1 PSI-MOD MOD:00598 S-(2-hydroxyethyl)cysteine A protein modification that effectively converts an L-cysteine residue to S-(2-hydroxyethyl)cysteine 15351294 PubMed 278 UniMod This modification of cysteine is produced by the reagent iodoethanol with triethylphosphine [JSG]. PSI-MOD-slim Ethanolation of Cys UniMod-description Ethanolyl PSI-MS-label DiffAvg 44.05 DiffFormula C 2 H 4 O 1 DiffMono 44.026215 Formula C 5 H 9 N 1 O 2 S 1 MassAvg 147.19 MassMono 147.035400 Origin C Source artifact TermSpec none MOD:00905 PSI-MOD MOD:00599 monomethylated residue A protein modification that effectively replaces one hydrogen atom with one methyl group. 11875433 PubMed 34 UniMod PSI-MOD-slim Me1Res PSI-MOD-label Methyl PSI-MS-label Methylation UniMod-description DiffAvg 14.03 DiffFormula C 1 H 2 DiffMono 14.015650 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00427 PSI-MOD MOD:00600 L-glutamic acid 5-ethyl ester A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-ethyl ester. 0 DeltaMass 9629898 PubMed 280#E UniMod From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation. For dimethylated residues, see MOD:00429 and its children [JSG]. Ethyl DeltaMass-label Ethyl PSI-MS-label Ethylation UniMod-description DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula C 7 H 11 N 1 O 3 MassAvg 157.17 MassMono 157.073893 Origin E Source artifact TermSpec none MOD:00906 MOD:01339 PSI-MOD MOD:00601 cyclized residue A protein modification that effectively produces an heterocyclic amino acid with a covalent bond between the side chain and either its alpha amino or 1-carboxyl group, possibly breaking the peptide chain. 18688235 PubMed PSI-MOD-slim CycRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00602 N-methylated residue A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with an methyl group. 18688235 PubMed PSI-MOD-slim NMeRes PSI-MOD-label MOD:00427 PSI-MOD MOD:00603 N-ethylation OBSOLETE because UniMod entry 283 is redundant with UniMod 280. Remap to MOD:00600 283 UniMod DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term 1 PSI-MOD MOD:00604 2x(2)H monomethylated L-lysine A protein modification that effectively converts an L-lysine residue to 2x(2)H labeled monomethylated L-lysine. 15525938 PubMed 284 UniMod Deuterium Methylation of Lysine UniMod-description Methyl:2H(2) PSI-MS-label DiffAvg 16.03 DiffFormula C 1 (2)H 2 DiffMono 16.028204 Formula C 7 (1)H 12 (2)H 2 N 2 O 1 MassAvg 144.12 MassMono 144.123167 Origin K Source artifact TermSpec none MOD:00839 MOD:00912 derives_from MOD:000850 PSI-MOD MOD:00605 Sulfanilic Acid (SA), light C12 modification from UniMod Chemical derivative, C-Terminal/Glutamate/Aspartate sulfonation 285 UniMod Light Sulfanilic Acid (SA) C12 UniMod-description SulfanilicAcid PSI-MS-label DiffAvg 155.17 DiffFormula C 6 H 5 N 1 O 2 S 1 DiffMono 155.004099 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec C-term MOD:01426 PSI-MOD MOD:00606 Sulfanilic Acid (SA), heavy C13 modification from UniMod Chemical derivative 9254591 PubMed 286 UniMod Heavy Sulfanilic Acid (SA) C13 UniMod-description SulfanilicAcid:13C(6) PSI-MS-label DiffAvg 161.02 DiffFormula (13)C 6 H 5 N 1 O 2 S 1 DiffMono 161.024228 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec C-term MOD:01426 PSI-MOD MOD:00607 dioxoindolealanine lactone modification from UniMod Chemical derivative 7949339 PubMed 288 UniMod UniMod name, formula, and terminal specification corrected. Formula corresponded to uncleaved intermediate [JSG]. Trp->Oxolactone PSI-MS-label Tryptophan oxidation to oxolactone UniMod-description DiffAvg 30.99 DiffFormula H -1 O 2 DiffMono 30.982004 Formula C 11 H 9 N 2 O 3 MassAvg 217.20 MassMono 217.061317 Origin W Source artifact TermSpec C-term MOD:00918 PSI-MOD MOD:00608 biotin polyethyleneoxide amine modification from UniMod Chemical derivative 289 UniMod Biotin polyethyleneoxide amine UniMod-description Biotin-PEO-Amine UniMod-interim DiffAvg 356.49 DiffFormula C 16 H 28 N 4 O 3 S 1 DiffMono 356.188212 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00609 Pierce EZ-Link Biotin-HPDP modification from UniMod Chemical derivative 290 UniMod Biotin-HPDP UniMod-interim Pierce EZ-Link Biotin-HPDP UniMod-description DiffAvg 428.61 DiffFormula C 19 H 32 N 4 O 3 S 2 DiffMono 428.191583 Formula C 22 H 37 N 5 O 4 S 3 MassAvg 531.75 MassMono 531.200768 Origin C Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00610 cysteinyl mercury modification from UniMod Chemical derivative 10695144 PubMed 291 UniMod Delta:Hg(1) PSI-MS-label Mercury Mercaptan UniMod-description DiffAvg 200.59 DiffFormula Hg 1 DiffMono 201.970643 Formula C 3 H 5 Hg 1 N 1 O 1 S 1 MassAvg 303.73 MassMono 304.979828 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 MOD:01075 PSI-MOD MOD:00611 iodouridine monophosphate derivatized residue A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with a residue. 11112526 PubMed 11567090 PubMed 6540775 PubMed 292 UniMod Cross-link of (Iodo)-uracil MP with W,F,Y UniMod-description IodoU-AMP PSI-MS-label DiffAvg 322.17 DiffFormula C 9 H 11 N 2 O 9 P 1 DiffMono 322.020217 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00612 3-(carboxamidomethylthio)propanoylated residue A protein modification that is produced by derivatization of a residue with 3,3-dithiobis[sulfosuccinimidyl propanoate], DTSSP, or with Pierce EZ-Link Sulfo-NHS-SS-Biotin reagent, sulfosuccinimidyl 3-[(2-[biotinamido]ethyl)disulfanyl]propanoate, followed by reduction with dithiothreitol and then reaction with iodoacetamide. 15121203 PubMed 293 UniMod 3-(carbamidomethylthio)propanoyl UniMod-description CAMthiopropanoyl PSI-MS-label DiffAvg 145.18 DiffFormula C 5 H 7 N 1 O 2 S 1 DiffMono 145.019749 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00649 MOD:00848 PSI-MOD MOD:00613 biotinoyl-iodoacetyl-ethylenediamine modification from UniMod Chemical derivative 10906242 PubMed 294 UniMod biotinoyl-iodoacetyl-ethylenediamine UniMod-description IED-Biotin PSI-MS-label DiffAvg 326.42 DiffFormula C 14 H 22 N 4 O 3 S 1 DiffMono 326.141262 Formula C 17 H 27 N 5 O 4 S 2 MassAvg 429.55 MassMono 429.150446 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00614 fucosylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a fucose (6-deoxy-D-galactose) group through a glycosidic bond. 11344537 PubMed 15189151 PubMed 295 UniMod PSI-MOD-slim dHex PSI-MS-label Fuc PSI-MOD-label Fucose UniMod-description DiffAvg 146.14 DiffFormula C 6 H 10 O 4 DiffMono 146.057909 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00736 PSI-MOD MOD:00615 4-sulfophenyl isothiocyante modification to N-term R OBSOLETE because entry UniMod:261 site N-term R was abandoned. Remap to MOD:00584 261 site N-term R was abandoned. Remap to MOD:00584" [PubMed:14689565 UniMod 261 UniMod DiffAvg 215.24 DiffFormula C 7 H 5 N 1 O 3 S 2 DiffMono 214.971085 Formula none MassAvg none MassMono none Origin R Source artifact TermSpec N-term 1 PSI-MOD MOD:00616 residues isobaric at a resolution below 0.1 Da Natural or modified residues that are isobaric at a resolution below 0.1 Da. 18688235 PubMed PSI-MOD-slim MOD:00538 PSI-MOD MOD:00617 3x(2)H residue methyl ester A protein modification that effectively converts a residue containing common isotopes to a 3x(2)H labeled residue methyl ester. 298 UniMod ctermpeptrideuteromethyl OMSSA-label deuterated methyl ester UniMod-description Methyl:2H(3) PSI-MS-label DiffAvg 17.03 DiffFormula C 1 (1)H -1 (2)H 3 DiffMono 17.034480 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec C-term MOD:00839 PSI-MOD MOD:00618 tryptophan carboxylation modification from UniMod Chemical derivative 299#W UniMod There is no literature citation for this UniMod entry [JSG]. Carboxy UniMod-interim Carboxylation UniMod-description DiffAvg 44.01 DiffFormula C 1 O 2 DiffMono 43.989829 Formula C 12 H 10 N 2 O 3 MassAvg 230.22 MassMono 230.069142 Origin W Source artifact TermSpec none MOD:00918 MOD:01152 PSI-MOD MOD:00619 hydroxylethanone OBSOLETE because entry 300 is redundant with UniMod 6 remap to MOD:01328 300 UniMod DiffAvg 58.04 DiffFormula C 2 H 2 O 2 DiffMono 58.005479 Formula none MassAvg none MassMono none Origin W Source artifact TermSpec none 1 PSI-MOD MOD:00620 cysteine monobromobimane derivative modification from UniMod Chemical derivative 7856876 PubMed 301 UniMod 1-(bromomethyl)-2,6,7-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione, C 10 H 11 Br 1 N 2 O 2. Bromobimane PSI-MS-label Monobromobimane derivative UniMod-description DiffAvg 190.20 DiffFormula C 10 H 10 N 2 O 2 DiffMono 190.074228 Formula C 13 H 15 N 3 O 3 S 1 MassAvg 293.34 MassMono 293.083412 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00621 menadione quinone derivative modification from UniMod Chemical derivative 15939799 PubMed 302 UniMod Menadione UniMod-interim Menadione quinone derivative UniMod-description DiffAvg 170.17 DiffFormula C 11 H 6 O 2 DiffMono 170.036779 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00622 cysteine mercaptoethanol modification from UniMod Chemical derivative 80 DeltaMass 12442261 PubMed 303 UniMod From DeltaMass: Average Mass: 76 Average Mass Change:76 PubMed:8019414. Beta mercaptoethanol adduct DeltaMass-label Cysteine mercaptoethanol UniMod-description DeStreak PSI-MS-label DiffAvg 76.11 DiffFormula C 2 H 4 O 1 S 1 DiffMono 75.998286 Formula C 5 H 9 N 1 O 2 S 2 MassAvg 179.25 MassMono 179.007471 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00623 fucosylated biantennary (-2 galactose) modification from UniMod N-linked glycosylation 305 UniMod dHex(1)Hex(3)HexNAc(4) PSI-MS-label Fucosylated biantennary (-2 galactose) UniMod-description DiffAvg 1443.33 DiffFormula C 56 H 90 N 4 O 39 DiffMono 1442.518219 Formula C 60 H 96 N 6 O 41 MassAvg 1557.43 MassMono 1556.561147 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00624 residues isobaric at 113.0-113.1 Da Natural or modified residues with a mass of 113.0-113.1 Da. 18688235 PubMed PSI-MOD-slim MOD:00616 PSI-MOD MOD:00625 N-methylmaleimide derivatized residue modification from UniMod Chemical derivative 314 UniMod Nmethylmaleimide PSI-MS-label Nmethylmaleimide UniMod-description DiffAvg 111.10 DiffFormula C 5 H 5 N 1 O 2 DiffMono 111.032028 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00626 fluorescein-5-thiosemicarbazide modification from UniMod Chemical derivative 2883911 PubMed 478 UniMod fluorescein-5-thiosemicarbazide UniMod-description FTC PSI-MS-label DiffAvg 421.43 DiffFormula C 21 H 15 N 3 O 5 S 1 DiffMono 421.073242 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00627 2,5-dimethylpyrrole lysine from 2,5-hexanedione adduct modification from UniMod Chemical derivative 316 UniMod There is no citation for this UniMod entry. Add PubMed:7981420, correct spelling [JSG]. (2S)-2-amino-6-(2,5-dimethylpyrrolidin-1-yl)hexanoic acid PSI-MOD-alternate 2,5-dimethypyrrole UniMod-description 6-(2,5-dimethylpyrrolidin-1-yl)norleucine PSI-MOD-alternate DimethylpyrroleAdduct PSI-MS-label DiffAvg 78.11 DiffFormula C 6 H 6 DiffMono 78.046950 Formula C 12 H 18 N 2 O 1 MassAvg 206.29 MassMono 206.141913 Origin K Source artifact TermSpec none MOD:00848 MOD:00912 PSI-MOD MOD:00628 Hex2 a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with two hexose sugar groups through glycosidic bonds 18688235 PubMed DiffAvg 324.28 DiffFormula C 12 H 20 O 10 DiffMono 324.105647 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00725 PSI-MOD MOD:00629 MDA adduct +62 modification from UniMod Chemical derivative 318 UniMod Usually major adduct formed from malondialdehyde (MDA) with the amino group of lysine residues [UniProt]. Delta:H(2)C(5) PSI-MS-label MDA adduct +62 UniMod-description DiffAvg 62.07 DiffFormula C 5 H 2 DiffMono 62.015650 Formula C 11 H 14 N 2 O 1 MassAvg 190.25 MassMono 190.110613 Origin K Source artifact TermSpec none MOD:00848 MOD:00912 PSI-MOD MOD:00630 C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. modification from UniMod Chemical derivative 9328283 PubMed 319 UniMod This is not a legitimate ontological entry and will become obsolete when the children are reassigned [JSG] Delta:H(2)C(3)O(1) PSI-MS-label MDA adduct +54 UniMod-description DiffAvg 54.05 DiffFormula C 3 H 2 O 1 DiffMono 54.010565 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00631 hydrolyzed N-ethylmaleimide adduct modification from UniMod Chemical derivative 320 UniMod N-ethylmaeimide adduct + H20 (a mixture of isobaric products) [JSG]. Nethylmaleimide+water PSI-MS-label Nethylmaleimidehydrolysis UniMod-description DiffAvg 143.14 DiffFormula C 6 H 9 N 1 O 3 DiffMono 143.058243 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00632 N-succinimide OBSOLETE because this chemical derivative modification from UniMod 321 is deprecated. 321 UniMod DiffAvg -17.01 DiffFormula H -1 O -1 DiffMono -17.002740 Formula none MassAvg none MassMono none Origin N Source artifact TermSpec none 1 PSI-MOD MOD:00633 bis-N-I-sulfonerahodamine modification from UniMod Chemical derivative 323 UniMod Invitrogen B-10621, a red fluorescent cross-linking reagent (only link to Cys is indicated) [UniMod]. bis-((N-iodoacetyl)piperazinyl)sulfonerhodamine PSI-MOD-alternate bis-N-I-sulfonerahodamine UniMod-description Xlink:B10621 PSI-MS-label DiffAvg 713.57 DiffFormula C 31 H 30 I 1 N 4 O 6 S 1 DiffMono 713.093078 Formula C 34 H 35 I 1 N 5 O 7 S 2 MassAvg 816.71 MassMono 816.102263 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00634 dimethyl 3,3'-dithiobispropionimidate modification from UniMod Chemical derivative 770170 PubMed 324 UniMod Pierce reagent, needs sites for N, Q, R, K, and N-term [JSG]. dimethyl 3,3'-dithiobispropionimidate UniMod-description DTBP UniMod-interim DiffAvg 123.60 DiffFormula C 3 Cl 1 H 6 N 1 S 1 DiffMono 122.990948 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00635 10-fluoroethoxyphosphinyl-N-(biotinamidopentyl)decanamide modification from UniMod Chemical derivative 10611275 PubMed 325 UniMod 10-ethoxyphosphinyl-N-(biotinamidopentyl)decanamide UniMod-description FP-Biotin UniMod-interim DiffAvg 572.75 DiffFormula C 27 H 49 N 4 O 5 P 1 S 1 DiffMono 572.316128 Formula C 30 H 54 N 5 O 7 P 1 S 1 MassAvg 659.82 MassMono 659.348157 Origin S Source artifact TermSpec none MOD:00848 MOD:00861 MOD:00916 PSI-MOD MOD:00636 S-ethylcysteine (Ser) A protein modification that effectively converts an L-serine residue to S-ethylcysteine. 327 UniMod Modification from UniMod. Phosphoserine is converted to dehydroalanine then by Michael addition of ethanethiol to S-ethylcysteine. Needs parent and sibling for S-ethyl-cysteine. Delta:H(4)C(2)O(-1)S(1) PSI-MS-label S-Ethylcystine from Serine UniMod-description DiffAvg 44.11 DiffFormula C 2 H 4 O -1 S 1 DiffMono 44.008457 Formula C 5 H 9 N 1 O 1 S 1 MassAvg 131.19 MassMono 131.040485 Origin S Source artifact TermSpec none MOD:00916 PSI-MOD MOD:00637 1x(13)C,3x(2)H labeled monomethylated L-arginine A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with a (13)C,3x(2)H labeled methyl group to form a 1x(13)C,3x(2)H labeled monomethylated L-arginine. 329 UniMod Methyl:2H(3)13C(1) PSI-MS-label monomethylated arginine UniMod-description DiffAvg 18.04 DiffFormula (13)C 1 (1)H -1 (2)H 3 DiffMono 18.037835 Formula (12)C 6 (13)C 1 (1)H 11 (2)H 3 N 4 O 1 MassAvg 174.14 MassMono 174.138946 Origin R Source artifact TermSpec none MOD:00839 MOD:00842 MOD:00902 derives_from MOD:004140 PSI-MOD MOD:00638 2x(13)C,6x(2)H labeled dimethylated L-arginine A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-arginine. 15782174 PubMed 330 UniMod Dimethyl:2H(6)13C(2) PSI-MS-label dimethylated arginine UniMod-description DiffAvg 36.08 DiffFormula (13)C 2 (1)H -2 (2)H 6 DiffMono 36.075670 Formula (12)C 6 (13)C 2 (1)H 10 (2)H 6 N 4 O 1 MassAvg 192.18 MassMono 192.176781 Origin R Source artifact TermSpec none MOD:00839 MOD:00842 MOD:00902 derives_from MOD:007830 PSI-MOD MOD:00639 thiophosphate labeled with biotin-HPDP modification from UniMod Chemical derivative 332 UniMod Thiophos-S-S-biotin PSI-MS-label thiophosphate labeled with biotin-HPDP UniMod-description DiffAvg 525.66 DiffFormula C 19 H 34 N 4 O 5 P 1 S 3 DiffMono 525.142895 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 MOD:00861 PSI-MOD MOD:00640 6-N-biotinylaminohexyl isopropyl phosphorofluoridate modification from UniMod Chemical derivative 333 UniMod 6-N-biotinylaminohexyl isopropyl phosphate UniMod-description Can-FP-biotin UniMod-interim DiffAvg 467.54 DiffFormula C 19 F 1 H 35 N 3 O 5 P 1 S 1 DiffMono 467.201907 Formula C 22 F 1 H 40 N 4 O 7 P 1 S 1 MassAvg 554.62 MassMono 554.233935 Origin S Source artifact TermSpec none MOD:00848 MOD:00861 MOD:00916 PSI-MOD MOD:00641 CAMthiopropanoyl of Lys OBSOLETE because UniMod entry 334 is merged with UniMod 293. Remap to MOD:00612 334 UniMod DiffAvg 146.18 DiffFormula C 5 H 8 N 1 O 2 S 1 DiffMono 146.027574 Formula none MassAvg none MassMono none Origin K Source artifact TermSpec none 1 PSI-MOD MOD:00642 reduced 4-hydroxynonenal adduct A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. 11910026 PubMed 15133838 PubMed 335 UniMod 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. HNE+Delta:H(2) PSI-MS-label reduced 4-Hydroxynonenal UniMod-description DiffAvg 158.24 DiffFormula C 9 H 18 O 2 DiffMono 158.130680 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 MOD:01155 derives_from MOD:004460 PSI-MOD MOD:00643 methylamine Michael addition derivatized residue modification from UniMod Artifact 11968134 PubMed 337 UniMod Methylamine PSI-MS-label Michael addition with methylamine UniMod-description DiffAvg 13.04 DiffFormula C 1 H 3 N 1 O -1 DiffMono 13.031634 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00003 PSI-MOD MOD:00644 O-acetylated residue A protein modification that effectively replaces a residue hydroxyl group with an acetoxy group. 18688235 PubMed PSI-MOD-slim OAcRes PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 O 1 DiffMono 42.010565 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00394 MOD:00671 PSI-MOD MOD:00645 S-acetylated residue A protein modification that effectively replaces a residue sulfanyl group with an acetylsulfanyl group. 18688235 PubMed PSI-MOD-slim SAcRes PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 O 1 S 0 DiffMono 42.010565 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00394 MOD:00672 PSI-MOD MOD:00646 acetylated L-cysteine A protein modification that effectively converts an L-cysteine residue to either N-acetyl-L-cysteine or S-acetyl-L-cysteine. 18688235 PubMed PSI-MOD-slim AcCys PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 S 0 DiffMono 42.010565 Formula C 5 H 7 N 1 O 2 S 1 MassAvg 145.18 MassMono 145.019749 Origin C Source natural MOD:00394 MOD:00905 PSI-MOD MOD:00647 acetylated L-serine A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine. 18688235 PubMed PSI-MOD-slim AcSer PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula none MassAvg none MassMono none Origin S Source natural MOD:00394 MOD:00916 PSI-MOD MOD:00648 N,O-diacetylated L-serine A protein modification that effectively converts an L-serine residue to N,O-diacetyl-L-serine. 16731519 PubMed 489587 PubMed 7309355 PubMed AA0051#var RESID AA0364#var RESID The samples were prepared using glacial acetic acid, and were probably artifactual [JSG]. (S)-2-acetamido-3-acetyloxypropanoic acid PSI-MOD-alternate N,O-diacetyl-L-serine PSI-MOD-alternate N,O-diacetylserine PSI-MOD-alternate NOAc2Ser PSI-MOD-label DiffAvg 84.07 DiffFormula C 4 H 4 N 0 O 2 DiffMono 84.021129 Formula C 7 H 10 N 1 O 4 MassAvg 172.16 MassMono 172.060983 Origin S Source artifact TermSpec N-term MOD:00408 MOD:00644 MOD:00647 has_functional_parent MOD:000600 has_functional_parent MOD:003690 PSI-MOD MOD:00649 acylated residue A protein modification that effectively replaces a hydrogen atom with an acyl group. 18688235 PubMed PSI-MOD-slim AcylRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00650 N-myristoylated residue A protein modification that effectively replaces a residue amino group with a myristoylamino group. 18688235 PubMed PSI-MOD-slim NMyrRes PSI-MOD-label DiffAvg 210.36 DiffFormula C 14 H 26 O 1 DiffMono 210.198365 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00438 MOD:00670 PSI-MOD MOD:00651 N-palmitoylated residue A protein modification that effectively replaces a residue amino group with a palmitoylamino group. 18688235 PubMed PSI-MOD-slim NPamRes PSI-MOD-label DiffAvg 238.41 DiffFormula C 16 H 30 O 1 DiffMono 238.229666 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00440 MOD:00670 PSI-MOD MOD:00652 O-palmitoylated residue A protein modification that effectively replaces a residue hydroxyl group with a palmitoyloxy group. 18688235 PubMed PSI-MOD-slim OPamRes PSI-MOD-label DiffAvg 238.41 DiffFormula C 16 H 30 O 1 DiffMono 238.229666 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00440 MOD:00671 PSI-MOD MOD:00653 S-palmitoylated residue A protein modification that effectively replaces a residue sulfanyl group with an palmitoylsulfanyl group. 18688235 PubMed PSI-MOD-slim SPamRes PSI-MOD-label DiffAvg 238.41 DiffFormula C 16 H 30 O 1 S 0 DiffMono 238.229666 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00440 MOD:00672 PSI-MOD MOD:00654 S-methylated residue a protein modification that effectively replaces a sulfanyl group with a methylsulfanyl group 18688235 PubMed PSI-MOD-slim SMeRes PSI-MOD-label MOD:00427 PSI-MOD MOD:00655 S-myristoylated residue A protein modification that effectively replaces a residue sulfanyl group with an myristoylsulfanyl group. 18688235 PubMed SMyrRes PSI-MOD-label DiffAvg 210.36 DiffFormula C 14 H 26 O 1 S 0 DiffMono 210.198365 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00438 MOD:00672 PSI-MOD MOD:00656 C-methylated residue A protein modification that effectively replaces a residue hydrocarbyl hydrogen with an methyl group. 18688235 PubMed CMeRes PSI-MOD-label MOD:00427 PSI-MOD MOD:00657 L-glutamic acid 5-methyl ester (Gln) A protein modification that effectively converts an L-glutamine residue to L-glutamate 5-methyl ester. 16888 PubMed 6300110 PubMed AA0072#GLN RESID 528 UniMod This is known to be a natural modification of glutamine in prokaryotes. PSI-MOD-slim (2S)-2-amino-5-methoxy-5-oxopentanoic acid RESID-systematic (5)-methyl L-hydrogen glutamate RESID-alternate 2-aminopentanedioic acid 5-methyl ester RESID-alternate 5-methyl L-2-aminoglutarate RESID-alternate 5-methyl L-glutamate RESID-alternate deamidated 5-methyl esterified glutamine PSI-MOD-alternate Deamidation followed by a methylation UniMod-description glutamic acid 5-methyl ester RESID-alternate glutamic acid gamma-methyl ester RESID-alternate L-glutamic acid 5-methyl ester RESID-name Methyl+Deamidated PSI-MS-label MOD_RES Glutamate methyl ester (Gln) UniProt-feature O5MeGlu(Gln) PSI-MOD-label DiffAvg 15.01 DiffFormula C 1 H 1 N -1 O 1 DiffMono 14.999666 Formula C 6 H 9 N 1 O 3 MassAvg 143.14 MassMono 143.058243 Origin Q Source natural TermSpec none MOD:01369 MOD:01453 has_functional_parent MOD:006590 PSI-MOD MOD:00658 methylated arginine A protein modification that effectively converts an L-arginine residue to a methylated arginine, either 5-methylargine, N5-methylarginine, or an omega-N-methylated L-arginine. 18688235 PubMed PSI-MOD-slim MeArg PSI-MOD-label Origin R MOD:00427 MOD:00902 PSI-MOD MOD:00659 methylated glutamine A protein modification that effectively converts an L-glutamine residue to a methylated glutamine, either 2-methylated glutamine, N5-methylated glutamine, or methyl esterified deamidated glutamine. 18688235 PubMed PSI-MOD-slim MeGln PSI-MOD-label Origin Q Source natural TermSpec none MOD:00427 MOD:00907 PSI-MOD MOD:00660 methylated cysteine A protein modification that effectively converts an L-cysteine residue to a methylated cysteine, either S-methylcysteine, or cysteine methyl ester. 18688235 PubMed PSI-MOD-slim MeCys PSI-MOD-label Origin C Source natural TermSpec none MOD:00427 MOD:00905 PSI-MOD MOD:00661 methylated histidine A protein modification that effectively converts an L-histidine residue to a methylated histidine, such as pros-methylhistidine, or tele-methylhistidine. 18688235 PubMed PSI-MOD-slim MeHis PSI-MOD-label Origin H Source natural TermSpec none MOD:00427 MOD:00909 PSI-MOD MOD:00662 methylated leucine A protein modification that effectively converts an L-leucine residue to a methylated leucine, either N-methylleucine, or leucine methyl ester. 18688235 PubMed PSI-MOD-slim MeLeu PSI-MOD-label Origin L Source natural TermSpec none MOD:00427 MOD:00911 PSI-MOD MOD:00663 methylated lysine A protein modification that effectively converts an L-lysine residue to a methylated lysine. 18688235 PubMed PSI-MOD-slim MeLys PSI-MOD-label Origin K Source natural TermSpec none MOD:00427 MOD:00912 PSI-MOD MOD:00664 stereoisomerized residue A protein modification that effectively replaces a residue L-enantiomer (stereoisomer) with a D-enantiomer or with a different diastereomeric isomer. 18688235 PubMed D-Res PSI-MOD-label MOD:01156 PSI-MOD MOD:00665 methylated alanine A protein modification that effectively converts an L-alanine residue to a methylated alanine, such as N-methylalanine, N,N-dimethylalanine, or N,N,N-trimethylalanine. 18688235 PubMed PSI-MOD-slim MeAla PSI-MOD-label Origin A Source natural TermSpec none MOD:00427 MOD:00901 PSI-MOD MOD:00666 octanoylated residue A protein modification that effectively replaces a hydrogen atom with an octanoyl group. 18688235 PubMed PSI-MOD-slim OctRes PSI-MOD-label DiffAvg 126.20 DiffFormula C 8 H 14 N 0 O 1 DiffMono 126.104465 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00649 MOD:01155 PSI-MOD MOD:00667 decanoylated residue A protein modification that effectively replaces a hydrogen atom with a decanoyl group. 18688235 PubMed DecRes PSI-MOD-label DiffAvg 154.25 DiffFormula C 10 H 18 N 0 O 1 DiffMono 154.135765 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00649 MOD:01155 PSI-MOD MOD:00668 O-decanoylated residue A protein modification that effectively replaces a residue hydroxyl group with a decanoyloxy group. 449 UniMod Decanoyl PSI-MS-label lipid UniMod-description ODecRes PSI-MOD-label DiffAvg 154.25 DiffFormula C 10 H 18 N 0 O 1 DiffMono 154.135765 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00667 MOD:00671 PSI-MOD MOD:00669 O-octanoylated residue A protein modification that effectively replaces a residue hydroxyl group with a octanoyloxy group. 426 UniMod PSI-MOD-slim Octanoyl PSI-MS-label octanoyl UniMod-description OOctRes PSI-MOD-label DiffAvg 126.20 DiffFormula C 8 H 14 N 0 O 1 DiffMono 126.104465 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00666 MOD:00671 PSI-MOD MOD:00670 N-acylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group. 18688235 PubMed PSI-MOD-slim NAcylRes PSI-MOD-label MOD:00649 PSI-MOD MOD:00671 O-acylated residue A protein modification that effectively replaces a residue hydroxyl group with a acyloxy group. 18688235 PubMed PSI-MOD-slim OAcylRes PSI-MOD-label MOD:00649 PSI-MOD MOD:00672 S-acylated residue A protein modification that effectively replaces a residue sulfanyl group with an acylsulfanyl group. 18688235 PubMed PSI-MOD-slim SAcylRes PSI-MOD-label MOD:00649 PSI-MOD MOD:00673 methylated asparagine A protein modification that effectively converts an L-asparagine residue to a methylated asparagine, such as N4-methyl-L-asparagine, or N4,N4-dimethyl-L-asparagine. 18688235 PubMed PSI-MOD-slim MeAsn PSI-MOD-label Origin N Source natural TermSpec none MOD:00427 MOD:00903 PSI-MOD MOD:00674 amidated residue A protein modification that effectively replaces a carboxyl group with a carboxamido group. 18688235 PubMed PSI-MOD-slim DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:01156 PSI-MOD MOD:00675 oxidized residue A protein modification that effectively either removes neutral hydrogen atoms (proton and electron), or adds oxygen atoms to a residue with or without the removal of hydrogen atoms. 18688235 PubMed PSI-MOD-slim OxRes PSI-MOD-label Origin X Source none TermSpec none MOD:01156 PSI-MOD MOD:00676 oxygenated residue A protein modification that effectively adds oxygen atoms to a residue with or without the removal of hydrogen atoms. 18688235 PubMed PSI-MOD-slim OxyRes PSI-MOD-label Origin X Source none TermSpec none MOD:00675 PSI-MOD MOD:00677 hydroxylated residue A protein modification that effectively replaces a hydrogen atom with an hydroxyl group. 0 DeltaMass From DeltaMass: Average Mass: 16 PSI-MOD-slim Hydroxylation (of delta C of Lysine, beta C of Tryptophan, C3 or C4 of Proline, beta C of Aspartate) DeltaMass-label HyRes PSI-MOD-label Origin X Source none TermSpec none MOD:00679 PSI-MOD MOD:00678 hydroxylated proline A protein modification that effectively converts an L-proline residue to an hydroxylated L-proline. 18688235 PubMed PSI-MOD-slim HyPro PSI-MOD-label Origin P Source none TermSpec none MOD:00677 MOD:00915 PSI-MOD MOD:00679 carbon oxygenated residue A protein modification that effectively adds oxygen atoms to a carbon atom of a residue and removes hydrogen atoms. 18688235 PubMed PSI-MOD-slim COxyRes PSI-MOD-label MOD:00676 PSI-MOD MOD:00680 sulfur oxygenated residue A protein modification that effectively adds oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms. 18688235 PubMed PSI-MOD-slim SOxyRes PSI-MOD-label MOD:00676 PSI-MOD MOD:00681 hydroxylated lysine A protein modification that effectively converts an L-lysine residue to a hydroxylated L-lysine. 18688235 PubMed PSI-MOD-slim HyLys PSI-MOD-label Origin K MOD:00677 MOD:00912 PSI-MOD MOD:00682 hydroxylated arginine A protein modification that effectively converts an L-arginine residue to a hydroxylated L-arginine. 18688235 PubMed HyArg PSI-MOD-label Origin R MOD:00677 MOD:00902 PSI-MOD MOD:00683 dehydrogenated residue A protein modification that effectively removes neutral hydrogen atoms (proton and electron) from a residue. 18688235 PubMed PSI-MOD-slim dHRes PSI-MOD-label Origin X MOD:00675 PSI-MOD MOD:00684 deamidated L-asparagine A protein modification that effectively converts an L-asparagine residue to L-aspartic acid. 1097438 PubMed 339692 PubMed 4399050 PubMed 5764436 PubMed 6692818 PubMed 8089117 PubMed 9521123 PubMed 9582379 PubMed AA0004#ASN RESID 7#N UniMod incidental to RESID:AA0059 PSI-MOD-slim (2S)-2-aminobutanedioic acid RESID-systematic 2-azanylbutanedioic acid RESID-alternate aminosuccinic acid RESID-alternate dNAsn PSI-MOD-label L-aspartic acid RESID-name MOD_RES Deamidated asparagine UniProt-feature DiffAvg 0.98 DiffFormula C 0 H -1 N -1 O 1 DiffMono 0.984016 Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin N Source natural TermSpec none MOD:00013 MOD:00400 MOD:00903 PSI-MOD MOD:00685 deamidated L-glutamine A protein modification that effectively converts an L-glutamine residue to L-glutamic acid. 1881881 PubMed 4565668 PubMed 4922541 PubMed 6692818 PubMed 9192900 PubMed 957425 PubMed AA0006#GLN RESID 7#Q UniMod PSI-MOD-slim (2S)-2-aminopentanedioic acid RESID-systematic 1-aminopropane-1,3-dicarboxylic acid RESID-alternate 2-aminoglutaric acid RESID-alternate 2-azanylpentanedioic acid RESID-alternate alpha-aminoglutaric acid RESID-alternate dNGln PSI-MOD-label glutaminic acid RESID-alternate L-glutamic acid RESID-name MOD_RES Deamidated glutamine UniProt-feature DiffAvg 0.98 DiffFormula C 0 H -1 N -1 O 1 DiffMono 0.984016 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin Q Source natural TermSpec none MOD:00015 MOD:00400 PSI-MOD MOD:00686 L-selenocysteine (Cys) A protein modification that effectively converts an L-cysteine residue to L-selenocysteine (not known as a natural, post-translational modification process). 10523135 PubMed 2037562 PubMed 2963330 PubMed 6217842 PubMed 6714945 PubMed AA0022#CYS RESID 162#C UniMod This entry is for the artifactual formation of L-selenocysteine from cysteine. For encoded L-selenocysteine, use MOD:00031 [JSG]. (2R)-2-amino-3-selanylpropanoic acid RESID-systematic 2-azanyl-3-selanylpropanoic acid RESID-alternate 3-selenylalanine RESID-alternate L-selenocysteine RESID-name NON_STD Selenocysteine UniProt-feature Sec(Cys) PSI-MOD-label SeCys RESID-alternate selenium cysteine RESID-alternate DiffAvg 46.91 DiffFormula C 0 H 0 N 0 O 0 S -1 Se 1 DiffMono 47.944450 Formula C 3 H 5 N 1 O 1 Se 1 MassAvg 150.05 MassMono 150.953635 Origin C Source artifact TermSpec none MOD:00007 MOD:00031 MOD:00905 PSI-MOD MOD:00687 thioether crosslinked residues A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and either an alkyl C as in lanthionine, or an aryl C as 2'-(S-cysteinyl)-L-histidine. 18688235 PubMed MOD:00033 MOD:00905 PSI-MOD MOD:00688 isopeptide crosslinked residues A protein modification that crosslinks two residues with an amide bond where either the donor amino or carboxyl is not an alpha group. 18688235 PubMed PSI-MOD-slim MOD:00033 PSI-MOD MOD:00689 disulfide crosslinked residues A protein modification that crosslinks two cysteine residues by formation of a disulfide bond. 18688235 PubMed PSI-MOD-slim MOD:01619 PSI-MOD MOD:00690 oxazole/thiazole ring crosslinked residues A protein modification that crosslinks two residues by formation of an oxazole or thiazole ring. 18688235 PubMed MOD:00033 PSI-MOD MOD:00691 5-imidazolinone ring crosslinked residues A protein modification that crosslinks two residues by formation of an 5-imidazolinone ring. 18688235 PubMed MOD:00033 PSI-MOD MOD:00692 uncategorized crosslinked residues A protein crosslink modification that is not chemically categorized. 18688235 PubMed PSI-MOD-slim MOD:00033 PSI-MOD MOD:00693 glycosylated residue A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond. 18688235 PubMed PSI-MOD-slim GlycoRes PSI-MOD-label Source natural MOD:00764 PSI-MOD MOD:00694 halogen containing residue A protein modification that effectively substitutes a halogen atom for a hydrogen atom. 18688235 PubMed PSI-MOD-slim halogenated residue PSI-MOD-alternate HalRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00695 sulfated residue A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group. 0 DeltaMass 14752058 PubMed 40 UniMod From DeltaMass: Average Mass: 80. PSI-MOD-slim O-Sulfonation UniMod-description Sulfo PSI-MS-label SulfRes PSI-MOD-label Sulphonation (SO3H) (of PMC group) DeltaMass-label DiffAvg 80.06 DiffFormula O 3 S 1 DiffMono 79.956815 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00860 PSI-MOD MOD:00696 phosphorylated residue A protein modification that effectively replaces a hydrogen atom with a phosphono group (H2PO3 or 'phosphate'). 0 DeltaMass 21 UniMod From DeltaMass: Average Mass: 80. PSI-MOD-slim Phospho PSI-MS-label Phosphorylation UniMod-description Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) DeltaMass-label PhosRes PSI-MOD-label DiffAvg 79.98 DiffFormula H 1 O 3 P 1 DiffMono 79.966331 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00861 PSI-MOD MOD:00697 flavin modified residue A protein modification that effectively results from forming an adduct with a compound containing a flavin group. 50 UniMod PSI-MOD-slim FAD PSI-MS-label Flavin adenine dinucleotide UniMod-description FlavRes PSI-MOD-label DiffAvg 783.54 DiffFormula C 27 H 31 N 9 O 15 P 2 S 0 DiffMono 783.141485 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:01156 PSI-MOD MOD:00698 metal or metal cluster containing modified residue A protein modification that effectively substitutes a metal atom or a metal cluster for hydrogen atoms, or coordinates a metal ion. 18688235 PubMed PSI-MOD-slim MetalRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00699 porphyrin modified residue A protein modification that effectively results from forming an adduct with a compound containing a porphyrin group. 18688235 PubMed PSI-MOD-slim PorphRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00700 tetrapyrrole modified residue A protein modification that effectively results from forming an adduct with a compound containing a tetrapyrrole group. 18688235 PubMed TetrapyrRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00701 nucleotide or nucleic acid modified residue A protein modification that effectively results from forming an adduct with a compound containing a nucleotide or a polynucleotide through formation of either a phosphodiester bond, a phosphoramide ester bond, or a glycosidic bond. 18688235 PubMed PSI-MOD-slim NucRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00702 isotope labeled residue A protein modification that effectively substitutes atoms of particular common isotopes with atoms or groups containing isotopes that are not the most common. 18688235 PubMed In SILAC (stable isotope labelling of amino acids in cell culture), the label may be introduced either through labeling of an incorporated residue or labeling of the substrates in a metabolic modification. For isotope labeling introduced through a modification reagent see MOD:01426. PSI-MOD-slim IsoTagRes PSI-MOD-label SILAC PSI-MOD-alternate MOD:01156 PSI-MOD MOD:00703 isoprenylated residue A protein modification that effectively replaces a hydrogen atom with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20) group. 18688235 PubMed PSI-MOD-slim IpRes PSI-MOD-label MOD:00001 MOD:01155 PSI-MOD MOD:00704 dehydrated residue A protein modification that effectively forms a double bond by removing a molecule of water from a residue. 0 DeltaMass 23 UniMod PSI-MOD-slim Dehydrated UniMod-interim Dehydration UniMod-description DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:01156 PSI-MOD MOD:00705 D-valine A protein modification that effectively converts an L-valine residue to D-valine. 30016 ChEBI 15853325 PubMed AA0200 RESID (R)-2-amino-3-methylbutanoic acid RESID-systematic alpha-amino-beta-methylbutyric acid RESID-alternate alpha-aminoisovaleric acid RESID-alternate D-Val PSI-MOD-label D-valine RESID-name MOD_RES D-valine UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 5 H 9 N 1 O 1 MassAvg 99.13 MassMono 99.068414 Origin V Source natural TermSpec none MOD:00664 PSI-MOD MOD:00706 dehydrogenated tyrosine A protein modification that effectively converts L-tyrosine to 2,3-didehydrotyrosine. 401#Y UniMod PSI-MOD-slim dHTyr PSI-MOD-label DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 9 H 7 N 1 O 2 MassAvg 161.16 MassMono 161.047678 Origin Y Source natural TermSpec none MOD:00919 MOD:01888 PSI-MOD MOD:00707 hydroxylated tyrosine a protein modification that effectively converts an L-tyrosine residue to a multihydroxylated L-phenylalanine 18688235 PubMed PSI-MOD-slim HyTyr PSI-MOD-label Origin Y Source natural TermSpec none MOD:00677 MOD:00919 PSI-MOD MOD:00708 sulfur oxygenated L-cysteine A protein modification that effectively adds oxygen atoms to a sulfur atom of L-cysteine residue without removing hydrogen atoms. 18688235 PubMed PSI-MOD-slim SOxyCys PSI-MOD-label Origin C Source artifact TermSpec none MOD:00680 MOD:00905 PSI-MOD MOD:00709 sulfur oxygenated L-methionine A protein modification that effectively adds oxygen atoms to a sulfur atom of L-methionine residue without removing hydrogen atoms. 18688235 PubMed PSI-MOD-slim SOxyMet PSI-MOD-label Origin M Source artifact TermSpec none MOD:00680 MOD:00913 PSI-MOD MOD:00710 protonated-dimethylated residue A protein modification that effectively adds a proton and replaces two hydrogen atoms with two methyl groups. 18688235 PubMed For N-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts for both protonation and dimethylation. The alternative Me2Res process accounts only for dimethylation and not protonation. PSI-MOD-slim Me2+Res PSI-MOD-label MOD:00429 PSI-MOD MOD:00711 trimethylated protonated-residue A protein modification that effectively replaces three hydrogen atoms with three methyl groups, after a proton has been added to form an aminium group. 18688235 PubMed For amino acids residues, amine trimethylation can effectively only be accomplished with a protonated primary amino group. This process accounts for both protonation and trimethylation. The alternative Me3Res process accounts only for trimethylation and not protonation. PSI-MOD-slim Me3+Res PSI-MOD-label DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 S 0 DiffMono 43.054227 FormalCharge 1+ Formula none MassAvg none MassMono none Origin X Source natural TermSpec N-term MOD:00430 PSI-MOD MOD:00712 methylated proline A protein modification that effectively converts an L-proline residue to a methylated proline, such as N,N-dimethylproline. 18688235 PubMed PSI-MOD-slim MePro PSI-MOD-label Origin P Source natural TermSpec none MOD:00427 MOD:00915 PSI-MOD MOD:00713 methylated glutamic acid A protein modification that effectively converts an L-glutamic acid residue to a methylated glutamic acid, such as L-glutamate 5-methyl ester. 18688235 PubMed PSI-MOD-slim MeGlu PSI-MOD-label Origin X Source natural TermSpec none MOD:00427 MOD:00906 PSI-MOD MOD:00714 methylated glycine A protein modification that effectively converts a glycine residue to a methylated glycine, such as N-methylglycine. 18688235 PubMed MeGly PSI-MOD-label Origin G Source natural TermSpec none MOD:00427 MOD:00908 PSI-MOD MOD:00715 methylated isoleucine A protein modification that effectively converts an L-isoleucine residue to a methylated isoleucine residue, such as N-methyl-L-isoleucine. 18688235 PubMed MeIle PSI-MOD-label Origin I Source natural TermSpec none MOD:00427 MOD:00910 PSI-MOD MOD:00716 methylated methionine A protein modification that effectively converts an L-methionine residue to a methylated methionine, such as N-methyl-L-methionine. 18688235 PubMed PSI-MOD-slim MeMet PSI-MOD-label Origin M Source natural TermSpec N-term MOD:00427 MOD:00913 PSI-MOD MOD:00717 methylated phenylalanine A protein modification that effectively converts an L-phenylalanine residue to a methylated phenylalanine, such as N-methyl-L-phenylalanine. 18688235 PubMed PSI-MOD-slim MePhe PSI-MOD-label Origin F Source natural TermSpec none MOD:00427 MOD:00914 PSI-MOD MOD:00718 methylated tyrosine A protein modification that effectively converts an L-tyrosine residue to a methylated tyrosine, such as N-methyl-L-tyrosine. 18688235 PubMed MeTyr PSI-MOD-label Origin Y Source natural TermSpec N-term MOD:00427 MOD:00919 PSI-MOD MOD:00719 L-methionine sulfoxide A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues. 177 DeltaMass 21406390 PubMed 22116028 PubMed AA0581 RESID 35#M UniMod From DeltaMass: Average Mass: 147 Formula:C5H9O1N2S Monoisotopic Mass Change:147.035 Average Mass Change:147.195 (formula incorrect, N and O reversed) References:PE Sciex. PSI-MOD-slim (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid RESID-systematic L-methionine (R)-S-oxide RESID-alternate L-methionine (R)-sulfoxide RESID-name L-methionine S-oxide PSI-MOD-alternate L-methionine sulfoxide PSI-MOD-alternate Methionyl Sulfoxide DeltaMass-label MetO PSI-MOD-label MOD_RES Methionine (R)-sulfoxide UniProt-feature Oxidation PSI-MS-label oxym OMSSA-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 S 0 DiffMono 15.994915 Formula C 5 H 9 N 1 O 2 S 1 MassAvg 147.19 MassMono 147.035400 Origin M Source artifact TermSpec none MOD:00709 MOD:01854 PSI-MOD MOD:00720 L-methionine (R)-sulfoxide A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide R-diastereomer. 45764 ChEBI 21406390 PubMed 22116028 PubMed 23911929 PubMed AA0581 RESID (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid RESID-systematic L-methionine (R)-S-oxide RESID-alternate L-methionine (R)-sulfoxide RESID-name MOD_RES Methionine (R)-sulfoxide UniProt-feature R-MetO PSI-MOD-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 S 0 DiffMono 15.994915 Formula C 5 H 9 N 1 O 2 S 1 MassAvg 147.19 MassMono 147.035400 Origin M Source natural TermSpec none MOD:00719 PSI-MOD MOD:00721 L-methionine (S)-sulfoxide A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide S-diastereomer. 18688235 PubMed S-MetO PSI-MOD-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 S 0 DiffMono 15.994915 Formula C 5 H 9 N 1 O 2 S 1 MassAvg 147.19 MassMono 147.035400 Origin M Source artifact TermSpec none MOD:00719 PSI-MOD MOD:00722 monomethylated L-glutamine A protein modification that effectively replaces one hydrogen atom of an L-glutamine residue with one methyl group. 34#Q UniMod PSI-MOD-slim Me1Gln PSI-MOD-label methylq OMSSA-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 6 H 10 N 2 O 2 MassAvg 142.16 MassMono 142.074228 Origin Q Source natural TermSpec none MOD:00599 MOD:00659 PSI-MOD MOD:00723 N-acetylated L-lysine A protein modification that effectively converts an L-lysine residue to either N2-acetyl-L-lysine, or N6-acetyl-L-lysine. 18688235 PubMed PSI-MOD-slim NAcLys PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 15 N 2 O 2 MassAvg 171.22 MassMono 171.113353 Origin K Source natural TermSpec none MOD:00408 MOD:00912 PSI-MOD MOD:00724 N-methylated L-histidine A protein modification that effectively replaces one hydrogen atom on a nitrogen of an L-histidine residue with one methyl group. 34#H UniMod PSI-MOD-slim Methyl PSI-MS-label methylh OMSSA-label NMeHis PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 9 N 3 O 1 MassAvg 151.17 MassMono 151.074562 Origin H Source natural TermSpec none MOD:00599 MOD:00602 MOD:00661 PSI-MOD MOD:00725 complex glycosylation A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group linked through a glycosidic bond. 18688235 PubMed MOD:00693 PSI-MOD MOD:00726 glucosylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a glucose group through a glycosidic bond. 18688235 PubMed Glc PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 O 5 DiffMono 162.052823 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00727 mannosylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a mannose group through a glycosidic bond, 18688235 PubMed Man PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 O 5 DiffMono 162.052823 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00728 galactosylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a galactose group through a glycosidic bond. 18688235 PubMed Gal PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 O 5 DiffMono 162.052823 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00729 pentosylated residue a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a pentose sugar group through a glycosidic bond 172 DeltaMass for Pentoses DeltaMass gives mass 132, for Pentosyl DeltaMass gives formula C 6 H 10 N4 with mass 146 Pent PSI-MOD-label Pentoses (Ara, Rib, Xyl) DeltaMass-label Pentosyl DeltaMass-label DiffAvg 132.12 DiffFormula C 5 H 8 O 4 DiffMono 132.042259 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00730 arabinosylated a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a arabinose sugar group through a glycosidic bond 18688235 PubMed Ara PSI-MOD-label DiffAvg 132.12 DiffFormula C 5 H 8 O 4 DiffMono 132.042259 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00729 PSI-MOD MOD:00731 ribosylated a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a ribose sugar group through a glycosidic bond 18688235 PubMed Rib PSI-MOD-label DiffAvg 132.12 DiffFormula C 5 H 8 O 4 DiffMono 132.042259 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00729 PSI-MOD MOD:00732 xylosylated a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a xylose sugar group through a glycosidic bond 18688235 PubMed Xyl PSI-MOD-label DiffAvg 132.12 DiffFormula C 5 H 8 O 4 DiffMono 132.042259 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00729 PSI-MOD MOD:00733 N-acetylaminoglucosylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylglucosamine group through a glycosidic bond. 18688235 PubMed GlcNAc PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00436 PSI-MOD MOD:00734 N-acetylaminogalactosylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylgalactosamine group through a glycosidic bond. 247 DeltaMass From DeltaMass: Average Mass: 203 Formula:C8H13O5N1 Monoisotopic Mass Change:203.079 Average Mass Change:203.196 References:PE Sciex GalNAc PSI-MOD-label N-acetylhexosamines (GalNAc, GlcNAc) DeltaMass-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00436 PSI-MOD MOD:00735 hexosuronylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosuronic acid group through a glycosidic bond. 18688235 PubMed HexA PSI-MOD-label DiffAvg 176.12 DiffFormula C 6 H 8 O 6 DiffMono 176.032088 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00736 deoxyhexosylated a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a deoxyhexose group through a glycosidic bond 0 DeltaMass From DeltaMass: Average Mass: 146 PSI-MOD-slim Deoxyhexoses (Fuc, Rha) DeltaMass-label dHex PSI-MOD-label DiffAvg 146.14 DiffFormula C 6 H 10 O 4 DiffMono 146.057909 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00737 N-acetylneuraminylated A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond. 0 DeltaMass From DeltaMass: Average Mass: 291 N-acetylneuraminic acid (Sialic acid, NeuAc, NANA, SA) DeltaMass-label NeuNAc PSI-MOD-label DiffAvg 291.26 DiffFormula C 11 H 17 N 1 O 8 DiffMono 291.095417 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00738 iron containing modified residue A protein modification that effectively substitutes an iron atom or a cluster containing iron for hydrogen atoms, or that coordinates an iron ion. 18688235 PubMed FeRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00739 iron-sulfur cluster containing modification A protein modification that effectively substitutes a cluster of iron and sulfur atoms for hydrogen atoms. 18688235 PubMed FeSRes PSI-MOD-label MOD:00738 MOD:00860 PSI-MOD MOD:00740 manganese containing modified residue A protein modification that effectively substitutes a manganese atom or a cluster containing manganese for hydrogen atoms, or that coordinates a manganese ion. 18688235 PubMed MnRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00741 nickel containing modified residue A protein modification that effectively substitutes a nickel atom or a cluster containing nickel for hydrogen atoms, or that coordinates a nickel ion. 18688235 PubMed NiRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00742 copper containing modified residue A protein modification that effectively substitutes a copper atom or a cluster containing copper for hydrogen atoms, or that coordinates a copper ion. 18688235 PubMed CuRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00743 molybdenum containing modified residue A protein modification that effectively substitutes a molybdenum atom or a cluster containing molybdenum for hydrogen atoms, or that coordinates a molybdenum ion. 18688235 PubMed PSI-MOD-slim MoRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00744 molybdenum pterin containing modification A protein modification containing a molybdenum atom in a pterin ring system. 18688235 PubMed PSI-MOD-slim MoPterRes PSI-MOD-label MOD:00743 MOD:00748 PSI-MOD MOD:00745 selenium containing residue A protein modification that effectively substitutes a selenium atom or a cluster containing selenium for hydrogen atoms. 18688235 PubMed PSI-MOD-slim SeRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00746 tungsten containing modified residue A protein modification that effectively substitutes a tungsten atom or a cluster containing tungsten for hydrogen atoms, or that coordinates a tungsten ion. 18688235 PubMed WRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00747 sodium containing modified residue A protein modification that effectively substitutes a sodium atom for a hydrogen atom. 18688235 PubMed PSI-MOD-slim NaRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00748 pterin modified residue A protein modification that effectively results from forming an adduct with a compound containing a pterin group. 18688235 PubMed PSI-MOD-slim PterRes PSI-MOD-label MOD:01156 PSI-MOD MOD:00749 sulfur substitution for oxygen A protein modification that effectively substitutes a sulfur atom for an oxygen atom. 18688235 PubMed PSI-MOD-slim S(O)Res PSI-MOD-label MOD:00860 PSI-MOD MOD:00750 deoxyribonucleic acid linked residue A protein modification that effectively crosslinks an amino acid residue and the 3'- or 5'-end of DNA through a phosphodiester bond. 18688235 PubMed DNARes PSI-MOD-label MOD:00701 PSI-MOD MOD:00751 ribonucleic acid linked residue a protein modification 18688235 PubMed RNARes PSI-MOD-label MOD:00701 PSI-MOD MOD:00752 adenosine diphosphoribosyl (ADP-ribosyl) modified residue A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond. 0 DeltaMass From DeltaMass: Average Mass: 541. PSI-MOD-slim ADP-rybosylation (from NAD) DeltaMass-label ADPRibRes PSI-MOD-label DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00701 PSI-MOD MOD:00753 chlorinated residue A protein modification that effectively substitutes a chlorine atom for a hydrogen atom. 18688235 PubMed ClRes PSI-MOD-label Origin X Source none TermSpec none MOD:00694 PSI-MOD MOD:00754 brominated residue A protein modification that effectively substitutes a bromine atom for a hydrogen atom. 18688235 PubMed BrRes PSI-MOD-label Origin X Source none TermSpec none MOD:00694 PSI-MOD MOD:00755 iodinated residue A protein modification that effectively substitutes an iodine atom of a residue for a hydrogen atom. 18688235 PubMed PSI-MOD-slim IRes PSI-MOD-label Origin X Source none TermSpec none MOD:00694 PSI-MOD MOD:00756 4-hydroxy-D-valine A protein modification that effectively converts an L-valine residue to 4-hydroxy-D-valine. 15853325 PubMed AA0388 RESID (2R,3Xi)-2-amino-4-hydroxy-3-methylbutanoic acid RESID-systematic 4-hydroxy-D-valine RESID-name D-4HyVal PSI-MOD-label D-gamma-hydroxyvaline RESID-alternate MOD_RES D-4-hydroxyvaline UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 9 N 1 O 2 MassAvg 115.13 MassMono 115.063329 Origin V Source natural TermSpec none MOD:00425 MOD:00664 PSI-MOD MOD:00757 O4-galactosyl-L-hydroxyproline A protein modification that effectively converts an L-proline residue to O4-galactosyl-L-hydroxyproline. AA0389 RESID secondary to RESID:AA0030 (2S,4R)-4-(beta-D-galactopyranosyloxy)pyrrolidine-2-carboxylic acid RESID-systematic 4-(beta-D-galactopyranosyloxy)proline RESID-alternate 4-(galactosyloxy)proline RESID-alternate beta-galactopyranosyl-4-hydroxyproline RESID-alternate O4-galactosyl-L-hydroxyproline RESID-name O4-glycosyl-hydroxyproline RESID-alternate DiffAvg 178.14 DiffFormula C 6 H 10 N 0 O 6 DiffMono 178.047738 Formula C 11 H 17 N 1 O 7 MassAvg 275.26 MassMono 275.100502 Origin P Source natural TermSpec none MOD:00915 PSI-MOD MOD:00758 O4-(N-acetylamino)glucosyl-L-hydroxyproline A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)glucosyl-L-hydroxyproline. 15238247 PubMed 9660787 PubMed AA0390 RESID secondary to RESID:AA0030 (2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-glucopyranosyloxy]pyrrolidine-2-carboxylic acid RESID-systematic 4-(N-acetylglucosaminyloxy)proline RESID-alternate 4-[(2-N-acetylamino)-alpha-D-glucopyranosyl]oxyproline RESID-alternate alpha-2-(N-acetylamino)glucopyranosyl-4-hydroxyproline RESID-alternate HexNAc PSI-MS-label O4-(N-acetylamino)glucosyl-L-hydroxyproline RESID-name O4-glycosyl-hydroxyproline RESID-alternate O4GlcNAcHyPro PSI-MOD-label DiffAvg 219.19 DiffFormula C 8 H 13 N 1 O 6 DiffMono 219.074287 Formula C 13 H 20 N 2 O 7 MassAvg 316.31 MassMono 316.127051 Origin P Source natural TermSpec none MOD:00448 MOD:01677 PSI-MOD MOD:00759 fucosylated biantennary (-1 galactose) modification from UniMod N-linked glycosylation 307 UniMod dHex(1)Hex(4)HexNAc(4) PSI-MS-label Fucosylated biantennary (-1 galactose) UniMod-description DiffAvg 1607.48 DiffFormula C 62 H 102 N 4 O 44 DiffMono 1606.586693 Formula C 66 H 108 N 6 O 46 MassAvg 1721.59 MassMono 1720.629620 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00760 biantennary modification from UniMod N-linked glycosylation - missing ref 311 UniMod Biantennary UniMod-description Hex(5)HexNAc(4) PSI-MS-label DiffAvg 1623.48 DiffFormula C 62 H 102 N 4 O 45 DiffMono 1622.581607 Formula C 66 H 108 N 6 O 47 MassAvg 1737.59 MassMono 1736.624535 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00761 monohexosylated (Hex1) A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with one hexose sugar group through a glycosidic bond. 18688235 PubMed Hex1 PSI-MOD-alternate DiffAvg 162.14 DiffFormula C 6 H 10 O 5 DiffMono 162.052823 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00434 PSI-MOD MOD:00762 biantennary (-2 galactose) modification from UniMod N-linked glycosylation - missing ref 309 UniMod Biantennary (-2 galactose) UniMod-description Hex(3)HexNAc(4) PSI-MS-label DiffAvg 1299.20 DiffFormula C 50 H 82 N 4 O 35 DiffMono 1298.475960 Formula C 54 H 88 N 6 O 37 MassAvg 1413.30 MassMono 1412.518888 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00763 biantennary (-1 galactose) modification from UniMod N-linked glycosylation - missing ref 310 UniMod Biantennary (-1 galactose) UniMod-description Hex(4)HexNAc(4) PSI-MS-label DiffAvg 1461.34 DiffFormula C 56 H 92 N 4 O 40 DiffMono 1460.528784 Formula C 60 H 98 N 6 O 42 MassAvg 1575.44 MassMono 1574.571711 Origin N Source natural TermSpec none MOD:00725 MOD:00903 PSI-MOD MOD:00764 glycoconjugated residue A protein modification that effectively results from forming an adduct with a carbohydrate-like group either through enzymatic formation of a glycosidic bond, or through non-enzymatic glycation formation of a Schiff-base or an Amadori ketosamine residue adduct. 18688235 PubMed 3743566 PubMed PSI-MOD-slim MOD:01156 PSI-MOD MOD:00765 cysteinylation (disulfide with free L-cysteine) A protein modification that effectively converts an L-cysteine residue to S-(L-cysteinyl)-L-cysteine, forming a disulfide bond with free cysteine. 260 DeltaMass 1988019 PubMed 2001356 PubMed 2076469 PubMed 3083866 PubMed 366603 PubMed 7918467 PubMed 8344916 PubMed AA0025#CYS1 RESID 312 UniMod This entry is for formation of a disulfide bond between a peptide cysteine and a free cysteine. For the cystine cross-link, see MOD:00234. From DeltaMass: (name misspelled and formula incorrect, N and O reversed) Formula: C6H10O2N3S2 Monoisotopic Mass Change: 222.013 Average Mass Change: 222.283 PSI-MOD-slim (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) RESID-systematic 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid RESID-misnomer 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) RESID-alternate 3,3'-dithiobis(2-aminopropanoic acid) RESID-alternate 3,3'-dithiobisalanine RESID-alternate 3,3'-dithiodialanine RESID-alternate beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide RESID-alternate beta,beta'-dithiodialanine RESID-alternate bis(alpha-aminopropionic acid)-beta-disulfide RESID-alternate bis(beta-amino-beta-carboxyethyl)disulfide RESID-alternate Cysteinylation DeltaMass-label dicysteine RESID-alternate L-cystine RESID-name MOD_RES S-cysteinyl cysteine UniProt-feature S-cystenyl cystenyl DeltaMass-label SCysCys PSI-MOD-label DiffAvg 119.14 DiffFormula C 3 H 5 N 1 O 2 S 1 DiffMono 119.004099 Formula C 6 H 10 N 2 O 3 S 2 MassAvg 222.28 MassMono 222.013284 Origin C Source natural TermSpec none MOD:00905 MOD:01862 PSI-MOD MOD:00766 C terminal -K from HC of MAb modification from UniMod Post-translational - C-terminal loss of lysine 16078144 PubMed 313 UniMod Loss of C-terminal K from Heavy Chain of MAb UniMod-description Lys-loss PSI-MS-label DiffAvg -128.18 DiffFormula C -6 H -12 N -2 O -1 DiffMono -128.094963 Formula none MassAvg none MassMono none Origin X TermSpec C-term MOD:00003 PSI-MOD MOD:00767 glycated residue A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein amino group to form a Schiff-base or an Amadori ketosamine residue adduct. 18688235 PubMed Source artifact MOD:00764 PSI-MOD MOD:00768 methionine oxidation with neutral loss of 80 Da Oxidation of methionine to methionine sulfone with neutral loss of CH3SO2H. 18688235 PubMed 9004526 PubMed Originally created from UniMod:508 that was later deleted. DiffAvg -80.10 DiffFormula C -1 H -4 N 0 O -2 S -1 DiffMono -79.993200 Formula C 4 H 5 N 1 O 1 S 0 MassAvg 83.09 MassMono 83.037114 Origin M Source artifact TermSpec none MOD:00431 PSI-MOD MOD:00769 residues isobaric at 71.0-71.1 Da Natural or modified residues with a mass of 71.0-71.1 Da. 18688235 PubMed PSI-MOD-slim MOD:00616 PSI-MOD MOD:00770 residues isobaric at a resolution below 0.01 Da Natural or modified residues that are isobaric at a resolution below 0.01 Da. 18688235 PubMed PSI-MOD-slim MOD:00616 PSI-MOD MOD:00771 residues isobaric at 166.98-167.00 Da Natural or modified residues with a mass of 166.98-167.00 Da. 18688235 PubMed PSI-MOD-slim MOD:00770 PSI-MOD MOD:00772 vanadium containing modified residue A protein modification that effectively substitutes a vanadium atom or a cluster containing vanadium for hydrogen atoms, or that coordinates a vanadium ion. 18688235 PubMed VRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00773 residues isobaric at 181.00-181.02 Da Natural or modified residues with a mass of 181.00-181.02 Da. 18688235 PubMed PSI-MOD-slim MOD:00770 PSI-MOD MOD:00774 residues isobaric at 243.02-243.03 Da Natural or modified residues with a mass of 243.02-243.03 Da. 18688235 PubMed PSI-MOD-slim MOD:00770 PSI-MOD MOD:00775 L-asparagine (His) An artifactual protein modification that converts an L-histidine residue to L-asparagine by oxidative degradation. 9252331 PubMed 348 UniMod His->Asn PSI-MS-label his2asnh OMSSA-label histidine oxidation to aspargine UniMod-description DiffAvg -23.04 DiffFormula C -2 H -1 N -1 O 1 DiffMono -23.015984 Formula C 4 H 6 N 2 O 2 MassAvg 114.10 MassMono 114.042927 Origin H Source artifact TermSpec none MOD:00012 MOD:00909 PSI-MOD MOD:00776 L-aspartic acid (His) An artifactual protein modification that converts an L-histidine residue to L-aspartic acid by oxidative degradation. 9252331 PubMed 349 UniMod From OMSSA: desc="oxidation of H to D" monomass= -23.015984 (this is the same mass difference as OMSSA:54, his2asnh) [JSG]. His->Asp PSI-MS-label his2asph OMSSA-label histidine oxidation to aspartic acid UniMod-description DiffAvg -22.05 DiffFormula C -2 H -2 N -2 O 2 DiffMono -22.031969 Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin H Source artifact TermSpec none MOD:00013 MOD:00909 PSI-MOD MOD:00777 residues isobaric at 182.96-182.98 Da Natural or modified residues with a mass of 182.96-182.98 Da. 18688235 PubMed MOD:00770 MOD:00778 PSI-MOD MOD:00778 residues isobaric at 182.9-183.0 Da Natural or modified residues with a mass of 182.9-183.0 Da. 18688235 PubMed PSI-MOD-slim MOD:00616 PSI-MOD MOD:00779 lysine oxidation to aminoadipic semialdehyde OBSOLETE because redundant with MOD:00130. Remap to MOD:00130. 352 DeltaMass 11332453 PubMed 358196 PubMed 5337886 PubMed 5529814 PubMed 352 UniMod From DeltaMass: Average Mass: -1 Average Mass Change:-1 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Oxidation of lysine (to aminoadipic semialdehyde) DeltaMass-label DiffAvg -1.03 DiffFormula H -3 N -1 O 1 DiffMono -1.031634 Formula none MassAvg none MassMono none Origin K Source natural TermSpec none 1 PSI-MOD MOD:00780 N-acetyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N-acetyl-L-asparagine. 18688235 PubMed This modification has not been observed to occur naturally. AcAsn PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 6 H 8 N 2 O 3 MassAvg 156.14 MassMono 156.053492 Origin N Source artifact TermSpec N-term MOD:00903 MOD:01458 PSI-MOD MOD:00781 N2-acetyl-L-histidine A protein modification that effectively converts an L-histidine residue to N2-acetyl-L-histidine. 18688235 PubMed This modification has not been observed to occur naturally. AcHis PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 9 N 3 O 2 MassAvg 179.18 MassMono 179.069477 Origin H Source artifact TermSpec N-term MOD:00909 MOD:01458 PSI-MOD MOD:00782 N-acetyl-L-leucine A protein modification that effectively converts an L-leucine residue to N-acetyl-L-leucine. 18688235 PubMed This modification has not been observed to occur naturally. AcLeu PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 8 H 14 N 1 O 2 MassAvg 156.20 MassMono 156.102454 Origin L Source artifact TermSpec N-term MOD:00911 MOD:01458 PSI-MOD MOD:00783 dimethylated L-arginine A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two methyl groups. 36#R UniMod PSI-MOD-slim Dimethyl PSI-MS-label dimethylr OMSSA-label NNMe2Arg PSI-MOD-label DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 16 N 4 O 1 MassAvg 184.24 MassMono 184.132411 Origin R Source natural TermSpec none MOD:00429 MOD:00658 PSI-MOD MOD:00784 N-acetyl-L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to N-acetyl-L-phenylalanine. 18688235 PubMed This modification has not been observed to occur naturally. AcPhe PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 11 H 11 N 1 O 2 MassAvg 189.21 MassMono 189.078979 Origin F Source artifact TermSpec N-term MOD:00914 MOD:01458 PSI-MOD MOD:00785 N2-acetyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to N2-acetyl-L-tryptophan. 18688235 PubMed This modification has not been observed to occur naturally. AcTrp PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 13 H 12 N 2 O 2 MassAvg 228.25 MassMono 228.089878 Origin W Source artifact TermSpec N-term MOD:00918 MOD:01458 PSI-MOD MOD:00786 deuterium substituted residue A protein modification that effectively substitutes one or more (2)H deuterium atoms for (1)H protium atoms. 18688235 PubMed PSI-MOD-slim D(H)Res PSI-MOD-label MOD:00839 PSI-MOD MOD:00787 diisopropylphosphoserine modification from UniMod - label for the active site serine of the serine esterase/protease family also shown to label tyrosine in serum albumin 362 UniMod Diisopropylphosphate UniMod-interim O-Diisopropylphosphorylation UniMod-description DiffAvg 164.14 DiffFormula C 6 H 13 O 3 P 1 DiffMono 164.060231 Formula C 9 H 18 N 1 O 5 P 1 MassAvg 251.22 MassMono 251.092259 Origin S Source artifact TermSpec none MOD:00848 MOD:00861 MOD:00916 PSI-MOD MOD:00788 isopropylphosphotyrosine modification from UniMod 363 UniMod Isopropylphospho UniMod-interim O-Isopropylphosphorylation UniMod-description DiffAvg 122.06 DiffFormula C 3 H 7 O 3 P 1 DiffMono 122.013281 Formula C 12 H 16 N 1 O 5 P 1 MassAvg 285.24 MassMono 285.076609 Origin Y Source artifact TermSpec none MOD:00848 MOD:00861 MOD:00919 PSI-MOD MOD:00789 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied. 15602776 PubMed 364 UniMod Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form UniMod-description ICPL:13C(6) PSI-MS-label DiffAvg 111.04 DiffFormula (13)C 6 H 3 N 1 O 1 DiffMono 111.041593 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00790 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied. 15602776 PubMed 365 UniMod Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form UniMod-description ICPL PSI-MS-label DiffAvg 105.02 DiffFormula (12)C 6 H 3 N 1 O 1 DiffMono 105.021464 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 PSI-MOD MOD:00791 1x(18)O labeled deamidated L-glutamine A protein modification that effectively converts an L-glutamine residue to L-glutamic acid with one (18)O. 8382902 PubMed 366#Q UniMod PSI-MOD-slim Deamidated:18O(1) PSI-MS-label Deamidation in presence of O18 UniMod-description DiffAvg 2.99 DiffFormula H -1 N -1 (18)O 1 DiffMono 2.988262 Formula C 5 H 7 N 1 (16)O 2 (18)O 1 MassAvg 131.05 MassMono 131.046839 Origin Q Source artifact TermSpec none MOD:00685 MOD:00852 PSI-MOD MOD:00792 deuterium monosubstituted residue A protein modification that effectively substitutes one (2)H deuterium atom for one (1)H protium atom. 18688235 PubMed PSI-MOD-slim D(H)1Res PSI-MOD-label MOD:00786 PSI-MOD MOD:00793 dehydroalanine (Cys) A protein modification that effectively converts an L-cysteine residue to dehydroalanine. 17123 ChEBI 8 DeltaMass 10220322 PubMed 11212008 PubMed 1547888 PubMed 15799070 PubMed 1815586 PubMed 20805503 PubMed 2914619 PubMed 7947813 PubMed 8239649 PubMed AA0181#CYS RESID 368 UniMod From DeltaMass: In an attempt to clarfiy the difference between the modification of cysteine to lanthionine and cysteine to dehydroalanine, the following contributions from the ABRF email forum are presented:Structurally speaking lanthionine is like cystine but lacks one S atom. I imagine one can think of it as a condensation of cysteine and dehydroalanine but I do not know how it is made biologically. Dehydroalanine could be derived from either serine or cysteine. If I recall Biochem 101 correctly lanthionine was first found in wool.-Lowell Ericsson (ERICSSONLH@U.WASHINGTON.EDU)As far as I know, the structure of lanthionine is two Ala's joined by a single sulphur with the loss of two hydrogens from the methyl group of the Ala.Stephen Bayne (sbay@novo.dk)Regarding the structure of lanthionine and dehydroalanine: dehydroalanine is formed by the loss of one sulfur atom and two hydrogen atoms from ONE cysteine residue. lanthionine is formed from TWO cysteines, is a thioether, and contains one sulfur atom less than the amino acid cystine. Dan McCormick (MCCORMICK@rcf.mayo.edu) [DeltaMass]. Most bacterially produced lanthionine crosslinks are made by dehydration of L-serine to dehydroalanine, and then reaction with L-cysteine so as to produce chiral inversion at the alpha-carbon of the original L-serine; the lanthionine is a meso-diastereomer with L-configuration of the original cysteine alpha-carbon and D-configuration of the original L-serine alpha-carbon. In cypemycin dehydroalanine has been shown to be produced by loss of hydrogen sulfide from cysteine. Beta-elimination of hydrogen sulfide does occur during treatment with performic acid [JSG]. PSI-MOD-slim 2,3-didehydroalanine RESID-alternate 2-aminoacrylic acid RESID-alternate 2-aminopropenoic acid RESID-systematic 4-methylidene-imidazole-5-one (MIO) active site RESID-alternate anhydroserine RESID-alternate Cys->Dha PSI-MS-label dehydroalanine RESID-name Dehydroalanine (from Cysteine) DeltaMass-label Dehydroalanine (from Cysteine) UniMod-description Dha RESID-alternate dHAla(Cys) PSI-MOD-label MOD_RES 2,3-didehydroalanine (Cys) UniProt-feature DiffAvg -34.08 DiffFormula C 0 H -2 N 0 O 0 S -1 DiffMono -33.987721 Formula C 3 H 3 N 1 O 1 MassAvg 69.06 MassMono 69.021464 Origin C Source natural TermSpec none MOD:00905 MOD:01168 PSI-MOD MOD:00794 pyrrolidone from proline OBSOLETE because redundant and identical to MOD:00477. Remap to MOD:00477. 9252331 PubMed 369 UniMod This UniMod entry appears to have come from the same description in PubMed:9252331 as UniMod:360. This entry was not annotated as being approved. Neither difference formula corresponds to the result described in the original citation PubMed:2161657. Pro->Pyrrolidone UniMod-interim Pyrrolidone from Proline UniMod-description DiffAvg -28.01 DiffFormula C -1 O -1 DiffMono -27.994915 Formula C 4 H 7 N 1 O 0 MassAvg 69.11 MassMono 69.057849 Origin P Source artifact TermSpec none 1 PSI-MOD MOD:00795 Michael addition of hydroxymethylvinyl ketone to cysteine modification from UniMod 11743741 PubMed 371 UniMod HMVK PSI-MS-label Michael addition of hydroxymethylvinyl ketone to cysteine UniMod-description DiffAvg 86.09 DiffFormula C 4 H 6 O 2 DiffMono 86.036779 Formula C 7 H 11 N 1 O 3 S 1 MassAvg 189.23 MassMono 189.045964 Origin C Source artifact TermSpec none MOD:00905 PSI-MOD MOD:00796 L-ornithine (Arg) A protein modification that effectively converts an L-arginine residue to L-ornithine. 129 DeltaMass 15489230 PubMed 372 UniMod PSI-MOD-slim Arg->Orn PSI-MS-label arg2orn OMSSA-label Ornithine (from Arginine) DeltaMass-label Ornithine from Arginine UniMod-description Ornithyl DeltaMass-label DiffAvg -42.04 DiffFormula C -1 H -2 N -2 DiffMono -42.021798 Formula C 5 H 10 N 2 O 1 MassAvg 114.15 MassMono 114.079313 Origin R Source artifact TermSpec none MOD:00902 PSI-MOD MOD:00797 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal a protein modification that effectively converts an L-cysteine residue to the PEP adduct, 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal 4696757 PubMed 7999765 PubMed 8664284 PubMed AA0391 RESID (2R)-2-amino-3-[1-carboxy-1-(phosphonooxy)ethyl]sulfanylpropanoic acid RESID-systematic 2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid RESID-alternate 2-([(2R)-2-azanyl-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid RESID-alternate 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal RESID-name cysteinyl pyruvate O-phosphothioketal RESID-alternate MOD_RES 2-(S-cysteinyl)pyruvic acid O-phosphothioketal UniProt-feature phosphoenolpyruvate cysteine adduct RESID-alternate phospholactoyl cysteine adduct RESID-alternate S-[1-carboxy-1-(phosphonooxy)ethyl]cysteine RESID-alternate SPEPCys PSI-MOD-label DiffAvg 168.04 DiffFormula C 3 H 5 N 0 O 6 P 1 S 0 DiffMono 167.982375 Formula C 6 H 10 N 1 O 7 P 1 S 1 MassAvg 271.18 MassMono 270.991559 Origin C Source natural TermSpec none MOD:00861 MOD:00905 PSI-MOD MOD:00798 half cystine A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed. 1988019 PubMed 2001356 PubMed 2076469 PubMed 3083866 PubMed 366603 PubMed 7918467 PubMed 8344916 PubMed 374 UniMod Dehydro PSI-MS-label Half of a disulfide bridge UniMod-description DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 S 0 DiffMono -1.007825 Formula C 3 H 4 N 1 O 1 S 1 MassAvg 102.13 MassMono 102.001360 Origin C Source none TermSpec none MOD:00905 PSI-MOD MOD:00799 S-galactosyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-galactosyl-L-cysteine. 11945907 PubMed AA0392 RESID The reported peptide has not been isolated or characterized in subsequent work, and the peptide sequence has not been found in the human proteome. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. (2R)-2-amino-3-(D-galactopyranosylsulfanyl)propanoic acid RESID-systematic S-(beta-D-galactopyranosyl)cysteine RESID-alternate S-galactosyl-L-cysteine RESID-name S-glycosyl-cysteine RESID-alternate SGalCys PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 S 0 DiffMono 162.052823 Formula C 9 H 15 N 1 O 6 S 1 MassAvg 265.28 MassMono 265.062008 Origin C Source artifact TermSpec none MOD:00426 MOD:00476 MOD:00761 MOD:00905 PSI-MOD MOD:00800 L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-vanadium seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide. 2345152 PubMed AA0393 RESID Cross-link 2; incidental to RESID:AA0300. CysHis-[V7Fe9S] PSI-MOD-label L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide carbide RESID-name nitrogenase iron-vanadium cofactor RESID-alternate DiffAvg 932.51 DiffFormula C 7 Fe 7 H 6 N 0 O 7 S 9 V 1 DiffMono 932.248513 Formula C 16 Fe 7 H 18 N 4 O 9 S 10 V 1 MassAvg 1172.80 MassMono 1172.316610 Origin C, H Source hypothetical TermSpec none MOD:00739 MOD:00772 MOD:00905 MOD:00909 PSI-MOD MOD:00801 L-cysteinyl-L-histidino-homocitryl octairon nonasulfide A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and an eight-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl octairon nonasulfide. 8392330 PubMed AA0394 RESID Cross-link 2; incidental to RESID:AA0300. CysHis-[8Fe9S] PSI-MOD-label L-cysteinyl-L-histidino-homocitryl octairon nonasulfide carbide RESID-name nitrogenase iron-iron cofactor RESID-alternate DiffAvg 937.42 DiffFormula C 7 Fe 8 H 6 N 0 O 7 S 9 DiffMono 937.240588 FormalCharge 2- Formula C 16 Fe 8 H 18 N 4 O 9 S 10 MassAvg 1177.70 MassMono 1177.308685 Origin C, H Source hypothetical TermSpec none MOD:00739 MOD:00905 MOD:00909 PSI-MOD MOD:00802 L-histidino vanadium tetraoxide a protein modification that effectively converts an L-histidine residue to L-histidino vanadium tetraoxide 10543953 PubMed 16494433 PubMed 8552646 PubMed AA0395 RESID (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (dihydroxy)dioxovanadium RESID-alternate 1'-vanadato-L-histidine RESID-alternate bromoperoxidase vanadium cofactor RESID-alternate chloroperoxidase vanadium cofactor RESID-alternate dihydrogen (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (tetraoxido)vanadate RESID-systematic haloperoxidase vanadium cofactor RESID-alternate histidine-1-vanadate RESID-alternate histidine-N(epsilon)-vanadate RESID-alternate histidine-N1'-vanadate RESID-alternate L-histidino vanadium tetraoxide RESID-name N(tau)-vanadatohistidine RESID-alternate NtauH2VO4His PSI-MOD-label tele-vanadatohistidine RESID-alternate DiffAvg 116.95 DiffFormula C 0 H 2 N 0 O 4 V 1 DiffMono 116.939268 Formula C 6 H 9 N 3 O 5 V 1 MassAvg 254.10 MassMono 253.998180 Origin H Source natural TermSpec none MOD:00772 MOD:00909 PSI-MOD MOD:00803 3-(S-L-cysteinyl)-L-tyrosine A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine. 15342250 PubMed AA0396 RESID Cross-link 2. (2S,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid RESID-systematic 2-amino-3-(2-amino-2-carboxyethylthio)-3-(4-hydroxyphenyl)propanoic acid RESID-alternate 3-(L-cystein-S-yl)-L-tyrosine RESID-name CROSSLNK 3-(S-cysteinyl)-tyrosine (Cys-Tyr) UniProt-feature S-(tyros-3'-yl)cysteine RESID-alternate XLNKSCys3Tyr PSI-MOD-label DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 12 H 12 N 2 O 3 S 1 MassAvg 264.30 MassMono 264.056863 Origin C, Y Source natural TermSpec none MOD:00919 MOD:01993 PSI-MOD MOD:00804 O-glucosyl-L-serine A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine. 10734111 PubMed 2105311 PubMed 2511201 PubMed AA0397 RESID PSI-MOD-slim (2S)-2-amino-3-(beta-D-glucopyranosyloxy)propanoic acid RESID-systematic CARBOHYD O-linked (Glc) UniProt-feature CARBOHYD O-linked (Hex) UniProt-feature O-glucosyl-L-serine RESID-name O-glycosylserine RESID-alternate O3-glucosylserine RESID-alternate OGlcSer PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 9 H 15 N 1 O 7 MassAvg 249.22 MassMono 249.084852 Origin S Source natural TermSpec none MOD:00002 MOD:00433 MOD:00761 PSI-MOD MOD:00805 O-(N-acetylamino)glucosyl-L-serine A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminoglucosyl)-L-serine. 3086323 PubMed 8404891 PubMed AA0398 RESID PSI-MOD-slim (2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)propanoic acid RESID-systematic CARBOHYD O-linked (GlcNAc) UniProt-feature CARBOHYD O-linked (HexNAc) UniProt-feature HexNAc PSI-MS-label O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-serine RESID-alternate O-(N-acetylamino)glucosyl-L-serine RESID-name O-(N-acetylglucosaminyl)serine RESID-alternate O-glycosylserine RESID-alternate O-seryl-beta-N-acetylglucosaminide RESID-alternate O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-serine RESID-alternate O3-(N-acetylglucosaminyl)serine RESID-alternate OGlcNAcSer PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 11 H 18 N 2 O 7 MassAvg 290.27 MassMono 290.111401 Origin S Source natural TermSpec none MOD:00448 MOD:01675 PSI-MOD MOD:00806 O-(N-acetylamino)glucosyl-L-threonine A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminoglucosyl)-L-threonine. 3086323 PubMed 8404891 PubMed AA0399 RESID PSI-MOD-slim (2S,3R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)butanoic acid RESID-systematic CARBOHYD O-linked (GlcNAc) UniProt-feature CARBOHYD O-linked (HexNAc) UniProt-feature HexNAc PSI-MS-label O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-threonine RESID-alternate O-(N-acetylamino)glucosyl-L-threonine RESID-name O-(N-acetylglucosaminyl)-L-threonine RESID-alternate O-glycosylthreonine RESID-alternate O-threonyl-beta-N-acetylglucosaminide RESID-alternate O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-threonine RESID-alternate O3-(N-acetylglucosaminyl)threonine RESID-alternate OGlcNAcThr PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 12 H 20 N 2 O 7 MassAvg 304.30 MassMono 304.127051 Origin T Source natural TermSpec none MOD:00448 MOD:01676 PSI-MOD MOD:00807 pyruvic acid (Ser) A protein modification that effectively converts an L-serine residue to pyruvic acid. 23 DeltaMass 10085076 PubMed 3042771 PubMed 8464063 PubMed AA0127#SER RESID 385#S UniMod DeltaMass gives mass 70 and difference mass -16 with no formula PSI-MOD-slim 2-oxopropanoic acid RESID-systematic MOD_RES Pyruvic acid (Ser) UniProt-feature Pyruvate DeltaMass-label pyruvic acid RESID-name Pyruvoyl- (Serine) DeltaMass-label DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 3 H 3 O 2 MassAvg 71.06 MassMono 71.013304 Origin S Source natural TermSpec N-term MOD:00916 MOD:01154 MOD:01160 PSI-MOD MOD:00808 O-galactosyl-L-serine A protein modification that effectively converts an L-serine residue to O3-galactosylserine. 666730 PubMed AA0400 RESID (2S)-2-amino-3-(alpha-D-galactopyranosyloxy)propanoic acid RESID-systematic CARBOHYD O-linked (Gal) UniProt-feature CARBOHYD O-linked (Hex) UniProt-feature O-galactosyl-L-serine RESID-name O-glycosylserine RESID-alternate O3-galactosylserine RESID-alternate OGalSer PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 9 H 15 N 1 O 7 MassAvg 249.22 MassMono 249.084852 Origin S Source natural TermSpec none MOD:00002 MOD:00476 MOD:00761 PSI-MOD MOD:00809 O-galactosyl-L-threonine A protein modification that effectively converts an L-threonine residue to O3-galactosylthreonine. 2673008 PubMed AA0401 RESID (2S,3R)-2-amino-3-(alpha-D-galactopyranosyloxy)butanoic acid RESID-systematic CARBOHYD O-linked (Gal) UniProt-feature CARBOHYD O-linked (Hex) UniProt-feature O-galactosyl-L-threonine RESID-name O-glycosylthreonine RESID-alternate O3-galactosylthreonine RESID-alternate OGalThr PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 10 H 17 N 1 O 7 MassAvg 263.25 MassMono 263.100502 Origin T Source natural TermSpec none MOD:00476 MOD:00761 MOD:01348 PSI-MOD MOD:00810 O-mannosyl-L-serine A protein modification that effectively converts an L-serine residue to O3-mannosylserine. 391559 PubMed AA0402 RESID (2S)-2-amino-3-(alpha-D-mannopyranosyloxy)propanoic acid RESID-systematic CARBOHYD O-linked (Hex) UniProt-feature CARBOHYD O-linked (Man) UniProt-feature O-glycosylserine RESID-alternate O-mannopyranosylserine RESID-alternate O-mannosyl-L-serine RESID-name O3-mannosylserine RESID-alternate OManSer PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 9 H 15 N 1 O 7 MassAvg 249.22 MassMono 249.084852 Origin S Source natural TermSpec none MOD:00002 MOD:00595 MOD:00761 PSI-MOD MOD:00811 O-mannosyl-L-threonine a protein modification that effectively forms a O3-mannosylthreonine 391559 PubMed AA0403 RESID (2S,3R)-2-amino-3-(alpha-D-mannopyranosyloxy)butanoic acid RESID-systematic CARBOHYD O-linked (Hex) UniProt-feature CARBOHYD O-linked (Man) UniProt-feature O-glycosylthreonine RESID-alternate O-mannosyl-L-threonine RESID-name O3-mannosylthreonine RESID-alternate OManThr PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 10 H 17 N 1 O 7 MassAvg 263.25 MassMono 263.100502 Origin T Source natural TermSpec none MOD:00595 MOD:00761 MOD:01348 PSI-MOD MOD:00812 O-fucosyl-L-serine A protein modification that effectively converts an L-serine residue to an O-fucosylserine. 10734111 PubMed 11067851 PubMed 11344537 PubMed 12096136 PubMed 1517205 PubMed 15189151 PubMed 1904059 PubMed 3311742 PubMed 3578767 PubMed AA0404 RESID 295#S UniMod PSI-MOD-slim (2S)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)propanoic acid RESID-systematic CARBOHYD O-linked (dHex) UniProt-feature CARBOHYD O-linked (Fuc) UniProt-feature dHex PSI-MS-label Fucose UniMod-description O-fucosyl-L-serine RESID-name O-glycosylserine RESID-alternate O3-fucosylserine RESID-alternate OFucSer PSI-MOD-label DiffAvg 146.14 DiffFormula C 6 H 10 N 0 O 4 DiffMono 146.057909 Formula C 9 H 15 N 1 O 6 MassAvg 233.22 MassMono 233.089937 Origin S Source natural TermSpec none MOD:00002 MOD:00614 PSI-MOD MOD:00813 O-fucosyl-L-threonine A protein modification that effectively converts an threonine residue to an O-fucosylthreonine. 11344537 PubMed 11857757 PubMed 15189151 PubMed 1740125 PubMed 1900431 PubMed AA0405 RESID 295#T UniMod PSI-MOD-slim (2S,3R)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)butanoic acid RESID-systematic CARBOHYD O-linked (dHex) UniProt-feature CARBOHYD O-linked (Fuc) UniProt-feature dHex PSI-MS-label Fucose UniMod-description O-fucosyl-L-threonine RESID-name O-glycosylthreonine RESID-alternate O3-fucosylthreonine RESID-alternate OFucThr PSI-MOD-label DiffAvg 146.14 DiffFormula C 6 H 10 N 0 O 4 DiffMono 146.057909 Formula C 10 H 17 N 1 O 6 MassAvg 247.25 MassMono 247.105587 Origin T Source natural TermSpec none MOD:00005 MOD:00614 PSI-MOD MOD:00814 O-xylosyl-L-serine A protein modification that effectively converts an L-serine residue to O3-xylosylserine. 8747463 PubMed AA0406 RESID One glycosylated serine with weak electron density was modeled as O3-alpha-xylosylserine, while O3-alpha-mannosyl serine and threonine were modeled at ten other positions. The authors do not discuss this exception or provide chemical evidence for it. Since an O3-xylosyl serine modification has not been reported in any other fungal proteins, the modification is probably also an O3-alpha-mannosyl serine, see MOD:00810 [JSG]. (2S)-2-amino-3-(alpha-D-xylopyranosyloxy)propanoic acid RESID-systematic O-(beta-D-xylopyranosyl)-L-serine RESID-alternate O-glycosylserine RESID-alternate O-xylosyl-L-serine RESID-name O3-xylosylserine RESID-alternate OXylSer PSI-MOD-label DiffAvg 132.12 DiffFormula C 5 H 8 N 0 O 4 DiffMono 132.042259 Formula C 8 H 13 N 1 O 6 MassAvg 219.19 MassMono 219.074287 Origin S Source artifact TermSpec none MOD:00002 PSI-MOD MOD:00815 molybdopterin OBSOLETE because redundant with MOD:00151. Remap to MOD:00151. 14527393 PubMed 7878465 PubMed 9428520 PubMed DiffAvg 520.27 DiffFormula C 10 H 11 Mo 1 N 5 O 8 P 1 S 2 DiffMono 521.884074 Formula none MassAvg none MassMono none Origin C Source natural TermSpec none 1 PSI-MOD MOD:00816 S-stearoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-stearoyl-L-cysteine. 0 DeltaMass 2371783 PubMed 3143715 PubMed 8761467 PubMed AA0407 RESID From DeltaMass: Average Mass: 266 PSI-MOD-slim (R)-2-amino-3-(octadecanoylsulfanyl)propanoic acid RESID-systematic 2-amino-3-(octadecanoylthio)propanoic acid RESID-alternate cysteine octadecanoate thioester RESID-alternate cysteine stearate thioester RESID-alternate LIPID S-stearoyl cysteine UniProt-feature S-stearoyl-L-cysteine RESID-name SSteCys PSI-MOD-label Stearoylation DeltaMass-label DiffAvg 266.47 DiffFormula C 18 H 34 N 0 O 1 S 0 DiffMono 266.260966 Formula C 21 H 39 N 1 O 2 S 1 MassAvg 369.61 MassMono 369.270150 Origin C Source natural TermSpec none MOD:00672 MOD:00905 MOD:01155 PSI-MOD MOD:00817 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan. 35304 ChEBI 16407988 PubMed 8168130 PubMed AA0408 RESID (2S,3aR,8aS)-3a-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid RESID-systematic (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophan RESID-alternate 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan RESID-name 3'Ger2'N2cycTrp PSI-MOD-label LIPID 3'-geranyl-2',N2-cyclotryptophan UniProt-feature DiffAvg 136.24 DiffFormula C 10 H 16 N 0 O 0 DiffMono 136.125201 Formula C 21 H 26 N 2 O 1 MassAvg 322.45 MassMono 322.204513 Origin W Source natural TermSpec none MOD:00601 MOD:01115 PSI-MOD MOD:00818 glycosylphosphatidylinositolated residue A protein modification that effectively converts a residue to a glycosylphosphatidylinositolethanolamidated. 12643538 PubMed 394#C-term UniMod glycosylphosphatidylinositol UniMod-description GPIanchor UniMod-interim GPIRes PSI-MOD-label DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula none MassAvg none MassMono none Origin X Source natural TermSpec C-term MOD:00764 MOD:00861 MOD:01155 PSI-MOD MOD:00819 L-2-aminobutanoic acid (Glu) A protein modification that effectively converts an L-glutamic acid residue to L-2-aminobutanoic acid. 35619 ChEBI 0 DeltaMass 11740505 PubMed AA0409 RESID (S)-2-aminobutanoic acid RESID-systematic Abu DeltaMass-label Abu PSI-MOD-label alpha-amino-n-butyric acid PSI-MOD-alternate alpha-aminobutyric acid PSI-MOD-alternate butyrine PSI-MOD-alternate dCbxGlu PSI-MOD-alternate L-2-amino-n-butyric acid RESID-alternate L-2-aminobutanoic acid RESID-name L-2-aminobutyric acid RESID-alternate L-alpha-amino-n-butyric acid RESID-alternate L-alpha-aminobutyric acid RESID-alternate L-butyrine RESID-alternate DiffAvg -44.01 DiffFormula C -1 H 0 N 0 O -2 DiffMono -43.989829 Formula C 4 H 7 N 1 O 1 MassAvg 85.11 MassMono 85.052764 Origin E Source natural TermSpec none MOD:00906 PSI-MOD MOD:00820 2-imino-alanine 5-imidazolinone glycine A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue to form 2-imino-alanine 5-imidazolinone glycine. 16627946 PubMed AA0410 RESID Cross-link 2; carboxamidine. (2-ethanimidoyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid RESID-systematic 2,N-didehydroalanyl-5-imidazolinone glycine RESID-alternate 2-(1-iminoethyl)-1-carboxymethyl-1-imidazolin-5-one RESID-alternate 2-imino-alanine 5-imidazolinone glycine RESID-name 2-imino-alanyl-5-imidazolinone glycine RESID-alternate [2-(1-iminoethyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid RESID-alternate alanyl-5-imidazolinone glycine RESID-alternate para-hydroxybenzylidene-imidazolidinone chromophore RESID-alternate red fluorescent protein zRFP574 chromophore RESID-alternate DiffAvg -64.04 DiffFormula C -1 H -4 N 0 O -3 DiffMono -64.016044 Formula C 5 H 4 N 2 O 1 MassAvg 108.10 MassMono 108.032363 Origin D, G Source natural TermSpec none MOD:00904 MOD:00908 MOD:01882 PSI-MOD MOD:00821 S-(L-alanyl)-L-cysteine A protein modification that effectively crosslinks an L-alanine residue and an L-cysteine residue by a thioester bond to form S-(L-alanyl)-L-cysteine. 11807079 PubMed AA0411 RESID Cross-link 2. (2R)-2-amino-3-([(2S)-2-aminopropanoyl]sulfanyl)propanoic acid RESID-systematic alanine cysteine thioester RESID-alternate CROSSLNK Alanyl cysteine thioester (Cys-Ala) UniProt-feature S-(2-aminopropanoyl)cysteine RESID-alternate S-(L-alanyl)-L-cysteine RESID-name XLNK1AlaSCys PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 9 N 2 O 2 S 1 MassAvg 173.21 MassMono 173.038474 Origin A, C Source hypothetical TermSpec C-term MOD:00395 MOD:00901 MOD:00954 PSI-MOD MOD:00822 S-(L-leucyl)-L-cysteine A protein modification that effectively crosslinks an L-leucine residue and an L-cysteine residue by a thioester bond to form S-(L-leucyl)-L-cysteine. 12591958 PubMed AA0412 RESID Cross-link 2. (2R)-2-amino-3-([(2S)-2-amino-4-methylpentanoyl]sulfanyl)propanoic acid RESID-systematic CROSSLNK Leucyl cysteine thioester (Cys-Leu) UniProt-feature leucine cysteine thioester RESID-alternate S-(2-amino-4-methylpentanoyl)cysteine RESID-alternate S-(L-leucyl)-L-cysteine RESID-name XLNK1LeuSCys PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 9 H 15 N 2 O 2 S 1 MassAvg 215.29 MassMono 215.085424 Origin C, L Source natural TermSpec C-term MOD:00395 MOD:00911 MOD:00954 PSI-MOD MOD:00823 S-(L-methionyl)-L-cysteine A protein modification that effectively crosslinks an L-methionine residue and an L-cysteine residue by a thioester bond to form S-(L-methionyl)-L-cysteine. 12146974 PubMed AA0413 RESID Cross-link 2. (2R)-2-amino-3-([(2S)-2-amino-4-(methylsulfanyl)butanoyl]sulfanyl)propanoic acid RESID-systematic CROSSLNK Methionyl cysteine thioester (Cys-Met) UniProt-feature methionine cysteine thioester RESID-alternate S-(2-amino-4-methylthiobutanoyl)cysteine RESID-alternate S-(L-methionyl)-L-cysteine RESID-name XLNK1MetSCys PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 8 H 13 N 2 O 2 S 2 MassAvg 233.32 MassMono 233.041845 Origin C, M Source natural TermSpec C-term MOD:00395 MOD:00913 MOD:00954 PSI-MOD MOD:00824 dehydroalanine (Tyr) A protein modification that effectively converts an L-tyrosine residue to dehydroalanine. 10220322 PubMed 1547888 PubMed 1815586 PubMed 2914619 PubMed 6838602 PubMed 7947813 PubMed 8239649 PubMed AA0181#TYR RESID 400 UniMod incidental to RESID:AA0178 2,3-didehydroalanine RESID-alternate 2-aminoacrylic acid RESID-alternate 2-aminopropenoic acid RESID-systematic 4-methylidene-imidazole-5-one (MIO) active site RESID-alternate anhydroserine RESID-alternate dehydroalanine RESID-name Dha RESID-alternate dHAla(Tyr) PSI-MOD-label DiffAvg -94.11 DiffFormula C -6 H -6 N 0 O -1 DiffMono -94.041865 Formula C 3 H 3 N 1 O 1 MassAvg 69.06 MassMono 69.021464 Origin Y Source natural TermSpec none MOD:00919 MOD:01168 PSI-MOD MOD:00825 S-(L-phenylalanyl)-L-cysteine A protein modification that effectively crosslinks an L-phenylalanine residue and an L-cysteine residue by a thioester bond to form S-(L-phenylalaninyl)-L-cysteine. 12591958 PubMed AA0414 RESID Cross-link 2. (2R)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]sulfanyl)propanoic acid RESID-systematic CROSSLNK Phenylalanyl cysteine thioester (Cys-Phe) UniProt-feature phenylalanine cysteine thioester RESID-alternate S-(2-amino-3-phenylpropanoyl)cysteine RESID-alternate S-(L-phenylalanyl)-L-cysteine RESID-name XLNK1PheSCys PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 12 H 13 N 2 O 2 S 1 MassAvg 249.31 MassMono 249.069774 Origin C, F Source natural TermSpec C-term MOD:00395 MOD:00914 MOD:00954 PSI-MOD MOD:00826 S-(L-threonyl)-L-cysteine A protein modification that effectively crosslinks an L-threonine residue and an L-cysteine residue by a thioester bond to form S-(L-threonyl)-L-cysteine. 15268951 PubMed AA0415 RESID Cross-link 2. (2R)-2-amino-3-([(2S,3R)-2-amino-3-hydroxybutanoyl]sulfanyl)propanoic acid RESID-systematic CROSSLNK Threonyl cysteine thioester (Cys-Thr) UniProt-feature S-(2-amino-3-hydroxybutanoyl)cysteine RESID-alternate S-(L-threonyl)-L-cysteine RESID-name threonine cysteine thioester RESID-alternate XLNK1ThrSCys PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 7 H 11 N 2 O 3 S 1 MassAvg 203.24 MassMono 203.049038 Origin C, T Source natural TermSpec C-term MOD:00395 MOD:00917 MOD:00954 PSI-MOD MOD:00827 S-(L-tyrosyl)-L-cysteine A protein modification that effectively crosslinks an L-tyrosine residue and an L-cysteine residue by a thioester bond to form S-(L-tyrosyl)-L-cysteine. 11807079 PubMed AA0416 RESID Cross-link 2. (2R)-2-amino-3-([(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfanyl)propanoic acid RESID-systematic CROSSLNK Tyrosyl cysteine thioester (Cys-Tyr) UniProt-feature S-(L-tyrosyl)-L-cysteine RESID-name S-[2-amino-3-(4-hydoxyphenyl)propanoyl]cysteine RESID-alternate tyrosine cysteine thioester RESID-alternate XLNK1TyrSCys PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 12 H 13 N 2 O 3 S 1 MassAvg 265.31 MassMono 265.064688 Origin C, Y Source natural TermSpec C-term MOD:00395 MOD:00919 MOD:00954 PSI-MOD MOD:00828 S-(L-tryptophanyl)-L-cysteine A protein modification that effectively crosslinks an L-tryptophan residue and an L-cysteine residue by a thioester bond to form S-(L-tryptophanyl)-L-cysteine. 16030216 PubMed AA0417 RESID Cross-link 2. (2R)-2-amino-3-([(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]sulfanyl)propanoic acid RESID-systematic CROSSLNK Tryptophanyl cysteine thioester (Cys-Trp) UniProt-feature S-(L-tryptophanyl)-L-cysteine RESID-name S-[2-amino-3-(1H-indol-3-yl)propanoyl]cysteine RESID-alternate tryptophan cysteine thioester RESID-alternate XLNK1TrpSCys PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 14 H 14 N 3 O 2 S 1 MassAvg 288.35 MassMono 288.080673 Origin C, W Source natural TermSpec C-term MOD:00395 MOD:00918 MOD:00954 PSI-MOD MOD:00829 O-(L-phenylalanyl)-L-serine A protein modification that effectively crosslinks an L-phenylalanine residue and an L-serine residue by an ester bond to form S-(L-phenylalaninyl)-L-serine. 12591958 PubMed AA0418 RESID Cross-link 2. (2S)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]oxy)propanoic acid RESID-systematic CROSSLNK Phenylalanyl serine ester (Ser-Phe) UniProt-feature O-(2-amino-3-phenylpropanoyl)serine RESID-alternate O-(L-phenylalanyl)-L-serine RESID-name phenylalanine serine ester RESID-alternate XLNK1PheOSer PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 12 H 13 N 2 O 3 MassAvg 233.25 MassMono 233.092617 Origin F, S Source natural TermSpec C-term MOD:00885 MOD:00914 MOD:00916 MOD:00954 PSI-MOD MOD:00830 N-methyl-L-proline A protein modification that effectively converts an L-proline residue to an N-methyl-L-proline. 3127388 PubMed AA0419 RESID Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. PSI-MOD-slim (S)-1-methylpyrrolidine-2-carboxylic acid RESID-systematic 1-methylpyrrolidine-2-carboxylic acid RESID-alternate hygric acid RESID-alternate MOD_RES N-methylproline UniProt-feature N-methyl-L-proline RESID-name N-methylated L-proline PSI-MOD-alternate NMePro PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 6 H 10 N 1 O 1 MassAvg 112.15 MassMono 112.076239 Origin P Source natural TermSpec N-term MOD:01417 MOD:01462 MOD:01680 PSI-MOD MOD:00831 N4-(N-acetylamino)glucosyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine. 111247 PubMed 1694179 PubMed 5490222 PubMed AA0151#var RESID PSI-MOD-slim HexNAc PSI-MS-label N4GlcNAcAsn PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 12 H 19 N 3 O 7 MassAvg 317.30 MassMono 317.122300 Origin N Source natural TermSpec none MOD:00448 MOD:01674 PSI-MOD MOD:00832 N4-(N-acetylamino)galactosyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminogalactosyl)-L-asparagine. 8262914 PubMed AA0420 RESID (2S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid RESID-systematic HexNAc PSI-MS-label N4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-asparagine RESID-alternate N4-(2-acetylamino-2-deoxy-beta-D-galactopyranosyl)-L-asparagine RESID-alternate N4-(N-acetylamino)galactosyl-L-asparagine RESID-name N4-(N-acetylgalactosaminyl)asparagine RESID-alternate N4-asparagine-beta-N-acetylgalactosaminide RESID-alternate N4-glycosyl-L-asparagine RESID-alternate N4-glycosylasparagine RESID-alternate N4GalNAcAsn PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 12 H 19 N 3 O 7 MassAvg 317.30 MassMono 317.122300 Origin N Source natural TermSpec none MOD:00563 MOD:01674 PSI-MOD MOD:00833 N4-glucosyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-glucosyl-asparagine. 1569073 PubMed 3410849 PubMed AA0421 RESID (2S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid RESID-systematic CARBOHYD N-linked (Glc) UniProt-feature N4-(D-glucopyranosyl)-L-asparagine RESID-alternate N4-asparagine-glucoside RESID-alternate N4-glucosyl-L-asparagine RESID-name N4-glucosylasparagine RESID-alternate N4-glycosyl-L-asparagine RESID-alternate N4-glycosylasparagine RESID-alternate N4GlcAsn PSI-MOD-label DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 10 H 16 N 2 O 7 MassAvg 276.25 MassMono 276.095751 Origin N Source natural TermSpec none MOD:00433 MOD:00761 MOD:01346 PSI-MOD MOD:00834 O-(N-acetylamino)fucosyl-L-serine A protein modification that effectively converts an L-serine residue to O3-(N-acetamino)fucosylserine. 11342554 PubMed 12010970 PubMed AA0422 RESID PSI-MOD-slim (2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-fucopyranosyloxy)propanoic acid RESID-systematic O-(2-acetylamino-2-deoxy-beta-D-fucopyranosyl)-L-serine RESID-alternate O-(N-acetylamino)fucosyl-L-serine RESID-name O-(N-acetylfucosaminyl)serine RESID-alternate O-seryl-beta-N-acetylfucosaminide RESID-alternate O3-(2-acetamido-2-deoxy-beta-D-fucopyranosyl)-L-serine RESID-alternate O3-(N-acetylfucosaminyl)serine RESID-alternate OFucNAcSer PSI-MOD-label DiffAvg 187.19 DiffFormula C 8 H 13 N 1 O 4 DiffMono 187.084458 Formula C 11 H 18 N 2 O 6 MassAvg 274.27 MassMono 274.116486 Origin S Source natural TermSpec none MOD:00002 PSI-MOD MOD:00835 L-3-oxoalanine (Ser) A protein modification that effectively converts an L-serine residue to L-oxoalanine. 349 DeltaMass 14563551 PubMed 7628016 PubMed 8681943 PubMed 9276974 PubMed 9478923 PubMed AA0185#SER RESID 401#S UniMod PSI-MOD-slim (S)-2-amino-3-oxopropanoic acid RESID-systematic 2-amino-3-oxopropionic acid RESID-alternate C(alpha)-formylglycine RESID-misnomer dehydrogenated serine residue UniMod-description Didehydro PSI-MS-label formylglycine UniMod-alternate formylglycine (from serine) DeltaMass-label L-3-oxoalanine RESID-name L-amino-malonic acid semialdehyde RESID-alternate L-aminomalonaldehydic acid RESID-alternate L-serinesemialdehyde RESID-misnomer MOD_RES 3-oxoalanine (Ser) UniProt-feature oxoalanine UniMod-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 3 H 3 N 1 O 2 MassAvg 85.06 MassMono 85.016378 Origin S Source natural TermSpec none MOD:00916 MOD:01169 MOD:01888 PSI-MOD MOD:00836 deuterium disubstituted residue A protein modification that effectively substitutes two (2)H deuterium atoms for two (1)H protium atoms. 18688235 PubMed PSI-MOD-slim D(H)2Res PSI-MOD-label MOD:00786 PSI-MOD MOD:00837 deuterium tetrasubstituted residue A protein modification that effectively substitutes four (2)H deuterium atoms for four (1)H protium atoms. 18688235 PubMed D(H)4Res PSI-MOD-label MOD:00786 PSI-MOD MOD:00838 3x(2)H labeled L-leucine A protein modification that effectively substitutes three (1)H protium atoms with three (2)H deuterium atoms to produce 3x(2)H labeled L-leucine. 262#L UniMod D(H)3Leu PSI-MOD-label Label:2H(3) PSI-MS-label Trideuteration UniMod-description DiffAvg 3.02 DiffFormula (1)H -3 (2)H 3 DiffMono 3.018830 Formula C 6 (1)H 8 (2)H 3 N 1 O 1 MassAvg 116.10 MassMono 116.102894 Origin L Source artifact TermSpec none MOD:00585 MOD:00911 PSI-MOD MOD:00839 (2)H deuterium labeled residue A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing deuteriumm, (2)H. 18688235 PubMed PSI-MOD-slim MOD:00702 PSI-MOD MOD:00840 isocyanate reagent derivatized residue A protein modification produced by formation of an adduct with an isocyanate compound. 18688235 PubMed PSI-MOD-slim MOD:00848 PSI-MOD MOD:00841 isothiocyanate reagent derivatized residue A protein modification produced by formation of an adduct with an isothiocyanate compound. 18688235 PubMed PSI-MOD-slim MOD:00848 PSI-MOD MOD:00842 (13)C labeled residue A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (13)C. 18688235 PubMed PSI-MOD-slim MOD:00702 PSI-MOD MOD:00843 (15)N labeled residue A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (15)N. 18688235 PubMed PSI-MOD-slim MOD:00702 PSI-MOD MOD:00844 (18)O labeled residue A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (18)O. 18688235 PubMed PSI-MOD-slim MOD:00702 PSI-MOD MOD:00845 (18)O substituted residue A protein modification that effectively substitutes one or more (18)O atoms for (16)O atoms. 18688235 PubMed PSI-MOD-slim MOD:00844 PSI-MOD MOD:00846 levuglandinyl (prostaglandin H2) adduct stub 18688235 PubMed MOD:00848 PSI-MOD MOD:00847 (18)O disubstituted residue A protein modification that effectively substitutes two (18)O atom for two (16)O atoms. 18688235 PubMed PSI-MOD-slim MOD:00845 PSI-MOD MOD:00848 reagent derivatized residue A protein modification that is produced by formation of an adduct with a particular compound used as a reagent. 18688235 PubMed PSI-MOD-slim MOD:01156 PSI-MOD MOD:00849 potassium containing modified residue A protein modification that effectively substitutes a potassium atom for a hydrogen atom. 18688235 PubMed PSI-MOD-slim KRes PSI-MOD-label MOD:00698 PSI-MOD MOD:00850 unnatural residue A protein modification that inserts or replaces a residue with an unnatural residue that is not considered to be derived from a natural residue by some chemical process. 18688235 PubMed PSI-MOD-slim MOD:01157 PSI-MOD MOD:00851 (18)O labeled deamidated residue A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with (18)O. 18688235 PubMed PSI-MOD-slim Origin X Source artifact TermSpec none MOD:00400 MOD:00844 PSI-MOD MOD:00852 1x(18)O labeled deamidated residue A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with one (18)O. 8382902 PubMed 366 UniMod PSI-MOD-slim DiffAvg 2.99 DiffFormula H -1 N -1 (18)O 1 DiffMono 2.988262 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00851 PSI-MOD MOD:00853 2x(18)O labeled deamidated residue A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with two (18)O. 18688235 PubMed PSI-MOD-slim DiffAvg 4.99 DiffFormula H -1 N -1 (16)O -1 (18)O 2 DiffMono 4.992508 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00851 PSI-MOD MOD:00854 protonated L-lysine (L-lysinium) residue A protein modification that effectively converts an L-lysine to L-lysinium (protonated L-lysine). 18688235 PubMed Some sources compute the difference formula for charged, quatenary modified lysine based on protonated lysine rather than neutral lysine residue. In such cases, a comparable difference formula can be calculated based on this derivative. PSI-MOD-slim DiffAvg 1.01 DiffFormula C 0 H 1 N 0 O 0 DiffMono 1.007276 FormalCharge 1+ Formula C 6 H 13 N 2 O 1 MassAvg 129.18 MassMono 129.102239 Origin K Source natural TermSpec none MOD:00912 MOD:01699 PSI-MOD MOD:00855 N6,N6,N6-trimethyl-L-lysine (from L-lysinium residue) A protein modification that effectively converts an L-lysinium (N6-protonated L-lysine) residue to an N6,N6,N6-trimethyl-L-lysine. 0 DeltaMass 12590383 PubMed 3145979 PubMed 4304194 PubMed 6778808 PubMed 7093227 PubMed 8453381 PubMed 37#K UniMod For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N6Me3+Lys process (MOD:00083) accounts for both protonation and trimethylation. PSI-MOD-slim N6Me3Lys PSI-MOD-label trimethylk OMSSA-label DiffAvg 42.08 DiffFormula C 3 H 6 N 0 O 0 DiffMono 42.046402 FormalCharge 1+ Formula C 9 H 19 N 2 O 1 MassAvg 171.26 MassMono 171.149190 Origin MOD:00854 Source natural TermSpec none MOD:00430 derives_from MOD:008540 PSI-MOD MOD:00856 protonated L-alanine (L-alaninium) residue A protein modification that effectively converts an L-alanine residue to an L-alaninium (protonated L-alanine). 18688235 PubMed PSI-MOD-slim DiffAvg 1.01 DiffFormula C 0 H 1 N 0 O 0 DiffMono 1.007276 FormalCharge 1+ Formula C 3 H 7 N 1 O 1 MassAvg 73.09 MassMono 73.052215 Origin A Source natural TermSpec N-term MOD:00901 MOD:01700 PSI-MOD MOD:00857 N,N,N-trimethyl-L-alanine (from L-alaninium) A protein modification that effectively converts an L-alaninium (protonated L-alanine) residue to an N,N,N-trimethyl-L-alanine. 12590383 PubMed 332162 PubMed 3979397 PubMed 6778808 PubMed 7715456 PubMed 37#A UniMod For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ala process (MOD:00071) accounts for both protonation and trimethylation. PSI-MOD-slim N2Me3Ala PSI-MOD-label DiffAvg 42.08 DiffFormula C 3 H 6 N 0 O 0 DiffMono 42.046402 FormalCharge 1+ Formula C 6 H 13 N 1 O 1 MassAvg 115.18 MassMono 115.099165 Origin MOD:00856 Source natural TermSpec N-term MOD:01687 derives_from MOD:008560 PSI-MOD MOD:00858 D-alanine (Ser) A protein modification that effectively converts an L-serine residue to D-alanine. 7961627 PubMed AA0191#SER RESID (R)-2-aminopropanoic acid RESID-systematic D-Ala(Ser) PSI-MOD-label D-alanine RESID-name MOD_RES D-alanine (Ser) UniProt-feature DiffAvg -16.00 DiffFormula C 0 H 0 N 0 O -1 DiffMono -15.994915 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin S Source natural TermSpec none MOD:00862 MOD:00916 MOD:01161 PSI-MOD MOD:00859 modified residue that can arise from different natural residues A protein modification that can be derived from different natural residues by different chemical processes. 18688235 PubMed PSI-MOD-slim Origin X Source natural TermSpec none MOD:01157 PSI-MOD MOD:00860 sulfur containing modified residue A protein modification that produces an amino acid residue containing an exogenous sulfur atom. 18688235 PubMed PSI-MOD-slim MOD:01156 PSI-MOD MOD:00861 phosphorus containing modified residue A protein modification that produces an amino acid residue containing a phosphorus atom. 18688235 PubMed PSI-MOD-slim MOD:01156 PSI-MOD MOD:00862 D-alanine A protein modification that effectively converts a source amino acid residue to D-alanine. 29949 ChEBI 7287302 PubMed 7961627 PubMed AA0191 RESID (R)-2-aminopropanoic acid RESID-systematic D-alanine RESID-name MOD_RES D-alanine (Ala) UniProt-feature MOD_RES D-alanine (Ser) UniProt-feature DiffAvg none DiffFormula none DiffMono none Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin X Source natural TermSpec none MOD:00664 MOD:00859 PSI-MOD MOD:00863 D-allo-threonine A protein modification that effectively converts an L-threonine residue to D-allo-threonine. 32826 ChEBI 18025465 PubMed 6893271 PubMed AA0199 RESID (2R,3R)-2-amino-3-hydroxybutanoic acid RESID-systematic D-Thr PSI-MOD-label D-threonine RESID-name MOD_RES D-threonine UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 7 N 1 O 2 MassAvg 101.10 MassMono 101.047678 Origin T Source natural TermSpec none MOD:00664 MOD:00917 PSI-MOD MOD:00864 tris-L-cysteinyl L-histidino diiron disulfide A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-histidino diiron disulfide. 17766439 PubMed 17766440 PubMed AA0438 RESID Cross-link 4. CDGSH domain iron-sulfur cluster RESID-alternate di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-N3'-histidinoiron) RESID-systematic METAL Iron-sulfur (2Fe-2S) UniProt-feature METAL Iron-sulfur (2Fe-2S); via pros nitrogen UniProt-feature tris-L-cysteinyl L-histidino diiron disulfide RESID-name DiffAvg 171.78 DiffFormula C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono 171.783814 FormalCharge 2- Formula C 15 Fe 2 H 18 N 6 O 4 S 5 MassAvg 618.34 MassMono 617.870280 Origin C, C, C, H Source natural TermSpec none MOD:00739 MOD:00905 MOD:00909 PSI-MOD MOD:00865 N-aspartyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-aspartic acid residue to N-aspartyl-glycosylsphingolipidinositolethanolamine. AA0439 RESID GSIAsp PSI-MOD-label LIPID GPI-like-anchor amidated aspartate UniProt-feature N-aspartyl-glycosylsphingolipidinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 6 H 12 N 2 O 7 P 1 MassAvg 255.14 MassMono 255.038212 Origin D Source hypothetical TermSpec C-term MOD:00466 MOD:00904 PSI-MOD MOD:00866 dihydroxylated proline A protein modification that effectively converts an L-proline residue to one of several dihydroxylated proline residues, such as (2S,3R,4R)-3,4-dihydroxyproline or (2S,3R,4S)-3,4-dihydroxyproline. 18688235 PubMed Hy2Pro PSI-MOD-label DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin P Source natural TermSpec none MOD:00428 MOD:00678 PSI-MOD MOD:00867 L-cysteinyl-L-selenocysteine (Cys-Cys) A protein modification that effectively cross-links an L-cysteine residue and an L-cysteine converted to an L-selenocysteine residue to form L-cysteinyl-L-selenocystine. 10801974 PubMed 12911312 PubMed 17177418 PubMed AA0358#CYS RESID Cross-link 2. (R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid RESID-systematic CROSSLNK Cysteinyl-selenocysteine (Cys-Sec) UniProt-feature CROSSLNK Cysteinyl-selenocysteine (Sec-Cys) UniProt-feature L-cysteinyl-L-selenocysteine RESID-name DiffAvg 44.90 DiffFormula C 0 H -2 N 0 O 0 S -1 Se 1 DiffMono 45.928800 Formula C 6 H 8 N 2 O 2 S 1 Se 1 MassAvg 251.17 MassMono 251.947170 Origin C, C Source natural TermSpec none MOD:00007 MOD:01627 PSI-MOD MOD:00868 natural, non-standard encoded residue A protein modification that inserts or replaces a residue with a natural, non-standard encoded residue, such as N-formyl-L-methionine, L-selenocysteine, or L-pyrrolysine. 18688235 PubMed These are produced exclusively by modification of amino acids acylated to special tRNA before incorporation by ribosomes into proteins. For this reason, they have also been referred to as pre-translational modifications. PSI-MOD-slim Origin X Source natural MOD:00009 PSI-MOD MOD:00869 L-alanine residue (Asp) A protein modification that effectively converts an L-aspartic acid residue to L-alanine. 17138938 PubMed AA0001#ASP RESID This has been reported to occur by a natural process of beta-decarboxylation. (2S)-2-aminopropanoic acid RESID-systematic 2-aminopropionic acid RESID-alternate 2-azanylpropanoic acid RESID-alternate alpha-alanine RESID-alternate alpha-aminopropionic acid RESID-alternate Asp(Ala) PSI-MOD-label L-alanine RESID-name MOD_RES Beta-decarboxylated aspartate UniProt-feature DiffAvg -44.01 DiffFormula C -1 H 0 N 0 O -2 DiffMono -43.989829 Formula C 3 H 5 N 1 O 1 MassAvg 71.08 MassMono 71.037114 Origin D Source natural TermSpec none MOD:00010 MOD:00904 PSI-MOD MOD:00870 phenyl isocyanate derivatized residue A protein modification produced by formation of an adduct with phenyl isocyanate. 411 UniMod From UniMod with no citation. PSI-MOD-slim phenyl isocyanate UniMod-description Phenylisocyanate PSI-MS-label DiffAvg 119.12 DiffFormula C 7 H 5 N 1 O 1 DiffMono 119.037114 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00840 PSI-MOD MOD:00871 (2)H5-phenyl isocyanate derivatized residue A protein modification produced by formation of an adduct with (2)H5-phenyl isocyanate. 412 UniMod From UniMod with no citation. PSI-MOD-slim d5-phenyl isocyanate UniMod-description Phenylisocyanate:2H(5) PSI-MS-label DiffAvg 124.07 DiffFormula C 7 (2)H 5 N 1 O 1 DiffMono 124.068498 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00870 MOD:01431 PSI-MOD MOD:00872 L-isoglutamyl monoglutamic acid OBSOLETE because redundant and identical to MOD:01970. Remap to MOD:01970. 10747868 PubMed 15525938 PubMed 1680872 PubMed AA0202#var RESID 450 UniMod Glu UniMod-interim monoglutamyl UniMod-description N alpha -(gamma-Glutamyl)-Glu DeltaMass-label DiffAvg 129.12 DiffFormula C 5 H 7 N 1 O 3 DiffMono 129.042593 Formula C 10 H 14 N 2 O 6 MassAvg 258.23 MassMono 258.085186 Origin E Source natural TermSpec none 1 PSI-MOD MOD:00873 L-isoglutamyl diglutamic acid A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamic acid, forming an isopeptide bond with a diglutamic acid. 0 DeltaMass 10747868 PubMed 1680872 PubMed AA0202#var RESID 451 UniMod diglutamyl UniMod-description GluGlu UniMod-interim DiffAvg 258.23 DiffFormula C 10 H 14 N 2 O 6 DiffMono 258.085186 Formula C 15 H 21 N 3 O 9 MassAvg 387.35 MassMono 387.127779 Origin E Source natural TermSpec none MOD:00207 PSI-MOD MOD:00874 L-isoglutamyl triglutamic acid A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a triglutamic acid. 0 DeltaMass 10747868 PubMed 1680872 PubMed AA0202#var RESID 452 UniMod From DeltaMass: Average Mass: 388. GluGluGlu UniMod-interim N alpha -(gamma-Glutamyl)-Glu3 DeltaMass-label triglutamyl UniMod-description DiffAvg 387.35 DiffFormula C 15 H 21 N 3 O 9 DiffMono 387.127779 Formula C 20 H 28 N 4 O 12 MassAvg 516.46 MassMono 516.170372 Origin E Source natural TermSpec none MOD:00207 PSI-MOD MOD:00875 L-isoglutamyl tetraglutamic acid A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a tetraglutamic acid. 10747868 PubMed 1680872 PubMed AA0202#var RESID 453 UniMod GluGluGluGlu UniMod-interim tetraglutamyl UniMod-description DiffAvg 516.46 DiffFormula C 20 H 28 N 4 O 12 DiffMono 516.170372 Formula C 25 H 35 N 5 O 15 MassAvg 645.57 MassMono 645.212965 Origin E Source natural TermSpec none MOD:00207 PSI-MOD MOD:00876 hexosaminylated residue A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosamine sugar group through a glycosidic bond. 454 UniMod HexN PSI-MS-label Hexosamine UniMod-description Hexosamines (GalN, GlcN) DeltaMass-label DiffAvg 161.16 DiffFormula C 6 H 11 N 1 O 4 DiffMono 161.068808 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00877 imidoester crosslink dimethyl pimelimidate singly attached dimethyl pimelimidate modification from UniMod 455 UniMod One end of crosslink attached, one end free UniMod-description Xlink:DMP-s UniMod-interim DiffAvg 154.21 DiffFormula C 8 H 14 N 2 O 1 DiffMono 154.110613 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00878 imidoester crosslink dimethyl pimelimidate doubly attached dimethyl pimelimidate modification from UniMod - Mechanism of the reaction of imidoesters with amines 7171546 PubMed 456 UniMod Both ends of crosslink attached to same peptide UniMod-description Xlink:DMP UniMod-interim DiffAvg 122.17 DiffFormula C 7 H 10 N 2 DiffMono 122.084398 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00879 naphthalene-2,3-dicarboxaldehyde modification from UniMod 2081203 PubMed 457 UniMod naphthalene-2,3-dicarboxaldehyde UniMod-description NDA UniMod-interim DiffAvg 175.19 DiffFormula C 13 H 5 N 1 DiffMono 175.042199 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00880 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue A protein modification produced by formation of an adduct with 6x(13)C labeled 4-sulfophenyl isothiocyanate. 15536630 PubMed 16526082 PubMed 464 UniMod 4-sulfophenyl isothiocyanate (Heavy C13) UniMod-description SPITC:13C(6) PSI-MS-label DiffAvg 220.99 DiffFormula (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 DiffMono 220.991214 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00584 MOD:01428 PSI-MOD MOD:00881 N-reductive amination-D OBSOLETE because UniMod entry 465 megerd with 199. Remap to MOD:00552 DiMethyl-CH2D. 9252331 PubMed 465 UniMod DiffAvg 32.06 DiffFormula C 2 (2)H 4 DiffMono 32.056407 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none 1 PSI-MOD MOD:00882 S-(2-aminoethyl)cysteine (Ser) A protein modification that effectively converts an L-serine residue to S-(2-aminoethyl)cysteine. 171 DeltaMass 12923550 PubMed 472#S UniMod From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. AEC-MAEC UniMod-interim Aminoethyl Cysteinyl (AECys) DeltaMass-label aminoethylcysteine UniMod-description DiffAvg 59.13 DiffFormula C 2 H 5 N 1 O -1 S 1 DiffMono 59.019356 Formula C 5 H 10 N 2 O 1 S 1 MassAvg 146.21 MassMono 146.051384 Origin S Source artifact TermSpec none MOD:00916 PSI-MOD MOD:00883 C1-amidated residue A protein modification that effectively replaces a 1-carboxyl group (usually referred to as the alpha-carboxyl) with a carboxamido group. 0 DeltaMass 2 UniMod The normal biological process involves formation of an amide of an amino acid residue in a peptide sequence where it is followed by a glycine and two basic residues, either arginine or lysine, although in some taxa only one basic residue is required. The peptide is cleaved after the basic residues, glycine is oxidized to hydroxyglycine, which decomposes to release a carboxamide C-terminal [JSG]. PSI-MOD-slim alpha-amidated residue PSI-MOD-alternate Amidated PSI-MS-label Amidation UniMod-description Amide formation (C terminus) DeltaMass-label ctermamide OMSSA-label ResN PSI-MOD-label DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula none MassAvg none MassMono none Origin X Source natural TermSpec C-term MOD:00674 PSI-MOD MOD:00884 S-aminoethylcysteine (Cys) A protein modification that effectively converts an L-cysteine residue to S-2-aminoethylcysteine. 1175632 PubMed 18688235 PubMed This modified residue is a chemical isolog of L-lysine for trypsin hydolysis produced from L-cysteine by aziridine. PSI-MOD-slim 4-thialysine PSI-MOD-alternate L-cysteine aziridine adduct PSI-MOD-alternate S-(2-aminoethyl)-L-cysteine PSI-MOD-alternate DiffAvg 43.07 DiffFormula C 2 H 5 N 1 O 0 S 0 DiffMono 43.042199 Formula C 5 H 10 N 2 O 1 S 1 MassAvg 146.21 MassMono 146.051384 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00885 ester crosslinked residues A protein modification that crosslinks two residues by formation of an ester bond. 18688235 PubMed MOD:00033 PSI-MOD MOD:00886 6'-chloro-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 6'-chloro-L-tryptophan. 9033387 PubMed AA0180 RESID 936#W UniMod The UniMod:340 cross-reference to RESID:AA0180 is incorrect. RESID:AA0180 should be cross-referenced by UniMod:936 [JSG]. (2S)-2-amino-3-(6-chloro-1H-indol-3-yl)propanoic acid RESID-systematic 6'-chloro-L-tryptophan RESID-name 6'-ClTrp PSI-MOD-label MOD_RES 6'-chlorotryptophan UniProt-feature DiffAvg 34.44 DiffFormula C 0 Cl 1 H -1 N 0 O 0 DiffMono 33.961028 Formula C 11 Cl 1 H 9 N 2 O 1 MassAvg 220.66 MassMono 220.040341 Origin W Source natural TermSpec none MOD:01913 PSI-MOD MOD:00887 methylated aspartic acid A protein modification that effectively converts an L-aspartic acid residue to a methylated aspartic acid, such as aspartic acid 4-methyl ester. 18688235 PubMed MOD:00427 MOD:00904 PSI-MOD MOD:00888 protonated L-proline (L-prolinium) residue A protein modification that effectively converts an L-proline to an L-prolinium (protonated L-proline). 18688235 PubMed PSI-MOD-slim DiffAvg 1.01 DiffFormula C 0 H 1 N 0 O 0 DiffMono 1.007276 FormalCharge 1+ Formula C 5 H 9 N 1 O 1 MassAvg 99.13 MassMono 99.067865 Origin P Source natural TermSpec N-term MOD:00915 MOD:01700 PSI-MOD MOD:00889 N,N-dimethyl-L-proline (from L-prolinium) A protein modification that effectively converts an L-prolinium (charged L-proline) residue to N,N-dimethyl-L-proline. 36#P UniMod PSI-MOD-slim DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.030752 FormalCharge 1+ Formula C 7 H 13 N 1 O 1 MassAvg 127.19 MassMono 127.099165 Origin MOD:00888 Source natural TermSpec N-term MOD:00075 derives_from MOD:008880 PSI-MOD MOD:00890 phosphorylated L-histidine A protein modification that effectively converts an L-histidine residue to a phosphorylated L-histidine, such as pros-phosphohistidine, or tele-phosphohistidine. 21#H UniMod PSI-MOD-slim mod192 OMSSA-label NPhosHis PSI-MOD-label Phospho PSI-MS-label phosphohistidine PSI-MOD-alternate DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 6 H 8 N 3 O 4 P 1 MassAvg 217.12 MassMono 217.025242 Origin H Source natural TermSpec none MOD:00909 MOD:01456 PSI-MOD MOD:00891 D-serine A protein modification that effectively converts a source amino acid residue to D-serine. 29998 ChEBI 6893271 PubMed 7973665 PubMed AA0195 RESID (R)-2-amino-3-hydroxypropanoic acid RESID-systematic D-Ser PSI-MOD-label D-serine RESID-name DiffAvg none DiffFormula none DiffMono none Formula C 3 H 5 N 1 O 2 MassAvg 87.08 MassMono 87.032028 Origin X Source natural TermSpec none MOD:00664 MOD:00859 PSI-MOD MOD:00892 D-serine (Cys) A protein modification that effectively converts an L-cysteine residue to D-serine. 18025465 PubMed 6893271 PubMed AA0195#CYS RESID (R)-2-amino-3-hydroxypropanoic acid RESID-systematic D-serine RESID-name DiffAvg -16.06 DiffFormula C 0 H 0 N 0 O 1 S -1 DiffMono -15.977156 Formula C 3 H 5 N 1 O 2 MassAvg 87.08 MassMono 87.032028 Origin C Source natural TermSpec none MOD:00891 MOD:00905 PSI-MOD MOD:00893 residues isobaric at 128.0-128.1 Natural or modified residues with a mass of 128.0-128.1 Da. 18688235 PubMed PSI-MOD-slim MOD:00616 PSI-MOD MOD:00894 residues isobaric at 128.058578 Da Natural or modified resiues with a mass of 128.058578 Da. 18688235 PubMed PSI-MOD-slim MOD:00569 MOD:00893 PSI-MOD MOD:00895 FAD modified residue A protein modification that effectively results from forming an adduct with a compound containing a flavin adenine dinucleotide (FAD) group. 18688235 PubMed PSI-MOD-slim MOD:00697 MOD:00861 PSI-MOD MOD:00896 FMN modified residue A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group. 18688235 PubMed PSI-MOD-slim MOD:00697 MOD:00861 PSI-MOD MOD:00897 N-acetyl-S-archeol-cysteine A protein modification that effectively converts an L-cysteine residue to N-acetyl-S-archeol-L-cysteine. AA0043#var RESID AA0223#var RESID DiffAvg 677.20 DiffFormula C 45 H 88 N 0 O 3 S 0 DiffMono 676.673347 Formula C 48 H 93 N 1 O 4 S 1 MassAvg 780.34 MassMono 779.682531 Origin C Source natural TermSpec N-term MOD:00905 has_functional_parent MOD:000520 has_functional_parent MOD:002280 PSI-MOD MOD:00898 S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine. 10896212 PubMed 4575979 PubMed 9056182 PubMed AA0107#var RESID 377 UniMod Incidental to RESID:AA0060. Diacylglycerol PSI-MS-label diacylglycerol UniMod-description DiffAvg 576.95 DiffFormula C 37 H 68 N 0 O 4 S 0 DiffMono 576.511761 Formula C 40 H 73 N 1 O 5 S 1 MassAvg 680.09 MassMono 679.520945 Origin C Source natural TermSpec none MOD:00116 PSI-MOD MOD:00899 N-palmitoyl-S-diacylglycerol-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-diacylglycerol-L-cysteine. AA0069#var RESID AA0107#var RESID Origin C Source natural TermSpec N-term MOD:00905 has_functional_parent MOD:000690 has_functional_parent MOD:001160 PSI-MOD MOD:00900 N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine. 18688235 PubMed (R)-2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid PSI-MOD-alternate 2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid PSI-MOD-alternate DiffAvg 815.36 DiffFormula C 53 H 98 N 0 O 5 S 0 DiffMono 814.741426 Formula C 56 H 103 N 1 O 6 S 1 MassAvg 918.50 MassMono 917.750611 Origin C Source natural TermSpec N-term MOD:00899 has_functional_parent MOD:000690 has_functional_parent MOD:008980 PSI-MOD MOD:00901 modified L-alanine residue A protein modification that modifies an L-alanine. 18688235 PubMed PSI-MOD-slim ModAla PSI-MOD-label Origin A MOD:01157 PSI-MOD MOD:00902 modified L-arginine residue A protein modification that modifies an L-arginine residue. 18688235 PubMed PSI-MOD-slim ModArg PSI-MOD-label Origin R MOD:01157 PSI-MOD MOD:00903 modified L-asparagine residue A protein modification that modifies an L-asparagine residue. 18688235 PubMed PSI-MOD-slim ModAsn PSI-MOD-label Origin N MOD:01157 PSI-MOD MOD:00904 modified L-aspartic acid residue A protein modification that modifies an L-aspartic acid residue. 18688235 PubMed PSI-MOD-slim ModAsp PSI-MOD-label Origin D MOD:01157 PSI-MOD MOD:00905 modified L-cysteine residue A protein modification that modifies an L-cysteine residue. 18688235 PubMed PSI-MOD-slim ModCys PSI-MOD-label Origin C MOD:01157 PSI-MOD MOD:00906 modified L-glutamic acid residue A protein modification that modifies an L-glutamic acid residue. 18688235 PubMed PSI-MOD-slim ModGlu PSI-MOD-label Origin E MOD:01157 PSI-MOD MOD:00907 modified L-glutamine residue A protein modification that modifies an L-glutamine residue. 18688235 PubMed PSI-MOD-slim ModGln PSI-MOD-label Origin Q MOD:01157 PSI-MOD MOD:00908 modified glycine residue A protein modification that modifies a glycine residue. 18688235 PubMed PSI-MOD-slim ModGly PSI-MOD-label Origin G MOD:01157 PSI-MOD MOD:00909 modified L-histidine residue A protein modification that modifies an L-histidine residue. 18688235 PubMed PSI-MOD-slim ModHis PSI-MOD-label Origin H MOD:01157 PSI-MOD MOD:00910 modified L-isoleucine residue A protein modification that modifies an L-isoleucine residue. 18688235 PubMed PSI-MOD-slim ModIle PSI-MOD-label Origin I MOD:01157 PSI-MOD MOD:00911 modified L-leucine residue A protein modification that modifies an L-leucine residue. 18688235 PubMed PSI-MOD-slim ModLeu PSI-MOD-label Origin L MOD:01157 PSI-MOD MOD:00912 modified L-lysine residue A protein modification that modifies an L-lysine residue. 18688235 PubMed PSI-MOD-slim ModLys PSI-MOD-label Origin K MOD:01157 PSI-MOD MOD:00913 modified L-methionine residue A protein modification that modifies an L-methionine residue. 18688235 PubMed PSI-MOD-slim ModMet PSI-MOD-label Origin M MOD:01157 PSI-MOD MOD:00914 modified L-phenylalanine residue A protein modification that modifies an L-phenylalanine residue. 18688235 PubMed PSI-MOD-slim ModPhe PSI-MOD-label Origin F MOD:01157 PSI-MOD MOD:00915 modified L-proline residue A protein modification that modifies an L-proline residue. 18688235 PubMed PSI-MOD-slim ModPro PSI-MOD-label Origin P MOD:01157 PSI-MOD MOD:00916 modified L-serine residue A protein modification that modifies an L-serine residue. 18688235 PubMed PSI-MOD-slim ModSer PSI-MOD-label Origin S MOD:01157 PSI-MOD MOD:00917 modified L-threonine residue A protein modification that modifies an L-threonine residue. 18688235 PubMed PSI-MOD-slim ModThr PSI-MOD-label Origin T MOD:01157 PSI-MOD MOD:00918 modified L-tryptophan residue A protein modification that modifies an L-tryptophan residue. 18688235 PubMed PSI-MOD-slim ModTrp PSI-MOD-label Origin W MOD:01157 PSI-MOD MOD:00919 modified L-tyrosine residue A protein modification that modifies an L-tyrosine residue. 18688235 PubMed PSI-MOD-slim ModTyr PSI-MOD-label Origin Y MOD:01157 PSI-MOD MOD:00920 modified L-valine residue A protein modification that modifies an L-valine residue. 18688235 PubMed PSI-MOD-slim ModVal PSI-MOD-label Origin V MOD:01157 PSI-MOD MOD:00921 new uncategorized UniMod entries New uncategorized UniMod. OBSOLETE because organizational use is no longer required. 18688235 PubMed 1 PSI-MOD MOD:00922 Cy3 CyDye DIGE Fluor saturation dye modification from UniMod Chemical derivative 494 UniMod Cy3 CyDye DIGE Fluor saturation dye UniMod-description CyDye-Cy3 UniMod-interim DiffAvg 672.84 DiffFormula C 37 H 44 N 4 O 6 S 1 DiffMono 672.298156 Formula C 40 H 49 N 5 O 7 S 2 MassAvg 775.98 MassMono 775.307341 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00923 Cy5 CyDye DIGE Fluor saturation dye modification from UniMod Chemical derivative 495 UniMod Cy5 CyDye DIGE Fluor saturation dye UniMod-description CyDye-Cy5 UniMod-interim DiffAvg 684.85 DiffFormula C 38 H 44 N 4 O 6 S 1 DiffMono 684.298156 Formula C 41 H 49 N 5 O 7 S 2 MassAvg 787.99 MassMono 787.307341 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00924 N6-(L-threonyl)-L-lysine A protein modification that effectively crosslinks an L-lysine residue and an L-threonine residue by an isopeptide bond to form N6-(L-threonyl)-L-lysine. 18063774 PubMed AA0440 RESID Cross-link 2. (2S)-2-amino-6-([(2S,3R)-2-amino-3-hydroxybutanoyl]amino)hexanoic acid RESID-systematic N6-(L-threonyl)-L-lysine RESID-name N6-threonyl-lysine RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 10 H 18 N 3 O 3 MassAvg 228.27 MassMono 228.134816 Origin K, T Source natural TermSpec C-term MOD:00688 MOD:00917 MOD:00954 MOD:01875 PSI-MOD MOD:00925 heptosylated residue A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a heptose sugar group through a glycosidic bond. 490 UniMod From UniMod with no citation [JSG]. Hep PSI-MS-label Heptose UniMod-description DiffAvg 192.17 DiffFormula C 7 H 12 O 6 DiffMono 192.063388 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00693 PSI-MOD MOD:00926 Bisphenol A diglycidyl ether derivative Modification from UniMod Non-standard residue. OBSOLETE because not an amino acid modification. From UniMod not an approved entry. 11225353 PubMed 493 UniMod BADGE UniMod-interim Bisphenol A diglycidyl ether derivative UniMod-description DiffAvg 340.42 DiffFormula C 21 H 24 O 4 DiffMono 340.167459 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none 1 PSI-MOD MOD:00927 2x(13)C,4x(2)H labeled dimethylated residue A protein modification that effectively replaces two hydrogen atoms of a residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated residue. 16335955 PubMed 3802193 PubMed 510 UniMod DiMethyl-C13HD2 UniMod-description Dimethyl:2H(4)13C(2) PSI-MS-label DiffAvg 34.06 DiffFormula (13)C 2 (2)H 4 DiffMono 34.063117 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00839 MOD:00842 PSI-MOD MOD:00928 [3-(2,5)-dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium modification from UniMod Chemical derivative 16771548 PubMed 513 UniMod Should have children for K and X-N-term [JSG]. [3-(2,5)-Dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium UniMod-description C8-QAT UniMod-interim DiffAvg 227.39 DiffFormula C 14 H 29 N 1 O 1 DiffMono 227.224915 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00929 lactose glycated lysine A modification produced in a non-enzymatic reaction between a lactose carbonyl group and an L-lysine to form a Schiff-base or an Amadori ketosamine lysine adduct. 9606156 PubMed 512 UniMod The term lactosylation used with this meaning is a misnomer [JSG]. Hex(2) UniMod-interim Lactosylation UniMod-description DiffAvg 342.30 DiffFormula C 12 H 22 O 11 DiffMono 342.116212 Formula C 18 H 34 N 2 O 12 MassAvg 470.47 MassMono 470.211175 Origin K Source natural TermSpec none MOD:00767 MOD:00912 PSI-MOD MOD:00930 propyl-NAG tyrosine adduct tyrosine adduct with substrate analog inhibitor 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline. 15795231 PubMed 514 UniMod DiffAvg 232.27 DiffFormula C 9 H 14 N 1 O 4 S 1 DiffMono 232.064354 Formula C 18 H 23 N 2 O 6 S 1 MassAvg 395.45 MassMono 395.127682 Origin Y Source artifact TermSpec none MOD:00848 MOD:00919 PSI-MOD MOD:00931 Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K modification from UniMod Other - BHTOH is formed upon metabolism of BHT with P450 enzymes. The BHTOH is further metabolized to its quinone methide (electrophile) which reacts with -SH and -NH2 groups 11085420 PubMed 498 UniMod BHTOH UniMod-interim Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K UniMod-description DiffAvg 234.34 DiffFormula C 15 H 22 O 2 DiffMono 234.161980 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00932 IDBEST tag for quantitation modification from UniMod Isotopic label 11821862 PubMed 499 UniMod Heavy IDBEST tag for quantitation UniMod-description IGBP:13C(2) PSI-MS-label DiffAvg 298.02 DiffFormula Br 1 (12)C 10 (13)C 2 H 13 N 2 O 2 DiffMono 298.022749 Formula Br 1 (12)C 13 (13)C 2 H 18 N 3 O 3 S 1 MassAvg 401.03 MassMono 401.031934 Origin C Source artifact TermSpec none MOD:00905 MOD:01426 PSI-MOD MOD:00933 methylglyoxal arginine adduct (+54 amu) modification from UniMod Chemical derivative - 5-hydro-5-methylimidazol-4-one, arginine methylglyoxal arginine adduct (+54 amu) 319#R UniMod Ref. Uchida K, Sakai K, Itakura K, Osawa T, Toyokuni S. 1977. Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins. Arch Biochem Biophys. 346(1):45-52. Delta:H(2)C(3)O(1) PSI-MS-label MDA adduct +54 UniMod-description DiffAvg 54.05 DiffFormula C 3 H 2 O 1 DiffMono 54.010565 Formula C 9 H 14 N 4 O 2 MassAvg 210.24 MassMono 210.111676 Origin R Source artifact TermSpec none MOD:00630 MOD:00902 PSI-MOD MOD:00934 Levuglandinyl - arginine hydroxylactam adduct modification from UniMod Post-translational 506 UniMod Levuglandinyl - arginine hydroxylactam adduct UniMod-description LG-Hlactam-R UniMod-interim DiffAvg 306.40 DiffFormula C 19 H 26 N -2 O 5 DiffMono 306.171876 Formula C 25 H 38 N 2 O 6 MassAvg 462.59 MassMono 462.272987 Origin R Source natural TermSpec none MOD:00846 MOD:00902 PSI-MOD MOD:00935 methionine oxidation with neutral loss of 64 Da Oxidation of methionine to methionine sulfoxide with neutral loss of CH3SOH. 18688235 PubMed 9004526 PubMed Originally created from UniMod:507 that was later deleted. DiffAvg -64.10 DiffFormula C -1 H -4 N 0 O -1 S -1 DiffMono -63.998286 Formula C 4 H 5 N 1 O 1 S 0 MassAvg 83.09 MassMono 83.037114 Origin M Source artifact TermSpec none MOD:00431 MOD:00913 PSI-MOD MOD:00936 Levuglandinyl - hydroxylactam adduct, K and N-term modification from UniMod Post-translational 504 UniMod Levuglandinyl - lysine hydroxylactam adduct UniMod-description LG-Hlactam-K UniMod-interim DiffAvg 348.44 DiffFormula C 20 H 28 O 5 DiffMono 348.193674 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00846 PSI-MOD MOD:00937 Levuglandinyl - arginine lactam adduct modification from UniMod Post-translational 505 UniMod Levuglandinyl - arginine lactam adduct UniMod-description LG-lactam-R UniMod-interim DiffAvg 290.40 DiffFormula C 19 H 26 N -2 O 4 DiffMono 290.176961 Formula C 25 H 38 N 2 O 5 MassAvg 446.59 MassMono 446.278072 Origin R Source artifact TermSpec none MOD:00846 MOD:00902 PSI-MOD MOD:00938 Levuglandinyl - lactam adduct, K and N-term modification from UniMod Post-translational 12590383 PubMed 503 UniMod Levuglandinyl - lysine lactam adduct UniMod-description LG-lactam-K UniMod-interim DiffAvg 332.44 DiffFormula C 20 H 28 O 4 DiffMono 332.198759 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00846 PSI-MOD MOD:00939 hydrolyzed N-methylmaleimide cysteine adduct modification from UniMod Chemical derivative 500 UniMod Nmethylmaleimide+water UniMod-interim Nmethylmaleimidehydrolysis UniMod-description DiffAvg 129.12 DiffFormula C 5 H 7 N 1 O 3 DiffMono 129.042593 Formula C 8 H 12 N 2 O 4 S 1 MassAvg 232.25 MassMono 232.051778 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00940 3-methyl-2-pyridyl isocyanate derivatized residue A protein modification produced by formation of an adduct with 3-methyl-2-pyridyl isocyanate. 11078590 PubMed 501 UniMod 3-methyl-2-pyridyl isocyanate UniMod-description PyMIC UniMod-interim DiffAvg 134.14 DiffFormula C 7 H 6 N 2 O 1 DiffMono 134.048013 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00840 PSI-MOD MOD:00941 dehydropyrrolizidine alkaloid (dehydroretronecine) derivatized cysteine modification from UniMod Chemical derivative 12175151 PubMed 488 UniMod Dehydropyrrolizidine alkaloid (dehydroretronecine) on cysteines UniMod-description DHP UniMod-interim DiffAvg 118.16 DiffFormula C 8 H 8 N 1 DiffMono 118.065674 Formula C 11 H 13 N 2 S 1 MassAvg 205.30 MassMono 205.079944 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:00942 (4,4,5,5-(2)H4)-L-lysine A protein modification that effectively substitutes four (1)H protium atoms with four (2)H deuterium atoms to produce (4,4,5,5-(2)H4)-L-lysine. 481 UniMod For SILAC experiments. 4,4,5,5-D4 Lysine UniMod-description 4,4,5,5-tetradeuterolysine PSI-MOD-alternate Label:2H(4) UniMod-interim lys-2H4 OMSSA-label DiffAvg 4.03 DiffFormula (1)H -4 (2)H 4 DiffMono 4.025107 Formula C 6 (1)H 8 (2)H 4 N 2 O 1 MassAvg 132.12 MassMono 132.120070 Origin K Source artifact TermSpec none MOD:00837 MOD:00912 PSI-MOD MOD:00943 4-trimethylammoniumbutanoyl derivatized residue modification from UniMod Isotopic label 12643539 PubMed 476 UniMod 4-trimethyllammoniumbutyryl- UniMod-description TMAB UniMod-interim DiffAvg 128.19 DiffFormula C 7 H 14 N 1 O 1 DiffMono 128.107539 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00944 d9-4-trimethylammoniumbutanoyl derivatized residue modification from UniMod Isotopic label 477 UniMod d9-4-trimethyllammoniumbutyryl- UniMod-description TMAB:2H(9) UniMod-interim DiffAvg 137.16 DiffFormula C 7 (1)H 5 (2)H 9 N 1 O 1 DiffMono 137.164030 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00943 MOD:01431 PSI-MOD MOD:00945 fluorescein-5-thiosemicarbazide adduct OBSOLETE because redundant and identical to MOD:00626. Remap to MOD:00626. 18688235 PubMed DiffAvg 421.43 DiffFormula C 21 H 15 N 3 O 5 S 1 DiffMono 421.073242 Formula none MassAvg none MassMono none Origin S Source artifact TermSpec none 1 PSI-MOD MOD:00946 crosslinked residues with loss of ammonia A protein modification that crosslinks two residues with a covalent bond and the loss of ammonia. 18688235 PubMed PSI-MOD-slim MOD:00033 PSI-MOD MOD:00947 DeltaMass Entries from DeltaMass see http://www.abrf.org/index.cfm/dm.home?AvgMass=all. 18688235 PubMed MOD:00032 PSI-MOD MOD:00948 5'-dephospho modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: -79 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00947 PSI-MOD MOD:00949 desmosine OBSOLETE because redundant and identical to MOD:01933. Remap to MOD:01933. 0 DeltaMass From DeltaMass: Average Mass: -58 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin K Source none TermSpec none MOD:00947 PSI-MOD MOD:00950 decomposed carboxymethylated methionine modification from DeltaMass 3 DeltaMass From DeltaMass: Average Mass: -48 Average Mass Change:-48 References:Anal. Biochem. Vol 216 No.1 p141 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin M Source none TermSpec none MOD:00947 PSI-MOD MOD:00951 L-gamma-carboxyglutamic acid with neutral loss of carbon dioxide Covalent modification of a peptide or protein L-glutamic acid residue to gamma-carboxyglutamic acid with secondary loss of a neutral carbon dioxide molecular fragment. 58 DeltaMass From DeltaMass: Average Mass: -44 Formula:CO2 Average Mass Change:-44 References:Nakamura T, Yu Z, Fainzilber M, Burlingame AL. Protein Sci (1996) 5, 524-530 Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile. Notes: The elimination of CO2 will regenerate glutamate as if there was no modification. However, peaks appearing with an interval of 44 is quite characteristic. It would be noteworthy to remind that loss of 44 from a gamma-carboxyglutamate-containing peptide may be observed not only as a result of spontaneous decarboxylation but also as an artifact under some ionization conditions such as negative ion mode MALDI. d4CbxGlu PSI-MOD-label DiffAvg -44.01 DiffFormula C -1 H 0 N 0 O -2 DiffMono -43.989829 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin E Source artifact TermSpec none MOD:00015 MOD:00906 MOD:00957 MOD:00960 PSI-MOD MOD:00952 (2-aminosuccinimidyl)acetic acid (Asp) A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the loss of a water molecule. 10801322 PubMed AA0441#ASP RESID Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue with the alpha-amido of the following residue. PSI-MOD-slim (2-aminosuccinimidyl)acetic acid RESID-name (3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid RESID-alternate [(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid RESID-systematic anhydroaspartyl glycine RESID-alternate aspartimide glycine RESID-alternate CROSSLNK (2-aminosuccinimidyl)acetic acid (Asp-Gly) UniProt-feature N-(2-aminosuccinyl)glycine RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 6 H 6 N 2 O 3 MassAvg 154.13 MassMono 154.037842 Origin D, G Source hypothetical TermSpec none MOD:00904 MOD:00954 MOD:01628 PSI-MOD MOD:00953 O-(L-isoglutamyl)-L-serine (Glu-Ser) A protein modification that effectively crosslinks an L-glutamic acid residue and an L-serine residue by an ester bond and releasing water to form O-(L-isoglutamyl)-L-serine. 0 DeltaMass 19035375 PubMed AA0597#ESX RESID Cross-link 2; From DeltaMass: with no citation. (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid RESID-systematic CROSSLNK isoglutamyl serine ester (Ser-Glu) UniProt-feature O(beta)-(gamma-glutamyl)serine RESID-alternate O-(L-isoglutamyl)-L-serine RESID-name O-gamma-Glutamyl- (Crosslink to Serine) DeltaMass-label O3-(isoglutamyl)-serine RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 8 H 10 N 2 O 4 MassAvg 198.18 MassMono 198.064057 Origin E, S Source artifact TermSpec none MOD:00906 MOD:00954 MOD:01977 PSI-MOD MOD:00954 crosslinked residues with loss of water A protein modification that crosslinks two residues with a covalent bond and the loss of water. 18688235 PubMed PSI-MOD-slim MOD:00033 PSI-MOD MOD:00955 alaninohistidine (serine crosslinked to tele or pros nitrogen of histidine) A protein modification that effectively crosslinks an L-serine residue and an L-histidine residue to release water and form tele- or pros-(2-amino-2-carboxyethyl)histidine. 0 DeltaMass Cross-link 2; From DeltaMass with no citation or formula: Average Mass: -18. The DeltaMass description "Serine crosslinked to theta or pi carbon of Histidine" is incorrect. The histidine ring nitrogens (not carbons) are designated tele or N-tau (not theta), and pros or N-pi [JSG]. beta-alaninohistidine PSI-MOD-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 9 H 10 N 4 O 2 MassAvg 206.20 MassMono 206.080376 Origin H, S Source artifact TermSpec none MOD:00909 MOD:00916 MOD:00954 PSI-MOD MOD:00956 misincorporation of norleucine for methionine modification from DeltaMass 10 DeltaMass From DeltaMass: Average Mass: -18 Average Mass Change:-18 Notes: It has the same mass as leucine or isoleucine and can be charged on the methionyl t-RNA. This often happens in minimal media-prepared fermentations that are not supplemented with enough free methionine. It gives a mass change of -18 and can often be confused with dehydration. DiffAvg -18.03 DiffFormula C 1 H 2 N 0 O 0 S -1 DiffMono -17.956421 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin M Source none TermSpec none MOD:01026 PSI-MOD MOD:00957 modified residue with neutral loss of carbon dioxide Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral carbon dioxide molecular fragment. 18688235 PubMed dCO2ModRes PSI-MOD-label DiffAvg -44.01 DiffFormula C -1 H 0 N 0 O -2 DiffMono -43.989829 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00431 PSI-MOD MOD:00958 crosslink between Arg and His sidechains modification from DeltaMass 0 DeltaMass Cross-link 2; From DeltaMass: Average Mass: -5 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin H, R Source none TermSpec none MOD:00947 PSI-MOD MOD:00959 3,3',5,5'-TerTyr (Crosslink) modification from DeltaMass 0 DeltaMass Cross-link 4; From DeltaMass: Average Mass: -4 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin Y, Y, Y, Y Source none TermSpec none MOD:00692 PSI-MOD MOD:00960 decarboxylated residue A protein modification that effectively replaces a carboxylic acid group with a hydrogen atom. 18688235 PubMed DiffAvg -44.01 DiffFormula C -1 H 0 N 0 O -2 DiffMono -43.989829 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01156 PSI-MOD MOD:00961 reduction of disulfide crosslink in cystine to two cysteines A protein modification that effectively reduces the disulfide bond of cystine to form two cysteine residues. 333 DeltaMass Cross-link 2; this modification destroys the cross-link. From DeltaMass: Treatment of cystine (cys-cys) by reducing agents such as dithiothreitol (DTT) or triscarboxyethylphosphine (TCEP) results in cleavage of the disulphide bond and reduction of the sulphur atom of each molecule to create cysteine. PSI-MOD-slim DiffAvg 2.02 DiffFormula C 0 H 2 N 0 O 0 S 0 DiffMono 2.015650 Formula C 6 H 10 N 2 O 2 S 2 MassAvg 206.28 MassMono 206.018370 Origin MOD:00034 Source none TermSpec none MOD:00905 MOD:01473 derives_from MOD:000340 PSI-MOD MOD:00962 2',3'-dihydrotryptophan A protein modification that by reducing the indole ring system of tryptophan to indoline effectively converts an L-tryptophan residue to 2',3'-dihydrotryptophan. 343 DeltaMass From DeltaMass: References:1. Pearson,D.A., Blanchette,M., Baker,M.L. and Guindon,C.A. (1989) Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking ofprotecting groups in peptide synthesis. Tetrahedron Lett., 30(21), 2739-2742 Notes: Reduction of indole double bond of Trp which occurs when triethylsilane (TES) is used as a scavenger and Trp is incorporated without protection of indole nitrogen [1]. This side reaction is likely to be accompanied by oxidation of indoline ring with formation of intensively colored peptide by-products. Triisopropylsilane (TIPS) does not give this side reaction. See structure at http://www.abrf.org/images/misc/dmass2.gif. [However, the pictured indoline structure is incorrect - JSG]. DiffAvg 2.02 DiffFormula C 0 H 2 N 0 O 0 S 0 DiffMono 2.015650 Formula C 11 H 12 N 2 O 1 MassAvg 188.23 MassMono 188.094963 Origin W Source artifact TermSpec none MOD:00918 MOD:01473 PSI-MOD MOD:00963 Oxidation of Trp to kynurenine Modification from DeltaMass. OBSOLETE because redundant and identical to MOD:00462. Remap to MOD:00462. 357 DeltaMass From DeltaMass: Average Mass: 4 Monoisotopic Mass Change:3.995 Average Mass Change:3.989 References:Ruoppolo M, Amoresano A, Pucci P, Pascarella S, Polticelli F, Trovato M,Menegatti E, Ascenzi P.Characterization of five new low-molecular-mass trypsin inhibitors fromwhite mustard (Sinapis alba L.) seed.Eur J Biochem. 2000 267:6486-92. Notes: See structure at http://www.abrf.org/images/misc/dmass32.jpg. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin W Source artifact TermSpec none 1 PSI-MOD MOD:00964 lysine epsilon amino to imine + 12 amu modification from DeltaMass 34 DeltaMass From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Mathews, W. Rodney; Runge, Thomas A.; Haroldsen, Peter E.; Gaskell, Simon J. (1989) Characterization of impurities in a synthetic renin substrate peptide by fast-atom bombardment mass spectrometry and hybrid tandem mass spectrometry. Rapid Commun. Mass Spectrom. 3(9), 314-19 Notes: Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side products, including a component 12 Da higher in mass. Low-energy collisionally activated ***decompn*** analyses were performed using a hybrid tandem instrument and demonstrated that the heavier side product had two components, in which the structural modification was either at the N- or the C-terminus. Addnl. analyses of the N-acetyl deriv. indicated that for each component the structural modification blocked a site of N-acetylation. It is suggested that the formation of these side products is attributable to the generation of formaldehyde, during removal of the histidine protecting group (benzyloxymethyl), which reacts with the N-terminus of the peptide to give an imidazolidinone structure or with the D- ***lysine***.epsilon.-amine group to yield an ***imine*** . While the precise genesis of the side-products remains speculative, it is clear that the combined strategy of derivatization and tandem mass spectrometry has allowed structural conclusions concerning individual components of an isobaric mixt. N6-(methylidene)-lysine PSI-MOD-alternate DiffAvg 12.01 DiffFormula C 1 H 0 N 0 O 0 DiffMono 12.000000 Formula C 7 H 12 N 2 O 1 MassAvg 140.19 MassMono 140.094963 Origin K Source artifact TermSpec none MOD:00947 PSI-MOD MOD:00965 4-thiazolidinecarboxylic acid A protein modification that effectively converts an N-terminal L-cysteine residue by a formadehyde adduct to 4-thiazolidinecarboxylic acid. 342 DeltaMass From DeltaMass: References: Mitchell, M.A., Runge, T.A., Mathews, W.R., Ichhpurani, A.K., Harn, N.K., Dobrowolski, P.J. and Eckenrrrode, F.M. Problems associated with use of the benzylozymethyl protecting group for histidines. Formaldehyde adducts formed during cleavage by hydrogen fluoride. Int. J. Pept. Protein Res. 1990, 36(4), 350-355. Gesquiere, J.-C., Diesis, E. and Tartar, A. Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deprotection of peptides containing pi-N-Bom protected histidine. J. Chem. Soc. Chem. Commun. 1990, (20), 1402-1403. Kumagaye, K.Y., Inui, T., Nakajima, K., Kimura,T. and Sakakibara, S. Suppression of a side reaction associated with Nim-benzyloxymethyl group during synthesis of peptides containing cysteinyl residue at the N-terminus. Pept. Res. 1991, 4(2), 84-87. Colombo, R., Colombo, F. and Jones, J.H. Acid-labile histidine side-chain protection. The N(pi)-t-butoxymethyl group. J. Chem. Soc. Chem. Commun. 1984, (5), 292-293. Notes: Conversion of N-term Cys to thiazolidine during HF deprotection of His(Bom)-containing peptides [1-3]. See structure at http://www.abrf.org/images/misc/dmass12b.gif; modification in red. This modification cannot be excluded during final deprotection/cleavage in Fmoc-chemistry in cases when His(Bum) was employed [4]. For formation of free imino acid see PubMed:1527501. thioproline DeltaMass-label DiffAvg 12.01 DiffFormula C 1 H 0 N 0 O 0 S 0 DiffMono 12.000000 Formula C 4 H 6 N 1 O 1 S 1 MassAvg 116.16 MassMono 116.017010 Origin C Source artifact TermSpec N-term MOD:00905 PSI-MOD MOD:00966 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid A protein modification that effectively converts an N-terminal L-tryptophan residue by a formadehyde adduct to 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. 339 DeltaMass From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Lippke, K. P., W. G. Schunack, W. Wenning, W. E. Mueller. 1983..beta.-Carbolines as benzodiazepine receptor ligands. 1. Synthesis andbenzodiazepine receptor interaction of esters of.beta.-carboline-3-carboxylic acid. J. Med. Chem.26: 499-503 Cain, M., R. W. Weber, F. Guzman, J. M. Cook, S. A. Barker, K. C.Rice, J. N. Crawley, S. M. Paul, P. Skolnick. 1982. .beta.-Carbolines:synthesis and neurochemical and pharmacological actions on brainbenzodiazepine receptors.J. Med. Chem. 25: 1081-91 Notes: +12 Da modification corresponds to formaldehyde adduct of Trp having beta-carboline structure (methylene bridge links carbon-2 of indole ring and alfa-N. See structure at http://www.abrf.org/images/misc/dmass12a.gif; modification in red. DiffAvg 12.01 DiffFormula C 1 H 0 N 0 O 0 S 0 DiffMono 12.000000 Formula C 12 H 10 N 2 O 1 MassAvg 198.22 MassMono 198.079313 Origin W Source artifact TermSpec none MOD:00918 PSI-MOD MOD:00967 syndesine A protein modification that effectively cross-links two L-lysine residues to form syndesine, hydroxylysinohydroxynorleucine. 35 DeltaMass 75151974 PubMed Cross-link 2; From DeltaMass: Average Mass: 13 Average Mass Change: 13 (incorrect) [JSG]. hydroxylysinohydroxynorleucine PSI-MOD-alternate DiffAvg 16.96 DiffFormula C 0 H -3 N -2 O 3 DiffMono 16.955121 Formula C 12 H 21 N 2 O 5 MassAvg 273.31 MassMono 273.145047 Origin K, K Source none TermSpec none MOD:00947 PSI-MOD MOD:00968 CM-Cys vs PAM-Cys modification from DeltaMass 347 DeltaMass From DeltaMass: Average Mass: 13 Formula:C2H2O2 vs C3H5ON Monoisotopic Mass Change:13.03 Average Mass Change:13.05 Notes:Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetic acid e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxymethyl-Cys (CM-Cys, DeltaMass +58Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 13Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none MOD:00947 PSI-MOD MOD:00969 CAM-Cys vs PAM-Cys modification from DeltaMass 346 DeltaMass From DeltaMass: Average Mass: 14 Formula:CH2 Monoisotopic Mass Change:14.016 Average Mass Change:14.027 Notes: Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetamide e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxamidomethyl-Cys (CAM-Cys, DeltaMass +57Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 14Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none MOD:00947 PSI-MOD MOD:00970 delta-hydroxy-allysine (Lys) modification from DeltaMass 37 DeltaMass From DeltaMass: Average Mass: 15 Average Mass Change:15 Notes:In going from Lys to hydroxy-allysine, two separate reactions are involved:1. the oxidative deamination converting Lys to allysine (-CH2NH2 being converted to -CHO) with a net mass change of -1;2.conversion of allysine to delta-hydroxy-allysine (-CH2-CHO being converted to -CH(OH)-CHO) with a mass change of +16. The net change from Lys to hydroxyallysine thus is +15. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin K Source natural TermSpec none MOD:00947 PSI-MOD MOD:00971 Oxohistidine (from histidine) modification from DeltaMass 38 DeltaMass From DeltaMass: Average Mass: 16 Average Mass Change:16 References:Lewisch, S. A. and Levine, R. L. (1995) Anal. Biochem. 231, 440-446. Determination of 2-oxo-histidine by amino acid analysis Notes:Rod LevineNIHBldg 3, Room 106 MSC 0320Bethesda, MD 20892-0320email: rlevine@nih.govvoice: 1 (301) 496-2310fax: 1 (301) 496-0599 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin H Source none TermSpec none MOD:00947 PSI-MOD MOD:00972 monobrominated L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to a monobrominated L-phenylalanine, such as L-2'-bromophenylalanine. 340#F UniMod From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa Br1Phe PSI-MOD-label bromination UniMod-description Bromo PSI-MS-label DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910512 Formula Br 1 C 9 H 8 N 1 O 1 MassAvg 226.07 MassMono 224.978926 Origin F Source natural TermSpec none MOD:01066 MOD:01912 PSI-MOD MOD:00973 Oxidation of proline (to glutamic acid) modification from DeltaMass 355 DeltaMass From DeltaMass: Average Mass: 32 Monoisotopic Mass Change:31.99 Average Mass Change:32 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Rod Levine (unpublished) DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin P Source artifact TermSpec none MOD:00947 PSI-MOD MOD:00974 (35)Cl labeled 3'-chlorotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 34 DiffAvg 33.96 DiffFormula (35)Cl 1 H -1 DiffMono 33.961028 Formula C 9 (35)Cl 1 H 8 N 1 O 2 MassAvg 197.02 MassMono 197.024356 Origin Y Source artifact TermSpec none MOD:01046 PSI-MOD MOD:00975 (37)Cl labeled 3'-chlorotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 36 DiffAvg 35.96 DiffFormula (37)Cl 1 H -1 DiffMono 35.958078 Formula C 9 (37)Cl 1 H 8 N 1 O 2 MassAvg 199.02 MassMono 199.021406 Origin Y Source artifact TermSpec none MOD:01046 PSI-MOD MOD:00976 potassium salt modification from DeltaMass - OBSOLETE because redundant and identical to MOD:01072. Remap to MOD:01072. 0 DeltaMass From DeltaMass: Average Mass: 38 DiffAvg 38.09 DiffFormula H -1 K 1 DiffMono 37.955882 Formula none MassAvg none MassMono none Origin X Source none TermSpec none 1 PSI-MOD MOD:00977 disodium salt modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 44 PSI-MOD-slim DiffAvg 43.96 DiffFormula H -2 Na 2 DiffMono 43.963888 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00747 PSI-MOD MOD:00978 piperidine adduct to C-terminal Cys modification from DeltaMass 345 DeltaMass From DeltaMass: Average Mass: 51 Average Mass Change: 51 References:Lukszo, Patterson, Albericio, and Kates, Letters in Peptide Science 3, 157-166(1996) Notes:The side reaction can be very significant, and the level to which it occurs depends on how the C-terminal Cys is anchored and what the side-chain protecting group is. The mechanism involves piperidine-mediated beta-elimination of sulfur (with the protecting group on), followed by addition of piperidine across the C-terminaldehydroalanine. Since this last-mentioned step creates a chiral center, a mixture of diastereomers is formed which in special cases can be separatedby HPLC. Another problem with C-terminal Cys is racemization; some references in the review article by Andreu, Albericio, Sole, Munson, Ferrer, and Barany in Pennington-Dunn Peptide Synthesis and Purification Protocols, vol 35, 1994, pp. 91-169. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none MOD:00947 PSI-MOD MOD:00979 t-butyl ester (OtBu) and t-butyl (tBu) modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 56 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:00980 Carboxamidomethyl (on Cysteine) modification from DeltaMass - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060. 337 DeltaMass From DeltaMass: Average Mass: 57 Abbreviation:CamCys Formula:C2H3NO Monoisotopic Mass Change:57.021 Average Mass Change:57.051 Notes:Cysteine reacts with iodoacetamide to produce carboxamidomethyl cysteine. Alternative names are often used, such as amidocarboxymethylcysteine and carbamoylmethylcysteine DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none 1 PSI-MOD MOD:00981 sodium and potassium salt modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 60 PSI-MOD-slim DiffAvg 60.07 DiffFormula H -2 K 1 Na 1 DiffMono 59.937826 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00747 MOD:00849 PSI-MOD MOD:00982 L-selenocysteine (Ser) A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process). 0 DeltaMass [From DeltaMass: Average Mass: 64.] Although selenocysteine-charged tRNA(Sec) is biosynthesized from serine-charged tRNA(Sec), in peptide work selenocysteine is usually considered as either a natural residue or as a modified cysteine residue. This entry is for the artifactual formation of L-selenocysteine from serine. For encoded L-selenocysteine, use MOD:00031 [JSG]. Sec(Ser) PSI-MOD-label Selenocysteine (from Serine) DeltaMass-label DiffAvg 62.97 DiffFormula C 0 H 0 N 0 O -1 Se 1 DiffMono 63.921607 Formula C 3 H 5 N 1 O 1 Se 1 MassAvg 150.05 MassMono 150.953635 Origin S Source artifact TermSpec none MOD:00031 MOD:00916 PSI-MOD MOD:00983 Asp transamidation with piperidine modification from DeltaMass 67 DeltaMass From DeltaMass: Average Mass: 67 Average Mass Change:67 References:http://www.abrf.org/archives/hmail/0008/0007.html Notes:1.) Get rid of the DBU. It can cause piperidine amides at Asp residues. The tbu ester side chain comes off during synthesis and the residue is trans-amidated with piperidine (+67Da by MS). If you haven't yet seen this, you will. Even "normal" 20% pip/DMF (NMP) will cause this, but less frequently. Literature exists for this; I don't remember the exact reference. David H. Singleton Scientist Pfizer Central Research PO Box 8118-101 Eastern Point Road Groton, CT 06340 (860)441-4404. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin D Source artifact TermSpec none MOD:00947 PSI-MOD MOD:00984 (35)Cl labeled 3',5'-dichlorotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 68 DiffAvg 67.92 DiffFormula (35)Cl 2 H -2 DiffMono 67.922055 Formula C 9 (35)Cl 2 H 7 N 1 O 2 MassAvg 230.99 MassMono 230.985384 Origin Y Source artifact TermSpec none MOD:01045 PSI-MOD MOD:00985 halogenated tyrosine A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a halogen atom. 18688235 PubMed PSI-MOD-slim HalTyr PSI-MOD-label Origin Y Source none TermSpec none MOD:00694 MOD:00919 PSI-MOD MOD:00986 (35)Cl and (37)Cl labeled 3',5'-dichlorotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 70. DiffAvg 69.92 DiffFormula (35)Cl 1 (37)Cl 1 H -2 DiffMono 69.919105 Formula C 9 (35)Cl 1 (37)Cl 1 H 7 N 1 O 2 MassAvg 232.98 MassMono 232.982434 Origin Y Source artifact TermSpec none MOD:01045 PSI-MOD MOD:00987 chlorinated tyrosine A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a chlorine atom. 18688235 PubMed ClTyr PSI-MOD-label Origin Y Source none TermSpec none MOD:00753 MOD:00985 PSI-MOD MOD:00988 brominated tyrosine A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a bromine atom. 18688235 PubMed BrTyr PSI-MOD-label Origin Y Source none TermSpec none MOD:00754 MOD:00985 PSI-MOD MOD:00989 acetamidomethyl (Acm) OBSOLETE because redundant, the difference component of MOD:01079. Remap to MOD:01079. 0 DeltaMass From DeltaMass with no citation or formula. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none 1 PSI-MOD MOD:00990 (37)Cl labeled 3',5'-dichlorotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 72 DiffAvg 71.92 DiffFormula (37)Cl 2 H -2 DiffMono 71.916155 Formula C 9 (37)Cl 2 H 7 N 1 O 2 MassAvg 234.98 MassMono 234.979484 Origin Y Source artifact TermSpec none MOD:01045 PSI-MOD MOD:00991 S-(sn-1-glyceryl)-L-cysteine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 74 with no citation. DiffAvg 74.08 DiffFormula C 3 H 6 O 2 DiffMono 74.036779 Formula C 6 H 11 N 1 O 3 S 1 MassAvg 177.22 MassMono 177.045964 Origin C Source artifact TermSpec none MOD:00947 PSI-MOD MOD:00992 glutamate 5-glycerol ester modification from DeltaMass 78 DeltaMass 18767873 PubMed From DeltaMass: Average Mass: 74 Average Mass Change: 74 References: Anal. Biochem. 1993 Vol 208 No. 2 382-386, PubMed:8452236. [DeltaMass] This article only suggests this as a possible modification and does no characterization. Isolation and stuctural evidence for artifactual modification are found in PubMed:18767873 [JSG]. DiffAvg 74.08 DiffFormula C 3 H 6 O 2 DiffMono 74.036779 Formula C 8 H 13 N 1 O 5 MassAvg 203.19 MassMono 203.079373 Origin E Source artifact TermSpec none MOD:00906 PSI-MOD MOD:00993 phenyl ester modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 76, on acidic amino acids OPh DeltaMass-label DiffAvg 76.10 DiffFormula C 6 H 4 DiffMono 76.031300 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00994 (79)Br labeled 3'-bromotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 78 DiffAvg 77.91 DiffFormula (79)Br 1 H -1 DiffMono 77.910512 Formula (79)Br 1 C 9 H 8 N 1 O 2 MassAvg 240.97 MassMono 240.973841 Origin Y Source artifact TermSpec none MOD:01025 PSI-MOD MOD:00995 (81)Br labeled 2'-bromophenylalanine A protein modification that effectively converts an L-phenylalanine residue to (81)Br-L-2'-bromophenylalanine. 0 DeltaMass From DeltaMass: Average Mass: 80 DiffAvg 79.91 DiffFormula (81)Br 1 H -1 DiffMono 79.908466 Formula (81)Br 1 C 9 H 8 N 1 O 1 MassAvg 226.98 MassMono 226.976879 Origin F Source artifact TermSpec none MOD:00183 PSI-MOD MOD:00996 (81)Br labeled 3'-bromotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 80 DiffAvg 79.91 DiffFormula (81)Br 1 H -1 DiffMono 79.908466 Formula (81)Br 1 C 9 H 8 N 1 O 2 MassAvg 242.97 MassMono 242.971794 Origin Y Source artifact TermSpec none MOD:01025 PSI-MOD MOD:00997 cyclohexyl ester modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 82 OcHex DeltaMass-label DiffAvg 82.15 DiffFormula C 6 H 10 DiffMono 82.078250 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:00998 iodinated tyrosine A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with an iodine atom. 18688235 PubMed PSI-MOD-slim ITyr PSI-MOD-label Origin Y Source none TermSpec none MOD:00755 MOD:00985 PSI-MOD MOD:00999 homoseryl lactone OBSOLETE because redundant and identical to MOD:00404. Remap to MOD:00404. 90 DeltaMass From DeltaMass: Average Mass: 83 Formula:C4H5O1N1 Monoisotopic Mass Change:83.037 Average Mass Change:83.09 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin M Source artifact TermSpec none 1 PSI-MOD MOD:01000 monobrominated tyrosine A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one bromine atom. 18688235 PubMed Br1Tyr PSI-MOD-label Origin Y Source none TermSpec none MOD:00988 PSI-MOD MOD:01001 2-aminoisobutyric acid residue (Aib) A protein modification that inserts or replaces a residue with a 2-aminoisobutyric acid. 0 DeltaMass Modification from DeltaMass: Average Mass: 85. 2-amino-2-methylpropanoic acid PSI-MOD-alternate 2-amino-2-methylpropionic acid PSI-MOD-alternate 2-methylalanine PSI-MOD-alternate Aib PSI-MOD-alternate alpha,alpha-dimethylglycine PSI-MOD-alternate alpha-aminoisobutyric acid PSI-MOD-alternate alpha-methylalanine PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula C 4 H 7 N 1 O 1 MassAvg 85.11 MassMono 85.052764 Origin X Source artifact TermSpec none MOD:00850 PSI-MOD MOD:01002 gamma-aminobutyryl modification from DeltaMass 92 DeltaMass From DeltaMass: Average Mass: 85 Formula: C 4 H 7 O 1 N 1 Monoisotopic Mass Change: 85.053 Average Mass Change: 85.106 DiffAvg 85.11 DiffFormula C 4 H 7 N 1 O 1 DiffMono 85.052764 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01003 t-butyloxymethyl (Bum) modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 86 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01004 diaminopropionyl modification from DeltaMass 95 DeltaMass From DeltaMass: Average Mass: 86 Formula: C 3 H 6 O 2 N 1 Monoisotopic Mass Change: 86.048 Average Mass Change: 86.094 DiffAvg 86.09 DiffFormula C 3 H 6 N 2 O 1 DiffMono 86.048013 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01005 t-butylsulfenyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 88 StBu DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01006 dibrominated tyrosine A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two bromine atoms. 534 UniMod Br2Tyr PSI-MOD-label Dibromo PSI-MS-label Dibromo UniMod-description DiffAvg 157.79 DiffFormula Br 2 C 0 H -2 N 0 O 0 DiffMono 155.821024 Formula Br 2 C 9 H 7 N 1 O 2 MassAvg 320.97 MassMono 318.884353 Origin Y Source none TermSpec none MOD:00988 PSI-MOD MOD:01007 anisyl modified residue A protein modification that effectively substitutes an anisyl (methoxyphenyl) group for a hydroxyl group, typically at the 4 or para position. 0 DeltaMass From DeltaMass with no citation or formula: Average Mass: 90. DiffAvg 90.13 DiffFormula C 7 H 6 DiffMono 90.046950 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01008 benzyl (Bzl) and benzyl ester (OBzl) modified residue A protein modification that effectively substitutes a benzyl (phenylmethyl) group for a hydrogen atom. 0 DeltaMass From DeltaMass with no citation or formula: Average Mass: 90 DiffAvg 90.13 DiffFormula C 7 H 6 DiffMono 90.046950 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01009 dehydrogenated proline modification from DeltaMass 0 DeltaMass From DeltaMass with no citation. DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 5 H 5 N 1 O 1 MassAvg 95.10 MassMono 95.037114 Origin P Source none TermSpec none MOD:00915 MOD:01888 PSI-MOD MOD:01010 trifluoroacetylated residue A protein modification that effectively substitutes a trifluoroacetyl group for a hydrogen atom. 0 DeltaMass TFA DeltaMass-label DiffAvg 96.01 DiffFormula C 2 F 3 H -1 O 1 DiffMono 95.982299 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00498 MOD:00649 MOD:00848 PSI-MOD MOD:01011 N-hydroxysuccinimide (ONSu, OSu) modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 97 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01012 oxidation of disulfide crosslink in cystine to two cysteic acids A protein modification that effectively oxidizes the disulfide bond of a cystine crosslink to form two cysteic acid residues. 335 DeltaMass Cross-link 2. This modification destroys a cross-link. From DeltaMass: Average Mass: 98 Abbreviation: Cya Average Mass Change: 98 Notes: Treatment of cystine by strongly oxidising reagents such as performic acid results in the breakage of the disulphide bond and complete oxidation of the sulphur atoms on each molecule. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. DiffAvg 98.01 DiffFormula C 0 H 2 N 0 O 6 S 0 DiffMono 97.985138 Formula C 6 H 10 N 2 O 8 S 2 MassAvg 302.27 MassMono 301.987857 Origin MOD:00034 Source artifact TermSpec none MOD:00460 derives_from MOD:000340 PSI-MOD MOD:01013 tetramethylguanidinium termination by-product on amine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 98 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00947 PSI-MOD MOD:01014 phosphate/sulphate adduct of proteins modification from DeltaMass 358 DeltaMass From DeltaMass: Average Mass: 98 Formula:H3PO4 or H2SO4 Monoisotopic Mass Change:97.97 Average Mass Change:98 Notes:Proteins may pick up non-covalent salt adducts during purification. Phosphate and sulphate salts are commonly used and may be observed as +98 amu adducts (or multiples thereof) forming ion pairs with basic residues. Monoisotopic masses H2SO4 97.967, H3PO4 97.977 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00947 PSI-MOD MOD:01015 isovaline residue (Iva) A protein modification that inserts or replaces a residue with an isovaline. 110 DeltaMass 2-amino-2-methylbutanoic acid PSI-MOD-alternate Isovalyl (-I-,-Iva-) DeltaMass-label Iva PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula C 5 H 9 N 1 O 1 MassAvg 99.13 MassMono 99.068414 Origin X Source artifact TermSpec none MOD:00850 PSI-MOD MOD:01016 t-butyloxycarbonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 100 tBoc DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01017 homoseryl (-Hse-) OBSOLETE because redundant and identical to MOD:00403. Remap to MOD:00403. 113 DeltaMass From DeltaMass: Average Mass: 101 Abbreviation:-Hse- Formula:C4H7O2N Monoisotopic Mass Change:101.048 Average Mass Change:101.105 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin M Source artifact TermSpec none 1 PSI-MOD MOD:01018 4-methylbenzyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 104 Meb DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01019 hydroxymethylphenyl linker modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 106 HMP DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01020 thioanisyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 106 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01021 thiocresyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 106 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01022 2-piperidinecarboxylic acid A protein modification that effectively converts an L-lysine residue to 2-piperidinecarboxylic acid. 0 DeltaMass Pip DeltaMass-label DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 6 H 9 N 1 O 1 MassAvg 111.14 MassMono 111.068414 Origin K Source artifact TermSpec none MOD:00601 MOD:00912 MOD:01160 PSI-MOD MOD:01023 3',5'-dibromo-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to 3',5'-dibromo-L-tyrosine. 156 DeltaMass 3',5'-Br2Tyr PSI-MOD-label DiffAvg 157.79 DiffFormula Br 2 C 0 H -2 N 0 O 0 DiffMono 155.821024 Formula Br 2 C 9 H 7 N 1 O 2 MassAvg 320.97 MassMono 318.884353 Origin Y Source none TermSpec none MOD:01006 PSI-MOD MOD:01024 monohydroxylated proline A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline. 0 DeltaMass 35#P UniMod From DeltaMass: Average Mass: 131. This is the mass of the free amino acid [JSG]. PSI-MOD-slim Hy1Pro PSI-MOD-label hydroxylationp OMSSA-label Hydroxyproline DeltaMass-label Hyp DeltaMass-label Oxidation PSI-MS-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 7 N 1 O 2 MassAvg 113.12 MassMono 113.047678 Origin P Source natural TermSpec none MOD:00425 MOD:00594 MOD:00678 PSI-MOD MOD:01025 3'-bromo-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to 3'-bromo-L-tyrosine. 18688235 PubMed 3'-BrTyr PSI-MOD-label DiffAvg 78.90 DiffFormula Br 1 H -1 DiffMono 77.910512 Formula Br 1 C 9 H 8 N 1 O 2 MassAvg 242.07 MassMono 240.973841 Origin Y Source none TermSpec none MOD:01000 PSI-MOD MOD:01026 norleucine residue (Nle) A protein modification that inserts or replaces a residue with a norleucine. 126 DeltaMass Nle DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin X Source artifact TermSpec none MOD:00850 PSI-MOD MOD:01027 t-amyloxycarbonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 114 Aoc DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01028 monochlorinated L-tyrosine A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one chlorine atom. 18688235 PubMed Cl1Tyr PSI-MOD-label DiffAvg 34.44 DiffFormula C 0 Cl 1 H -1 N 0 O 0 DiffMono 33.961028 Formula C 9 Cl 1 H 8 N 1 O 2 MassAvg 197.62 MassMono 197.024356 Origin Y Source artifact TermSpec none MOD:00987 MOD:01911 PSI-MOD MOD:01029 succinylated residue A protein modification that effectively replaces a hydrogen atom with a succinyl group linked through a carbonyl carbon. 0 DeltaMass 64 UniMod From DeltaMass with no citation or formula, Average Mass: 117 [JSG]. PSI-MOD-slim Succinic anhydride labeling reagent light form (N-term & K) UniMod-description DiffAvg 100.07 DiffFormula C 4 H 4 O 3 DiffMono 100.016044 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00649 PSI-MOD MOD:01030 hydroxybenzotriazole ester modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 117 HOBt DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01031 dimethylbenzyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 118 diMeBzl DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01032 benzyloxymethyl modified residue A protein modification that effectively substitutes a benzyloxymethyl group for a hydrogen atom. 0 DeltaMass Bom DeltaMass-label DiffAvg 120.15 DiffFormula C 8 H 8 O 1 DiffMono 120.057515 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01033 p-methoxybenzyl modified residue A protein modification that effectively substitutes a p-methoxybenzyl group for a hydrogen atom. 0 DeltaMass Mbzl DeltaMass-label Mob DeltaMass-label DiffAvg 120.15 DiffFormula C 8 H 8 O 1 DiffMono 120.057515 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01034 4-nitrophenyl modified residue A protein modification that effectively substitutes a 4-nitrophenyl group for a hydrogen atom. 0 DeltaMass ONp DeltaMass-label p-nitrophenyl DeltaMass-label DiffAvg 121.10 DiffFormula C 6 H 3 N 1 O 2 DiffMono 121.016378 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01035 chlorobenzyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 125 ClBzl DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01036 O-methyl aspartyl OBSOLETE because redundant and identical to MOD:01181. Remap to MOD:01181. 18688235 PubMed From DeltaMass:148 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 129 Formula: C5H7O1N3 Monoisotopic Mass Change: 129.042 Average Mass Change: 129.116 DiffAvg none DiffFormula none DiffMono none Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin D Source none TermSpec none 1 PSI-MOD MOD:01037 dichlorinated tyrosine A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two chlorine atoms. 18688235 PubMed Cl2Tyr PSI-MOD-label DiffAvg 68.88 DiffFormula C 0 Cl 2 H -2 N 0 O 0 DiffMono 67.922055 Formula C 9 Cl 2 H 7 N 1 O 2 MassAvg 232.06 MassMono 230.985384 Origin Y Source artifact TermSpec none MOD:00987 PSI-MOD MOD:01038 norleucine (Nle) OBSOLETE because this represents a free amino acid and the corresponding residue is MOD:01026. 0 DeltaMass From DeltaMass: Average Mass: 131. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none 1 PSI-MOD MOD:01039 hydroxy aspartyl OBSOLETE because redundant and identical to MOD:00036. Remap to MOD:00036. 18688235 PubMed From DeltaMass:152 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 131 Formula:C4H5O1N4 Monoisotopic Mass Change:131.022 Average Mass Change:131.088 DiffAvg none DiffFormula none DiffMono none Formula C 4 H 5 N 1 O 4 MassAvg 131.09 MassMono 131.021858 Origin D Source none TermSpec none 1 PSI-MOD MOD:01040 penicillamine residue A protein modification that inserts or replaces a residue with a penicillamine. 154 DeltaMass From DeltaMass: Name misspelled 'bb-dimethyl cystenyl'. No citation provided. 2-amino-3-mercapto-3-methylbutanoic acid PSI-MOD-alternate 2-amino-3-methyl-3-sulfanylbutanoic acid PSI-MOD-alternate 3,3-dimethylcysteine PSI-MOD-alternate 3-mercapto-L-valine PSI-MOD-alternate beta,beta-dimethylcysteine DeltaMass-label Pen DeltaMass-label Pen PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula C 5 H 9 N 1 O 1 S 1 MassAvg 131.19 MassMono 131.040485 Origin X Source artifact TermSpec none MOD:00850 PSI-MOD MOD:01041 benzyloxycarbonyl modified residue A protein modification that effectively substitutes a benzyloxycarbonyl group for a hydrogen atom. 0 DeltaMass Z DeltaMass-label DiffAvg 134.13 DiffFormula C 8 H 6 O 2 DiffMono 134.036779 Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01042 adamantyl modified residue A protein modification that effectively substitutes a adamantyl group for a hydrogen atom. 0 DeltaMass Ada DeltaMass-label DiffAvg 134.22 DiffFormula C 10 H 14 DiffMono 134.109550 Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01043 p-nitrobenzyl ester modified residue A protein modification that effectively substitutes a p-nitrobenzyl group for the hydrogen atom of a carboxyl group. 0 DeltaMass ONb DeltaMass-label DiffAvg 135.12 DiffFormula C 7 H 5 N 1 O 2 DiffMono 135.032028 Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01044 N-methyl glutamyl OBSOLETE because redundant and identical to MOD:00080. Remap to MOD:00080. 166 DeltaMass From DeltaMass with no citation. Formula:C6H10O2N2 (name misspelled, formula for N5-methylglutaminyl, rather than N2-methylglutamyl) DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin Q Source none TermSpec none 1 PSI-MOD MOD:01045 3',5'-dichloro-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to 3',5'-dichloro-L-tyrosine. 18688235 PubMed 3',5'-Cl2Tyr PSI-MOD-label DiffAvg 68.88 DiffFormula C 0 Cl 2 H -2 N 0 O 0 DiffMono 67.922055 Formula C 9 Cl 2 H 7 N 1 O 2 MassAvg 232.06 MassMono 230.985384 Origin Y Source artifact TermSpec none MOD:01037 PSI-MOD MOD:01046 3'-chloro-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to 3'-chloro-L-tyrosine. 18688235 PubMed 3'-ClTyr PSI-MOD-label DiffAvg 34.44 DiffFormula C 0 Cl 1 H -1 N 0 O 0 DiffMono 33.961028 Formula C 9 Cl 1 H 8 N 1 O 2 MassAvg 197.62 MassMono 197.024356 Origin Y Source artifact TermSpec none MOD:01028 PSI-MOD MOD:01047 monohydroxylated lysine A protein modification that effectively converts an L-lysine residue to a monohydroxylated lysine. 168 DeltaMass 35#K UniMod From DeltaMass: Average Mass: 144 Abbreviation:-Hyl- Formula:C6H12N2O2 Monoisotopic Mass Change:144.09 Average Mass Change:144.174. PSI-MOD-slim Hy1Lys PSI-MOD-label Hydroxy Lysyl (-Hyl-) DeltaMass-label hydroxylationk OMSSA-label Oxidation PSI-MS-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 12 N 2 O 2 MassAvg 144.17 MassMono 144.089878 Origin K Source natural TermSpec none MOD:00425 MOD:00681 PSI-MOD MOD:01048 2-pyrrolidone-5-carboxylic acid A protein modification that effectively converts a source amino acid residue to 2-pyrrolidone-5-carboxylic acid. 18688235 PubMed From DeltaMass: Average Mass: -18 Average Mass Change: -18.01 References:The conversion of glutamic acid to pyroglutamic was reported for the beta-amiloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52. PSI-MOD-slim PyrGlu PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula C 5 H 6 N 1 O 2 MassAvg 112.11 MassMono 112.039853 Origin X Source none TermSpec N-term MOD:00601 MOD:00859 PSI-MOD MOD:01049 halogenated histidine A protein modification that effectively substitutes a hydrogen atom of an L-histidine residue with a halogen atom. 18688235 PubMed HalHis PSI-MOD-label Origin H Source none TermSpec none MOD:00694 MOD:00909 PSI-MOD MOD:01050 pyridyl alanyl modification from DeltaMass 180 DeltaMass From DeltaMass: Average Mass: 148 Formula:C8H8O2N1 Monoisotopic Mass Change:148.064 Average Mass Change:148.165 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin A Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01051 2-nitrobenzoyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 149 NBz DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01052 dimethoxybenzyl Trp modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 150 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin W Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01053 2-nitrophenylsulphenyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 153 Nps DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01054 4-toluenesulfonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 154 4-toluenesulphonyl DeltaMass-label Tos DeltaMass-label Tosyl DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01055 3-nitro-2-pyridinesulfenyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 154 Npys DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01056 (79)Br labeled 3',5'-dibromotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 156 DiffAvg 155.82 DiffFormula (79)Br 2 C 0 H -2 N 0 O 0 DiffMono 155.821024 Formula (79)Br 2 C 9 H 7 N 1 O 2 MassAvg 318.88 MassMono 318.884353 Origin Y Source artifact TermSpec none MOD:01023 PSI-MOD MOD:01057 (79)Br and (81)Br labeled 3',5'-dibromotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 158 DiffAvg 157.82 DiffFormula (79)Br 1 (81)Br 1 C 0 H -2 N 0 O 0 DiffMono 157.818978 Formula (79)Br 1 (81)Br 1 C 9 H 7 N 1 O 2 MassAvg 320.88 MassMono 320.882306 Origin Y Source artifact TermSpec none MOD:01023 PSI-MOD MOD:01058 dichlorobenzyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 159 Dcb DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01059 (81)Br labeled 3',5'-dibromotyrosine modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 160 DiffAvg 159.82 DiffFormula (81)Br 2 C 0 H -2 N 0 O 0 DiffMono 159.816931 Formula (81)Br 2 C 9 H 7 N 1 O 2 MassAvg 322.88 MassMono 322.880260 Origin Y Source artifact TermSpec none MOD:01023 PSI-MOD MOD:01060 S-carboxamidomethyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine. 196 DeltaMass 337 DeltaMass 10504701 PubMed 11510821 PubMed 12422359 PubMed 18306178 PubMed 4#C UniMod From DeltaMass: (name misspelled "Carboxyamidomethyl Cystenyl") [JSG]. PSI-MOD-slim amidocarboxymethylcysteine DeltaMass-label CamC PSI-MOD-alternate CamCys DeltaMass-label Carbamidomethyl PSI-MS-label carbamidomethylc OMSSA-label carbamoylmethylcysteine DeltaMass-label Carboxamidomethyl (on Cysteine) DeltaMass-label Carboxyamidomethyl Cystenyl DeltaMass-label Iodoacetamide derivative UniMod-description S-carbamoylmethyl-L-cysteine PSI-MOD-alternate DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 S 0 DiffMono 57.021464 Formula C 5 H 8 N 2 O 2 S 1 MassAvg 160.19 MassMono 160.030649 Origin C Source artifact TermSpec none MOD:00397 MOD:00905 PSI-MOD MOD:01061 S-carboxymethyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine. 0 DeltaMass 197 DeltaMass 6#C UniMod From DeltaMass with no citation, name misspelled "Carboxymethyl Cystenyl", and formula incorrect, N and O reversed: Average Mass: 161 Abbreviation: -Cmc- Formula: C5H7O1N3S1 Monoisotopic Mass Change: 161.015 Average Mass Change: 161.179 [JSG]. PSI-MOD-slim Carboxymethyl PSI-MS-label Carboxymethyl cysteine DeltaMass-label Carboxymethyl Cystenyl DeltaMass-label carboxymethylc OMSSA-label CmC PSI-MOD-alternate Iodoacetic acid derivative UniMod-description DiffAvg 58.04 DiffFormula C 2 H 2 N 0 O 2 S 0 DiffMono 58.005479 Formula C 5 H 7 N 1 O 3 S 1 MassAvg 161.18 MassMono 161.014664 Origin C Source artifact TermSpec none MOD:00399 MOD:00905 PSI-MOD MOD:01062 carboxymethyl cysteinyl OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061 197 DeltaMass From DeltaMass:197 (Name misspelled "cystenyl", and formula incorrect, N and O reversed) Abbreviation:-Cmc- Formula:C5H7O1N3S1 Monoisotopic Mass Change:161.015 Average Mass Change:161.179 Carboxymethyl Cystenyl DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula C 5 H 7 N 3 O 1 S 1 MassAvg 157.19 MassMono 157.030983 Origin C Source artifact TermSpec none 1 PSI-MOD MOD:01063 monomethylated phenylalanine A protein modification that effectively converts an L-phenylalanine residue to a monomethylated phenylalanine. 198 DeltaMass From DeltaMass: Average Mass: 161 Formula: C10H11O1N1 Monoisotopic Mass Change: 161.084 Average Mass Change: 161.205. No citation provided. It is not obvious whether the DeltaMass entry is supposed to represent N-methylphenylalanine, alpha-methylphenylalanine, 2'-, 3'-, or 4'-methylphenylalanine [JSG]. PSI-MOD-slim NMePhe PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 10 H 11 N 1 O 1 MassAvg 161.20 MassMono 161.084064 Origin F Source none TermSpec none MOD:00599 MOD:00717 PSI-MOD MOD:01064 inositol modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 162 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01065 hexose glycated N-terminal A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein N-terminal amino group to form a Schiff-base or an Amadori ketosamine (or aminoketose) residue adduct. 0 DeltaMass 41#N-term UniMod From DeltaMass: Average Mass: 162 DiffAvg 162.14 DiffFormula C 6 H 10 O 5 DiffMono 162.052823 Formula none MassAvg none MassMono none Origin none Source none TermSpec N-term MOD:00767 PSI-MOD MOD:01066 halogenated phenylalanine A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a halogen atom. 18688235 PubMed HalPhe PSI-MOD-label Origin F Source none TermSpec none MOD:00694 MOD:00914 PSI-MOD MOD:01067 linker attached to peptide in Fmoc peptide synthesis modification from DeltaMass 341 DeltaMass From DeltaMass: Average Mass: 162 Average Mass Change:162 Notes: (from the ABRF discussion list archive) There may be ... things in the reagent K that would allow cleavage of the peptide to occur at the wrong place...in this case it removes the dimethoxybenzyl group first inactivating that site for cleavage, and it goes after tne next amide bond closer to the resin. Try the TFA/TIS/water/EDT cocktail...TFA = 92%, TIS =3%, and water is at 5%. .. had this issue on longer peptides.. and by increasing the amount of water a little bit... able to elminate this problem. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01068 halogenated tryptophan A protein modification that effectively substitutes a hydrogen atom of an L-tryptophan residue with a halogen atom. 18688235 PubMed HalTrp PSI-MOD-label Origin W Source none TermSpec none MOD:00694 MOD:00918 PSI-MOD MOD:01069 2,4-dinitrophenyl modified residue A protein modification that effectively substitutes a 2,4-dinitrophenyl group for a hydrogen atom. 0 DeltaMass Dnp DeltaMass-label DiffAvg 166.09 DiffFormula C 6 H 2 N 2 O 4 DiffMono 166.001457 Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01070 pentafluorophenyl modified residue A protein modification that effectively substitutes a pentafluorophenyl group for a hydrogen atom. 0 DeltaMass From DeltaMass: name mispelled "pentaflourophenyl" Pfp DeltaMass-label DiffAvg 166.05 DiffFormula C 6 F 5 H -1 DiffMono 165.984191 Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01071 diphenylmethyl modified residue A protein modification that effectively substitutes a diphenylmethyl group for a hydrogen atom. 0 DeltaMass Dpm DeltaMass-label DiffAvg 166.22 DiffFormula C 13 H 10 DiffMono 166.078250 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01072 monopotassium salt A protein modification that effectively substitutes one potassium atom for one hydrogen atom. 0 DeltaMass PSI-MOD-slim K1Res PSI-MOD-label DiffAvg 38.09 DiffFormula H -1 K 1 DiffMono 37.955882 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00849 PSI-MOD MOD:01073 2-chlorobenzyloxycarbonyl modified residue A protein modification that effectively substitutes a 2-chlorobenzyloxycarbonyl group for a hydrogen atom. 0 DeltaMass Clz DeltaMass-label DiffAvg 169.58 DiffFormula C 8 Cl 1 H 6 O 2 DiffMono 169.005632 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01074 napthylacetyl modified residue A protein modification that effectively substitutes a napthylacetyl group for a hydrogen atom. 0 DeltaMass DiffAvg 169.20 DiffFormula C 12 H 9 O 1 DiffMono 169.065340 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01075 mercury containing modified residue A protein modification that effectively substitutes a mercury atom or a cluster containing mercury for hydrogen atoms, or that coordinates a mercury ion. 18688235 PubMed HgRes PSI-MOD-label MOD:00698 PSI-MOD MOD:01076 N-methyl arginyl modification from DeltaMass - OBSOLETE because redundant and identical to MOD:00414. Remap to MOD:00414. 215 DeltaMass From DeltaMass: Average Mass: 170 Formula:C7H14O4N1 Monoisotopic Mass Change:170.117 Average Mass Change:170.215 DiffAvg none DiffFormula none DiffMono none Formula C 7 H 14 N 4 O 1 MassAvg 170.22 MassMono 170.116761 Origin R Source none TermSpec none 1 PSI-MOD MOD:01077 ethanedithiol/TFA cyclic adduct modification from DeltaMass 216 DeltaMass From DeltaMass: Average Mass: 172 Average Mass Change:172 References:[1]. Sieber,P.(1987) Modification of tryptophan residues during acidolysis of4-methoxy-2,3,6-trimethylbenzenesulfonyl groups. Effects of scavengers. Tetrahedron Lett., 28(15),1637-1640. Notes: TFA-cyclic dithioketal by-product is formed when Trp-containing peptide is subjected to prolonged TFA/EDT treatment [1]. See structure at http://www.abrf.org/images/misc/dmass172.gif. Additional discussion of this adduct, and how to avoid it, can befound in Methods in Enzymology 289, 67 (1997) DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01078 S-(2-aminoethyl)-3-methylcysteine (Thr) A protein modification that effectively converts an L-threonine residue to S-(2-aminoethyl)-3-methylcysteine. 12923550 PubMed 472#T UniMod From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. 2-amino-3-(2-aminoethyl)sulfanyl-3-methylbutanoic acid PSI-MOD-alternate AEC-MAEC UniMod-interim beta-methylaminoethylcysteine UniMod-description S-aminoethyl-3-methylcysteine PSI-MOD-alternate DiffAvg 59.13 DiffFormula C 2 H 5 N 1 O -1 S 1 DiffMono 59.019356 Formula C 6 H 12 N 2 O 1 S 1 MassAvg 160.24 MassMono 160.067034 Origin T Source artifact TermSpec none MOD:00917 PSI-MOD MOD:01079 S-(acetylamino)methyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-[(acetylamino)methyl]-L-cysteine. 218 DeltaMass 8572278 PubMed From DeltaMass: (name misspelled "Acetamidomethyl Cystenyl") Average Mass: 174 Formula: C 6 H 10 O 2 N 2 S 1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221. [These are aggregate masses, not delta masses.] See Organic Syntheses, Coll. Vol. 6, p.5 (1988); Vol. 59, p.190 (1979); http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv6p0005 [JSG]. Acetamidomethyl Cystenyl DeltaMass-label Acm-Cys PSI-MOD-alternate N-(hydroxymethyl)acetamide derivatized L-cysteine PSI-MOD-alternate S-(acetamido)methyl-L-cysteine PSI-MOD-alternate DiffAvg 71.08 DiffFormula C 3 H 5 N 1 O 1 S 0 DiffMono 71.037114 Formula C 6 H 10 N 2 O 2 S 1 MassAvg 174.22 MassMono 174.046299 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:01080 acrylamidyl cysteinyl modification from DeltaMass 219 DeltaMass From DeltaMass: (name misspelled "Acrylamidyl Cystenyl") Average Mass: 174 Formula: C6H10O2N2S1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221 Acrylamidyl Cystenyl DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula C 6 H 10 N 2 O 2 S 1 MassAvg 174.22 MassMono 174.046299 Origin C Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01081 delta-glycosyloxy- (of lysine) or beta-glycosyloxy- (of phenylalanine or tyrosine) modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 177. CAUTION - mass does not match formula. DiffAvg 178.14 DiffFormula C 6 H 10 O 6 DiffMono 178.047738 Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01082 4-glycosyloxy- (hexosyl, C6) (of proline) modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 177. Caution: Formula does not match mass. The natural glycosylating sugar of hydroxyproline is galactose. DiffAvg 178.14 DiffFormula C 6 H 10 O 6 DiffMono 178.047738 Formula C 11 H 17 N 1 O 6 MassAvg 259.26 MassMono 259.105587 Origin P Source none TermSpec none MOD:00947 PSI-MOD MOD:01083 O-benzyl-L-serine A protein modification that effectively converts an L-serine residue to O-benzyl-L-serine. 0 DeltaMass DiffAvg 90.13 DiffFormula C 7 H 6 DiffMono 90.046950 Formula C 10 H 11 N 1 O 2 MassAvg 177.20 MassMono 177.078979 Origin S Source artifact TermSpec none MOD:00916 MOD:01008 PSI-MOD MOD:01084 iodoacetic acid derivatized amino-terminal residue A protein modification that by reaction of iodoacetic acid effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxymethyl group. 6#N-term UniMod PSI-MOD-slim Carboxymethyl PSI-MS-label Carboxymethyl (on Cysteine) DeltaMass-label Iodoacetic acid derivative UniMod-description DiffAvg 58.04 DiffFormula C 2 H 2 O 2 DiffMono 58.005479 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00399 PSI-MOD MOD:01085 alpha-N-gluconoylation (His Tagged proteins) modification from DeltaMass 226 DeltaMass From DeltaMass: Average Mass: 178 Formula: C6H10O6 Monoisotopic Mass Change: 178.05 Average Mass Change: 178.14 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01086 p-nitrobenzyloxycarbonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 179 4Nz DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01087 2,4,5-trichlorophenyl modified residue A protein modification that effectively substitutes a 2,4,5-trichlorophenyl group for a hydrogen atom. 0 DeltaMass DiffAvg 179.42 DiffFormula C 6 Cl 3 H 1 DiffMono 177.914383 Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01088 2,4,6-trimethyloxybenzyl modified residue A protein modification that effectively substitutes a 2,4,6-trimethyloxybenzyl group for a hydrogen atom. 0 DeltaMass Tmob DeltaMass-label DiffAvg 180.20 DiffFormula C 10 H 12 O 3 DiffMono 180.078644 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01089 xanthyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 180 Xan DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01090 iodoacetamide derivatized amino-terminal residue A protein modification that by reaction of iodoacetamide effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxamidomethyl group. 11327326 PubMed 11510821 PubMed 12422359 PubMed 4#N-term UniMod PSI-MOD-slim (carbamoylmethyl)amino PSI-MOD-alternate Carbamidomethyl PSI-MS-label Iodoacetamide derivative UniMod-description DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00397 PSI-MOD MOD:01091 monochlorinated L-phenylalanine A protein modification that effectively substitutes one hydrogen atom of an L-phenylalanine residue with one chlorine atom. 233 DeltaMass From DeltaMass: Average Mass: 182 Formula:C9H8O1N1Cl1 Monoisotopic Mass Change:181.029 Average Mass Change:181.623 Cl1Phe PSI-MOD-label DiffAvg 34.44 DiffFormula C 0 Cl 1 H -1 N 0 O 0 DiffMono 33.961028 Formula C 9 Cl 1 H 8 N 1 O 1 MassAvg 181.62 MassMono 181.029442 Origin F Source artifact TermSpec none MOD:01066 MOD:01911 PSI-MOD MOD:01092 mesitylene-2-sulfonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 182 Mts DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01093 isopropyl lysyl modification from DeltaMass 236 DeltaMass From DeltaMass: Average Mass: 184 Formula: C9H16O2N2 Monoisotopic Mass Change: 184.12 Average Mass Change: 184.24 with no citation. DiffAvg none DiffFormula none DiffMono none Formula C 9 H 16 N 2 O 2 MassAvg 184.24 MassMono 184.121178 Origin K Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01094 N6-carboxymethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-carboxymethyl-L-lysine. 237 DeltaMass 6#K UniMod From DeltaMass:237 (with no citation, formula incorrect, N and O reversed) Average Mass: 186 Formula: C8H14O2N3 Monoisotopic Mass Change: 186.1 Average Mass Change: 186.211 [JSG]. PSI-MOD-slim Carboxymethyl PSI-MS-label Carboxymethyl Lysyl DeltaMass-label Iodoacetic acid derivative UniMod-description DiffAvg 58.04 DiffFormula C 2 H 2 O 2 DiffMono 58.005479 Formula C 8 H 14 N 2 O 3 MassAvg 186.21 MassMono 186.100442 Origin K Source artifact TermSpec none MOD:00399 PSI-MOD MOD:01095 Matrix alpha cyano MH+ Modification from DeltaMass. OBSOLETE because not an amino acid modification. 240 DeltaMass From DeltaMass with no citation, formula incorrect, N and O reversed: Formula: C10H8O1N3 Monoisotopic Mass Change: 190.05 Average Mass Change: 190.18. DiffAvg none DiffFormula none DiffMono none Formula C 10 H 8 N 1 O 3 MassAvg 190.18 MassMono 190.050418 Origin X Source artifact TermSpec none 1 PSI-MOD MOD:01096 O-benzyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-benzyl-L-threonine. 0 DeltaMass DiffAvg 90.13 DiffFormula C 7 H 6 DiffMono 90.046950 Formula C 11 H 13 N 1 O 2 MassAvg 191.23 MassMono 191.094629 Origin T Source artifact TermSpec none MOD:00917 MOD:01008 PSI-MOD MOD:01097 S-benzyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-benzyl-L-cysteine. 242 DeltaMass From DeltaMass: misspelled "Benzyl Cystenyl". DiffAvg 90.13 DiffFormula C 7 H 6 DiffMono 90.046950 Formula C 10 H 11 N 1 O 1 S 1 MassAvg 193.26 MassMono 193.056135 Origin C Source artifact TermSpec none MOD:00905 MOD:01008 PSI-MOD MOD:01098 naphthylalanine residue A protein modification that inserts or replaces a residue with a naphthylalanine. 243 DeltaMass From DeltaMass: Average Mass: 197 Formula: C13H11O1N1 Monoisotopic Mass Change: 197.084 Average Mass Change: 197.238. No citation provided. It is not obvious which isomer of naphthylalanine this DeltaMass entry is supposed to represent [JSG]. DiffAvg none DiffFormula none DiffMono none Formula C 13 H 11 N 1 O 1 MassAvg 197.24 MassMono 197.084064 Origin X Source artifact TermSpec none MOD:00850 PSI-MOD MOD:01099 succinyl beta-aspartyl anhydride A protein modification that effectively converts an L-aspartic acid residue to succinyl beta-aspartyl anhydride. 244 DeltaMass From DeltaMass with no citation (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 198 Formula: C8H8O1N5 Monoisotopic Mass Change: 198.04 Average Mass Change: 198.156 [JSG]. succinyl aspartamyl DeltaMass-label DiffAvg 82.06 DiffFormula C 4 H 2 N 0 O 2 DiffMono 82.005479 Formula C 8 H 8 N 1 O 5 MassAvg 198.15 MassMono 198.040247 Origin D Source artifact TermSpec N-term MOD:00904 MOD:01029 PSI-MOD MOD:01100 HMP (hydroxymethylphenyl)/TFA adduct modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 201 with no citation. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01101 S-Farnesyl- OBSOLETE because erroneous and apparently redundant to MOD:00111. Remap to MOD:00111. 0 DeltaMass Modification from DeltaMass: Average Mass: 206. This entry with no other information available appears to be the same as the entry at 204 for "Farnesylation" but with an incorrect mass. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none 1 PSI-MOD MOD:01102 myristoylation-4H (two double bonds) OBSOLETE because redundant and identical to MOD:00504. Remap to MOD:00504. 348 DeltaMass From DeltaMass: Average Mass: 206 Formula: C14 H22 O1 Monoisotopic Mass Change: 206.167 Average Mass Change: 206.324 References: Neubert TA, Johnson RS, Hurley JB, Walsh KA (1992). The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. J Biol Chem. 267(26), 18274-7. Notes: Modification of protein N-terminus with (cis,cis-delta 5, delta 8)-tetradecadienoyl group (myristoylation with 2 double bonds) DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source natural TermSpec none 1 PSI-MOD MOD:01103 myristoleylation (one double bond) OBSOLETE because redundant and identical to MOD:00503. Remap to MOD:00503. 0 DeltaMass From DeltaMass with no citation or formula: Average Mass: 208. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source natural TermSpec none 1 PSI-MOD MOD:01104 4-methoxy-2,3,6-trimethylbenzenesulfonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 212 with no citation. Mtr DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01105 2-bromobenzyloxycarbonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 213 with no citation. BrZ DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01106 N-formyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to N-formyl-L-tryptophan. 0 DeltaMass From DeltaMass with no citation or formula: Average Mass: 214. It is not clear what this is supposed to represent. The mass corresponds to an N-formyl tryptophan (either N2 or N1'), but neither of these modifications has been reported as commonly encountered. It may have been confused with N'-formyl-L-kynurenine, see MOD:00464 [JSG] formyl tryptophanyl DeltaMass-label DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 12 H 10 N 2 O 2 MassAvg 214.22 MassMono 214.074228 Origin W Source artifact TermSpec none MOD:00409 MOD:00918 PSI-MOD MOD:01107 O5-benzyl-L-glutamate A protein modification that effectively converts an L-glutamic acid residue to O5-benzyl-L-glutamate. 258 DeltaMass From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. DiffAvg 90.13 DiffFormula C 7 H 6 DiffMono 90.046950 Formula C 12 H 13 N 1 O 3 MassAvg 219.24 MassMono 219.089543 Origin E Source artifact TermSpec none MOD:00906 MOD:01008 PSI-MOD MOD:01108 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid (Glu) A protein modification that effectively converts an L-glutamic acid residue to 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid, glutamtic acid anisole adduct. 259 DeltaMass From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. anisole adducted glutamyl DeltaMass-label DiffAvg 90.13 DiffFormula C 7 H 6 DiffMono 90.046950 Formula C 12 H 13 N 1 O 3 MassAvg 219.24 MassMono 219.089543 Origin E Source artifact TermSpec none MOD:00906 MOD:01007 PSI-MOD MOD:01109 9-fluorenylmethyloxycarbonyl (Fmoc) modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 222 with no citation. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01110 isoprenylated cysteine A protein modification that effectively replaces a hydrogen atom of an L-cysteine residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20). 18688235 PubMed PSI-MOD-slim IpCys PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source none TermSpec none MOD:00703 MOD:00905 PSI-MOD MOD:01111 dimethoxybenzhydryl modified residue A protein modification that effectively substitutes a dimethoxybenzhydryl group for a hydrogen atom. 0 DeltaMass From DeltaMass: Average Mass: 226 with no citation. A reagent, typically 4,4'-dimethoxybenzhydryl chloride, used as a protecting group for the carboxamido group of asparagine and glutamine during chemical peptide synthesis [JSG]. 4,4'-dimethoxybenzhydryl PSI-MOD-alternate bis(4-methoxyphenyl)methyl PSI-MOD-alternate Mbh DeltaMass-label DiffAvg 226.27 DiffFormula C 15 H 14 O 2 DiffMono 226.099380 Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01112 nicotinoyl lysine modification from DeltaMass 266 DeltaMass From DeltaMass: (name misspelled "nicotinyl"; formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 233 Formula: C12H15O3N2 Monoisotopic Mass Change: 233.116 Average Mass Change: 233.271 nicotinyl lysyl DeltaMass-label DiffAvg 105.10 DiffFormula C 6 H 3 N 1 O 1 DiffMono 105.021464 Formula C 12 H 15 N 3 O 2 MassAvg 233.27 MassMono 233.116427 Origin K Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01113 2-(p-biphenyl)isopropyl-oxycarbonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 238 with no citation. Bpoc DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01114 triphenylmethyl modification from DeltaMass 270 DeltaMass From DeltaMass: Average Mass: 242 Average Mass Change: 242.3 Notes: blocking group used in peptide synthesis for C,H,Q,N Trityl DeltaMass-label Trt DeltaMass-label DiffAvg 242.32 DiffFormula C 19 H 14 DiffMono 242.109550 Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01115 isoprenylated tryptophan A protein modification that effectively replaces a hydrogen atom of an L-tryptophan residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20). 18688235 PubMed IpTrp PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin W Source none TermSpec none MOD:00703 MOD:00918 PSI-MOD MOD:01116 S-farnesyl-L-cysteine methyl ester A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester. 15609361 PubMed AA0102#var RESID AA0105#var RESID PSI-MOD-slim SFarnOMeCys PSI-MOD-label DiffAvg 218.38 DiffFormula C 16 H 26 N 0 O 0 S 0 DiffMono 218.203451 Formula C 19 H 32 N 1 O 2 S 1 MassAvg 338.53 MassMono 338.215375 Origin C Source natural TermSpec C-term MOD:00905 has_functional_parent MOD:001110 has_functional_parent MOD:001140 PSI-MOD MOD:01117 pentamethyldihydrobenzofuransulfonyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 252 with no citation. Pbf DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01118 alpha-N-6-phosphogluconoylation (His Tagged proteins) modification from DeltaMass 275 DeltaMass From DeltaMass: Average Mass: 258 Formula: C6H10O6HPO3 Monoisotopic Mass Change: 258.01 Average Mass Change: 258.12 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01119 S-geranylgeranyl-L-cysteine methyl ester A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine methyl ester. 1483450 PubMed 15609361 PubMed AA0104#var RESID AA0105#var RESID PSI-MOD-slim SGergerOMeCys PSI-MOD-label DiffAvg 286.50 DiffFormula C 21 H 34 N 0 O 0 S 0 DiffMono 286.266051 Formula C 24 H 40 N 1 O 2 S 1 MassAvg 406.65 MassMono 406.277976 Origin C Source natural TermSpec C-term MOD:00905 has_functional_parent MOD:001130 has_functional_parent MOD:001140 PSI-MOD MOD:01120 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue A protein modification that is produced by formation of an adduct with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride. 0 DeltaMass From DeltaMass: Average Mass: 266 Notes: blocking group for Arg in peptide synthesis. CAS:112160-39-1 [JSG]. 2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromene-6-sulfonyl PSI-MOD-alternate 2,2,5,7,8-pentamethyl-6-chromansulfonyl PSI-MOD-alternate 2,2,5,7,8-pentamethyl-chromane-6-sulfonyl PSI-MOD-alternate 2,2,5,7,8-pentamethylchroman-6-sulfonyl PSI-MOD-alternate 2,2,5,7,8-pentamethylchroman-6-sulphonyl PSI-MOD-alternate 3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonyl PSI-MOD-alternate Pmc DeltaMass-label PmcRes PSI-MOD-label DiffAvg 266.36 DiffFormula C 14 H 18 O 3 S 1 DiffMono 266.097665 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01652 PSI-MOD MOD:01121 monomethoxytrityl modification from DeltaMass 280 DeltaMass From DeltaMass: Average Mass: 272 Average Mass Change: 272 Mmt DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01122 5'phos dCytidinyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 289 with no citation. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01123 monoiodated tyrosine OBSOLETE because redundant and identical to MOD:01123. Remap to MOD:01123. 0 DeltaMass From DeltaMass: Average Mass: 289 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin Y Source none TermSpec none 1 PSI-MOD MOD:01124 aldohexosyl lysyl modification from DeltaMass 285 DeltaMass From DeltaMass: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 290 Formula: C12H22O2N6 Monoisotopic Mass Change: 290.148 Average Mass Change: 290.317 DiffAvg 162.14 DiffFormula C 6 H 10 N 0 O 5 DiffMono 162.052823 Formula C 12 H 22 N 2 O 6 MassAvg 290.32 MassMono 290.147786 Origin K Source none TermSpec none MOD:00947 PSI-MOD MOD:01125 5'phos dThymidinyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 304 with no citation. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01126 5'phos Cytidinyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 305 with no citation. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01127 5'phos Uridinyl OBSOLETE because redundant and identical to MOD:01166. Remap to MOD:01166. 292 DeltaMass From DeltaMass: Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none 1 PSI-MOD MOD:01128 N-glycolneuraminic acid modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 307 with no citation. NeuGc DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01129 5'phos dAdenosyl modification from DeltaMass 295 DeltaMass From DeltaMass: Average Mass: 313 Formula: C10H12O5N5P1 Monoisotopic Mass Change: 313.058 Average Mass Change: 313.211 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01130 SucPhencarb Lysyl modification from DeltaMass 297 DeltaMass From DeltaMass: Average Mass: 327 Formula: C17H17O3N4 Monoisotopic Mass Change: 327.122 Average Mass Change: 327.342 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01131 5'phos dGuanosyl modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 329 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01132 5'phos Adenosinyl OBSOLETE because redundant and identical to MOD:01165. Remap to MOD:01165. 0 DeltaMass From DeltaMass: Average Mass: 329 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none 1 PSI-MOD MOD:01133 S-12-hydroxyfarnesyl-L-cysteine methyl ester A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine methyl ester. 17790543 PubMed AA0103#var RESID AA0105#var RESID S12HyFarnOMeCys PSI-MOD-label DiffAvg 234.38 DiffFormula C 16 H 26 N 0 O 1 S 0 DiffMono 234.198365 Formula C 19 H 32 N 1 O 3 S 1 MassAvg 354.53 MassMono 354.210290 Origin C Source natural TermSpec C-term MOD:00905 has_functional_parent MOD:001120 has_functional_parent MOD:001140 PSI-MOD MOD:01134 fluorescein labelling of peptide N-terminal using NHS ester modification from DeltaMass 306 DeltaMass From DeltaMass: Average Mass: 359 Formula: C21H11O6 Monoisotopic Mass Change: 359.055 Average Mass Change: 359.315 Notes: Using the DHB matrix at low pH the carboxyl group and one of the oxygens on the flurorescein molecule are protinated so the delta mass is 2Da higher than most text book illustrations would indicate. See Bioconjugate Techniques by Greg Hermanson, Academic Press, page 305, figure 204. Text books of course just show the coupling reaction at neutral or basic pH. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01135 Hex-HexNAc modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 365 with no citation. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01136 dioctyl phthalate modification from DeltaMass 309 DeltaMass From DeltaMass: Average Mass: 391 Average Mass Change: 391 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01137 N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine A protein modification that is produced by reaction of a lysine residue with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine. 310 DeltaMass From DeltaMass: Average Mass: Formula: C20H30O2N4S1 Monoisotopic Mass Change: 394.192 Average Mass Change: 394.534 PMC lysyl DeltaMass-label PmcLys PSI-MOD-label DiffAvg 266.36 DiffFormula C 14 H 18 O 3 S 1 DiffMono 266.097665 Formula C 20 H 30 N 2 O 4 S 1 MassAvg 394.53 MassMono 394.192628 Origin K Source artifact TermSpec none MOD:00902 MOD:01120 PSI-MOD MOD:01138 Aedans Cystenyl modification from DeltaMass 311 DeltaMass [probably aminoethyldansyl, JSG] From DeltaMass: (name misspelled "Aedans Cystenyl", and formula incorrect, N and O reversed) Average Mass: 409 Abbreviation: Aedans-Cys Formula: C17H19O3N5S2 Monoisotopic Mass Change: 409.077 Average Mass Change: 409.482 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01139 dioctyl phthalate sodium adduct modification from DeltaMass 312 DeltaMass From DeltaMass: Mass: Average Mass Change: 413 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source artifact TermSpec none MOD:00947 PSI-MOD MOD:01140 diiodinated tyrosine A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two iodine atoms. 0 DeltaMass 15627961 PubMed 130#Y UniMod PSI-MOD-slim 3,5-Diiodination (of Tyrosine) DeltaMass-label di-Iodination UniMod-description diiodinationy OMSSA-label Diiodo PSI-MS-label I2Tyr PSI-MOD-label DiffAvg 251.79 DiffFormula C 0 H -2 I 2 N 0 O 0 DiffMono 251.793295 Formula C 9 H 7 I 2 N 1 O 2 MassAvg 414.97 MassMono 414.856624 Origin Y Source natural TermSpec none MOD:00501 MOD:00998 PSI-MOD MOD:01141 omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine A protein modification that is produced by reaction with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine. 314 DeltaMass From DeltaMass: Average Mass: Formula: C20H30O4N4S1 Monoisotopic Mass Change: 422.199 Average Mass Change: 422.547 PMC arginyl DeltaMass-label PmcArg PSI-MOD-label DiffAvg 266.36 DiffFormula C 14 H 18 O 3 S 1 DiffMono 266.097665 Formula C 20 H 30 N 4 O 4 S 1 MassAvg 422.54 MassMono 422.198776 Origin R Source artifact TermSpec none MOD:00902 MOD:01120 PSI-MOD MOD:01142 S-15,16-dihydrobiliverdin-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound 15,16-dihydrobiliverdin. 10430868 PubMed 15504407 PubMed 1559975 PubMed 3208761 PubMed AA0428 RESID (16R)-18-ethenyl-8,12-bis(2-carboxyethyl)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione RESID-systematic 15,16-Dhbv RESID-alternate 15,16-dihydrobiliverdin cysteine adduct RESID-alternate 15,16-dihydrobiliverdin IXalpha RESID-alternate 18-ethenyl-8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione RESID-alternate 3'-cysteinyl-15,16-dihydrobiliverdin RESID-alternate 3alpha-cysteinyl-15,16-dihydrobiliverdin RESID-alternate BINDING 15,16-dihydrobiliverdin (covalent; via 1 link) UniProt-feature DBV RESID-alternate S-15,16-dihydrobiliverdin-L-cysteine RESID-name DiffAvg 584.67 DiffFormula C 33 H 36 N 4 O 6 S 0 DiffMono 584.263485 Formula C 36 H 41 N 5 O 7 S 1 MassAvg 687.81 MassMono 687.272670 Origin C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:01143 15,16-dihydrobiliverdin-bis-L-cysteine A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound 15,16-dihydrobiliverdin. 1559975 PubMed 2222853 PubMed 3208761 PubMed 8420941 PubMed AA0429 RESID Cross-link 2. (16R)-8,12-bis(2-carboxyethyl)-3-[2-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-[(1Xi)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione RESID-systematic 15,16-Dhbv RESID-alternate 15,16-dihydrobiliverdin cysteine adduct RESID-alternate 15,16-dihydrobiliverdin IXalpha RESID-alternate 15,16-dihydrobiliverdin-bis-L-cysteine RESID-name 3'',18'-biscysteinyl-15,16-dihydrobiliverdin RESID-alternate 3beta,18alpha-biscysteinyl-15,16-dihydrobiliverdin RESID-alternate 8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-18-(1-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione RESID-alternate BINDING 15,16-dihydrobiliverdin (covalent; via 2 links) UniProt-feature DBV RESID-alternate DiffAvg 584.67 DiffFormula C 33 H 36 N 4 O 6 S 0 DiffMono 584.263485 Formula C 39 H 46 N 6 O 8 S 2 MassAvg 790.95 MassMono 790.281854 Origin C, C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:01144 S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine. 0 DeltaMass 10896212 PubMed 4575979 PubMed 9056182 PubMed AA0107#var RESID From DeltaMass: Average Mass: 524 PSI-MOD-slim S-(sn-1-Dipalmitoyl-glyceryl)- (on Cysteine) DeltaMass-label DiffAvg 550.91 DiffFormula C 35 H 66 N 0 O 4 S 0 DiffMono 550.496111 Formula C 38 H 71 N 1 O 5 S 1 MassAvg 654.05 MassMono 653.505295 Origin C Source natural TermSpec none MOD:00116 PSI-MOD MOD:01145 N-tau-(ADP-ribosyl)diphthamide A protein modification that effectively converts an L-histidine residue to N-tau-(ADP-ribosyl)diphthamide. 0 DeltaMass From DeltaMass: (name misspelled "N theta -(ADP-ribosyl) diphthamide (of Histidine)") Average Mass: 648 DiffAvg 684.51 DiffFormula C 22 H 36 N 7 O 14 P 2 DiffMono 684.178999 FormalCharge 1+ Formula C 28 H 43 N 10 O 15 P 2 MassAvg 821.65 MassMono 821.237910 Origin H Source natural TermSpec none MOD:00752 MOD:00909 derives_from MOD:000490 PSI-MOD MOD:01146 S-(6-FAD)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(6-FAD)-L-cystine. 0 DeltaMass From DeltaMass: Average Mass: 784 with no citation. This modification has not been reported [JSG]. PSI-MOD-slim FAD PSI-MS-label S6FADCys PSI-MOD-label DiffAvg 783.54 DiffFormula C 27 H 31 N 9 O 15 P 2 S 0 DiffMono 783.141485 Formula C 30 H 36 N 10 O 16 P 2 S 1 MassAvg 886.68 MassMono 886.150669 Origin C Source hypothetical TermSpec none MOD:00895 MOD:00905 PSI-MOD MOD:01147 (Hex)3-HexNAc-(dHex)HexNAc modification from DeltaMass 0 DeltaMass From DeltaMass: Average Mass: 1,039 DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin none Source none TermSpec none MOD:00947 PSI-MOD MOD:01148 ubiquitinylated lysine A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin. 11125103 PubMed 18688235 PubMed PSI-MOD-slim Origin K Source natural TermSpec none MOD:00908 MOD:01875 contains MOD:001340 PSI-MOD MOD:01149 sumoylated lysine A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein. 12612601 PubMed 18688235 PubMed PSI-MOD-slim Origin K Source natural TermSpec none MOD:00908 MOD:01875 contains MOD:001340 PSI-MOD MOD:01150 neddylated lysine A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein. 11125103 PubMed 12612601 PubMed 18688235 PubMed PSI-MOD-slim Origin K Source natural TermSpec none MOD:00908 MOD:01875 contains MOD:001340 PSI-MOD MOD:01151 phosphorylated residue with neutral loss of phosphate Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid phosphorylated residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment. 18688235 PubMed PSI-MOD-slim DiffAvg -97.99 DiffFormula C 0 H -3 N 0 O -4 P -1 DiffMono -97.976895 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00432 PSI-MOD MOD:01152 carboxylated residue A protein modification that effectively replaces a hydrogen atom with a carboxylic acid group. 299 UniMod PSI-MOD-slim Carboxy UniMod-interim Carboxylation UniMod-description DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 DiffMono 43.989829 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:01156 PSI-MOD MOD:01153 methylthiolated residue A protein modification that effectively replaces a hydrogen atom with an methylsulfanyl group (thiomethyl group). 39 UniMod PSI-MOD-slim Beta-methylthiolation UniMod-description Methylthio UniMod-interim DiffAvg 46.09 DiffFormula C 1 H 2 N 0 O 0 S 1 DiffMono 45.987721 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:01886 PSI-MOD MOD:01154 pyruvic acid A protein modification that effectively converts a source amino acid to pyruvic acid. 10085076 PubMed 3042771 PubMed 8464063 PubMed AA0127 RESID PSI-MOD-slim 2-oxopropanoic acid RESID-systematic MOD_RES Pyruvic acid (Cys) UniProt-feature MOD_RES Pyruvic acid (Ser) UniProt-feature pyruvic acid RESID-name DiffAvg none DiffFormula none DiffMono none Formula C 3 H 3 O 2 MassAvg 71.06 MassMono 71.013304 Origin X Source none TermSpec N-term MOD:00769 MOD:00859 PSI-MOD MOD:01155 lipoconjugated residue A protein modification that effectively results from forming an adduct with a compound containing a lipid-like group either through acylation, alkylation, or amidation. 18688235 PubMed PSI-MOD-slim MOD:01156 PSI-MOD MOD:01156 protein modification categorized by chemical process Modified amino acid residue derived from a natural amino acid by a real or hypothetical chemical process. 18688235 PubMed PSI-MOD-slim MOD:00000 PSI-MOD MOD:01157 protein modification categorized by amino acid modified A protein modification considered either as modified amino acid residues derived from natural amino acids, as a replacement by another natural amino acid, or as a replacement by an unnatural amino acid. 18688235 PubMed PSI-MOD-slim MOD:00000 PSI-MOD MOD:01158 modified L-selenocysteine residue A protein modification that modifies an L-selenocysteine residue. 18688235 PubMed PSI-MOD-slim Origin U MOD:00745 MOD:01157 derives_from MOD:000310 PSI-MOD MOD:01159 peptidoglycanated residue A protein modification that effectively attaches a residue to murein peptidoglycan by either a pentaglycine linker peptide or a peptide-like L-alanyl-D-glutamyl-2,6-diaminopimelic acid linkage. 18688235 PubMed Origin X Source natural TermSpec none MOD:00764 PSI-MOD MOD:01160 deaminated residue A protein modification that effectively results in the loss of an ammonia, usually by a process of vicinal dehydration, rearrangement, and rehydration with release of ammonia, resulting in a loss of nitrogen with no gain of oxygen. 385 UniMod PSI-MOD-slim Ammonia-loss UniMod-interim Loss of ammonia UniMod-description DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:01156 PSI-MOD MOD:01161 deoxygenated residue A protein modification that effectively removes oxygen atoms from a residue without the removal of hydrogen atoms. 14235557 PubMed 447 UniMod PSI-MOD-slim Deoxy PSI-MS-label dOxyRes PSI-MOD-label reduction UniMod-description DiffAvg -16.00 DiffFormula C 0 H 0 N 0 O -1 DiffMono -15.994915 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:01472 PSI-MOD MOD:01162 fucosylated biantennary modification from UniMod N-linked glycosylation 308 UniMod dHex(1)Hex(5)HexNAc(4) PSI-MS-label Fucosylated biantennary UniMod-description DiffAvg 1769.62 DiffFormula C 68 H 112 N 4 O 49 DiffMono 1768.639516 Formula C 72 H 118 N 6 O 51 MassAvg 1883.73 MassMono 1882.682443 Origin N Source natural TermSpec none MOD:00725 PSI-MOD MOD:01163 guanylated residue A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoguanosine through either a phosphodiester or a phosphoramide bond. 304 DeltaMass 413 UniMod From DeltaMass: (formula incorrect, N and O reversed) Average Mass: 345 Formula: C10H12O5N7P1 Monoisotopic Mass Change: 345.047 Average Mass Change: 345.209. 5'phos Guanosyl DeltaMass-label phospho-guanosine UniMod-description Phosphoguanosine PSI-MS-label DiffAvg 345.21 DiffFormula C 10 H 12 N 5 O 7 P 1 DiffMono 345.047434 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00701 PSI-MOD MOD:01164 riboflavin-phosphoryl A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through a phosphodiester bond. 442 UniMod PSI-MOD-slim FMN PSI-MS-label O3-(riboflavin phosphoryl) UniMod-description DiffAvg 438.33 DiffFormula C 17 H 19 N 4 O 8 P 1 DiffMono 438.094050 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00896 PSI-MOD MOD:01165 adenylated residue A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoadenosine through either a phosphodiester or a phosphoramide bond. 0 DeltaMass 405 UniMod From DeltaMass: (name misspelled "5'phos adenosinyl") Average Mass: 329 PSI-MOD-slim 5'phos Adenosinyl DeltaMass-label AMP binding site UniMod-description Phosphoadenosine PSI-MS-label DiffAvg 329.21 DiffFormula C 10 H 12 N 5 O 6 P 1 DiffMono 329.052520 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00701 PSI-MOD MOD:01166 uridylated residue A protein modification that effectively crosslinks an amino acid residue and 5'-phosphouridine through either a phosphodiester or a phosphoramide bond. 292 DeltaMass 417 UniMod From DeltaMass: (name misspelled "5'phos Uridinyl" and formula incorrect, N and O reversed) Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 5'phos Uridinyl DeltaMass-label PhosphoUridine PSI-MS-label uridine phosphodiester UniMod-description DiffAvg 306.17 DiffFormula C 9 H 11 N 2 O 8 P 1 DiffMono 306.025302 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00701 PSI-MOD MOD:01167 molybdopterin guanine dinucleotide modification from UniMod 424 UniMod molybdenum bis(molybdopterin guanine dinucleotide) UniMod-description MolybdopterinGD PSI-MS-label DiffAvg 1572.02 DiffFormula C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 DiffMono 1572.985775 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00744 PSI-MOD MOD:01168 dehydroalanine A protein modification that effectively converts a source amino acid residue to dehydroalanine. 10220322 PubMed 1547888 PubMed 1815586 PubMed 2914619 PubMed 6838602 PubMed 7947813 PubMed 8239649 PubMed AA0181 RESID PSI-MOD-slim 2,3-didehydroalanine RESID-alternate 2-aminoacrylic acid RESID-alternate 2-aminopropenoic acid RESID-systematic 4-methylidene-imidazole-5-one (MIO) active site RESID-alternate anhydroserine RESID-alternate dehydroalanine RESID-name Dha RESID-alternate dHAla PSI-MOD-label MOD_RES 2,3-didehydroalanine (Cys) UniProt-feature MOD_RES 2,3-didehydroalanine (Ser) UniProt-feature DiffAvg none DiffFormula none DiffMono none Formula C 3 H 3 N 1 O 1 MassAvg 69.06 MassMono 69.021464 Origin X Source natural TermSpec none MOD:00859 PSI-MOD MOD:01169 L-3-oxoalanine A protein modification that effectively converts a source amino acid residue to L-oxoalanine. 349 DeltaMass 14563551 PubMed 7628016 PubMed 8681943 PubMed 9478923 PubMed AA0185 RESID PSI-MOD-slim (S)-2-amino-3-oxopropanoic acid RESID-systematic 2-amino-3-oxopropionic acid RESID-alternate C(alpha)-formylglycine RESID-misnomer L-3-oxoalanine RESID-name L-amino-malonic acid semialdehyde RESID-alternate L-aminomalonaldehydic acid RESID-alternate L-serinesemialdehyde RESID-misnomer MOD_RES 3-oxoalanine (Cys) UniProt-feature MOD_RES 3-oxoalanine (Ser) UniProt-feature DiffAvg none DiffFormula none DiffMono none Formula C 3 H 3 N 1 O 2 MassAvg 85.06 MassMono 85.016378 Origin X Source natural TermSpec none MOD:00859 PSI-MOD MOD:01170 pyruvic acid iminylated residue A protein modification that effectively forms a 2-ketoimine of pyruvicacid with a residue amino group. 422 UniMod N-pyruvic acid 2-iminyl UniMod-description PyruvicAcidIminyl PSI-MS-label DiffAvg 70.05 DiffFormula C 3 H 2 N 0 O 2 DiffMono 70.005479 Formula none MassAvg none MassMono none Origin X Source none TermSpec N-term MOD:01156 PSI-MOD MOD:01171 O-acetyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-acetyl-L-threonine. 16728640 PubMed AA0423 RESID 1#T UniMod PSI-MOD-slim (2S,3R)-3-(acetyloxy)-2-aminobutanoic acid RESID-systematic Acetylation UniMod-description ACT_SITE O-acetylthreonine intermediate UniProt-feature MOD_RES O-acetylthreonine UniProt-feature O-acetyl-L-threonine RESID-name O-acetylthreonine RESID-alternate OAcThr PSI-MOD-label threonine acetate ester RESID-alternate DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula C 6 H 9 N 1 O 3 MassAvg 143.14 MassMono 143.058243 Origin T Source natural TermSpec none MOD:00644 MOD:01186 PSI-MOD MOD:01172 N-alanyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylsphingolipidinositolethanolamine. 12626404 PubMed AA0424 RESID GSIAla PSI-MOD-label LIPID GPI-like-anchor amidated alanine UniProt-feature N-alanyl-glycosylsphingolipidinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 5 H 12 N 2 O 5 P 1 MassAvg 211.13 MassMono 211.048383 Origin A Source hypothetical TermSpec C-term MOD:00466 MOD:00901 PSI-MOD MOD:01173 N-asparaginyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylsphingolipidinositolethanolamine. 12626404 PubMed AA0425 RESID GSIAsn PSI-MOD-label LIPID GPI-like-anchor amidated asparagine UniProt-feature N-asparaginyl-glycosylsphingolipidinositolethanolamine RESID-name DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 6 H 13 N 3 O 6 P 1 MassAvg 254.16 MassMono 254.054197 Origin N Source hypothetical TermSpec C-term MOD:00466 MOD:00903 PSI-MOD MOD:01174 S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine. 27485 ChEBI 11466314 PubMed 12684535 PubMed AA0426 RESID (2R)-2-amino-3-([(5Z,9Xi,12E,14Z)-1-hydroxy-1,11-oxoprosta-5,12,14-trien-9-yl]sulfanyl)propanoic acid RESID-alternate (5Z,9Xi,12E,14Z)-9-([(2R)-2-amino-3-carboxyethyl]sulfanyl)-11-oxoprosta-5,12,14-trien-1-oic acid RESID-systematic LIPID S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine UniProt-feature PG-J2Cys PSI-MOD-label S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine RESID-name DiffAvg 316.44 DiffFormula C 20 H 28 N 0 O 3 S 0 DiffMono 316.203845 Formula C 23 H 33 N 1 O 4 S 1 MassAvg 419.58 MassMono 419.213030 Origin C Source natural TermSpec none MOD:00905 MOD:01155 PSI-MOD MOD:01175 S-phycourobilin-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycourobilin. 1903388 PubMed 3208761 PubMed 3838747 PubMed AA0427 RESID (2S,3R,16R)-18-ethenyl-3-[(1R)-1-([(R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydrobiline-1,19(21H,22H,24H)-dione RESID-systematic 18-ethenyl-3-[1-(2-amino-2-carboxyethylsulfanyl)ethyl]-2,3,15,16-dihydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid RESID-alternate BINDING Phycourobilin chromophore (covalent; via 1 link) UniProt-feature phycourobilin cysteine adduct RESID-alternate PUB RESID-alternate PUBCys PSI-MOD-label S-phycourobilin-L-cysteine RESID-name DiffAvg 586.69 DiffFormula C 33 H 38 N 4 O 6 S 0 DiffMono 586.279135 Formula C 36 H 43 N 5 O 7 S 1 MassAvg 689.83 MassMono 689.288320 Origin C Source natural TermSpec none MOD:00700 MOD:00905 PSI-MOD MOD:01176 L-dehydrolysinonorleucine A protein modification that effectively cross-links an L-lysine residue and an L-lysine residue converted to allysine with a carbon-nitrogen bond to form L-dehydrolysinonorleucine. 16929109 PubMed AA0430 RESID Cross-link 2. (2S)-2-amino-6-([(5S)-5-amino-5-carboxypentylidene]amino)hexanoic acid RESID-systematic 6-(N6-L-didehydrolysino)-L-norleucine RESID-alternate CROSSLNK Dehydrolysinonorleucine (Lys-Lys) UniProt-feature dehydrolysinorleucine [misspelling] RESID-alternate dehydrolysylnorleucine RESID-alternate didehydrolysinonorleucine RESID-alternate L-dehydrolysinonorleucine RESID-name N6-[(5S)-5-amino-5-carboxypentylidene]-L-lysine RESID-alternate XLNK6NleN6Lys PSI-MOD-label DiffAvg -19.05 DiffFormula C 0 H -5 N -1 O 0 DiffMono -19.042199 Formula C 12 H 19 N 3 O 2 MassAvg 237.30 MassMono 237.147727 Origin K, K Source natural TermSpec none MOD:00692 MOD:00912 PSI-MOD MOD:01177 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine A protein modification that effectively converts an L-histidine residue to 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine. 16760471 PubMed AA0431 RESID (S)-2-amino-3-[1-(1,2,3-trihydroxypropan-2-yl)-1H-imidazol-4-yl]propanoic acid RESID-systematic 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine RESID-name 1-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]-L-histidine RESID-alternate MOD_RES Tele-(1,2,3-trihydroxypropan-2-yl)histidine UniProt-feature N(epsilon)-histidine dihydroxyacetone adduct RESID-alternate N(tau)-(1,2,3-trihydroxypropan-2-yl)histidine RESID-alternate NtauDHAHis PSI-MOD-label tele-(1,2,3-trihydroxypropan-2-yl)histidine RESID-alternate DiffAvg 90.08 DiffFormula C 3 H 6 N 0 O 3 DiffMono 90.031694 Formula C 9 H 13 N 3 O 4 MassAvg 227.22 MassMono 227.090606 Origin H Source natural TermSpec none MOD:00909 PSI-MOD MOD:01178 S-(aspart-4-yloxy) thiocarbonate A protein modification that effectively converts an L-aspartic acid residue to S-(aspart-4-yloxy) thiocarbonate. 16627948 PubMed AA0432 RESID This modification was originally observed in an Entamoeba histolytica enzyme expressed in Escherichia coli. It was not chemically confirmed or characterized. It did not appear in a later model at higher resolution by the same group. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. (2S)-2-amino-4-(carboxysulfanyl)oxy-4-oxobutanoic acid RESID-systematic 4-aspartyloxysulfanylcarbonate RESID-alternate AspOSCO2H PSI-MOD-label O-carboxysulfanyl-4-oxo-L-homoserine RESID-alternate S-(aspart-4-yloxy) thiocarbonate RESID-name DiffAvg 76.07 DiffFormula C 1 H 0 N 0 O 2 S 1 DiffMono 75.961900 Formula C 5 H 5 N 1 O 5 S 1 MassAvg 191.16 MassMono 190.988843 Origin D Source hypothetical TermSpec none MOD:00904 PSI-MOD MOD:01179 N,N-dimethyl-L-alanine A protein modification that effectively converts an L-alanine residue to N,N-dimethyl-L-alanine. 17691833 PubMed 387091 PubMed AA0433 RESID (S)-1-carboxy-N,N-dimethylaminoethane RESID-alternate (S)-2-(dimethylamino)propanoic acid RESID-systematic MOD_RES N,N-dimethylalanine UniProt-feature N,N-dimethyl-L-alanine RESID-name N,N-dimethylalanine RESID-alternate NMe2Ala PSI-MOD-label DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 5 H 10 N 1 O 1 MassAvg 100.14 MassMono 100.076239 Origin A Source natural TermSpec N-term MOD:01461 MOD:01686 PSI-MOD MOD:01180 2-hydroxyglycine observational artifact A protein modification that effectively converts a glycine residue to 2-hydroxyglycine. 38048 ChEBI 16178056 PubMed 17431180 PubMed 17823333 PubMed AA0434 RESID CAUTION - peptides of 2-hydroxyglycine are known to be unstable, decaying to break the peptide backbone or to form peptidyl amides [see J. Am. Chem. Soc. 111, 1933-1934, 1989, and J. Org. Chem. 57, 3916-3921, 1992]. If computer analysis of tandem mass-spectrometric results predicts this modification, then it is most probable that there are multiple isobaric peptides differing in the location of multiple hydroxylation modifications [JSG]. 2-hydroxyglycine RESID-name 2HyGly PSI-MOD-label alpha-hydroxyglycine RESID-alternate amino(hydroxy)acetic acid RESID-systematic aminohydroxyacetic acid RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 2 H 3 N 1 O 2 MassAvg 73.05 MassMono 73.016378 Origin G Source artifact TermSpec none MOD:00425 MOD:00908 PSI-MOD MOD:01181 L-aspartic acid 4-methyl ester A protein modification that effectively converts an L-aspartic acid residue to L-aspartate 4-methyl ester. 1556110 PubMed 16888766 PubMed 9629898 PubMed AA0435 RESID 34#D UniMod CAUTION - observations of this modifation are attributable to artifacts produced in preparation. It is extremely unlikely that eukaryotes produce this modification, because an enzyme acting to form the methyl ester of L-aspartyl peptides would interfere with the D-aspartyl peptide repair mechanism [JSG]. (2S)-2-amino-4-methoxy-4-oxobutanoic acid RESID-systematic 2-aminobutanedioic acid 4-methyl ester RESID-alternate 4-methyl L-2-aminosuccinic acid RESID-alternate 4-methyl L-aspartate RESID-alternate 4-methyl L-hydrogen aspartate RESID-alternate aspartic acid 4-methyl ester RESID-alternate aspartic acid beta-methyl ester RESID-alternate L-aspartic acid 4-methyl ester RESID-name meesterd OMSSA-label Methyl PSI-MS-label O4MeAsp PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin D Source artifact TermSpec none MOD:00393 MOD:01681 PSI-MOD MOD:01182 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD. PubMed AA0436 RESID Cross-link 2. PSI-MOD-slim 6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine RESID-systematic 6-(S-cysteinyl)-8alpha-(N(delta1)-histidyl)-FAD RESID-alternate 6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FAD RESID-alternate 6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FAD RESID-alternate 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD RESID-alternate 6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FAD RESID-name BINDING FAD (covalent; via 2 links) UniProt-feature BINDING FAD (covalent; via 2 links, pros nitrogen) UniProt-feature SCys6-NprosHis8a-FAD PSI-MOD-label DiffAvg 781.52 DiffFormula C 27 H 29 N 9 O 15 P 2 S 0 DiffMono 781.125835 Formula C 36 H 41 N 13 O 17 P 2 S 1 MassAvg 1021.81 MassMono 1021.193931 Origin C, H Source natural TermSpec none MOD:00895 MOD:00905 MOD:00909 MOD:01621 PSI-MOD MOD:01183 L-selenocystine (oxidized selenocysteine) (Sec-Sec) A protein modification that effectively cross-links two L-selenocysteine residues to form L-selenocystine, 28553 ChEBI 17715293 PubMed 6076213 PubMed AA0437 RESID Cross-link 2; for formation of the same modification by substitution of 2 selenium for 2 sulfur atoms in L-cystine, see MOD:01184. PSI-MOD-slim (R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid) RESID-systematic 3,3'-diselenobis(2-aminopropanoic acid) RESID-alternate 3,3'-diselenobisalanine RESID-alternate 3,3'-diselenodialanine RESID-alternate beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide RESID-alternate beta,beta'-diselenodialanine RESID-alternate bis(alpha-aminopropionic acid)-beta-diselenide RESID-alternate bis(beta-amino-beta-carboxyethyl)diselenide RESID-alternate CROSSLNK Selenocystine (Sec-Sec) UniProt-feature diselenocysteine RESID-alternate L-selenocystine RESID-name Sec2 PSI-MOD-label selenium cystine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 Se 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 2 Se 2 MassAvg 298.08 MassMono 299.891620 Origin U, U Source hypothetical TermSpec none MOD:00692 MOD:01158 PSI-MOD MOD:01184 L-selenocystine (selenium disubstituted L-cystine) A protein modification that effectively substitutes two selenium atoms for two sulfur atoms in L-cystine to form L-selenocystine. 17715293 PubMed AA0437#CYS2 RESID Cross-link 2; for formation of the same modification by oxidation of two L-selenocysteine residues, see MOD:01183. (R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid) RESID-systematic 3,3'-diselenobis(2-aminopropanoic acid) RESID-alternate 3,3'-diselenobisalanine RESID-alternate 3,3'-diselenodialanine RESID-alternate beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide RESID-alternate beta,beta'-diselenodialanine RESID-alternate bis(alpha-aminopropionic acid)-beta-diselenide RESID-alternate bis(beta-amino-beta-carboxyethyl)diselenide RESID-alternate CROSSLNK Selenocystine (Sec-Sec) UniProt-feature diselenocysteine RESID-alternate L-selenocystine RESID-name Se2(S2)Cys2 PSI-MOD-label selenium cystine RESID-alternate DiffAvg 91.81 DiffFormula C 0 H -2 N 0 O 0 S -2 Se 2 DiffMono 93.873250 Formula C 6 H 8 N 2 O 2 Se 2 MassAvg 298.08 MassMono 299.891620 Origin C, C Source hypothetical TermSpec none MOD:00007 MOD:00905 PSI-MOD MOD:01185 4-amidated L-aspartic acid A protein modification that effectively converts an L-aspartic acid residue to L-asparagine. 17962566 PubMed AA0003#ASP RESID (2S)-2-amino-4-butanediamic acid RESID-systematic 2,4-bis(azanyl)-4-oxobutanoic acid RESID-alternate 2,4-diamino-4-oxobutanoic acid RESID-alternate 2-amino-3-carbamoylpropanoic acid RESID-alternate 2-amino-4-butanediamic acid RESID-alternate 2-aminosuccinamic acid RESID-alternate 2-aminosuccinic acid 4-amide RESID-alternate 4NAsp PSI-MOD-label alpha-amino-beta-carbamylpropionic acid RESID-alternate alpha-aminosuccinamic acid RESID-alternate aspartic acid 4-amide RESID-alternate aspartic acid beta-amide RESID-alternate beta-asparagine RESID-alternate L-asparagine RESID-name MOD_RES Amidated aspartic acid UniProt-feature DiffAvg -0.98 DiffFormula C 0 H 1 N 1 O -1 DiffMono -0.984016 Formula C 4 H 6 N 2 O 2 MassAvg 114.10 MassMono 114.042927 Origin D Source natural TermSpec none MOD:00012 MOD:00674 MOD:00904 PSI-MOD MOD:01186 acetylated L-threonine A protein modification that effectively converts an L-threonine residue to either N-acetyl-L-threonne, or O-acetyl-Lthreonine. 18688235 PubMed PSI-MOD-slim AcThr PSI-MOD-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula none MassAvg none MassMono none Origin T Source natural MOD:00394 MOD:00917 PSI-MOD MOD:01187 L-pyrrolysine residue A protein modification that inserts or replaces a residue with an L-pyrrolysine residue, a natural pretranslational modification. 21860 ChEBI 11435424 PubMed 12029131 PubMed 12029132 PubMed 15314242 PubMed 16096277 PubMed AA0321 RESID 435 UniMod PSI-MOD-slim (2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid RESID-systematic 2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid RESID-alternate L-pyrrolysine RESID-name monomethylamine methyltransferase cofactor lysine adduct RESID-alternate N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine RESID-alternate N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine RESID-alternate N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine RESID-alternate NON_STD Pyrrolysine UniProt-feature Pyl PSI-MOD-label DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 12 H 19 N 3 O 2 MassAvg 237.30 MassMono 237.147727 Origin O Source natural TermSpec none MOD:00868 PSI-MOD MOD:01188 N-ethyl iodoacetamide-d5 - site Y modification from UniMod Isotopic label - 11710128 PubMed 12766232 PubMed 3155470 PubMed 957432 PubMed 212#Y UniMod N-ethyl iodoacetamide-d5 UniMod-description NEIAA:2H(5) PSI-MS-label DiffAvg 90.08 DiffFormula C 4 (1)H 2 (2)H 5 N 1 O 1 DiffMono 90.084148 Formula C 13 (1)H 11 (2)H 5 N 2 O 3 MassAvg 253.15 MassMono 253.147476 Origin Y Source artifact TermSpec none MOD:00562 PSI-MOD MOD:01189 N-ethyl iodoacetamide-d5 - site C modification from UniMod Isotopic label - 12766232 PubMed 212#C UniMod N-ethyl iodoacetamide-d5 UniMod-description NEIAA:2H(5) PSI-MS-label DiffAvg 90.08 DiffFormula C 4 (1)H 2 (2)H 5 N 1 O 1 DiffMono 90.084148 Formula C 7 (1)H 7 (2)H 5 N 2 O 2 S 1 MassAvg 193.09 MassMono 193.093332 Origin C Source artifact TermSpec none MOD:00562 PSI-MOD MOD:01190 dibromo Modification from UniMod Chemical derivative. OBSOLETE because duplicate and redundant with MOD:01006. Remap to MOD:01006. 534 UniMod Dibromo PSI-MS-label Dibromo UniMod-description DiffAvg 157.79 DiffFormula Br 2 H -2 DiffMono 155.821024 Formula none MassAvg none MassMono none Origin Y Source none TermSpec none 1 PSI-MOD MOD:01191 N-ethyl iodoacetamide-d0 - site C modification from UniMod Isotopic label - 12766232 PubMed 211#C UniMod N-ethyl iodoacetamide-d0 UniMod-description NEIAA PSI-MS-label DiffAvg 85.11 DiffFormula C 4 H 7 N 1 O 1 DiffMono 85.052764 Formula C 7 H 12 N 2 O 2 S 1 MassAvg 188.25 MassMono 188.061949 Origin C Source artifact TermSpec none MOD:00561 PSI-MOD MOD:01192 N-ethyl iodoacetamide-d0 - site Y modification from UniMod Isotopic label - 11760118 PubMed 12766232 PubMed 211#Y UniMod N-ethyl iodoacetamide-d0 UniMod-description NEIAA PSI-MS-label DiffAvg 85.11 DiffFormula C 4 H 7 N 1 O 1 DiffMono 85.052764 Formula C 13 H 16 N 2 O 3 MassAvg 248.28 MassMono 248.116092 Origin Y Source artifact TermSpec none MOD:00561 PSI-MOD MOD:01193 phosphorylation to pyridyl thiol - site T modification from UniMod Chemical derivative - 1093385 PubMed 264#T UniMod PET PSI-MS-label phosphorylation to pyridyl thiol UniMod-description DiffAvg 121.20 DiffFormula C 7 H 7 N 1 O -1 S 1 DiffMono 121.035006 Formula C 11 H 14 N 2 O 1 S 1 MassAvg 222.31 MassMono 222.082684 Origin T Source artifact TermSpec none MOD:00586 PSI-MOD MOD:01194 phosphorylation to pyridyl thiol - site S modification from UniMod Chemical derivative - 15279557 PubMed 264#S UniMod PET PSI-MS-label phosphorylation to pyridyl thiol UniMod-description DiffAvg 121.20 DiffFormula C 7 H 7 N 1 O -1 S 1 DiffMono 121.035006 Formula C 10 H 12 N 2 O 1 S 1 MassAvg 208.28 MassMono 208.067034 Origin S Source artifact TermSpec none MOD:00586 PSI-MOD MOD:01195 benzoyl labeling reagent light form - site K modification from UniMod Isotopic label - 11813307 PubMed 12777388 PubMed 15456300 PubMed 136#K UniMod Benzoyl PSI-MS-label labeling reagent light form (N-term & K) UniMod-description DiffAvg 104.11 DiffFormula C 7 H 4 O 1 DiffMono 104.026215 Formula C 13 H 16 N 2 O 2 MassAvg 232.28 MassMono 232.121178 Origin K Source artifact TermSpec none MOD:00505 PSI-MOD MOD:01196 5-dimethylaminonaphthalene-1-sulfonyl - site K OBSOLETE because redundant, replaced with MOD:01654. Remap to MOD:01654. 139 UniMod 5-dimethylaminonaphthalene-1-sulfonyl UniMod-description Dansyl PSI-MS-label DiffAvg 233.29 DiffFormula C 12 H 11 N 1 O 2 S 1 DiffMono 233.051050 Formula C 18 H 23 N 3 O 3 S 1 MassAvg 361.46 MassMono 361.146013 Origin K Source artifact TermSpec none 1 PSI-MOD MOD:01197 N-heptosyl-L-glutamine A protein modification that effectively converts an L-glutamine residue to N-heptosyl-L-glutamine. 490#Q UniMod From UniMod with no citation [JSG]. Hep PSI-MS-label Heptose UniMod-description DiffAvg 192.17 DiffFormula C 7 H 12 O 6 DiffMono 192.063388 Formula C 12 H 20 N 2 O 8 MassAvg 320.30 MassMono 320.121966 Origin Q Source artifact TermSpec none MOD:00925 PSI-MOD MOD:01198 O-heptosyl-L-serine A protein modification that effectively converts an L-serine residue to O-heptosyl-L-serine. 490#S UniMod From UniMod with no citation [JSG]. Hep PSI-MS-label Heptose UniMod-description DiffAvg 192.17 DiffFormula C 7 H 12 O 6 DiffMono 192.063388 Formula C 10 H 17 N 1 O 8 MassAvg 279.25 MassMono 279.095417 Origin S Source artifact TermSpec none MOD:00925 PSI-MOD MOD:01199 N-heptosyl-L-arginine A protein modification that effectively converts an L-arginine residue to an N-heptosyl-L-arginine. 490#R UniMod From UniMod with no citation [JSG]. Hep PSI-MS-label Heptose UniMod-description DiffAvg 192.17 DiffFormula C 7 H 12 O 6 DiffMono 192.063388 Formula C 13 H 24 N 4 O 7 MassAvg 348.36 MassMono 348.164499 Origin R Source artifact TermSpec none MOD:00925 PSI-MOD MOD:01200 O-heptosyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-heptosyl-L-threonine. 490#T UniMod From UniMod with no citation [JSG]. Hep PSI-MS-label Heptose UniMod-description DiffAvg 192.17 DiffFormula C 7 H 12 O 6 DiffMono 192.063388 Formula C 11 H 19 N 1 O 8 MassAvg 293.27 MassMono 293.111067 Origin T Source artifact TermSpec none MOD:00925 PSI-MOD MOD:01201 N6-heptosyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-heptosyl-L-lysine. 490#K UniMod From UniMod with no citation [JSG]. Hep PSI-MS-label Heptose UniMod-description DiffAvg 192.17 DiffFormula C 7 H 12 O 6 DiffMono 192.063388 Formula C 13 H 24 N 2 O 7 MassAvg 320.34 MassMono 320.158351 Origin K Source artifact TermSpec none MOD:00925 PSI-MOD MOD:01202 N-heptosyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N-heptosyl-L-asparagine. 490#N UniMod From UniMod with no citation [JSG]. Hep PSI-MS-label Heptose UniMod-description DiffAvg 192.17 DiffFormula C 7 H 12 O 6 DiffMono 192.063388 Formula C 11 H 18 N 2 O 8 MassAvg 306.27 MassMono 306.106316 Origin N Source artifact TermSpec none MOD:00925 PSI-MOD MOD:01203 N6-(pyridylacetyl)lysine A protein modification that effectively converts an L-lysine residue to N6-[(pyrid-3-yl)acetyl]lysine. 9276974 PubMed 25#K UniMod Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. Pyridylacetyl PSI-MS-label pyridylacetyl UniMod-description DiffAvg 119.12 DiffFormula C 7 H 5 N 1 O 1 DiffMono 119.037114 Formula C 13 H 17 N 3 O 2 MassAvg 247.30 MassMono 247.132077 Origin K Source artifact TermSpec none MOD:00418 MOD:01875 PSI-MOD MOD:01204 prompt loss of methanethiol from oxidixed methionine modification from UniMod Artifact - 9004526 PubMed 526 UniMod Dethiomethyl PSI-MS-label Prompt loss of side chain from oxidised Met UniMod-description DiffAvg -48.10 DiffFormula C -1 H -4 S -1 DiffMono -48.003371 Formula C 4 H 5 N 1 O 1 S 0 MassAvg 83.09 MassMono 83.037114 Origin M Source artifact TermSpec none MOD:00913 PSI-MOD MOD:01205 Hex1HexNAc1NeuAc2 O-glycosylated serine A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. 7949339 PubMed 160#S UniMod Hex(1)HexNAc(1)NeuAc(2) PSI-MS-label Hex1HexNAc1NeuAc2 UniMod-description DiffAvg 947.85 DiffFormula C 36 H 57 N 3 O 26 DiffMono 947.323029 Formula C 39 H 62 N 4 O 28 MassAvg 1034.93 MassMono 1034.355057 Origin S Source natural TermSpec none MOD:00528 MOD:00916 PSI-MOD MOD:01206 Hex1HexNAc1NeuAc2 O-glycosylated threonine A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. 160#T UniMod Hex(1)HexNAc(1)NeuAc(2) PSI-MS-label Hex1HexNAc1NeuAc2 UniMod-description DiffAvg 947.85 DiffFormula C 36 H 57 N 3 O 26 DiffMono 947.323029 Formula C 40 H 64 N 4 O 28 MassAvg 1048.95 MassMono 1048.370707 Origin T Source natural TermSpec none MOD:00528 MOD:00917 PSI-MOD MOD:01207 Hex1HexNAc1NeuAc2 N4-glycosylated asparagine A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. 160#N UniMod Hex(1)HexNAc(1)NeuAc(2) PSI-MS-label Hex1HexNAc1NeuAc2 UniMod-description DiffAvg 947.85 DiffFormula C 36 H 57 N 3 O 26 DiffMono 947.323029 Formula C 40 H 63 N 5 O 28 MassAvg 1061.95 MassMono 1061.365956 Origin N Source natural TermSpec none MOD:00528 MOD:00903 PSI-MOD MOD:01208 copper(1+) carboxylate C-terminal residue A protein modification that effectively converts a C-terminal residue to the copper(1+) carboxylate salt. 531#C-term UniMod Cation:Cu[I] PSI-MS-label cuprous salt PSI-MOD-alternate Replacement of proton by copper UniMod-description DiffAvg 62.54 DiffFormula Cu 1 H -1 DiffMono 61.921772 Formula none MassAvg none MassMono none Origin X Source none TermSpec C-term MOD:00742 PSI-MOD MOD:01209 copper(1+) L-aspartate A protein modification that effectively converts an L-aspartic acid residue to the copper(1+) aspartate salt. 531#D UniMod Cation:Cu[I] PSI-MS-label cuprous salt PSI-MOD-alternate Replacement of proton by copper UniMod-description DiffAvg 62.54 DiffFormula Cu 1 H -1 DiffMono 61.921772 Formula C 4 Cu 1 H 4 N 1 O 3 MassAvg 177.63 MassMono 176.948715 Origin D Source none TermSpec none MOD:00742 MOD:00904 PSI-MOD MOD:01210 copper(1+) L-glutamate A protein modification that effectively converts an L-glutamic acid residue to the copper(1+) glutamate salt. 531#E UniMod Cation:Cu[I] PSI-MS-label cuprous salt PSI-MOD-alternate Replacement of proton by copper UniMod-description DiffAvg 62.54 DiffFormula Cu 1 H -1 DiffMono 61.921772 Formula C 5 Cu 1 H 6 N 1 O 3 MassAvg 191.65 MassMono 190.964366 Origin E Source none TermSpec none MOD:00742 MOD:00906 PSI-MOD MOD:01211 N6-(morpholine-2-acetyl)-lysine A protein modification that effectively converts an L-lysine residue to N6-(morpholine-2-acetyl)-lysine. 10446193 PubMed 29#K UniMod The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. N-Succinimidyl-2-morpholine acetate UniMod-description N-succinimidylmorpholine-2-acetate N6-derivatized lysine PSI-MOD-alternate SMA PSI-MS-label DiffAvg 127.14 DiffFormula C 6 H 9 N 1 O 2 DiffMono 127.063329 Formula C 12 H 21 N 3 O 3 MassAvg 255.32 MassMono 255.158292 Origin K Source artifact TermSpec none MOD:01813 MOD:01875 PSI-MOD MOD:01212 iodoacetamide N6-derivatized lysine A protein modification that effectively converts an L-lysine residue to N6-(carboxamidomethyl)lysine. 11510821 PubMed 12422359 PubMed 12686488 PubMed 4#K UniMod PSI-MOD-slim Carbamidomethyl PSI-MS-label carbamidomethylk OMSSA-label Iodoacetamide derivative UniMod-description N6-(2-amino-2-oxoethyl)lysine PSI-MOD-alternate N6-(carbamoylmethyl)lysine PSI-MOD-alternate DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula C 8 H 15 N 3 O 2 MassAvg 185.23 MassMono 185.116427 Origin K Source artifact TermSpec none MOD:00397 MOD:00912 PSI-MOD MOD:01213 iodoacetamide derivatized histidine A protein modification that effectively converts an L-histidine residue to an iodoacetamide derivatized histidine, either 1'- or 3'-(carboxamidolmethyl)histidine. 11510821 PubMed 12422359 PubMed 15627961 PubMed 2026710 PubMed 4#H UniMod PSI-MOD-slim Carbamidomethyl PSI-MS-label carbamidometylh OMSSA-label Iodoacetamide derivative UniMod-description DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula C 8 H 10 N 4 O 2 MassAvg 194.19 MassMono 194.080376 Origin H Source artifact TermSpec none MOD:00397 MOD:00909 PSI-MOD MOD:01214 iodoacetamide - site C modification from UniMod Chemical derivative - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060. 10504701 PubMed 11510821 PubMed 12422359 PubMed 4#C UniMod Carbamidomethyl PSI-MS-label Iodoacetamide derivative UniMod-description DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none 1 PSI-MOD MOD:01215 iodoacetamide derivatized aspartic acid A protein modification that effectively converts an L-aspartic acid residue to O4-(carboxamidomethyl)aspartate. 11510821 PubMed 12422359 PubMed 16526082 PubMed 4#D UniMod PSI-MOD-slim Carbamidomethyl PSI-MS-label carbamidomethyld OMSSA-label Iodoacetamide derivative UniMod-description DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula C 6 H 8 N 2 O 4 MassAvg 172.14 MassMono 172.048407 Origin D Source artifact TermSpec none MOD:00397 MOD:00904 PSI-MOD MOD:01216 iodoacetamide derivatized glutamic acid A protein modification that effectively converts an L-glutamic acid residue to O5-(carboxamidomethyl)glutamate. 11510821 PubMed 12422359 PubMed 4#E UniMod PSI-MOD-slim Carbamidomethyl PSI-MS-label carbamidomethyle OMSSA-label Iodoacetamide derivative UniMod-description DiffAvg 57.05 DiffFormula C 2 H 3 N 1 O 1 DiffMono 57.021464 Formula C 7 H 10 N 2 O 4 MassAvg 186.17 MassMono 186.064057 Origin E Source artifact TermSpec none MOD:00397 MOD:00906 PSI-MOD MOD:01217 Sulfanilic Acid (SA), light C12 - site D modification from UniMod Isotopic label - 12872131 PubMed 285#D UniMod Light Sulfanilic Acid (SA) C12 UniMod-description SulfanilicAcid PSI-MS-label DiffAvg 155.00 DiffFormula (12)C 6 H 5 N 1 O 2 S 1 DiffMono 155.004099 Formula (12)C 10 H 10 N 2 O 5 S 1 MassAvg 270.03 MassMono 270.031042 Origin D Source artifact TermSpec none MOD:00605 PSI-MOD MOD:01218 Sulfanilic Acid (SA), light C12 - site E modification from UniMod Isotopic label - 15283597 PubMed 285#E UniMod Light Sulfanilic Acid (SA) C12 UniMod-description SulfanilicAcid PSI-MS-label DiffAvg 155.00 DiffFormula (12)C 6 H 5 N 1 O 2 S 1 DiffMono 155.004099 Formula (12)C 11 H 12 N 2 O 5 S 1 MassAvg 284.05 MassMono 284.046692 Origin E Source artifact TermSpec none MOD:00605 PSI-MOD MOD:01219 Sulfanilic Acid (SA), heavy C13 - site D modification from UniMod Chemical derivative - 9254591 PubMed 9750125 PubMed 286#D UniMod Heavy Sulfanilic Acid (SA) C13 UniMod-description SulfanilicAcid:13C(6) PSI-MS-label DiffAvg 161.02 DiffFormula (13)C 6 H 5 N 1 O 2 S 1 DiffMono 161.024228 Formula (12)C 4 (13)C 6 H 10 N 2 O 5 S 1 MassAvg 276.05 MassMono 276.051171 Origin D Source artifact TermSpec none MOD:00606 PSI-MOD MOD:01220 Sulfanilic Acid (SA), heavy C13 - site E modification from UniMod Chemical derivative - 15121203 PubMed 9254591 PubMed 286#E UniMod Heavy Sulfanilic Acid (SA) C13 UniMod-description SulfanilicAcid:13C(6) PSI-MS-label DiffAvg 161.02 DiffFormula (13)C 6 H 5 N 1 O 2 S 1 DiffMono 161.024228 Formula (12)C 5 (13)C 6 H 12 N 2 O 5 S 1 MassAvg 290.07 MassMono 290.066822 Origin E Source artifact TermSpec none MOD:00606 PSI-MOD MOD:01221 O-formyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-formyl-L-threonine. 11861642 PubMed 15799070 PubMed 122#T UniMod From UniMod: Can occur under CNBr cleavage conditions (70% HCOOH). Formyl PSI-MS-label Formylation UniMod-description DiffAvg 28.01 DiffFormula C 1 O 1 DiffMono 27.994915 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin T Source artifact TermSpec none MOD:00917 MOD:01483 PSI-MOD MOD:01222 O-formyl-L-serine A protein modification that effectively converts an L-serine residue to O-formyl-L-serine. 15627961 PubMed 15799070 PubMed 122#S UniMod From UniMod: Can occur under CNBr cleavage conditions (70% HCOOH). Formyl PSI-MS-label Formylation UniMod-description DiffAvg 28.01 DiffFormula C 1 O 1 DiffMono 27.994915 Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin S Source artifact TermSpec none MOD:00916 MOD:01483 PSI-MOD MOD:01223 thioacylation of primary amines - site N-term modification from UniMod Other - 11710128 PubMed 3155470 PubMed 957432 PubMed 126#N-term UniMod This UniMod entry is misdescribed as "thioacylation" [JSG]. 3,3-Dithio-bis-(sulfosuccinimidyl)propionate UniMod-alternate ntermpeptioacetyl OMSSA-label Thioacyl PSI-MS-label thioacylation of primary amines (N-term and Lys) UniMod-description DiffAvg 88.12 DiffFormula C 3 H 4 O 1 S 1 DiffMono 87.998286 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00497 PSI-MOD MOD:01224 thioacylation of primary amines - site K modification from UniMod Other - 11710128 PubMed 3155470 PubMed 957432 PubMed 126#K UniMod This UniMod entry is misdescribed as "thioacylation" [JSG]. 3,3-Dithio-bis-(sulfosuccinimidyl)propionate UniMod-alternate thioacetylk OMSSA-label Thioacyl PSI-MS-label thioacylation of primary amines (N-term and Lys) UniMod-description DiffAvg 88.12 DiffFormula C 3 H 4 O 1 S 1 DiffMono 87.998286 Formula C 9 H 16 N 2 O 2 S 1 MassAvg 216.30 MassMono 216.093249 Origin K Source artifact TermSpec none MOD:00497 PSI-MOD MOD:01225 monofluorinated L-tyrosine A protein modification that effectively converts an L-tyrosine residue into an L-fluorotyrosine. 8069568 PubMed 127#Y UniMod From UniMod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. Fluoro PSI-MS-label fluorophenylalanine replacement of phenylalanine UniMod-description phef OMSSA-label DiffAvg 17.99 DiffFormula F 1 H -1 DiffMono 17.990578 Formula C 9 F 1 H 8 N 1 O 2 MassAvg 181.17 MassMono 181.053907 Origin Y Source artifact TermSpec none MOD:00498 MOD:00985 PSI-MOD MOD:01226 monofluorinated L-tryptophan A protein modification that effectively converts an L-tryptophan residue to an L-fluorotryptophan. 8069568 PubMed 127#W UniMod From UniMod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. Fluoro PSI-MS-label fluorophenylalanine replacement of phenylalanine UniMod-description DiffAvg 17.99 DiffFormula F 1 H -1 DiffMono 17.990578 Formula C 11 F 1 H 9 N 2 O 1 MassAvg 204.20 MassMono 204.069891 Origin W Source artifact TermSpec none MOD:00498 MOD:01068 PSI-MOD MOD:01227 monofluorinated L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to an L-fluorophenylalanine. 181 DeltaMass 8069568 PubMed 127#F UniMod From UniMod: the citation appears to be correct, but the PMID is not and has been corrected. From DeltaMass: (element abbreviation in formula incorrect, mass incorrect, and aggregate not delta) Average Mass: 149 Formula: C9H8O1N1Fl1 Average Mass Change: 149 References:PE Sciex with no citation [JSG]. Fluoro PSI-MS-label fluorophenylalanine replacement of phenylalanine UniMod-description phef OMSSA-label DiffAvg 17.99 DiffFormula C 0 F 1 H -1 N 0 O 0 DiffMono 17.990578 Formula C 9 F 1 H 8 N 1 O 1 MassAvg 165.17 MassMono 165.058992 Origin F Source artifact TermSpec none MOD:00498 MOD:01066 PSI-MOD MOD:01228 monoiodinated tyrosine A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one iodine atom. 0 DeltaMass 1326520 PubMed 15627961 PubMed 2026710 PubMed 129#Y UniMod From DeltaMass: Average Mass: 289 [name misspelled "monoiodated" - JSG]. PSI-MOD-slim I1Tyr PSI-MOD-label Iodination UniMod-description iodinationy OMSSA-label Iodo PSI-MS-label DiffAvg 125.90 DiffFormula H -1 I 1 DiffMono 125.896648 Formula C 9 H 8 I 1 N 1 O 2 MassAvg 289.07 MassMono 288.959976 Origin Y Source artifact TermSpec none MOD:00500 MOD:00998 PSI-MOD MOD:01229 L-iodohistidine A protein modification that effectively converts an L-histidine residue to an L-iodohistidine. 15627961 PubMed 2026710 PubMed 129#H UniMod I1His PSI-MOD-label Iodination UniMod-description Iodo PSI-MS-label DiffAvg 125.90 DiffFormula C 0 H -1 I 1 N 0 O 0 DiffMono 125.896648 Formula C 6 H 6 I 1 N 3 O 1 MassAvg 263.04 MassMono 262.955560 Origin H Source artifact TermSpec none MOD:00500 MOD:01049 PSI-MOD MOD:01230 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form - site K modification from UniMod Isotopic label - 15602776 PubMed 365#K UniMod Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form UniMod-description ICPL PSI-MS-label DiffAvg 105.02 DiffFormula (12)C 6 H 3 N 1 O 1 DiffMono 105.021464 Formula (12)C 12 H 15 N 3 O 2 MassAvg 233.12 MassMono 233.116427 Origin K Source artifact TermSpec none MOD:00790 PSI-MOD MOD:01231 3x(13)C labeled N6-propanoyl-L-lysine A protein modification that effectively converts an L-lysine residue to 3x(13)C labeled N6-propanoyl-L-lysine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 12442261 PubMed 59#K UniMod PSI-MOD-slim Propionate labeling reagent heavy form (+3amu), N-term & K UniMod-description Propionyl:13C(3) PSI-MS-label DiffAvg 59.04 DiffFormula (13)C 3 H 4 O 1 DiffMono 59.036279 Formula (12)C 6 (13)C 3 H 16 N 2 O 2 MassAvg 187.13 MassMono 187.131242 Origin K Source artifact TermSpec none MOD:01398 PSI-MOD MOD:01232 3x(12)C labeled N6-propanoyl-L-lysine A protein modification that effectively converts an L-lysine residue to 3x(12)C labeled N6-propanoyl-L-lysine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 58#K UniMod PSI-MOD-slim Propionate labeling reagent light form (N-term & K) UniMod-description Propionyl PSI-MS-label DiffAvg 56.03 DiffFormula (12)C 3 H 4 O 1 DiffMono 56.026215 Formula (12)C 9 H 16 N 2 O 2 MassAvg 184.12 MassMono 184.121178 Origin K Source artifact TermSpec none MOD:01398 PSI-MOD MOD:01233 3x(2)H labeled N6-acetyl-L-lysine A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled N6-acetyl-L-lysine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 56#K UniMod PSI-MOD-slim Acetate labeling reagent (N-term & K) (heavy form, +3amu) UniMod-description Acetyl:2H(3) PSI-MS-label DiffAvg 45.03 DiffFormula C 2 (1)H -1 (2)H 3 O 1 DiffMono 45.029395 Formula C 8 (1)H 11 (2)H 3 N 2 O 2 MassAvg 173.12 MassMono 173.124358 Origin K Source artifact TermSpec none MOD:00064 MOD:00449 PSI-MOD MOD:01234 (18)O monosubstituted L-serine modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate 11467524 PubMed 258#S UniMod PSI-MOD-slim Label:18O(1) PSI-MS-label O18 Labeling UniMod-description DiffAvg 2.00 DiffFormula (16)O -1 (18)O 1 DiffMono 2.004246 Formula C 3 H 5 N 1 (16)O 1 (18)O 1 MassAvg 89.04 MassMono 89.036275 Origin S Source artifact TermSpec none MOD:00581 MOD:00916 PSI-MOD MOD:01235 (18)O monosubstituted L-threonine modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate 11467524 PubMed 15549660 PubMed 258#T UniMod PSI-MOD-slim Label:18O(1) PSI-MS-label O18 Labeling UniMod-description DiffAvg 2.00 DiffFormula (16)O -1 (18)O 1 DiffMono 2.004246 Formula C 4 H 7 N 1 (16)O 1 (18)O 1 MassAvg 103.05 MassMono 103.051925 Origin T Source artifact TermSpec none MOD:00581 MOD:00917 PSI-MOD MOD:01236 (18)O monosubstituted L-tyrosine modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate 11467524 PubMed 15549660 PubMed 258#Y UniMod PSI-MOD-slim Label:18O(1) PSI-MS-label O18 Labeling UniMod-description DiffAvg 2.00 DiffFormula (16)O -1 (18)O 1 DiffMono 2.004246 Formula C 9 H 9 N 1 (16)O 1 (18)O 1 MassAvg 165.07 MassMono 165.067575 Origin Y Source artifact TermSpec none MOD:00581 MOD:00919 PSI-MOD MOD:01237 cysteine 4-hydroxynonenal adduct A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal. 11327326 PubMed 15133838 PubMed 9629898 PubMed 53#C UniMod 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. 4-hydroxynonenal (HNE) UniMod-description HNE PSI-MS-label DiffAvg 156.22 DiffFormula C 9 H 16 O 2 DiffMono 156.115030 Formula C 12 H 21 N 1 O 3 S 1 MassAvg 259.36 MassMono 259.124215 Origin C Source artifact TermSpec none MOD:00446 PSI-MOD MOD:01238 lysine 4-hydroxynonenal adduct A protein modification produced by formation of an adduct of an L-lysine residue with 4-hydroxynonenal. 11327326 PubMed 15133838 PubMed 9629898 PubMed 53#K UniMod 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. 4-hydroxynonenal (HNE) UniMod-description HNE PSI-MS-label DiffAvg 156.22 DiffFormula C 9 H 16 O 2 DiffMono 156.115030 Formula C 15 H 28 N 2 O 3 MassAvg 284.40 MassMono 284.209993 Origin K Source artifact TermSpec none MOD:00446 PSI-MOD MOD:01239 histidine 4-hydroxynonenal adduct A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal. 10717661 PubMed 11327326 PubMed 15133838 PubMed 53#H UniMod 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. 4-hydroxynonenal (HNE) UniMod-description HNE PSI-MS-label DiffAvg 156.22 DiffFormula C 9 H 16 O 2 DiffMono 156.115030 Formula C 15 H 23 N 3 O 3 MassAvg 293.37 MassMono 293.173942 Origin H Source artifact TermSpec none MOD:00446 PSI-MOD MOD:01240 ubiquitination signature tetrapeptidyl lysine A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of leucyl-arginyl-glycyl-glycine, the C-terminal tetrapeptide of ubiquitin. 10504701 PubMed 535 UniMod LeuArgGlyGly PSI-MS-label Ubiquitination UniMod-description DiffAvg 383.45 DiffFormula C 16 H 29 N 7 O 4 DiffMono 383.228102 Formula C 22 H 41 N 9 O 5 MassAvg 511.63 MassMono 511.323065 Origin K Source artifact TermSpec none MOD:00908 MOD:01875 derives_from MOD:011480 PSI-MOD MOD:01241 3x(2)H labeled L-aspartic acid 4-methyl ester A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-aspartic acid 4-methyl ester. 12185208 PubMed 298#D UniMod deuterated methyl ester UniMod-description Methyl:2H(3) PSI-MS-label trideuteromethyld OMSSA-label DiffAvg 17.03 DiffFormula C 1 (1)H -1 (2)H 3 DiffMono 17.034480 Formula C 5 (1)H 4 (2)H 3 N 1 O 3 MassAvg 132.06 MassMono 132.061423 Origin D Source artifact TermSpec none MOD:00617 MOD:00904 derives_from MOD:011810 PSI-MOD MOD:01242 3x(2)H labeled L-glutamic acid 5-methyl ester A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-glutamic acid 5-methyl ester. 1326520 PubMed 298#E UniMod deuterated methyl ester UniMod-description Methyl:2H(3) PSI-MS-label trideuteromethyle OMSSA-label DiffAvg 17.03 DiffFormula C 1 (1)H -1 (2)H 3 DiffMono 17.034480 Formula C 6 (1)H 6 (2)H 3 N 1 O 3 MassAvg 146.08 MassMono 146.077073 Origin E Source artifact TermSpec none MOD:00617 MOD:00906 derives_from MOD:000810 PSI-MOD MOD:01243 potassium carboxylate C-terminal residue A protein modification that effectively converts a C-terminal residue to the potassium carboxylate salt. 530#C-term UniMod Cation:K PSI-MS-label Replacement of proton by potassium UniMod-description DiffAvg 38.09 DiffFormula H -1 K 1 DiffMono 37.955882 Formula none MassAvg none MassMono none Origin X Source none TermSpec C-term MOD:01072 PSI-MOD MOD:01244 potassium L-glutamate A protein modification that effectively converts an L-glutamioc acid residue to the potassium glutamate salt. 530#E UniMod Cation:K PSI-MS-label Replacement of proton by potassium UniMod-description DiffAvg 38.09 DiffFormula H -1 K 1 DiffMono 37.955882 Formula C 5 H 6 K 1 N 1 O 3 MassAvg 167.21 MassMono 166.998475 Origin E Source none TermSpec none MOD:00906 MOD:01072 PSI-MOD MOD:01245 potassium L-aspartate A protein modification that effectively converts an L-aspartic acid residue to the potassium aspartate salt. 530#D UniMod Cation:K PSI-MS-label Replacement of proton by potassium UniMod-description DiffAvg 38.09 DiffFormula H -1 K 1 DiffMono 37.955882 Formula C 4 H 4 K 1 N 1 O 3 MassAvg 153.18 MassMono 152.982825 Origin D Source none TermSpec none MOD:00904 MOD:01072 PSI-MOD MOD:01246 fucosylated -site S OBSOLETE because redundant and identical to MOD:00812 after formula correction. Remap to MOD:00812. 11344537 PubMed 15189151 PubMed 3311742 PubMed 3578767 PubMed 295#S UniMod dHex PSI-MS-label Fucose UniMod-description DiffAvg 147.15 DiffFormula C 6 H 11 O 4 DiffMono 147.065734 Formula C 9 H 16 N 1 O 6 MassAvg 234.23 MassMono 234.097762 Origin S Source natural TermSpec none 1 PSI-MOD MOD:01247 fucosylated -site T OBSOLETE because redundant and identical to MOD:00813 after formula correction. Remap to MOD:00813. 11344537 PubMed 11857757 PubMed 15189151 PubMed 295#T UniMod dHex PSI-MS-label Fucose UniMod-description DiffAvg 147.15 DiffFormula C 6 H 11 O 4 DiffMono 147.065734 Formula C 10 H 18 N 1 O 6 MassAvg 248.26 MassMono 248.113412 Origin T Source natural TermSpec none 1 PSI-MOD MOD:01248 iodouridine monophosphate derivatized tyrosine A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tyrosine residue to form an ether linkage. 11112526 PubMed 11567090 PubMed 6540775 PubMed 292#Y UniMod This has an ether linkage and not a phosphodiester linkage with UMP. Cross-link of (Iodo)-uracil MP with W,F,Y UniMod-description IodoU-AMP PSI-MS-label DiffAvg 322.17 DiffFormula C 9 H 11 N 2 O 9 P 1 DiffMono 322.020217 Formula C 18 H 20 N 3 O 11 P 1 MassAvg 485.34 MassMono 485.083545 Origin Y Source artifact TermSpec none MOD:00611 MOD:00919 PSI-MOD MOD:01249 iodouridine monophosphate derivatized tryptophan A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tryptophan residue. 11112526 PubMed 11567090 PubMed 6540775 PubMed 292#W UniMod This has a carbon-nitrogen linkage and not a phosphodiester linkage with UMP. Cross-link of (Iodo)-uracil MP with W,F,Y UniMod-description IodoU-AMP PSI-MS-label DiffAvg 322.17 DiffFormula C 9 H 11 N 2 O 9 P 1 DiffMono 322.020217 Formula C 20 H 21 N 4 O 10 P 1 MassAvg 508.38 MassMono 508.099530 Origin W Source artifact TermSpec none MOD:00611 MOD:00918 PSI-MOD MOD:01250 iodouridine monophosphate derivatized phenylalanine A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-phenylalanine residue. 11112526 PubMed 11567090 PubMed 6540775 PubMed 292#F UniMod This has a carbon-carbon linkage and not a phosphodiester linkage with UMP. Cross-link of (Iodo)-uracil MP with W,F,Y UniMod-description IodoU-AMP PSI-MS-label DiffAvg 322.17 DiffFormula C 9 H 11 N 2 O 9 P 1 DiffMono 322.020217 Formula C 18 H 20 N 3 O 10 P 1 MassAvg 469.34 MassMono 469.088630 Origin F Source artifact TermSpec none MOD:00611 MOD:00914 PSI-MOD MOD:01251 N6-[3-(carboxamidomethylthio)propanoyl]lysine A protein modification that effectively converts an L-lysine residue to N6-[3-(carboxamidomethylthio)propanoyl]lysine. 15121203 PubMed 293#K UniMod 3-(carbamidomethylthio)propanoyl UniMod-description CAMthiopropanoyl PSI-MS-label DiffAvg 145.18 DiffFormula C 5 H 7 N 1 O 2 S 1 DiffMono 145.019749 Formula C 11 H 19 N 3 O 3 S 1 MassAvg 273.35 MassMono 273.114712 Origin K Source artifact TermSpec none MOD:00612 MOD:01875 PSI-MOD MOD:01252 5-hydro-5-methylimidazol-4-one, methylglyoxal arginine adduct (+54 amu) OBSOLETE because redundant and identical to MOD:00933. Remap to MOD:00933. 9448752 PubMed 319#R UniMod Delta:H(2)C(3)O(1) PSI-MS-label MDA adduct +54 UniMod-description DiffAvg 54.05 DiffFormula C 3 H 2 O 1 DiffMono 54.010565 Formula C 9 H 14 N 4 O 2 MassAvg 210.24 MassMono 210.111676 Origin R Source artifact TermSpec none 1 PSI-MOD MOD:01253 malondialdehyde lysine adduct (+54 amu) modification from UniMod Chemical derivative - Malondialdehyde (MDA) adduct 319#K UniMod Delta:H(2)C(3)O(1) PSI-MS-label MDA adduct +54 UniMod-description DiffAvg 54.05 DiffFormula C 3 H 2 O 1 DiffMono 54.010565 Formula C 9 H 14 N 2 O 2 MassAvg 182.22 MassMono 182.105528 Origin K Source artifact TermSpec none MOD:00630 MOD:00912 PSI-MOD MOD:01254 4x(2)H labeled dimethylated L-lysine A protein modification that effectively converts an L-lysine residue to 4x(2)H labeled dimethylated L-lysine. 14670044 PubMed 199#K UniMod PSI-MOD-slim DiMethyl-CHD2 UniMod-description Dimethyl:2H(4) PSI-MS-label mod189 OMSSA-label DiffAvg 32.06 DiffFormula C 2 (2)H 4 DiffMono 32.056407 Formula C 8 H 12 (2)H 4 N 2 O 1 MassAvg 160.15 MassMono 160.151370 Origin K Source artifact TermSpec none MOD:00552 MOD:00912 derives_from MOD:000840 PSI-MOD MOD:01255 S-(2-sulfanylethyl)cysteine (Ser) A protein modification that effectively converts an L-serine residue to S-(2-sulfanylethyl)cysteine. 11507762 PubMed 200#S UniMod EDT UniMod-description Ethanedithiol PSI-MS-label S-(2-mercaptoethyl)cysteine PSI-MOD-alternate DiffAvg 76.18 DiffFormula C 2 H 4 O -1 S 2 DiffMono 75.980528 Formula C 5 H 9 N 1 O 1 S 2 MassAvg 163.25 MassMono 163.012556 Origin S Source artifact TermSpec none MOD:00553 MOD:00916 PSI-MOD MOD:01256 3-methyl-S-(2-sulfanylethyl)cysteine (Thr) A protein modification that effectively converts an L-threonine residue to 3-methyl-S-(2-sulfanylethyl)cysteine. 11507762 PubMed 200#T UniMod beta-methyl-S-(2-mercaptoethyl)cysteine PSI-MOD-alternate EDT UniMod-description Ethanedithiol PSI-MS-label DiffAvg 76.18 DiffFormula C 2 H 4 O -1 S 2 DiffMono 75.980528 Formula C 6 H 11 N 1 O 1 S 2 MassAvg 177.28 MassMono 177.028206 Origin T Source artifact TermSpec none MOD:00553 MOD:00917 PSI-MOD MOD:01257 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate - site K modification from UniMod Chemical derivative - 12716131 PubMed 14997490 PubMed 194#K UniMod 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate UniMod-description AccQTag PSI-MS-label DiffAvg 170.17 DiffFormula C 10 H 6 N 2 O 1 DiffMono 170.048013 Formula C 16 H 18 N 4 O 2 MassAvg 298.35 MassMono 298.142976 Origin K Source artifact TermSpec none MOD:00547 PSI-MOD MOD:01258 N-methylmaleimide - site C modification from UniMod Chemical derivative - 9448752 PubMed 314#C UniMod Nmethylmaleimide PSI-MS-label Nmethylmaleimide UniMod-description DiffAvg 111.10 DiffFormula C 5 H 5 N 1 O 2 DiffMono 111.032028 Formula C 8 H 10 N 2 O 3 S 1 MassAvg 214.24 MassMono 214.041213 Origin C Source artifact TermSpec none MOD:00625 MOD:00905 PSI-MOD MOD:01259 N-methylmaleimide - site K modification from UniMod Chemical derivative - 9448752 PubMed 314#K UniMod Nmethylmaleimide PSI-MS-label Nmethylmaleimide UniMod-description DiffAvg 111.10 DiffFormula C 5 H 5 N 1 O 2 DiffMono 111.032028 Formula C 11 H 17 N 3 O 3 MassAvg 239.27 MassMono 239.126991 Origin K Source artifact TermSpec none MOD:00625 MOD:00912 PSI-MOD MOD:01260 nucleophilic addtion to cytopiloyne - site Y modification from UniMod Chemical derivative - 15549660 PubMed 270#Y UniMod Cytopiloyne PSI-MS-label nucleophilic addtion to cytopiloyne UniMod-description DiffAvg 362.38 DiffFormula C 19 H 22 O 7 DiffMono 362.136553 Formula C 28 H 31 N 1 O 9 MassAvg 525.55 MassMono 525.199882 Origin Y Source artifact TermSpec none MOD:00590 MOD:00919 PSI-MOD MOD:01261 nucleophilic addtion to cytopiloyne - site S modification from UniMod Chemical derivative - 15549660 PubMed 270#C UniMod Cytopiloyne PSI-MS-label nucleophilic addtion to cytopiloyne UniMod-description DiffAvg 362.38 DiffFormula C 19 H 22 O 7 DiffMono 362.136553 Formula C 22 H 27 N 1 O 9 MassAvg 449.46 MassMono 449.168581 Origin S Source artifact TermSpec none MOD:00590 MOD:00916 PSI-MOD MOD:01262 nucleophilic addtion to cytopiloyne - site R modification from UniMod Chemical derivative - 12590383 PubMed 15549660 PubMed 270#R UniMod Cytopiloyne PSI-MS-label nucleophilic addtion to cytopiloyne UniMod-description DiffAvg 362.38 DiffFormula C 19 H 22 O 7 DiffMono 362.136553 Formula C 25 H 34 N 4 O 8 MassAvg 518.57 MassMono 518.237664 Origin R Source artifact TermSpec none MOD:00590 MOD:00902 PSI-MOD MOD:01263 nucleophilic addtion to cytopiloyne - site K modification from UniMod Chemical derivative - 15549660 PubMed 270#K UniMod Cytopiloyne PSI-MS-label nucleophilic addtion to cytopiloyne UniMod-description DiffAvg 362.38 DiffFormula C 19 H 22 O 7 DiffMono 362.136553 Formula C 25 H 34 N 2 O 8 MassAvg 490.55 MassMono 490.231516 Origin K Source artifact TermSpec none MOD:00590 MOD:00912 PSI-MOD MOD:01264 nucleophilic addtion to cytopiloyne - site C modification from UniMod Chemical derivative - 15549660 PubMed 270#C UniMod Cytopiloyne PSI-MS-label nucleophilic addtion to cytopiloyne UniMod-description DiffAvg 362.38 DiffFormula C 19 H 22 O 7 DiffMono 362.136553 Formula C 22 H 27 N 1 O 8 S 1 MassAvg 465.52 MassMono 465.145738 Origin C Source artifact TermSpec none MOD:00590 MOD:00905 PSI-MOD MOD:01265 nucleophilic addtion to cytopiloyne - site P modification from UniMod Chemical derivative - 15549660 PubMed 270#P UniMod Cytopiloyne PSI-MS-label nucleophilic addtion to cytopiloyne UniMod-description DiffAvg 362.38 DiffFormula C 19 H 22 O 7 DiffMono 362.136553 Formula C 24 H 29 N 1 O 8 MassAvg 459.50 MassMono 459.189317 Origin P Source artifact TermSpec none MOD:00590 MOD:00915 PSI-MOD MOD:01266 nucleophilic addition to cytopiloyne+H2O - site C modification from UniMod Chemical derivative - 15549660 PubMed 271#C UniMod Cytopiloyne+water PSI-MS-label nucleophilic addition to cytopiloyne+H2O UniMod-description DiffAvg 380.39 DiffFormula C 19 H 24 O 8 DiffMono 380.147118 Formula C 22 H 29 N 1 O 9 S 1 MassAvg 483.53 MassMono 483.156303 Origin C Source artifact TermSpec none MOD:00591 MOD:00905 PSI-MOD MOD:01267 nucleophilic addition to cytopiloyne+H2O - site K modification from UniMod Chemical derivative - 11746907 PubMed 15549660 PubMed 271#K UniMod Cytopiloyne+water PSI-MS-label nucleophilic addition to cytopiloyne+H2O UniMod-description DiffAvg 380.39 DiffFormula C 19 H 24 O 8 DiffMono 380.147118 Formula C 25 H 36 N 2 O 9 MassAvg 508.57 MassMono 508.242081 Origin K Source artifact TermSpec none MOD:00591 MOD:00912 PSI-MOD MOD:01268 nucleophilic addition to cytopiloyne+H2O - site T modification from UniMod Chemical derivative - 15549660 PubMed 271#T UniMod Cytopiloyne+water PSI-MS-label nucleophilic addition to cytopiloyne+H2O UniMod-description DiffAvg 380.39 DiffFormula C 19 H 24 O 8 DiffMono 380.147118 Formula C 23 H 31 N 1 O 10 MassAvg 481.50 MassMono 481.194796 Origin T Source artifact TermSpec none MOD:00591 MOD:00917 PSI-MOD MOD:01269 nucleophilic addition to cytopiloyne+H2O - site R modification from UniMod Chemical derivative - 15549660 PubMed 271#R UniMod Cytopiloyne+water PSI-MS-label nucleophilic addition to cytopiloyne+H2O UniMod-description DiffAvg 380.39 DiffFormula C 19 H 24 O 8 DiffMono 380.147118 Formula C 25 H 36 N 4 O 9 MassAvg 536.58 MassMono 536.248229 Origin R Source artifact TermSpec none MOD:00591 MOD:00902 PSI-MOD MOD:01270 nucleophilic addition to cytopiloyne+H2O - site S modification from UniMod Chemical derivative - 14670044 PubMed 15549660 PubMed 271#S UniMod Cytopiloyne+water PSI-MS-label nucleophilic addition to cytopiloyne+H2O UniMod-description DiffAvg 380.39 DiffFormula C 19 H 24 O 8 DiffMono 380.147118 Formula C 22 H 29 N 1 O 10 MassAvg 467.47 MassMono 467.179146 Origin S Source artifact TermSpec none MOD:00591 MOD:00916 PSI-MOD MOD:01271 nucleophilic addition to cytopiloyne+H2O - site Y modification from UniMod Chemical derivative - 15549660 PubMed 271#Y UniMod Cytopiloyne+water PSI-MS-label nucleophilic addition to cytopiloyne+H2O UniMod-description DiffAvg 380.39 DiffFormula C 19 H 24 O 8 DiffMono 380.147118 Formula C 28 H 33 N 1 O 10 MassAvg 543.57 MassMono 543.210446 Origin Y Source artifact TermSpec none MOD:00591 MOD:00919 PSI-MOD MOD:01272 iminobiotinylation - site K modification from UniMod Chemical derivative - 9750125 PubMed 89#K UniMod Iminobiotin PSI-MS-label Iminobiotinylation UniMod-description DiffAvg 225.31 DiffFormula C 10 H 15 N 3 O 1 S 1 DiffMono 225.093583 Formula C 16 H 27 N 5 O 2 S 1 MassAvg 353.49 MassMono 353.188546 Origin K Source artifact TermSpec none MOD:00467 MOD:01875 PSI-MOD MOD:01273 O-[4-(2-aminoethyl)benzenesulfonyl] serine A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-serine residue. 15283597 PubMed 8597590 PubMed 276#S UniMod AEBS PSI-MS-label Aminoethylbenzenesulfonylation UniMod-description DiffAvg 183.23 DiffFormula C 8 H 9 N 1 O 2 S 1 DiffMono 183.035400 Formula C 11 H 14 N 2 O 4 S 1 MassAvg 270.30 MassMono 270.067428 Origin S Source artifact TermSpec none MOD:00596 MOD:00916 PSI-MOD MOD:01274 N'-[4-(2-aminoethyl)benzenesulfonyl] derivatized histidine A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-histidine residue. 8597590 PubMed 276#H UniMod AEBS PSI-MS-label Aminoethylbenzenesulfonylation UniMod-description DiffAvg 183.23 DiffFormula C 8 H 9 N 1 O 2 S 1 DiffMono 183.035400 Formula C 14 H 16 N 4 O 3 S 1 MassAvg 320.37 MassMono 320.094311 Origin H Source artifact TermSpec none MOD:00596 MOD:00909 PSI-MOD MOD:01275 N6-[4-(2-aminoethyl)benzenesulfonyl]lysine A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-lysine residue. 8597590 PubMed 276#K UniMod AEBS PSI-MS-label Aminoethylbenzenesulfonylation UniMod-description DiffAvg 183.23 DiffFormula C 8 H 9 N 1 O 2 S 1 DiffMono 183.035400 Formula C 14 H 21 N 3 O 3 S 1 MassAvg 311.40 MassMono 311.130363 Origin K Source artifact TermSpec none MOD:00596 MOD:00912 PSI-MOD MOD:01276 O4'-[4-(2-aminoethyl)benzenesulfonyl]tyrosine A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-tyrosine residue. 10906242 PubMed 8597590 PubMed 276#Y UniMod AEBS PSI-MS-label Aminoethylbenzenesulfonylation UniMod-description DiffAvg 183.23 DiffFormula C 8 H 9 N 1 O 2 S 1 DiffMono 183.035400 Formula C 17 H 18 N 2 O 4 S 1 MassAvg 346.40 MassMono 346.098728 Origin Y Source artifact TermSpec none MOD:00596 MOD:00919 PSI-MOD MOD:01277 crotonaldehyde - site C modification from UniMod Other - 11283024 PubMed 253#C UniMod Crotonaldehyde PSI-MS-label Crotonaldehyde UniMod-description DiffAvg 70.09 DiffFormula C 4 H 6 O 1 DiffMono 70.041865 Formula C 7 H 11 N 1 O 2 S 1 MassAvg 173.23 MassMono 173.051050 Origin C Source artifact TermSpec none MOD:00576 MOD:00905 PSI-MOD MOD:01278 crotonaldehyde - site K modification from UniMod Other - 11283024 PubMed 253#K UniMod Crotonaldehyde PSI-MS-label Crotonaldehyde UniMod-description DiffAvg 70.09 DiffFormula C 4 H 6 O 1 DiffMono 70.041865 Formula C 10 H 18 N 2 O 2 MassAvg 198.27 MassMono 198.136828 Origin K Source artifact TermSpec none MOD:00576 MOD:00912 PSI-MOD MOD:01279 crotonaldehyde - site H modification from UniMod Other - 11283024 PubMed 1443554 PubMed 253#H UniMod Crotonaldehyde PSI-MS-label Crotonaldehyde UniMod-description DiffAvg 70.09 DiffFormula C 4 H 6 O 1 DiffMono 70.041865 Formula C 10 H 13 N 3 O 2 MassAvg 207.23 MassMono 207.100777 Origin H Source artifact TermSpec none MOD:00576 MOD:00909 PSI-MOD MOD:01280 EDT-iodo-PEO-biotin - site T modification from UniMod Chemical derivative - 11857757 PubMed 12175151 PubMed 118#T UniMod EDT-iodo-PEO-biotin UniMod-description EDT-iodoacetyl-PEO-biotin PSI-MS-label DiffAvg 490.70 DiffFormula C 20 H 34 N 4 O 4 S 3 DiffMono 490.174219 Formula C 24 H 41 N 5 O 6 S 3 MassAvg 591.80 MassMono 591.221897 Origin T Source artifact TermSpec none MOD:00490 MOD:00917 PSI-MOD MOD:01281 EDT-iodo-PEO-biotin - site S modification from UniMod Chemical derivative - 16335955 PubMed 118#S UniMod EDT-iodo-PEO-biotin UniMod-description EDT-iodoacetyl-PEO-biotin PSI-MS-label DiffAvg 490.70 DiffFormula C 20 H 34 N 4 O 4 S 3 DiffMono 490.174219 Formula C 23 H 39 N 5 O 6 S 3 MassAvg 577.77 MassMono 577.206247 Origin S Source artifact TermSpec none MOD:00490 MOD:00916 PSI-MOD MOD:01282 acrolein addition +56 - site H modification from UniMod Other - 10825247 PubMed 15541752 PubMed 206#H UniMod Acrolein addition +56 UniMod-description Delta:H(4)C(3)O(1) PSI-MS-label DiffAvg 56.06 DiffFormula C 3 H 4 O 1 DiffMono 56.026215 Formula C 9 H 11 N 3 O 2 MassAvg 193.21 MassMono 193.085127 Origin H Source artifact TermSpec none MOD:00557 MOD:00909 PSI-MOD MOD:01283 acrolein addition +56 - site K modification from UniMod Other - 10825247 PubMed 15541752 PubMed 206#K UniMod Acrolein addition +56 UniMod-description Delta:H(4)C(3)O(1) PSI-MS-label DiffAvg 56.06 DiffFormula C 3 H 4 O 1 DiffMono 56.026215 Formula C 9 H 16 N 2 O 2 MassAvg 184.24 MassMono 184.121178 Origin K Source artifact TermSpec none MOD:00557 MOD:00912 PSI-MOD MOD:01284 acrolein addition +56 - site C modification from UniMod Other - 10825247 PubMed 15541752 PubMed 9254591 PubMed 206#C UniMod Acrolein addition +56 UniMod-description Delta:H(4)C(3)O(1) PSI-MS-label DiffAvg 56.06 DiffFormula C 3 H 4 O 1 DiffMono 56.026215 Formula C 6 H 9 N 1 O 2 S 1 MassAvg 159.20 MassMono 159.035400 Origin C Source artifact TermSpec none MOD:00557 MOD:00905 PSI-MOD MOD:01285 6x(13)C,1x(15)N labeled L-leucine A protein modification that effectively converts an L-leucine residue to 6x(13)C,1x(15)N isotope labeled L-leucine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 695#L UniMod 13C(6) 15N(1) Silac label UniMod-description Label:13C(6)15N(1) PSI-MS-label DiffAvg 7.02 DiffFormula (12)C -6 (13)C 6 (14)N -1 (15)N 1 DiffMono 7.017164 Formula (13)C 6 H 11 (15)N 1 O 1 MassAvg 120.10 MassMono 120.101228 Origin L Source artifact TermSpec none MOD:00911 MOD:01370 PSI-MOD MOD:01286 6x(13)C,1x(15)N labeled L-isoleucine A protein modification that effectively converts an L-isoleucine residue to 6x(13)C,1x(15)N isotope labeled L-isoleucine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 695#I UniMod 13C(6) 15N(1) Silac label UniMod-description Label:13C(6)15N(1) PSI-MS-label DiffAvg 7.02 DiffFormula (12)C -6 (13)C 6 (14)N -1 (15)N 1 DiffMono 7.017164 Formula (13)C 6 H 11 (15)N 1 O 1 MassAvg 120.10 MassMono 120.101228 Origin I Source artifact TermSpec none MOD:00910 MOD:01370 PSI-MOD MOD:01287 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form - site K modification from UniMod Isotopic label - 11857757 PubMed 15602776 PubMed 364#K UniMod Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form UniMod-description ICPL:13C(6) PSI-MS-label DiffAvg 111.04 DiffFormula (13)C 6 H 3 N 1 O 1 DiffMono 111.041593 Formula C 6 (13)C 6 H 15 N 3 O 2 MassAvg 239.14 MassMono 239.136556 Origin K Source artifact TermSpec none MOD:00789 MOD:00912 PSI-MOD MOD:01288 acetaldehyde +28 - site H modification from UniMod Other - 255#H UniMod Acetaldehyde +28 UniMod-description Delta:H(4)C(2) PSI-MS-label DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula C 8 H 11 N 3 O 1 MassAvg 165.20 MassMono 165.090212 Origin H Source artifact TermSpec none MOD:00578 MOD:00909 PSI-MOD MOD:01289 acetaldehyde +28 - site K modification from UniMod Other - 255#K UniMod Acetaldehyde +28 UniMod-description Delta:H(4)C(2) PSI-MS-label DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula C 8 H 16 N 2 O 1 MassAvg 156.23 MassMono 156.126263 Origin K Source artifact TermSpec none MOD:00578 MOD:00912 PSI-MOD MOD:01290 dihydroxylated residue - site F OBSOLETE because redundant and identical to MOD:00465. Remap to MOD:00465. 11857757 PubMed 12175151 PubMed 12686488 PubMed 9252331 PubMed 425 UniMod dihydroxy UniMod-description Dioxidation PSI-MS-label DiffAvg 32.00 DiffFormula O 2 DiffMono 31.989829 Formula C 9 H 9 N 1 O 3 MassAvg 179.17 MassMono 179.058243 Origin F Source artifact TermSpec none 1 PSI-MOD MOD:01291 dihydroxylated residue - site W OBSOLETE because redundant and identical to MOD:00464. Remap to MOD:00464. 12643539 PubMed 12686488 PubMed 6273432 PubMed 9252331 PubMed 425 UniMod dihydroxy UniMod-description Dioxidation PSI-MS-label DiffAvg 32.00 DiffFormula O 2 DiffMono 31.989829 Formula C 11 H 10 N 2 O 3 MassAvg 218.21 MassMono 218.069142 Origin W Source artifact TermSpec none 1 PSI-MOD MOD:01292 dimethylation of proline residue OBSOLETE because redundant and identical to MOD:00075. Map to MOD:00075. 529 UniMod Delta:H(5)C(2) PSI-MS-label Dimethylation of proline residue UniMod-description DiffAvg 29.06 DiffFormula C 2 H 5 DiffMono 29.039125 Formula none MassAvg none MassMono none Origin P Source natural TermSpec none 1 PSI-MOD MOD:01293 1x(18)O labeled deamidated L-asparagine A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O. 8382902 PubMed 366#N UniMod PSI-MOD-slim Deamidated:18O(1) PSI-MS-label Deamidation in presence of O18 UniMod-description oxy18 OMSSA-label DiffAvg 2.99 DiffFormula H -1 N -1 (18)O 1 DiffMono 2.988262 Formula C 4 H 5 N 1 (16)O 2 (18)O 1 MassAvg 117.03 MassMono 117.031189 Origin N Source artifact TermSpec none MOD:00852 derives_from MOD:006840 PSI-MOD MOD:01294 deamidation in presence of O18 -site Q OBSOLETE identical and redundant with MOD:00791. Remap to MOD:00791. 8382902 PubMed Deamidated:18O(1) PSI-MS-label Deamidation in presence of O18 UniMod-description DiffAvg 2.99 DiffFormula H -1 N -1 (18)O 1 DiffMono 2.988262 Formula none MassAvg none MassMono none Origin Q Source artifact TermSpec none 1 PSI-MOD MOD:01295 monosodium L-aspartate A protein modification that effectively converts an L-aspartic acid residue to monosodium L-aspartate. 12216740 PubMed 30#D UniMod PSI-MOD-slim Cation:Na PSI-MS-label Na1Asp PSI-MOD-label Sodium adduct UniMod-description DiffAvg 21.98 DiffFormula H -1 Na 1 DiffMono 21.981944 Formula C 4 H 4 N 1 Na 1 O 3 MassAvg 137.07 MassMono 137.008887 Origin D Source artifact TermSpec none MOD:00423 MOD:00904 PSI-MOD MOD:01296 monosodium L-glutamate A protein modification that effectively converts an L-glutamic acid residue to monosodium L-glutamate. 12216740 PubMed 30#E UniMod PSI-MOD-slim Cation:Na PSI-MS-label MSG PSI-MOD-alternate Na1Glu PSI-MOD-label Sodium adduct UniMod-description DiffAvg 21.98 DiffFormula H -1 Na 1 DiffMono 21.981944 Formula C 5 H 6 N 1 Na 1 O 3 MassAvg 151.10 MassMono 151.024537 Origin E Source artifact TermSpec none MOD:00423 MOD:00906 PSI-MOD MOD:01297 5x(13)C labeled L-proline A protein modification that effectively converts an L-proline residue to 5x(13)C labeled L-proline. 12716131 PubMed 772#P UniMod In PubMed:12716131, fully (13)C labeled proline apparently resulted from the catabolic conversion of (13)C labeled L-arginine during SILAC. 13C(5) Silac label UniMod-description Label:13C(5) PSI-MS-label DiffAvg 5.02 DiffFormula (12)C -5 (13)C 5 DiffMono 5.016774 Formula (13)C 5 H 7 N 1 O 1 MassAvg 102.07 MassMono 102.069538 Origin P Source artifact TermSpec none MOD:00915 MOD:01832 PSI-MOD MOD:01298 reduced cysteine 4-hydroxynonenal adduct A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. 11910026 PubMed 15133838 PubMed 335#C UniMod 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. HNE+Delta:H(2) PSI-MS-label reduced 4-Hydroxynonenal UniMod-description DiffAvg 158.24 DiffFormula C 9 H 18 O 2 DiffMono 158.130680 Formula C 12 H 23 N 1 O 3 S 1 MassAvg 261.38 MassMono 261.139865 Origin C Source artifact TermSpec none MOD:00642 MOD:00905 derives_from MOD:012370 PSI-MOD MOD:01299 reduced lysine 4-hydroxynonenal adduct A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. 11910026 PubMed 12148805 PubMed 15133838 PubMed 335#K UniMod 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. HNE+Delta:H(2) PSI-MS-label reduced 4-Hydroxynonenal UniMod-description DiffAvg 158.24 DiffFormula C 9 H 18 O 2 DiffMono 158.130680 Formula C 15 H 30 N 2 O 3 MassAvg 286.42 MassMono 286.225643 Origin K Source artifact TermSpec none MOD:00642 MOD:00912 derives_from MOD:012380 PSI-MOD MOD:01300 reduced histidine 4-hydroxynonenal adduct A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. 11910026 PubMed 12148805 PubMed 15133838 PubMed 335#H UniMod 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. HNE+Delta:H(2) PSI-MS-label reduced 4-Hydroxynonenal UniMod-description DiffAvg 158.24 DiffFormula C 9 H 18 O 2 DiffMono 158.130680 Formula C 15 H 25 N 3 O 3 MassAvg 295.38 MassMono 295.189592 Origin H Source artifact TermSpec none MOD:00642 MOD:00909 derives_from MOD:012390 PSI-MOD MOD:01301 methylamine Michael addition derivatized threonine A protein modification that effectively converts an L-threonine residue to 2-amino-3-(methylamino)butanoic acid. 11743741 PubMed 337#T UniMod In PubMed:11743741 phosphothreonine is converted to dehydrobutyrine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)butanoic acid. Methylamine PSI-MS-label Michael addition with methylamine UniMod-description DiffAvg 13.04 DiffFormula C 1 H 3 N 1 O -1 DiffMono 13.031634 Formula C 5 H 10 N 2 O 1 MassAvg 114.15 MassMono 114.079313 Origin T Source artifact TermSpec none MOD:00643 MOD:00917 PSI-MOD MOD:01302 methylamine Michael addition derivatized serine A protein modification that effectively converts an L-serine residue to 2-amino-3-(methylamino)propanoic acid. 11743741 PubMed 337#S UniMod In PubMed:11743741 phosphoserine is converted to dehydroalanine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)propanoic acid. Methylamine PSI-MS-label Michael addition with methylamine UniMod-description DiffAvg 13.04 DiffFormula C 1 H 3 N 1 O -1 DiffMono 13.031634 Formula C 4 H 8 N 2 O 1 MassAvg 100.12 MassMono 100.063663 Origin S Source artifact TermSpec none MOD:00643 MOD:00916 PSI-MOD MOD:01303 N4-hexosaminylated asparagine A protein modification that effectively converts an L-asparagine residue to an N4-hexosaminyl-L-asparagine. 11467524 PubMed 454#N UniMod The natural modifications are N4-(N-acetylamino)galactosyl-L-asparagine (MOD:00832) or N4-(N-acetylamino)glucosyl-L-asparagine (MOD:00831) [JSG]. HexN PSI-MS-label Hexosamine UniMod-description DiffAvg 161.16 DiffFormula C 6 H 11 N 1 O 4 DiffMono 161.068808 Formula C 10 H 17 N 3 O 6 MassAvg 275.26 MassMono 275.111735 Origin N Source artifact TermSpec none MOD:00160 MOD:00876 PSI-MOD MOD:01304 N6-hexosaminylated lysine A protein modification that effectively converts an L-lysine residue to an N4-hexosaminyl-L-lysine, as a synthetic peptide protectting group. 454#K UniMod HexN PSI-MS-label Hexosamine UniMod-description DiffAvg 161.16 DiffFormula C 6 H 11 N 1 O 4 DiffMono 161.068808 Formula C 12 H 23 N 3 O 5 MassAvg 289.33 MassMono 289.163771 Origin K Source artifact TermSpec none MOD:00876 MOD:00912 PSI-MOD MOD:01305 N1'-hexosaminylated tryptophan A protein modification that effectively converts an L-tryptophan residue to N1'-hexosaminyl-L-tryptophan. 454#W UniMod The natural modification is N1'-mannosyl-L-tryptophan (MOD:00165) [JSG]. HexN PSI-MS-label Hexosamine UniMod-description DiffAvg 161.16 DiffFormula C 6 H 11 N 1 O 4 DiffMono 161.068808 Formula C 17 H 21 N 3 O 5 MassAvg 347.37 MassMono 347.148121 Origin W Source artifact TermSpec none MOD:00876 MOD:00918 PSI-MOD MOD:01306 O-hexosaminylated threonine A protein modification that effectively converts an L-threonine residue to O-hexosaminyl-L-threonine. 454#T UniMod The natural modifications are O-(N-acetylaminogalactosyl)-L-threonine (MOD:00164) or O-(N-acetylaminoglucosyl)-L-threonine (MOD:00806) [JSG]. HexN PSI-MS-label Hexosamine UniMod-description DiffAvg 161.16 DiffFormula C 6 H 11 N 1 O 4 DiffMono 161.068808 Formula C 10 H 18 N 2 O 6 MassAvg 262.26 MassMono 262.116486 Origin T Source natural TermSpec none MOD:00005 MOD:00876 PSI-MOD MOD:01307 thiophosphate labeled with biotin-HPDP -site S modification from UniMod Chemical derivative - 332#S UniMod Thiophos-S-S-biotin PSI-MS-label thiophosphate labeled with biotin-HPDP UniMod-description DiffAvg 525.66 DiffFormula C 19 H 34 N 4 O 5 P 1 S 3 DiffMono 525.142895 Formula C 22 H 39 N 5 O 7 P 1 S 3 MassAvg 612.74 MassMono 612.174923 Origin S Source artifact TermSpec none MOD:00639 MOD:00916 PSI-MOD MOD:01308 thiophosphate labeled with biotin-HPDP -site T modification from UniMod Chemical derivative - 332#T UniMod Thiophos-S-S-biotin PSI-MS-label thiophosphate labeled with biotin-HPDP UniMod-description DiffAvg 525.66 DiffFormula C 19 H 34 N 4 O 5 P 1 S 3 DiffMono 525.142895 Formula C 23 H 41 N 5 O 7 P 1 S 3 MassAvg 626.76 MassMono 626.190573 Origin T Source artifact TermSpec none MOD:00639 MOD:00917 PSI-MOD MOD:01309 thiophosphate labeled with biotin-HPDP - site Y modification from UniMod Chemical derivative - 332#Y UniMod Thiophos-S-S-biotin PSI-MS-label thiophosphate labeled with biotin-HPDP UniMod-description DiffAvg 525.66 DiffFormula C 19 H 34 N 4 O 5 P 1 S 3 DiffMono 525.142895 Formula C 28 H 43 N 5 O 7 P 1 S 3 MassAvg 688.83 MassMono 688.206223 Origin Y Source artifact TermSpec none MOD:00639 MOD:00919 PSI-MOD MOD:01310 quaternary amine labeling reagent light form N6-L-lysine A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent light form group. 11857757 PubMed 60#K UniMod GIST-Quat PSI-MS-label Quaternary amine labeling reagent light form (N-term & K) UniMod-description DiffAvg 59.07 DiffFormula C 3 (1)H 9 N 1 DiffMono 59.073499 Formula C 9 (1)H 21 N 3 O 1 MassAvg 187.17 MassMono 187.168462 Origin K Source artifact TermSpec none MOD:00912 MOD:01426 PSI-MOD MOD:01311 quaternary amine labeling reagent heavy form (+3amu) N6-L-lysine A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+3amu) form group. 11698400 PubMed 11857757 PubMed 11914093 PubMed 61#K UniMod GIST-Quat:2H(3) PSI-MS-label Quaternary amine labeling reagent heavy (+3amu) form, N-term & K UniMod-description DiffAvg 62.09 DiffFormula C 3 (1)H 6 (2)H 3 N 1 DiffMono 62.092330 Formula C 9 (1)H 18 (2)H 3 N 3 O 1 MassAvg 190.19 MassMono 190.187293 Origin K Source artifact TermSpec none MOD:00912 MOD:01426 PSI-MOD MOD:01312 quaternary amine labeling reagent heavy form (+6amu) N6-L-lysine A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+6amu) form group. 11857757 PubMed 62#K UniMod Apparently incorrect parent [JSG]. GIST-Quat:2H(6) PSI-MS-label Quaternary amine labeling reagent heavy form (+6amu), N-term & K UniMod-description DiffAvg 65.11 DiffFormula C 3 (1)H 3 (2)H 6 N 1 DiffMono 65.111160 Formula C 9 (1)H 15 (2)H 6 N 3 O 1 MassAvg 193.21 MassMono 193.206123 Origin K Source artifact TermSpec none MOD:00912 MOD:01426 PSI-MOD MOD:01313 quaternary amine labeling reagent heavy form (+9amu) N6-L-lysine A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+9amu) form group. 11857757 PubMed 63#K UniMod GIST-Quat:2H(9) PSI-MS-label Quaternary amine labeling reagent heavy form (+9amu), N-term & K UniMod-description DiffAvg 68.13 DiffFormula C 3 (2)H 9 N 1 DiffMono 68.129990 Formula C 9 (1)H 12 (2)H 9 N 3 O 1 MassAvg 196.22 MassMono 196.224953 Origin K Source artifact TermSpec none MOD:00912 MOD:01426 PSI-MOD MOD:01314 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine A protein modification that effectively converts an L-lysine residue to 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine. 11857757 PubMed 12175151 PubMed 12716131 PubMed 64#K UniMod Succinic anhydride labeling reagent light form (K) UniMod-description Succinyl PSI-MS-label DiffAvg 100.02 DiffFormula (12)C 4 (1)H 4 O 3 DiffMono 100.016044 Formula (12)C 10 H 16 N 2 O 4 MassAvg 228.11 MassMono 228.111007 Origin K Source artifact TermSpec none MOD:01426 MOD:01819 PSI-MOD MOD:01315 4x(2)H labeled N6-succinyl-L-lysine A protein modification that effectively converts an L-lysine residue to 4x(2)H-labeled N6-succinyl-L-lysine. 11344537 PubMed 11857757 PubMed 12175151 PubMed 15189151 PubMed 65#K UniMod Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term & K UniMod-description Succinyl:2H(4) PSI-MS-label DiffAvg 104.04 DiffFormula C 4 (2)H 4 O 3 DiffMono 104.041151 Formula C 10 (1)H 12 (2)H 4 N 2 O 4 MassAvg 232.14 MassMono 232.136114 Origin K Source artifact TermSpec none MOD:01819 PSI-MOD MOD:01316 4x(13)C labeled N6-succinyl-L-lysine A protein modification that effectively converts an L-lysine residue to 4x(13)C labeled N6-succinyl-L-lysine. 11344537 PubMed 11857757 PubMed 12175151 PubMed 15189151 PubMed 66#K UniMod Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), K UniMod-description Succinyl:13C(4) PSI-MS-label DiffAvg 104.03 DiffFormula (13)C 4 H 4 O 3 DiffMono 104.029463 Formula (12)C 6 (13)C 4 H 16 N 2 O 4 MassAvg 232.12 MassMono 232.124426 Origin K Source artifact TermSpec none MOD:01819 PSI-MOD MOD:01317 phosphorylation to amine thiol - site T modification from UniMod Chemical derivative - 12216740 PubMed 178#T UniMod DAET PSI-MS-label phosphorylation to amine thiol UniMod-description DiffAvg 87.18 DiffFormula C 4 H 9 N 1 O -1 S 1 DiffMono 87.050656 Formula C 8 H 16 N 2 O 1 S 1 MassAvg 188.29 MassMono 188.098334 Origin T Source artifact TermSpec none MOD:00535 MOD:00917 PSI-MOD MOD:01318 phosphorylation to amine thiol - site S modification from UniMod Chemical derivative - 11510821 PubMed 12216740 PubMed 12422359 PubMed 178#S UniMod DAET PSI-MS-label phosphorylation to amine thiol UniMod-description DiffAvg 87.18 DiffFormula C 4 H 9 N 1 O -1 S 1 DiffMono 87.050656 Formula C 7 H 14 N 2 O 1 S 1 MassAvg 174.26 MassMono 174.082684 Origin S Source artifact TermSpec none MOD:00535 MOD:00916 PSI-MOD MOD:01319 Michael addition of BHT quinone methide to histidine modification from UniMod Other 11510821 PubMed 12422359 PubMed 9448752 PubMed 176#H UniMod Secondary adduct, much less common than cysteine. [UniMod] BHT PSI-MS-label Michael addition of BHT quinone methide to Cysteine and Lysine UniMod-description DiffAvg 218.34 DiffFormula C 15 H 22 O 1 DiffMono 218.167065 Formula C 21 H 29 N 3 O 2 MassAvg 355.48 MassMono 355.225977 Origin H Source artifact TermSpec none MOD:00534 MOD:00909 PSI-MOD MOD:01320 Michael addition of BHT quinone methide to lysine modification from UniMod Other 16078144 PubMed 9448752 PubMed 176#K UniMod Secondary adduct, much less common than cysteine. [UniMod] BHT PSI-MS-label Michael addition of BHT quinone methide to Cysteine and Lysine UniMod-description DiffAvg 218.34 DiffFormula C 15 H 22 O 1 DiffMono 218.167065 Formula C 21 H 34 N 2 O 2 MassAvg 346.51 MassMono 346.262028 Origin K Source artifact TermSpec none MOD:00534 MOD:00912 PSI-MOD MOD:01321 Michael addition of BHT quinone methide to cysteine modification from UniMod Other 11510821 PubMed 12422359 PubMed 9448752 PubMed 176#C UniMod Primary adduct formed. [UniMod] BHT PSI-MS-label Michael addition of BHT quinone methide to Cysteine and Lysine UniMod-description DiffAvg 218.34 DiffFormula C 15 H 22 O 1 DiffMono 218.167065 Formula C 18 H 27 N 1 O 2 S 1 MassAvg 321.48 MassMono 321.176250 Origin C Source artifact TermSpec none MOD:00534 MOD:00905 PSI-MOD MOD:01322 propionaldehyde +40 - site K modification from UniMod Other - 15549660 PubMed 256#K UniMod Delta:H(4)C(3) PSI-MS-label Propionaldehyde +40 UniMod-description DiffAvg 40.06 DiffFormula C 3 H 4 DiffMono 40.031300 Formula C 9 H 16 N 2 O 1 MassAvg 168.24 MassMono 168.126263 Origin K Source artifact TermSpec none MOD:00579 MOD:00912 PSI-MOD MOD:01323 propionaldehyde +40 - site H modification from UniMod Other - 256#H UniMod Delta:H(4)C(3) PSI-MS-label Propionaldehyde +40 UniMod-description DiffAvg 40.06 DiffFormula C 3 H 4 DiffMono 40.031300 Formula C 9 H 11 N 3 O 1 MassAvg 177.21 MassMono 177.090212 Origin H Source artifact TermSpec none MOD:00579 MOD:00909 PSI-MOD MOD:01324 acetaldehyde +26 - site H modification from UniMod Other - 7744761 PubMed 254#H UniMod Acetaldehyde +26 UniMod-description Delta:H(2)C(2) PSI-MS-label DiffAvg 26.04 DiffFormula C 2 H 2 DiffMono 26.015650 Formula C 8 H 9 N 3 O 1 MassAvg 163.18 MassMono 163.074562 Origin H Source artifact TermSpec none MOD:00577 MOD:00909 PSI-MOD MOD:01325 acetaldehyde +26 - site K modification from UniMod Other - 7744761 PubMed 254#K UniMod Acetaldehyde +26 UniMod-description Delta:H(2)C(2) PSI-MS-label DiffAvg 26.04 DiffFormula C 2 H 2 DiffMono 26.015650 Formula C 8 H 14 N 2 O 1 MassAvg 154.21 MassMono 154.110613 Origin K Source artifact TermSpec none MOD:00577 MOD:00912 PSI-MOD MOD:01326 9x(13)C labeled L-tyrosine A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-tyrosine. 11510821 PubMed 12422359 PubMed 12716131 PubMed 184#Y UniMod 13C(9) Silac label UniMod-description Label:13C(9) PSI-MS-label DiffAvg 9.03 DiffFormula (12)C -9 (13)C 9 DiffMono 9.030194 Formula (13)C 9 H 9 N 1 O 2 MassAvg 172.09 MassMono 172.093522 Origin Y Source artifact TermSpec none MOD:00540 MOD:00919 PSI-MOD MOD:01327 9x(13)C labeled L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to 9x(13)C labeled L-phenylalanine. 12716131 PubMed 184#F UniMod 13C(9) Silac label UniMod-description Label:13C(9) PSI-MS-label DiffAvg 9.03 DiffFormula (12)C -9 (13)C 9 DiffMono 9.030194 Formula (13)C 9 H 9 N 1 O 1 MassAvg 156.10 MassMono 156.098607 Origin F Source artifact TermSpec none MOD:00540 MOD:00914 PSI-MOD MOD:01328 iodoacetic acid - site W modification from UniMod Chemical derivative - hydroxylethanone 17525468 PubMed 6#W UniMod There is no citation for this UniMod entry. Iodoacetic acid derivatization of tryptophan is not mentioned in the citation [JSG]. Carboxymethyl PSI-MS-label Iodoacetic acid derivative UniMod-description DiffAvg 58.04 DiffFormula C 2 H 2 O 2 DiffMono 58.005479 Formula C 13 H 12 N 2 O 3 MassAvg 244.25 MassMono 244.084792 Origin W Source artifact TermSpec none MOD:00399 MOD:00918 PSI-MOD MOD:01329 iodoacetic acid - site C OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061 197 DeltaMass Modification from UniMod Chemical derivative, UniMod:6 site C Carboxymethyl PSI-MS-label Iodoacetic acid derivative UniMod-description DiffAvg 58.04 DiffFormula C 2 H 2 O 2 DiffMono 58.005479 Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none 1 PSI-MOD MOD:01330 iodoacetic acid -site K OBSOLETE because identical with MOD:01094. Remap to MOD:01094 18688235 PubMed a modification from UniMod:6 Carboxymethyl PSI-MS-label Iodoacetic acid derivative UniMod-description DiffAvg 58.04 DiffFormula C 2 H 2 O 2 DiffMono 58.005479 Formula none MassAvg none MassMono none Origin K Source artifact TermSpec none 1 PSI-MOD MOD:01331 6x(13)C labeled L-arginine A protein modification that effectively converts an L-arginine residue to 6x(13)C labeled L-arginine. 12716131 PubMed 188#R UniMod PSI-MOD-slim 13C(6) Silac label UniMod-description arg-13c6 OMSSA-label Label:13C(6) PSI-MS-label DiffAvg 6.02 DiffFormula (12)C -6 (13)C 6 DiffMono 6.020129 Formula (13)C 6 H 12 N 4 O 1 MassAvg 162.12 MassMono 162.121240 Origin R Source artifact TermSpec none MOD:00544 PSI-MOD MOD:01332 6x(13)C labeled L-leucine A protein modification that effectively converts an L-leucine residue to 6x(13)C labeled L-leucine. 12716131 PubMed 188#L UniMod PSI-MOD-slim 13C(6) Silac label UniMod-description Label:13C(6) PSI-MS-label DiffAvg 6.02 DiffFormula (12)C -6 (13)C 6 DiffMono 6.020129 Formula (13)C 6 H 11 N 1 O 1 MassAvg 119.10 MassMono 119.104193 Origin L Source artifact TermSpec none MOD:00544 PSI-MOD MOD:01333 6x(13)C labeled L-isoleucine A protein modification that effectively converts an L-isoleucine residue to 6x(13)C labeled L-isoleucine. 12716131 PubMed 12766232 PubMed 188#I UniMod PSI-MOD-slim 13C(6) Silac label UniMod-description Label:13C(6) PSI-MS-label DiffAvg 6.02 DiffFormula (12)C -6 (13)C 6 DiffMono 6.020129 Formula (13)C 6 H 11 N 1 O 1 MassAvg 119.10 MassMono 119.104193 Origin I Source artifact TermSpec none MOD:00544 PSI-MOD MOD:01334 6x(13)C labeled L-lysine A protein modification that effectively converts an L-lysine residue to 6x(13)C labeled L-lysine. 11857757 PubMed 11999733 PubMed 12175151 PubMed 12716131 PubMed 188#K UniMod PSI-MOD-slim 13C(6) Silac label UniMod-description Label:13C(6) PSI-MS-label lys-13c6 OMSSA-label DiffAvg 6.02 DiffFormula (12)C -6 (13)C 6 DiffMono 6.020129 Formula (13)C 6 H 12 N 2 O 1 MassAvg 134.12 MassMono 134.115092 Origin K Source artifact TermSpec none MOD:00544 PSI-MOD MOD:01335 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized lysine modification from UniMod Chemical derivative - 11467524 PubMed 16526082 PubMed 464#K UniMod 4-sulfophenyl isothiocyanate (Heavy C13) UniMod-description SPITC:13C(6) PSI-MS-label DiffAvg 220.99 DiffFormula (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 DiffMono 220.991214 Formula (12)C 7 (13)C 6 H 17 N 3 O 4 S 2 MassAvg 349.09 MassMono 349.086177 Origin K Source artifact TermSpec none MOD:00880 MOD:00912 PSI-MOD MOD:01336 deamidation followed by a methylation -site Q OBSOLETE - identical and redundant with MOD:00657. Remap to MOD:00657. 18688235 PubMed Modification from UniMod Post-translational - UniMod:528. Deamidation followed by a methylation UniMod-description Methyl+Deamidated PSI-MS-label DiffAvg 15.01 DiffFormula C 1 H 1 N -1 O 1 DiffMono 14.999666 Formula none MassAvg none MassMono none Origin Q Source natural TermSpec none 1 PSI-MOD MOD:01337 deamidated 4-methyl esterified asparagine A protein modification that effectively converts an L-asparagine residue to L-aspartate 4-methyl ester. 528#N UniMod The deamidation and methylation of L-asparagine has not been reported as a natural modification. It is extremely unlikely that eukaryotes produce this modification, because a natural process that would form L-aspartic acid 4-methyl ester from either L-aspartic acid or L-asparagine would interfere with the D-aspartyl peptide repair mechanism [JSG]. Deamidation followed by a methylation UniMod-description Methyl+Deamidated PSI-MS-label DiffAvg 15.01 DiffFormula C 1 H 1 N -1 O 1 DiffMono 14.999666 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin N Source artifact TermSpec none MOD:01181 MOD:01369 PSI-MOD MOD:01338 N6-ethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-ethyl-L-lysine. 9629898 PubMed 280#K UniMod The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. Ethyl PSI-MS-label Ethylation UniMod-description DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula C 8 H 16 N 2 O 1 MassAvg 156.23 MassMono 156.126263 Origin K Source hypothetical TermSpec none MOD:00912 MOD:01339 PSI-MOD MOD:01339 ethylated residue A protein modification that effectively replaces a hydrogen atom with an ethyl group. 9629898 PubMed 280 UniMod From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. Ethyl PSI-MS-label Ethylation UniMod-description EtRes PSI-MOD-label DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00001 PSI-MOD MOD:01340 ESP-Tag heavy d10 - site K modification from UniMod Isotopic label - 11078590 PubMed 11085420 PubMed 11821862 PubMed 91#K UniMod ESP-Tag heavy d10 UniMod-description ESP:2H(10) PSI-MS-label DiffAvg 348.24 DiffFormula C 16 (1)H 16 (2)H 10 N 4 O 2 S 1 DiffMono 348.240415 Formula C 22 (1)H 28 (2)H 10 N 6 O 3 S 1 MassAvg 476.34 MassMono 476.335378 Origin K Source artifact TermSpec none MOD:00469 MOD:00912 PSI-MOD MOD:01341 ESP-Tag light d0 - site K modification from UniMod Isotopic label - 90#K UniMod ESP PSI-MS-label ESP-Tag light d0 UniMod-description DiffAvg 338.47 DiffFormula C 16 H 26 N 4 O 2 S 1 DiffMono 338.177647 Formula C 22 H 38 N 6 O 3 S 1 MassAvg 466.64 MassMono 466.272610 Origin K Source artifact TermSpec none MOD:00468 MOD:00912 PSI-MOD MOD:01342 selenium substitution for sulfur - site M OBSOLETE because redundant and identical to MOD:00530. Remap to MOD:00530. 12148805 PubMed 162 UniMod Delta:S(-1)Se(1) PSI-MS-label Selenium replaces sulphur UniMod-description DiffAvg 46.91 DiffFormula S -1 Se 1 DiffMono 47.944450 Formula C 5 H 9 N 1 O 1 S 0 Se 1 MassAvg 178.10 MassMono 178.984935 Origin M Source artifact TermSpec none 1 PSI-MOD MOD:01343 selenium substitution for sulfur - site C OBSOLETE because redundant and identical to MOD:00686. Remap to MOD:00686. 12148805 PubMed 162 UniMod Delta:S(-1)Se(1) PSI-MS-label Selenium replaces sulphur UniMod-description DiffAvg 46.91 DiffFormula S -1 Se 1 DiffMono 47.944450 Formula C 3 H 5 N 1 O 1 S 0 Se 1 MassAvg 150.05 MassMono 150.953635 Origin C Source artifact TermSpec none 1 PSI-MOD MOD:01344 dehydrogenated residue - site S OBSOLETE because redundant and identical with MOD:00835. Remap to MOD:00835. 9252331 PubMed 9276974 PubMed 401 UniMod 2-amino-3-oxo-butanoic_acid UniMod-description Didehydro PSI-MS-label DiffAvg -2.02 DiffFormula H -2 DiffMono -2.015650 Formula none MassAvg none MassMono none Origin S Source natural TermSpec none 1 PSI-MOD MOD:01345 2-amino-3-oxobutanoic acid A protein modification that effectively converts an L-threonine residue to 2-amino-3-oxobutanoic acid. 12716131 PubMed 9252331 PubMed 401#T UniMod There is no citation for this modification in the UniMod entry. Although mentioned in PubMed:9252331, there is no citation for it there [JSG]. 2-amino-3-ketobutyric acid PSI-MOD-alternate 2-amino-3-oxo-butanoic_acid UniMod-description 3-ketobutyrine PSI-MOD-alternate Didehydro PSI-MS-label twoamino3oxobutanoicacid OMSSA-label DiffAvg -2.02 DiffFormula H -2 DiffMono -2.015650 Formula C 4 H 5 N 1 O 2 MassAvg 99.09 MassMono 99.032028 Origin T Source artifact TermSpec none MOD:00917 MOD:01888 PSI-MOD MOD:01346 N4-hexosylated asparagine A protein modification that effectively converts an L-asparagine residue to an N4-hexosyl-L-asparagine. 11112526 PubMed 11567090 PubMed 15279557 PubMed 6540775 PubMed 41#N UniMod Hex PSI-MS-label Hexose UniMod-description DiffAvg 162.14 DiffFormula C 6 H 10 O 5 DiffMono 162.052823 Formula C 10 H 16 N 2 O 7 MassAvg 276.25 MassMono 276.095751 Origin N Source natural TermSpec none MOD:00160 MOD:00434 PSI-MOD MOD:01347 hexose glycated L-lysine A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and an L-lysine residue to form a Schiff-base or an Amadori ketosamine lysine adduct. 0 DeltaMass 15279557 PubMed 41#K UniMod Hex PSI-MS-label Hexose UniMod-description DiffAvg 162.14 DiffFormula C 6 H 10 O 5 DiffMono 162.052823 Formula C 12 H 22 N 2 O 6 MassAvg 290.32 MassMono 290.147786 Origin K Source natural TermSpec none MOD:00767 MOD:00912 PSI-MOD MOD:01348 O-hexosylated threonine A protein modification that effectively converts an L-threonine residue to an O-hexosyl-L-threonine. 15279557 PubMed 8597590 PubMed 41#T UniMod Hex PSI-MS-label Hexose UniMod-description DiffAvg 162.14 DiffFormula C 6 H 10 O 5 DiffMono 162.052823 Formula C 10 H 17 N 1 O 7 MassAvg 263.25 MassMono 263.100502 Origin T Source natural TermSpec none MOD:00005 MOD:00434 PSI-MOD MOD:01349 hydrolyzed N-ethylmaleimide cysteine adduct modification from UniMod Chemical derivative - 320#C UniMod Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(S-cysteinyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. Nethylmaleimide+water PSI-MS-label Nethylmaleimidehydrolysis UniMod-description DiffAvg 143.14 DiffFormula C 6 H 9 N 1 O 3 DiffMono 143.058243 Formula C 9 H 14 N 2 O 4 S 1 MassAvg 246.28 MassMono 246.067428 Origin C Source artifact TermSpec none MOD:00631 MOD:00905 PSI-MOD MOD:01350 hydrolyzed N-ethylmaleimide lysine adduct modification from UniMod Chemical derivative - 320#K UniMod Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(N6-lysyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. Nethylmaleimide+water PSI-MS-label Nethylmaleimidehydrolysis UniMod-description DiffAvg 143.14 DiffFormula C 6 H 9 N 1 O 3 DiffMono 143.058243 Formula C 12 H 21 N 3 O 4 MassAvg 271.32 MassMono 271.153206 Origin K Source artifact TermSpec none MOD:00631 PSI-MOD MOD:01351 nitrated L-tryptophan A protein modification that effectively converts an L-tryptophan residue to a nitrated L-tryptophan. 8839040 PubMed 9252331 PubMed 354#W UniMod One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. Nitro PSI-MS-label nitrow OMSSA-label Oxidation to nitro UniMod-description DiffAvg 45.00 DiffFormula H -1 N 1 O 2 DiffMono 44.985078 Formula C 11 H 9 N 3 O 3 MassAvg 231.21 MassMono 231.064391 Origin W Source artifact TermSpec none MOD:00461 MOD:00918 PSI-MOD MOD:01352 nitrated L-tyrosine A protein modification that effectively converts an L-tyrosine residue to a nitrated L-tyrosine. 14678012 PubMed 8839040 PubMed 9252331 PubMed 354#Y UniMod One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. PSI-MOD-slim Nitro PSI-MS-label nitroy OMSSA-label Oxidation to nitro UniMod-description DiffAvg 45.00 DiffFormula H -1 N 1 O 2 DiffMono 44.985078 Formula C 9 H 8 N 2 O 4 MassAvg 208.17 MassMono 208.048407 Origin Y Source artifact TermSpec none MOD:00461 MOD:00919 PSI-MOD MOD:01353 amidination of lysines or N-terminal amines with methyl acetimidate - site K modification from UniMod Chemical derivative - 12643539 PubMed 15602776 PubMed 6273432 PubMed 141#K UniMod amidination of lysines or N-terminal amines with methyl acetimidate UniMod-description Amidine PSI-MS-label DiffAvg 41.05 DiffFormula C 2 H 3 N 1 DiffMono 41.026549 Formula C 8 H 15 N 3 O 1 MassAvg 169.23 MassMono 169.121512 Origin K Source artifact TermSpec none MOD:00509 MOD:00912 PSI-MOD MOD:01354 Hex1HexNAc1NeuAc1 N4-glycosylated asparagine A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. 11698400 PubMed 149#N UniMod Hex(1)HexNAc(1)NeuAc(1) PSI-MS-label Hex1HexNAc1NeuAc1 UniMod-description DiffAvg 657.60 DiffFormula C 25 H 41 N 2 O 18 DiffMono 657.235437 Formula C 29 H 47 N 4 O 20 MassAvg 771.70 MassMono 771.278365 Origin N Source natural TermSpec none MOD:00517 MOD:00903 PSI-MOD MOD:01355 Hex1HexNAc1NeuAc1O-glycosylated threonine A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. 149#T UniMod Hex(1)HexNAc(1)NeuAc(1) PSI-MS-label Hex1HexNAc1NeuAc1 UniMod-description DiffAvg 657.60 DiffFormula C 25 H 41 N 2 O 18 DiffMono 657.235437 Formula C 29 H 48 N 3 O 20 MassAvg 758.70 MassMono 758.283116 Origin T Source natural TermSpec none MOD:00517 MOD:00917 PSI-MOD MOD:01356 Hex1HexNAc1NeuAc1 O-glycosylated serine A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. 7856876 PubMed 149#S UniMod Hex(1)HexNAc(1)NeuAc(1) PSI-MS-label Hex1HexNAc1NeuAc1 UniMod-description DiffAvg 657.60 DiffFormula C 25 H 41 N 2 O 18 DiffMono 657.235437 Formula C 28 H 46 N 3 O 20 MassAvg 744.68 MassMono 744.267466 Origin S Source natural TermSpec none MOD:00517 MOD:00916 PSI-MOD MOD:01357 2x(13)C,4x(2)H labeled dimethylated L-lysine A protein modification that effectively replaces two hydrogen atoms of an L-lysine residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-lysine. 12686488 PubMed 16335955 PubMed 510#K UniMod DiMethyl-C13HD2 UniMod-description Dimethyl:2H(4)13C(2) PSI-MS-label DiffAvg 34.06 DiffFormula (13)C 2 (2)H 4 DiffMono 34.063117 Formula (12)C 6 (13)C 2 (1)H 12 (2)H 4 N 2 O 1 MassAvg 162.16 MassMono 162.158080 Origin K Source artifact TermSpec none MOD:00912 MOD:00927 derives_from MOD:000840 PSI-MOD MOD:01358 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site N-term modification from UniMod Isotopic label - Use when labelling post-digest 15602776 PubMed 687#N-term UniMod Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form UniMod-description ICPL:2H(4) PSI-MS-label DiffAvg 109.05 DiffFormula C 6 (1)H -1 (2)H 4 N 1 O 1 DiffMono 109.046571 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01426 PSI-MOD MOD:01359 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site K modification from UniMod Isotopic label - Use when labelling post-digest 15602776 PubMed 687#K UniMod Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form UniMod-description ICPL:2H(4) PSI-MS-label DiffAvg 109.05 DiffFormula C 6 (1)H -1 (2)H 4 N 1 O 1 DiffMono 109.046571 Formula C 12 (1)H 11 (2)H 4 N 3 O 2 MassAvg 237.14 MassMono 237.141534 Origin K Source artifact TermSpec none MOD:00912 MOD:01426 PSI-MOD MOD:01360 4-sulfophenyl isothiocyanate N6-derivatized lysine A protein modification that effectively converts an L-lysine residue to the 4-sulfophenyl isothiocyanate adduct, N6-[(4-sulfophenyl)carbamothioyl]lysine. 14689565 PubMed 14745769 PubMed 15549660 PubMed 16526082 PubMed 261#K UniMod 4-sulfophenyl isothiocyanate UniMod-description N6-[(4-sulfophenyl)carbamothioyl]lysine PSI-MOD-alternate SPITC PSI-MS-label DiffAvg 215.24 DiffFormula C 7 H 5 N 1 O 3 S 2 DiffMono 214.971085 Formula C 13 H 17 N 3 O 4 S 2 MassAvg 343.42 MassMono 343.066048 Origin K Source artifact TermSpec none MOD:00584 MOD:00912 PSI-MOD MOD:01361 O-thiophospho-L-threonine A protein modification that effectively converts an L-threonine residue to O-thiophospho-L-threonine. 11507762 PubMed 12110917 PubMed 260#T UniMod Thiophospho PSI-MS-label Thiophosphorylation UniMod-description DiffAvg 96.04 DiffFormula H 1 O 2 P 1 S 1 DiffMono 95.943487 Formula C 4 H 8 N 1 O 4 P 1 S 1 MassAvg 197.14 MassMono 196.991165 Origin T Source artifact TermSpec none MOD:00583 MOD:00917 PSI-MOD MOD:01362 O-thiophospho-L-serine A protein modification that effectively converts an L-serine residue to O-thiophospho-L-serine. 11507762 PubMed 12110917 PubMed 260#S UniMod Thiophospho PSI-MS-label Thiophosphorylation UniMod-description DiffAvg 96.04 DiffFormula H 1 O 2 P 1 S 1 DiffMono 95.943487 Formula C 3 H 6 N 1 O 4 P 1 S 1 MassAvg 183.12 MassMono 182.975515 Origin S Source artifact TermSpec none MOD:00583 MOD:00916 PSI-MOD MOD:01363 O4'-thiophospho-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-thiophospho-L-tyrosine. 12110917 PubMed 15549660 PubMed 260#Y UniMod Thiophospho PSI-MS-label Thiophosphorylation UniMod-description DiffAvg 96.04 DiffFormula H 1 O 2 P 1 S 1 DiffMono 95.943487 Formula C 9 H 10 N 1 O 4 P 1 S 1 MassAvg 259.22 MassMono 259.006815 Origin Y Source artifact TermSpec none MOD:00583 MOD:00919 PSI-MOD MOD:01364 fluorescein-5-thiosemicarbazide - site S modification from UniMod Chemical derivative - 11467524 PubMed 478#S UniMod fluorescein-5-thiosemicarbazide UniMod-description FTC PSI-MS-label DiffAvg 421.43 DiffFormula C 21 H 15 N 3 O 5 S 1 DiffMono 421.073242 Formula C 24 H 20 N 4 O 7 S 1 MassAvg 508.51 MassMono 508.105270 Origin S Source artifact TermSpec none MOD:00626 MOD:00916 PSI-MOD MOD:01365 fluorescein-5-thiosemicarbazide - site C modification from UniMod Chemical derivative - 478#C UniMod fluorescein-5-thiosemicarbazide UniMod-description FTC PSI-MS-label DiffAvg 421.43 DiffFormula C 21 H 15 N 3 O 5 S 1 DiffMono 421.073242 Formula C 24 H 20 N 4 O 6 S 2 MassAvg 524.57 MassMono 524.082426 Origin C Source artifact TermSpec none MOD:00626 MOD:00905 PSI-MOD MOD:01366 fluorescein-5-thiosemicarbazide - site K modification from UniMod Chemical derivative - 478#K UniMod fluorescein-5-thiosemicarbazide UniMod-description FTC PSI-MS-label DiffAvg 421.43 DiffFormula C 21 H 15 N 3 O 5 S 1 DiffMono 421.073242 Formula C 27 H 27 N 5 O 6 S 1 MassAvg 549.60 MassMono 549.168205 Origin K Source artifact TermSpec none MOD:00626 MOD:00912 PSI-MOD MOD:01367 fluorescein-5-thiosemicarbazide - site P modification from UniMod Chemical derivative - 478#P UniMod fluorescein-5-thiosemicarbazide UniMod-description FTC PSI-MS-label DiffAvg 421.43 DiffFormula C 21 H 15 N 3 O 5 S 1 DiffMono 421.073242 Formula C 26 H 22 N 4 O 6 S 1 MassAvg 518.54 MassMono 518.126005 Origin P Source artifact TermSpec none MOD:00626 MOD:00915 PSI-MOD MOD:01368 fluorescein-5-thiosemicarbazide - site R modification from UniMod Chemical derivative - 15525938 PubMed 478#R UniMod fluorescein-5-thiosemicarbazide UniMod-description FTC PSI-MS-label DiffAvg 421.43 DiffFormula C 21 H 15 N 3 O 5 S 1 DiffMono 421.073242 Formula C 27 H 27 N 7 O 6 S 1 MassAvg 577.62 MassMono 577.174353 Origin R Source artifact TermSpec none MOD:00626 MOD:00902 PSI-MOD MOD:01369 deamidated and methyl esterified residue A protein modification that effectively replaces a carboxamido group with a carboxyl methyl ester group. 528 UniMod PSI-MOD-slim Deamidation followed by a methylation UniMod-description Methyl+Deamidated PSI-MS-label DiffAvg 15.01 DiffFormula C 1 H 1 N -1 O 1 DiffMono 14.999666 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00393 MOD:00400 PSI-MOD MOD:01370 6x(13)C,1x(15)N labeled residue A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C,1x(15)N labeled residue. 11857757 PubMed 11999733 PubMed 12175151 PubMed 695 UniMod 13C(6) 15N(1) Silac label UniMod-description Label:13C(6)15N(1) PSI-MS-label DiffAvg 7.02 DiffFormula (12)C -6 (13)C 6 (14)N -1 (15)N 1 DiffMono 7.017164 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00842 MOD:00843 PSI-MOD MOD:01371 deamidation in presence of O18 OBSOLETE bcecause identical and redundant with MOD:00851. Remap to MOD:00851. 8382902 PubMed Deamidated:18O(1) PSI-MS-label Deamidation in presence of O18 UniMod-description DiffAvg 2.99 DiffFormula H -1 N -1 (18)O 1 DiffMono 2.988262 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none 1 PSI-MOD MOD:01372 (2S)-4-hydroxyleucine A protein modification that effectively converts an L-leucine residue to a (2S)-4-hydroxyleucine. 363352 PubMed 9164839 PubMed AA0442 RESID (2S)-2-amino-4-hydroxy-4-methylpentanoic acid RESID-systematic (2S)-4-hydroxyleucine RESID-name gamma-hydroxyleucine RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 11 N 1 O 2 MassAvg 129.16 MassMono 129.078979 Origin L Source natural TermSpec none MOD:01411 PSI-MOD MOD:01373 (2S,4R)-5-hydroxyleucine A protein modification that effectively converts an L-leucine residue to a (2S,4R)-5-hydroxyleucine. 16858410 PubMed 7690768 PubMed 9164839 PubMed AA0443 RESID (2S,4R)-2-amino-5-hydroxy-4-methylpentanoic acid RESID-systematic (2S,4R)-5-hydroxyleucine RESID-name (4R)-5-hydroxyleucine RESID-alternate delta-hydroxyleucine RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 11 N 1 O 2 MassAvg 129.16 MassMono 129.078979 Origin L Source hypothetical TermSpec none MOD:01411 PSI-MOD MOD:01374 (2S,4R)-5-oxoleucine A modification that effectively oxygenates C5 of an L-leucine residue to form a (2S,4R)-5-oxoleucine. 43739 ChEBI 16858410 PubMed AA0444 RESID (2S,4R)-2-amino-4-methyl-5-oxopentanoic acid RESID-systematic (2S,4R)-5-oxoleucine RESID-name (4R)-5-oxo-L-leucine RESID-alternate DiffAvg 13.98 DiffFormula C 0 H -2 N 0 O 1 DiffMono 13.979265 Formula C 6 H 9 N 1 O 2 MassAvg 127.14 MassMono 127.063329 Origin L Source hypothetical TermSpec none MOD:00679 MOD:00911 PSI-MOD MOD:01375 (2S,4R)-4,5-dihydroxyleucine A protein modification that effectively converts an L-leucine residue to a (2S,4R)-4,5-dihydroxyleucine. 6010785 PubMed 6893271 PubMed AA0445 RESID (2S,4R)-2-amino-4,5-dihydroxy-4-methylpentanoic acid RESID-systematic (2S,4R)-4,5-dihydroxyleucine RESID-name (4R)-4,5-dihydroxyleucine RESID-alternate gamma,delta-dihydroxyleucine RESID-alternate MOD_RES (4R)-4,5-dihydroxyleucine UniProt-feature DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 6 H 11 N 1 O 3 MassAvg 145.16 MassMono 145.073893 Origin L Source natural TermSpec none MOD:01412 PSI-MOD MOD:01376 (2S,3S,4R)-3,4-dihydroxyisoleucine A protein modification that effectively converts an L-isoleucine residue to a (2S,3S,4R)-3,4-dihydroxyisoleucine. 11320328 PubMed AA0447 RESID (2S,3S,4R)-2-amino-3,4-dihydroxy-3-methylpentanoic acid RESID-systematic (2S,3S,4R)-3,4-dihydroxyisoleucine RESID-name (3S,4R)-3,4-dihydroxyisoleucine RESID-alternate beta,gamma-dihydroxyisoleucine RESID-alternate MOD_RES (3S,4R)-3,4-dihydroxyisoleucine UniProt-feature DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 6 H 11 N 1 O 3 MassAvg 145.16 MassMono 145.073893 Origin I Source natural TermSpec none MOD:01416 PSI-MOD MOD:01377 (2S,3R,4S)-4-hydroxyisoleucine A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4S)-4-hydroxyisoleucine. 363352 PubMed AA0448 RESID (2S,3R,4S)-2-amino-3-methyl-4-hydroxyvaleric acid RESID-alternate (2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acid RESID-systematic (2S,3R,4S)-4-hydroxyisoleucine RESID-name (3R,4S)-4-hydroxyisoleucine RESID-alternate gamma-hydroxyisoleucine RESID-alternate MOD_RES (3R,4S)-4-hydroxyisoleucine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 11 N 1 O 2 MassAvg 129.16 MassMono 129.078979 Origin I Source natural TermSpec none MOD:01415 PSI-MOD MOD:01378 (2S,3R,4R)-4,5-dihydroxyisoleucine A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4R)-4,5-dihydroxyisoleucine. 11805306 PubMed 18552824 PubMed 363352 PubMed AA0449 RESID (2S,3R,4R)-2-amino-4,5-dihydroxy-3-methylpentanoic acid RESID-systematic (2S,3R,4R)-4,5-dihydroxyisoleucine RESID-name (3R,4R)-4,5-dihydroxyisoleucine RESID-alternate gamma,delta-dihydroxyisoleucine RESID-alternate MOD_RES (3R,4R)-4,5-dihydroxyisoleucine UniProt-feature DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 6 H 11 N 1 O 3 MassAvg 145.16 MassMono 145.073893 Origin I Source natural TermSpec none MOD:01416 PSI-MOD MOD:01379 2'-methylsulfonyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 2'-methylsulfonyl-L-tryptophan. 6893271 PubMed AA0450 RESID 2'-methylsulfonyl-L-tryptophan RESID-name 2-methylsulfonyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole RESID-systematic MOD_RES 2'-methylsulfonyltryptophan UniProt-feature DiffAvg 78.09 DiffFormula C 1 H 2 N 0 O 2 S 1 DiffMono 77.977550 Formula C 12 H 12 N 2 O 3 S 1 MassAvg 264.30 MassMono 264.056863 Origin W Source natural TermSpec none MOD:00918 PSI-MOD MOD:01380 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide. 11805306 PubMed 18552824 PubMed 363352 PubMed 4865716 PubMed AA0451 RESID Cross-link 2. 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide RESID-name 2-((2R)-2-amino-2carboxyethyl)sulfinyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole RESID-systematic 6'-hydroxy-S-oxo-tryptathionine RESID-alternate CROSSLNK 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys) UniProt-feature DiffAvg 29.98 DiffFormula C 0 H -2 N 0 O 2 S 0 DiffMono 29.974179 Formula C 14 H 13 N 3 O 4 S 1 MassAvg 319.33 MassMono 319.062677 Origin C, W Source natural TermSpec none MOD:00687 MOD:00918 PSI-MOD MOD:01381 O-palmitoleyl-L-serine A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine. 17141155 PubMed AA0455 RESID PSI-MOD-slim (2S)-2-amino-3-((9Z)-9-hexadecenoyloxy)propanoic acid RESID-systematic L-serine cis-9-hexadecenoate ester RESID-alternate LIPID O-palmitoleyl serine UniProt-feature mod186 OMSSA-label O-palmitoleyl-L-serine RESID-name O3-palmitoleyl-serine RESID-alternate DiffAvg 236.40 DiffFormula C 16 H 28 N 0 O 1 DiffMono 236.214016 Formula C 19 H 33 N 1 O 3 MassAvg 323.48 MassMono 323.246044 Origin S Source natural TermSpec none MOD:00916 MOD:01768 PSI-MOD MOD:01382 N,N,N-trimethyl-L-methionine A protein modification that effectively converts an L-methionine residue to N,N,N-trimethyl-L-methionine. 18611379 PubMed AA0456 RESID PSI-MOD-slim (1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanaminium RESID-systematic (1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanazanium RESID-alternate 2-trimethylammonio-4-(methylthio)butanoic acid RESID-alternate MOD_RES N,N,N-trimethylmethionine UniProt-feature N,N,N-trimethyl-L-methionine RESID-name N,N,N-trimethylmethionine cation RESID-alternate N,N,N-trimethylmethioninium RESID-alternate N2Me3+Met PSI-MOD-label DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 S 0 DiffMono 43.054227 FormalCharge 1+ Formula C 8 H 17 N 1 O 1 S 1 MassAvg 175.29 MassMono 175.102537 Origin M Source natural TermSpec N-term MOD:01463 MOD:01698 PSI-MOD MOD:01383 L-cystine S-oxide A protein modification that effectively cross-links two L-cysteine residues and oxidizes a sulfur to form L-cystine S-oxide. AA0457 RESID Cross-link 2. (2R)-2-amino-3-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)sulfinyl]propanoic acid RESID-systematic CROSSLNK S-cysteinyl 3-(oxidosulfanyl)alanine (Cys-Cys) UniProt-feature cystine sulfoxide RESID-alternate L-cystine S-oxide RESID-name S-[(2R)-2-amino-3-oxopropyl] (2R)-2-amino-3-oxopropane-1-sulfinothioate RESID-alternate S-cysteinyl 3-(oxidosulfanyl)alanine RESID-alternate DiffAvg 13.98 DiffFormula C 0 H -2 N 0 O 1 S 0 DiffMono 13.979265 Formula C 6 H 8 N 2 O 3 S 2 MassAvg 220.26 MassMono 219.997634 Origin C, C Source hypothetical TermSpec none MOD:00689 PSI-MOD MOD:01384 aminomalonic acid (Ser) A protein modification that effectively converts an L-serine residue to an aminomalonic acid. 1621954 PubMed 5415959 PubMed 6366787 PubMed 7457858 PubMed AA0458 RESID 2-carboxyglycine RESID-alternate Ama RESID-alternate aminomalonic acid RESID-name aminopropanedioic acid RESID-systematic MOD_RES Aminomalonic acid (Ser) UniProt-feature DiffAvg 13.98 DiffFormula C 0 H -2 N 0 O 1 S 0 DiffMono 13.979265 Formula C 3 H 3 N 1 O 3 MassAvg 101.06 MassMono 101.011293 Origin S Source hypothetical TermSpec none MOD:00916 PSI-MOD MOD:01385 3-hydroxy-L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to 3-hydroxy-L-phenylalanine. 16795 ChEBI 10625477 PubMed 15651011 PubMed 16734421 PubMed 1880060 PubMed 7398618 PubMed 7844053 PubMed AA0462 RESID (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid RESID-systematic 3-hydoxyphenylalanine RESID-alternate 3-hydroxy-L-phenylalanine RESID-name 3-phenyl-L-serine RESID-alternate 3HyPhe PSI-MOD-label beta-hydroxyphenylalanine RESID-alternate beta-phenylserine RESID-alternate hydroxylationf OMSSA-label L-threo-3-phenylserine RESID-alternate MOD_RES 3-hydroxyphenylalanine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 9 H 9 N 1 O 2 MassAvg 163.18 MassMono 163.063329 Origin F Source natural TermSpec none MOD:00677 MOD:00914 PSI-MOD MOD:01386 3-hydroxy-L-valine A protein modification that effectively converts an L-valine residue to 3-hydroxy-L-valine. 7328054 PubMed AA0463 RESID (2S)-2-amino-3-hydroxy-3-methylbutanoic acid RESID-systematic 3-hydroxy-L-valine RESID-name 3-hydroxyvaline RESID-alternate 3HyVal PSI-MOD-label MOD_RES 3-hydroxyvaline UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 9 N 1 O 2 MassAvg 115.13 MassMono 115.063329 Origin V Source natural TermSpec none MOD:00677 MOD:00920 PSI-MOD MOD:01387 O-methyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-methyl-L-threonine. 7328054 PubMed AA0464 RESID (2S,3R)-2-amino-3-methoxybutanoic acid RESID-systematic MOD_RES O-methylthreonine UniProt-feature O-methyl threonine RESID-alternate O-methyl-L-threonine RESID-name OMeThr PSI-MOD-label threonine methyl ether RESID-alternate DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 5 H 9 N 1 O 2 MassAvg 115.13 MassMono 115.063329 Origin T Source natural TermSpec none MOD:01803 PSI-MOD MOD:01388 1-amino-2-propanol A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanol. 15675 ChEBI 7328054 PubMed AA0465 RESID (2R)-1-aminopropan-2-ol RESID-systematic 1-amino-2-hydroxypropane RESID-alternate 1-amino-2-propanol RESID-name 1-methyl-2-aminoethanol RESID-alternate 2-amino-1-methylethanol RESID-alternate 2-hydroxy-1-propylamine RESID-alternate 2-hydroxypropanamine RESID-alternate 2-hydroxypropylamine RESID-alternate alpha-aminoisopropyl alcohol RESID-alternate dCbxThr PSI-MOD-label decarboxylated threonine RESID-alternate isopropanolamine RESID-alternate MOD_RES Decarboxylated threonine UniProt-feature threamine RESID-alternate DiffAvg -44.01 DiffFormula C -1 H 0 N 0 O -2 DiffMono -43.989829 Formula C 3 H 8 N 1 O 1 MassAvg 74.10 MassMono 74.060589 Origin T Source natural TermSpec C-term MOD:00917 MOD:00960 PSI-MOD MOD:01389 L-isoleucine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-isoleucine residue to form L-isoleucine thiazole-4-carboxylic acid. 11320328 PubMed AA0466 RESID Cross-link 2. 2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-zanyl-2-methylbutyl]-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Ile-Cys) UniProt-feature L-isoleucine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 9 H 12 N 2 O 1 S 1 MassAvg 196.27 MassMono 196.067034 Origin C, I Source natural TermSpec none MOD:00910 MOD:01420 MOD:01888 PSI-MOD MOD:01390 L-valine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue to form L-valine thiazole-4-carboxylic acid. 7328054 PubMed AA0467 RESID Cross-link 2. 2-[(1S)-1-amino-2-methylpropyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-methylpropyl]-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Val-Cys) UniProt-feature L-valine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 8 H 10 N 2 O 1 S 1 MassAvg 182.24 MassMono 182.051384 Origin C, V Source natural TermSpec none MOD:00920 MOD:01420 MOD:01888 PSI-MOD MOD:01391 L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue, and C-5 methoxymethylates to form L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid. 10625477 PubMed 1880060 PubMed 7844053 PubMed AA0468 RESID Cross-link 2. 2-[(1S)-1-amino-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK 5-(methoxymethyl)thiazole-4-carboxylic acid (Val-Cys) UniProt-feature L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid RESID-name DiffAvg 24.02 DiffFormula C 2 H 0 N 0 O 0 S 0 DiffMono 24.000000 Formula C 10 H 14 N 2 O 2 S 1 MassAvg 226.29 MassMono 226.077599 Origin C, V Source natural TermSpec none MOD:00920 MOD:01420 MOD:01888 PSI-MOD MOD:01392 L-asparagine 5-methylthiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue, and C-4 methylates to form L-asparagine 5-methylthiazole-4-carboxylic acid. 10625477 PubMed 1880060 PubMed 7844053 PubMed AA0469 RESID Cross-link 2. 2-[(1S)-1,3-bisazanyl-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid RESID-alternate 2-[(1S)-1,3-diamino-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid RESID-systematic CROSSLNK 5-methylthiazole-4-carboxylic acid (Asn-Cys) UniProt-feature L-asparagine 5-methylthiazole-4-carboxylic acid RESID-name DiffAvg -6.00 DiffFormula C 1 H -2 N 0 O -1 S 0 DiffMono -6.010565 Formula C 8 H 9 N 3 O 2 S 1 MassAvg 211.24 MassMono 211.041548 Origin C, N Source natural TermSpec none MOD:00903 MOD:01420 MOD:01888 derives_from MOD:006560 PSI-MOD MOD:01393 L-cysteine pyridine-2,5-dicarboxylic acid A protein modification that crosslinks two serine residues and a cysteine residue by formation of a pyridine-2,5-dicarboxylic acid. 10625477 PubMed 1880060 PubMed 7844053 PubMed AA0470 RESID Cross-link 3. 6-[(1R)-1-amino-2-sulfanylethyl]pyridine-2,5-dicarboxylic acid RESID-systematic L-cysteine pyridine-2,5-dicarboxylic acid RESID-name DiffAvg -70.07 DiffFormula C 0 H -8 N -1 O -3 S 0 DiffMono -70.050418 Formula C 9 H 7 N 2 O 2 S 1 MassAvg 207.23 MassMono 207.022823 Origin C, S, S Source natural TermSpec none MOD:01425 PSI-MOD MOD:01394 L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid A protein modification that crosslinks two serine residues and a cysteine residue by formation of a 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid. 11320328 PubMed AA0471 RESID Cross-link 3. (5R,6R)-5-amino-6-[(1R)-1-amino-2-sulfanylethyl]-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid RESID-systematic L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid RESID-name L-cysteine 5-aminopiperideine-2,5-dicarboxylic acid RESID-alternate DiffAvg -53.04 DiffFormula C 0 H -5 N 0 O -3 S 0 DiffMono -53.023869 Formula C 9 H 11 N 3 O 2 S 1 MassAvg 225.27 MassMono 225.057198 Origin C, S, S Source natural TermSpec N-term MOD:01425 PSI-MOD MOD:01395 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol A protein modification that effectively results from forming an adduct between an isoleucine residue, a threonine residue and the quinaldate compound 2-carboxy-4-(1-hydroxyethyl)--7,8-dihydroquinolin-8-ol. 11320328 PubMed AA0472 RESID Cross-link 2. (7R,8S)-7-[(1S,2S)-1-carboxy-2-methylbutyl]amino-2-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)carbonyl-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7,8-dihydroquinoline RESID-systematic 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol RESID-name BINDING 4-(1-hydroxyethyl)-7,8-dihydroquinolin-8-ol (covalent; via 2 links) UniProt-feature DiffAvg 215.21 DiffFormula C 12 H 9 N 1 O 3 DiffMono 215.058243 Formula C 22 H 28 N 3 O 6 MassAvg 430.48 MassMono 430.197811 Origin I, T Source natural TermSpec N-term MOD:00910 MOD:00917 MOD:01424 PSI-MOD MOD:01396 5-hydroxy-3-methyl-L-proline (Pro) A protein modification that effectively converts an L-proline residue to a 5-hydroxy-3-methyl-L-proline. 7592021 PubMed 8557573 PubMed AA0473 RESID This entry is for the hypothetical formation of 5-hydroxy-3-methyl-L-proline from proline. For the natural production from L-isoleucine, use MOD:01897 [JSG]. (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid RESID-systematic 5-hydroxy-3-methyl-L-proline RESID-name 5-hydroxy-3-methylproline RESID-alternate 5Hy3MePro PSI-MOD-label beta-methyl-delta-hydroxyproline RESID-alternate MOD_RES 5-hydroxy-3-methylproline (Ile) UniProt-feature DiffAvg 30.03 DiffFormula C 1 H 2 N 0 O 1 DiffMono 30.010565 Formula C 6 H 9 N 1 O 2 MassAvg 127.14 MassMono 127.063329 Origin P Source artifactual TermSpec none MOD:00915 has_functional_parent MOD:010240 has_functional_parent MOD:014170 PSI-MOD MOD:01397 L-serine 5-methyloxazole-4-carboxylic acid A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazole-4-carboxylic acid. 7592021 PubMed 8557573 PubMed AA0474 RESID Cross-link 2. 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid RESID-alternate CROSSLNK 5-methyloxazole-4-carboxylic acid (Ser-Thr) UniProt-feature L-serine 5-methyloxazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 DiffMono -20.026215 Formula C 7 H 8 N 2 O 3 MassAvg 168.15 MassMono 168.053492 Origin S, T Source natural TermSpec none MOD:00916 MOD:01422 MOD:01888 PSI-MOD MOD:01398 N6-propanoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-propanoyl-L-lysine. 17267393 PubMed 17684016 PubMed 20715035 PubMed AA0475 RESID 58#K UniMod The binding of histone peptides with propanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. PSI-MOD-slim (2S)-2-amino-6-(propanoylamino)hexanoic acid RESID-systematic 2-amino-6-propionylaminocaproic acid RESID-alternate epsilon-propanoyl-L-lysine RESID-alternate epsilon-propionyl-L-lysine RESID-alternate N(zeta)-propanoyllysine RESID-alternate N6-(1-oxopropyl)-L-lysine RESID-alternate N6-propanoyl-L-lysine RESID-name N6-propionyllysine RESID-alternate DiffAvg 56.06 DiffFormula C 3 H 4 N 0 O 1 DiffMono 56.026215 Formula C 9 H 16 N 2 O 2 MassAvg 184.24 MassMono 184.121178 Origin K Source natural TermSpec none MOD:01155 MOD:01875 MOD:01894 PSI-MOD MOD:01399 N6-(ADP-ribosyl)-L-lysine A protein modification that effectively converts an L-lysine residue to an N6-(ADP-ribosyl)-L-lysine. 18436469 PubMed AA0476 RESID (S)-2-amino-6-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)hexanoic acid RESID-systematic 2-amino-6-(ADP-ribosyl)amino-hexanoic acid RESID-alternate epsilon-ADP-ribosyllysine RESID-alternate MOD_RES N6-(ADP-ribosyl)lysine UniProt-feature N(zeta)-ADP-ribosyllysine RESID-alternate N6-(ADP-ribosyl)-L-lysine RESID-name N6-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-lysine RESID-alternate N6-alpha-D-ribofuranosyl-L-lysine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) RESID-alternate DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 21 H 33 N 7 O 14 P 2 MassAvg 669.48 MassMono 669.156072 Origin K Source hypothetical TermSpec none MOD:00752 MOD:00912 PSI-MOD MOD:01400 L-lysyl-poly(ADP-ribose) A protein modification that effectively converts an L-lysine residue to an L-lysyl-poly(ADP-ribose). 6772638 PubMed AA0477 RESID L-lysyl-poly(ADP-ribose) RESID-name MOD_RES Lysyl poly(ADP-ribose) UniProt-feature poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl] (2S)-2,6-diaminohexanoate RESID-systematic DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 21 H 34 N 7 O 15 P 2 MassAvg 686.48 MassMono 686.158812 Origin K Source natural TermSpec C-term MOD:00752 MOD:00912 PSI-MOD MOD:01401 (2S,3S)-3-hydroxyasparagine A protein modification that effectively converts an L-asparagine residue to a (2S,3S)-3-hydroxyasparagine. 50789 ChEBI 11823643 PubMed 12042299 PubMed 12215170 PubMed 17573339 PubMed AA0478 RESID PSI-MOD-slim (2S,3S)-2,4-diamino-3-hydroxy-4-oxobutanoic acid RESID-alternate (2S,3S)-2-amino-3-hydroxy-4-butanediamic acid RESID-systematic (2S,3S)-3-hydroxyasparagine RESID-name (3S)3HyAsn PSI-MOD-label L-threo-beta-hydroxyasparagine RESID-alternate MOD_RES (3S)-3-hydroxyasparagine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 4 H 6 N 2 O 3 MassAvg 130.10 MassMono 130.037842 Origin N Source natural TermSpec none MOD:01688 PSI-MOD MOD:01402 (2S,3R,4R)-3,4-dihydroxyproline A protein modification that effectively converts an L-proline residue to a (2S,3R,4R)-3,4-dihydroxyproline. 6893271 PubMed AA0479 RESID (2S,3R,4R)-3,4-dihydroxyproline RESID-name (2S,3R,4R)-3,4-dihydroxypyrrolidine-2-carboxylic acid RESID-systematic 2,3-trans-3,4-trans-3,4-dihydroxy-L-proline RESID-alternate 2-alpha-3-beta-4-alpha-3,4-dihydroxyproline RESID-alternate MOD_RES (3R,4R)-3,4-dihydroxyproline UniProt-feature DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin P Source natural TermSpec none MOD:00866 PSI-MOD MOD:01403 (2S)-4,5,5'-trihydroxyleucine A protein modification that effectively converts an L-leucine residue to a (2S)-4,5,5'-trihydroxyleucine. 6893271 PubMed AA0480 RESID (2S)-2-amino-4,5-dihydroxy-4-(hydroxymethyl)pentanoic acid RESID-systematic (2S)-4,5,5'-trihydroxyleucine RESID-name 4,5,5'-trihydroxyleucine RESID-alternate gamma,delta,delta'-trihydroxyleucine RESID-alternate MOD_RES 4,5,4'-trihydroxyleucine UniProt-feature DiffAvg 48.00 DiffFormula C 0 H 0 N 0 O 3 DiffMono 47.984744 Formula C 6 H 11 N 1 O 4 MassAvg 161.16 MassMono 161.068808 Origin L Source natural TermSpec none MOD:01413 PSI-MOD MOD:01404 L-asparagine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue to form L-asparagine thiazole-4-carboxylic acid. 7592021 PubMed 8557573 PubMed AA0481 RESID Cross-link 2. 2-[(1S)-1,3-diamino-3-oxopropyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1,3-bisazanyl-3-oxopropyl]-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Asn-Cys) UniProt-feature L-asparagine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 7 H 7 N 3 O 2 S 1 MassAvg 197.21 MassMono 197.025897 Origin C, N Source natural TermSpec none MOD:00903 MOD:01420 MOD:01888 PSI-MOD MOD:01405 L-proline thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-proline residue to form L-proline thiazole-4-carboxylic acid. 7592021 PubMed 8557573 PubMed AA0482 RESID Cross-link 2. 2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid RESID-systematic CROSSLNK Thiazole-4-carboxylic acid (Pro-Cys) UniProt-feature L-proline thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 8 H 8 N 2 O 1 S 1 MassAvg 180.22 MassMono 180.035734 Origin C, P Source natural TermSpec none MOD:00915 MOD:01420 MOD:01888 PSI-MOD MOD:01406 L-threonine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazole-4-carboxylic acid. 11320328 PubMed AA0483 RESID Cross-link 2. 2-[(1S,2R)-1-amino-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Thr-Cys) UniProt-feature L-threonine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 7 H 8 N 2 O 2 S 1 MassAvg 184.21 MassMono 184.030649 Origin C, T Source natural TermSpec none MOD:00917 MOD:01420 MOD:01888 PSI-MOD MOD:01407 L-phenylalanine thiazoline-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazoline-4-carboxylic acid. 7592021 PubMed 8557573 PubMed AA0484 RESID Cross-link 2. (4R)-2-[(1S)-1-amino-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazoline-4-carboxylic acid (Phe-Cys) UniProt-feature L-phenylalanine thiazoline-4-carboxylic acid RESID-name DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 12 H 12 N 2 O 1 S 1 MassAvg 232.30 MassMono 232.067034 Origin C, F Source natural TermSpec none MOD:00914 MOD:01420 PSI-MOD MOD:01408 L-threonine thiazoline-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazoline-4-carboxylic acid. 11320328 PubMed AA0485 RESID Cross-link 2. (4S)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[1-azanyl-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK (4S)-thiazoline-4-carboxylic acid (Thr-Cys) UniProt-feature L-threonine (4S)-thiazoline-4-carboxylic acid RESID-name DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 7 H 10 N 2 O 2 S 1 MassAvg 186.23 MassMono 186.046299 Origin C, T Source natural TermSpec none MOD:00917 MOD:01420 PSI-MOD MOD:01409 trihydroxylated residue A protein modification that effectively replaces three hydrogen atoms with three hydroxyl groups. 18688235 PubMed Hy3Res PSI-MOD-label DiffAvg 48.00 DiffFormula C 0 H 0 N 0 O 3 DiffMono 47.984744 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00677 PSI-MOD MOD:01410 hydroxylated leucine A protein modification that effectively converts an L-leucine residue to an hydroxylated leucine. 18688235 PubMed HyLeu PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin L Source none TermSpec none MOD:00677 MOD:00911 PSI-MOD MOD:01411 monohydroxylated leucine A protein modification that effectively converts an L-leucine residue to a monohydroxylated leucine. 18688235 PubMed Hy1Leu PSI-MOD-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 11 N 1 O 2 MassAvg 129.16 MassMono 129.078979 Origin L Source natural TermSpec none MOD:00425 MOD:01410 PSI-MOD MOD:01412 dihydroxylated leucine A protein modification that effectively converts an L-leucine residue to a dihydroxylated leucine. 18688235 PubMed Hy2Leu PSI-MOD-label DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 6 H 11 N 1 O 3 MassAvg 145.16 MassMono 145.073893 Origin L Source natural TermSpec none MOD:00428 MOD:01410 PSI-MOD MOD:01413 trihydroxylated leucine A protein modification that effectively converts an L-leucine residue to a trihydroxylated leucine. 18688235 PubMed Hy3Leu PSI-MOD-label DiffAvg 48.00 DiffFormula C 0 H 0 N 0 O 3 DiffMono 47.984744 Formula C 6 H 11 N 1 O 4 MassAvg 161.16 MassMono 161.068808 Origin L Source natural TermSpec none MOD:01409 MOD:01410 PSI-MOD MOD:01414 hydroxylated isoleucine A protein modification that effectively converts an L-isoleucine residue to an hydroxylated isoleucine. 18688235 PubMed HyIle PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin I Source none TermSpec none MOD:00677 MOD:00910 PSI-MOD MOD:01415 monohydroxylated isoleucine A protein modification that effectively converts an L-isoleucine residue to a monohydroxylated isoleucine. 18688235 PubMed Hy1Ile PSI-MOD-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 11 N 1 O 2 MassAvg 129.16 MassMono 129.078979 Origin I Source natural TermSpec none MOD:00425 MOD:01414 PSI-MOD MOD:01416 dihydroxylated isoleucine A protein modification that effectively converts an L-isoleucine residue to a dihydroxylated isoleucine. 18688235 PubMed Hy2Ile PSI-MOD-label DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 6 H 11 N 1 O 3 MassAvg 145.16 MassMono 145.073893 Origin I Source natural TermSpec none MOD:00428 MOD:01414 PSI-MOD MOD:01417 monomethylated proline A protein modification that effectively converts an L-proline residue to a monomethylated proline. 18688235 PubMed PSI-MOD-slim Me1Pro PSI-MOD-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 6 H 10 N 1 O 1 MassAvg 112.15 MassMono 112.076239 Origin P Source natural TermSpec none MOD:00599 MOD:00712 PSI-MOD MOD:01418 methylated threonine A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine. 18688235 PubMed MeThr PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin T Source natural TermSpec none MOD:00427 MOD:00917 PSI-MOD MOD:01419 oxazole/oxazoline ring crosslinked residues A protein modification that crosslinks two residues by condensation of a serine or threonine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring, or by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid. 18688235 PubMed MOD:00690 PSI-MOD MOD:01420 thiazole/thiazoline ring croslinked residues A protein modification that crosslinks two residues by condensation of a cysteine thiol with the carbonyl of the preceding residue to form a thiazole or thiazoline ring. 18688235 PubMed DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source natural TermSpec none MOD:00687 MOD:00690 PSI-MOD MOD:01421 oxazole/oxazoline ring crosslinked residues (Ser) A protein modification that crosslinks two residues by condensation of a serine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring. 18688235 PubMed DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin S Source natural TermSpec none MOD:00916 MOD:01419 PSI-MOD MOD:01422 oxazole/oxazoline ring crosslinked residues (Thr) A protein modification that crosslinks two residues by condensation of a threonine hydroxyl with the carbonyl of the preceding residue to form a 5-methyloxazole or 5-methyloxazoline ring. 18688235 PubMed DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin T Source natural TermSpec none MOD:00917 MOD:01419 PSI-MOD MOD:01423 palmitoleylated residue A protein modification that effectively replaces a hydrogen atom with a palmitoleyl group. 431 UniMod PSI-MOD-slim DiffAvg 236.40 DiffFormula C 16 H 28 N 0 O 1 DiffMono 236.214016 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00649 PSI-MOD MOD:01424 quinaldate modified residue A protein modification that effectively results from forming an adduct with a compound containing a quinaldate, kynurenate, or xanthurenate group. 18688235 PubMed MOD:01156 PSI-MOD MOD:01425 pyridinyl ring crosslinked residues A protein modification that crosslinks three residues by formation of a pyridinyl ring, such as pyridine-2,5-dicarboxylic acid or 5-aminopiperideine-2,5-dicarboxylic acid. 18688235 PubMed Cross-link 3. DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C, S, S Source natural TermSpec none MOD:00033 MOD:00905 MOD:00916 PSI-MOD MOD:01426 isotope tagged reagent derivatized residue A protein modification that forms an adduct with a particular isotope labeled compound used as a reagent. 18688235 PubMed PSI-MOD-slim MOD:00848 PSI-MOD MOD:01427 2-aminobutanoic acid (Abu) OBSOLETE because redundant and identical to MOD:00819. Remap to MOD:00819. 18688235 PubMed Abu DeltaMass-label DiffAvg none DiffFormula none DiffMono none Formula C 4 H 7 N 1 O 1 MassAvg 85.11 MassMono 85.052764 Origin X Source artifact TermSpec none 1 PSI-MOD MOD:01428 (13)C isotope tagged reagent A protein modification that forms an adduct with a (13)C labeled compound used as a reagent. 18688235 PubMed PSI-MOD-slim MOD:01426 PSI-MOD MOD:01429 (15)N isotope tagged reagent A protein modification that forms an adduct with a (15)N labeled compound used as a reagent. 18688235 PubMed PSI-MOD-slim MOD:01426 PSI-MOD MOD:01430 (18)O isotope tagged reagent A protein modification that forms an adduct with a (13)C labeled compound used as a reagent. 18688235 PubMed PSI-MOD-slim MOD:01426 PSI-MOD MOD:01431 (2)H deuterium tagged reagent A protein modification that forms an adduct with a (2)H labeled compound used as a reagent. 18688235 PubMed PSI-MOD-slim MOD:01426 PSI-MOD MOD:01432 (2S,4S)-4,5-dihydroxyleucine A protein modification that effectively converts an L-leucine residue to a (2S,4S)-4,5-dihydroxyleucine. 3718926 PubMed AA0446 RESID (2S,4S)-2-amino-4,5-dihydroxy-4-methylpentanoic acid RESID-systematic (2S,4S)-4,5-dihydroxyleucine RESID-name (4S)-4,5-dihydroxyleucine RESID-alternate gamma,delta-dihydroxyleucine RESID-alternate DiffAvg 32.00 DiffFormula C 0 H 0 N 0 O 2 DiffMono 31.989829 Formula C 6 H 11 N 1 O 3 MassAvg 145.16 MassMono 145.073893 Origin L Source natural TermSpec none MOD:01412 PSI-MOD MOD:01433 1-amino-2-propanone A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanone. 17906 ChEBI 12715872 PubMed 19196969 PubMed AA0486 RESID 1-amino-2-propanone RESID-name 1-aminopropan-2-one RESID-alternate 1-aminopropanone RESID-systematic aminoacetone RESID-alternate MOD_RES 1-amino-2-propanone UniProt-feature DiffAvg -46.03 DiffFormula C -1 H -2 N 0 O -2 DiffMono -46.005479 Formula C 3 H 6 N 1 O 1 MassAvg 72.09 MassMono 72.044939 Origin T Source natural TermSpec C-term MOD:00683 MOD:00917 MOD:00960 PSI-MOD MOD:01434 4-hydroxy-L-glutamic acid A protein modification that effectively converts an L-glutamic acid residue to a 4-hydroxy-L-glutamic acid. 893891 PubMed AA0487 RESID (2S,4Xi)-2-amino-4-hydroxypentanedioic acid RESID-systematic 4-hydroxy-L-glutamic acid RESID-name gamma-hydroxy glutaminic acid RESID-alternate MOD_RES 4-hydroxyglutamate UniProt-feature threo-4-hydroxy-L-glutamic acid RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 7 N 1 O 4 MassAvg 145.11 MassMono 145.037508 Origin E Source natural TermSpec none MOD:00425 MOD:00906 PSI-MOD MOD:01435 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole A protein modification that effectively results from forming an adduct between a cysteine residue, a glutamic acid residue and the indole compound 2-carboxy-3-methyl-4-hydroxymethyl--indole. 893891 PubMed AA0488 RESID Cross-link 2. 2-([(1R)-1-amino-1-carboxyeth-2-yl]sulfanyl)carbonyl-3-methyl-4-([(1S)-1-amino-1-carboxy-4-oxobutan-4-yl]oxy)methyl-1H-indole RESID-systematic 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole RESID-name 2-(cystein-S-ylcarbonyl)-4-[(glutam-5-yloxy)methyl]-3-methyl-1H-indole RESID-alternate BINDING 3-methyl-4-hydroxymethylindole-2-carboxylic acid (covalent; via 2 links) UniProt-feature DiffAvg 169.18 DiffFormula C 11 H 7 N 1 O 1 S 0 DiffMono 169.052764 Formula C 19 H 19 N 3 O 5 S 1 MassAvg 401.44 MassMono 401.104542 Origin C, E Source natural TermSpec none MOD:00672 MOD:00905 MOD:00906 PSI-MOD MOD:01436 cyclo[(prolylserin)-O-yl] cysteinate (Cys) A protein modification that effectively converts an L-cysteine residue to cyclo[(prolylserin)-O-yl] cysteinate. 7961166 PubMed AA0489#CYS RESID (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate RESID-alternate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate RESID-systematic cyclo[(prolylserin)-O-yl] cysteinate RESID-name MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate UniProt-feature DiffAvg 166.18 DiffFormula C 8 H 10 N 2 O 2 S 0 DiffMono 166.074228 Formula C 11 H 16 N 3 O 4 S 1 MassAvg 286.33 MassMono 286.086152 Origin C Source natural TermSpec C-term MOD:01629 PSI-MOD MOD:01437 cyclo[(prolylserin)-O-yl] cysteinate (Cys-Pro-Ser cross-link) A protein modification that effectively converts an L-cysteine residue, an L-proline residue, and an L-serine residue to cyclo[(prolylserin)-O-yl] cysteinate. 7961166 PubMed AA0489#TRI RESID Cross-link 3. (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate RESID-alternate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate RESID-systematic cyclo[(prolylserin)-O-yl] cysteinate RESID-name MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate UniProt-feature DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 11 H 16 N 3 O 4 S 1 MassAvg 286.33 MassMono 286.086152 Origin C, P, S Source natural TermSpec C-term MOD:00915 MOD:00916 MOD:01629 PSI-MOD MOD:01438 S-[2-(pyridin-2-yl)ethyl]-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-2-yl)ethyl]-L-cysteine. 18369855 PubMed 18688235 PubMed From DeltaMass: (name misspelled "Pyridylethyl Cystenyl", and formula incorrect, N and O reversed) Formula: C10H12O2N1S1 Monoisotopic Mass Change: 208.067 Average Mass Change: 208.286 2-PEC PSI-MOD-alternate 2-vinylpyridine derivatized cysteine residue PSI-MOD-alternate Pyridylethyl PSI-MS-label Pyridylethyl Cystenyl DeltaMass-label S-(pyridin-2-ylethyl)-L-cysteine PSI-MOD-alternate S-pyridylethylation UniMod-description DiffAvg 105.14 DiffFormula C 7 H 7 N 1 DiffMono 105.057849 Formula C 10 H 12 N 2 O 1 S 1 MassAvg 208.28 MassMono 208.067034 Origin C Source artifact TermSpec none MOD:00424 PSI-MOD MOD:01439 S-[2-(pyridin-4-yl)ethyl]-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-4-yl)ethyl]-L-cysteine. 18688235 PubMed 6528972 PubMed 4-PEC PSI-MOD-alternate Pyridylethyl PSI-MS-label Pyridylethyl Cystenyl DeltaMass-label S-(pyridin-4-ylethyl)-L-cysteine PSI-MOD-alternate S-pyridylethylation UniMod-description DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none MOD:00424 PSI-MOD MOD:01440 glutamyl semialdehyde A protein modification that effectively converts a source amino acid residue to an L-glutamyl semialdehyde. 18688235 PubMed (S)-2-amino-5-oxopentanoic acid PSI-MOD-alternate L-glutamic gamma-semialdehyde PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula C 5 H 7 N 1 O 2 MassAvg 113.12 MassMono 113.047678 Origin X Source artifact TermSpec none MOD:00859 PSI-MOD MOD:01441 natural, standard, encoded residue A protein modification that inserts or replaces a residue with a natural, standard, encoded residue. 18688235 PubMed 6692818 PubMed PSI-MOD-slim Origin X Source natural TermSpec none MOD:00009 PSI-MOD MOD:01442 3-(O4'-L-tyrosyl)-L-valine A protein modification that effectively cross-links an L-valine residue and an L-tyrosine residue by an ether bond to form 3-(O4'-L-tyrosyl)-L-valine. 19321420 PubMed AA0490 RESID Cross-link 2. (2S)-2-amino-3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-3-methylbutanoic acid RESID-systematic 3-(O4'-L-tyrosyl)-L-valine RESID-name CROSSLNK 3-(O4'-tyrosyl)-valine (Val-Tyr) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 14 H 16 N 2 O 3 MassAvg 260.29 MassMono 260.116092 Origin V, Y Source natural TermSpec none MOD:00692 MOD:00919 MOD:00920 PSI-MOD MOD:01443 tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide A protein modification that effectively converts four L-glutamic acid residues and two L-histidine residues to tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide. 19321420 PubMed AA0491 RESID Cross-link 6. It is not clear whether the lipid carboxylate is a cofactor or a substrate, and its identity is not certain. It was modeled as myristic acid [JSG]. DiffAvg 350.12 DiffFormula C 14 Fe 1 H 23 Mn 1 N 0 O 3 DiffMono 350.038251 FormalCharge 1- Formula C 46 Fe 1 H 65 Mn 1 N 10 O 17 MassAvg 1140.86 MassMono 1140.326447 Origin E, E, E, E, H, H Source natural TermSpec none MOD:00438 MOD:00738 MOD:00740 MOD:00906 MOD:00909 PSI-MOD MOD:01444 L-3,3-dihydroxyoalanine (Cys) A protein modification that effectively converts an L-cysteine residue to L-3,3-dihydroxyoalanine. 11435113 PubMed 17558559 PubMed AA0492#CYS RESID (S)-2-amino-3,3-dihydroxypropanoic acid RESID-systematic 2-(dihydroxymethyl)glycine RESID-alternate 3,3-dihydroxy-L-alanine RESID-name 3,3-dihydroxyalanine RESID-alternate 3-hydroxy-L-serine RESID-alternate 3-oxoalanine hydrate RESID-alternate C(alpha)-formylglycine hydrate RESID-misnomer DiffAvg -0.06 DiffFormula C 0 H 0 N 0 O 2 S -1 DiffMono 0.017758 Formula C 3 H 5 N 1 O 3 MassAvg 103.08 MassMono 103.026943 Origin C Source natural TermSpec none MOD:00905 MOD:01448 PSI-MOD MOD:01445 L-3,3-dihydroxyoalanine (Ser) A protein modification that effectively converts an L-serine residue to L-3,3-dihydroxyoalanine. 11435113 PubMed 17558559 PubMed AA0492#SER RESID (S)-2-amino-3,3-dihydroxypropanoic acid RESID-systematic 2-(dihydroxymethyl)glycine RESID-alternate 3,3-dihydroxy-L-alanine RESID-name 3,3-dihydroxyalanine RESID-alternate 3-hydroxy-L-serine RESID-alternate 3-oxoalanine hydrate RESID-alternate C(alpha)-formylglycine hydrate RESID-misnomer DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 3 H 5 N 1 O 3 MassAvg 103.08 MassMono 103.026943 Origin S Source natural TermSpec none MOD:00916 MOD:01448 PSI-MOD MOD:01446 N-(dihydroxymethyl)-L-methionine (fMet) A protein modification that effectively converts an N-formyl-Lmethionine residue to N-(dihydroxymethyl)-L-methionine. 12595263 PubMed 9159480 PubMed AA0493 RESID (2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid RESID-systematic N-(dihydroxymethyl)-L-methionine RESID-name N-formyl-L-methionine hydrate RESID-alternate N-orthoformylmethionine RESID-alternate DiffAvg 18.02 DiffFormula C 0 H 2 N 0 O 1 S 0 DiffMono 18.010565 Formula C 6 H 12 N 1 O 3 S 1 MassAvg 178.23 MassMono 178.053789 Origin MOD:00030 Source hypothetical TermSpec N-term MOD:01450 derives_from MOD:000300 PSI-MOD MOD:01447 N-(dihydroxymethyl)-L-methionine (Met) A protein modification that effectively converts an L-methionine residue to N-(dihydroxymethyl)-L-methionine (not known as a natural, post-translational modification process). 12595263 PubMed 9159480 PubMed AA0493 RESID This entry is for the artifactual formation of N-(dihydroxymethyl)-L-methionine from methionine. For N-(dihydroxymethyl)-L-methionine derived from encoded N-formyl-L-methionine, use MOD:01446. (2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid RESID-systematic N-(dihydroxymethyl)-L-methionine RESID-name N-formyl-L-methionine hydrate RESID-alternate N-orthoformylmethionine RESID-alternate DiffAvg 46.03 DiffFormula C 1 H 2 N 0 O 2 S 0 DiffMono 46.005479 Formula C 6 H 12 N 1 O 3 S 1 MassAvg 178.23 MassMono 178.053789 Origin M Source hypothetical TermSpec N-term MOD:00913 PSI-MOD MOD:01448 L-3,3-dihydroxyoalanine A protein modification that effectively converts a source amino acid residue to L-3,3-dihydroxyoalanine. 11435113 PubMed 17558559 PubMed AA0492 RESID (S)-2-amino-3,3-dihydroxypropanoic acid RESID-systematic 2-(dihydroxymethyl)glycine RESID-alternate 3,3-dihydroxy-L-alanine RESID-name 3,3-dihydroxyalanine RESID-alternate 3-hydroxy-L-serine RESID-alternate 3-oxoalanine hydrate RESID-alternate C(alpha)-formylglycine hydrate RESID-misnomer DiffAvg none DiffFormula none DiffMono none Formula C 3 H 5 N 1 O 3 MassAvg 103.08 MassMono 103.026943 Origin X Source natural TermSpec none MOD:00859 PSI-MOD MOD:01449 L-3,3-dihydroxyoalanine (Oxoalanine) A protein modification that effectively converts an L-3-oxoalanine residue to L-3,3-dihydroxyoalanine. 11435113 PubMed 17558559 PubMed 18688235 PubMed DiffAvg 18.02 DiffFormula C 0 H 2 N 0 O 1 DiffMono 18.010565 Formula C 3 H 5 N 1 O 3 MassAvg 103.08 MassMono 103.026943 Origin MOD:01169 Source natural TermSpec none MOD:01448 derives_from MOD:011690 PSI-MOD MOD:01450 modified N-formyl-L-methionine residue A protein modification that modifies an N-formyl-L-methionine residue. 18688235 PubMed Origin MOD:00030 TermSpec N-term MOD:01157 derives_from MOD:000300 PSI-MOD MOD:01451 O-phospho-L-serine arising from O-phosphopantetheine-L-serine after neutral loss of pantetheine A protein modification that converts an L-serine residue to O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine. 17042494 PubMed 18688235 PubMed Phosphoserine is generated and detected after the facile elimination of pantetheine from the phosphopantetheine tertiary phosphodiester. See MOD:01452 for alternate origin. PSI-MOD-slim DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 3 H 6 N 1 O 5 P 1 MassAvg 167.06 MassMono 166.998359 Origin S Source artifact TermSpec none MOD:00046 MOD:00431 derives_from MOD:001590 PSI-MOD MOD:01452 O-phosphopantetheine-L-serine with neutral loss of pantetheine Covalent modification of a peptide or protein amino acid O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine. 17042494 PubMed 18688235 PubMed Phosphoserine is generated and detected after the facile elimination of pantethiene from the phosphopantethiene tertiary phosphodiester. See MOD:01451 for alternate origin. PSI-MOD-slim DiffAvg -260.35 DiffFormula C -11 H -20 N -2 O -3 P 0 S -1 DiffMono -260.119464 Formula C 3 H 6 N 1 O 5 P 1 MassAvg 167.06 MassMono 166.998359 Origin MOD:00159 Source artifact TermSpec none MOD:00046 MOD:00431 derives_from MOD:001590 PSI-MOD MOD:01453 L-glutamic acid 5-methyl ester A protein modification that effectively converts a source amino acid residue to L-glutamate 5-methyl ester. AA0072 RESID PSI-MOD-slim (2S)-2-amino-5-methoxy-5-oxopentanoic acid RESID-systematic (5)-methyl L-hydrogen glutamate RESID-alternate 2-aminopentanedioic acid 5-methyl ester RESID-alternate 5-methyl esterified L-glutamic acid PSI-MOD-alternate 5-methyl L-2-aminoglutarate RESID-alternate 5-methyl L-glutamate RESID-alternate glutamic acid 5-methyl ester RESID-alternate glutamic acid gamma-methyl ester RESID-alternate L-glutamic acid 5-methyl ester RESID-name O-methyl Glutamyl DeltaMass-label O5MeGlu PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula C 6 H 9 N 1 O 3 MassAvg 143.14 MassMono 143.058243 Origin X Source natural TermSpec none MOD:00393 MOD:00599 MOD:00713 MOD:00859 PSI-MOD MOD:01454 N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium A protein modification that effectively crosslinks an N-terminal L-proline residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium. 10833024 PubMed 11847126 PubMed 9030608 PubMed AA0494 RESID This linkage is not a Schiff-base [JSG]. (1Z,2S)-2-carboxy-1-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]pyrrolidinium RESID-systematic DNA glycosylase proline Schiff base intermediate RESID-misnomer N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium RESID-name DiffAvg 179.09 DiffFormula C 5 H 8 N 0 O 5 P 1 DiffMono 179.010386 FormalCharge 1+ Formula C 10 H 16 N 1 O 6 P 1 MassAvg 277.21 MassMono 277.070975 Origin P Source natural TermSpec N-term MOD:00750 MOD:00915 PSI-MOD MOD:01455 O-phosphorylated residue A protein modification that effectively replaces a residue hydroxyl or carboxyl hydrogen with a phosphono group (H2PO3 or 'phosphate'). 18688235 PubMed PSI-MOD-slim OPhosRes PSI-MOD-label DiffAvg 79.98 DiffFormula H 1 O 3 P 1 DiffMono 79.966331 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00696 PSI-MOD MOD:01456 N-phosphorylated residue A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with a phosphono group (H2PO3 or 'phosphate'). 18688235 PubMed PSI-MOD-slim OPhosRes PSI-MOD-label DiffAvg 79.98 DiffFormula H 1 O 3 P 1 DiffMono 79.966331 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00696 PSI-MOD MOD:01457 L-cysteine (Ser) A protein modification that effectively converts an L-serine residue to L-cysteine (not known as a natural, post-translational modification process). 1849824 PubMed 18688235 PubMed Cys(Ser) PSI-MOD-label DiffAvg -16.06 DiffFormula C 0 H 0 N 0 O 1 S -1 DiffMono -15.977156 Formula C 3 H 5 N 1 O 1 S 1 MassAvg 103.14 MassMono 103.009185 Origin C Source artifact TermSpec none MOD:00014 MOD:00749 MOD:00916 PSI-MOD MOD:01458 alpha-amino acetylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acetyl group. 1#N-term UniMod PSI-MOD-slim N2AcRes PSI-MOD-label ntermacetyl OMSSA-label DiffAvg 42.04 DiffFormula C 2 H 2 N 0 O 1 DiffMono 42.010565 Formula none MassAvg none MassMono none Origin X Source natural TermSpec N-term MOD:00408 MOD:01696 PSI-MOD MOD:01459 4x(2)H labeled alpha-dimethylamino N-terminal residue A protein modification that effectively converts an N-terminal residue to an 4x(2)H labeled alpha-dimethylamino N-terminal residue. 14670044 PubMed 199#N-term UniMod Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. PSI-MOD-slim DiMethyl-CHD2 UniMod-description Dimethyl:2H(4) PSI-MS-label mod190 OMSSA-label DiffAvg 32.06 DiffFormula C 2 (2)H 4 DiffMono 32.056407 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00552 PSI-MOD MOD:01460 alpha-amino methylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a methyl group. 18688235 PubMed PSI-MOD-slim N2MeRes PSI-MOD-label Origin X Source natural TermSpec N-term MOD:00602 PSI-MOD MOD:01461 N-methylated alanine A protein modification that effectively replaces an L-alanine alpha amino hydrogen with a methyl group. 18688235 PubMed PSI-MOD-slim Origin A Source natural TermSpec none MOD:00665 MOD:01460 PSI-MOD MOD:01462 N-methylated proline A protein modification that effectively replaces an L-proline alpha imino hydrogen with a methyl group. 18688235 PubMed PSI-MOD-slim Origin P Source natural TermSpec N-term MOD:00712 MOD:01460 PSI-MOD MOD:01463 N-methylated methionine A protein modification that effectively replaces an L-methionine alpha amino hydrogen with a methyl group. 18688235 PubMed PSI-MOD-slim Origin M Source natural TermSpec N-term MOD:00716 MOD:01460 PSI-MOD MOD:01464 protonated L-methionine (L-methioninium) residue A protein modification that effectively converts an L-methionine residue to an L-methioninium (protonated L-methionine). 18688235 PubMed PSI-MOD-slim DiffAvg 1.01 DiffFormula C 0 H 1 N 0 O 0 S 0 DiffMono 1.007276 FormalCharge 1+ Formula C 5 H 11 N 1 O 1 S 1 MassAvg 133.21 MassMono 133.055586 Origin M Source natural TermSpec N-term MOD:00913 MOD:01700 PSI-MOD MOD:01465 N,N,N-trimethyl-L-methionine (from L-methioninium) A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to an N6,N6,N6-trimethyl-L-methionine. 18688235 PubMed For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Met process (MOD:01382) accounts for both protonation and trimethylation. PSI-MOD-slim N2Me3Met PSI-MOD-label DiffAvg 42.08 DiffFormula C 3 H 6 N 0 O 0 S 0 DiffMono 42.046402 FormalCharge 1+ Formula C 8 H 17 N 1 O 1 S 1 MassAvg 175.29 MassMono 175.102537 Origin MOD:001464 Source natural TermSpec N-term MOD:01687 derives_from MOD:014640 PSI-MOD MOD:01466 menadione quinone derivative - site C modification from UniMod Chemical derivative 15939799 PubMed 302#K UniMod Menadione UniMod-interim Menadione quinone derivative UniMod-description DiffAvg 170.17 DiffFormula C 11 H 6 O 2 DiffMono 170.036779 Formula C 14 H 11 N 1 O 3 S 1 MassAvg 273.31 MassMono 273.045964 Origin C Source artifact TermSpec none MOD:00621 MOD:00905 PSI-MOD MOD:01467 menadione quinone derivative - site K modification from UniMod Chemical derivative 15939799 PubMed 302#K UniMod Menadione UniMod-interim Menadione quinone derivative UniMod-description DiffAvg 170.17 DiffFormula C 11 H 6 O 2 DiffMono 170.036779 Formula C 17 H 18 N 2 O 3 MassAvg 298.34 MassMono 298.131742 Origin K Source artifact TermSpec none MOD:00621 MOD:00912 PSI-MOD MOD:01468 L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Cys) A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process). 14235557 PubMed 2211698 PubMed 8052647 PubMed 9036855 PubMed AA0248#CYS RESID 415 UniMod This entry is for the artifactual formation of L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00253. 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide RESID-alternate bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-selenocysteinyl-Se-molybdenum RESID-systematic formate dehydrogenase selenocysteine molybdenum cofactor RESID-alternate L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) UniMod-description L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) RESID-name molybdopterin-se UniMod-interim MolybdopterinGD+Delta:S(-1)Se(1) PSI-MS-label DiffAvg 1618.93 DiffFormula C 40 H 47 Mo 1 N 20 O 26 P 4 S 3 Se 1 DiffMono 1620.930226 Formula C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1 MassAvg 1722.07 MassMono 1723.939410 Origin C Source artifact TermSpec none MOD:00744 MOD:00905 PSI-MOD MOD:01469 L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Cys) A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process). 11372198 PubMed 12220497 PubMed AA0376#CYS RESID This entry is for the artifactual formation of L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00381. DiffAvg 1738.88 DiffFormula C 40 H 47 N 20 O 26 P 4 S 4 Se 1 W 1 DiffMono 1738.947820 Formula C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1 MassAvg 1842.02 MassMono 1841.957004 Origin C Source artifact TermSpec none MOD:00746 MOD:00748 MOD:00905 PSI-MOD MOD:01470 (E)-dehydrobutyrine (Thr) A protein modification that effectively converts an L-threonine residue to (E)-dehydrobutyrine. 0 DeltaMass 1547888 PubMed 20805503 PubMed 3769923 PubMed AA0547 RESID PSI-MOD-slim (2E)-2-aminobut-2-enoic acid RESID-systematic (E)-2-amino-2-butenoic acid RESID-alternate (E)-2-aminobutenoic acid RESID-alternate (E)-dehydrobutyrine RESID-name (E)dHAbu PSI-MOD-label 2,3-didehydrobutyrine RESID-alternate 3-methyldehydroalanine RESID-alternate alpha,beta-dehydroaminobutyric acid RESID-alternate anhydrothreonine RESID-alternate Dehydrated UniMod-interim Dehydration UniMod-description Dehydroamino butyric acid DeltaMass-label Dhb RESID-alternate methyl-dehydroalanine RESID-alternate MOD_RES (E)-2,3-didehydrobutyrine UniProt-feature DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 4 H 5 N 1 O 1 MassAvg 83.09 MassMono 83.037114 Origin T Source natural TermSpec none MOD:00190 PSI-MOD MOD:01471 (Z)-dehydrobutyrine (Thr) A protein modification that effectively converts an L-threonine residue to (Z)-dehydrobutyrine. 0 DeltaMass 1547888 PubMed 3769923 PubMed AA0182 RESID PSI-MOD-slim (2Z)-2-aminobut-2-enoic acid RESID-systematic (Z)-2-amino-2-butenoic acid RESID-alternate (Z)-2-aminobutenoic acid RESID-alternate (Z)-dehydrobutyrine RESID-name (Z)dHAbu PSI-MOD-label 2,3-didehydrobutyrine RESID-alternate 3-methyldehydroalanine RESID-alternate alpha,beta-dehydroaminobutyric acid RESID-alternate anhydrothreonine RESID-alternate Dehydrated UniMod-interim Dehydration UniMod-description Dehydroamino butyric acid DeltaMass-label Dhb RESID-alternate methyl-dehydroalanine RESID-alternate MOD_RES (Z)-2,3-didehydrobutyrine UniProt-feature DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 4 H 5 N 1 O 1 MassAvg 83.09 MassMono 83.037114 Origin T Source natural TermSpec none MOD:00190 PSI-MOD MOD:01472 reduced residue A protein modification that effectively either adds neutral hydrogen atoms (proton and electron), or removes oxygen atoms from a residue with or without the addition of hydrogen atoms. 18688235 PubMed PSI-MOD-slim RedRes PSI-MOD-label MOD:01156 PSI-MOD MOD:01473 hydrogenated residue A protein modification that effectively adds neutral hydrogen atoms (proton and electron) to a residue. 18688235 PubMed PSI-MOD-slim HRes PSI-MOD-label MOD:01472 PSI-MOD MOD:01474 O-[S-(carboxymethyl)phosphopantetheine]-L-serine A protein modification that effectively converts an L-serine residue to O-[S-(carboxymethyl)phosphopantetheine]-L-serine. 18688235 PubMed This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetic acid [JSG]. DiffAvg 398.37 DiffFormula C 13 H 23 N 2 O 8 P 1 S 1 DiffMono 398.091273 Formula C 16 H 28 N 3 O 10 P 1 S 1 MassAvg 485.44 MassMono 485.123302 Origin S Source artifact TermSpec none MOD:00399 MOD:00861 MOD:00916 derives_from MOD:001590 PSI-MOD MOD:01475 O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine A protein modification that effectively converts an L-serine residue to O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine. 18688235 PubMed This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetamide [JSG]. DiffAvg 397.38 DiffFormula C 13 H 24 N 3 O 7 P 1 S 1 DiffMono 397.107258 Formula C 16 H 29 N 4 O 9 P 1 S 1 MassAvg 484.46 MassMono 484.139286 Origin S Source artifact TermSpec none MOD:00397 MOD:00861 MOD:00916 derives_from MOD:001590 PSI-MOD MOD:01476 2'-fluoro-L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to an 2'-fluoro-L-fluorophenylalanine. 18688235 PubMed 8172898 PubMed 2-fluorophenylalanine PSI-MOD-alternate o-fluorophenylalanine PSI-MOD-alternate ortho-fluorophenylalanine PSI-MOD-alternate DiffAvg 17.99 DiffFormula C 0 F 1 H -1 N 0 O 0 DiffMono 17.990578 Formula C 9 F 1 H 8 N 1 O 1 MassAvg 165.17 MassMono 165.058992 Origin F Source artifact TermSpec none MOD:01227 PSI-MOD MOD:01477 3'-fluoro-L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to an 3'-fluoro-L-fluorophenylalanine. 18688235 PubMed 8172898 PubMed 3-fluorophenylalanine PSI-MOD-alternate m-fluorophenylalanine PSI-MOD-alternate meta-fluorophenylalanine PSI-MOD-alternate DiffAvg 17.99 DiffFormula C 0 F 1 H -1 N 0 O 0 DiffMono 17.990578 Formula C 9 F 1 H 8 N 1 O 1 MassAvg 165.17 MassMono 165.058992 Origin F Source artifact TermSpec none MOD:01227 PSI-MOD MOD:01478 4'-fluoro-L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue into an 4'-fluoro-L-fluorophenylalanine. 18688235 PubMed 8172898 PubMed 4-fluorophenylalanine PSI-MOD-alternate p-fluorophenylalanine PSI-MOD-alternate para-fluorophenylalanine PSI-MOD-alternate rho-fluorophenylalanine PSI-MOD-alternate DiffAvg 17.99 DiffFormula C 0 F 1 H -1 N 0 O 0 DiffMono 17.990578 Formula C 9 F 1 H 8 N 1 O 1 MassAvg 165.17 MassMono 165.058992 Origin F Source artifact TermSpec none MOD:01227 PSI-MOD MOD:01479 4'-fluoro-L-tryptophan A protein modification that effectively converts an L-tryptophan residue into an 4'-fluoro-L-tryptophan. 18688235 PubMed 8172898 PubMed 4-fluorotryptophan PSI-MOD-alternate DiffAvg 17.99 DiffFormula F 1 H -1 DiffMono 17.990578 Formula C 11 F 1 H 9 N 2 O 1 MassAvg 204.20 MassMono 204.069891 Origin W Source artifact TermSpec none MOD:01226 PSI-MOD MOD:01480 5'-fluoro-L-tryptophan A protein modification that effectively converts an L-tryptophan residue into an 5'-fluoro-L-tryptophan. 18688235 PubMed 8172898 PubMed 5-fluorotryptophan PSI-MOD-alternate DiffAvg 17.99 DiffFormula F 1 H -1 DiffMono 17.990578 Formula C 11 F 1 H 9 N 2 O 1 MassAvg 204.20 MassMono 204.069891 Origin W Source artifact TermSpec none MOD:01226 PSI-MOD MOD:01481 6'-fluoro-L-tryptophan A protein modification that effectively converts an L-tryptophan residue into an 6'-fluoro-L-tryptophan. 18688235 PubMed 8172898 PubMed 6-fluorotryptophan PSI-MOD-alternate DiffAvg 17.99 DiffFormula F 1 H -1 DiffMono 17.990578 Formula C 11 F 1 H 9 N 2 O 1 MassAvg 204.20 MassMono 204.069891 Origin W Source artifact TermSpec none MOD:01226 PSI-MOD MOD:01482 calcium containing modified residue A protein modification that effectively substitutes a calcium atom or a cluster containing calcium for hydrogen atoms, or that coordinates a calcium ion. 18688235 PubMed PSI-MOD-slim CaRes PSI-MOD-label MOD:00698 PSI-MOD MOD:01483 O-formylated residue A protein modification that effectively replaces a residue hydroxyl group with a formyloxy group. 18688235 PubMed OFoRes PSI-MOD-label DiffAvg 28.01 DiffFormula C 1 O 1 DiffMono 27.994915 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00493 MOD:00671 PSI-MOD MOD:01484 N6-(L-isoglutamyl)-L-lysine (Glu) A protein modification that effectively crosslinks an L-glutamic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine and the release of water. 21863 ChEBI 19015515 PubMed AA0124#GLU RESID Cross-link 2. This cross-link is usually made by glutamine and releases ammonia, rather than glutamic acid and requiring the consumption of ATP. (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid RESID-systematic 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid RESID-alternate 5-glutamyl N6-lysine RESID-alternate N alpha -(gamma-Glutamyl)-lysine DeltaMass-label N(epsilon)-(gamma-glutamyl)lysine RESID-alternate N6-(L-isoglutamyl)-L-lysine RESID-name DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 11 H 17 N 3 O 3 MassAvg 239.27 MassMono 239.126991 Origin K, E Source natural TermSpec none MOD:00906 MOD:00954 MOD:01630 PSI-MOD MOD:01485 iTRAQ4plex-114 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. 532 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 114 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ114 UniMod-interim iTRAQ4plex114 PSI-MS-label DiffAvg 144.11 DiffFormula (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono 144.105919 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01430 MOD:01516 MOD:01518 PSI-MOD MOD:01486 iTRAQ4plex-114 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. 532#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 114 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ114 UniMod-interim iTRAQ114nterm OMSSA-label iTRAQ4plex114 PSI-MS-label DiffAvg 144.11 DiffFormula (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono 144.105919 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01485 MOD:01711 PSI-MOD MOD:01487 iTRAQ4plex-114 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. 532#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 114 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ114 UniMod-interim iTRAQ114K OMSSA-label iTRAQ4plex114 PSI-MS-label DiffAvg 144.11 DiffFormula (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono 144.105919 Formula (12)C 11 (13)C 2 H 24 N 4 (16)O 1 (18)O 1 MassAvg 272.20 MassMono 272.200882 Origin K Source artifact TermSpec none MOD:01485 MOD:01709 MOD:01875 PSI-MOD MOD:01488 iTRAQ4plex-114 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. 532#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 114 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ114 UniMod-interim iTRAQ114Y OMSSA-label iTRAQ4plex114 PSI-MS-label DiffAvg 144.11 DiffFormula (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono 144.105919 Formula (12)C 14 (13)C 2 H 21 N 3 (16)O 2 (18)O 1 MassAvg 307.17 MassMono 307.169248 Origin Y Source artifact TermSpec none MOD:00919 MOD:01485 MOD:01713 PSI-MOD MOD:01489 iTRAQ4plex-114 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex114 PSI-MS-label DiffAvg 144.11 DiffFormula (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono 144.105919 Formula (12)C 11 (13)C 2 H 19 N 5 O 1 (18)O 1 MassAvg 281.16 MassMono 281.164831 Origin H Source artifact TermSpec none MOD:00909 MOD:01485 MOD:01709 PSI-MOD MOD:01490 iTRAQ4plex-114 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex114 PSI-MS-label DiffAvg 144.11 DiffFormula (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono 144.105919 Formula (12)C 8 (13)C 2 H 17 N 3 O 2 (18)O 1 MassAvg 231.14 MassMono 231.137947 Origin S Source artifact TermSpec none MOD:00916 MOD:01485 MOD:01713 PSI-MOD MOD:01491 iTRAQ4plex-114 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex114 PSI-MS-label DiffAvg 144.11 DiffFormula (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono 144.105919 Formula (12)C 9 (13)C 2 H 19 N 3 O 2 (18)O 1 MassAvg 245.15 MassMono 245.153598 Origin T Source artifact TermSpec none MOD:00917 MOD:01485 MOD:01713 PSI-MOD MOD:01492 iTRAQ4plex-115 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. 533 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ115 UniMod-interim iTRAQ4plex115 PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono 144.099599 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01430 MOD:01516 MOD:01518 PSI-MOD MOD:01493 iTRAQ4plex-115 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. 533#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ115 UniMod-interim iTRAQ115nterm OMSSA-label iTRAQ4plex115 PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono 144.099599 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01492 MOD:01711 PSI-MOD MOD:01494 iTRAQ4plex-115 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. 533#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ115 UniMod-interim iTRAQ115K OMSSA-label iTRAQ4plex115 PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono 144.099599 Formula (12)C 12 (13)C 1 H 24 (14)N 3 (15)N 1 (16)O 1 (18)O 1 MassAvg 272.19 MassMono 272.194562 Origin K Source artifact TermSpec none MOD:01492 MOD:01709 MOD:01875 PSI-MOD MOD:01495 iTRAQ4plex-115 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. 533#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ115 UniMod-interim iTRAQ115Y OMSSA-label iTRAQ4plex115 PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono 144.099599 Formula (12)C 15 (13)C 1 H 21 (14)N 2 (15)N 1 (16)O 2 (18)O 1 MassAvg 307.16 MassMono 307.162928 Origin Y Source artifact TermSpec none MOD:00919 MOD:01492 MOD:01713 PSI-MOD MOD:01496 iTRAQ4plex-115 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex115 PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono 144.099599 Formula (12)C 12 (13)C 1 H 19 (14)N 4 (15)N 1 (16)O 1 (18)O 1 MassAvg 281.16 MassMono 281.158511 Origin H Source artifact TermSpec none MOD:00909 MOD:01492 MOD:01709 PSI-MOD MOD:01497 iTRAQ4plex-115 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex115 PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono 144.099599 Formula (12)C 9 (13)C 1 H 17 N 1 (14)N 1 (15)N 1 (16)O 2 (18)O 1 MassAvg 231.13 MassMono 231.131628 Origin S Source artifact TermSpec none MOD:00916 MOD:01492 MOD:01713 PSI-MOD MOD:01498 iTRAQ4plex-115 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex115 PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono 144.099599 Formula (12)C 10 (13)C 1 H 19 (14)N 2 (15)N 1 (16)O 2 (18)O 1 MassAvg 245.15 MassMono 245.147278 Origin T Source artifact TermSpec none MOD:00917 MOD:01492 MOD:01713 PSI-MOD MOD:01499 iTRAQ4plex-116 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. 214 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ UniMod-interim iTRAQ4plex PSI-MS-label Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01517 MOD:01518 PSI-MOD MOD:01500 iTRAQ4plex-116 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. 214#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ UniMod-interim iTRAQ116nterm OMSSA-label iTRAQ4plex PSI-MS-label Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01499 MOD:01711 PSI-MOD MOD:01501 iTRAQ4plex-116 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. 214#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ UniMod-interim iTRAQ116K OMSSA-label iTRAQ4plex PSI-MS-label Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1 MassAvg 272.20 MassMono 272.197025 Origin K Source artifact TermSpec none MOD:01499 MOD:01709 MOD:01875 PSI-MOD MOD:01502 iTRAQ4plex-116 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. 214#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ UniMod-interim iTRAQ116Y OMSSA-label iTRAQ4plex PSI-MS-label Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1 MassAvg 307.17 MassMono 307.165391 Origin Y Source artifact TermSpec none MOD:00919 MOD:01499 MOD:01713 PSI-MOD MOD:01503 iTRAQ4plex-116 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 10 (13)C 3 H 19 N 3 (14)N 1 (15)N 1 (16)O 2 MassAvg 281.16 MassMono 281.160974 Origin H Source artifact TermSpec none MOD:00909 MOD:01499 MOD:01709 PSI-MOD MOD:01504 iTRAQ4plex-116 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3 MassAvg 231.13 MassMono 231.134091 Origin S Source artifact TermSpec none MOD:00916 MOD:01499 MOD:01713 PSI-MOD MOD:01505 iTRAQ4plex-116 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3 MassAvg 245.15 MassMono 245.149741 Origin T Source artifact TermSpec none MOD:00917 MOD:01499 MOD:01713 PSI-MOD MOD:01506 iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. 214 UniMod 889 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate iTRAQ UniMod-interim iTRAQ4plex PSI-MS-label mTRAQ heavy UniMod-description Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01517 MOD:01518 MOD:01863 PSI-MOD MOD:01507 iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. 214#N-term UniMod 889N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate iTRAQ UniMod-interim iTRAQ117nterm OMSSA-label iTRAQ4plex PSI-MS-label mTRAQ heavy UniMod-description mTRAQ heavy on nterm OMSSA-label Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01506 MOD:01711 PSI-MOD MOD:01508 iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. 214#K UniMod 889#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate iTRAQ UniMod-interim iTRAQ117K OMSSA-label iTRAQ4plex PSI-MS-label mTRAQ heavy UniMod-description mTRAQ heavy on K OMSSA-label Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1 MassAvg 272.20 MassMono 272.197025 Origin K Source artifact TermSpec none MOD:01506 MOD:01709 MOD:01875 PSI-MOD MOD:01509 iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. 214#Y UniMod 889#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate iTRAQ UniMod-interim iTRAQ117Y OMSSA-label iTRAQ4plex PSI-MS-label mTRAQ heavy UniMod-description mTRAQ heavy on Y OMSSA-label Representative mass and accurate mass for 116 & 117 UniMod-description DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1 MassAvg 307.17 MassMono 307.165391 Origin Y Source artifact TermSpec none MOD:00919 MOD:01506 MOD:01713 PSI-MOD MOD:01510 iTRAQ4plex-117 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 10 (13)C 3 H 19 (14)N 4 (15)N 1 (16)O 2 MassAvg 281.16 MassMono 281.160974 Origin H Source artifact TermSpec none MOD:00909 MOD:01506 MOD:01709 PSI-MOD MOD:01511 iTRAQ4plex-117 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3 MassAvg 231.13 MassMono 231.134091 Origin S Source artifact TermSpec none MOD:00916 MOD:01506 MOD:01713 PSI-MOD MOD:01512 iTRAQ4plex-117 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate iTRAQ4plex PSI-MS-label DiffAvg 144.10 DiffFormula (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono 144.102062 Formula (12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3 MassAvg 245.15 MassMono 245.149741 Origin T Source artifact TermSpec none MOD:00917 MOD:01506 MOD:01713 PSI-MOD MOD:01513 modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.1 Da. 18688235 PubMed PSI-MOD-slim MOD:00538 PSI-MOD MOD:01514 modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.01 Da. 18688235 PubMed PSI-MOD-slim MOD:01513 PSI-MOD MOD:01515 modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.000001 Da. 18688235 PubMed PSI-MOD-slim MOD:01514 PSI-MOD MOD:01516 modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. Modifications that have monoisotopic mass differences from their respective origins of 144.099-144.106 Da. 18688235 PubMed PSI-MOD-slim MOD:01514 PSI-MOD MOD:01517 modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da Modifications that have monoisotopic mass differences from their respective origins of 144.102062 Da. 18688235 PubMed PSI-MOD-slim MOD:01515 MOD:01516 PSI-MOD MOD:01518 iTRAQ4plex reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. 214 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 MOD:01705 PSI-MOD MOD:01519 reporter fragment A distinct molecular entity produced from a protein or a protein modification as the result of a fragmentation process. 18688235 PubMed The reporter fragment is either itself a modification consisting of atoms derived from the original amino acid residues, or its detection can be taken as evidence that particular modified residues had been present. PSI-MOD-slim MOD:01156 PSI-MOD MOD:01520 modification reporter fragment A distinct molecular entity produced as the result of a fragmentation process performed on a particular modified residue. 18688235 PubMed PSI-MOD-slim MOD:01519 PSI-MOD MOD:01521 iTRAQ4plex reporter fragment A protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex reagent derivatized residue. 18688235 PubMed PSI-MOD-slim MOD:01520 PSI-MOD MOD:01522 iTRAQ4plex-114 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 114 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 5 (13)C 1 H 13 (14)N 2 MassAvg 114.11 MassMono 114.110680 Origin X Source artifact TermSpec none MOD:01521 derives_from MOD:014850 PSI-MOD MOD:01523 iTRAQ4plex-115 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 115 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1 MassAvg 115.11 MassMono 115.107715 Origin X Source artifact TermSpec none MOD:01521 derives_from MOD:014920 PSI-MOD MOD:01524 iTRAQ4plex-116 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 116 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1 MassAvg 116.11 MassMono 116.111069 Origin X Source artifact TermSpec none MOD:01521 derives_from MOD:014990 PSI-MOD MOD:01525 iTRAQ4plex-117, mTRAQ heavy, reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 117 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1 MassAvg 117.11 MassMono 117.114424 Origin X Source artifact TermSpec none MOD:01521 MOD:01870 derives_from MOD:015060 PSI-MOD MOD:01526 iTRAQ8plex reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. 730 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 MOD:01705 PSI-MOD MOD:01527 residue reporter fragment A distinct molecular entity produced from a particular amino acid residue as the result of a fragmentation process. 18688235 PubMed PSI-MOD-slim MOD:01519 PSI-MOD MOD:01528 iTRAQ8plex-113 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. 730 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01526 MOD:01591 PSI-MOD MOD:01529 iTRAQ8plex-113 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. 730#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01528 MOD:01712 PSI-MOD MOD:01530 iTRAQ8plex-113 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. 730#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 MassAvg 432.30 MassMono 432.300322 Origin K Source artifact TermSpec none MOD:01528 MOD:01710 MOD:01875 PSI-MOD MOD:01531 iTRAQ8plex-113 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. 730#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 MassAvg 467.27 MassMono 467.268688 Origin Y Source artifact TermSpec none MOD:00919 MOD:01528 MOD:01714 PSI-MOD MOD:01532 iTRAQ8plex-113 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 MassAvg 441.26 MassMono 441.264271 Origin H Source artifact TermSpec none MOD:00909 MOD:01528 MOD:01710 PSI-MOD MOD:01533 iTRAQ8plex-113 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 MassAvg 391.24 MassMono 391.237388 Origin S Source artifact TermSpec none MOD:00916 MOD:01528 MOD:01714 PSI-MOD MOD:01534 iTRAQ8plex-113 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 MassAvg 405.25 MassMono 405.253038 Origin T Source artifact TermSpec none MOD:00917 MOD:01528 MOD:01714 PSI-MOD MOD:01535 iTRAQ8plex-114 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. 730 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01526 MOD:01591 PSI-MOD MOD:01536 iTRAQ8plex-114 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. 730#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01535 MOD:01712 PSI-MOD MOD:01537 iTRAQ8plex-114 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. 730#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 MassAvg 432.30 MassMono 432.300322 Origin K Source artifact TermSpec none MOD:01535 MOD:01710 MOD:01875 PSI-MOD MOD:01538 iTRAQ8plex-114 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. 730#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 MassAvg 467.27 MassMono 467.268688 Origin Y Source artifact TermSpec none MOD:00919 MOD:01535 MOD:01714 PSI-MOD MOD:01539 iTRAQ8plex-114 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 MassAvg 441.26 MassMono 441.264271 Origin H Source artifact TermSpec none MOD:00909 MOD:01535 MOD:01710 PSI-MOD MOD:01540 iTRAQ8plex-114 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 MassAvg 391.24 MassMono 391.237388 Origin S Source artifact TermSpec none MOD:00916 MOD:01535 MOD:01714 PSI-MOD MOD:01541 iTRAQ8plex-114 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 MassAvg 405.25 MassMono 405.253038 Origin T Source artifact TermSpec none MOD:00917 MOD:01535 MOD:01714 PSI-MOD MOD:01542 iTRAQ8plex-115 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. 731 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01526 MOD:01584 PSI-MOD MOD:01543 iTRAQ8plex-115 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. 731#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01542 MOD:01712 PSI-MOD MOD:01544 iTRAQ8plex-115 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. 731#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 MassAvg 432.29 MassMono 432.294002 Origin K Source artifact TermSpec none MOD:01542 MOD:01710 MOD:01875 PSI-MOD MOD:01545 iTRAQ8plex-115 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. 731#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 MassAvg 467.26 MassMono 467.262368 Origin Y Source artifact TermSpec none MOD:00919 MOD:01542 MOD:01714 PSI-MOD MOD:01546 iTRAQ8plex-115 reporter+balance reagent N'-derivatized histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 MassAvg 441.26 MassMono 441.257951 Origin H Source artifact TermSpec none MOD:00909 MOD:01542 MOD:01710 PSI-MOD MOD:01547 iTRAQ8plex-115 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 MassAvg 391.23 MassMono 391.231068 Origin S Source artifact TermSpec none MOD:00916 MOD:01542 MOD:01714 PSI-MOD MOD:01548 iTRAQ8plex-115 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 MassAvg 405.25 MassMono 405.246718 Origin T Source artifact TermSpec none MOD:00917 MOD:01542 MOD:01714 PSI-MOD MOD:01549 iTRAQ8plex-116 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. 730 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01526 MOD:01591 PSI-MOD MOD:01550 iTRAQ8plex-116 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. 730#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01549 MOD:01712 PSI-MOD MOD:01551 iTRAQ8plex-116 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. 730#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 MassAvg 432.30 MassMono 432.300322 Origin K Source artifact TermSpec none MOD:01549 MOD:01710 MOD:01875 PSI-MOD MOD:01552 iTRAQ8plex-116 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. 730#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 MassAvg 467.27 MassMono 467.268688 Origin Y Source artifact TermSpec none MOD:00919 MOD:01549 MOD:01714 PSI-MOD MOD:01553 iTRAQ8plex-116 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 MassAvg 441.26 MassMono 441.264271 Origin H Source artifact TermSpec none MOD:00909 MOD:01549 MOD:01710 PSI-MOD MOD:01554 iTRAQ8plex-116 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 MassAvg 391.24 MassMono 391.237388 Origin S Source artifact TermSpec none MOD:00916 MOD:01549 MOD:01714 PSI-MOD MOD:01555 iTRAQ8plex-116 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 MassAvg 405.25 MassMono 405.253038 Origin T Source artifact TermSpec none MOD:00917 MOD:01549 MOD:01714 PSI-MOD MOD:01556 iTRAQ8plex-117 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. 730 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01526 MOD:01591 PSI-MOD MOD:01557 iTRAQ8plex-117 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. 730#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01556 MOD:01712 PSI-MOD MOD:01558 iTRAQ8plex-117 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. 730#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 MassAvg 432.30 MassMono 432.300322 Origin K Source artifact TermSpec none MOD:01556 MOD:01710 MOD:01875 PSI-MOD MOD:01559 iTRAQ8plex-117 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. 730#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex UniMod-interim iTRAQ8plex:13C(7)15N(1) UniMod-alternate Representative mass and accurate mass for 113, 114, 116 & 117 UniMod-description DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 MassAvg 467.27 MassMono 467.268688 Origin Y Source artifact TermSpec none MOD:00919 MOD:01556 MOD:01714 PSI-MOD MOD:01560 iTRAQ8plex-117 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 MassAvg 441.26 MassMono 441.264271 Origin H Source artifact TermSpec none MOD:00909 MOD:01556 MOD:01710 PSI-MOD MOD:01561 iTRAQ8plex-117 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 MassAvg 391.24 MassMono 391.237388 Origin S Source artifact TermSpec none MOD:00916 MOD:01556 MOD:01714 PSI-MOD MOD:01562 iTRAQ8plex-117 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.21 DiffFormula (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono 304.205359 Formula (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 MassAvg 405.25 MassMono 405.253038 Origin T Source artifact TermSpec none MOD:00917 MOD:01556 MOD:01714 PSI-MOD MOD:01563 iTRAQ8plex-118 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. 731 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01526 MOD:01584 PSI-MOD MOD:01564 iTRAQ8plex-118 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. 731#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01563 MOD:01712 PSI-MOD MOD:01565 iTRAQ8plex-118 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. 731#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 MassAvg 432.29 MassMono 432.294002 Origin K Source artifact TermSpec none MOD:01563 MOD:01710 MOD:01875 PSI-MOD MOD:01566 iTRAQ8plex-118 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. 731#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 MassAvg 467.26 MassMono 467.262368 Origin Y Source artifact TermSpec none MOD:00919 MOD:01563 MOD:01714 PSI-MOD MOD:01567 iTRAQ8plex-118 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 MassAvg 441.26 MassMono 441.257951 Origin H Source artifact TermSpec none MOD:00909 MOD:01563 MOD:01710 PSI-MOD MOD:01568 iTRAQ8plex-118 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 MassAvg 391.23 MassMono 391.231068 Origin S Source artifact TermSpec none MOD:00916 MOD:01563 MOD:01714 PSI-MOD MOD:01569 iTRAQ8plex-118 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 MassAvg 405.25 MassMono 405.246718 Origin T Source artifact TermSpec none MOD:00917 MOD:01563 MOD:01714 PSI-MOD MOD:01570 iTRAQ8plex-119 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. 731 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01526 MOD:01584 PSI-MOD MOD:01571 iTRAQ8plex-119 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. 731#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01570 MOD:01712 PSI-MOD MOD:01572 iTRAQ8plex-119 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. 731#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 MassAvg 432.29 MassMono 432.294002 Origin K Source artifact TermSpec none MOD:01570 MOD:01710 MOD:01875 PSI-MOD MOD:01573 iTRAQ8plex-119 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. 731#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 MassAvg 467.26 MassMono 467.262368 Origin Y Source artifact TermSpec none MOD:00919 MOD:01570 MOD:01714 PSI-MOD MOD:01574 iTRAQ8plex-119 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 MassAvg 441.26 MassMono 441.257951 Origin H Source artifact TermSpec none MOD:00909 MOD:01570 MOD:01710 PSI-MOD MOD:01575 iTRAQ8plex-119 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 MassAvg 391.23 MassMono 391.231068 Origin S Source artifact TermSpec none MOD:00916 MOD:01570 MOD:01714 PSI-MOD MOD:01576 iTRAQ8plex-119 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 MassAvg 405.25 MassMono 405.246718 Origin T Source artifact TermSpec none MOD:00917 MOD:01570 MOD:01714 PSI-MOD MOD:01577 iTRAQ8plex-121 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. 731 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01526 MOD:01584 PSI-MOD MOD:01578 iTRAQ8plex-121 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. 731#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01577 MOD:01712 PSI-MOD MOD:01579 iTRAQ8plex-121 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. 731#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 MassAvg 432.29 MassMono 432.294002 Origin K Source artifact TermSpec none MOD:01577 MOD:01710 MOD:01875 PSI-MOD MOD:01580 iTRAQ8plex-121 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. 731#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Accurate mass for 115, 118, 119 & 121 UniMod-description Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry UniMod-alternate iTRAQ8plex:13C(6)15N(2) UniMod-interim DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 MassAvg 467.26 MassMono 467.262368 Origin Y Source artifact TermSpec none MOD:00919 MOD:01577 MOD:01714 PSI-MOD MOD:01581 iTRAQ8plex-121 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 MassAvg 441.26 MassMono 441.257951 Origin H Source artifact TermSpec none MOD:00909 MOD:01577 MOD:01710 PSI-MOD MOD:01582 iTRAQ8plex-121 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 MassAvg 391.23 MassMono 391.231068 Origin S Source artifact TermSpec none MOD:00916 MOD:01577 MOD:01714 PSI-MOD MOD:01583 iTRAQ8plex-121 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg 304.20 DiffFormula (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono 304.199039 Formula (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 MassAvg 405.25 MassMono 405.246718 Origin T Source artifact TermSpec none MOD:00917 MOD:01577 MOD:01714 PSI-MOD MOD:01584 modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da Modifications that have monoisotopic mass differences from their respective origins of 304.199039 Da. 18688235 PubMed PSI-MOD-slim MOD:01515 MOD:01592 PSI-MOD MOD:01585 O-glycyl-L-serine A protein modification that effectively crosslinks an L-serine residue and a glycine residue by an ester bond to form O-glycyl-L-serine. 17502423 PubMed AA0495 RESID Cross-link 2. (2S)-2-amino-3-[(aminoacetyl)oxy]propanoic acid RESID-systematic O-(glycyl)-L-serine RESID-name O3-(aminoacetyl)serine RESID-alternate serine glycinate ester RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 5 H 7 N 2 O 3 MassAvg 143.12 MassMono 143.045667 Origin G, S Source natural TermSpec C-term MOD:00885 MOD:00908 MOD:00916 MOD:00954 PSI-MOD MOD:01586 O-glycyl-L-threonine A protein modification that effectively crosslinks an L-threonine residue and a glycine residue by an ester bond to form O-glycyl-L-threonine. 17502423 PubMed AA0496 RESID Cross-link 2. (2S,3R)-2-amino-3-[(aminoacetyl)oxy]butanoic acid RESID-systematic O-(glycyl)-L-threonine RESID-name O3-(2-aminoacetyl)threonine RESID-alternate threonine glycinate ester RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 9 N 2 O 3 MassAvg 157.15 MassMono 157.061317 Origin G, T Source natural TermSpec C-term MOD:00885 MOD:00908 MOD:00917 MOD:00954 PSI-MOD MOD:01587 O-(2-aminoethylphosphoryl)-L-serine A protein modification that effectively converts an L-serine residue to O-(2-aminoethylphosphoryl)-L-serine. 15249686 PubMed 16825186 PubMed 16949362 PubMed AA0497 RESID (2S)-2-amino-3-([(2-aminoethoxy)(hydroxy)phosphoryl]oxy)propanoic acid RESID-systematic MOD_RES O-(2-aminoethylphosphoryl)serine UniProt-feature O-(2-aminoethylphosphoryl)-L-serine RESID-name O3-(2-aminoethylphosphoryl)-L-serine RESID-alternate O3-(phosphoethanolamine)-L-serine RESID-alternate serine ethanolamine phosphate RESID-alternate serine ethanolamine phosphodiester RESID-alternate DiffAvg 123.05 DiffFormula C 2 H 6 N 1 O 3 P 1 DiffMono 123.008530 Formula C 5 H 11 N 2 O 5 P 1 MassAvg 210.13 MassMono 210.040558 Origin S Source natural TermSpec none MOD:00861 MOD:00916 PSI-MOD MOD:01588 O-cholinephosphoryl-L-serine A protein modification that effectively converts an L-serine residue to O-cholinephosphoryl-L-serine. 15249686 PubMed 16825186 PubMed 16949362 PubMed AA0498 RESID 2-[([(2S)-2-amino-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanaminium RESID-systematic 2-[([(2S)-2-azanyl-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanazanium RESID-alternate MOD_RES O-(2-cholinephosphoryl)serine UniProt-feature O-cholinephosphoryl-L-serine RESID-name O3-[(2-[trimethylammonio]ethyl)phosphoryl]-L-serine RESID-alternate O3-phosphocholine-L-serine RESID-alternate serine choline phosphate RESID-alternate serine choline phosphodiester RESID-alternate DiffAvg 166.14 DiffFormula C 5 H 13 N 1 O 3 P 1 DiffMono 166.062756 FormalCharge 1+ Formula C 8 H 18 N 2 O 5 P 1 MassAvg 253.21 MassMono 253.094785 Origin S Source natural TermSpec none MOD:00861 MOD:00916 PSI-MOD MOD:01589 O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine. 15249686 PubMed 16949362 PubMed AA0499 RESID (2S)-2-amino-3-[(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)oxy]propanoic acid RESID-systematic DADDGlc RESID-alternate O-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine RESID-alternate O-(2,4-diacetamido-2,4-dideoxy-D-glucosyl)-L-serine RESID-name O-[2,4-bis(acetylamino)]glucosyl-L-serine RESID-alternate O-seryl-beta-2,4-bis(acetylamino)glucoside RESID-alternate O3-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine RESID-alternate DiffAvg 244.25 DiffFormula C 10 H 16 N 2 O 5 DiffMono 244.105922 Formula C 13 H 21 N 3 O 7 MassAvg 331.33 MassMono 331.137950 Origin S Source natural TermSpec none MOD:00002 PSI-MOD MOD:01590 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan. 52950 ChEBI 18323630 PubMed AA0500 RESID (2S,3aR,8aS)-3a-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid RESID-systematic 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan RESID-name LIPID 3'-farnesyl-2',N2-cyclotryptophan UniProt-feature DiffAvg 204.36 DiffFormula C 15 H 24 N 0 O 0 DiffMono 204.187801 Formula C 26 H 34 N 2 O 1 MassAvg 390.57 MassMono 390.267114 Origin W Source natural TermSpec none MOD:00437 MOD:00601 MOD:01115 PSI-MOD MOD:01591 modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da Modifications that have monoisotopic mass differences from their respective origins of 304.205359 Da. 18688235 PubMed PSI-MOD-slim MOD:01515 MOD:01592 PSI-MOD MOD:01592 modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da Modifications that have monoisotopic mass differences from their respective origins of 304.199-304.206 Da. 18688235 PubMed PSI-MOD-slim MOD:01514 PSI-MOD MOD:01593 iTRAQ8plex reporter fragment A protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate MOD:01520 PSI-MOD MOD:01594 iTRAQ8plex-113 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-113 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 6 H 13 (14)N 2 MassAvg 113.11 MassMono 113.107325 Origin X Source artifact TermSpec none MOD:01593 derives_from MOD:015280 PSI-MOD MOD:01595 iTRAQ8plex-114 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-114 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 5 (13)C 1 H 13 (14)N 2 MassAvg 114.11 MassMono 114.110680 Origin X Source artifact TermSpec none MOD:01593 derives_from MOD:015350 PSI-MOD MOD:01596 iTRAQ8plex-115 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-115 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1 MassAvg 115.11 MassMono 115.107715 Origin X Source artifact TermSpec none MOD:01593 derives_from MOD:015420 PSI-MOD MOD:01597 iTRAQ8plex-116 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-116 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1 MassAvg 116.11 MassMono 116.111069 Origin X Source artifact TermSpec none MOD:01593 derives_from MOD:015490 PSI-MOD MOD:01598 iTRAQ8plex-117 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-117 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1 MassAvg 117.11 MassMono 117.114424 Origin X Source artifact TermSpec none MOD:01593 derives_from MOD:015560 PSI-MOD MOD:01599 iTRAQ8plex-118 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-118 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 3 (13)C 3 H 13 (15)N 2 MassAvg 118.11 MassMono 118.111459 Origin X Source artifact TermSpec none MOD:01593 derives_from MOD:015630 PSI-MOD MOD:01600 iTRAQ8plex-119 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-119 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 2 (13)C 4 H 13 (15)N 2 MassAvg 119.11 MassMono 119.114814 Origin X Source artifact TermSpec none MOD:01593 derives_from MOD:015700 PSI-MOD MOD:01601 iTRAQ8plex-121 reporter fragment The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-121 reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (13)C 6 H 13 (15)N 2 MassAvg 121.12 MassMono 121.121524 Origin X Source artifact TermSpec none MOD:01593 derives_from MOD:015770 PSI-MOD MOD:01602 S-(L-lysyl)-L-methionine sulfilimine A protein modification that effectively converts an L-lysine residue, and an L-methionine residue to S-(L-lysyl)-L-methionine sulfilimine. 12011424 PubMed 15951440 PubMed 19729652 PubMed AA0501 RESID Cross-link 2. (2S)-2-amino-6-([(E)-[(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene]amino)hexanoic acid RESID-systematic (E)-N6-([(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene)-L-lysine RESID-alternate S-(L-lysyl)-L-methionine sulfilimine RESID-name S-lysyl-methionine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 11 H 19 N 3 O 2 S 1 MassAvg 257.35 MassMono 257.119798 Origin K, M Source natural TermSpec none MOD:00912 MOD:00913 PSI-MOD MOD:01603 2x(15)N labeled L-lysine A protein modification that effectively converts an L-lysine residue to 2x(15)N labeled L-lysine. 18688235 PubMed PSI-MOD-slim DiffAvg 1.99 DiffFormula (14)N -2 (15)N 2 DiffMono 1.994070 Formula C 6 H 12 (15)N 2 O 1 MassAvg 130.09 MassMono 130.089033 Origin K Source artifact TermSpec none MOD:00843 MOD:00912 PSI-MOD MOD:01604 4x(15)N labeled L-arginine A protein modification that effectively converts an L-arginine residue to 4x(15)N labeled L-arginine. 18688235 PubMed PSI-MOD-slim DiffAvg 3.99 DiffFormula (14)N -4 (15)N 4 DiffMono 3.988140 Formula C 6 H 12 (15)N 4 O 1 MassAvg 160.09 MassMono 160.089251 Origin R Source artifact TermSpec none MOD:00843 MOD:00902 PSI-MOD MOD:01605 5-glutamyl 2-aminoadipic acid A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic acid. 19620981 PubMed AA0502 RESID (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanedioic acid RESID-systematic 5-glutamyl 2-aminoadipic acid RESID-name MOD_RES 5-glutamyl 2-aminoadipic acid UniProt-feature N2-(gamma-glutamyl)-2-aminoadipic acid RESID-alternate N2-(isoglutamyl)-2-aminoadipic acid RESID-alternate DiffAvg 143.14 DiffFormula C 6 H 9 N 1 O 3 DiffMono 143.058243 Formula C 11 H 16 N 2 O 6 MassAvg 272.26 MassMono 272.100836 Origin E Source natural TermSpec none MOD:00674 MOD:00906 PSI-MOD MOD:01606 5-glutamyl 2-aminoadipic 6-phosphoric anhydride A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic 6-phosphoric anhydride. 19620981 PubMed AA0503 RESID (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxo-6-(phosphonooxy)hexanoic acid RESID-systematic 5-glutamyl 2-aminoadipic 6-phosphoric anhydride RESID-name DiffAvg 223.12 DiffFormula C 6 H 10 N 1 O 6 P 1 DiffMono 223.024574 Formula C 11 H 17 N 2 O 9 P 1 MassAvg 352.24 MassMono 352.067167 Origin E Source hypothetical TermSpec none MOD:00674 MOD:00861 MOD:00906 PSI-MOD MOD:01607 5-glutamyl allysine A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl allysine. 19620981 PubMed AA0504 RESID (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxohexanoic acid RESID-systematic 2-(5-glutamyl)amino-6-oxohexanoic acid RESID-alternate 5-glutamyl allysine RESID-name alpha-(gamma-glutamyl)allysine RESID-alternate N2-(gamma-glutamyl)allysine RESID-alternate N2-(isoglutamyl)allysine RESID-alternate DiffAvg 127.14 DiffFormula C 6 H 9 N 1 O 2 DiffMono 127.063329 Formula C 11 H 16 N 2 O 5 MassAvg 256.26 MassMono 256.105922 Origin E Source hypothetical TermSpec none MOD:00674 MOD:00906 PSI-MOD MOD:01608 N2-(L-isoglutamyl)-L-lysine A protein modification that effectively converts an L-glutamic acid residue to N2-(L-isoglutamyl)-L-lysine. This is not an isopeptide cross-link. 19620981 PubMed AA0505 RESID (2S)-6-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid RESID-systematic 5-glutamyl N2-lysine RESID-alternate alpha-(gamma-glutamyl)lysine RESID-alternate gamma-glutamyl N2-lysine RESID-alternate MOD_RES 5-glutamyl N2-lysine UniProt-feature N2-(gamma-glutamyl)lysine RESID-alternate N2-(L-isoglutamyl)-L-lysine RESID-name DiffAvg 128.18 DiffFormula C 6 H 12 N 2 O 1 DiffMono 128.094963 Formula C 11 H 19 N 3 O 4 MassAvg 257.29 MassMono 257.137556 Origin E Source natural TermSpec none MOD:00906 PSI-MOD MOD:01609 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan. 19584055 PubMed AA0506 RESID (2S)-2-amino-3-[7-hydroxy-2-(alpha-D-mannopyranosyl)-1H-indol-3-yl]propanoic acid RESID-systematic 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan RESID-name MOD_RES 7'-hydroxytryptophan UniProt-feature DiffAvg 178.14 DiffFormula C 6 H 10 N 0 O 6 DiffMono 178.047738 Formula C 17 H 20 N 2 O 7 MassAvg 364.35 MassMono 364.127051 Origin W Source natural TermSpec none MOD:00918 has_functional_parent MOD:002220 has_functional_parent MOD:016640 PSI-MOD MOD:01610 L-threonine methyl ester A protein modification that effectively converts an L-threonine residue to L-threonine methyl ester. 19745839 PubMed AA0507 RESID L-threonine methyl ester RESID-name methyl (2S,3R)-2-amino-3-hydroxybutanoate RESID-systematic methyl L-threoninate RESID-alternate DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 5 H 10 N 1 O 3 MassAvg 132.14 MassMono 132.066068 Origin T Source natural TermSpec C-term MOD:01689 MOD:01803 PSI-MOD MOD:01611 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN. 17935335 PubMed AA0508 RESID Cross-link 2. PSI-MOD-slim 6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-trihydrogen phosphate RESID-systematic 6-(S-cysteinyl)-8alpha-(N(delta)-histidyl)-FMN RESID-alternate 6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FMN RESID-alternate 6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FMN RESID-alternate 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FMN RESID-alternate 6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FMN RESID-name BINDING FMN (covalent; via 2 links) UniProt-feature BINDING FMN (covalent; via 2 links, pros nitrogen) UniProt-feature DiffAvg 452.32 DiffFormula C 17 H 17 N 4 O 9 P 1 S 0 DiffMono 452.073315 Formula C 26 H 29 N 8 O 11 P 1 S 1 MassAvg 692.60 MassMono 692.141411 Origin C, H Source natural TermSpec none MOD:00896 MOD:00905 MOD:00909 MOD:01621 PSI-MOD MOD:01612 3'-iodo-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to 3'-iodo-L-tyrosine. 27847 ChEBI 8995307 PubMed AA0509 RESID PSI-MOD-slim (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid RESID-systematic 3'-iodo-L-tyrosine RESID-name 3-iodo-L-tyrosine RESID-alternate 3-iodotyrosine RESID-alternate 4-hydroxy-3-iodo-phenylalanine RESID-alternate MIT RESID-alternate MOD_RES Iodotyrosine UniProt-feature DiffAvg 125.90 DiffFormula C 0 H -1 I 1 N 0 O 0 DiffMono 125.896648 Formula C 9 H 8 I 1 N 1 O 2 MassAvg 289.07 MassMono 288.959976 Origin Y Source natural TermSpec none MOD:01228 PSI-MOD MOD:01613 3',5'-diiodo-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to 3',5'-diiodo-L-tyrosine. 15768 ChEBI 8995307 PubMed AA0510 RESID PSI-MOD-slim (2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid RESID-systematic 3',5'-diiodo-L-tyrosine RESID-name 3,5-diiodo-L-tyrosine RESID-alternate 3,5-diiodotyrosine RESID-alternate DIT RESID-alternate iodogorgoic acid RESID-alternate MOD_RES Diiodotyrosine UniProt-feature DiffAvg 251.79 DiffFormula C 0 H -2 I 2 N 0 O 0 DiffMono 251.793295 Formula C 9 H 7 I 2 N 1 O 2 MassAvg 414.97 MassMono 414.856624 Origin Y Source natural TermSpec none MOD:01140 PSI-MOD MOD:01614 glycyl phospho-5'-adenosine A protein modification that effectively converts a glycine residue to glycyl phospho-5'-adenosine. 16388576 PubMed 9632726 PubMed AA0511 RESID (2-aminoacetyl)oxy-([(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy)phosphinic acid RESID-alternate ([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl)-2-aminoethanoate RESID-alternate 5'-adenylic-glyinate RESID-alternate aminoacetyl [5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen phosphate RESID-systematic glycine monoanhydride with 5'-adenylic acid RESID-alternate glycyl 5'-adenylate RESID-alternate glycyl adenosine-5'-phosphate RESID-alternate glycyl phospho-5'-adenosine RESID-name glycyladenylate RESID-alternate MOD_RES Glycyl adenylate UniProt-feature DiffAvg 329.21 DiffFormula C 10 H 12 N 5 O 6 P 1 DiffMono 329.052520 Formula C 12 H 16 N 6 O 8 P 1 MassAvg 403.27 MassMono 403.076723 Origin G Source natural TermSpec C-term MOD:00908 MOD:01165 PSI-MOD MOD:01615 glycyl cysteine dithioester A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a dithioester bond to form glycyl cysteine dithioester. 11438688 PubMed 16388576 PubMed AA0512 RESID Cross-link 2. (2R)-2-amino-3-[(aminoacetyl)disulfanyl]propanoic acid RESID-systematic 2-(glycyldithio)alanine RESID-alternate glycyl cysteine dithioester RESID-name S-glycyl cysteine persulfide RESID-alternate S-glycyl thiocysteine RESID-alternate thioglycine cysteine disulfide RESID-alternate DiffAvg 14.05 DiffFormula C 0 H -2 N 0 O -1 S 1 DiffMono 13.961506 Formula C 5 H 7 N 2 O 2 S 2 MassAvg 191.24 MassMono 190.994894 Origin C, G Source hypothetical TermSpec C-term MOD:00395 MOD:00908 MOD:00954 PSI-MOD MOD:01616 trithiocystine A protein modification that effectively cross-links two L-cysteine residues and adds three sulfur atoms to form trithiocystine. 19438211 PubMed AA0513 RESID Cross-link 2. (2R,2'R)-3,3'-pentasulfane-1,5-diylbis(2-aminopropanoic acid) RESID-systematic 3,3'-pentathiobisalanine RESID-alternate bis(2-amino-2-carboxyethyl)pentasulfide RESID-alternate trithiocystine RESID-name DiffAvg 94.16 DiffFormula C 0 H -2 N 0 O 0 S 3 DiffMono 93.900563 Formula C 6 H 8 N 2 O 2 S 5 MassAvg 300.44 MassMono 299.918933 Origin C, C Source natural TermSpec none MOD:01620 PSI-MOD MOD:01617 O-(6-phosphomannosyl)-L-threonine A protein modification that effectively converts an L-threonine residue to O-(6-phosphomannosyl)-L-threonine. 20044576 PubMed AA0514 RESID (2S,3R)-2-amino-3-[6-phosphonooxy-alpha-D-mannopyranosyloxy]butanoic acid RESID-systematic O-(6-phosphomannosyl)-L-threonine RESID-name O3-(6-phosphomannosyl)threonine RESID-alternate DiffAvg 242.12 DiffFormula C 6 H 11 N 0 O 8 P 1 DiffMono 242.019154 Formula C 10 H 18 N 1 O 10 P 1 MassAvg 343.22 MassMono 343.066832 Origin T Source natural TermSpec none MOD:00005 MOD:00595 PSI-MOD MOD:01618 L-alanyl-L-isoaspartyl cyclopeptide A protein modification that effectively converts an L-alaine residue and an L-asparagine residue to L-alanyl-L-isoaspartyl cyclopeptide. 19928958 PubMed 3207697 PubMed AA0515 RESID Cross-link 2. (2S,5S)-2-methyl-3,7-dioxo-1,4-diazepane-5-carboxylic acid RESID-systematic 1,4.2-anhydro(L-alanyl-L-aspartic acid) RESID-alternate CROSSLNK Alanine isoaspartyl cyclopeptide (Ala-Asn) UniProt-feature L-alanyl-L-isoaspartyl cyclopeptide RESID-name DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 7 H 9 N 2 O 3 MassAvg 169.16 MassMono 169.061317 Origin A, N Source natural TermSpec N-term MOD:00688 MOD:00901 MOD:00903 MOD:00946 PSI-MOD MOD:01619 multisulfide crosslinked residues A protein modification that crosslinks two cysteine residues by formation of a chain of two or more bonded sulfur atoms. 18688235 PubMed PSI-MOD-slim MOD:00033 MOD:00905 PSI-MOD MOD:01620 polysulfide crosslinked residues A protein modification that crosslinks two cysteine residues by formation of a chain of three or more bonded sulfur atoms. 18688235 PubMed MOD:00860 MOD:01619 PSI-MOD MOD:01621 flavin crosslinked residues A protein modification that crosslinks two or more amino acid residues by forming an adduct with a compound containing a flavin group. 18688235 PubMed PSI-MOD-slim MOD:00033 MOD:00697 PSI-MOD MOD:01622 monohydroxylated tryptophan A protein modification that effectively converts an L-tryptophan residue to one of several monohydroxylated tryptophan residues, including 3-hydroxy-L-tryptophan and 7'-hydroxy-L-tryptophan. 35#W UniMod Oxidation PSI-MS-label oxyw OMSSA-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 11 H 10 N 2 O 2 MassAvg 202.21 MassMono 202.074228 Origin W Source natural TermSpec none MOD:00425 MOD:00918 PSI-MOD MOD:01623 1-thioglycine (C-terminal) A protein modification that effectively converts a glycine residue to a C-terminal 1-thioglycine. 11463785 PubMed 19145231 PubMed 9367957 PubMed AA0265#var RESID PSI-MOD-slim DiffAvg 16.06 DiffFormula C 0 H 0 N 0 O -1 S 1 DiffMono 15.977156 Formula C 2 H 3 N 1 S 1 MassAvg 73.11 MassMono 72.998620 Origin G Source natural TermSpec C-term MOD:01625 PSI-MOD MOD:01624 (2-aminosuccinimidyl)acetic acid (Asn) A protein modification that crosslinks an asparagine and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the release of ammonia. 10801322 PubMed 2015294 PubMed AA0441#ASN RESID Cross-link 2. PSI-MOD-slim (2-aminosuccinimidyl)acetic acid RESID-name (3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid RESID-alternate [(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid RESID-systematic anhydroaspartyl glycine RESID-alternate aspartimide glycine RESID-alternate CROSSLNK (2-aminosuccinimidyl)acetic acid (Asn-Gly) UniProt-feature N-(2-aminosuccinyl)glycine RESID-alternate DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 6 H 6 N 2 O 3 MassAvg 154.13 MassMono 154.037842 Origin G, N Source hypothetical TermSpec none MOD:00903 MOD:00946 MOD:01628 PSI-MOD MOD:01625 1-thioglycine A protein modification that effectively converts a glycine residue to 1-thioglycine. 11463785 PubMed 9367957 PubMed AA0265 RESID This modification occurs naturally in two forms. At an interior peptide location (MOD:00270) it exists as aminoethanethionic acid, or aminoethanethioic O-acid. At the C-terminal (MOD:01623) it exists as aminoethanethiolic acid, or aminoethanethioic S-acid [JSG]. PSI-MOD-slim 1-thioglycine RESID-name 2-amino-1-sulfanylethanone RESID-alternate aminoethanethioic acid RESID-systematic aminothioacetic acid RESID-alternate Carboxy->Thiocarboxy PSI-MS-label MOD_RES 1-thioglycine UniProt-feature S(O)Gly PSI-MOD-label thiocarboxylic acid UniMod-description DiffAvg 16.06 DiffFormula C 0 H 0 N 0 O -1 S 1 DiffMono 15.977156 Formula none MassAvg none MassMono none Origin G Source natural MOD:00749 MOD:00908 PSI-MOD MOD:01626 L-cystine A protein modification that forms L-cystine by forming a disulfide bond that either cross-links two peptidyl L-cysteine residues, or modifies a peptidyl cysteine with a free cysteine. 16283 ChEBI 1988019 PubMed 2001356 PubMed 2076469 PubMed 3083866 PubMed 366603 PubMed 7918467 PubMed 8344916 PubMed AA0025 RESID This modification occurs naturally in two forms. It exists as a disulfide cross-link of two cysteine residues (MOD:00034), or as a disulfide cross-link of a cysteine residues and a free cysteine (MOD:00765). PSI-MOD-slim (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) RESID-systematic 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid RESID-misnomer 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) RESID-alternate 3,3'-dithiobis(2-aminopropanoic acid) RESID-alternate 3,3'-dithiobisalanine RESID-alternate 3,3'-dithiodialanine RESID-alternate beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide RESID-alternate beta,beta'-dithiodialanine RESID-alternate bis(alpha-aminopropionic acid)-beta-disulfide RESID-alternate bis(beta-amino-beta-carboxyethyl)disulfide RESID-alternate Cys2 PSI-MOD-label Cystine ((Cys)2) DeltaMass-label dicysteine RESID-alternate L-cystine RESID-name DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula none MassAvg none MassMono none Origin none Source natural TermSpec none MOD:00905 PSI-MOD MOD:01627 L-cysteinyl-L-selenocysteine A protein modification that forms L-cysteinyl-L-selenocysteine either by the natural process of cross-linking an L-cysteine residue and an L-selenocysteine residue, or by the hypothetical process of substituting a selenium for a sulfur atom in cystine. 12911312 PubMed 18688235 PubMed Cross-link 2. PSI-MOD-slim DiffAvg none DiffFormula none DiffMono none Formula C 6 H 8 N 2 O 2 S 1 Se 1 MassAvg 251.17 MassMono 251.947170 Origin C, X Source natural TermSpec none MOD:00692 MOD:00859 MOD:00905 PSI-MOD MOD:01628 (2-aminosuccinimidyl)acetic acid A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following glycine residue. 10801322 PubMed 18688235 PubMed Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. PSI-MOD-slim DiffAvg none DiffFormula none DiffMono none Formula C 6 H 6 N 2 O 3 MassAvg 154.13 MassMono 154.037842 Origin G, X Source hypothetical TermSpec none MOD:00908 MOD:01944 PSI-MOD MOD:01629 cyclo[(prolylserin)-O-yl] cysteinate A protein modification that forms cyclo[(prolylserin)-O-yl] cysteinate by the natural process of cross-linking an L-cysteine residue an L-proline residue, and an L-serine residue, or by effectively modifying a cysteine residue. 7961166 PubMed AA0489 RESID (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate RESID-alternate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate RESID-systematic cyclo[(prolylserin)-O-yl] cysteinate RESID-name MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate UniProt-feature DiffAvg none DiffFormula none DiffMono none Formula C 11 H 16 N 3 O 4 S 1 MassAvg 286.33 MassMono 286.086152 Origin X Source natural TermSpec C-term MOD:00859 MOD:00905 PSI-MOD MOD:01630 N6-(L-isoglutamyl)-L-lysine A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine . 21863 ChEBI 0 DeltaMass 2461365 PubMed 5637041 PubMed 5656070 PubMed 8598899 PubMed AA0124 RESID Cross-link 2. PSI-MOD-slim (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid RESID-systematic 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid RESID-alternate 5-glutamyl N6-lysine RESID-alternate N alpha -(gamma-Glutamyl)-lysine DeltaMass-label N(epsilon)-(gamma-glutamyl)lysine RESID-alternate N6-(L-isoglutamyl)-L-lysine RESID-name DiffAvg none DiffFormula none DiffMono none Formula C 11 H 17 N 3 O 3 MassAvg 239.27 MassMono 239.126991 Origin K, X Source natural TermSpec none MOD:00688 MOD:00859 MOD:01875 PSI-MOD MOD:01631 L-alanine removal A protein modification that effectively removes or replaces an L-alanine. 18688235 PubMed This represents the loss or replacement of an L-alanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -71.08 DiffFormula C -3 H -5 N -1 O -1 DiffMono -71.037114 Formula none MassAvg none MassMono none Origin A Source natural TermSpec none MOD:00901 MOD:01651 PSI-MOD MOD:01632 L-arginine removal A protein modification that effectively removes or replaces an L-arginine. 18688235 PubMed This represents the loss or replacement of an L-arginine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -156.19 DiffFormula C -6 H -12 N -4 O -1 DiffMono -156.101111 Formula none MassAvg none MassMono none Origin R Source natural TermSpec none MOD:00902 MOD:01651 PSI-MOD MOD:01633 L-asparagine removal A protein modification that effectively removes or replaces an L-asparagine. 18688235 PubMed This represents the loss or replacement of an L-asparagine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -114.10 DiffFormula C -4 H -6 N -2 O -2 DiffMono -114.042927 Formula none MassAvg none MassMono none Origin N Source natural TermSpec none MOD:00903 MOD:01651 PSI-MOD MOD:01634 L-aspartic acid removal A protein modification that effectively removes or replaces an L-aspartic acid. 18688235 PubMed This represents the loss or replacement of an L-aspartic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -115.09 DiffFormula C -4 H -5 N -1 O -3 DiffMono -115.026943 Formula none MassAvg none MassMono none Origin D Source natural TermSpec none MOD:00904 MOD:01651 PSI-MOD MOD:01635 L-cysteine removal A protein modification that effectively removes or replaces an L-cysteine. 18688235 PubMed This represents the loss or replacement of an L-cysteine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -103.14 DiffFormula C -3 H -5 N -1 O -1 S -1 DiffMono -103.009185 Formula none MassAvg none MassMono none Origin C Source natural TermSpec none MOD:00905 MOD:01651 PSI-MOD MOD:01636 L-glutamic acid removal A protein modification that effectively removes or replaces an L-glutamic acid. 18688235 PubMed This represents the loss or replacement of an L-glutamic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -129.12 DiffFormula C -5 H -7 N -1 O -3 DiffMono -129.042593 Formula none MassAvg none MassMono none Origin E Source natural TermSpec none MOD:00906 MOD:01651 PSI-MOD MOD:01637 L-glutamine removal A protein modification that effectively removes or replaces an L-glutamine. 18688235 PubMed This represents the loss or replacement of an L-glutamine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -128.13 DiffFormula C -5 H -8 N -2 O -2 DiffMono -128.058578 Formula none MassAvg none MassMono none Origin Q Source natural TermSpec none MOD:00907 MOD:01651 PSI-MOD MOD:01638 glycine removal A protein modification that effectively removes or replaces a glycine. 18688235 PubMed This represents the loss or replacement of an glycine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -57.05 DiffFormula C -2 H -3 N -1 O -1 DiffMono -57.021464 Formula none MassAvg none MassMono none Origin G Source natural TermSpec none MOD:00908 MOD:01651 PSI-MOD MOD:01639 L-histidine removal A protein modification that effectively removes or replaces an L-histidine. 18688235 PubMed This represents the loss or replacement of an L-histidine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -137.14 DiffFormula C -6 H -7 N -3 O -1 DiffMono -137.058912 Formula none MassAvg none MassMono none Origin H Source natural TermSpec none MOD:00909 MOD:01651 PSI-MOD MOD:01640 L-isoleucine removal A protein modification that effectively removes or replaces an L-isoleucine. 18688235 PubMed This represents the loss or replacement of an L-isoleucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -113.16 DiffFormula C -6 H -11 N -1 O -1 DiffMono -113.084064 Formula none MassAvg none MassMono none Origin I Source natural TermSpec none MOD:00910 MOD:01651 PSI-MOD MOD:01641 L-leucine removal A protein modification that effectively removes or replaces an L-leucine. 18688235 PubMed This represents the loss or replacement of an L-leucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -113.16 DiffFormula C -6 H -11 N -1 O -1 DiffMono -113.084064 Formula none MassAvg none MassMono none Origin L Source natural TermSpec none MOD:00911 MOD:01651 PSI-MOD MOD:01642 L-lysine removal A protein modification that effectively removes or replaces an L-lysine. 18688235 PubMed This represents the loss or replacement of an L-lysine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -128.18 DiffFormula C -6 H -12 N -2 O -1 DiffMono -128.094963 Formula none MassAvg none MassMono none Origin K Source natural TermSpec none MOD:00912 MOD:01651 PSI-MOD MOD:01643 L-methionine removal A protein modification that effectively removes or replaces an L-methionine. 3327521 PubMed 765 UniMod This represents the loss or replacement of an L-methionine residue in a polypeptide, including initiator methionine removal in eukaryotes. It may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution [JSG]. PSI-MOD-slim Met-loss UniMod-interim ntermmcleave OMSSA-label DiffAvg -131.19 DiffFormula C -5 H -9 N -1 O -1 S -1 DiffMono -131.040485 Formula none MassAvg none MassMono none Origin M Source natural TermSpec none MOD:00913 MOD:01651 PSI-MOD MOD:01644 L-phenylalanine removal A protein modification that effectively removes or replaces an L-phenylalanine. 18688235 PubMed This represents the loss or replacement of an L-phenylalanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -147.18 DiffFormula C -9 H -9 N -1 O -1 DiffMono -147.068414 Formula none MassAvg none MassMono none Origin F Source natural TermSpec none MOD:00914 MOD:01651 PSI-MOD MOD:01645 L-proline removal A protein modification that effectively removes or replaces an L-proline. 18688235 PubMed This represents the loss or replacement of an L-proline residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -97.12 DiffFormula C -5 H -7 N -1 O -1 DiffMono -97.052764 Formula none MassAvg none MassMono none Origin P Source natural TermSpec none MOD:00915 MOD:01651 PSI-MOD MOD:01646 L-serine removal A protein modification that effectively removes or replaces an L-serine. 18688235 PubMed This represents the loss or replacement of an L-serine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -87.08 DiffFormula C -3 H -5 N -1 O -2 DiffMono -87.032028 Formula none MassAvg none MassMono none Origin S Source natural TermSpec none MOD:00916 MOD:01651 PSI-MOD MOD:01647 L-threonine removal A protein modification that effectively removes or replaces an L-threonine. 18688235 PubMed This represents the loss or replacement of an L-threonine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -101.10 DiffFormula C -4 H -7 N -1 O -2 DiffMono -101.047678 Formula none MassAvg none MassMono none Origin T Source natural TermSpec none MOD:00917 MOD:01651 PSI-MOD MOD:01648 L-tryptophan removal A protein modification that effectively removes or replaces an L-tryptophan. 18688235 PubMed This represents the loss or replacement of an L-tryptophan residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -186.21 DiffFormula C -11 H -10 N -2 O -1 DiffMono -186.079313 Formula none MassAvg none MassMono none Origin W Source natural TermSpec none MOD:00918 MOD:01651 PSI-MOD MOD:01649 L-tyrosine removal A protein modification that effectively removes or replaces an L-tyrosine. 18688235 PubMed This represents the loss or replacement of an L-tyrosine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -163.18 DiffFormula C -9 H -9 N -1 O -2 DiffMono -163.063329 Formula none MassAvg none MassMono none Origin Y Source natural TermSpec none MOD:00919 MOD:01651 PSI-MOD MOD:01650 L-valine removal A protein modification that effectively removes or replaces an L-valine. 18688235 PubMed This represents the loss or replacement of an L-valine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim DiffAvg -99.13 DiffFormula C -5 H -9 N -1 O -1 DiffMono -99.068414 Formula none MassAvg none MassMono none Origin V Source natural TermSpec none MOD:00920 MOD:01651 PSI-MOD MOD:01651 natural, standard, encoded residue removal A protein modification that effectively removes or replaces a natural, standard, encoded residue. 18688235 PubMed This represents the loss or replacement of an encoded residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. PSI-MOD-slim Origin X Source natural TermSpec none MOD:00009 PSI-MOD MOD:01652 sulfonyl halide reagent derivatized residue A protein modification that is produced by formation of an adduct with a sulfonyl halide compound used as a reagent. 18688235 PubMed These reagents typically react with N6-amino group of lysine residues and a free alpha-amino group of a peptide. Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01653 dansyl chloride derivatized residue A protein modification that is produced by formation of an adduct with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride. 0 DeltaMass 139 UniMod 5-dimethylaminonaphthalene-1-sulfonyl UniMod-description Dansyl PSI-MS-label Dansyl (Dns) DeltaMass-label DansylRes PSI-MOD-label DiffAvg 233.29 DiffFormula C 12 H 11 N 1 O 2 S 1 DiffMono 233.051050 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01652 PSI-MOD MOD:01654 N6-Dansyl derivatized lysine A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form N6-Dansyl-lysine. 139#K UniMod 5-dimethylaminonaphthalene-1-sulfonyl UniMod-description Dansyl PSI-MS-label N6DansylLys PSI-MOD-label DiffAvg 233.29 DiffFormula C 12 H 11 N 1 O 2 S 1 DiffMono 233.051050 Formula C 18 H 23 N 3 O 3 S 1 MassAvg 361.46 MassMono 361.146013 Origin K Source artifact TermSpec none MOD:00912 MOD:01653 PSI-MOD MOD:01655 alpha-amino-Dansyl derivatized residue A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form an alpha-amino-Dansyl-derivatized residue. 139#N-term UniMod 5-dimethylaminonaphthalene-1-sulfonyl UniMod-description Dansyl PSI-MS-label N2DansylRes PSI-MOD-label DiffAvg 233.29 DiffFormula C 12 H 11 N 1 O 2 S 1 DiffMono 233.051050 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01653 PSI-MOD MOD:01656 Dabsyl chloride derivatized residue A protein modification that is produced by formation of an adduct with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, Dabsyl chloride. 18688235 PubMed 4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl PSI-MOD-alternate DabsylRes PSI-MOD-label DiffAvg 287.34 DiffFormula C 14 H 13 N 3 O 2 S 1 DiffMono 287.072848 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01652 PSI-MOD MOD:01657 N6-Dabsyl derivatized lysine A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form N6-Dabsyl-lysine. 18688235 PubMed N6-[4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl]lysine PSI-MOD-alternate N6DabsylLys PSI-MOD-label DiffAvg 287.34 DiffFormula C 14 H 13 N 3 O 2 S 1 DiffMono 287.072848 Formula C 20 H 25 N 5 O 3 S 1 MassAvg 415.51 MassMono 415.167811 Origin K Source artifact TermSpec none MOD:00912 MOD:01656 PSI-MOD MOD:01658 alpha-amino-Dabsyl derivatized residue A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form an alpha-amino-Dabsyl-derivatized residue. 18688235 PubMed N2DabsylRes PSI-MOD-label DiffAvg 287.34 DiffFormula C 14 H 13 N 3 O 2 S 1 DiffMono 287.072848 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01656 PSI-MOD MOD:01659 Uniblue A derivatized residue A protein modification that is produced by formation of an adduct with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A. 18688235 PubMed This reagent has a reactive sulfonyl vinyl and typically reacts with the free thiol group of cysteine residues. 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid PSI-MOD-alternate 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonic acid PSI-MOD-alternate Uniblue A PSI-MOD-alternate UniblueARes PSI-MOD-label DiffAvg 484.50 DiffFormula C 22 H 16 N 2 O 7 S 2 DiffMono 484.039893 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01660 Uniblue A derivatized cysteine A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A cysteine adduct. 18688235 PubMed PSI-MOD-slim 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate PSI-MOD-alternate 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate PSI-MOD-alternate SUniblueACys PSI-MOD-label Uniblue A PSI-MOD-alternate DiffAvg 484.50 DiffFormula C 22 H 16 N 2 O 7 S 2 DiffMono 484.039893 Formula C 25 H 21 N 3 O 8 S 3 MassAvg 587.64 MassMono 587.049078 Origin C Source artifact TermSpec none MOD:00905 MOD:01659 PSI-MOD MOD:01661 pyruvic acid (Tyr) A protein modification that effectively converts an L-tyrosine residue to pyruvic acid. 10085076 PubMed 3042771 PubMed 500639 PubMed 8464063 PubMed AA0127#TYR RESID 2-oxopropanoic acid RESID-systematic MOD_RES Pyruvic acid (Tyr) UniProt-feature pyruvic acid RESID-name DiffAvg -93.13 DiffFormula C -6 H -7 N -1 O 0 DiffMono -93.057849 Formula C 3 H 3 O 2 MassAvg 71.06 MassMono 71.013304 Origin Y Source natural TermSpec N-term MOD:00919 MOD:01154 PSI-MOD MOD:01662 N5-(ADP-ribosyl)-L-glutamine A protein modification that effectively converts an L-glutamine residue to N5-(ADP-ribosyl)-L-glutamine. 20185726 PubMed AA0518 RESID (S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-5-oxopentanoic acid RESID-systematic N5-(ADP-ribosyl)-L-glutamine RESID-name N5-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-glutamine RESID-alternate N5-alpha-D-ribofuranosyl-L-glutamine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) RESID-alternate DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 20 H 29 N 7 O 15 P 2 MassAvg 669.43 MassMono 669.119687 Origin Q Source natural TermSpec none MOD:00752 MOD:00907 PSI-MOD MOD:01663 O-(ADP-ribosyl)-L-threonine A protein modification that effectively converts an L-threonine residue to O-(ADP-ribosyl)-L-threonine. 20185726 PubMed AA0519 RESID (S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-butanoic acid RESID-systematic O-(ADP-ribosyl)-L-threonine RESID-name O3-(ADP-ribosyl)-L-threonine RESID-alternate O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-threonine RESID-alternate O3-alpha-D-ribofuranosyl-L-threonine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) RESID-alternate DiffAvg 541.30 DiffFormula C 15 H 21 N 5 O 13 P 2 DiffMono 541.061109 Formula C 19 H 28 N 6 O 15 P 2 MassAvg 642.41 MassMono 642.108787 Origin T Source natural TermSpec none MOD:00752 MOD:00917 PSI-MOD MOD:01664 7'-hydroxy-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to a 7'-hydroxy-L-tryptophan. 20223990 PubMed AA0520 RESID (2S)-2-amino-3-(7-hydroxy-1H-indol-3-yl)propanoic acid RESID-systematic 7'-hydroxy-L-tryptophan RESID-name 7-hydroxy-L-tryptophan RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 11 H 10 N 2 O 2 MassAvg 202.21 MassMono 202.074228 Origin W Source natural TermSpec none MOD:01622 PSI-MOD MOD:01665 N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine A protein modification that effectively crosslinks an N-terminal L-valine residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine. 20185759 PubMed AA0521 RESID (2S)-2-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]amino-3-methylbutanoic acid RESID-systematic ACT_SITE Schiff-base intermediate with DNA; via amino nitrogen UniProt-feature DNA glycosylase valine Schiff base intermediate RESID-alternate N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine RESID-name DiffAvg 178.08 DiffFormula C 5 H 7 N 0 O 5 P 1 DiffMono 178.003110 Formula C 10 H 17 N 1 O 6 P 1 MassAvg 278.22 MassMono 278.079349 Origin V Source hypothetical TermSpec N-term MOD:00750 MOD:00920 PSI-MOD MOD:01666 epicocconone derivatized residue A protein modification that is produced by formation of an adduct with epicocconone. 18688235 PubMed (6S,9aS)-6-(hydroxymethyl)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-9a-methyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione PSI-MOD-alternate Deep Purple PSI-MOD-alternate LavaPurple PSI-MOD-alternate Lightning Fast PSI-MOD-alternate DiffAvg 410.42 DiffFormula C 23 H 22 O 7 DiffMono 410.136553 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00848 PSI-MOD MOD:01667 N6-epicoccononyl lysine adduct A protein modification that is produced by formation of an adduct with epicocconone. 18688235 PubMed (6Z,7aS)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-7a-methyl-6-[([(1S)-1-amino-1-carboxylpentyl]amino)methylidene]-5-[(2S)-2,3-dihydroxypropyl]-1-benzofuran-2,7(6H,7aH)-dione PSI-MOD-alternate DeepPurple PSI-MOD-alternate LavaPurple PSI-MOD-alternate Lightning Fast PSI-MOD-alternate DiffAvg 410.42 DiffFormula C 23 H 22 O 7 DiffMono 410.136553 Formula C 29 H 34 N 2 O 8 MassAvg 538.60 MassMono 538.231516 Origin K Source artifact TermSpec none MOD:00912 MOD:01666 PSI-MOD MOD:01668 O4-(8alpha-FAD)-L-aspartate A protein modification that effectively converts an L-aspartic acid residue to O4-(8alpha-FAD)-L-aspartate. 20080101 PubMed AA0522 RESID PSI-MOD-slim (2S)-2-amino-4-oxo-4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxybutanoic acid RESID-systematic 8alpha-[(4-aspartyl)oxy]FAD RESID-alternate O4-(8alpha-FAD)-L-aspartate RESID-name DiffAvg 783.54 DiffFormula C 27 H 31 N 9 O 15 P 2 DiffMono 783.141485 Formula C 31 H 36 N 10 O 18 P 2 MassAvg 898.63 MassMono 898.168428 Origin D Source natural TermSpec none MOD:00895 MOD:00904 PSI-MOD MOD:01669 trimethyl-L-arginine A protein modification that effectively converts an L-arginine residue to N(omega),N(omega),N'(omega)-trimethyl-L-arginine. 11704273 PubMed 602668 PubMed AA0523 RESID 37#R UniMod (2S)-2-amino-5-([(dimethylamino)(methylamino)methylidene]amino)pentanoic acid RESID-systematic (2S)-2-amino-5-([(dimethylamino)(methylimino)methyl]amino)pentanoic acid RESID-alternate 2-[(4S)-4-amino-5-oxopentyl]-1,1,3-trimethylguanidine RESID-alternate N(G)-trimethylarginine RESID-alternate N5-[(dimethylamino)(imino)methyl]ornithine RESID-alternate NoNoNo'Me3Arg PSI-MOD-label omega-N,omega-N,omega-N'-trimethyl-L-arginine RESID-name tri-Methylation UniMod-description Trimethyl PSI-MS-label trimethylationr OMSSA-label DiffAvg 42.08 DiffFormula C 3 H 6 N 0 O 0 DiffMono 42.046950 Formula C 9 H 18 N 4 O 1 MassAvg 198.27 MassMono 198.148061 Origin R Source hypothetical TermSpec none MOD:00430 MOD:00602 MOD:00658 PSI-MOD MOD:01670 N6-chloro-L-lysine A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. 16091367 PubMed 16195462 PubMed 17260957 PubMed AA0524 RESID (2S)-2-amino-6-(chloroamino)hexanoic acid RESID-systematic epsilon-chlorolysine RESID-alternate lysine chloramine RESID-alternate N(zeta)-chlorolysine RESID-alternate N6-chloro-L-lysine RESID-name N6ClLys PSI-MOD-label DiffAvg 34.44 DiffFormula C 0 Cl 1 H -1 N 0 O 0 DiffMono 33.961028 Formula C 6 Cl 1 H 11 N 2 O 1 MassAvg 162.62 MassMono 162.055991 Origin K Source hypothetical TermSpec none MOD:00912 MOD:01672 MOD:01911 PSI-MOD MOD:01671 O-(L-isoaspartyl)-L-threonine (active site intermediate) A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using free L-asparagine and releasing ammonia. 8706862 PubMed AA0525#THR RESID This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid RESID-systematic (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid RESID-alternate ACT_SITE O-isoaspartyl threonine intermediate UniProt-feature O(beta)-(beta-aspartyl)threonine RESID-alternate O-(L-isoaspartyl)-L-threonine RESID-name O3-(isoaspartyl)-threonine RESID-alternate DiffAvg 115.09 DiffFormula C 4 H 5 N 1 O 3 DiffMono 115.026943 Formula C 8 H 12 N 2 O 5 MassAvg 216.19 MassMono 216.074621 Origin T Source natural TermSpec none MOD:00671 MOD:01978 PSI-MOD MOD:01672 halogenated lysine A protein modification that effectively substitutes a hydrogen atom of an L-lysine residue with a halogen atom. 18688235 PubMed Origin K Source none TermSpec none MOD:00694 PSI-MOD MOD:01673 N-acetylaminohexosylated residue A protein modification that effectively replaces a hydrogen atom with an N-acetylaminohexose group through a glycosidic bond. 43 UniMod PSI-MOD-slim HexNAc PSI-MS-label HexNAcRes PSI-MOD-label N-Acetylhexosamine UniMod-description DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00436 PSI-MOD MOD:01674 N4-(N-acetylamino)hexosyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminohexosyl)-L-asparagine. 43#N UniMod PSI-MOD-slim (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)amino-4-oxobutanoic acid PSI-MOD-alternate HexNAc PSI-MS-label HexNAcAsn PSI-MOD-label hexNAcN OMSSA-label N-Acetylhexosamine UniMod-description N4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-asparagine PSI-MOD-alternate N4-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-asparagine PSI-MOD-alternate N4-(N-acetylhexosaminyl)asparagine PSI-MOD-alternate N4-asparagine-beta-N-acetylhexosaminide PSI-MOD-alternate N4-glycosyl-L-asparagine PSI-MOD-alternate N4-glycosylasparagine PSI-MOD-alternate N4HexNAcAsn PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 12 H 19 N 3 O 7 MassAvg 317.30 MassMono 317.122300 Origin N Source natural TermSpec none MOD:00160 MOD:01673 PSI-MOD MOD:01675 O-(N-acetylamino)hexosyl-L-serine A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminohexosyl)-L-serine. 43#S UniMod PSI-MOD-slim (S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-hexopyranosyloxy)propanoic acid PSI-MOD-alternate HexNAc PSI-MS-label hexNAcS OMSSA-label N-Acetylhexosamine UniMod-description O-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-serine PSI-MOD-alternate O-(N-acetylhexosaminyl)serine PSI-MOD-alternate O-glycosylserine PSI-MOD-alternate O-seryl-beta-N-acetylhexosaminide PSI-MOD-alternate O3-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-serine PSI-MOD-alternate OHexNAcSer PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 11 H 18 N 2 O 7 MassAvg 290.27 MassMono 290.111401 Origin S Source natural TermSpec none MOD:00002 MOD:01673 PSI-MOD MOD:01676 O-(N-acetylamino)hexosyl-L-threonine A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminohexosyl)-L-threonine. 43#T UniMod PSI-MOD-slim (2S,3R)-2-amino-3-(alpha-D-2-acetamido-2-deoxyhexopyranosyloxy)butanoic acid PSI-MOD-alternate HexNAc PSI-MS-label hexNAcT OMSSA-label N-Acetylhexosamine UniMod-description O-(N-acetylhexcosaminyl)-L-threonine PSI-MOD-alternate O-glycosylthreonine PSI-MOD-alternate O3-(N-acetylhexosaminyl)threonine PSI-MOD-alternate OHexNAcThr PSI-MOD-label DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 12 H 20 N 2 O 7 MassAvg 304.30 MassMono 304.127051 Origin T Source natural TermSpec none MOD:00005 MOD:01673 PSI-MOD MOD:01677 O4-(N-acetylamino)hexosyl-L-hydroxyproline A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)hexosyl-L-hydroxyproline. 18688235 PubMed secondary to RESID:AA0030 PSI-MOD-slim (2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-hexopyranosyloxy]pyrrolidine-2-carboxylic acid PSI-MOD-alternate 4-(N-acetylhexosaminyloxy)proline PSI-MOD-alternate 4-[(2-N-acetylamino)-alpha-D-hexopyranosyl]oxyproline PSI-MOD-alternate alpha-2-(N-acetylamino)hexopyranosyl-4-hydroxyproline PSI-MOD-alternate HexNAc PSI-MS-label O4-glycosyl-hydroxyproline PSI-MOD-alternate O4HexNAcHyPro PSI-MOD-label DiffAvg 219.19 DiffFormula C 8 H 13 N 1 O 6 DiffMono 219.074287 Formula C 13 H 20 N 2 O 7 MassAvg 316.31 MassMono 316.127051 Origin P Source natural TermSpec none MOD:00915 MOD:01673 PSI-MOD MOD:01678 N6-carbamoyl-L-lysine A protein modification that effectively coverts L-lysine to N6-carbamoyl-L-lysine. 56 DeltaMass 10978403 PubMed 12203680 PubMed 5#K UniMod This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation in solution [JSG]. PSI-MOD-slim 2-amino-6-ureido-hexanoic acid PSI-MOD-alternate Carbamyl UniMod-interim Carbamylation UniMod-description carbamylk OMSSA-label homocitrulline PSI-MOD-alternate N6-(aminocarbonyl)-L-lysine PSI-MOD-alternate N6CbmLys PSI-MOD-label DiffAvg 43.02 DiffFormula C 1 H 1 N 1 O 1 DiffMono 43.005814 Formula C 7 H 13 N 3 O 2 MassAvg 171.20 MassMono 171.100777 Origin K Source artifact TermSpec none MOD:00398 PSI-MOD MOD:01679 alpha-aminocarbamoylated residue A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a carbamoyl group. 56 DeltaMass 10978403 PubMed 12203680 PubMed 5#N-term UniMod This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation. This modification effectively blocks Edman degradation, and because it can dehydrate to a cyanate group and react with another peptide N-terminal, it can effectively block two peptide molecules [JSG]. PSI-MOD-slim Carbamyl UniMod-interim Carbamylation UniMod-description N2CbmRes PSI-MOD-label ntermcarbamyl OMSSA-label DiffAvg 43.02 DiffFormula C 1 H 1 N 1 O 1 DiffMono 43.005814 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00398 PSI-MOD MOD:01680 alpha-amino monomethylated residue A protein modification that effectively replaces one residue alpha amino or imino hydrogen with one methyl group. 34#N-term UniMod Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. PSI-MOD-slim Methyl PSI-MS-label Methylation UniMod-description N2Me1Res PSI-MOD-label ntermmethyl OMSSA-label ntermpepmethyl OMSSA-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula none MassAvg none MassMono none Origin X Source natural TermSpec N-term MOD:00599 MOD:01460 PSI-MOD MOD:01681 monomethylated L-aspartic acid A protein modification that effectively replaces one hydrogen atom of an L-aspartic acid residue with one methyl group. 34#D UniMod Me1Asp PSI-MOD-label Methyl PSI-MS-label Methylation UniMod-description methyld OMSSA-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 5 H 7 N 1 O 3 MassAvg 129.12 MassMono 129.042593 Origin D Source artifact TermSpec none MOD:00599 MOD:00887 PSI-MOD MOD:01682 monomethylated L-cysteine A protein modification that effectively replaces one hydrogen atom of an L-cysteine residue with one methyl group. 34#C UniMod PSI-MOD-slim Me1Cys PSI-MOD-label Methyl PSI-MS-label Methylation UniMod-description methylc OMSSA-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 4 H 7 N 1 O 1 S 1 MassAvg 117.17 MassMono 117.024835 Origin C Source natural TermSpec none MOD:00599 MOD:00660 PSI-MOD MOD:01683 monomethylated L-lysine A protein modification that effectively replaces one hydrogen atom of an L-lysine residue with one methyl group. PSI-MOD-slim Me1Lys PSI-MOD-label Methyl PSI-MS-label Methylation UniMod-description methylk OMSSA-label DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 7 H 15 N 2 O 2 MassAvg 159.21 MassMono 159.113353 Origin K Source natural TermSpec none MOD:00599 MOD:00663 PSI-MOD MOD:01684 palmitoylated-L-cysteine A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine. 47 UniMod PSI-MOD-slim Palmitoyl PSI-MS-label Palmitoylation UniMod-description palmitoylationc OMSSA-label PamCys PSI-MOD-label DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 S 0 DiffMono 238.229666 Formula C 19 H 35 N 1 O 2 S 1 MassAvg 341.55 MassMono 341.238850 Origin C Source natural TermSpec none MOD:00440 MOD:00905 PSI-MOD MOD:01685 alpha-amino palmitoylated residue A protein modification that effectively replaces a residue alpha-amino group with a alpha-palmitoylamino group. 47#N-term UniMod PSI-MOD-slim N2PamRes PSI-MOD-label Palmitoyl PSI-MS-label Palmitoylation UniMod-description DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 S 0 DiffMono 238.229666 Formula none MassAvg none MassMono none Origin X Source natural TermSpec N-term MOD:00651 MOD:01696 PSI-MOD MOD:01686 alpha-amino dimethylated residue A protein modification that effectively replaces two alpha amino hydrogen atoms with two methyl group. 36#N-term UniMod For alpha-amino acids, both N-alpha-monomethylation and complete N-alpha protonation and trimethylation have been observed, but incomplete dimethylation has not been reported as a natural process. For N-terminal proline residues, dimethylation can only be effectively accomplished with a protonated imino group, whereas this process accounts only for dimethylation and not protonation. See MOD:00889. di-Methylation UniMod-description Dimethyl PSI-MS-label N2Me2Res PSI-MOD-label ntermpepdimethyl OMSSA-label DiffAvg 28.05 DiffFormula C 2 H 4 DiffMono 28.031300 Formula none MassAvg none MassMono none Origin X Source none TermSpec N-term MOD:00429 MOD:01460 PSI-MOD MOD:01687 alpha-amino trimethylated residue A protein modification that effectively replaces an alpha-aminium group with a trimethylaminium group. 37#N-term UniMod For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Res process (MOD:01698) accounts for both protonation and trimethylation. PSI-MOD-slim N2Me3Res PSI-MOD-label ntermtrimethyl OMSSA-label tri-Methylation UniMod-description Trimethyl PSI-MS-label DiffAvg 42.08 DiffFormula C 3 H 6 N 0 O 0 DiffMono 42.046402 FormalCharge 1+ Formula none MassAvg none MassMono none Origin X Source natural TermSpec N-term MOD:00430 MOD:01460 derives_from MOD:017000 PSI-MOD MOD:01688 3-hydroxy-L-asparagine A protein modification that effectively converts an L-asparagine residue to one of the diastereomeric 3-hydroxy-L-asparagine residues. 35#N UniMod PSI-MOD-slim 3HyAsn PSI-MOD-label hydroxylationn OMSSA-label monohydroxylated asparagine PSI-MOD-alternate Oxidation PSI-MS-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 4 H 6 N 2 O 3 MassAvg 130.10 MassMono 130.037842 Origin N Source natural TermSpec none MOD:00425 MOD:00903 PSI-MOD MOD:01689 alpha-carboxyl methylated residue A protein modification that effectively converts a carboxyl-terminal residue to an alpha-carboxyl (1-carboxyl) methyl ester. 34#C-term UniMod PSI-MOD-slim C1OMeRes PSI-MOD-label ctermpepmeester OMSSA-label ctermpepmethyl OMSSA-label Methyl PSI-MS-label Methyl UniMod-alternate DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 S 0 DiffMono 14.015650 Formula none MassAvg none MassMono none Origin X Source natural TermSpec C-term MOD:00393 PSI-MOD MOD:01690 N-[(12R)-12-hydroxymyristoyl]-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-[(12R)-12-hydroxymyristoyl]-L-cysteine. AA0516 RESID 2-[(12R)-12-hydroxytetradecanoyl]amino-3-sulfanylpropanoic acid RESID-systematic LIPID N-[(12R)-12-hydroxymyristoyl]cysteine UniProt-feature N-[(12R)-12-hydroxymyristoyl]-L-cysteine RESID-name N-[(12R)-12-hydroxytetradecanoyl]cysteine RESID-alternate DiffAvg 226.36 DiffFormula C 14 H 26 N 0 O 2 S 0 DiffMono 226.193280 Formula C 17 H 32 N 1 O 3 S 1 MassAvg 330.51 MassMono 330.210290 Origin C Source natural TermSpec N-term MOD:00905 MOD:01696 PSI-MOD MOD:01691 N-(12-ketomyristoyl)-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-(12-ketomyristoyl)-L-cysteine. 19053188 PubMed AA0517 RESID 2-(12-oxotetradecanoyl)amino-3-sulfanylpropanoic acid RESID-systematic LIPID N-(12-oxomyristoyl)cysteine UniProt-feature N-(12-ketomyristoyl)-L-cysteine RESID-name N-(12-oxotetradecanoyl)cysteine RESID-alternate DiffAvg 224.34 DiffFormula C 14 H 24 N 0 O 2 S 0 DiffMono 224.177630 Formula C 17 H 30 N 1 O 3 S 1 MassAvg 328.49 MassMono 328.194640 Origin C Source natural TermSpec N-term MOD:00905 MOD:01696 PSI-MOD MOD:01692 glutamyl semialdehyde (Glu) A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl semialdehyde. 18688235 PubMed 743268 PubMed Deoxy PSI-MS-label gamma-glutamyl semialdehyde PSI-MOD-alternate glutamyl 5-semialdehyde PSI-MOD-alternate glutamyl aldehyde PSI-MOD-alternate DiffAvg -16.00 DiffFormula C 0 H 0 N 0 O -1 DiffMono -15.994915 Formula C 5 H 7 N 1 O 2 MassAvg 113.12 MassMono 113.047678 Origin E Source artifact TermSpec none MOD:00906 MOD:01161 MOD:01440 PSI-MOD MOD:01693 alpha-amino pyridylacetylated residue A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a (pyrid-3-yl)acetyl group. 9276974 PubMed 25#N-term UniMod Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. ntermpeppyridyl OMSSA-label Pyridylacetyl PSI-MS-label pyridylacetyl UniMod-description DiffAvg 119.12 DiffFormula C 7 H 5 N 1 O 1 DiffMono 119.037114 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00418 MOD:01696 PSI-MOD MOD:01694 S-(coelenterazin-3a-yl)-L-cysteine A protein modification that effectively results from forming an adduct between an L-cysteine residue and the bioluminescent compound didehydrocoelenterazine to form S-(coelenterazin-3a-yl)-L-cysteine. 2311 ChEBI 18997450 PubMed AA0526 RESID (2R)-2-amino-3-([(4-hydroxyphenyl)(8-benzyl-3-oxo-6-[4-hydroxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)methyl]sulfanyl)propanoic acid RESID-systematic dehydrocoelenterazine cysteine adduct RESID-alternate MOD_RES S-(coelenterazin-3a-yl)cysteine UniProt-feature S-(coelenterazin-3a-yl)-L-cysteine RESID-name symplectin chromophore RESID-alternate DiffAvg 421.46 DiffFormula C 26 H 19 N 3 O 3 S 0 DiffMono 421.142641 Formula C 29 H 24 N 4 O 4 S 1 MassAvg 524.60 MassMono 524.151826 Origin C Source natural TermSpec none MOD:00905 PSI-MOD MOD:01695 alpha-amino 3-(carboxamidomethylthio)propanoylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 3-(carboxamidomethylthio)propanoyl group. 15121203 PubMed 293#N-term UniMod 3-(carbamidomethylthio)propanoyl UniMod-description CAMthiopropanoyl PSI-MS-label DiffAvg 145.18 DiffFormula C 5 H 7 N 1 O 2 S 1 DiffMono 145.019749 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00612 MOD:01696 PSI-MOD MOD:01696 alpha-amino acylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group. 18688235 PubMed PSI-MOD-slim Origin X Source natural TermSpec N-term MOD:00670 PSI-MOD MOD:01697 alpha-amino 4-(2-aminoethyl)benzenesulfonylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 4-(2-aminoethyl)benzenesulfonyl group. 235 DeltaMass 8597590 PubMed 276#N-term UniMod See the comment for MOD:00596 [JSG]. AEBS PSI-MS-label Aminoethylbenzenesulfonylation UniMod-description DiffAvg 183.23 DiffFormula C 8 H 9 N 1 O 2 S 1 DiffMono 183.035400 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00596 PSI-MOD MOD:01698 alpha-amino trimethylated protonated-residue A protein modification that effectively replaces an amino group with a trimethylaminium group. 18688235 PubMed PSI-MOD-slim N2Me3+Res PSI-MOD-label tri-Methylation UniMod-description Trimethyl PSI-MS-label DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 S 0 DiffMono 43.054227 FormalCharge 1+ Formula none MassAvg none MassMono none Origin X Source natural TermSpec N-term MOD:00711 MOD:01460 PSI-MOD MOD:01699 protonated residue A protein modification that effectively adds a hydrogen cation, a proton, forming a cationic residue. 18688235 PubMed PSI-MOD-slim H+NRes PSI-MOD-label DiffAvg 1.01 DiffFormula C 0 H 1 N 0 O 0 DiffMono 1.007276 FormalCharge 1+ Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:01156 PSI-MOD MOD:01700 alpha-amino protonated residue A protein modification that effectively adds a proton to a residue alpha-amnino or alpha-imino group forming an alpha-aminium or alpha-iminium group, respectively. 18688235 PubMed PSI-MOD-slim N2H+NRes PSI-MOD-label DiffAvg 1.01 DiffFormula C 0 H 1 N 0 O 0 DiffMono 1.007276 FormalCharge 1+ Formula none MassAvg none MassMono none Origin X Source natural TermSpec N-term MOD:01699 PSI-MOD MOD:01701 deprotonated residue A protein modification that effectively removes a hydrogen cation, a proton, forming an anionic residue. 18688235 PubMed PSI-MOD-slim H-NRes PSI-MOD-label DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007276 FormalCharge 1- Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:01156 PSI-MOD MOD:01702 alpha-carboxyl deprotonated residue A protein modification that effectively removes a proton from a residue 1-carboxyl group (referred to as the alpha-carboxyl), forming a carboxylate anion. 18688235 PubMed PSI-MOD-slim C1H-NRes PSI-MOD-label DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 DiffMono -1.007276 FormalCharge 1- Formula none MassAvg none MassMono none Origin X Source natural TermSpec C-term MOD:01701 PSI-MOD MOD:01703 dehydrobutyrine A protein modification that effectively converts a source amino acid residue to dehydrobutyrine. 18688235 PubMed PSI-MOD-slim beta-elim-t OMSSA-label Dehydrated PSI-MS-label Dehydrated UniMod-interim Dehydration UniMod-description dehydro OMSSA-label Dehydroamino butyric acid DeltaMass-label dHAbu PSI-MOD-label phospholosst OMSSA-label DiffAvg none DiffFormula none DiffMono none Formula C 4 H 5 N 1 O 1 MassAvg 83.09 MassMono 83.037114 Origin X Source none TermSpec none MOD:00859 PSI-MOD MOD:01704 dehydrobutyrine (Met) A protein modification that effectively converts an L-methionine residue to dehydrobutyrine, by neutral loss of methyl sulfide. 18688235 PubMed It is expected that this neutral loss will produce a mix of (E)- and (Z)-isomers [JSG]. PSI-MOD-slim dHAbu(Met) PSI-MOD-label DiffAvg -48.10 DiffFormula C -1 H -4 N 0 O 0 S -1 DiffMono -48.003371 Formula C 4 H 5 N 1 O 1 MassAvg 83.09 MassMono 83.037114 Origin M Source artifact TermSpec none MOD:00913 MOD:01703 PSI-MOD MOD:01705 isotope tagged reagent acylated residue A protein modification that effectively replaces a residue hydrogen with an isotope tagged reagent acyl group. 18688235 PubMed PSI-MOD-slim Origin X Source artifact TermSpec none MOD:00649 PSI-MOD MOD:01706 isotope tagged reagent N-acylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group. 18688235 PubMed PSI-MOD-slim Origin X Source artifact TermSpec none MOD:00670 PSI-MOD MOD:01707 isotope tagged reagent O-acylated residue A protein modification that effectively replaces a residue hydroxyl group with an isotope tagged reagent acyloxy group. 18688235 PubMed Origin X Source artifact TermSpec none MOD:00671 PSI-MOD MOD:01708 isotope tagged reagent alpha-amino acylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group. 18688235 PubMed PSI-MOD-slim Origin X Source artifact TermSpec N-term MOD:01696 MOD:01705 MOD:01706 PSI-MOD MOD:01709 iTRAQ4plex reporter+balance reagent N-acylated residue A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01706 PSI-MOD MOD:01710 iTRAQ8plex reporter+balance reagent N-acylated residue A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01706 PSI-MOD MOD:01711 iTRAQ4plex reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. 214#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01708 MOD:01709 PSI-MOD MOD:01712 iTRAQ8plex reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. 214#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01708 MOD:01710 PSI-MOD MOD:01713 iTRAQ4plex reporter+balance reagent O-acylated residue A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance acyloxy groups. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01707 PSI-MOD MOD:01714 iTRAQ8plex reporter+balance reagent O-acylated residue A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance acyloxy groups. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01707 PSI-MOD MOD:01715 TMT6plex reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with a Proteome Sciences TMT6plex reporter+balance group. 214 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 MOD:01428 MOD:01429 MOD:01705 PSI-MOD MOD:01716 TMT6plex reporter fragment The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue. 18688235 PubMed PSI-MOD-slim 2,6-dimethyl-1-methylidenepiperidinium PSI-MOD-alternate cysTMT6plex reporter fragment PSI-MOD-alternate MOD:01520 derives_from MOD:017150 derives_from MOD:018210 PSI-MOD MOD:01717 TMT6plex reporter+balance reagent N-acylated residue A protein modification that effectively replaces a residue amino- or imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01706 PSI-MOD MOD:01718 TMT6plex reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group. 214#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01708 MOD:01717 PSI-MOD MOD:01719 TMT6plex reporter+balance reagent O-acylated residue A protein modification that effectively replaces a residue hydroxyl with one of the Proteome Sciences TMT6plex reagent reporter+balance acyloxy groups. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01707 PSI-MOD MOD:01720 TMT6plex-126 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-126 reporter+balance group. 737 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01715 PSI-MOD MOD:01721 TMT6plex-126 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-126 reporter+balance group. 737#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01718 MOD:01720 PSI-MOD MOD:01722 TMT6plex-126 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. 737#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg 357.26 MassMono 357.257895 Origin K Source artifact TermSpec none MOD:01717 MOD:01720 MOD:01875 PSI-MOD MOD:01723 TMT6plex-126 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. 737#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg 392.23 MassMono 392.226261 Origin Y Source artifact TermSpec none MOD:00919 MOD:01719 MOD:01720 PSI-MOD MOD:01724 TMT6plex-126 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg 366.22 MassMono 366.221844 Origin H Source artifact TermSpec none MOD:00909 MOD:01717 MOD:01720 PSI-MOD MOD:01725 TMT6plex-126 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg 316.19 MassMono 316.194961 Origin S Source artifact TermSpec none MOD:00916 MOD:01719 MOD:01720 PSI-MOD MOD:01726 TMT6plex-126 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg 330.21 MassMono 330.210611 Origin T Source artifact TermSpec none MOD:00917 MOD:01719 MOD:01720 PSI-MOD MOD:01727 TMT6plex-126 reporter fragment The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue. 18688235 PubMed PSI-MOD-slim 2,6-dimethyl-1-methylidenepiperidinium PSI-MOD-alternate cysTMT6plex-126 reporter fragment PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 8 H 16 (14)N 1 MassAvg 126.13 MassMono 126.127726 Origin X Source artifact TermSpec none MOD:01716 derives_from MOD:017200 derives_from MOD:018220 derives_from MOD:018230 PSI-MOD MOD:01728 TMT6plex-127 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-127 reporter+balance group. 737 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01715 PSI-MOD MOD:01729 TMT6plex-127 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-127 reporter+balance group. 737#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01718 MOD:01728 PSI-MOD MOD:01730 TMT6plex-127 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. 737#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg 357.26 MassMono 357.257895 Origin K Source artifact TermSpec none MOD:01717 MOD:01728 MOD:01875 PSI-MOD MOD:01731 TMT6plex-127 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. 737#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 MassAvg 229.16 MassMono 229.162932 Origin Y Source artifact TermSpec none MOD:00919 MOD:01719 MOD:01728 PSI-MOD MOD:01732 TMT6plex-127 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg 366.22 MassMono 366.221844 Origin H Source artifact TermSpec none MOD:00909 MOD:01717 MOD:01728 PSI-MOD MOD:01733 TMT6plex-127 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg 316.19 MassMono 316.194961 Origin S Source artifact TermSpec none MOD:00916 MOD:01719 MOD:01728 PSI-MOD MOD:01734 TMT6plex-127 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg 330.21 MassMono 330.210611 Origin T Source artifact TermSpec none MOD:00917 MOD:01719 MOD:01728 PSI-MOD MOD:01735 TMT6plex-127 reporter fragment The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-127 reagent acylated residue. 18688235 PubMed PSI-MOD-slim 2,6-dimethyl-1-methylidenepiperidinium PSI-MOD-alternate cysTMT6plex-127 reporter fragment PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 7 (13)C 1 H 16 (14)N 1 MassAvg 127.13 MassMono 127.131081 Origin X Source artifact TermSpec none MOD:01716 derives_from MOD:017280 derives_from MOD:018240 PSI-MOD MOD:01736 TMT6plex-128 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-128 reporter+balance group. 737 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01715 PSI-MOD MOD:01737 TMT6plex-128 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-128 reporter+balance group. 737#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01718 MOD:01736 PSI-MOD MOD:01738 TMT6plex-128 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. 737#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg 357.26 MassMono 357.257895 Origin K Source artifact TermSpec none MOD:01717 MOD:01736 MOD:01875 PSI-MOD MOD:01739 TMT6plex-128 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. 737#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg 392.23 MassMono 392.226261 Origin Y Source artifact TermSpec none MOD:00919 MOD:01719 MOD:01736 PSI-MOD MOD:01740 TMT6plex-128 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg 366.22 MassMono 366.221844 Origin H Source artifact TermSpec none MOD:00909 MOD:01717 MOD:01736 PSI-MOD MOD:01741 TMT6plex-128 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg 316.19 MassMono 316.194961 Origin S Source artifact TermSpec none MOD:00916 MOD:01719 MOD:01736 PSI-MOD MOD:01742 TMT6plex-128 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg 330.21 MassMono 330.210611 Origin T Source artifact TermSpec none MOD:00917 MOD:01719 MOD:01736 PSI-MOD MOD:01743 TMT6plex-128 reporter fragment The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-128 reagent acylated residue. 18688235 PubMed PSI-MOD-slim 2,6-dimethyl-1-methylidenepiperidinium PSI-MOD-alternate cysTMT6plex-128 reporter fragment PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 6 (13)C 2 H 16 (14)N 1 MassAvg 128.13 MassMono 128.134436 Origin X Source artifact TermSpec none MOD:01716 derives_from MOD:017360 derives_from MOD:018250 PSI-MOD MOD:01744 TMT6plex-129 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-129 reporter+balance group. 737 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01715 PSI-MOD MOD:01745 TMT6plex-129 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-129 reporter+balance group. 737#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01718 MOD:01744 PSI-MOD MOD:01746 TMT6plex-129 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. 737#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg 357.26 MassMono 357.257895 Origin K Source artifact TermSpec none MOD:01717 MOD:01744 MOD:01875 PSI-MOD MOD:01747 TMT6plex-129 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. 737#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg 392.23 MassMono 392.226261 Origin Y Source artifact TermSpec none MOD:00919 MOD:01719 MOD:01744 PSI-MOD MOD:01748 TMT6plex-129 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg 366.22 MassMono 366.221844 Origin H Source artifact TermSpec none MOD:00909 MOD:01717 MOD:01744 PSI-MOD MOD:01749 TMT6plex-129 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg 316.19 MassMono 316.194961 Origin S Source artifact TermSpec none MOD:00916 MOD:01719 MOD:01744 PSI-MOD MOD:01750 TMT6plex-129 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg 330.21 MassMono 330.210611 Origin T Source artifact TermSpec none MOD:00917 MOD:01719 MOD:01744 PSI-MOD MOD:01751 TMT6plex-129 reporter fragment The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-129 reagent acylated residue. 18688235 PubMed PSI-MOD-slim 2,6-dimethyl-1-methylidenepiperidinium PSI-MOD-alternate cysTMT6plex-129 reporter fragment PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 5 (13)C 3 H 16 (14)N 1 MassAvg 129.14 MassMono 129.137790 Origin X Source artifact TermSpec none MOD:01716 derives_from MOD:017440 derives_from MOD:018260 PSI-MOD MOD:01752 TMT6plex-130 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-130 reporter+balance group. 737 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01715 derives_from MOD:018270 PSI-MOD MOD:01753 TMT6plex-130 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-130 reporter+balance group. 737#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01718 MOD:01752 PSI-MOD MOD:01754 TMT6plex-130 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. 737#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg 357.26 MassMono 357.257895 Origin K Source artifact TermSpec none MOD:01717 MOD:01752 MOD:01875 PSI-MOD MOD:01755 TMT6plex-130 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. 737#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg 392.23 MassMono 392.226261 Origin Y Source artifact TermSpec none MOD:00919 MOD:01719 MOD:01752 PSI-MOD MOD:01756 TMT6plex-130 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg 366.22 MassMono 366.221844 Origin H Source artifact TermSpec none MOD:00909 MOD:01717 MOD:01752 PSI-MOD MOD:01757 TMT6plex-130 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg 316.19 MassMono 316.194961 Origin S Source artifact TermSpec none MOD:00916 MOD:01719 MOD:01752 PSI-MOD MOD:01758 TMT6plex-130 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg 330.21 MassMono 330.210611 Origin T Source artifact TermSpec none MOD:00917 MOD:01719 MOD:01752 PSI-MOD MOD:01759 TMT6plex-130 reporter fragment The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-130 reagent acylated residue. 18688235 PubMed PSI-MOD-slim 2,6-dimethyl-1-methylidenepiperidinium PSI-MOD-alternate cysTMT6plex-130 reporter fragment PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 4 (13)C 4 H 16 (14)N 1 MassAvg 130.14 MassMono 130.141145 Origin X Source artifact TermSpec none MOD:01716 derives_from MOD:017520 PSI-MOD MOD:01760 TMT6plex-131 reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-131 reporter+balance group. 737 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate cysTMT6plex-131 reporter fragment PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01715 derives_from MOD:018280 PSI-MOD MOD:01761 TMT6plex-131 reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-131 reporter+balance group. 737#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01718 MOD:01760 PSI-MOD MOD:01762 TMT6plex-131 reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. 737#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg 357.26 MassMono 357.257895 Origin K Source artifact TermSpec none MOD:01717 MOD:01760 MOD:01875 PSI-MOD MOD:01763 TMT6plex-131 reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. 737#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg 392.23 MassMono 392.226261 Origin Y Source artifact TermSpec none MOD:00919 MOD:01719 MOD:01760 PSI-MOD MOD:01764 TMT6plex-131 reporter+balance reagent N'-acylated histidine A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg 366.22 MassMono 366.221844 Origin H Source artifact TermSpec none MOD:00909 MOD:01717 MOD:01760 PSI-MOD MOD:01765 TMT6plex-131 reporter+balance reagent O3-acylated serine A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg 316.19 MassMono 316.194961 Origin S Source artifact TermSpec none MOD:00916 MOD:01719 MOD:01760 PSI-MOD MOD:01766 TMT6plex-131 reporter+balance reagent O3-acylated threonine A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg 229.16 DiffFormula (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono 229.162932 Formula (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg 330.21 MassMono 330.210611 Origin T Source artifact TermSpec none MOD:00917 MOD:01719 MOD:01760 PSI-MOD MOD:01767 TMT6plex-131 reporter fragment The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-131 reagent acylated residue. 18688235 PubMed 2,6-dimethyl-1-methylidenepiperidinium PSI-MOD-alternate Sixplex Tandem Mass Tag(TM) UniMod-description TMT6plex UniMod-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 4 (13)C 4 H 16 (15)N 1 MassAvg 131.14 MassMono 131.138180 Origin X Source artifact TermSpec none MOD:01716 derives_from MOD:017600 PSI-MOD MOD:01768 O-palmitoleylated residue A protein modification that effectively replaces a residue hydroxyl group with a palmitoleyloxy group. 18688235 PubMed PSI-MOD-slim DiffAvg 236.40 DiffFormula C 16 H 28 N 0 O 1 DiffMono 236.214016 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00671 MOD:01423 PSI-MOD MOD:01769 O-palmitoleyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-palmitoleyl-L-threonine. 6642431 PubMed 8413602 PubMed AA0079#var RESID 431#T UniMod PSI-MOD-slim (2S,3R)-2-amino-3-((Z)-9-hexadecenoyloxy)butanoic acid PSI-MOD-alternate L-threonine cis-9-hexadecenoate ester PSI-MOD-alternate mod188 OMSSA-label O-palmitoleylated L-threonine PSI-MOD-alternate O3-palmitoleyl-threonine PSI-MOD-alternate Palmitoleyl PSI-MS-label palmitoleyl UniMod-description DiffAvg 236.40 DiffFormula C 16 H 28 N 0 O 1 DiffMono 236.214016 Formula C 20 H 35 N 1 O 3 MassAvg 337.50 MassMono 337.261694 Origin T Source natural TermSpec none MOD:00917 MOD:01768 PSI-MOD MOD:01770 O-palmitoyl-L-threonine amide A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine amide. 8413602 PubMed AA0079#var RESID AA0097#var RESID (2S,3R)-2-amino-3-(hexadecanoyloxy)butanamide PSI-MOD-alternate OPamThrN PSI-MOD-label DiffAvg 254.44 DiffFormula C 16 H 32 N 1 O 1 DiffMono 254.248390 Formula C 20 H 39 N 2 O 3 MassAvg 355.54 MassMono 355.296068 Origin T Source natural TermSpec C-term MOD:00917 has_functional_parent MOD:000880 has_functional_parent MOD:001060 PSI-MOD MOD:01771 farnesyl reporter fragment The farnesyl cation protein modification reporter fragment produced by fragmentation of some farnesyl modified residues. 15609361 PubMed 18688235 PubMed PSI-MOD-slim (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylium PSI-MOD-alternate Farn+ PSI-MOD-label farnesyl cation PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula C 15 H 25 MassAvg 205.36 MassMono 205.195077 Origin X Source natural TermSpec none MOD:01520 derives_from MOD:004370 PSI-MOD MOD:01772 palmityl reporter fragment The palmityl cation protein modification reporter fragment produced by fragmentation of some palmitoyl modified residues. 18688235 PubMed 8413602 PubMed PSI-MOD-slim palmityl cation PSI-MS-label Pam+ PSI-MOD-label DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula C 16 H 31 O 1 MassAvg 239.42 MassMono 239.236942 Origin X Source natural TermSpec none MOD:01520 derives_from MOD:004400 PSI-MOD MOD:01773 N6,N6,N6-trimethyl-L-lysine with neutral loss of trimethylamine Covalent modification of a trimethyllysine residue with secondary loss of a neutral trimethylamine molecular fragment. 17205979 PubMed 18688235 PubMed PSI-MOD-slim dMe3N6Me3+Lys PSI-MOD-label DiffAvg -59.11 DiffFormula C -3 H -9 N -1 O 0 DiffMono -59.074048 FormalCharge 1+ Formula C 6 H 10 N 1 O 1 MassAvg 112.15 MassMono 112.075690 Origin MOD:00083 Source artifact TermSpec none MOD:00431 MOD:00912 derives_from MOD:000830 PSI-MOD MOD:01774 N6-octanoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-octanoyl-L-lysine. 12591875 PubMed 2215217 PubMed AA0527 RESID PSI-MOD-slim (2S)-2-amino-6-(octanoylamino)hexanoic acid RESID-systematic epsilon-octanoyllysine RESID-alternate N(zeta)-octanoyllysine RESID-alternate N6-(1-oxooctyl)-L-lysine RESID-alternate N6-octanoyl-L-lysine RESID-name DiffAvg 126.20 DiffFormula C 8 H 14 N 0 O 1 DiffMono 126.104465 Formula C 14 H 26 N 2 O 2 MassAvg 254.37 MassMono 254.199428 Origin K Source natural TermSpec none MOD:00666 MOD:01875 PSI-MOD MOD:01775 5-glutamyl serotonin A protein modification that effectively converts an L-glutamine residue to 5-glutamyl serotonin. 11805836 PubMed 14697203 PubMed AA0528 RESID (2S)-2-amino-5-([2-(5-hydroxy-1H-indol-3-yl)ethyl]amino)-5-oxopentanoic acid RESID-systematic 5-glutamyl serotonin RESID-name N2-(gamma-glutamyl)-5-hydoxytryptamine RESID-alternate N5-[2-(5-hydroxy-3-indolyl)ethyl]glutamine RESID-alternate DiffAvg 159.19 DiffFormula C 10 H 9 N 1 O 1 DiffMono 159.068414 Formula C 15 H 17 N 3 O 3 MassAvg 287.32 MassMono 287.126991 Origin Q Source natural TermSpec none MOD:00907 PSI-MOD MOD:01776 S-methylthiocarbonylaminoethylcysteine (Cys) A protein modification that effectively converts an L-cysteine residue to S-methylthiocarbonylaminoethylcysteine. 18688235 PubMed 20608637 PubMed This modified residue is a chemical analog of N6-acetyl-L-lysine produced from L-cysteine by methylthiocarbonylaziridine (MTCA, S-methyl aziridine-1-carbothioate). (2R)-2-amino-3-([2-([(methylsulfanyl)carbonyl]amino)ethyl]sulfanyl)propanoic acid PSI-MOD-alternate L-cysteine N-(methylthiocarbonyl)aziridine adduct PSI-MOD-alternate MTCTK PSI-MOD-alternate N6-methylthiocarbonyl-4-thialysine PSI-MOD-alternate S-[2-([(methylthio)carbonyl]amino)ethyl]-L-cysteine PSI-MOD-alternate DiffAvg 117.17 DiffFormula C 4 H 7 N 1 O 1 S 1 DiffMono 117.024835 Formula C 7 H 12 N 2 O 2 S 2 MassAvg 220.31 MassMono 220.034020 Origin C Source artifact TermSpec none MOD:00848 MOD:00905 PSI-MOD MOD:01777 S-(glycyl)-L-cysteine (Gly) A protein modification that effectively converts a C-terminal glycine residue to S-(glycyl)-L-cysteine by forming a thioester bond with a free L-cysteine. 22050 ChEBI 17726030 PubMed 18359941 PubMed 18771296 PubMed 18799456 PubMed 18842002 PubMed 3306404 PubMed AA0206 RESID This is not the cross-linking of two peptides, but the modification of a C-terminal glycine by formation of an thioester bond with a free cysteine. For the cross-linking of two peptide see MOD:00211 [JSG]. (2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid RESID-systematic 1-(cystein-S-yl)-glycinate RESID-alternate glycine cysteine thioester RESID-alternate MOD_RES CysO-cysteine adduct UniProt-feature S-(2-amino-1-oxoethyl)cysteine RESID-alternate S-(glycyl)-L-cysteine RESID-name DiffAvg 103.14 DiffFormula C 3 H 5 N 1 O 1 S 1 DiffMono 103.009185 Formula C 5 H 9 N 2 O 3 S 1 MassAvg 177.20 MassMono 177.033388 Origin G Source natural TermSpec C-term MOD:00908 PSI-MOD MOD:01778 N-(glycyl)-L-cysteine A protein modification that effectively converts a C-terminal glycine residue to N-(glycyl)-L-cysteine by forming a peptide bond with a free L-cysteine. 18771296 PubMed 18799456 PubMed 18842002 PubMed AA0529 RESID (2R)-2-[(aminoacetyl)amino]-3-sulfanylpropanoic acid RESID-systematic MOD_RES CysO-cysteine adduct UniProt-feature N-(2-amino-1-oxoethyl)cysteine RESID-alternate N-(glycyl)-L-cysteine RESID-name DiffAvg 103.14 DiffFormula C 3 H 5 N 1 O 1 S 1 DiffMono 103.009185 Formula C 5 H 9 N 2 O 3 S 1 MassAvg 177.20 MassMono 177.033388 Origin G Source hypothetical TermSpec C-term MOD:00908 PSI-MOD MOD:01779 N6-(L-lysyl)-L-lysine A protein modification that effectively converts an L-lysine residue to N6-(L-lysyl)-L-lysine by formation of an isopeptide bond between the carboxyl group of a free lysine and the N6-amino group of the peptidyl L-lysine. 18201202 PubMed 20729861 PubMed AA0530 RESID This is not the cross-linking of two peptides, but the modification of a peptidyl lysine by formation of an isopeptide bond with a free lysine [JSG]. (2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid RESID-systematic N6-(alpha-lysyl)-lysine RESID-alternate N6-(L-lysyl)-L-lysine RESID-name DiffAvg 128.18 DiffFormula C 6 H 12 N 2 O 1 DiffMono 128.094963 Formula C 12 H 24 N 4 O 2 MassAvg 256.35 MassMono 256.189926 Origin K Source natural TermSpec none MOD:01875 PSI-MOD MOD:01780 N6-(beta-lysyl)-L-5-hydroxylysine A protein modification that effectively converts an L-lysine residue to N6-(beta-lysyl)-L-5-hydroxylysine by formation of an isopeptide bond between the carboxyl group of a free beta-lysine and the N6-amino group of a peptidyl L-lysine. 18201202 PubMed 20729861 PubMed AA0531 RESID (2S)-2-amino-6-([(3R)-3,6-diaminohexanoyl]amino)-5-hydroxyhexanoic acid RESID-systematic 5-hydroxy-N6-(beta-lysyl)-L-lysine RESID-name 5-hydroxy-N6-[(3R)-beta-lysyl]lysine RESID-alternate EF-P lysine derivative RESID-alternate lysyl spermidine derivative [misidentification] RESID-alternate MOD_RES N6-(3,6-diaminohexanoyl)-5-hydroxylysine UniProt-feature N6-[(3R)-3,6-diaminohexanoyl]-L-5-hydroxylysine RESID-alternate DiffAvg 144.17 DiffFormula C 6 H 12 N 2 O 2 DiffMono 144.089878 Formula C 12 H 24 N 4 O 3 MassAvg 272.35 MassMono 272.184841 Origin K Source hypothetical TermSpec none MOD:00037 MOD:01875 PSI-MOD MOD:01781 N6-butanoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-butanoyl-L-lysine. 17267393 PubMed 20715035 PubMed AA0532 RESID 1289 UniMod The binding of histone peptides with butanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. (2S)-2-amino-6-(butanoylamino)hexanoic acid RESID-systematic (2S)-2-azanyl-6-(butanoylamino)hexanoic acid RESID-alternate 2-amino-6-butyrylaminocaproic acid RESID-alternate epsilon-butanoyl-L-lysine RESID-alternate epsilon-butyryl-L-lysine RESID-alternate N(zeta)-butanoyllysine RESID-alternate N6-(1-oxobutyl)-L-lysine RESID-alternate N6-butanoyl-L-lysine RESID-name N6-butyryllysine RESID-alternate DiffAvg 70.09 DiffFormula C 4 H 6 N 0 O 1 DiffMono 70.041865 Formula C 10 H 18 N 2 O 2 MassAvg 198.27 MassMono 198.136828 Origin K Source hypothetical TermSpec none MOD:01875 MOD:01997 PSI-MOD MOD:01782 N-methyl-L-serine A protein modification that effectively converts an L-serine residue to N-methyl-L-serine. 20668449 PubMed AA0533 RESID PSI-MOD-slim (2S)-3-hydroxy-2-(methylamino)propanoic acid RESID-systematic MOD_RES N-methylserine UniProt-feature N-methyl-L-serine RESID-name N-methylserine RESID-alternate DiffAvg 14.03 DiffFormula C 1 H 2 N 0 O 0 DiffMono 14.015650 Formula C 4 H 7 N 1 O 2 MassAvg 101.10 MassMono 101.047678 Origin S Source natural TermSpec none MOD:01680 MOD:01800 PSI-MOD MOD:01783 N,N-dimethyl-L-serine A protein modification that effectively converts an L-serine residue to N,N-dimethyl-L-serine. 20668449 PubMed AA0534 RESID (2S)-2-(dimethylamino)propanoic acid RESID-systematic MOD_RES N,N-dimethylserine UniProt-feature N,N-dimethyl-L-serine RESID-name N,N-dimethylserine RESID-alternate DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 5 H 10 N 1 O 2 MassAvg 116.14 MassMono 116.071154 Origin S Source natural TermSpec N-term MOD:01686 MOD:01800 PSI-MOD MOD:01784 N,N,N-trimethyl-L-serine A protein modification that effectively converts an L-serine residue to N,N,N-trimethyl-L-serine. 20668449 PubMed 3979397 PubMed AA0535 RESID PSI-MOD-slim (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanaminium RESID-systematic (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanazanium RESID-alternate (2S)-2-trimethylammonio-3-hydroxypropanoic acid RESID-alternate MOD_RES N,N,N-trimethylserine UniProt-feature N,N,N-trimethyl-L-serine RESID-name N,N,N-trimethylserine cation RESID-alternate N,N,N-trimethylserinium RESID-alternate DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 DiffMono 43.054227 FormalCharge 1+ Formula C 6 H 13 N 1 O 2 MassAvg 131.17 MassMono 131.094080 Origin S Source natural TermSpec N-term MOD:01698 MOD:01800 PSI-MOD MOD:01785 O-(L-isoglutamyl)-L-threonine (active site intermediate) A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia. 8706862 PubMed AA0536#THR RESID This is not an ester cross-link of peptides [JSG]. (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid RESID-systematic (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid RESID-alternate 5-(threon-O3-yl)glutamate RESID-alternate O(beta)-(gamma-glutamyl)threonine RESID-alternate O-(L-isoglutamyl)-L-threonine RESID-name O3-(isoglutamyl)threonine RESID-alternate DiffAvg 129.12 DiffFormula C 5 H 7 N 1 O 3 DiffMono 129.042593 Formula C 9 H 14 N 2 O 5 MassAvg 230.22 MassMono 230.090272 Origin T Source hypothetical TermSpec none MOD:00671 MOD:01979 PSI-MOD MOD:01786 3'-nitro-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to 3'-nitro-L-tyrosine. 44454 ChEBI 16944230 PubMed 5339594 PubMed AA0537 RESID PSI-MOD-slim (2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid RESID-systematic 3'-nitro-L-tyrosine RESID-name 3-nitro-L-tyrosine RESID-alternate 3-nitrotyrosine RESID-alternate m-nitrotyrosine RESID-alternate meta-nitrotyrosine RESID-alternate MOD_RES 3'-Nitrotyrosine UniProt-feature DiffAvg 45.00 DiffFormula C 0 H -1 N 1 O 2 DiffMono 44.985078 Formula C 9 H 8 N 2 O 4 MassAvg 208.17 MassMono 208.048407 Origin Y Source natural TermSpec none MOD:01352 PSI-MOD MOD:01787 5'-(L-tyros-5'-yl)amino-L-tyrosine A protein modification that effectively cross-links two L-tyrosine residues through their 5' positions by amine nitrogen to form 5'-(L-tyros-5'-yl)amino-L-tyrosine. 18781570 PubMed AA0459 RESID Cross-link 2. (2S,2'S)-3,3'-[iminobis(4-hydroxybenzene-3,1-diyl)]bis(2-aminopropanoic acid) RESID-systematic 5'-(L-tyros-5'-yl)amino-L-tyrosine RESID-name 5'-[(tyros-5'-yl)amino]tyrosine RESID-alternate 5'-tyrosyl-5'-aminotyrosine RESID-alternate bis(LTQ) linkage RESID-alternate CROSSLNK 5'-tyrosyl-5'-aminotyrosine (Tyr-Tyr) (interchain) UniProt-feature DiffAvg 13.00 DiffFormula C 0 H -1 N 1 O 0 DiffMono 12.995249 Formula C 18 H 17 N 3 O 4 MassAvg 339.35 MassMono 339.121906 Origin Y, Y Source hypothetical TermSpec none MOD:00692 MOD:00919 PSI-MOD MOD:01788 histidine immonium ion A protein modification that effectively converts an N-terminal L-histidine residue to histidine immonium ion. 17074506 PubMed 18688235 PubMed This fragment corresponds to the first ion in an a+ series. PSI-MOD-slim 2-(1H-imidazolyl)ethaniminium PSI-MOD-alternate DiffAvg -27.00 DiffFormula C -1 H 1 N 0 O -1 DiffMono -26.987638 FormalCharge 1+ Formula C 5 H 8 N 3 O 0 MassAvg 110.14 MassMono 110.071274 Origin H Source artifact TermSpec none MOD:00909 MOD:01527 PSI-MOD MOD:01789 phenylalanine immonium ion A protein modification that effectively converts an N-terminal L-phenylalanine residue to phenylalanine immonium ion. 17074506 PubMed 18688235 PubMed This fragment corresponds to the first ion in an a+ series. PSI-MOD-slim 2-phenylethaniminium PSI-MOD-alternate DiffAvg -27.00 DiffFormula C -1 H 1 N 0 O -1 DiffMono -26.987638 FormalCharge 1+ Formula C 8 H 10 N 1 O 0 MassAvg 120.17 MassMono 120.080776 Origin F Source artifact TermSpec none MOD:00914 MOD:01527 PSI-MOD MOD:01790 tyrosine immonium ion A protein modification that effectively converts an an N-terminal L-tyrosine residue to tyrosine immonium ion. 17074506 PubMed 18688235 PubMed This fragment corresponds to the first ion in an a+ series. PSI-MOD-slim 2-(4-hydroxyphenyl)ethaniminium PSI-MOD-alternate DiffAvg -27.00 DiffFormula C -1 H 1 N 0 O -1 DiffMono -26.987638 FormalCharge 1+ Formula C 8 H 10 N 1 O 1 MassAvg 136.17 MassMono 136.075690 Origin Y Source artifact TermSpec none MOD:00919 MOD:01527 PSI-MOD MOD:01791 phosphohistidine immonium ion A protein modification that effectively converts an N-terminal phosphohistidine residue to phosphohistidine immonium ion. 17690871 PubMed 18688235 PubMed 20847263 PubMed This fragment corresponds to the first ion in an a+ series. PSI-MOD-slim 2-(1H-imidazolyl)ethaniminium PSI-MOD-alternate DiffAvg -27.00 DiffFormula C -1 H 1 N 0 O -1 DiffMono -26.987638 FormalCharge 1+ Formula C 5 H 9 N 3 O 3 P 1 MassAvg 190.12 MassMono 190.037604 Origin MOD:00890 Source artifact TermSpec none MOD:00909 MOD:01527 derives_from MOD:008900 PSI-MOD MOD:01792 phosphotyrosine immonium ion A protein modification that effectively converts an N-terminal O4'-phospho-L-tyrosine residue to tyrosine immonium ion. 17690871 PubMed 18688235 PubMed This fragment corresponds to the first ion in an a+ series. PSI-MOD-slim 2-(4-phosphonoxyphenyl)ethaniminium PSI-MOD-alternate DiffAvg -27.00 DiffFormula C -1 H 1 N 0 O -1 DiffMono -26.987638 FormalCharge 1+ Formula C 8 H 11 N 1 O 4 P 1 MassAvg 216.15 MassMono 216.042021 Origin MOD:00048 Source artifact TermSpec none MOD:00919 MOD:01527 derives_from MOD:000480 PSI-MOD MOD:01793 S-carboxamidomethyl-L-cysteine sulfoxide A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfoxide. 11212008 PubMed 17689096 PubMed 18306178 PubMed 18688235 PubMed CamCO PSI-MOD-alternate S-carbamoylmethyl-L-cysteine sulfoxide PSI-MOD-alternate DiffAvg 73.05 DiffFormula C 2 H 3 N 1 O 2 DiffMono 73.016378 Formula C 5 H 8 N 2 O 3 S 1 MassAvg 176.19 MassMono 176.025563 Origin C Source artifact TermSpec none MOD:00397 MOD:00708 MOD:01854 derives_from MOD:010600 PSI-MOD MOD:01794 1x(13)C,3x(2)H labeled monomethylated residue A protein modification that effectively replaces the methyl group of a residue containing common isotopes with a 1x(13)C,3x(2)H labeled monomethylated residue. 18688235 PubMed Methyl:2H(3)13C(1) PSI-MS-label DiffAvg 18.04 DiffFormula (13)C 1 (1)H -1 (2)H 3 DiffMono 18.037835 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00839 MOD:00842 PSI-MOD MOD:01795 1x(13)C,3x(2)H C(6)-labeled L-methionine A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine. 15782174 PubMed 18688235 PubMed Methyl:2H(3)13C(1) PSI-MS-label DiffAvg 4.02 DiffFormula (12)C -1 (13)C 1 (1)H -3 (2)H 3 DiffMono 4.022185 Formula (12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 1 S 1 MassAvg 135.06 MassMono 135.062670 Origin M Source artifact TermSpec none MOD:00839 MOD:00913 MOD:01794 PSI-MOD MOD:01796 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide. 15782174 PubMed 18688235 PubMed DiffAvg 20.02 DiffFormula (12)C -1 (13)C 1 (1)H -3 (2)H 3 O 1 DiffMono 20.017100 Formula (12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 2 S 1 MassAvg 151.06 MassMono 151.057585 Origin M Source artifact TermSpec none MOD:00839 MOD:00913 MOD:01794 PSI-MOD MOD:01797 1'-phosphohistidine immonium ion A protein modification that effectively converts an N-terminal 1'-phosphohistidine residue to 1'-phosphohistidine immonium ion. 17690871 PubMed 18688235 PubMed 20847263 PubMed This fragment corresponds to the first ion in an a+ series. 2-((1-phosphono-1H-imidazol-4-yl)ethaniminium PSI-MOD-alternate Ntau-phosphorylated L-histidine PSI-MOD-alternate DiffAvg -27.00 DiffFormula C -1 H 1 N 0 O -1 DiffMono -26.987638 FormalCharge 1+ Formula C 5 H 9 N 3 O 3 P 1 MassAvg 190.12 MassMono 190.037604 Origin MOD:00044 Source artifact TermSpec none MOD:01791 derives_from MOD:000440 PSI-MOD MOD:01798 3'-phosphohistidine immonium ion A protein modification that effectively converts an N-terminal 3'-phosphohistidine residue to 3'-phosphohistidine immonium ion. 18688235 PubMed This fragment corresponds to the first ion in an a+ series. 2-(1-phosphono-1H-imidazol-5-yl)ethaniminium PSI-MOD-alternate Npi-phosphorylated L-histidine PSI-MOD-alternate DiffAvg -27.00 DiffFormula C -1 H 1 N 0 O -1 DiffMono -26.987638 FormalCharge 1+ Formula C 5 H 9 N 3 O 3 P 1 MassAvg 190.12 MassMono 190.037604 Origin MOD:00045 Source artifact TermSpec none MOD:01791 derives_from MOD:000450 PSI-MOD MOD:01799 methylated serine A protein modification that effectively converts an L-alanine residue to a methylated serine, such as N-methylserine, N,N-dimethylserine, or N,N,N-trimethylserine. 18688235 PubMed PSI-MOD-slim MeSer PSI-MOD-label Origin S MOD:00427 MOD:00916 PSI-MOD MOD:01800 N-methylated serine A protein modification that effectively replaces an L-serine alpha amino hydrogen with a methyl group. 18688235 PubMed PSI-MOD-slim Origin S Source natural TermSpec N-term MOD:01460 MOD:01799 PSI-MOD MOD:01801 protonated L-serine (L-serinium) residue A protein modification that effectively converts an L-serine residue to an L-serinium (protonated L-serine). 18688235 PubMed PSI-MOD-slim DiffAvg 1.01 DiffFormula C 0 H 1 N 0 O 0 DiffMono 1.007276 FormalCharge 1+ Formula C 3 H 7 N 1 O 2 MassAvg 89.09 MassMono 89.047130 Origin S Source natural TermSpec N-term MOD:00916 MOD:01700 PSI-MOD MOD:01802 N,N,N-trimethyl-L-serine (from L-serinium) A protein modification that effectively converts an L-serinium (protonated L-serine) residue to an N,N,N-trimethyl-L-serine. 18688235 PubMed For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ser process (MOD:00071) accounts for both protonation and trimethylation. PSI-MOD-slim N2Me3Ala PSI-MOD-label DiffAvg 42.08 DiffFormula C 3 H 6 N 0 O 0 DiffMono 42.046402 FormalCharge 1+ Formula C 6 H 13 N 1 O 2 MassAvg 131.17 MassMono 131.094080 Origin MOD:01801 Source natural TermSpec N-term MOD:01687 derives_from MOD:018010 PSI-MOD MOD:01803 O-methylated threonine A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine or L-threonine methyl ester. 18688235 PubMed OMeThr PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin T Source natural TermSpec none MOD:00393 MOD:01418 PSI-MOD MOD:01804 glycosylphosphorylated residue A protein modification that effectively results from forming an adduct with a glycosylphosphate through a phosphodiester bond. 18688235 PubMed MOD:00764 MOD:00861 PSI-MOD MOD:01805 N-(L-isoaspartyl)-glycine (Asp) A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)-glycine and the release of water. 21479 ChEBI 1826288 PubMed 18671394 PubMed AA0126 RESID Cross-link 2. (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid RESID-systematic 2-amino-N4-(carboxymethyl)-butanediamic acid RESID-alternate CROSSLNK Isoaspartyl glycine isopeptide (Asp-Gly) UniProt-feature CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asp) UniProt-feature isoaspartyl glycine RESID-alternate N-(L-isoaspartyl)-glycine RESID-name N-beta-aspartylglycine RESID-alternate N4-(carboxymethyl)-asparagine RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 6 H 7 N 2 O 3 MassAvg 155.13 MassMono 155.045667 Origin D, G Source natural TermSpec N-term MOD:00904 MOD:00954 MOD:01928 PSI-MOD MOD:01806 N,N-dimethyl-L-leucine A protein modification that effectively converts an L-leucine residue to N,N-dimethyl-L-leucine. 19522542 PubMed AA0538 RESID (2S)-2-(dimethylamino)-4-methylpentanoic acid RESID-systematic 2-(dimethylamino)-4-methylvaleric acid RESID-alternate 2-(dimethylazanyl)-4-methylpentanoic acid RESID-alternate MOD_RES N,N-dimethylleucine UniProt-feature N,N-dimethyl-L-leucine RESID-name N,N-dimethylleucine RESID-alternate DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 16 N 1 O 1 MassAvg 142.22 MassMono 142.123189 Origin L Source hypothetical TermSpec N-term MOD:01686 MOD:01808 PSI-MOD MOD:01807 N-formyl-L-glutamic acid A protein modification that effectively converts an L-glutamic acid residue to N-formyl-L-glutamic acid. 18001127 PubMed AA0539 RESID (2S)-2-(formylamino)pentanedioic acid RESID-systematic 2-(formylazanyl)pentanedioic acid RESID-alternate 2-formamidopentanedioic acid RESID-alternate 2-formylaminopentanedioic acid RESID-alternate N-formyl-L-glutamic acid RESID-name DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 6 H 8 N 1 O 4 MassAvg 158.13 MassMono 158.045333 Origin E Source artifact TermSpec N-term MOD:00409 MOD:00906 PSI-MOD MOD:01808 N-methylated leucine A protein modification that effectively replaces an L-leucine alpha amino hydrogen with a methyl group. 18688235 PubMed PSI-MOD-slim MeLeu PSI-MOD-label Origin L MOD:00662 MOD:01460 PSI-MOD MOD:01809 5x(13)C,1x(15)N labeled residue A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C,1x(15)N labeled residue. 12771378 PubMed 268 UniMod 13C(5) 15N(1) Silac label UniMod-description Label:13C(5)15N(1) PSI-MS-label DiffAvg 6.01 DiffFormula (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono 6.013809 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00842 MOD:00843 PSI-MOD MOD:01810 5x(13)C,1x(15)N labeled L-proline A protein modification that effectively converts an L-proline residue to 5x(13)C,1x(15)N labeled L-proline. 12771378 PubMed 268#P UniMod 13C(5) 15N(1) Silac label UniMod-description Label:13C(5)15N(1) PSI-MS-label DiffAvg 6.01 DiffFormula (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono 6.013809 Formula (13)C 5 H 7 (15)N 1 O 1 MassAvg 103.07 MassMono 103.066573 Origin P Source artifact TermSpec none MOD:00915 MOD:01809 PSI-MOD MOD:01811 5x(13)C,1x(15)N labeled L-methionine A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine. 12771378 PubMed 268#M UniMod 13C(5) 15N(1) Silac label UniMod-description Label:13C(5)15N(1) PSI-MS-label DiffAvg 6.01 DiffFormula (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono 6.013809 Formula (13)C 5 H 9 (15)N 1 O 1 S 1 MassAvg 137.05 MassMono 137.054294 Origin M Source artifact TermSpec none MOD:00913 MOD:01809 PSI-MOD MOD:01812 5x(13)C,1x(15)N labeled L-methionine sulfoxide A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine sulfoxide. 12771378 PubMed 268#M UniMod 13C(5) 15N(1) Silac label UniMod-description Label:13C(5)15N(1) PSI-MS-label DiffAvg 6.01 DiffFormula (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono 6.013809 Formula (13)C 5 H 9 (15)N 1 O 2 S 1 MassAvg 153.05 MassMono 153.049209 Origin M Source artifact TermSpec none MOD:00719 MOD:01809 PSI-MOD MOD:01813 morpholine-2-acetylated residue A protein modification that effectively substitutes a morpholine-2-acetyl group for a hydrogen atom. 10446193 PubMed 29 UniMod The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. N-Succinimidyl-2-morpholine acetate UniMod-description N-succinimidylmorpholine-2-acetate derivative PSI-MOD-alternate SMA PSI-MS-label DiffAvg 127.14 DiffFormula C 6 H 9 N 1 O 2 DiffMono 127.063329 Formula none MassAvg none MassMono none Origin X Source artifact MOD:00649 MOD:00848 PSI-MOD MOD:01814 L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid A protein modification that effectively cross-links a cysteine and two serine residues to form L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid. 18406324 PubMed 19678698 PubMed 893891 PubMed AA0540 RESID Cross-link 3. 6-[(1R)-1-amino-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid RESID-systematic 6-[1-azanyl-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid RESID-alternate L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid RESID-name DiffAvg -54.07 DiffFormula C 0 H -8 N -1 O -2 S 0 DiffMono -54.055504 Formula C 9 H 7 N 2 O 3 S 1 MassAvg 223.23 MassMono 223.017738 Origin C, S, S Source natural TermSpec none MOD:01425 PSI-MOD MOD:01815 L-glutamate thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamic acid residue to form L-glutamate thiazole-4-carboxylic acid. 18406324 PubMed 19678698 PubMed 893891 PubMed AA0541 RESID Cross-link 2. 2-[(1S)-1-amino-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid RESID-systematic 2-[-1-azanyl-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid RESID-alternate CROSSLNK Thiazole-4-carboxylic acid (Glu-Cys) UniProt-feature L-glutamate thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 8 H 8 N 2 O 3 S 1 MassAvg 212.22 MassMono 212.025563 Origin C, E Source natural TermSpec none MOD:00906 MOD:01420 MOD:01888 PSI-MOD MOD:01816 2'-hydroxy-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to a 2'-hydroxy-L-tryptophan. 11714714 PubMed AA0542 RESID (2S)-2-amino-3-(2-hydroxy-1H-indol-3-yl)propanoic acid RESID-systematic 2'-hydroxy-L-tryptophan RESID-name 2-azanyl-3-(2-hydroxy-1H-indol-3-yl)propanoic acid RESID-alternate 2-hydroxy-L-tryptophan RESID-alternate 2-hydroxy-tryptophan RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 11 H 10 N 2 O 2 MassAvg 202.21 MassMono 202.074228 Origin W Source artifact TermSpec none MOD:01622 PSI-MOD MOD:01817 oxidation of tryptophan to 2'-oxo-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to a 2'-oxo-L-tryptophan. 9461080 PubMed AA0543 RESID (2S)-2-amino-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid RESID-systematic 2'-oxo-L-tryptophan RESID-name 2-azanyl-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid RESID-alternate 2-oxo-L-tryptophan RESID-alternate 2-oxotryptophan RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 11 H 10 N 2 O 2 MassAvg 202.21 MassMono 202.074228 Origin W Source artifact TermSpec none MOD:00679 MOD:00918 PSI-MOD MOD:01818 1'-(L-tryptophan-3'-yl)-L-tryptophan A protein modification that effectively cross-links two tryptophan residues to form 1'-(L-tryptophan-3'-yl)-L-tryptophan. 20600836 PubMed AA0544 RESID Cross-link 2. (2S,2'S)-3,3'-(3'H-1,3'-biindole-3,3'-diyl)bis(2-aminopropanoic acid) RESID-alternate 1-(L-tryptophan-3-yl)-L-tryptophan RESID-name 2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid RESID-alternate 3-[(2S)-2-amino-2-carboxyethyl]-3-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-1H-indole RESID-systematic 3-[2-azanyl-2-carboxyethyl]-3-(3-[2-azanyl-2-carboxyethyl]-1H-indol-2-yl)-1H-indole RESID-alternate ditryptophan RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 22 H 18 N 4 O 2 MassAvg 370.41 MassMono 370.142976 Origin W, W Source natural TermSpec none MOD:00692 MOD:00918 PSI-MOD MOD:01819 N6-succinyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-succinyl-L-lysine. 16582421 PubMed 21151122 PubMed AA0545 RESID PSI-MOD-slim (2S)-2-amino-6-[(3-carboxypropanoyl)amino]hexanoic acid RESID-systematic 2-azanyl-6-[(3-carboxypropanoyl)azanyl]hexanoic acid RESID-alternate 4-[[(5S)-5-amino-6-hydroxy-6-oxohexyl]amino]-4-oxobutanoate RESID-alternate MOD_RES N6-succinyllysine UniProt-feature N(epsilon)-(succinyl)lysine RESID-alternate N6-succinyl-L-lysine RESID-name succinyllysine RESID-alternate DiffAvg 100.07 DiffFormula C 4 H 4 N 0 O 3 DiffMono 100.016044 Formula C 10 H 16 N 2 O 4 MassAvg 228.25 MassMono 228.111007 Origin K Source natural TermSpec none MOD:01029 MOD:01875 PSI-MOD MOD:01820 isotope tagged sufhydryl reagent modified cysteine A protein modification that effectively replaces a cysteine sulhydryl hydrogen with an isotope tagged sulfhydryl reagent group. 18688235 PubMed PSI-MOD-slim Origin C Source artifact TermSpec none MOD:00905 MOD:01426 PSI-MOD MOD:01821 cysTMT6plex reporter+balance reagent cysteine disulfide A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex reporter+balance group. 985 UniMod The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim cysteine-reactive Sixplex Tandem Mass Tag(TM) UniMod-description cysTMT6plex UniMod-interim S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin C Source artifact TermSpec none MOD:01428 MOD:01429 MOD:01820 PSI-MOD MOD:01822 cysTMT6plex-zero reporter+balance reagent cysteine disulfide A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-zero reporter+balance group. 984 UniMod The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim cysTMT UniMod-interim Native cysteine-reactive Tandem Mass Tag(TM) UniMod-description S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD-alternate DiffAvg 299.17 DiffFormula (12)C 14 H 25 (14)N 3 O 2 S 1 DiffMono 299.166748 Formula (12)C 17 H 32 (14)N 4 O 4 S 2 MassAvg 420.19 MassMono 420.186498 Origin C Source artifact TermSpec none MOD:01821 PSI-MOD MOD:01823 cysTMT6plex-126 reporter+balance reagent cysteine disulfide A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-126 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim cysteine-reactive Sixplex Tandem Mass Tag(TM) UniMod-description cysTMT6plex UniMod-interim S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD-alternate DiffAvg 304.18 DiffFormula (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono 304.177202 Formula (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg 425.20 MassMono 425.196952 Origin C Source artifact TermSpec none MOD:01821 PSI-MOD MOD:01824 cysTMT6plex-127 reporter+balance reagent cysteine disulfide A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-127 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim cysteine-reactive Sixplex Tandem Mass Tag(TM) UniMod-description cysTMT6plex UniMod-interim S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD-alternate DiffAvg 304.18 DiffFormula (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono 304.177202 Formula (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg 425.20 MassMono 425.196952 Origin C Source artifact TermSpec none MOD:01821 PSI-MOD MOD:01825 cysTMT6plex-128 reporter+balance reagent cysteine disulfide A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-128 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim cysteine-reactive Sixplex Tandem Mass Tag(TM) UniMod-description cysTMT6plex UniMod-interim S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD-alternate DiffAvg 304.18 DiffFormula (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono 304.177202 Formula (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg 425.20 MassMono 425.196952 Origin C Source artifact TermSpec none MOD:01821 PSI-MOD MOD:01826 cysTMT6plex-129 reporter+balance reagent cysteine disulfide A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-129 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim cysteine-reactive Sixplex Tandem Mass Tag(TM) UniMod-description cysTMT6plex UniMod-interim S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD-alternate DiffAvg 304.18 DiffFormula (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono 304.177202 Formula (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg 425.20 MassMono 425.196952 Origin C Source artifact TermSpec none MOD:01821 PSI-MOD MOD:01827 cysTMT6plex-130 reporter+balance reagent cysteine disulfide A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-130 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim cysteine-reactive Sixplex Tandem Mass Tag(TM) UniMod-description cysTMT6plex UniMod-interim S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD-alternate DiffAvg 304.18 DiffFormula (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono 304.177202 Formula (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg 425.20 MassMono 425.196952 Origin C Source artifact TermSpec none MOD:01821 PSI-MOD MOD:01828 cysTMT6plex-131 reporter+balance reagent cysteine disulfide A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-131 reporter+balance group. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim cysteine-reactive Sixplex Tandem Mass Tag(TM) UniMod-description cysTMT6plex UniMod-interim S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD-alternate DiffAvg 304.18 DiffFormula (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono 304.177202 Formula (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg 425.20 MassMono 425.196952 Origin C Source artifact TermSpec none MOD:01821 PSI-MOD MOD:01829 S-carboxymethyl-L-cysteine sulfoxide A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfoxide. 17689096 PubMed 18688235 PubMed CmCO PSI-MOD-alternate DiffAvg 58.04 DiffFormula C 2 H 2 N 0 O 2 S 0 DiffMono 58.005479 Formula C 5 H 7 N 1 O 3 S 1 MassAvg 161.18 MassMono 161.014664 Origin C Source artifact TermSpec none MOD:00399 MOD:00708 MOD:01854 derives_from MOD:010610 PSI-MOD MOD:01830 S-carboxymethyl-L-cysteine sulfone A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfone. 18688235 PubMed CmCO2 PSI-MOD-label DiffAvg 74.03 DiffFormula C 2 H 2 N 0 O 3 S 0 DiffMono 74.000394 Formula C 5 H 7 N 1 O 4 S 1 MassAvg 177.17 MassMono 177.009579 Origin C Source artifact TermSpec none MOD:00399 MOD:00708 MOD:01855 derives_from MOD:010610 PSI-MOD MOD:01831 S-carboxamidomethyl-L-cysteine sulfone A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfone. 18688235 PubMed CamCO2 PSI-MOD-label S-carbamoylmethyl-L-cysteine sulfone PSI-MOD-alternate DiffAvg 89.05 DiffFormula C 2 H 3 N 1 O 3 DiffMono 89.011293 Formula C 5 H 8 N 2 O 4 S 1 MassAvg 192.19 MassMono 192.020478 Origin C Source artifact TermSpec none MOD:00397 MOD:00708 MOD:01855 derives_from MOD:010600 PSI-MOD MOD:01832 5x(13)C-labeled residue A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C-labeled residue. 12771378 PubMed 772 UniMod 13C(5) Silac label UniMod-description Label:13C(5) PSI-MS-label DiffAvg 5.02 DiffFormula (12)C -5 (13)C 5 DiffMono 5.016774 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00842 PSI-MOD MOD:01833 5x(13)C-labeled L-methionine A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine. 18688235 PubMed DiffAvg 5.02 DiffFormula (12)C -5 (13)C 5 H 0 N 0 O 0 S 0 DiffMono 5.016774 Formula (13)C 5 H 9 N 1 O 1 S 1 MassAvg 136.06 MassMono 136.057259 Origin M Source artifact TermSpec none MOD:00913 MOD:01832 PSI-MOD MOD:01834 5x(13)C-labeled L-methionine sulfoxide A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfoxide. 18688235 PubMed DiffAvg 21.01 DiffFormula (12)C -5 (13)C 5 H 0 N 0 O 1 S 0 DiffMono 21.011689 Formula (13)C 5 H 9 N 1 O 2 S 1 MassAvg 152.05 MassMono 152.052174 Origin M Source artifact TermSpec none MOD:00719 MOD:01832 PSI-MOD MOD:01835 5x(13)C-labeled L-methionine sulfone A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfone. 18688235 PubMed DiffAvg 37.01 DiffFormula (12)C -5 (13)C 5 H 0 N 0 O 2 S 0 DiffMono 37.006603 Formula (13)C 5 H 9 N 1 O 3 S 1 MassAvg 168.05 MassMono 168.047088 Origin M Source artifact TermSpec none MOD:00256 MOD:01832 PSI-MOD MOD:01836 N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine A protein modification that effectively converts an L-lysine residue to N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine. 18688235 PubMed 20218600 PubMed 21271704 PubMed (2S)-2-amino-6-[([1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]carbonyl)amino]hexanoic acid PSI-MOD-alternate [(alpha-methyl-6-nitro-piperonyloxy)carbonyl]lysine PSI-MOD-alternate DiffAvg 237.17 DiffFormula C 10 H 7 N 1 O 6 DiffMono 237.027337 Formula C 16 H 19 N 3 O 7 MassAvg 365.34 MassMono 365.122300 Origin K Source artifact TermSpec none MOD:00848 MOD:01875 PSI-MOD MOD:01837 L-lanthionine (Cys-Cys) A protein modification that effectively cross-links two L-cysteine residues with a thioether bond to form L-lanthionine. 21347 ChEBI 20805503 PubMed 6007887 PubMed AA0110#CYS2 RESID Cross-link 2. (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) RESID-systematic (R)-S-(2-amino-2-carboxyethyl)-L-cysteine RESID-alternate (R,R)-2,6-diamino-4-thiaheptanedioic acid RESID-alternate (R,R)-3,3'-thiobis-(2-aminopropanoic acid) RESID-alternate (R,R)-bis(2-amino-2-carboxyethyl)sulfide RESID-alternate 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid RESID-alternate 3,3'-thiobis-L-alanine RESID-alternate L-lanthionine RESID-name DiffAvg -34.08 DiffFormula C 0 H -2 N 0 O 0 S -1 DiffMono -33.987721 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030649 Origin C, C Source hypothetical TermSpec none MOD:01839 PSI-MOD MOD:01838 L-lysinoalanine (Lys) A protein modification that effectively converts an L-lysine residue to L-lysinoalanine. 19155267 PubMed 2544544 PubMed AA0123#LYS RESID This entry is for the modification of peptidyl lysine by a free serine. For the crosslink of peptidyl serine and peptidyl lysine see MOD:00132. (2R,9S)-lysinoalanine RESID-alternate (2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid RESID-systematic alaninolysine RESID-alternate L-lysinoalanine RESID-name LAL RESID-alternate lysino-D-alanine RESID-alternate MOD_RES Lysino-D-alanine (Lys) UniProt-feature N-epsilon-(2-amino-2-carboxyethyl)-L-lysine RESID-alternate N6-(2-amino-2-carboxyethyl)-L-lysine RESID-alternate DiffAvg 87.08 DiffFormula C 3 H 5 N 1 O 2 DiffMono 87.032028 Formula C 9 H 17 N 3 O 3 MassAvg 215.25 MassMono 215.126991 Origin K Source natural TermSpec none MOD:01853 PSI-MOD MOD:01839 L-lanthionine A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. 18688235 PubMed Cross-link 2. For the natural form of the lanthionine cross-link see MOD:00120 meso-lanthionine [JSG]. DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030649 Origin C, X Source artifact TermSpec none MOD:00859 MOD:01841 PSI-MOD MOD:01840 L-allo-isoleucine A protein modification that effectively converts an L-isoleucine residue to L-allo-isoleucine. 43433 ChEBI 20805503 PubMed AA0546 RESID (2S,3R)-2-amino-3-methylpentanoic acid RESID-systematic 2-azanyl-3-methylpentanoic acid RESID-alternate 3-methyl-norvaline RESID-alternate allo-L-isoleucine RESID-alternate alpha-amino-beta-methylvaleric acid RESID-alternate L-allo-isoleucine RESID-name L-threo-isoleucine RESID-alternate MOD_RES L-allo-isoleucine UniProt-feature DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 6 H 11 N 1 O 1 MassAvg 113.16 MassMono 113.084064 Origin I Source natural TermSpec none MOD:00664 MOD:00910 PSI-MOD MOD:01841 lanthionine A protein modification that effectively cross-links either two or an L-cysteine residue and an L-serine residue by a thioether bond to form a lanthionine, either D- or L- or meso-lanthionine. 18688235 PubMed Cross-link 2. [JSG]. 2,6-diamino-4-thiaheptanedioic acid PSI-MOD-alternate 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid PSI-MOD-alternate 3,3'-thiobis-(2-aminopropanoic acid) PSI-MOD-alternate 3,3'-thiobis-L-alanine PSI-MOD-alternate bis(2-amino-2-carboxyethyl)sulfanediyl PSI-MOD-alternate bis(2-amino-2-carboxyethyl)sulfide PSI-MOD-alternate S-(2-amino-2-carboxyethyl)-L-cysteine PSI-MOD-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030649 Origin C, X Source artifact TermSpec none MOD:01993 PSI-MOD MOD:01842 S-(2-aminovinyl)-L-cysteine A protein modification that effectively converts two L-cysteine residues to S-(2-aminovinyl)-L-cysteine. 20805503 PubMed AA0548 RESID Cross-link 2. (2R)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid RESID-systematic (R,Z)-S-(2-aminovinyl)cysteine RESID-alternate S-(2-aminovinyl)-L-cysteine RESID-name DiffAvg -80.10 DiffFormula C -1 H -4 N 0 O -2 S -1 DiffMono -79.993200 Formula C 5 H 7 N 2 O 1 S 1 MassAvg 143.18 MassMono 143.027909 Origin C, C Source natural TermSpec C-term MOD:01851 PSI-MOD MOD:01843 5'-chloro-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to 5'-chloro-L-tryptophan. 18215770 PubMed AA0549 RESID (2S)-2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid RESID-systematic 5'-chloro-L-tryptophan RESID-name MOD_RES 5'-chlorotryptophan UniProt-feature DiffAvg 34.44 DiffFormula C 0 Cl 1 H -1 N 0 O 0 DiffMono 33.961028 Formula C 11 Cl 1 H 9 N 2 O 1 MassAvg 220.66 MassMono 220.040341 Origin W Source natural TermSpec none MOD:01913 PSI-MOD MOD:01844 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid A protein modification that effectively converts an L-cysteine residue and an L-leucine residue to 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid. 15361623 PubMed 18729522 PubMed 20961038 PubMed 21254756 PubMed AA0550 RESID Cross-link 2. (4Z)-4-[hydroxy(sulfanyl)methylidene]-2-(3-methylbutanoyl)-1,3-oxazol-5(4H)-one [tautomer] RESID-alternate 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid RESID-name 5-hydroxy-2-(3-methylbutanoyl)-1,3-oxazole-4-carbothioic O-acid RESID-systematic MOD_RES 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid (Leu-Cys) UniProt-feature DiffAvg -5.06 DiffFormula C 0 H -7 N -1 O 1 S 0 DiffMono -5.062935 Formula C 9 H 10 N 1 O 3 S 1 MassAvg 212.24 MassMono 212.038139 Origin C, L Source natural TermSpec N-term MOD:00905 MOD:00911 MOD:01856 PSI-MOD MOD:01845 L-proline 5-hydroxyoxazole-4-carbothionic acid A protein modification that effectively converts an L-cysteine residue and an L-proline residue to L-proline 5-hydroxyoxazole-4-carbothionic acid. 15361623 PubMed 18729522 PubMed 20961038 PubMed 21254756 PubMed AA0551 RESID Cross-link 2. (4Z)-4-[hydroxy(sulfanyl)methylidene]-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazol-5(4H)-one [tautomer] RESID-alternate 5-hydroxy-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole-4-carbothioic O-acid RESID-systematic CROSSLNK Proline 5-hydroxy-oxazole-4-carbothionic acid (Pro-Cys) UniProt-feature L-proline 5-hydroxy-oxazole-4-carbothionic acid RESID-name DiffAvg -4.03 DiffFormula C 0 H -4 N 0 O 0 S 0 DiffMono -4.031300 Formula C 8 H 8 N 2 O 2 S 1 MassAvg 196.22 MassMono 196.030649 Origin C, P Source natural TermSpec none MOD:00905 MOD:00915 MOD:01856 PSI-MOD MOD:01846 methanobactin OB3b copper complex A protein modification that effectively converts two L-cysteine residues, and a copper atom to the methanobactin OB3b copper complex. 15361623 PubMed 18729522 PubMed 20961038 PubMed 21254756 PubMed AA0552 RESID Cross-link 2. bis[4-(hydroxy[sulfanyl-kappaS]methylidene)-1,3-oxazol-5(4H)-onato-kappaN]copper RESID-systematic METAL copper [Cu-methanobactin OB3b complex] UniProt-feature methanobactin OB3b copper complex RESID-name DiffAvg 85.46 DiffFormula C 0 Cu 1 H -10 N 0 O 2 S 0 DiffMono 84.841176 Formula C 6 Cu 1 H 0 N 2 O 4 S 2 MassAvg 291.74 MassMono 290.859546 Origin C, C Source natural TermSpec N-term MOD:00742 MOD:00905 PSI-MOD MOD:01847 L-cysteine sulfinyl phosphate A protein modification that effectively converts an L-cysteine residue to L-cysteine sulfinyl phosphate. 16565085 PubMed AA0557 RESID (2R)-2-amino-3-[(phosphonooxy)sulfinyl]propanoic acid RESID-systematic cysteine sulfinic phosphoryl ester RESID-alternate L-cysteine sulfinyl phosphate RESID-name DiffAvg 111.98 DiffFormula C 0 H 1 N 0 O 5 P 1 S 0 DiffMono 111.956160 Formula C 3 H 6 N 1 O 6 P 1 S 1 MassAvg 215.12 MassMono 214.965345 Origin C Source hypothetical TermSpec none MOD:00708 MOD:00861 PSI-MOD MOD:01848 S-(spermidinoglutathion-S-yl)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(spermidinoglutathion-S-yl)-L-cysteine. 16613 ChEBI 20530482 PubMed AA0558 RESID (2R)-2-amino-3-([(2R)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-2-([2-([3-([4-aminobutyl]amino)propyl]carbamoyl)methyl]carbamoyl)ethyl]disulfanyl)propanoic acid RESID-systematic cysteine glutathionylspermidine disulfide RESID-alternate L-gamma-glutamyl-[S-(L-cystein-S-yl)]-L-cysteinyl-N-{3-[(4-aminobutyl)amino]propyl}glycinamide RESID-alternate S-(spermidinoglutathion-S-yl)-L-cysteine RESID-name DiffAvg 432.54 DiffFormula C 17 H 32 N 6 O 5 S 1 DiffMono 432.215489 Formula C 20 H 37 N 7 O 6 S 2 MassAvg 535.68 MassMono 535.224674 Origin C Source natural TermSpec none MOD:00905 MOD:01862 PSI-MOD MOD:01849 S-(2-aminovinyl)-D-cysteine (Cys-Cys) A protein modification that effectively cross-links two L-cysteine residues by a thioether bond to form S-(2-aminovinyl)-D-cysteine. 20805503 PubMed AA0204#CYS2 RESID Cross-link 2. (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid RESID-systematic (S,Z)-S-(2-aminovinyl)cysteine RESID-alternate CROSSLNK S-(2-aminovinyl)-D-cysteine (Cys-Cys) UniProt-feature S-(2-aminovinyl)-D-cysteine RESID-name DiffAvg -80.10 DiffFormula C -1 H -4 N 0 O -2 S -1 DiffMono -79.993200 Formula C 5 H 7 N 2 O 1 S 1 MassAvg 143.18 MassMono 143.027909 Origin C, C Source natural TermSpec C-term MOD:01850 PSI-MOD MOD:01850 S-(2-aminovinyl)-D-cysteine A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. AA0204 RESID Cross-link 2. (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid RESID-systematic (S,Z)-S-(2-aminovinyl)cysteine RESID-alternate S-(2-aminovinyl)-D-cysteine RESID-name DiffAvg none DiffFormula none DiffMono none Formula C 5 H 7 N 2 O 1 S 1 MassAvg 143.18 MassMono 143.027909 Origin C, X Source natural TermSpec C-term MOD:01851 PSI-MOD MOD:01851 S-(2-aminovinyl)-cysteine A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-cysteine. 18688235 PubMed Cross-link 2. 2-amino-3-([2-aminoethenyl]sulfanyl)propanoic acid PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none Formula C 5 H 7 N 2 O 1 S 1 MassAvg 143.18 MassMono 143.027909 Origin C, X Source natural TermSpec C-term MOD:00687 MOD:00859 PSI-MOD MOD:01852 L-lysinoalanine (Lys-Cys) A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to release hydrogen sulfide and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid. 0 DeltaMass Cross-link 2. This entry is for a crosslink of peptidyl cysteine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34 with no citation or formula. [JSG] Lysinoalanine (from Cysteine) DeltaMass-label DiffAvg -34.08 DiffFormula C 0 H -2 N 0 O 0 S -1 DiffMono -33.987721 Formula C 9 H 15 N 3 O 2 MassAvg 197.24 MassMono 197.116427 Origin C, K Source hypothetical TermSpec none MOD:00692 MOD:00905 MOD:01853 PSI-MOD MOD:01853 L-lysinoalanine A protein modification that effectively converts an L-lysine residue to L-lysinoalanine either by forming a cross-link with peptidyl-cysteine or peptidyl-serine, or by condensation with free serine. 18688235 PubMed Origin K Source natural TermSpec none MOD:00859 MOD:00912 PSI-MOD MOD:01854 sulfur monooxygenated residue A protein modification that effectively adds one oxygen atom to a sulfur atom of a residue without removing hydrogen atoms. 18688235 PubMed PSI-MOD-slim MOD:00680 PSI-MOD MOD:01855 sulfur dioxygenated residue A protein modification that effectively adds two oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms. 18688235 PubMed PSI-MOD-slim MOD:00680 PSI-MOD MOD:01856 oxazole/oxazoline ring crosslinked residues (Cys) A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid. 18688235 PubMed MOD:01419 PSI-MOD MOD:01857 2-(L-cystein-S-yl)-methionine A protein modification that effectively cross-links an L-cysteine residue and an L-methionine residue by a thioether bond to form 2-(L-cystein-S-yl)-methionine. 20805502 PubMed AA0559 RESID Cross-link 2. The chirality around the methionine alpha-carbon has not been determined. (2R)-2-amino-2-([2-amino-2-carboxyethyl]sulfanyl)-4-(methylsulfanyl)butanoic acid RESID-systematic 2-(L-cystein-S-yl)-methionine RESID-name CROSSLNK 2-(S-cysteinyl)-methionine (Cys-Met) UniProt-feature DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 8 H 12 N 2 O 2 S 2 MassAvg 232.32 MassMono 232.034020 Origin C, M Source natural TermSpec none MOD:00905 MOD:00913 MOD:01992 PSI-MOD MOD:01858 S-(N-acetylamino)glucosyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(N-acetylamino)glucosyl-L-cysteine. 61631 ChEBI 21251913 PubMed 21395300 PubMed AA0560 RESID (2R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosylsulfanyl)propanoic acid RESID-systematic CARBOHYD S-linked (GlcNAc) UniProt-feature S-(N-acetylamino)glucosyl-L-cysteine RESID-name S-[(N-acetylamino)glycosyl]cysteine RESID-alternate S-[beta-D-(N-acetylamino)glucopyranosyl]cysteine RESID-alternate DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 S 0 DiffMono 203.079373 Formula C 11 H 18 N 2 O 6 S 1 MassAvg 306.33 MassMono 306.088557 Origin C Source natural TermSpec none MOD:00426 MOD:00448 MOD:00905 PSI-MOD MOD:01859 4-amino-3-isothiazolidinone-L-phenylalanine A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form 4-amino-3-isothiazolidinone-L-phenylalanine. 17502599 PubMed AA0562 RESID Cross-link 2. (2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-phenylpropanoic acid RESID-systematic 2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-phenylpropanoic acid RESID-alternate 4-amino-3-isothiazolidinone-L-phenylalanine RESID-alternate CROSSLNK N,N-(cysteine-1,S-diyl)phenylalanine (Cys-Phe) UniProt-feature cysteinyl phenylalanine sulfenamide RESID-alternate N,N-(L-cysteine-1,S-diyl)-L-phenylalanine RESID-name phenylalanine-cysteine sulfenyl amide cross-link RESID-alternate phenylalanine-cysteine sulphenyl amide cross-link RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 12 H 12 N 2 O 2 S 1 MassAvg 248.30 MassMono 248.061949 Origin C, F Source hypothetical TermSpec none MOD:00905 MOD:00914 MOD:01861 PSI-MOD MOD:01860 L-cysteine bacillithiol disulfide A protein modification that effectively converts an L-cysteine residue to L-cysteine bacillithiol disulfide. 61338 ChEBI 19578333 PubMed AA0563 RESID (2S)-(2-[S-(L-cystein-S-yl)-L-cysteinyl]amino-2-deoxy-alpha-D-glucopyranosyloxy)-butanedioic acid RESID-systematic BSH RESID-alternate L-cysteine bacillithiol disulfide RESID-name MOD_RES S-bacillithiol cysteine disulfide UniProt-feature DiffAvg 396.37 DiffFormula C 13 H 20 N 2 O 10 S 1 DiffMono 396.083866 Formula C 16 H 25 N 3 O 11 S 2 MassAvg 499.51 MassMono 499.093051 Origin C Source natural TermSpec none MOD:00905 MOD:01862 PSI-MOD MOD:01861 isothiazolidinone ring crosslinked residues A protein modification that crosslinks two residues by condensation of a cysteine thiol with the amido nitrogen of the following residue to form an isothiazolidinone ring. 18688235 PubMed The isothiazolidinone ring is usually formed by the reaction of a cysteine sulfenic acid with the amido nitrogen releasing water. MOD:00033 PSI-MOD MOD:01862 disulfide conjugated residue A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a substituted sulfanyl group, forming a disulfide bond that does not cross-link two encoded peptide chains. 18688235 PubMed PSI-MOD-slim S-thiolation PSI-MOD-alternate Origin C TermSpec none MOD:01886 PSI-MOD MOD:01863 mTRAQ reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems mTRAQ reagent reporter+balance groups. 18688235 PubMed The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01426 MOD:01705 PSI-MOD MOD:01864 mTRAQ light reporter+balance reagent acylated residue A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems mTRAQ light reporter+balance group. 888 UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate mTRAQ heavy UniMod-description DiffAvg 140.09 DiffFormula (12)C 7 H 12 (14)N 2 (16)O 1 DiffMono 140.094963 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:01863 MOD:01868 PSI-MOD MOD:01865 mTRAQ light reporter+balance reagent acylated N-terminal A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems mTRAQ light reporter+balance group. 888#N-term UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate mTRAQ light UniMod-description mTRAQ light on nterm OMSSA-label DiffAvg 140.09 DiffFormula (12)C 7 H 12 (14)N 2 (16)O 1 DiffMono 140.094963 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01864 PSI-MOD MOD:01866 mTRAQ light reporter+balance reagent N6-acylated lysine A protein modification that effectively replaces the N6-amino hydrogen atom of a lysine residue with the Applied Biosystems mTRAQ light reporter+balance group. 888#K UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. PSI-MOD-slim (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate mTRAQ light UniMod-description mTRAQ light on K OMSSA-label DiffAvg 140.09 DiffFormula (12)C 7 H 12 (14)N 2 (16)O 1 DiffMono 140.094963 Formula (12)C 13 H 24 N 2 (14)N 2 O 1 (16)O 1 MassAvg 268.19 MassMono 268.189926 Origin K Source artifact TermSpec none MOD:01864 MOD:01875 PSI-MOD MOD:01867 mTRAQ light reporter+balance reagent O4'-acylated tyrosine A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems mTRAQ light reporter+balance group. 888#Y UniMod The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. (4-methylpiperazin-1-yl)acetyl PSI-MOD-alternate Applied Biosystems mTRAQ(TM) reagent UniMod-alternate mTRAQ light UniMod-description mTRAQ light on Y OMSSA-label DiffAvg 140.09 DiffFormula (12)C 7 H 12 (14)N 2 (16)O 1 DiffMono 140.094963 Formula (12)C 16 H 21 (14)N 3 O 2 (16)O 1 MassAvg 303.16 MassMono 303.158292 Origin Y Source artifact TermSpec none MOD:00919 MOD:01864 PSI-MOD MOD:01868 modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da Modifications that have monoisotopic mass differences from their respective origins of 140.094963 Da. 18688235 PubMed PSI-MOD-slim MOD:01515 PSI-MOD MOD:01869 mTRAQ light reporter fragment The protein modification reporter fragment produced by an Applied Biosystems mTRAQ light reagent derivatized residue. 18688235 PubMed PSI-MOD-slim 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD-alternate DiffAvg none DiffFormula none DiffMono none FormalCharge 1+ Formula (12)C 6 H 13 (14)N 2 MassAvg 113.11 MassMono 113.107325 Origin X Source artifact TermSpec none MOD:01870 derives_from MOD:018640 PSI-MOD MOD:01870 mTRAQ reporter fragment A protein modification reporter fragment produced by an Applied Biosystems mTRAQ reagent derivatized residue. 18688235 PubMed PSI-MOD-slim MOD:01520 PSI-MOD MOD:01871 cyclized N-terminal S-carboxamidomethyl-L-cysteine A protein modification that effectively cyclizes an S-carboxamidomethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of ammonia. 336 DeltaMass 12643538 PubMed 26 UniMod PSI-MOD-slim (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid DeltaMass-label 5-oxothiomorpholine-3-carboxylic acid PSI-MOD-alternate Otc DeltaMass-label Pyro-carbamidomethyl UniMod-interim S-carbamoylmethylcysteine cyclization (N-terminus) UniMod-description DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 S 0 DiffMono -17.026549 Formula C 5 H 6 N 1 O 2 S 1 MassAvg 144.17 MassMono 144.011924 Origin MOD:01060 Source artifact TermSpec N-term MOD:00397 MOD:00419 derives_from MOD:010600 PSI-MOD MOD:01872 cyclized N-terminal S-carboxymethyl-L-cysteine A protein modification that effectively cyclizes an S-carboxymethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of water. 12643538 PubMed 26 UniMod Contrary to the impression given in UniMod entry 26, the cyclization of N-terminal S-carboxymethyl-L-cysteine is not reported in PubMed:1263538. The cyclization would be expected to proceed under strongly acidic conditions [JSG]. PSI-MOD-slim (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid DeltaMass-label 5-oxothiomorpholine-3-carboxylic acid PSI-MOD-alternate Otc DeltaMass-label Pyro-carbamidomethyl UniMod-interim S-carbamoylmethylcysteine cyclization (N-terminus) UniMod-description DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 5 H 6 N 1 O 2 S 1 MassAvg 144.17 MassMono 144.011924 Origin MOD:01061 Source artifact TermSpec N-term MOD:00399 MOD:00419 derives_from MOD:010610 PSI-MOD MOD:01873 N-carboxy-L-alanine A protein modification that effectively converts an L-alanine residue to N-carboxy-L-alanine. 18688235 PubMed 4593770 PubMed 4647257 PubMed 8312270 PubMed This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. (S)-2-carboxyamino-propanoic acid PSI-MOD-alternate 2-carbamic-propanoic acid PSI-MOD-alternate N-carboxymethionine PSI-MOD-alternate DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 DiffMono 43.989829 Formula C 4 H 6 N 1 O 3 MassAvg 116.10 MassMono 116.034768 Origin A Source natural TermSpec N-term MOD:00901 MOD:01152 PSI-MOD MOD:01874 N-carboxy-L-valine A protein modification that effectively converts an L-alanine residue to N-carboxy-L-valine. 18688235 PubMed 4593770 PubMed 4647257 PubMed 8312270 PubMed This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. (S)-2-carboxyamino-propanoic acid PSI-MOD-alternate 2-carbamic-propanoic acid PSI-MOD-alternate N-carboxymethionine PSI-MOD-alternate DiffAvg 44.01 DiffFormula C 1 H 0 N 0 O 2 DiffMono 43.989829 Formula C 6 H 10 N 1 O 3 MassAvg 144.15 MassMono 144.066068 Origin V Source natural TermSpec N-term MOD:00920 MOD:01152 PSI-MOD MOD:01875 N6-acylated L-lysine A protein modification that effectively replaces an N6-amino hydrogen atom of L-lysine with an acyl group. 18688235 PubMed PSI-MOD-slim N6AcylLys PSI-MOD-label Origin K Source natural TermSpec none MOD:00670 MOD:00912 PSI-MOD MOD:01876 4x(1)H,4x(12)C-labeled alpha-amino succinylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(12)C labeled succinyl group. 11857757 PubMed 12175151 PubMed 12716131 PubMed 64 UniMod Succinic anhydride labeling reagent, light form (+4amu, 4H2) site N-term UniMod-description Succinyl PSI-MS-label DiffAvg 100.02 DiffFormula (12)C 4 (1)H 4 O 3 DiffMono 100.016044 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:00457 MOD:01426 PSI-MOD MOD:01877 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid A protein modification that effectively converts an L-cysteine residue and an L-arginine residue to 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid. 20961038 PubMed AA0553 RESID Cross-link 2. (4Z)-2-(4-guanidinobutanoyl)-5-oxo-4-(sulfanylmethylidene)-4,5-dihydro-1H-imidazole RESID-alternate 2-(4-guanidinobutanoyl)-5-hydroxy-1H-imidazole-4-carbothioic O-acid RESID-systematic 2-(4-guanidinobutanoyl)-5-hydroxy-4-thioformyl-1H-imidazole [tautomer] RESID-alternate 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid RESID-name CROSSLNK 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid (Arg-Cys) UniProt-feature DiffAvg -6.05 DiffFormula C 0 H -6 N 0 O 0 S 0 DiffMono -6.046950 Formula C 9 H 12 N 5 O 2 S 1 MassAvg 254.29 MassMono 254.071171 Origin C, R Source natural TermSpec N-term MOD:00902 MOD:00905 MOD:01883 PSI-MOD MOD:01878 L-threonine 5-hydroxyoxazole-4-carbonthionic acid A protein modification that effectively converts an L-cysteine residue and an L-threonine residue to L-threonine 5-hydroxyoxazole-4-carbothionic acid. 20961038 PubMed AA0554 RESID Cross-link 2. (4Z)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-(sulfanylmethylidene)-1,3-oxazol-5(4H)-one [tautomer] RESID-alternate 2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-hydroxy-1,3-oxazole-4-carbothioic O-acid RESID-systematic CROSSLNK Threonine 5-hydroxy-oxazole-4-carbonthionic acid (Thr-Cys) UniProt-feature L-threonine 5-hydroxy-oxazole-4-carbonthionic acid RESID-name DiffAvg -4.03 DiffFormula C 0 H -4 N 0 O 0 S 0 DiffMono -4.031300 Formula C 7 H 8 N 2 O 3 S 1 MassAvg 200.21 MassMono 200.025563 Origin C, T Source natural TermSpec none MOD:00905 MOD:00917 MOD:01856 PSI-MOD MOD:01879 methanobactin SB2 copper complex A protein modification that effectively converts two L-cysteine residues, an L-arginine residue, an L-threonine residue and a copper atom to the methanobactin SB2 copper complex. 20961038 PubMed AA0555 RESID Cross-link 2. [5-(hydroxy[sulfanyl-kappaS]methylene)-3,5-dihydro-4H-imidazol-4-onato-kappaN1][4-(hydroxy[sulfanyl-kappaS]methylene)-1,3-oxazol-5(4H)-onato-kappaN]copper RESID-systematic METAL copper [Cu-methanobactin SB2 complex] UniProt-feature methanobactin SB2 copper complex RESID-name DiffAvg 84.48 DiffFormula C 0 Cu 1 H -9 N 1 O 1 S 0 DiffMono 83.857161 Formula C 6 Cu 1 H 1 N 3 O 3 S 2 MassAvg 290.76 MassMono 289.875530 Origin C, C, R, T Source natural TermSpec N-term MOD:00742 MOD:00905 PSI-MOD MOD:01880 L-deoxyhypusine modification from RESID 50038 ChEBI 16452303 PubMed AA0564 RESID (2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid RESID-systematic deoxyhypusine RESID-alternate L-deoxyhypusine RESID-name N6-(4-aminobutyl)lysine RESID-alternate DiffAvg 71.12 DiffFormula C 4 H 9 N 1 O 0 DiffMono 71.073499 Formula C 10 H 21 N 3 O 1 MassAvg 199.30 MassMono 199.168462 Origin K Source natural TermSpec none MOD:00912 MOD:01884 PSI-MOD MOD:01881 3-(L-phenylalan-2'-yl)-L-valine A protein modification that effectively crosslinks an L-phenylalanine residue and an L-valine residue by a free radical process effectively releasing a hydrogen molecule and forming 3-(L-phenylalan-2'-yl)-L-valine. 21596985 PubMed AA0565 RESID Cross-link 2. (2S)-2-amino-4-(2-[(2S)-2-amino-2-carboxyethyl]phenyl)-3-methylbutanoic acid RESID-systematic 3-(L-phenylalan-2'-yl)-L-valine RESID-name symerythrin valine-phenylalanine cross-link RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula C 14 H 16 N 2 O 2 MassAvg 244.29 MassMono 244.121178 Origin F, V Source natural TermSpec none MOD:00692 MOD:00914 MOD:00920 PSI-MOD MOD:01882 5-imidazolinone ring crosslinked residues (Gly) A protein modification that effectively crosslinks the carbonyl of an amino acid residue at position n with the alpha amino of a glycine residue at position n+2 to form a 5-imidazolinone ring. 18688235 PubMed MOD:00691 PSI-MOD MOD:01883 5-imidazolinone ring crosslinked residues (Cys) A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 5-imidazolinone ring. 18688235 PubMed MOD:00691 PSI-MOD MOD:01884 4-aminobutylated residue A protein modification that effectively replaces a hydrogen atom with a 4-aminobutyl group, usually derived from spermidine. 18688235 PubMed PSI-MOD-slim Origin X TermSpec none MOD:00001 PSI-MOD MOD:01885 biotinylated residue A protein modification that effectively replaces a hydrogen atom with a biotinyl group. 18688235 PubMed PSI-MOD-slim 5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl PSI-MOD-alternate Biotinylation PSI-MOD-alternate BtnRes PSI-MOD-label DiffAvg 226.29 DiffFormula C 10 H 14 N 2 O 2 S 1 DiffMono 226.077599 Formula none MassAvg none MassMono none Origin X Source natural TermSpec none MOD:00649 PSI-MOD MOD:01886 thiolated residue A protein modification that effectively replaces a hydrogen atom with an sulfanyl or substituted sulfanyl group. 18688235 PubMed PSI-MOD-slim Origin X TermSpec none MOD:00860 PSI-MOD MOD:01887 Uniblue A derivatized lysine A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A lysine adduct. 18688235 PubMed PSI-MOD-slim 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate PSI-MOD-alternate 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate PSI-MOD-alternate N6UniblueALys PSI-MOD-label Uniblue A PSI-MOD-alternate DiffAvg 484.50 DiffFormula C 22 H 16 N 2 O 7 S 2 DiffMono 484.039893 Formula C 28 H 28 N 4 O 8 S 2 MassAvg 612.67 MassMono 612.134856 Origin K Source artifact TermSpec none MOD:00912 MOD:01659 PSI-MOD MOD:01888 didehydrogenated residue A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) from a residue. 401 UniMod PSI-MOD-slim 2dHRes PSI-MOD-label DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 DiffMono -2.015650 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00683 PSI-MOD MOD:01889 S-(2-succinyl)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(2-succinyl)-L-cysteine, by addition of either fumaric acid or maleic acid. 16624247 PubMed 18448829 PubMed 20677745 PubMed AA0561 RESID 957 UniMod (2R)-2-amino-3-([(1R)-1,2-dicarboxyethyl]sulfanyl)propanoic acid RESID-systematic (2R)-2-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanedioic acid RESID-alternate 2-((2-amino-2-carboxyethyl)thio)butanedioic acid RESID-alternate 2-amino-3-(1,2-dicarboxyethylthio)propanoic acid RESID-alternate S-(1,2-dicarboxyethyl)cysteine RESID-alternate S-(2-succinyl)-L-cysteine RESID-name S-(2-succinyl)cysteine RESID-alternate S-[(2R)-2-succinyl]-L-cysteine RESID-alternate DiffAvg 116.07 DiffFormula C 4 H 4 N 0 O 4 S 0 DiffMono 116.010959 Formula C 7 H 9 N 1 O 5 S 1 MassAvg 219.21 MassMono 219.020143 Origin C Source natural TermSpec none MOD:00001 MOD:00905 PSI-MOD MOD:01890 N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) A protein modification that effectively crosslinks an N-formyl-L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine. 19622680 PubMed AA0566#FMET RESID Cross-link 2. (2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid RESID-systematic N-[(L-histidin-1'-yl)methyl]-L-methionine RESID-name DiffAvg -16.00 DiffFormula C 0 H 0 N 0 O -1 S 0 DiffMono -15.994915 Formula C 12 H 17 N 4 O 2 S 1 MassAvg 281.35 MassMono 281.107222 Origin H, MOD:00030 Source hypothetical TermSpec N-term MOD:00909 MOD:01450 PSI-MOD MOD:01891 N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) A protein modification that effectively crosslinks an L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine. 19622680 PubMed AA0566#MET RESID Cross-link 2. (2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid RESID-systematic N-[(L-histidin-1'-yl)methyl]-L-methionine RESID-name DiffAvg 12.01 DiffFormula C 1 H 0 N 0 O 0 S 0 DiffMono 12.000000 Formula C 12 H 17 N 4 O 2 S 1 MassAvg 281.35 MassMono 281.107222 Origin H, M Source hypothetical TermSpec N-term MOD:00909 MOD:00913 PSI-MOD MOD:01892 N6-crotonyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-crotonyl-L-lysine. 21925322 PubMed AA0567 RESID (2S)-2-amino-6-[(2E)-but-2-enamido]hexanoic acid RESID-alternate (2S)-2-amino-6-[(2E)-but-2-enoylamino]hexanoic acid RESID-systematic (2S)-2-azanyl-6-[(2E)-but-2-enoylazanyl]hexanoic acid RESID-alternate MOD_RES N6-crotonyl-L-lysine UniProt-feature N(epsilon)-crotonyllysine RESID-alternate N6-(E)-crotonyllysine RESID-alternate N6-[(2E)-2-butenoyl]-L-lysine RESID-alternate N6-crotonyl-L-lysine RESID-name N6-crotonyllysine RESID-alternate N6-trans-crotonyllysine RESID-alternate DiffAvg 68.07 DiffFormula C 4 H 4 N 0 O 1 DiffMono 68.026215 Formula C 10 H 16 N 2 O 2 MassAvg 196.25 MassMono 196.121178 Origin K Source hypothetical TermSpec none MOD:01875 PSI-MOD MOD:01893 N6-malonyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-malonyl-L-lysine. 21908771 PubMed 8349414 PubMed AA0568 RESID (2S)-2-amino-6-[(carboxyacetyl)amino]hexanoic acid RESID-systematic 2-azanyl-6-[(carboxyacetyl)azanyl]hexanoic acid RESID-alternate malonyllysine RESID-alternate MOD_RES N6-malonyllysine UniProt-feature N(epsilon)-(malonyl)lysine RESID-alternate N6-(carboxyacetyl)lysine RESID-alternate N6-malonyl-L-lysine RESID-name N6-malonyllysine RESID-alternate DiffAvg 86.05 DiffFormula C 3 H 2 N 0 O 3 DiffMono 86.000394 Formula C 9 H 14 N 2 O 4 MassAvg 214.22 MassMono 214.095357 Origin K Source hypothetical TermSpec none MOD:01875 PSI-MOD MOD:01894 propanoylated residue A protein modification that effectively replaces a hydrogen atom with an propanoyl group. 11857757 PubMed 11999733 PubMed 12175151 PubMed 58 UniMod Propionate labeling reagent light form (N-term & K) UniMod-description Propionyl PSI-MS-label DiffAvg 56.06 DiffFormula C 3 H 4 O 1 DiffMono 56.026215 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00649 PSI-MOD MOD:01895 alpha-amino 3x(12)C-labeled propanoylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(12)C-labeled propanoyl group. 11857757 PubMed 11999733 PubMed 12175151 PubMed 58#N-term UniMod Propionate labeling reagent light form (N-term & K) UniMod-description Propionyl PSI-MS-label DiffAvg 56.03 DiffFormula (12)C 3 H 4 O 1 DiffMono 56.026215 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00451 PSI-MOD MOD:01896 trifluoroacetic acid adduct A protein modification produced by trifluoroacetic acid forming an adduct, either a salt or a hydrogen bonded carboxylic acid dimer, with an amino acid residue. 18688235 PubMed Trifluoroacetic acid has been observed to form adducts in both negative and positive mode analysis (Mark Collins, private communication) [JSG]. TFA DeltaMass-label DiffAvg 114.02 DiffFormula C 2 F 3 H 1 O 2 DiffMono 113.992864 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00498 MOD:00848 PSI-MOD MOD:01897 5-hydroxy-3-methyl-L-proline (Ile) A protein modification that effectively converts an L-isoleucine residue to 5-hydroxy-3-methyl-L-proline. 21788474 PubMed 7592021 PubMed 8557573 PubMed AA0473 RESID (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid RESID-systematic 5-hydroxy-3-methyl-L-proline RESID-name 5-hydroxy-3-methylproline RESID-alternate 5Hy3MePro(Ile) PSI-MOD-label beta-methyl-delta-hydroxyproline RESID-alternate MOD_RES 5-hydroxy-3-methylproline (Ile) UniProt-feature DiffAvg 13.98 DiffFormula C 0 H -2 N 0 O 1 DiffMono 13.979265 Formula C 6 H 9 N 1 O 2 MassAvg 127.14 MassMono 127.063329 Origin I Source natural TermSpec none MOD:00601 MOD:00679 MOD:00910 MOD:01888 MOD:01905 PSI-MOD MOD:01898 N2,N2-dimethyl-L-arginine modification from RESID 21568297 PubMed 21950656 PubMed AA0569 RESID (2S)-5-[(diaminomethylidene)amino]-2-(dimethylamino)pentanoic acid RESID-systematic (2S)-5-carbamimidamido-2-(dimethylamino)pentanoic acid [tautomer] RESID-alternate MOD_RES N2,N2-dimethylarginine UniProt-feature N(alpha),N(alpha)-dimethylarginine RESID-alternate N2,N2-dimethyl-L-arginine RESID-name N2,N2-dimethylarginine RESID-alternate DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 8 H 17 N 4 O 1 MassAvg 185.25 MassMono 185.140236 Origin R Source natural TermSpec N-term MOD:00783 PSI-MOD MOD:01899 L-arginine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-arginine residue and an L-cysteine residue to form arginine thiazole-4-carboxylic acid. 21568297 PubMed 21950656 PubMed AA0570 RESID Cross-link 2. 2-[(1S)-1-amino-4-([diaminomethylidene]amino)butyl]-1,3-thiazole-4-carboxylic acid RESID-systematic CROSSLNK Thiazole-4-carboxylic acid (Arg-Cys) UniProt-feature L-arginine thiazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 9 H 13 N 5 O 1 S 1 MassAvg 239.30 MassMono 239.084081 Origin C, R Source natural TermSpec none MOD:00902 MOD:01420 MOD:01888 PSI-MOD MOD:01900 L-cysteine 5-methyloxazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-cysteine 5-methyloxazole-4-carboxylic acid. 21568297 PubMed 21950656 PubMed AA0571 RESID Cross-link 2. 2-[(1R)-1-amino-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid RESID-systematic 2-[(1R)-1-azanyl-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid RESID-alternate CROSSLNK 5-methyloxazole-4-carboxylic acid (Cys-Thr) UniProt-feature L-cysteine 5-methyloxazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 S 0 DiffMono -20.026215 Formula C 7 H 8 N 2 O 2 S 1 MassAvg 184.21 MassMono 184.030649 Origin C, T Source natural TermSpec none MOD:00905 MOD:01422 MOD:01888 PSI-MOD MOD:01901 L-threonine 5-methyloxazole-4-carboxylic acid A protein modification that effectively crosslinks two L-threonine residues to form L-threonine 5-methyloxazole-4-carboxylic acid. 21568297 PubMed 21950656 PubMed AA0572 RESID Cross-link 2. 2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid RESID-systematic 2-[(1S,2R)-1-azanyl-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid RESID-alternate CROSSLNK 5-methyloxazole-4-carboxylic acid (Thr-Thr) UniProt-feature L-threonine 5-methyloxazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 DiffMono -20.026215 Formula C 8 H 10 N 2 O 3 MassAvg 182.18 MassMono 182.069142 Origin T, T Source natural TermSpec none MOD:01422 MOD:01888 PSI-MOD MOD:01902 L-isoleucine oxazole-4-carboxylic acid A protein modification that effectively crosslinks an L-isoleucine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid. 21568297 PubMed 21950656 PubMed AA0573 RESID Cross-link 2. 2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-oxazole-4-carboxylic acid RESID-systematic 2-[(1S,2S)-1-azanyl-2-methylbutyl]-1,3-oxazole-4-carboxylic acid RESID-alternate CROSSLNK Oxazole-4-carboxylic acid (Ile-Ser) UniProt-feature L-isoleucine oxazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 DiffMono -20.026215 Formula C 9 H 12 N 2 O 2 MassAvg 180.21 MassMono 180.089878 Origin I, S Source natural TermSpec none MOD:00910 MOD:01421 MOD:01888 PSI-MOD MOD:01903 L-serine oxazole-4-carboxylic acid A protein modification that effectively crosslinks two L-serine residues to form serine oxazole-4-carboxylic acid. 21568297 PubMed 21950656 PubMed AA0574 RESID Cross-link 2. 2-[(1S)-1-amino-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid RESID-systematic 2-[(1S)-1-azanyl-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid RESID-alternate CROSSLNK Oxazole-4-carboxylic acid (Ser-Ser) UniProt-feature L-serine oxazole-4-carboxylic acid RESID-name DiffAvg -20.03 DiffFormula C 0 H -4 N 0 O -1 DiffMono -20.026215 Formula C 6 H 6 N 2 O 3 MassAvg 154.13 MassMono 154.037842 Origin S, S Source natural TermSpec none MOD:01421 MOD:01888 PSI-MOD MOD:01904 L-serine 5-methyloxazoline-4-carboxylic acid A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazoline-4-carboxylic acid. 21568297 PubMed 21950656 PubMed AA0575 RESID Cross-link 2. 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazoline-4-carboxylic acid RESID-alternate 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid RESID-systematic 2-[(1S)-1-azanyl-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid RESID-alternate CROSSLNK 5-methyloxazoline-4-carboxylic acid (Ser-Thr) UniProt-feature L-serine 5-methyloxazoline-4-carboxylic acid RESID-name DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 7 H 10 N 2 O 3 MassAvg 170.17 MassMono 170.069142 Origin S, T Source natural TermSpec none MOD:00916 MOD:01422 PSI-MOD MOD:01905 5-hydroxy-3-methyl-L-proline A protein modification that effectively converts a source amino acid residue to 5-hydroxy-3-methyl-L-proline. 7592021 PubMed 8557573 PubMed AA0473 RESID (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid RESID-systematic 5-hydroxy-3-methyl-L-proline RESID-name 5-hydroxy-3-methylproline RESID-alternate 5Hy3MePro PSI-MOD-label beta-methyl-delta-hydroxyproline RESID-alternate MOD_RES 5-hydroxy-3-methylproline (Ile) UniProt-feature DiffAvg none DiffFormula none DiffMono none Formula C 6 H 9 N 1 O 2 MassAvg 127.14 MassMono 127.063329 Origin X Source natural TermSpec none MOD:00859 has_functional_parent MOD:010240 PSI-MOD MOD:01906 dehydromethionine A protein modification that effectively converts an L-methionine residue to dehydromethionine. 18688235 PubMed 19775156 PubMed (3S)-3-carboxy-1-methylisothiazolidin-1-ium PSI-MOD-alternate L-dehydromethionine PSI-MOD-alternate DiffAvg -1.01 DiffFormula C 0 H -1 N 0 O 0 S 0 DiffMono -1.008374 FormalCharge 1+ Formula C 5 H 9 N 1 O 1 S 1 MassAvg 131.19 MassMono 131.039936 Origin M Source artifact TermSpec N-term MOD:00601 MOD:00913 PSI-MOD MOD:01907 dehydromethionine (from L-methioninium) A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to dehydromethionine. 18688235 PubMed 19775156 PubMed This process accounts only for cyclizaation and not protonation. The alternative process (MOD:01906) accounts for both protonation and cyclization. (3S)-3-carboxy-1-methylisothiazolidin-1-ium PSI-MOD-alternate L-dehydromethionine PSI-MOD-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.016199 FormalCharge 1+ Formula C 5 H 9 N 1 O 1 S 1 MassAvg 131.19 MassMono 131.039936 Origin MOD:001464 Source artifact TermSpec N-term MOD:00601 MOD:00913 derives_from MOD:014640 PSI-MOD MOD:01908 4-sulfophenyl isothiocyanate alpha-amino derivatized residue A protein modification that effectively converts a residue to the 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue. 14689565 PubMed 14745769 PubMed 15549660 PubMed 16526082 PubMed 261#N-term UniMod 4-sulfophenyl isothiocyanate UniMod-description alpha-amino-[(4-sulfophenyl)carbamothioyl] residue PSI-MOD-alternate SPITC PSI-MS-label DiffAvg 215.24 DiffFormula C 7 H 5 N 1 O 3 S 2 DiffMono 214.971085 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00584 PSI-MOD MOD:01909 6x(13)C labeled 4-sulfophenyl isothiocyanate alpha-amino derivatized residue A protein modification that effectively converts a residue to the 6x(13)C labeled 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue. 11467524 PubMed 16526082 PubMed 464#N-term UniMod 4-sulfophenyl isothiocyanate (Heavy C13) UniMod-description SPITC:13C(6) PSI-MS-label DiffAvg 220.99 DiffFormula (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 DiffMono 220.991214 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00880 PSI-MOD MOD:01910 monofluorinated residue A protein modification that effectively substitutes one hydrogen atom of a residue with one fluorine atom. 127 UniMod F1Res PSI-MOD-label DiffAvg 17.99 DiffFormula C 0 F 1 H -1 N 0 O 0 DiffMono 17.990578 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00498 PSI-MOD MOD:01911 monochlorinated residue A protein modification that effectively substitutes one hydrogen atom of a residue with one chlorine atom. 936 UniMod Cl1Res PSI-MOD-label DiffAvg 34.44 DiffFormula C 0 Cl 1 H -1 N 0 O 0 DiffMono 33.961028 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00753 PSI-MOD MOD:01912 monobrominated residue A protein modification that effectively substitutes one hydrogen atom of a residue with one bromine atom. 340 UniMod Br1Res PSI-MOD-label DiffAvg 78.90 DiffFormula Br 1 C 0 H -1 N 0 O 0 DiffMono 77.910512 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec none MOD:00754 PSI-MOD MOD:01913 monochlorinated L-tryptophan A protein modification that effectively substitutes one hydrogen atom of an L-tryptophan residue with one chlorine atom. 18688235 PubMed Cl1Trp PSI-MOD-label DiffAvg 34.44 DiffFormula C 0 Cl 1 H -1 N 0 O 0 DiffMono 33.961028 Formula C 11 Cl 1 H 9 N 2 O 1 MassAvg 220.66 MassMono 220.040341 Origin W Source artifact TermSpec none MOD:01068 MOD:01911 PSI-MOD MOD:01914 O5-galactosyl-L-hydroxylysine A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine. 17516569 PubMed 907 UniMod Secondary to RESID:AA0028. This intermediate is rarely observed [JSG]. PSI-MOD-slim Galactosyl hydroxylysine UniMod-description OGal5HyLys PSI-MOD-label DiffAvg 178.14 DiffFormula C 6 H 10 N 0 O 6 DiffMono 178.047738 Formula C 16 H 22 N 2 O 7 MassAvg 354.36 MassMono 354.142701 Origin K Source natural TermSpec none MOD:00037 MOD:00396 MOD:00476 PSI-MOD MOD:01915 N-formyl-L-alanine A protein modification that effectively converts an L-alanine residue to N-formyl-L-alanine. 9334739 PubMed AA0576 RESID (2S)-2-(formylamino)propanoic acid RESID-systematic 2-formamidopropanoic acid RESID-alternate 2-formamidopropionic acid RESID-alternate N-formyl-L-alanine RESID-name DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 4 H 6 N 1 O 2 MassAvg 100.10 MassMono 100.039853 Origin A Source hypothetical TermSpec N-term MOD:00409 MOD:00901 PSI-MOD MOD:01916 O4'-(N-acetylamino)galactosyl-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-(N-acetylamino)galactosyl-L-tyrosine. 21712440 PubMed 21983924 PubMed AA0577 RESID (2S)-2-amino-3-(D-2-acetamido-2-deoxygalactopyranosyloxy)phenylpropanoic acid RESID-systematic CARBOHYD O-linked (GalNAc) UniProt-feature mucin type O-glycosyltyrosine RESID-alternate O4'-(N-acetylamino)galactosyl-L-tyrosine RESID-name O4'-(N-acetylgalactosaminyl)tyrosine RESID-alternate O4'-glycosyl-L-tyrosine RESID-alternate DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 17 H 22 N 2 O 7 MassAvg 366.37 MassMono 366.142701 Origin Y Source natural TermSpec none MOD:00563 MOD:01927 PSI-MOD MOD:01917 N6-(L-isoaspartyl)-L-lysine (Asp) A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of water. 21862 ChEBI 11000116 PubMed 15044436 PubMed 18063798 PubMed 6503713 PubMed AA0294#ASP RESID Cross-link 2. (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid RESID-systematic beta-(N6-lysyl)aspartyl acid RESID-alternate CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) UniProt-feature isoaspartyl N6-lysine RESID-alternate N(epsilon)-(beta-aspartyl)lysine RESID-alternate N6-(L-isoaspartyl)-L-lysine RESID-name XLNK-4Asp-N6Lys(Asp) PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 10 H 15 N 3 O 3 MassAvg 225.25 MassMono 225.111341 Origin D, K Source natural TermSpec none MOD:00904 MOD:01929 PSI-MOD MOD:01918 (2S,5S)-5-hydroxylysine A protein modification that effectively converts an L-lysine residue to (2S,5S)-5-hydroxylysine. 19574390 PubMed 22238144 PubMed AA0578 RESID PSI-MOD-slim (2S,5S)-2,6-diamino-5-hydroxyhexanoic acid RESID-systematic (2S,5S)-5-hydroxylysine RESID-name 2,6-bisazanyl-5-hydroxyhexanoic acid RESID-alternate 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid RESID-alternate alpha,epsilon-diamino-delta-hydroxycaproic acid RESID-alternate L-allo-delta-hydroxylysine RESID-alternate L-threo-delta-hydroxylysine RESID-alternate MOD_RES (5S)-5-hydroxylysine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 12 N 2 O 2 MassAvg 144.17 MassMono 144.089878 Origin K Source natural TermSpec none MOD:00037 PSI-MOD MOD:01919 (2S,3S)-3-hydroxyaspartic acid A protein modification that effectively converts an L-aspartic acid residue to (2S,3S)-3-hydroxyaspartic acid. 10696 ChEBI 21177872 PubMed AA0579 RESID PSI-MOD-slim (2S,3S)-2-amino-3-hydroxybutanedioic acid RESID-systematic (2S,3S)-3-hydroxyaspartic acid RESID-name (3S)-3-hydroxy-L-aspartic acid RESID-alternate 2-amino-3-hydroxysuccinic acid RESID-alternate 2-azanyl-3-hydroxybutanedioic acid RESID-alternate 3-hydroxyaspartic acid RESID-alternate L-threo-3-hydroxyaspartic acid RESID-alternate L-threo-beta-hydroxyaspartic acid RESID-alternate MOD_RES (3S)-3-hydroxyaspartate UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 4 H 5 N 1 O 4 MassAvg 131.09 MassMono 131.021858 Origin D Source natural TermSpec none MOD:01926 PSI-MOD MOD:01920 3-hydroxy-L-histidine A protein modification that effectively converts an L-histidine residue to 3-hydroxy-L-histidine. 21251231 PubMed AA0580 RESID (2S)-2-amino-3-hydroxy-3-(1H-imidazol-4-yl)propanoic acid RESID-systematic 3-hydroxy-L-histidine RESID-name MOD_RES 3-hydroxyhistidine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 7 N 3 O 2 MassAvg 153.14 MassMono 153.053826 Origin H Source natural TermSpec none MOD:00677 PSI-MOD MOD:01921 D-aspartic acid (Asp) A protein modification that effectively converts an L-aspartic acid residue to D-aspartic acid. 48094 ChEBI 9384562 PubMed AA0190#ASP RESID (2R)-2-aminobutanedioic acid RESID-systematic 2-azanylbutanedioic acid RESID-alternate aminosuccinic acid RESID-alternate D-aspartic acid RESID-name DiffAvg 0.00 DiffFormula C 0 H 0 N 0 O 0 DiffMono 0.000000 Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin D Source artifactual TermSpec none MOD:00904 MOD:01942 PSI-MOD MOD:01922 3-methoxydehydroalanine A protein modification that effectively converts an L-serine residue to 3-methoxydehydroalanine. 19745839 PubMed AA0582 RESID 2-amino-3-methoxyprop-2-enoic acid RESID-systematic 3-methoxydehydroalanine RESID-name 3-methoxydidehydroalanine RESID-alternate DiffAvg 12.01 DiffFormula C 1 H 0 N 0 O 0 DiffMono 12.000000 Formula C 4 H 5 N 1 O 2 MassAvg 99.09 MassMono 99.032028 Origin S Source natural TermSpec none MOD:00916 has_functional_parent MOD:001890 PSI-MOD MOD:01923 N6-(L-aspartyl)-L-lysine A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-aspartyl)-L-lysine and the release of water. 15044436 PubMed AA0583 RESID Cross-link 2. (2S)-2-amino-6-([(2S)-2-amino-3-carboxypropanoyl]amino)hexanoic acid RESID-systematic alpha-(N6-lysyl)aspartyl acid RESID-alternate aspartyl N6-lysine RESID-alternate N(epsilon)-(alpha-aspartyl)lysine RESID-alternate N6-(L-aspartyl)-L-lysine RESID-name XLNK-4Asp-N6Lys(Asp) PSI-MOD-label DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 10 H 16 N 3 O 4 MassAvg 242.26 MassMono 242.114081 Origin D, K Source natural TermSpec C-term MOD:00688 MOD:00904 MOD:00954 MOD:01875 PSI-MOD MOD:01924 S-octanoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-octanoyl-L-cysteine. 12591875 PubMed 16342964 PubMed AA0584 RESID (2S)-2-amino-3-(octanoylsulfanyl)propanoic acid RESID-systematic 2-amino-3-(octanoylthio)propanoic acid RESID-alternate ACT_SITE Acyl-thioester intermediate UniProt-feature cysteine octanoate thioester RESID-alternate S-octanoyl-L-cysteine RESID-name DiffAvg 126.20 DiffFormula C 8 H 14 N 0 O 1 S 0 DiffMono 126.104465 Formula C 11 H 19 N 1 O 2 S 1 MassAvg 229.34 MassMono 229.113650 Origin C Source natural TermSpec none MOD:00666 MOD:00672 MOD:00905 PSI-MOD MOD:01925 (2S,5R)-5-hydroxylysine A protein modification that effectively converts an L-lysine residue to (2S,5R)-5-hydroxylysine. 18040 ChEBI 13375629 PubMed 15504407 PubMed 16101297 PubMed 2857489 PubMed AA0028 RESID PSI-MOD-slim (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid RESID-systematic (2S,5R)-5-hydroxylysine RESID-name 2,6-bisazanyl-5-hydroxyhexanoic acid RESID-alternate 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid RESID-alternate 5-hydroxylated L-lysine PSI-MOD-alternate 5HyLys PSI-MOD-label alpha,epsilon-diamino-delta-hydroxycaproic acid RESID-alternate L-erythro-delta-hydroxylysine RESID-alternate MOD_RES (2S,5R)-5-hydroxylysine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 12 N 2 O 2 MassAvg 144.17 MassMono 144.089878 Origin K Source natural TermSpec none MOD:00037 PSI-MOD MOD:01926 3-hydroxy-L-aspartic acid A protein modification that effectively converts an L-aspartic acid residue to one of the diastereomeric 3-hydroxy-L-aspartic acid residues. 35#D UniMod PSI-MOD-slim (2S)-2-amino-3-hydroxybutanedioic acid PSI-MOD-alternate (2S)-3-hydroxyaspartic acid PSI-MOD-alternate 3HyAsp PSI-MOD-label erythro-beta-hydroxylated L-aspartic acid PSI-MOD-alternate hydroxylationd OMSSA-label monohydroxylated aspartic acid PSI-MOD-alternate Oxidation PSI-MS-label DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 4 H 5 N 1 O 4 MassAvg 131.09 MassMono 131.021858 Origin D Source natural TermSpec none MOD:00425 MOD:00904 PSI-MOD MOD:01927 O-glycosyl-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-glycosyltyrosine. 18688235 PubMed PSI-MOD-slim OGlycoTyr PSI-MOD-label Origin Y Source natural TermSpec none MOD:00396 MOD:00919 PSI-MOD MOD:01928 N-(L-isoaspartyl)-glycine A protein modification that effectively crosslinks either an L-asparagine residue or an L-aspartic acid residue with a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine. 21479 ChEBI 1826288 PubMed AA0126 RESID Cross-link 2. (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid RESID-systematic 2-amino-N4-(carboxymethyl)-butanediamic acid RESID-alternate isoaspartyl glycine RESID-alternate N-(L-isoaspartyl)-glycine RESID-name N-beta-aspartylglycine RESID-alternate N4-(carboxymethyl)-asparagine RESID-alternate XLNK-4Asp-NGly PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula C 6 H 7 N 2 O 3 MassAvg 155.13 MassMono 155.045667 Origin G Source natural TermSpec N-term MOD:00688 MOD:00908 PSI-MOD MOD:01929 N6-(L-isoaspartyl)-L-lysine A protein modification that effectively crosslinks an either an L-asparagine residue or an L-aspartic acid residue with an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine. 21862 ChEBI 0 DeltaMass 11000116 PubMed 6503713 PubMed AA0294 RESID Cross-link 2. (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid RESID-systematic beta-(N6-lysyl)aspartyl acid RESID-alternate CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) UniProt-feature isoaspartyl N6-lysine RESID-alternate N(epsilon)-(beta-aspartyl)lysine RESID-alternate N-(beta-Aspartyl)-Lysine (Crosslink) DeltaMass-label N6-(L-isoaspartyl)-L-lysine RESID-name XLNK-4Asp-N6Lys PSI-MOD-label DiffAvg none DiffFormula none DiffMono none Formula C 10 H 15 N 3 O 3 MassAvg 225.25 MassMono 225.111341 Origin K Source natural TermSpec none MOD:00688 MOD:01875 PSI-MOD MOD:01930 D-aspartic acid (Asn) A protein modification that effectively converts an L-asparagine residue to D-aspartic acid. 48094 ChEBI 9384562 PubMed AA0190#ASN RESID (2R)-2-aminobutanedioic acid RESID-systematic 2-azanylbutanedioic acid RESID-alternate aminosuccinic acid RESID-alternate D-aspartic acid RESID-name DiffAvg 0.98 DiffFormula C 0 H -1 N -1 O 1 DiffMono 0.984016 Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin N Source artifactual TermSpec none MOD:00903 MOD:01942 PSI-MOD MOD:01931 N6-phospho-L-lysine A protein modification that effectively converts an L-lysine residue to N6-phospho-L-lysine. 20144148 PubMed AA0585 RESID (2S)-2-amino-6-(phosphonoamino)hexanoic acid RESID-systematic (2S)-2-azanyl-6-(phosphonoamino)hexanoic acid RESID-alternate 6-phospholysine RESID-alternate N(6)-phosphonolysine RESID-alternate N(epsilon)-phospholysine RESID-alternate N(epsilon)-phosphonolysine RESID-alternate N(epsilon)-phosphonyllysine RESID-alternate N(epsilon)-phosphoryllysine RESID-alternate N6-phospho-L-lysine RESID-name DiffAvg 79.98 DiffFormula C 0 H 1 N 0 O 3 P 1 DiffMono 79.966331 Formula C 6 H 13 N 2 O 4 P 1 MassAvg 208.15 MassMono 208.061294 Origin K Source hypothetical TermSpec none MOD:00912 MOD:01456 PSI-MOD MOD:01932 L-lysinonorleucine A protein modification that effectively cross-links two lysine residues with a carbon-nitrogen bond to form L-lysinonorleucine.. 5117030 PubMed 5817620 PubMed 5879466 PubMed 6030254 PubMed AA0586 RESID Cross-link 2. (2S)-2-amino-6-([(5S)-5-amino-5-carboxypentyl]amino)hexanoic acid RESID-systematic (2S,2'S)-6,6'-iminobis(2-aminohexanoic acid) RESID-alternate 6-(N6-L-lysino)-L-norleucine RESID-alternate L-lysinonorleucine RESID-name lysinonorleucine RESID-alternate lysinorleucine [misspelling] RESID-alternate lysylnorleucine RESID-alternate N6-[(5S)-5-amino-5-carboxypentyl]-L-lysine RESID-alternate DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 12 H 21 N 3 O 2 MassAvg 239.32 MassMono 239.163377 Origin K, K Source natural TermSpec none MOD:00912 MOD:00946 PSI-MOD MOD:01933 desmosine A protein modification that effectively cross-links four L-lysine residues to form desmosine. 37629 ChEBI 13941623 PubMed 14109938 PubMed 14109939 PubMed 5839176 PubMed AA0587 RESID Cross-link 4. 4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium RESID-systematic 6-[4-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine RESID-alternate desmosine RESID-name DiffAvg -58.15 DiffFormula C 0 H -16 N -3 O 0 DiffMono -58.134971 FormalCharge 1+ Formula C 24 H 32 N 5 O 4 MassAvg 454.55 MassMono 454.244881 Origin K, K, K, K Source natural TermSpec none MOD:00912 MOD:01425 PSI-MOD MOD:01934 isodesmosine A protein modification that effectively cross-links four L-lysine residues to form isodesmosine. 37629 ChEBI 13941623 PubMed 14109938 PubMed 14109939 PubMed 5839176 PubMed AA0588 RESID Cross-link 4. 2-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium RESID-systematic 6-[2-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine RESID-alternate isodesmosine RESID-name DiffAvg -58.15 DiffFormula C 0 H -16 N -3 O 0 DiffMono -58.134971 FormalCharge 1+ Formula C 24 H 32 N 5 O 4 MassAvg 454.55 MassMono 454.244881 Origin K, K, K, K Source natural TermSpec none MOD:00912 MOD:01425 PSI-MOD MOD:01935 O-glucosyl-L-hydroxylysine modification from RESID 22045808 PubMed AA0589 RESID (D-glucopyranosyl)oxy-L-lysine RESID-systematic O-glucosyl-L-hydroxylysine RESID-name DiffAvg 178.14 DiffFormula C 6 H 10 N 0 O 6 DiffMono 178.047738 Formula C 12 H 22 N 2 O 7 MassAvg 306.32 MassMono 306.142701 Origin K Source natural TermSpec none MOD:01047 PSI-MOD MOD:01936 N6-oleoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-oleoyl-L-lysine. 20942504 PubMed AA0590 RESID (2S)-2-amino-6-([(9Z)-octadec-9-enoyl]amino)hexanoic acid RESID-systematic N6-[(9Z)-1-oxo-9-octadecenyl]lysine RESID-alternate N6-oleoyl-L-lysine RESID-name DiffAvg 264.45 DiffFormula C 18 H 32 N 0 O 1 DiffMono 264.245316 Formula C 24 H 44 N 2 O 2 MassAvg 392.63 MassMono 392.340279 Origin K Source natural TermSpec none MOD:01875 PSI-MOD MOD:01937 N-palmitoyl-L-methionine A protein modification that effectively converts an L-methionine residue to N-palmitoyl-L-methionine. 20942504 PubMed AA0591 RESID (2S)-2-(hexadecanoylamino)-4-(methylsulfanyl)butanoic acid RESID-systematic 2-(hexadecanamido)-4-(methylsulfanyl)butanoic acid RESID-alternate LIPID N-palmitoyl methionine UniProt-feature N-(1-oxohexadecyl)methionine RESID-alternate N-palmitoyl-L-methionine RESID-name DiffAvg 238.41 DiffFormula C 16 H 30 N 0 O 1 S 0 DiffMono 238.229666 Formula C 21 H 40 N 1 O 2 S 1 MassAvg 370.62 MassMono 370.277976 Origin M Source natural TermSpec N-term MOD:00913 MOD:01685 PSI-MOD MOD:01938 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asn) A protein modification that crosslinks an asparagine and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the release of ammonia. AA0592#ASN RESID Cross-link 2. (2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid RESID-systematic 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid RESID-name aspartimide cysteine RESID-alternate DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 S 0 DiffMono -17.026549 Formula C 7 H 8 N 2 O 3 S 1 MassAvg 200.21 MassMono 200.025563 Origin C, N Source natural TermSpec none MOD:00903 MOD:01945 PSI-MOD MOD:01939 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asp) A protein modification that crosslinks an aspartic acid and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the loss of a water molecule. AA0592#ASP RESID Cross-link 2. (2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid RESID-systematic 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid RESID-name aspartimide cysteine RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 7 H 8 N 2 O 3 S 1 MassAvg 200.21 MassMono 200.025563 Origin C, D Source natural TermSpec none MOD:00904 MOD:01945 PSI-MOD MOD:01940 2-(2-aminosuccinimidyl)pentanedioic acid (Asn) A protein modification that crosslinks an asparagine and the following glutamic acid residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the release of ammonia. AA0593#ASN RESID Cross-link 2. (4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid RESID-systematic 2-(2-aminosuccinimidyl)pentanedioic acid RESID-name aspartimide glutamic acid RESID-alternate DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 9 H 10 N 2 O 5 MassAvg 226.19 MassMono 226.058971 Origin E, N Source natural TermSpec none MOD:00903 MOD:01946 PSI-MOD MOD:01941 2-(2-aminosuccinimidyl)pentanedioic acid (Asp) A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the loss of a water molecule. AA0593#ASP RESID Cross-link 2. (4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid RESID-systematic 2-(2-aminosuccinimidyl)pentanedioic acid RESID-name aspartimide glutamic acid RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 9 H 10 N 2 O 5 MassAvg 226.19 MassMono 226.058971 Origin D, E Source natural TermSpec none MOD:00904 MOD:01946 PSI-MOD MOD:01942 D-aspartic acid A protein modification that effectively converts a source amino acid residue to D-aspartic acid. 48094 ChEBI 9384562 PubMed AA0190 RESID (2R)-2-aminobutanedioic acid RESID-systematic 2-azanylbutanedioic acid RESID-alternate aminosuccinic acid RESID-alternate D-aspartic acid RESID-name DiffAvg none DiffFormula none DiffMono none Formula C 4 H 5 N 1 O 3 MassAvg 115.09 MassMono 115.026943 Origin X Source artifactual TermSpec none MOD:00664 MOD:00859 PSI-MOD MOD:01943 pyrrolidione ring crosslinked residues A protein modification that crosslinks two adjacent residues by formation of a pyrrolidione ring. 18688235 PubMed MOD:00033 PSI-MOD MOD:01944 2-aminosuccinimide ring crosslinked residues A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following residue. 18688235 PubMed Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. PSI-MOD-slim DiffAvg none DiffFormula none DiffMono none Formula none MassAvg none MassMono none Origin X Source hypothetical TermSpec none MOD:00033 MOD:00859 PSI-MOD MOD:01945 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid A protein modification that forms (2-aminosuccinimidyl)-3-sulfanylpropanoic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following cysteine residue. 18688235 PubMed Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. DiffAvg none DiffFormula none DiffMono none Formula C 6 H 6 N 2 O 3 MassAvg 154.13 MassMono 154.037842 Origin C, X Source hypothetical TermSpec none MOD:00905 MOD:01944 PSI-MOD MOD:01946 2-(2-aminosuccinimidyl)pentanedioic acid A protein modification that forms (2-aminosuccinimidyl)pentanedioicacid by crosslinking either an aspartic acid residue or an asparagine residue with the following glutamic acid\n residue. 18688235 PubMed Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. DiffAvg none DiffFormula none DiffMono none Formula C 6 H 6 N 2 O 3 MassAvg 154.13 MassMono 154.037842 Origin E, X Source hypothetical TermSpec none MOD:00906 MOD:01944 PSI-MOD MOD:01947 O-(L-isoaspartyl)-L-threonine (cross-link) A protein modification that effectively cross-links an L-threonine residue and an L-aspartic acid residue with an ester bond to form O-(L-isoaspartyl)-L-threonine. 17157318 PubMed 8706862 PubMed AA0525#TDX RESID Cross-link 2. (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid RESID-systematic (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid RESID-alternate CROSSLNK isoaspartyl threonine ester (Thr-Asp) UniProt-feature O(beta)-(beta-aspartyl)threonine RESID-alternate O-(L-isoaspartyl)-L-threonine RESID-name O3-(isoaspartyl)-threonine RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 DiffMono -18.010565 Formula C 8 H 10 N 2 O 4 MassAvg 198.18 MassMono 198.064057 Origin D, T Source natural TermSpec none MOD:00885 MOD:00904 MOD:00954 MOD:01978 PSI-MOD MOD:01948 labionin A protein modification that effectively cross-links an L-cysteine residue and two L-serine residues by a thioether bond and a carbon-carbon bond to form labionin. 20082397 PubMed AA0594 RESID Cross-link 3. (2S,4S)-2,4-diamino-2-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)methyl]pentanedioic acid RESID-systematic (2S,4S,8R)-2,4,8-triamino-4-carboxy-6-thianonanedioic acid RESID-alternate (2S,4S,8R)-labionin RESID-alternate labionin RESID-name DiffAvg -36.03 DiffFormula C 0 H -4 N 0 O -2 S 0 DiffMono -36.021129 Formula C 9 H 11 N 3 O 3 S 1 MassAvg 241.26 MassMono 241.052112 Origin C, S, S Source natural TermSpec none MOD:00916 MOD:01993 PSI-MOD MOD:01949 coelenterazine A protein modification that effectively cross-links a phenylalanine and two tyrosine residues to form coelenterazine. 2311 ChEBI 10830969 PubMed 11572972 PubMed 19833098 PubMed AA0595 RESID Cross-link 3. 8-benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one RESID-systematic coelenterazine RESID-name Oplophorus luciferin RESID-alternate DiffAvg -50.06 DiffFormula C -1 H -6 N 0 O -2 DiffMono -50.036779 Formula C 26 H 21 N 3 O 3 MassAvg 423.47 MassMono 423.158292 Origin F, Y, Y Source hypothetical TermSpec N-term MOD:00033 MOD:00914 MOD:00919 PSI-MOD MOD:01950 L-isoglutamyl histamine A protein modification that effectively converts an L-glutamine residue to L-isoglutamyl histamine. 23022564 PubMed AA0596 RESID (2S)-2-amino-5-([2-(1H-imidazol-5-yl)ethyl]amino)-5-oxopentanoic acid RESID-systematic (gamma-glutamyl)histamine RESID-alternate L-isoglutamyl histamine RESID-name DiffAvg 94.12 DiffFormula C 5 H 6 N 2 O 0 DiffMono 94.053098 Formula C 10 H 14 N 4 O 2 MassAvg 222.25 MassMono 222.111676 Origin Q Source natural TermSpec none MOD:00907 PSI-MOD MOD:01951 O-(L-isoglutamyl)-L-serine (Gln-Ser) A protein modification that effectively crosslinks an L-glutamine residue and an L-serine residue by an ester bond and releasing ammonia to form O-(L-isoglutamyl)-L-serine. 17051152 PubMed AA0597#QSX RESID Cross-link 2. (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid RESID-systematic O(beta)-(gamma-glutamyl)serine RESID-alternate O-(L-isoglutamyl)-L-serine RESID-name O3-(isoglutamyl)-serine RESID-alternate DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 8 H 10 N 2 O 4 MassAvg 198.18 MassMono 198.064057 Origin Q, S Source natural TermSpec none MOD:00907 MOD:00946 MOD:01977 PSI-MOD MOD:01952 O-(L-isoglutamyl)-L-threonine (cross-link) A protein modification that effectively cross-links an L-threonine residue and an L-glutamine residue with an ester bond releasing ammonia to form O-(L-isoglutamyl)-L-threonine. 17051152 PubMed AA0536#TQX RESID Cross-link 2. (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid RESID-systematic (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid RESID-alternate 5-(threon-O3-yl)glutamate RESID-alternate O(beta)-(gamma-glutamyl)threonine RESID-alternate O-(L-isoglutamyl)-L-threonine RESID-name O3-(isoglutamyl)threonine RESID-alternate DiffAvg -17.03 DiffFormula C 0 H -3 N -1 O 0 DiffMono -17.026549 Formula C 9 H 12 N 2 O 4 MassAvg 212.20 MassMono 212.079707 Origin Q, T Source natural TermSpec none MOD:00885 MOD:00907 MOD:01979 PSI-MOD MOD:01953 tetrakis-L-cysteinyl tetrairon octanitrosyl A protein modification that effectively converts four L-cysteine residues and a four-iron cluster to tetrakis-L-cysteinyl tetrairon octanitrosyl. 21182249 PubMed AA0599 RESID Cross-link 4. DiffAvg 459.40 DiffFormula C 0 Fe 4 H -4 N 8 O 8 S 0 DiffMono 459.692359 Formula C 12 Fe 4 H 16 N 12 O 12 S 4 MassAvg 871.95 MassMono 871.729098 Origin C, C, C, C Source hypothetical TermSpec none MOD:00738 MOD:00905 PSI-MOD MOD:01954 dehydroalanine (Sec) A protein modification that effectively converts an L-selenocysteine residue to dehydroalanine. 17123 ChEBI 10220322 PubMed 12781460 PubMed 1547888 PubMed 1815586 PubMed 20805503 PubMed 21420488 PubMed 22031445 PubMed 2914619 PubMed 7947813 PubMed 8239649 PubMed AA0181 RESID 2,3-didehydroalanine RESID-alternate 2-aminoacrylic acid RESID-alternate 2-aminopropenoic acid RESID-systematic 4-methylidene-imidazole-5-one (MIO) active site RESID-alternate anhydroserine RESID-alternate dehydroalanine RESID-name Dha RESID-alternate DiffAvg -80.99 DiffFormula C 0 H -2 N 0 O 0 Se -1 DiffMono -81.932171 Formula C 3 H 3 N 1 O 1 MassAvg 69.06 MassMono 69.021464 Origin U Source natural TermSpec none MOD:01158 MOD:01168 PSI-MOD MOD:01955 L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide modification from RESID 21499260 PubMed AA0600 RESID Cross-link 7. 4Mn-Ca-5O cluster RESID-alternate L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide RESID-name mu2-alaninato-1kappaO(1),3kappaO(1')-mu2-aspartato-1kappaO(4),5kappaO(4')-mu2-aspartato-2kappaO(4),3kappaO(4')-mu2-glutamato-3kappaO(5),4kappaO(5')-mu2-glutamato-4kappaO(5),5kappaO(5')-mu-glutamato-2kappaO(5)-mu-histidino-2kappaN(tau)-mu4-oxido-1:2:4:5kappa(4)O-tri-mu3-oxido-1:2:3kappa(3)O;1:3:4kappa(3)O;2:3:4kappa(3)O;mu-oxido-4:5kappa(2)O-calciumtetramanganese RESID-systematic photosystem II catalytic cluster RESID-alternate DiffAvg 333.78 DiffFormula C 0 Ca 1 H -6 Mn 4 N 0 O 5 DiffMono 333.642394 Formula C 32 Ca 1 H 38 Mn 4 N 9 O 23 MassAvg 1176.53 MassMono 1175.922825 Origin A, D, D, E, E, E, H Source natural TermSpec C-term MOD:00740 MOD:00901 MOD:00904 MOD:00906 MOD:00909 MOD:01482 PSI-MOD MOD:01956 (3R)-3-hydroxy-L-arginine A protein modification that effectively converts an L-arginine residue to (3R)-3-hydroxy-L-arginine. 10094780 PubMed 23103944 PubMed 786730 PubMed AA0601 RESID (2S,3R)-2-amino-5-[(diaminomethylidene)amino]-3-hydroxypentanoic acid RESID-systematic (3R)-3-hydroxy-L-arginine RESID-name 2-amino-5-(carbamimidamido)-3-hydroxypentanoic acid [tautomer] RESID-alternate 2-amino-5-[(aminoiminomethyl)amino]-3-hydroxypentanoic acid [tautomer] RESID-alternate 2-amino-5-guanidino-3-hydroxypentanoic acid RESID-alternate beta-hydroxyarginine RESID-alternate C(beta)-hydroxyarginine RESID-alternate MOD_RES (3R)-3-hydroxyarginine UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 6 H 12 N 4 O 2 MassAvg 172.19 MassMono 172.096026 Origin R Source natural TermSpec none MOD:00682 PSI-MOD MOD:01957 2-hydroxyproline A protein modification that effectively converts an L-proline residue to 2-hydroxyproline. 23385463 PubMed AA0602 RESID (2R)-2-hydroxypyrrolidine-2-carboxylic acid RESID-systematic 2-hydroxyproline RESID-name 2-oxidanylpyrrolidine-2-carboxylic acid RESID-alternate alpha-hydroxyproline RESID-alternate DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 DiffMono 15.994915 Formula C 5 H 7 N 1 O 2 MassAvg 113.12 MassMono 113.047678 Origin P Source hypothetical TermSpec none MOD:01024 PSI-MOD MOD:01958 bis-L-cysteinyl bisglutathion-S-yl diiron disulfide A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bisglutathion-S-yl diiron disulfide. 17121859 PubMed AA0603 RESID Cross-link 2. bis-L-cysteinyl bisglutathion-S-yl diiron disulfide RESID-name di-mu-sulfido-bis(cysteinato)-1kappaS,2kappaS-bis(glutathionato)-1kappaS,2kappaS-diiron RESID-systematic mitochondrial glutaredoxin 2 dimer iron-sulfur cluster RESID-alternate plant glutaredoxin C1 dimer iron-sulfur cluster RESID-alternate DiffAvg 786.42 DiffFormula C 20 Fe 2 H 30 N 6 O 12 S 4 DiffMono 785.950329 Formula C 26 Fe 2 H 40 N 8 O 14 S 6 MassAvg 992.70 MassMono 991.968699 Origin C, C Source natural TermSpec none MOD:00739 MOD:00905 PSI-MOD MOD:01959 tris-L-cysteinyl L-glutamato tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-glutamic acid and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamato tetrairon tetrasulfide. 21167158 PubMed AA0604 RESID Cross-link 4. tris-L-cysteinyl L-glutamato tetrairon tetrasulfide RESID-name tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutamato-4kappaO(5),4kappaO(5')-tetrairon RESID-systematic DiffAvg 347.59 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.596734 Formula C 14 Fe 4 H 18 N 4 O 6 S 7 MassAvg 786.12 MassMono 785.666881 Origin C, C, C, E Source natural TermSpec none MOD:00739 MOD:00905 MOD:00906 PSI-MOD MOD:01960 tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-glutamine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide. 11796730 PubMed AA0605 RESID Cross-link 4. METAL Iron-sulfur (4Fe-4S) UniProt-feature tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide RESID-name tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutaminato-4kappaN(5)-tetrairon RESID-systematic DiffAvg 347.59 DiffFormula C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono 347.596734 Formula C 14 Fe 4 H 19 N 5 O 5 S 7 MassAvg 785.14 MassMono 784.682866 Origin C, C, C, Q Source natural TermSpec none MOD:00739 MOD:00905 MOD:00907 PSI-MOD MOD:01961 O-(L-isoglutamyl)-L-threonine (THR) OBSOLETE because redundant and identical to MOD:01785. Remap to MOD:01785. 16618936 PubMed 17051152 PubMed 17687277 PubMed 18555071 PubMed AA0536#THR RESID (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid RESID-systematic (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid RESID-alternate 5-(threon-O3-yl)glutamate RESID-alternate O(beta)-(gamma-glutamyl)threonine RESID-alternate O-(L-isoglutamyl)-L-threonine RESID-name O3-(isoglutamyl)threonine RESID-alternate DiffAvg 129.12 DiffFormula C 5 H 7 N 1 O 3 DiffMono 129.042593 Formula C 9 H 14 N 2 O 5 MassAvg 230.22 MassMono 230.090272 Origin T Source natural TermSpec none 1 PSI-MOD MOD:01962 N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine. 12186869 PubMed 19236052 PubMed AA0606 RESID (2S)-2-amino-4-[(2,4-diacetylamino-2,4,6-trideoxy-beta-D-glucopyranosyl)amino]-4-oxobutanoic acid RESID-systematic DABA RESID-alternate DATDH RESID-alternate DiNAcBac RESID-alternate N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine RESID-name N4-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-asparagine RESID-alternate N4-[N,N-diacetylbacillosaminyl]asparagine RESID-alternate N4-[N2,N4-diacetylbacillosaminyl]asparagine RESID-alternate DiffAvg 228.25 DiffFormula C 10 H 16 N 2 O 4 DiffMono 228.111007 Formula C 14 H 22 N 4 O 6 MassAvg 342.35 MassMono 342.153934 Origin N Source natural TermSpec none MOD:00160 PSI-MOD MOD:01963 O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine. 23030644 PubMed AA0607 RESID (2S)-2-amino-4-[(2,4-diacetamido-2,4,6-trideoxy-beta-D-glucopyranosyl)oxy]propanoic acid RESID-systematic DABA RESID-alternate DATDH RESID-alternate DiNAcBac RESID-alternate O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine RESID-name O-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-serine RESID-alternate O-[N,N-diacetylbacillosaminyl]serine RESID-alternate O-[N2,N4-diacetylbacillosaminyl]serine RESID-alternate DiffAvg 228.25 DiffFormula C 10 H 16 N 2 O 4 DiffMono 228.111007 Formula C 13 H 21 N 3 O 6 MassAvg 315.33 MassMono 315.143035 Origin S Source natural TermSpec none MOD:00002 PSI-MOD MOD:01964 O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine A protein modification that effectively converts an L-serine residue to O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine. 17804791 PubMed AA0608 RESID (2S)-2-amino-3-[(2-acetamido-4-glycerylamino-2,4,6-trideoxy-D-glucopyranosyl)oxy]propanoic acid RESID-systematic GATDH RESID-alternate O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucopyranosyl)-L-serine RESID-alternate O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine RESID-name O-(N2-acetyl-N4-glycerylbacillosaminyl)-L-serine RESID-alternate DiffAvg 274.27 DiffFormula C 11 H 18 N 2 O 6 DiffMono 274.116486 Formula C 14 H 23 N 3 O 8 MassAvg 361.35 MassMono 361.148515 Origin S Source natural TermSpec none MOD:00002 PSI-MOD MOD:01965 2xC(13),3x(2)H labeled N6-acetyl-L-lysine A protein modification that effectively converts an L-lysine residue to 2xC(13),3x(2)H labeled N6-acetyl-L-lysine. 18688235 PubMed Acetate labeling reagent (K) (heavy form, +5amu) PSI-MOD-alternate COFRADIC heavy acetyl 13C2 2H3 PSI-MOD-alternate DiffAvg 47.04 DiffFormula (13)C 2 (1)H -1 (2)H 3 O 1 DiffMono 47.036105 Formula (12)C 6 (13)C 2 (1)H 11 (2)H 3 N 2 O 2 MassAvg 175.13 MassMono 175.131068 Origin K Source artifact TermSpec none MOD:00064 MOD:01428 MOD:01431 PSI-MOD MOD:01966 L-methionine (R)-sulfoxide OBSOLETE because redundant and identical to MOD:00720. Remap to MOD:00720. 45764 ChEBI 21406390 PubMed 22116028 PubMed 23911929 PubMed AA0581 RESID (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid RESID-systematic L-methionine (R)-S-oxide RESID-alternate L-methionine (R)-sulfoxide RESID-name MOD_RES Methionine (R)-sulfoxide UniProt-feature DiffAvg 16.00 DiffFormula C 0 H 0 N 0 O 1 S 0 DiffMono 15.994915 Formula C 5 H 9 N 1 O 2 S 1 MassAvg 147.19 MassMono 147.035400 Origin M Source natural TermSpec none 1 PSI-MOD MOD:01967 omega-N-(N-acetylamino)glucosyl-L-arginine A protein modification that effectively converts an L-arginine residue to omega-N-(N-acetylamino)glucosyl-L-arginine. 23955153 PubMed AA0609 RESID (2S)-2-amino-5-[(amino[(2-N-acetylamino-2-deoxy-D-glucopyranosyl)amino]methylidene)amino]pentanoic acid RESID-systematic N(omega)-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine RESID-alternate N(omega)-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine RESID-alternate N(omega)-(2-N-acetylaminoglucosyl)arginine RESID-alternate NG-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine RESID-alternate NG-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine RESID-alternate NG-(2-N-acetylaminoglucosyl)arginine RESID-alternate omega-N-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine RESID-alternate omega-N-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine RESID-alternate omega-N-(2-N-acetylaminoglucosyl)arginine RESID-alternate omega-N-(N-acetylamino)glucosyl-L-arginine RESID-name DiffAvg 203.19 DiffFormula C 8 H 13 N 1 O 5 DiffMono 203.079373 Formula C 14 H 25 N 5 O 6 MassAvg 359.38 MassMono 359.180484 Origin R Source natural TermSpec none MOD:00448 MOD:01980 PSI-MOD MOD:01968 (2R,3R,2'R)-3-methyllanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2R,3R,2'R)-3-methyllanthionine. 23314913 PubMed AA0610 RESID Cross-link 2. (2R,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid RESID-systematic (2R,3R,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid RESID-alternate (2R,3R,2'R)-3-methyllanthionine RESID-name (2R,3R,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid RESID-alternate (2R,3R,6R)-3-methyllanthionine RESID-alternate 2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid RESID-alternate 3-methyl-L,L-lanthionine RESID-alternate cysteine-3-L-butyrine thioether RESID-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 7 H 10 N 2 O 2 S 1 MassAvg 186.23 MassMono 186.046299 Origin C, T Source natural TermSpec none MOD:01981 PSI-MOD MOD:01969 S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine A protein modification that effectively converts an L-cysteine residue to S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine. 9398217 PubMed AA0611 RESID (2S)-2-amino-5-([(2R)-1-([2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-oxoethyl]amino)-1-oxo-3-sulfanylpropan-2-yl]amino)-5-oxopentanoic acid RESID-systematic ACT_SITE S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine intermediate UniProt-feature S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine RESID-name S-(glutathion-1-yl)-L-cysteine RESID-alternate DiffAvg 289.31 DiffFormula C 10 H 15 N 3 O 5 S 1 DiffMono 289.073242 Formula C 13 H 20 N 4 O 6 S 2 MassAvg 392.44 MassMono 392.082426 Origin C Source natural TermSpec none MOD:00860 MOD:00905 PSI-MOD MOD:01970 5-glutamyl glutamic acid A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl glutamic acid, forming an isopeptide bond with a free glutamic acid. 10747868 PubMed 15525938 PubMed 1680872 PubMed 23434852 PubMed AA0612 RESID 450 UniMod (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanedioic acid RESID-systematic (2S)-2-[(4S)-4-amino-4-carboxybutanamido]pentanedioic acid RESID-alternate 2-([4-azanyl-4-carboxybutanoyl]azanyl)pentanedioic acid RESID-alternate 5-glutamyl glutamic acid RESID-name gamma-glutamylglutamate RESID-alternate Glu UniMod-interim isoglutamyl glutamic acid RESID-alternate isoglutamyl monoglutamic acid RESID-alternate MOD_RES 5-glutamyl glutamate UniProt-feature monoglutamyl UniMod-description N alpha -(gamma-Glutamyl)-Glu DeltaMass-label N-(gamma-L-glutamyl)-L-glutamic acid RESID-alternate DiffAvg 129.12 DiffFormula C 5 H 7 N 1 O 3 DiffMono 129.042593 Formula C 10 H 14 N 2 O 6 MassAvg 258.23 MassMono 258.085186 Origin E Source natural TermSpec none MOD:00207 PSI-MOD MOD:01971 5-glutamyl N2-ornithine A protein modification that effectively converts an L-glutamic acid residue to N2-ornithine. 23434852 PubMed AA0613 RESID (2S)-5-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanoic acid RESID-alternate (2S)-5-amino-2-[(4S)-4-amino-4-carboxybutanamido]pentanoic acid RESID-systematic 4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-ketovaleric acid RESID-alternate 4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-oxopentanoic acid RESID-alternate 5-glutamyl N2-ornithine RESID-name gamma-glutamylornithine RESID-alternate MOD_RES 5-glutamyl N2-ornithine UniProt-feature N2-(gamma-glutamyl)ornithine RESID-alternate N2-(L-isoglutamyl)-L-ornithine RESID-alternate DiffAvg 114.15 DiffFormula C 5 H 10 N 2 O 1 DiffMono 114.079313 Formula C 10 H 17 N 3 O 4 MassAvg 243.26 MassMono 243.121906 Origin E Source hypothetical TermSpec none MOD:00674 MOD:00906 PSI-MOD MOD:01972 5-glutamyl coenzyme A thioester A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl coenzyme A thioester. 16253988 PubMed 20977214 PubMed 7915164 PubMed AA0614 RESID (2S)-2-amino-5-(2-[([3-([(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanoyl]-amino)-propanoyl]-amino)-ethyl]-sulfanyl)-5-oxopentanoic acid RESID-alternate (2S)-2-amino-5-([2-(3-[(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanamido]-propanamido)-ethyl]-sulfanyl)-5-oxopentanoic acid RESID-systematic 5-glutamyl 4-[(3'-phospho-adenosyl-5'-diphosphoryl)oxy]pantetheine thioester RESID-alternate 5-glutamyl coenzyme A thioester RESID-name 5-glutamyl coenzyme A thioester intermediate UniProt-feature DiffAvg 749.52 DiffFormula C 21 H 34 N 7 O 15 P 3 S 1 DiffMono 749.104644 Formula C 26 H 41 N 8 O 18 P 3 S 1 MassAvg 878.63 MassMono 878.147237 Origin E Source natural TermSpec none MOD:00860 MOD:00861 MOD:00906 PSI-MOD MOD:01973 N6-(3-phosphoglyceryl)-L-lysine A protein modification that effectively converts an L-lysine residue to N6-(3-phosphoglyceryl)-L-lysine. 23908237 PubMed AA0615 RESID (2S)-2-amino-6-([(2R)-2-hydroxy-3-(phosphonooxy)propanoyl]amino)hexanoic acid RESID-alternate (2S)-2-amino-6-[(2R)-2-hydroxy-3-(phosphonooxy)propanamido]hexanoic acid RESID-systematic 3-phosphoglyceryl-lysine RESID-alternate N6-(3-phosphoglyceryl)-L-lysine RESID-name DiffAvg 168.04 DiffFormula C 3 H 5 N 0 O 6 P 1 DiffMono 167.982375 Formula C 9 H 17 N 2 O 7 P 1 MassAvg 296.22 MassMono 296.077338 Origin K Source natural TermSpec none MOD:00861 MOD:01875 PSI-MOD MOD:01974 S-methyl-L-methionine A protein modification that effectively converts an L-methionine residue to S-methyl-L-methionine. 17728 ChEBI 23532849 PubMed AA0616 RESID (2S)-2-amino-4-(dimethylsulfonio)butanoate RESID-alternate (3S)-(3-amino-3-carboxypropyl)dimethylsulfanium RESID-systematic [(3S)-3-amino-3-carboxypropyl](dimethyl)sulfonium RESID-alternate S-methyl-L-methionine RESID-name S-methylmethionine RESID-alternate S-methylmethioninium RESID-alternate vitamin U RESID-alternate DiffAvg 15.03 DiffFormula C 1 H 3 N 0 O 0 S 0 DiffMono 15.022927 FormalCharge 1+ Formula C 6 H 12 N 1 O 1 S 1 MassAvg 146.23 MassMono 146.063411 Origin M Source natural TermSpec none MOD:00716 PSI-MOD MOD:01975 S-poly(3-hydroxybutyrate)-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-(poly-3-hydroxybutyrate)-L-cysteine. 19711985 PubMed 9888824 PubMed AA0617 RESID (alpha)-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-(omega)-[(3R)-3-hydroxybutanoyl]-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy) RESID-systematic S-poly(3-hydroxybutanoate)cysteine RESID-alternate S-poly(3-hydroxybutanoic acid)cysteine RESID-alternate S-poly(3-hydroxybutyrate)-L-cysteine RESID-name S-poly(3-hydroxybutyrate)cysteine RESID-alternate S-poly(3-hydroxybutyric acid)cysteine RESID-alternate S-poly(beta-hydroxybutyrate)cysteine RESID-alternate S-poly[(R)-3-hydroxybutyrate]cysteine RESID-alternate DiffAvg 172.18 DiffFormula C 8 H 12 N 0 O 4 S 0 DiffMono 172.073559 Formula C 11 H 17 N 1 O 5 S 1 MassAvg 275.32 MassMono 275.082744 Origin C Source natural TermSpec none MOD:00672 MOD:00905 PSI-MOD MOD:01976 O3-(poly-3-hydroxybutyrate)-L-serine A protein modification that effectively converts an L-serine residue to O3-(poly-3-hydroxybutyrate)-L-serine. 17659252 PubMed 20004640 PubMed AA0618 RESID PSI-MOD-slim (2S)-2-amino-3-[([(3R)-3-hydroxybutanoyl]oxy)-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)]propanoic acid RESID-systematic O3-(poly-3-hydroxybutyrate)-L-serine RESID-name O3-poly(3-hydroxybutanoate)serine RESID-alternate O3-poly(3-hydroxybutanoic acid)serine RESID-alternate O3-poly(3-hydroxybutyrate)serine RESID-alternate O3-poly(3-hydroxybutyric acid)serine RESID-alternate O3-poly(beta-hydroxybutyrate)serine RESID-alternate O3-poly[(R)-3-hydroxybutyrate]serine RESID-alternate DiffAvg 172.18 DiffFormula C 8 H 12 N 0 O 4 DiffMono 172.073559 Formula C 11 H 17 N 1 O 6 MassAvg 259.26 MassMono 259.105587 Origin S Source natural TermSpec none MOD:00671 MOD:00916 PSI-MOD MOD:01977 O-(L-isoglutamyl)-L-serine A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-serine residue by an ester bond to form O-(L-isoglutamyl)-L-serine. 17051152 PubMed AA0597 RESID Cross-link 2. (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid RESID-systematic O(beta)-(gamma-glutamyl)serine RESID-alternate O-(L-isoglutamyl)-L-serine RESID-name O3-(isoglutamyl)-serine RESID-alternate DiffAvg none DiffFormula none DiffMono none Formula C 8 H 10 N 2 O 4 MassAvg 198.18 MassMono 198.064057 Origin S, X Source natural TermSpec none MOD:00859 MOD:00885 MOD:00916 PSI-MOD MOD:01978 O-(L-isoaspartyl)-L-threonine A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using either free L-asparagine and releasing ammonia or using a peptidyl L-aspartic acid residue and releasing water. 8706862 PubMed AA0525 RESID This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid RESID-systematic (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid RESID-alternate O(beta)-(beta-aspartyl)threonine RESID-alternate O-(L-isoaspartyl)-L-threonine RESID-name O3-(isoaspartyl)-threonine RESID-alternate DiffAvg none DiffFormula none DiffMono none Formula C 8 H 12 N 2 O 5 MassAvg 216.19 MassMono 216.074621 Origin T, X Source natural TermSpec none MOD:00859 MOD:00917 PSI-MOD MOD:01979 O-(L-isoglutamyl)-L-threonine A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia, or using a peptidyl L-glutamine and releasing ammonia. 8706862 PubMed AA0536 RESID This is not an ester cross-link of peptides [JSG]. (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid RESID-systematic (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid RESID-alternate 5-(threon-O3-yl)glutamate RESID-alternate O(beta)-(gamma-glutamyl)threonine RESID-alternate O-(L-isoglutamyl)-L-threonine RESID-name O3-(isoglutamyl)threonine RESID-alternate DiffAvg none DiffFormula none DiffMono none Formula C 9 H 14 N 2 O 5 MassAvg 230.22 MassMono 230.090272 Origin T, X Source hypothetical TermSpec none MOD:00859 MOD:00917 PSI-MOD MOD:01980 omega-N-glycosyl-L-arginine A protein modification that effectively converts an L-arginine residue to N4-glycosyl-arginine. 15279557 PubMed 8521968 PubMed 9536051 PubMed AA0327 RESID 41#R UniMod (2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid RESID-systematic Hex PSI-MS-label Hexose UniMod-description NG-beta-D-glucosylarginine RESID-alternate omega-N-(beta-D-glucosyl)-L-arginine RESID-alternate omega-N-glucosyl-L-arginine RESID-name omega-N-glycosyl-L-arginine RESID-alternate Origin R Source natural TermSpec none MOD:00006 MOD:00902 PSI-MOD MOD:01981 3-methyllanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 3-methyllanthionine with unresolved stereospecificity. 18688235 PubMed Cross-link 2. 2,6-diamino-3-methyl-4-thiaheptanedioic acid PSI-MOD-alternate 2-amino-3-([2-amino-2-carboxyethyl]sulfanyl)butanoic acid PSI-MOD-alternate 2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid PSI-MOD-alternate 2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid PSI-MOD-alternate 3-methyllanthionine PSI-MOD-alternate cysteine-3-L-butyrine thioether PSI-MOD-alternate DiffAvg -18.02 DiffFormula C 0 H -2 N 0 O -1 S 0 DiffMono -18.010565 Formula C 7 H 10 N 2 O 2 S 1 MassAvg 186.23 MassMono 186.046299 Origin C, T Source natural TermSpec none MOD:00917 MOD:00954 MOD:01993 PSI-MOD MOD:01982 N,N,N-trimethylglycine modification from RESID 17750 ChEBI 23818633 PubMed 23978223 PubMed AA0619 RESID PSI-MOD-slim (trimethylammonio)ethanoic acid RESID-alternate 1-carboxy-N,N,N-trimethylmethanazanium RESID-alternate 2-trimethylammonioacetate RESID-alternate betaine RESID-alternate carboxy-N,N,N-trimethylmethanaminium RESID-systematic carboxymethyl-trimethylazanium RESID-alternate glycine betaine RESID-alternate MOD_RES N,N,N-trimethylglycine UniProt-feature N,N,N-trimethylglycine cation RESID-alternate N,N,N-trimethylglycinium RESID-alternate N2Me3+Gly PSI-MOD-label DiffAvg 43.09 DiffFormula C 3 H 7 N 0 O 0 DiffMono 43.054775 Formula C 5 H 11 N 1 O 1 MassAvg 101.15 MassMono 101.084064 Origin G Source natural TermSpec N-term MOD:00714 MOD:01698 PSI-MOD MOD:01983 N,N-dimethylglycine A protein modification that effectively converts a glycine residue to N,N-dimethyllglycine. 17724 ChEBI 23818633 PubMed 23978223 PubMed AA0620 RESID (dimethylamino)ethanoic acid RESID-systematic 1-carboxy-N,N-dimethylaminomethane RESID-alternate 2-(dimethylamino)acetic acid RESID-alternate MOD_RES N,N-dimethylglycine UniProt-feature vitamin B16 RESID-alternate DiffAvg 28.05 DiffFormula C 2 H 4 N 0 O 0 DiffMono 28.031300 Formula C 4 H 8 N 1 O 1 MassAvg 86.11 MassMono 86.060589 Origin G Source natural TermSpec N-term MOD:00714 MOD:01686 PSI-MOD MOD:01984 2-(L-cystein-S-yl)-L-alanine A protein modification that effectively cross-links an L-cysteine residue and an L-alanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-alanine. 21526839 PubMed AA0621 RESID Cross-link 2. (2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid RESID-systematic (2R,5R)-2,5-diamino-5-methyl-4-thiahexanedioic acid RESID-alternate alpha-(L-cystein-S-yl)-L-alanine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 2 S 1 MassAvg 172.20 MassMono 172.030649 Origin A, C Source natural TermSpec none MOD:00901 MOD:01992 PSI-MOD MOD:01985 2-(L-cystein-S-yl)-D-asparagine A protein modification that effectively cross-links an L-cysteine residue and an L-asparagine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-asparagine. 21786372 PubMed AA0622 RESID Cross-link 2. (2S)-2,4-diamino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-4-oxobutanoic acid RESID-systematic alpha-(L-cystein-S-yl)-D-asparagine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 7 H 9 N 3 O 3 S 1 MassAvg 215.23 MassMono 215.036462 Origin C, N Source natural TermSpec none MOD:00664 MOD:00903 MOD:01992 PSI-MOD MOD:01986 2-(L-cystein-S-yl)-L-serine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-serine. 21526839 PubMed AA0623 RESID Cross-link 2. (2R)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid RESID-systematic (2R,5R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 3 S 1 MassAvg 188.20 MassMono 188.025563 Origin C, S Source natural TermSpec none MOD:00916 MOD:01992 PSI-MOD MOD:01987 2-(L-cystein-S-yl)-D-serine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-serine. 21786372 PubMed AA0624 RESID Cross-link 2. (2R,5S)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid RESID-alternate (2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid RESID-systematic DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 6 H 8 N 2 O 3 S 1 MassAvg 188.20 MassMono 188.025563 Origin C, S Source natural TermSpec none MOD:00664 MOD:00916 MOD:01992 PSI-MOD MOD:01988 2-(L-cystein-S-yl)-L-threonine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-threonine. 21526839 PubMed AA0625 RESID Cross-link 2. (2R,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid RESID-systematic (2R,5R,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid RESID-alternate alpha-(L-cystein-S-yl)-L-threonine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 7 H 10 N 2 O 3 S 1 MassAvg 202.23 MassMono 202.041213 Origin C, T Source natural TermSpec none MOD:00917 MOD:01992 PSI-MOD MOD:01989 2-(L-cystein-S-yl)-D-tyrosine A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-tyrosine. 21526839 PubMed AA0626 RESID Cross-link 2. (2R,5S)-2,5-diamino-5-carboxyl-6-(hydroxyphenyl)-4-thiahexanoic acid RESID-alternate (2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid RESID-systematic alpha-(L-cystein-S-yl)-D-tyrosine RESID-alternate DiffAvg -2.02 DiffFormula C 0 H -2 N 0 O 0 S 0 DiffMono -2.015650 Formula C 12 H 12 N 2 O 3 S 1 MassAvg 264.30 MassMono 264.056863 Origin C, Y Source natural TermSpec none MOD:00664 MOD:00919 MOD:01992 PSI-MOD MOD:01990 protonated glycine (glycinium) residue A protein modification that effectively converts a glycine residue to a glycinium (protonated glycine). 64723 ChEBI 18688235 PubMed PSI-MOD-slim DiffAvg 1.01 DiffFormula C 0 H 1 N 0 O 0 DiffMono 1.007276 FormalCharge 1+ Formula C 2 H 5 N 1 O 1 MassAvg 59.07 MassMono 59.036565 Origin G Source natural TermSpec N-term MOD:00908 MOD:01700 PSI-MOD MOD:01991 N,N,N-trimethylglycine (from glycinium) A protein modification that effectively converts a glycinium (protonated glycine) residue to an N,N,N-trimethylglycine. 17750 ChEBI 23818633 PubMed 23978223 PubMed AA0619 RESID For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Gly process (MOD:01982) accounts for both protonation and trimethylation. PSI-MOD-slim N2Me3Gly PSI-MOD-label DiffAvg 42.08 DiffFormula C 3 H 6 N 0 O 0 DiffMono 42.046402 FormalCharge 1+ Formula C 5 H 11 N 1 O 1 MassAvg 101.15 MassMono 101.083515 Origin MOD:01990 Source natural TermSpec N-term MOD:01687 derives_from MOD:019900 PSI-MOD MOD:01992 alpha-carbon thioether crosslinked residues A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the alpha-carbon of another amino acid residue. 18688235 PubMed MOD:00687 PSI-MOD MOD:01993 beta-carbon thioether crosslinked residues A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the beta-carbon of another amino acid residue. 18688235 PubMed These are typical lanthionine-like crosslinks. MOD:00687 PSI-MOD MOD:01994 N1'-formyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to N1'-formyl-L-tryptophan. 18688235 PubMed This modifications has not been reported as commonly encountered [JSG]. N1'FoTrp PSI-MOD-label DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 12 H 10 N 2 O 2 MassAvg 214.22 MassMono 214.074228 Origin W Source hypothetical TermSpec none MOD:01106 PSI-MOD MOD:01995 N2-formyl-L-tryptophan A protein modification that effectively converts an L-tryptophan residue to N2-formyl-L-tryptophan. 18688235 PubMed This modifications has not been reported as commonly encountered [JSG]. N2FoTrp PSI-MOD-label DiffAvg 28.01 DiffFormula C 1 H 0 N 0 O 1 DiffMono 27.994915 Formula C 12 H 11 N 2 O 2 MassAvg 215.23 MassMono 215.082053 Origin W Source hypothetical TermSpec N-term MOD:01106 PSI-MOD MOD:01996 butanoylated residue A protein modification that effectively replaces a hydrogen atom with an butanoyl group. 18688235 PubMed Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). ButRes PSI-MOD-label Butyryl UniMod-interim butyrylation PSI-MOD-alternate DiffAvg 70.09 DiffFormula C 4 H 6 O 1 DiffMono 70.041865 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:00649 PSI-MOD MOD:01997 N-butanoylated residue A protein modification that effectively replaces a residue amino or imino hydrogen with a butanoyl group. 18688235 PubMed N-butanoyl PSI-MOD-alternate N-butanoylation PSI-MOD-alternate N-butyryl PSI-MOD-alternate N-butyrylation PSI-MOD-alternate NButRes PSI-MOD-label DiffAvg 70.09 DiffFormula C 4 H 6 N 0 O 1 DiffMono 70.041865 Formula none MassAvg none MassMono none Origin X Source none TermSpec none MOD:01996 PSI-MOD MOD:01998 alpha-amino butanoylated residue A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a butanoyl group. 18688235 PubMed N2ButRes PSI-MOD-label DiffAvg 70.09 DiffFormula C 4 H 6 N 0 O 1 DiffMono 70.041865 Formula none MassAvg none MassMono none Origin X Source artifact TermSpec N-term MOD:01997 PSI-MOD MOD:01999 N6-(11-cis)-retinylidene-L-lysine A protein modification that effectively converts an L-lysine residue to N6-retinylidene-(11-cis)-L-lysine. 18688235 PubMed (2S)-2-amino-6-[(2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid PSI-MOD-alternate DiffAvg 266.43 DiffFormula C 20 H 26 N 0 O 0 DiffMono 266.203451 Formula C 26 H 38 N 2 O 1 MassAvg 394.60 MassMono 394.298414 Origin K Source natural TermSpec none MOD:02000 PSI-MOD MOD:02000 N6-retinylidene-L-lysine (unspecified geometric isomer) A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine (unspecified geometric isomer). 18688235 PubMed (2S)-2-amino-6-[3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid PSI-MOD-alternate DiffAvg 266.43 DiffFormula C 20 H 26 N 0 O 0 DiffMono 266.203451 Formula C 26 H 38 N 2 O 1 MassAvg 394.60 MassMono 394.298414 Origin K Source natural TermSpec none MOD:00912 PSI-MOD contains contains 'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'. 18688235 PubMed The inverse relationship to "part of". 1 PSI-MOD derives_from derives from 'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'. 18688235 PubMed 1 PSI-MOD has_functional_parent has functional parent 'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification. 18688235 PubMed This relationship indicates that the formula and mass of the child are not inherited from the mass of the parent. 1 PSI-MOD part_of part of 'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'. 18688235 PubMed 1 PSI-MOD