format-version: 1.2 date: 30:05:2014 00:48 saved-by: John S. Garavelli auto-generated-by: FormulaOBO.PL subsetdef: PSI-MOD-slim "subset of protein modifications" synonymtypedef: DeltaMass-label "Label from MS DeltaMass" EXACT synonymtypedef: OMSSA-label "Short label from OMSSA" EXACT synonymtypedef: PSI-MOD-alternate "Alternate name curated by PSI-MOD" EXACT synonymtypedef: PSI-MOD-label "Short label curated by PSI-MOD" EXACT synonymtypedef: PSI-MS-label "Agreed label from MS community" RELATED synonymtypedef: RESID-alternate "Alternate name from RESID" EXACT synonymtypedef: RESID-misnomer "Misnomer tagged alternate name from RESID" RELATED synonymtypedef: RESID-name "Name from RESID" EXACT synonymtypedef: RESID-systematic "Systematic name from RESID" EXACT synonymtypedef: UniMod-alternate "Alternate name from UniMod" RELATED synonymtypedef: UniMod-description "Description (full_name) from UniMod" RELATED synonymtypedef: UniMod-interim "Interim label from UniMod" RELATED synonymtypedef: UniProt-feature "Protein feature description from UniProtKB" EXACT default-namespace: PSI-MOD remark: PSI-MOD version: 1.013.0 remark: RESID release: 75.00 remark: ISO-8601 date: 2014-01-28 14:22Z remark: Annotation note 1 - "[PSI-MOD:ref]" has been replaced by PubMed:18688235. remark: Annotation note 2 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol "#" and a 3 or 4 character label. When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate, on secondary modifications that do not change the nature of the primary modification, or on a combination of a primary and one or more secondary modifications on the same residue, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the special tag "#var". remark: Annotation note 3 - When an entry in the UniMod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the UniMod cross-reference followed by a hash symbol and an amino acid code, "N-term" or "C-term". remark: Annotation note 4 - The elemental formulas are in strict alphabetical order, not in CAS ("C" and "H" first) order. Isotope numbers are in parentheses before the element symbol, and an element should not occur in a formula both with and without an isotope number. In difference formulas, counts can be zero or negative. remark: Annotation note 5 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for other elements without isotope indicators in the formulas. remark: Annotation note 6 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked. remark: Annotation note 7 - The synonym cross-reference "MOD:old name" has been replaced by "MOD:alternate name". remark: Annotation note 8 - The DeltaMass listings for free amino acids have been removed. Most UniMod entries that have not been "approved" have by general agreement not been incorporated unless there has been a request for a specific term by a PRIDE submitter. remark: Annotation note 9 - The Open Mass Spectrometry Search Algorithm, OMSSA, enumerated list of modifications are being incorporated. The string values are synonyms with the synonymtypedef "OMSSA-label", and their integer values (which are supposed to be stable) are definition cross-references. [Term] id: MOD:00000 name: protein modification def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModRes" EXACT PSI-MOD-label [] [Term] id: MOD:00001 name: alkylated residue def: "A protein modification that effectively replaces a hydrogen atom with an alkyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "AlkylRes" EXACT PSI-MOD-label [] xref: Source: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00002 name: O-glycosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-glycosylserine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OGlycoSer" EXACT PSI-MOD-label [] xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00396 ! O-glycosylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00003 name: UniMod def: "Entry from UniMod." [PubMed:18688235] comment: This term is for organizational use only and should not be assigned. [JSG] xref: Source: "none" is_a: MOD:00032 ! uncategorized protein modification [Term] id: MOD:00004 name: artifact def: "Artifact entry from UniMod - OBSOLETE because organizational use is no longer required." [PubMed:18688235] is_obsolete: true [Term] id: MOD:00005 name: O-glycosyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OGlycoThr" EXACT PSI-MOD-label [] xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00396 ! O-glycosylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00006 name: N-glycosylated residue def: "A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NGlycoRes" EXACT PSI-MOD-label [] xref: Source: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00007 name: selenium substitution for sulfur def: "A protein modification that effectively substitutes a selenium atom for a sulfur atom." [PubMed:12148805, UniMod:162] synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label [] synonym: "Se(S)Res" EXACT PSI-MOD-label [] synonym: "Selenium replaces sulphur" RELATED UniMod-description [] xref: DiffAvg: "46.91" xref: DiffFormula: "C 0 H 0 N 0 O 0 S -1 Se 1" xref: DiffMono: "47.944450" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00745 ! selenium containing residue [Term] id: MOD:00008 name: common def: "Entry from UniMod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required." [PubMed:18688235] is_obsolete: true [Term] id: MOD:00009 name: natural residue def: "A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue." [PubMed:6692818, RESID:AA0000] subset: PSI-MOD-slim synonym: "alpha-amino acid" EXACT RESID-name [] synonym: "Res" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "natural" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00010 name: L-alanine residue def: "A protein modification that effectively converts a source amino acid residue to an L-alanine." [ChEBI:29948, DeltaMass:0, PubMed:6692818, RESID:AA0001] subset: PSI-MOD-slim synonym: "(2S)-2-aminopropanoic acid" EXACT RESID-systematic [] synonym: "2-aminopropionic acid" EXACT RESID-alternate [] synonym: "2-azanylpropanoic acid" EXACT RESID-alternate [] synonym: "Ala" EXACT PSI-MOD-label [] synonym: "alpha-alanine" EXACT RESID-alternate [] synonym: "alpha-aminopropionic acid" EXACT RESID-alternate [] synonym: "L-alanine" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 3 H 5 N 1 O 1" xref: MassAvg: "71.08" xref: MassMono: "71.037114" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00570 ! residues isobaric at 71.037114 Da is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00011 name: L-arginine residue def: "A protein modification that effectively converts a source amino acid residue to an L-arginine." [ChEBI:29952, DeltaMass:0, PubMed:518876, PubMed:6692818, RESID:AA0002] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid" EXACT RESID-systematic [] synonym: "2-amino-5-(carbamimidamido)pentanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-amino-5-guanidinopentanoic acid" EXACT RESID-alternate [] synonym: "2-amino-5-guanidinovaleric acid" EXACT RESID-alternate [] synonym: "2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-delta-guanidinovaleric acid" EXACT RESID-alternate [] synonym: "Arg" EXACT PSI-MOD-label [] synonym: "L-arginine" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 12 N 4 O 1" xref: MassAvg: "156.19" xref: MassMono: "156.101111" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00012 name: L-asparagine residue def: "A protein modification that effectively converts a source amino acid residue to an L-asparagine." [ChEBI:29956, DeltaMass:0, PubMed:15736973, PubMed:5681232, PubMed:6692818, PubMed:9789001, RESID:AA0003] subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-butanediamic acid" EXACT RESID-systematic [] synonym: "2,4-bis(azanyl)-4-oxobutanoic acid" EXACT RESID-alternate [] synonym: "2,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-carbamoylpropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-4-butanediamic acid" EXACT RESID-alternate [] synonym: "2-aminosuccinamic acid" EXACT RESID-alternate [] synonym: "2-aminosuccinic acid 4-amide" EXACT RESID-alternate [] synonym: "alpha-amino-beta-carbamylpropionic acid" EXACT RESID-alternate [] synonym: "alpha-aminosuccinamic acid" EXACT RESID-alternate [] synonym: "Asn" EXACT PSI-MOD-label [] synonym: "aspartic acid 4-amide" EXACT RESID-alternate [] synonym: "aspartic acid beta-amide" EXACT RESID-alternate [] synonym: "beta-asparagine" EXACT RESID-alternate [] synonym: "L-asparagine" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 4 H 6 N 2 O 2" xref: MassAvg: "114.10" xref: MassMono: "114.042927" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00013 name: L-aspartic acid residue def: "A protein modification that effectively converts a source amino acid residue to an L-aspartic acid." [ChEBI:29958, DeltaMass:0, PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, RESID:AA0004] subset: PSI-MOD-slim synonym: "(2S)-2-aminobutanedioic acid" EXACT RESID-systematic [] synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] synonym: "aminosuccinic acid" EXACT RESID-alternate [] synonym: "Asp" EXACT PSI-MOD-label [] synonym: "L-aspartic acid" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 4 H 5 N 1 O 3" xref: MassAvg: "115.09" xref: MassMono: "115.026943" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00014 name: L-cysteine residue def: "A protein modification that effectively converts a source amino acid residue to an L-cysteine." [ChEBI:29950, DeltaMass:0, PubMed:1310545, PubMed:15790858, PubMed:3447159, PubMed:6692818, PubMed:7338899, RESID:AA0005] comment: From DeltaMass: Average Mass: 121. subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "(R)-cysteine" EXACT RESID-alternate [] synonym: "2-amino-3-mercaptopropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-mercaptopropionic acid" EXACT RESID-alternate [] synonym: "2-azanyl-3-sulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "3-mercapto-L-alanine" EXACT RESID-alternate [] synonym: "alpha-amino-beta-mercaptopropanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-beta-mercaptopropionic acid" EXACT RESID-alternate [] synonym: "alpha-amino-beta-thiolpropionic acid" EXACT RESID-alternate [] synonym: "beta-mercaptoalanine" EXACT RESID-alternate [] synonym: "Cys" EXACT PSI-MOD-label [] synonym: "Cysteine (C, Cys)" EXACT DeltaMass-label [] synonym: "half-cystine" EXACT RESID-alternate [] synonym: "L-(+)-cysteine" EXACT RESID-alternate [] synonym: "L-cysteine" EXACT RESID-name [] synonym: "thioserine" EXACT RESID-alternate [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0" xref: DiffMono: "0.000000" xref: Formula: "C 3 H 5 N 1 O 1 S 1" xref: MassAvg: "103.14" xref: MassMono: "103.009185" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00015 name: L-glutamic acid residue def: "A protein modification that effectively converts a source amino acid residue to an L-glutamic acid." [ChEBI:29972, DeltaMass:0, PubMed:1881881, PubMed:4565668, PubMed:4922541, PubMed:6692818, PubMed:9326660, PubMed:957425, RESID:AA0006] subset: PSI-MOD-slim synonym: "(2S)-2-aminopentanedioic acid" EXACT RESID-systematic [] synonym: "1-aminopropane-1,3-dicarboxylic acid" EXACT RESID-alternate [] synonym: "2-aminoglutaric acid" EXACT RESID-alternate [] synonym: "2-azanylpentanedioic acid" EXACT RESID-alternate [] synonym: "alpha-aminoglutaric acid" EXACT RESID-alternate [] synonym: "Glu" EXACT PSI-MOD-label [] synonym: "glutaminic acid" EXACT RESID-alternate [] synonym: "L-glutamic acid" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00016 name: L-glutamine residue def: "A protein modification that effectively converts a source amino acid residue to an L-glutamine." [ChEBI:30011, DeltaMass:0, PubMed:3340166, PubMed:6692818, PubMed:9342308, RESID:AA0007] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-pentanediamic acid" EXACT RESID-systematic [] synonym: "2,5-bis(azanyl)-5-oxopentanoic acid" EXACT RESID-alternate [] synonym: "2,5-diamino-5-oxopentanoic acid" EXACT RESID-alternate [] synonym: "2-amino-4-carbamoylbutanoic acid" EXACT RESID-alternate [] synonym: "2-aminoglutaramic acid" EXACT RESID-alternate [] synonym: "alpha-amino-gamma-carbamylbutyric acid" EXACT RESID-alternate [] synonym: "Gln" EXACT PSI-MOD-label [] synonym: "glutamic acid 5-amide" EXACT RESID-alternate [] synonym: "glutamic acid gamma-amide" EXACT RESID-alternate [] synonym: "glutamide" EXACT RESID-alternate [] synonym: "L-glutamine" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 5 H 8 N 2 O 2" xref: MassAvg: "128.13" xref: MassMono: "128.058578" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00894 ! residues isobaric at 128.058578 Da is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00017 name: glycine residue def: "A protein modification that effectively converts a source amino acid residue to a glycine." [ChEBI:29947, DeltaMass:0, PubMed:1310545, PubMed:6692818, RESID:AA0008] subset: PSI-MOD-slim synonym: "aminoacetic acid" EXACT RESID-alternate [] synonym: "aminoethanoic acid" EXACT RESID-systematic [] synonym: "azanylethanoic acid" EXACT RESID-alternate [] synonym: "Gly" EXACT PSI-MOD-label [] synonym: "glycine" EXACT RESID-name [] synonym: "glycocoll" EXACT RESID-alternate [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 2 H 3 N 1 O 1" xref: MassAvg: "57.05" xref: MassMono: "57.021464" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00018 name: L-histidine residue def: "A protein modification that effectively converts a source amino acid residue to an L-histidine." [ChEBI:29979, DeltaMass:0, PubMed:14342316, PubMed:2722967, PubMed:512, PubMed:5460889, PubMed:6129252, PubMed:6692818, PubMed:6876174, RESID:AA0009] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-azanyl-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate [] synonym: "2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "4-(2-amino-2-carboxyethyl)imidazole" EXACT RESID-alternate [] synonym: "alpha-amino-beta-(4-imidazole)propionic acid" EXACT RESID-alternate [] synonym: "glyoxaline-5-alanine" EXACT RESID-alternate [] synonym: "His" EXACT PSI-MOD-label [] synonym: "L-histidine" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 7 N 3 O 1" xref: MassAvg: "137.14" xref: MassMono: "137.058912" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00019 name: L-isoleucine residue def: "A protein modification that effectively converts a source amino acid residue to an L-isoleucine." [ChEBI:30009, DeltaMass:0, PubMed:6692818, RESID:AA0010] subset: PSI-MOD-slim synonym: "(2S,3S)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate [] synonym: "3-methyl-norvaline" EXACT RESID-alternate [] synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate [] synonym: "Ile" EXACT PSI-MOD-label [] synonym: "Isoleucyl" EXACT DeltaMass-label [] synonym: "L-erythro-isoleucine" EXACT RESID-alternate [] synonym: "L-isoleucine" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 11 N 1 O 1" xref: MassAvg: "113.16" xref: MassMono: "113.084064" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00306 ! residues isobaric at 113.084064 Da is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00020 name: L-leucine residue def: "A protein modification that effectively converts a source amino acid residue to an L-leucine." [ChEBI:30006, DeltaMass:0, PubMed:11478885, PubMed:6692818, RESID:AA0011] subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-methylpentanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-4-methylpentanoic acid" EXACT RESID-alternate [] synonym: "4-methyl-norvaline" EXACT RESID-alternate [] synonym: "alpha-amino-gamma-methylvaleric acid" EXACT RESID-alternate [] synonym: "alpha-aminoisocaproic acid" EXACT RESID-alternate [] synonym: "L-leucine" EXACT RESID-name [] synonym: "Leu" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 11 N 1 O 1" xref: MassAvg: "113.16" xref: MassMono: "113.084064" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00306 ! residues isobaric at 113.084064 Da is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00021 name: L-lysine residue def: "A protein modification that effectively converts a source amino acid residue to L-lysine." [ChEBI:29967, DeltaMass:0, PubMed:3106962, PubMed:6120171, PubMed:6692818, RESID:AA0012] subset: PSI-MOD-slim synonym: "(2S)-2,6-diaminohexanoic acid" EXACT RESID-systematic [] synonym: "2,6-bis(azanyl)hexanoic acid" EXACT RESID-alternate [] synonym: "6-amino-L-norleucine" EXACT RESID-alternate [] synonym: "ACT_SITE Schiff-base intermediate with substrate" EXACT UniProt-feature [] synonym: "alpha,epsilon-diaminocaproic acid" EXACT RESID-alternate [] synonym: "L-lysine" EXACT RESID-name [] synonym: "Lys" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 12 N 2 O 1" xref: MassAvg: "128.18" xref: MassMono: "128.094963" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00893 ! residues isobaric at 128.0-128.1 is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00022 name: L-methionine residue def: "A protein modification that effectively converts a source amino acid residue to L-methionine." [ChEBI:29983, DeltaMass:0, PubMed:6411710, PubMed:6692818, RESID:AA0013] comment: From DeltaMass: Average Mass: 149 subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-amino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] synonym: "2-amino-4-(methylthio)butyric acid" EXACT RESID-alternate [] synonym: "2-azanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-gamma-methylmercaptobutyric acid" EXACT RESID-alternate [] synonym: "alpha-amino-gamma-methylthiobutyric acid" EXACT RESID-alternate [] synonym: "gamma-methylthio-alpha-aminobutyric acid" EXACT RESID-alternate [] synonym: "L-(-)-methionine" EXACT RESID-alternate [] synonym: "L-methionine" EXACT RESID-name [] synonym: "Met" EXACT PSI-MOD-label [] synonym: "S-methyl-L-homocysteine" EXACT RESID-alternate [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0" xref: DiffMono: "0.000000" xref: Formula: "C 5 H 9 N 1 O 1 S 1" xref: MassAvg: "131.19" xref: MassMono: "131.040485" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00023 name: L-phenylalanine residue def: "A protein modification that effectively converts a source amino acid residue to L-phenylalanine." [ChEBI:29997, DeltaMass:0, PubMed:6692818, RESID:AA0014] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-phenylpropanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-phenylpropanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-beta-phenylpropionic acid" EXACT RESID-alternate [] synonym: "L-phenylalanine" EXACT RESID-name [] synonym: "Phe" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 9 H 9 N 1 O 1" xref: MassAvg: "147.18" xref: MassMono: "147.068414" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00024 name: L-proline residue def: "A protein modification that effectively converts a source amino acid residue to L-proline." [ChEBI:30017, DeltaMass:0, PubMed:6692818, PubMed:8547259, RESID:AA0015] subset: PSI-MOD-slim synonym: "(2S)-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic [] synonym: "L-proline" EXACT RESID-name [] synonym: "Pro" EXACT PSI-MOD-label [] synonym: "pyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 5 H 7 N 1 O 1" xref: MassAvg: "97.12" xref: MassMono: "97.052764" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00025 name: L-serine residue def: "A protein modification that effectively converts a source amino acid residue to L-serine." [ChEBI:29999, DeltaMass:0, PubMed:4399050, PubMed:6692818, RESID:AA0016] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-hydroxypropanoic acid" EXACT RESID-alternate [] synonym: "3-hydroxy-L-alanine" EXACT RESID-alternate [] synonym: "alpha-amino-beta-hydroxypropionic acid" EXACT RESID-alternate [] synonym: "beta-hydroxyalanine" EXACT RESID-alternate [] synonym: "L-serine" EXACT RESID-name [] synonym: "Ser" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 3 H 5 N 1 O 2" xref: MassAvg: "87.08" xref: MassMono: "87.032028" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00026 name: L-threonine residue def: "A protein modification that effectively converts a source amino acid residue to L-threonine." [ChEBI:30013, DeltaMass:0, PubMed:2989287, PubMed:6692818, RESID:AA0017] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-hydroxybutanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-hydroxybutanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-beta-hydroxybutyric acid" EXACT RESID-alternate [] synonym: "beta-methylserine" EXACT RESID-alternate [] synonym: "L-threo-threonine" EXACT RESID-alternate [] synonym: "L-threonine" EXACT RESID-name [] synonym: "Thr" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 4 H 7 N 1 O 2" xref: MassAvg: "101.10" xref: MassMono: "101.047678" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00027 name: L-tryptophan residue def: "A protein modification that effectively converts a source amino acid residue to L-tryptophan." [ChEBI:29954, DeltaMass:0, PubMed:2059637, PubMed:6692818, PubMed:9324768, RESID:AA0018] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-beta-(3-indolyl)propionoic acid" EXACT RESID-alternate [] synonym: "beta(3-indolyl)alanine" EXACT RESID-alternate [] synonym: "L-tryptophan" EXACT RESID-name [] synonym: "Trp" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 11 H 10 N 2 O 1" xref: MassAvg: "186.21" xref: MassMono: "186.079313" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00028 name: L-tyrosine residue def: "A protein modification that effectively converts a source amino acid residue to L-tyrosine." [ChEBI:29975, DeltaMass:0, PubMed:2190093, PubMed:2542938, PubMed:5550972, PubMed:6061414, PubMed:6120171, PubMed:6692818, RESID:AA0019] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-beta-(para-hydroxyphenyl)propionic acid" EXACT RESID-alternate [] synonym: "L-tyrosine" EXACT RESID-name [] synonym: "p-tyrosine" EXACT RESID-alternate [] synonym: "para-hydroxyphenylalanine" EXACT RESID-alternate [] synonym: "Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 9 H 9 N 1 O 2" xref: MassAvg: "163.18" xref: MassMono: "163.063329" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00029 name: L-valine residue def: "A protein modification that effectively converts a source amino acid residue to an L-valine." [ChEBI:30015, DeltaMass:0, PubMed:6692818, RESID:AA0020] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-methylbutanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-methylbutanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-beta-methylbutyric acid" EXACT RESID-alternate [] synonym: "alpha-aminoisovaleric acid" EXACT RESID-alternate [] synonym: "L-valine" EXACT RESID-name [] synonym: "Val" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 5 H 9 N 1 O 1" xref: MassAvg: "99.13" xref: MassMono: "99.068414" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01441 ! natural, standard, encoded residue [Term] id: MOD:00030 name: N-formyl-L-methionine residue def: "A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification." [ChEBI:33718, OMSSA:22, PubMed:10825024, PubMed:11152118, PubMed:2165784, PubMed:3042771, PubMed:8758896, RESID:AA0021#FMET, UniMod:107#N-term] subset: PSI-MOD-slim synonym: "(2S)-2-formylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-formamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "2-formylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] synonym: "2-formylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "Addition of N-formyl met" RELATED UniMod-description [] synonym: "fMet" EXACT PSI-MOD-label [] synonym: "FormylMet" RELATED PSI-MS-label [] synonym: "MOD_RES N-formylmethionine" EXACT UniProt-feature [] synonym: "N-formyl-L-methionine" EXACT RESID-name [] synonym: "N-formylated L-methionine" EXACT PSI-MOD-alternate [] synonym: "nformylmet" EXACT OMSSA-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 10 N 1 O 2 S 1" xref: MassAvg: "160.21" xref: MassMono: "160.043225" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00409 ! N-formylated residue is_a: MOD:00868 ! natural, non-standard encoded residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:00031 name: L-selenocysteine residue def: "A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification." [ChEBI:30000, PubMed:10523135, PubMed:1066676, PubMed:2037562, PubMed:2963330, PubMed:4734725, PubMed:6076213, PubMed:6217842, PubMed:6714945, RESID:AA0022] subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-selanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-selanylpropanoic acid" EXACT RESID-alternate [] synonym: "3-selenylalanine" EXACT RESID-alternate [] synonym: "L-selenocysteine" EXACT RESID-name [] synonym: "NON_STD Selenocysteine" EXACT UniProt-feature [] synonym: "Sec" EXACT PSI-MOD-label [] synonym: "SeCys" EXACT RESID-alternate [] synonym: "selenium cysteine" EXACT RESID-alternate [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0 Se 0" xref: DiffMono: "0.000000" xref: Formula: "C 3 H 5 N 1 O 1 Se 1" xref: MassAvg: "150.05" xref: MassMono: "150.953635" xref: Origin: "U" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00745 ! selenium containing residue is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:00868 ! natural, non-standard encoded residue [Term] id: MOD:00032 name: uncategorized protein modification def: "A protein modification that is not chemically categorized." [PubMed:18688235] comment: This term is for organizational use only and should not be assigned. [JSG] xref: Source: "none" is_a: MOD:00000 ! protein modification [Term] id: MOD:00033 name: crosslinked residues def: "A protein modification that crosslinks two or more amino acid residues with covalent bonds." [PubMed:18688235] comment: The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site. subset: PSI-MOD-slim synonym: "XLNK-Res-Res" EXACT PSI-MOD-label [] xref: Source: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00034 name: L-cystine (cross-link) def: "A protein modification that effectively cross-links two L-cysteine residues to form L-cystine." [ChEBI:16283, DeltaMass:0, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025#CYS2] comment: Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765. subset: PSI-MOD-slim synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer [] synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate [] synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate [] synonym: "3,3'-dithiodialanine" EXACT RESID-alternate [] synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate [] synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate [] synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate [] synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate [] synonym: "Cys2" EXACT PSI-MOD-label [] synonym: "Cystine ((Cys)2)" EXACT DeltaMass-label [] synonym: "dicysteine" EXACT RESID-alternate [] synonym: "DISULFID" EXACT UniProt-feature [] synonym: "DISULFID Interchain" EXACT UniProt-feature [] synonym: "L-cystine" EXACT RESID-name [] synonym: "XLNK-SCys-SCys" EXACT PSI-MOD-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 6 H 8 N 2 O 2 S 2" xref: MassAvg: "204.26" xref: MassMono: "204.002720" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00689 ! disulfide crosslinked residues [Term] id: MOD:00035 name: (2S,3R)-3-hydroxyasparagine def: "A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine." [PubMed:11823643, PubMed:2820791, RESID:AA0026] subset: PSI-MOD-slim synonym: "(2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid" EXACT RESID-alternate [] synonym: "(2S,3R)-2-amino-3-hydroxy-4-butanediamic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-3-hydroxyasparagine" EXACT RESID-name [] synonym: "(3R)3HyAsn" EXACT PSI-MOD-label [] synonym: "2-azanyl-3-hydroxy-4-butanediamic acid" EXACT RESID-alternate [] synonym: "erythro-beta-hydroxylated L-asparagine" EXACT PSI-MOD-alternate [] synonym: "L-erythro-beta-hydroxyasparagine" EXACT RESID-alternate [] synonym: "MOD_RES (3R)-3-hydroxyasparagine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 4 H 6 N 2 O 3" xref: MassAvg: "130.10" xref: MassMono: "130.037842" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01688 ! 3-hydroxy-L-asparagine [Term] id: MOD:00036 name: (2S,3R)-3-hydroxyaspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid." [OMSSA:59, PubMed:6572939, PubMed:6871167, PubMed:8355279, RESID:AA0027, UniMod:35#D] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-hydroxybutanedioic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-3-hydroxyaspartic acid" EXACT RESID-name [] synonym: "(3R)3HyAsp" EXACT PSI-MOD-label [] synonym: "2-amino-3-hydroxysuccinic acid" EXACT RESID-alternate [] synonym: "2-azanyl-3-hydroxybutanedioic acid" EXACT RESID-alternate [] synonym: "3-hydroxyaspartic acid" EXACT RESID-alternate [] synonym: "erythro-beta-hydroxylated L-aspartic acid" EXACT PSI-MOD-alternate [] synonym: "hydroxylationd" EXACT OMSSA-label [] synonym: "L-erythro-beta-hydroxyaspartic acid" EXACT RESID-alternate [] synonym: "MOD_RES (3R)-3-hydroxyaspartate" EXACT UniProt-feature [] synonym: "Oxidation" RELATED PSI-MS-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 4 H 5 N 1 O 4" xref: MassAvg: "131.09" xref: MassMono: "131.021858" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01926 ! 3-hydroxy-L-aspartic acid [Term] id: MOD:00037 name: 5-hydroxy-L-lysine def: "A protein modification that effectively converts an L-lysine residue to one of the diastereomeric 5-hydroxy-L-lysine residues." [ChEBI:60175, PubMed:18688235] subset: PSI-MOD-slim synonym: "5-hydroxylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "5HyLys" EXACT PSI-MOD-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 12 N 2 O 2" xref: MassAvg: "144.17" xref: MassMono: "144.089878" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01047 ! monohydroxylated lysine [Term] id: MOD:00038 name: 3-hydroxy-L-proline def: "A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline." [ChEBI:16889, PubMed:2400108, PubMed:3734192, PubMed:4343807, RESID:AA0029] subset: PSI-MOD-slim synonym: "(2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "3-hydroxy-L-proline" EXACT RESID-name [] synonym: "3-hydroxylated L-proline" EXACT PSI-MOD-alternate [] synonym: "3-trans-hydroxy-L-proline" EXACT RESID-alternate [] synonym: "3HyPro" EXACT PSI-MOD-label [] synonym: "beta-hydroxypyrrolidine-alpha-carboxylic acid" EXACT RESID-alternate [] synonym: "L-threo-3-hydroxyproline" EXACT RESID-alternate [] synonym: "MOD_RES 3-hydroxyproline" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 7 N 1 O 2" xref: MassAvg: "113.12" xref: MassMono: "113.047678" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01024 ! monohydroxylated proline [Term] id: MOD:00039 name: 4-hydroxy-L-proline def: "A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline" [ChEBI:18095, PubMed:11292863, PubMed:2400108, PubMed:3734192, RESID:AA0030] subset: PSI-MOD-slim synonym: "(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "4-hydroxy-L-proline" EXACT RESID-name [] synonym: "4-hydroxylated L-proline" EXACT PSI-MOD-alternate [] synonym: "4-hydroxyproline" EXACT RESID-alternate [] synonym: "4-trans-hydroxy-L-proline" EXACT RESID-alternate [] synonym: "4HyPro" EXACT PSI-MOD-label [] synonym: "gamma-hydroxypyrrolidine-alpha-carboxylic acid" EXACT RESID-alternate [] synonym: "L-threo-4-hydroxyproline" EXACT RESID-alternate [] synonym: "MOD_RES 4-hydroxyproline" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 7 N 1 O 2" xref: MassAvg: "113.12" xref: MassMono: "113.047678" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01024 ! monohydroxylated proline [Term] id: MOD:00040 name: 2-pyrrolidone-5-carboxylic acid (Gln) def: "A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid." [ChEBI:30652, DeltaMass:123, OMSSA:110, PubMed:10214721, PubMed:1836357, PubMed:26343, PubMed:3473473, RESID:AA0031#GLN, UniMod:28#Q] comment: DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1 subset: PSI-MOD-slim synonym: "(2S)-5-oxo-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic [] synonym: "2-oxopyrrolidine-5-carboxylic acid" EXACT RESID-alternate [] synonym: "2-pyrrolidone-5-carboxylic acid" EXACT RESID-name [] synonym: "5-oxoproline" EXACT RESID-alternate [] synonym: "5-oxopyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] synonym: "5-pyrrolidone-2-carboxylic acid" EXACT RESID-alternate [] synonym: "Gln->pyro-Glu" RELATED PSI-MS-label [] synonym: "MOD_RES Pyrrolidone carboxylic acid" EXACT UniProt-feature [] synonym: "N-pyrrolidone carboxyl (N terminus)" EXACT DeltaMass-label [] synonym: "ntermpeppyroq" EXACT OMSSA-label [] synonym: "PCA" EXACT RESID-alternate [] synonym: "PyrGlu(Gln)" EXACT PSI-MOD-label [] synonym: "Pyro-glu from Q" RELATED UniMod-description [] synonym: "pyroglutamic acid" EXACT RESID-alternate [] synonym: "Pyroglutamic Acid formed from Gln" EXACT DeltaMass-label [] synonym: "Pyroglutamyl" EXACT DeltaMass-label [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 5 H 6 N 1 O 2" xref: MassAvg: "112.11" xref: MassMono: "112.039853" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid is_a: MOD:01160 ! deaminated residue [Term] id: MOD:00041 name: L-gamma-carboxyglutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid." [DeltaMass:217, OMSSA:48, PubMed:10517147, PubMed:1807167, PubMed:3263814, PubMed:4528109, PubMed:7457858, PubMed:8135347, PubMed:8868490, PubMed:9188685, RESID:AA0032, UniMod:299#E] comment: DeltaMass has an incorrect formula C 6 H 7 N 5 O 1 (N and O reversed) with mass 173. subset: PSI-MOD-slim synonym: "(3S)-3-aminopropane-1,1,3-tricarboxylic acid" EXACT RESID-systematic [] synonym: "(3S)-3-azanylpropane-1,1,3-tricarboxylic acid" EXACT RESID-alternate [] synonym: "1-carboxyglutamic acid" RELATED RESID-misnomer [] synonym: "3-amino-1,1,3-propanetricarboxylic acid" EXACT RESID-alternate [] synonym: "3-azanylpropane-1,1,3-tricarboxylic acid" EXACT RESID-alternate [] synonym: "4-carboxyglutamic acid" EXACT RESID-alternate [] synonym: "4CbxGlu" EXACT PSI-MOD-label [] synonym: "Carboxy" RELATED PSI-MS-label [] synonym: "Carboxy" RELATED UniMod-interim [] synonym: "Carboxy Glutamyl" EXACT DeltaMass-label [] synonym: "Carboxylation" RELATED UniMod-description [] synonym: "gamma-carboxylated L-glutamic acid" EXACT PSI-MOD-alternate [] synonym: "gammacarboxyle" EXACT OMSSA-label [] synonym: "L-gamma-carboxyglutamic acid" EXACT RESID-name [] synonym: "MOD_RES 4-carboxyglutamate" EXACT UniProt-feature [] xref: DiffAvg: "44.01" xref: DiffFormula: "C 1 H 0 N 0 O 2" xref: DiffMono: "43.989829" xref: Formula: "C 6 H 7 N 1 O 5" xref: MassAvg: "173.12" xref: MassMono: "173.032422" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01152 ! carboxylated residue [Term] id: MOD:00042 name: L-aspartic 4-phosphoric anhydride def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride." [ChEBI:15836, PubMed:4357737, RESID:AA0033, UniMod:21#D] synonym: "(2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid" EXACT RESID-systematic [] synonym: "2-aminobutanedioic 4-phosphoric anhydride" EXACT RESID-alternate [] synonym: "2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid" EXACT RESID-alternate [] synonym: "4-oxo-O-phosphono-L-homoserine" EXACT RESID-alternate [] synonym: "4-phosphoaspartic acid" EXACT RESID-alternate [] synonym: "4-phosphorylated L-aspartatic acid" EXACT PSI-MOD-alternate [] synonym: "ACT_SITE 4-aspartylphosphate intermediate" EXACT UniProt-feature [] synonym: "beta-aspartyl phosphate" EXACT RESID-alternate [] synonym: "L-aspartic 4-phosphoric anhydride" EXACT RESID-name [] synonym: "MOD_RES 4-aspartylphosphate" EXACT UniProt-feature [] synonym: "PAsp" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "Phosphorylation" RELATED UniMod-description [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 4 H 6 N 1 O 6 P 1" xref: MassAvg: "195.07" xref: MassMono: "194.993274" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01455 ! O-phosphorylated residue [Term] id: MOD:00043 name: S-phospho-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine." [PubMed:3142516, PubMed:7961745, PubMed:8128219, RESID:AA0034, UniMod:21#C] synonym: "(2R)-2-amino-3-(phosphonosulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-(phosphonosulfanyl)propanoic acid" EXACT RESID-alternate [] synonym: "ACT_SITE Phosphocysteine intermediate" EXACT UniProt-feature [] synonym: "cysteine phosphate thioester" EXACT RESID-alternate [] synonym: "MOD_RES Phosphocysteine" EXACT UniProt-feature [] synonym: "PCys" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "Phosphorylation" RELATED UniMod-description [] synonym: "S-phospho-L-cysteine" EXACT RESID-name [] synonym: "S-phosphonocysteine" EXACT RESID-alternate [] synonym: "S-phosphorylated L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S3-phosphocysteine" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1 S 0" xref: DiffMono: "79.966331" xref: Formula: "C 3 H 6 N 1 O 4 P 1 S 1" xref: MassAvg: "183.12" xref: MassMono: "182.975515" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00696 ! phosphorylated residue is_a: MOD:00777 ! residues isobaric at 182.96-182.98 Da is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00044 name: 1'-phospho-L-histidine def: "A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine)." [PubMed:11038361, PubMed:5642389, PubMed:6692818, RESID:AA0035] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "1'-phospho-L-histidine" EXACT RESID-name [] synonym: "2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate [] synonym: "ACT_SITE Tele-phosphohistidine intermediate" EXACT UniProt-feature [] synonym: "histidine-3-phosphate" RELATED RESID-misnomer [] synonym: "histidine-N(epsilon)-phosphate" EXACT RESID-alternate [] synonym: "histidine-N1'-phosphate" EXACT RESID-alternate [] synonym: "MOD_RES Tele-phosphohistidine" EXACT UniProt-feature [] synonym: "N(tau)-phosphohistidine" EXACT RESID-alternate [] synonym: "N1-phosphonohistidine" EXACT RESID-alternate [] synonym: "NE2-phosphonohistidine" EXACT RESID-alternate [] synonym: "Ntau-phosphorylated L-histidine" EXACT PSI-MOD-alternate [] synonym: "NtPHis" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "Phosphorylation" RELATED UniMod-description [] synonym: "tele-phosphohistidine" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 6 H 8 N 3 O 4 P 1" xref: MassAvg: "217.12" xref: MassMono: "217.025242" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00890 ! phosphorylated L-histidine [Term] id: MOD:00045 name: 3'-phospho-L-histidine def: "A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine)." [PubMed:1549615, PubMed:5642389, PubMed:6692818, PubMed:7669763, PubMed:7803390, RESID:AA0036] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate [] synonym: "3'-phospho-L-histidine" EXACT RESID-name [] synonym: "ACT_SITE Pros-phosphohistidine intermediate" EXACT UniProt-feature [] synonym: "histidine-1-phosphate" RELATED RESID-misnomer [] synonym: "histidine-N(delta)-phosphate" EXACT RESID-alternate [] synonym: "histidine-N3'-phosphate" EXACT RESID-alternate [] synonym: "MOD_RES Pros-phosphohistidine" EXACT UniProt-feature [] synonym: "N(pi)-phosphohistidine" EXACT RESID-alternate [] synonym: "N3-phosphonohistidine" EXACT RESID-alternate [] synonym: "ND1-phosphonohistidine" EXACT RESID-alternate [] synonym: "Npi-phosphorylated L-histidine" EXACT PSI-MOD-alternate [] synonym: "NpPHis" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "Phosphorylation" RELATED UniMod-description [] synonym: "pros-phosphohistidine" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 6 H 8 N 3 O 4 P 1" xref: MassAvg: "217.12" xref: MassMono: "217.025242" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00890 ! phosphorylated L-histidine [Term] id: MOD:00046 name: O-phospho-L-serine def: "A protein modification that effectively converts an L-serine residue to O-phospho-L-serine." [ChEBI:15811, DeltaMass:0, OMSSA:6, PubMed:12923550, PubMed:4065410, PubMed:8061611, RESID:AA0037, UniMod:21#S] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(phosphonooxy)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-hydroxypropanoic acid 3-phosphate" EXACT RESID-alternate [] synonym: "2-azanyl-3-(phosphonooxy)propanoic acid" EXACT RESID-alternate [] synonym: "ACT_SITE Phosphoserine intermediate" EXACT UniProt-feature [] synonym: "MOD_RES Phosphoserine" EXACT UniProt-feature [] synonym: "O-phospho-L-serine" EXACT RESID-name [] synonym: "O-phosphonoserine" EXACT RESID-alternate [] synonym: "O-phosphorylated L-serine" EXACT PSI-MOD-alternate [] synonym: "O3-phosphoserine" EXACT RESID-alternate [] synonym: "OPSer" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "Phospho Seryl" EXACT DeltaMass-label [] synonym: "Phosphorylation" RELATED UniMod-description [] synonym: "phosphorylations" EXACT OMSSA-label [] synonym: "serine phosphate ester" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 3 H 6 N 1 O 5 P 1" xref: MassAvg: "167.06" xref: MassMono: "166.998359" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00771 ! residues isobaric at 166.98-167.00 Da is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01455 ! O-phosphorylated residue [Term] id: MOD:00047 name: O-phospho-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine." [ChEBI:21967, DeltaMass:0, OMSSA:7, PubMed:12923550, PubMed:7678926, RESID:AA0038, UniMod:21#T] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(phosphonooxy)butanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-hydroxybutanoic acid 3-phosphate" EXACT RESID-alternate [] synonym: "2-azanyl-3-(phosphonooxy)butanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES Phosphothreonine" EXACT UniProt-feature [] synonym: "O-phospho-L-threonine" EXACT RESID-name [] synonym: "O-phosphorylated L-threonine" EXACT PSI-MOD-alternate [] synonym: "O3-phosphothreonine" EXACT RESID-alternate [] synonym: "OPThr" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "Phospho Threonyl" EXACT DeltaMass-label [] synonym: "Phosphorylation" RELATED UniMod-description [] synonym: "phosphorylationt" EXACT OMSSA-label [] synonym: "threonine phosphate ester" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 4 H 8 N 1 O 5 P 1" xref: MassAvg: "181.08" xref: MassMono: "181.014009" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00773 ! residues isobaric at 181.00-181.02 Da is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01455 ! O-phosphorylated residue [Term] id: MOD:00048 name: O4'-phospho-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine." [DeltaMass:0, OMSSA:8, PubMed:10226369, PubMed:1725475, RESID:AA0039, UniMod:21#Y] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate" EXACT RESID-alternate [] synonym: "2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES Phosphotyrosine" EXACT UniProt-feature [] synonym: "O4'-phospho-L-tyrosine" EXACT RESID-name [] synonym: "O4'-phosphorylated L-tyrosine" EXACT PSI-MOD-alternate [] synonym: "O4-phosphotyrosine" EXACT RESID-alternate [] synonym: "OPTyr" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "Phospho Tyrosinyl" EXACT DeltaMass-label [] synonym: "Phosphorylation" RELATED UniMod-description [] synonym: "phosphorylationy" EXACT OMSSA-label [] synonym: "tyrosine phosphate" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 9 H 10 N 1 O 5 P 1" xref: MassAvg: "243.15" xref: MassMono: "243.029659" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00774 ! residues isobaric at 243.02-243.03 Da is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01455 ! O-phosphorylated residue [Term] id: MOD:00049 name: 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine def: "A protein modification that effectively converts an L-histidine residue to diphthamide." [ChEBI:16692, DeltaMass:122, PubMed:15316019, PubMed:7430147, RESID:AA0040, UniMod:375#H] synonym: "(2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium" EXACT RESID-systematic [] synonym: "(3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium" EXACT RESID-alternate [] synonym: "1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium" EXACT RESID-alternate [] synonym: "2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine" EXACT RESID-name [] synonym: "2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole" EXACT RESID-alternate [] synonym: "2-[3-carboxamido-3-(trimethylammonio)propyl]histidine" EXACT RESID-alternate [] synonym: "2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid" EXACT RESID-alternate [] synonym: "2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide" EXACT RESID-alternate [] synonym: "alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium" EXACT RESID-alternate [] synonym: "Diphth" EXACT PSI-MOD-label [] synonym: "Diphthamide" RELATED PSI-MS-label [] synonym: "Diphthamide" RELATED UniMod-description [] synonym: "diphthamide" EXACT RESID-alternate [] synonym: "diphthamide (from histidine)" EXACT DeltaMass-label [] synonym: "MOD_RES Diphthamide" EXACT UniProt-feature [] xref: DiffAvg: "143.21" xref: DiffFormula: "C 7 H 15 N 2 O 1" xref: DiffMono: "143.117890" xref: FormalCharge: "1+" xref: Formula: "C 13 H 22 N 5 O 2" xref: MassAvg: "280.35" xref: MassMono: "280.176801" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00050 name: N-acetyl-L-alanine def: "A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine." [PubMed:363452, PubMed:4700463, RESID:AA0041] subset: PSI-MOD-slim synonym: "(2S)-2-(acetamido)propanoic acid" EXACT RESID-systematic [] synonym: "2-(acetylamino)propanoic acid" EXACT RESID-alternate [] synonym: "2-(acetylazanyl)propanoic acid" EXACT RESID-alternate [] synonym: "AcAla" EXACT PSI-MOD-label [] synonym: "acetylalanine" EXACT RESID-alternate [] synonym: "MOD_RES N-acetylalanine" EXACT UniProt-feature [] synonym: "N-acetyl-L-alanine" EXACT RESID-name [] synonym: "N-acetylated L-alanine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 5 H 8 N 1 O 2" xref: MassAvg: "114.12" xref: MassMono: "114.055504" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00051 name: N-acetyl-L-aspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid." [ChEBI:21547, PubMed:1560020, PubMed:2395459, RESID:AA0042] subset: PSI-MOD-slim synonym: "(2S)-2-(acetamido)butanedioic acid" EXACT RESID-systematic [] synonym: "2-(acetylamino)butanedioic acid" EXACT RESID-alternate [] synonym: "2-(acetylazanyl)butanedioic acid" EXACT RESID-alternate [] synonym: "AcAsp" EXACT PSI-MOD-label [] synonym: "acetylaspartic acid" EXACT RESID-alternate [] synonym: "MOD_RES N-acetylaspartate" EXACT UniProt-feature [] synonym: "N-acetyl-L-aspartic acid" EXACT RESID-name [] synonym: "N-acetylated L-aspartic acid" EXACT PSI-MOD-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 6 H 8 N 1 O 4" xref: MassAvg: "158.13" xref: MassMono: "158.045333" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00052 name: N-acetyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine." [ChEBI:28939, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:1500421, PubMed:15350136, PubMed:6725286, RESID:AA0043] comment: incidental to RESID:AA0223 subset: PSI-MOD-slim synonym: "(2R)-2-acetamido-3-sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-3-mercaptopropanoic acid" EXACT RESID-alternate [] synonym: "2-acetylamino-3-sulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-3-sulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "MOD_RES N-acetylcysteine" EXACT UniProt-feature [] synonym: "N-acetyl-L-cysteine" EXACT RESID-name [] synonym: "N-acetylated cysteine" EXACT PSI-MOD-alternate [] synonym: "N-acetylcysteine" EXACT RESID-alternate [] synonym: "NAcCys" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0" xref: DiffMono: "42.010565" xref: Formula: "C 5 H 8 N 1 O 2 S 1" xref: MassAvg: "146.18" xref: MassMono: "146.027574" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00646 ! acetylated L-cysteine is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00053 name: N-acetyl-L-glutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid." [ChEBI:17533, PubMed:6725286, RESID:AA0044] subset: PSI-MOD-slim synonym: "(2S)-2-(acetamido)pentanedioic acid" EXACT RESID-systematic [] synonym: "2-(acetylamino)pentanedioic acid" EXACT RESID-alternate [] synonym: "2-(acetylazanyl)pentanedioic acid" EXACT RESID-alternate [] synonym: "acetylglutamic acid" EXACT RESID-alternate [] synonym: "AcGlu" EXACT PSI-MOD-label [] synonym: "MOD_RES N-acetylglutamate" EXACT UniProt-feature [] synonym: "N-acetyl-L-glutamic acid" EXACT RESID-name [] synonym: "N-acetylated L-glutamic acid" EXACT PSI-MOD-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 7 H 10 N 1 O 4" xref: MassAvg: "172.16" xref: MassMono: "172.060983" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00054 name: N-acetyl-L-glutamine def: "A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine." [RESID:AA0045] comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "(2S)-2-acetamido-5-pentanediamic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-5-amino-5-oxopentanoic acid" EXACT RESID-alternate [] synonym: "2-acetylamino-5-pentanediamic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-5-azanyl-5-oxopentanoic acid" EXACT RESID-alternate [] synonym: "acetylglutamine" EXACT RESID-alternate [] synonym: "AcGln" EXACT PSI-MOD-label [] synonym: "N-acetyl-L-glutamine" EXACT RESID-name [] synonym: "N-acetylated L-glutamine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 7 H 11 N 2 O 3" xref: MassAvg: "171.18" xref: MassMono: "171.076967" xref: Origin: "Q" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00055 name: N-acetylglycine def: "A protein modification that effectively converts a glycine residue to N-acetylglycine." [PubMed:272676, PubMed:5545094, PubMed:6754709, RESID:AA0046] subset: PSI-MOD-slim synonym: "(acetylamino)acetic acid" EXACT RESID-alternate [] synonym: "(acetylazanyl)ethanoic acid" EXACT RESID-alternate [] synonym: "2-(acetamido)ethanoic acid" EXACT RESID-systematic [] synonym: "2-(acetylamino)ethanoic acid" EXACT RESID-alternate [] synonym: "aceturic acid" EXACT RESID-alternate [] synonym: "AcGly" EXACT PSI-MOD-label [] synonym: "MOD_RES N-acetylglycine" EXACT UniProt-feature [] synonym: "N-acetylated glycine" EXACT PSI-MOD-alternate [] synonym: "N-acetylglycine" EXACT RESID-name [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 4 H 6 N 1 O 2" xref: MassAvg: "100.10" xref: MassMono: "100.039853" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00056 name: N-acetyl-L-isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine." [PubMed:8034631, RESID:AA0047] comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "(2S,3S)-2-acetamido-3-methylpentanoic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-3-methylpentanoic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-3-methylpentanoic acid" EXACT RESID-alternate [] synonym: "acetylisoleucine" EXACT RESID-alternate [] synonym: "AcIle" EXACT PSI-MOD-label [] synonym: "N-acetyl-L-isoleucine" EXACT RESID-name [] synonym: "N-acetylated L-isoleucine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 8 H 14 N 1 O 2" xref: MassAvg: "156.20" xref: MassMono: "156.102454" xref: Origin: "I" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00910 ! modified L-isoleucine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00057 name: N2-acetyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, RESID:AA0048] comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "(2S)-2-acetamido-6-aminohexanoic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-6-aminohexanoic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-6-azanylhexanoic acid" EXACT RESID-alternate [] synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "N2-acetyl-L-lysine" EXACT RESID-name [] synonym: "N2-acetylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "N2-acetyllysine" EXACT RESID-alternate [] synonym: "N2AcLys" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 8 H 15 N 2 O 2" xref: MassAvg: "171.22" xref: MassMono: "171.113353" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00723 ! N-acetylated L-lysine is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00058 name: N-acetyl-L-methionine def: "A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine." [PubMed:7944406, RESID:AA0049] subset: PSI-MOD-slim synonym: "(2S)-2-acetamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "2-acetylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "acetylmethionine" EXACT RESID-alternate [] synonym: "AcMet" EXACT PSI-MOD-label [] synonym: "methionamine" EXACT RESID-alternate [] synonym: "MOD_RES N-acetylmethionine" EXACT UniProt-feature [] synonym: "N-acetyl-L-methionine" EXACT RESID-name [] synonym: "N-acetylated L-methionine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0" xref: DiffMono: "42.010565" xref: Formula: "C 7 H 12 N 1 O 2 S 1" xref: MassAvg: "174.24" xref: MassMono: "174.058875" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00059 name: N-acetyl-L-proline def: "A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline." [PubMed:2928307, RESID:AA0050] subset: PSI-MOD-slim synonym: "(2S)-1-acetyl-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic [] synonym: "1-acetylproline" EXACT RESID-alternate [] synonym: "acetylproline" EXACT RESID-alternate [] synonym: "MOD_RES N-acetylproline" EXACT UniProt-feature [] synonym: "N-acetyl-L-proline" EXACT RESID-name [] synonym: "N-acetylated L-proline" EXACT PSI-MOD-alternate [] synonym: "N-acetylproline" EXACT RESID-alternate [] synonym: "NAcPro" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 7 H 10 N 1 O 2" xref: MassAvg: "140.16" xref: MassMono: "140.071154" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00060 name: N-acetyl-L-serine def: "A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:1880797, PubMed:2106685, PubMed:6997045, RESID:AA0051] subset: PSI-MOD-slim synonym: "(2S)-2-acetamido-3-hydroxypropanoic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-3-hydroxypropanoic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-3-hydroxypropanoic acid" EXACT RESID-alternate [] synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "MOD_RES N-acetylserine" EXACT UniProt-feature [] synonym: "N-acetyl-L-serine" EXACT RESID-name [] synonym: "N-acetylated L-serine" EXACT PSI-MOD-alternate [] synonym: "N-acetylserine" EXACT RESID-alternate [] synonym: "NAcSer" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 5 H 8 N 1 O 3" xref: MassAvg: "130.12" xref: MassMono: "130.050418" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00647 ! acetylated L-serine is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00061 name: N-acetyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:2106685, PubMed:6997045, RESID:AA0052] subset: PSI-MOD-slim synonym: "(2S,3R)-2-acetamido-3-hydroxybutanoic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-3-hydroxybutanoic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-3-hydroxybutanoic acid" EXACT RESID-alternate [] synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "Acetylation" RELATED UniMod-description [] synonym: "MOD_RES N-acetylthreonine" EXACT UniProt-feature [] synonym: "N-acetyl-L-threonine" EXACT RESID-name [] synonym: "N-acetylated L-threonine" EXACT PSI-MOD-alternate [] synonym: "N-acetylthreonine" EXACT RESID-alternate [] synonym: "N-methylcarbonylthreonine" EXACT RESID-alternate [] synonym: "NAcThr" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 6 H 10 N 1 O 3" xref: MassAvg: "144.15" xref: MassMono: "144.066068" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01186 ! acetylated L-threonine is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00062 name: N-acetyl-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:2506074, PubMed:475783, RESID:AA0053] synonym: "(2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate [] synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "AcTyr" EXACT PSI-MOD-label [] synonym: "MOD_RES N-acetyltyrosine" EXACT UniProt-feature [] synonym: "N-acetyl-L-tyrosine" EXACT RESID-name [] synonym: "N-acetylated L-tyrosine" EXACT PSI-MOD-alternate [] synonym: "N-acetyltyrosine" EXACT RESID-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 11 H 12 N 1 O 3" xref: MassAvg: "206.22" xref: MassMono: "206.081718" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00063 name: N-acetyl-L-valine def: "A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine." [PubMed:1735421, RESID:AA0054] subset: PSI-MOD-slim synonym: "(2S)-2-acetamido-3-methylbutanoic acid" EXACT RESID-systematic [] synonym: "2-acetylamino-3-methylbutanoic acid" EXACT RESID-alternate [] synonym: "2-acetylazanyl-3-methylbutanoic acid" EXACT RESID-alternate [] synonym: "AcVal" EXACT PSI-MOD-label [] synonym: "MOD_RES N-acetylvaline" EXACT UniProt-feature [] synonym: "N-acetyl-L-valine" EXACT RESID-name [] synonym: "N-acetylated L-valine" EXACT PSI-MOD-alternate [] synonym: "N-acetylvaline" EXACT RESID-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 7 H 12 N 1 O 2" xref: MassAvg: "142.18" xref: MassMono: "142.086804" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00920 ! modified L-valine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00064 name: N6-acetyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine." [ChEBI:17752, DeltaMass:214, OMSSA:24, PubMed:11369851, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:1680872, PubMed:670159, RESID:AA0055, UniMod:1#K] subset: PSI-MOD-slim synonym: "(2S)-6-acetamido-2-aminohexanoic acid" EXACT RESID-systematic [] synonym: "6-acetylamino-2-aminohexanoic acid" EXACT RESID-alternate [] synonym: "6-acetylazanyl-2-aminohexanoic acid" EXACT RESID-alternate [] synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "Acetylation" RELATED UniMod-description [] synonym: "acetylk" EXACT OMSSA-label [] synonym: "epsilon-acetyllysine" EXACT RESID-alternate [] synonym: "MOD_RES N6-acetyllysine" EXACT UniProt-feature [] synonym: "N(zeta)-acetyllysine" EXACT RESID-alternate [] synonym: "N6-acetyl-L-lysine" EXACT RESID-name [] synonym: "N6-acetylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "N6AcLys" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 8 H 14 N 2 O 2" xref: MassAvg: "170.21" xref: MassMono: "170.105528" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00723 ! N-acetylated L-lysine is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:00065 name: S-acetyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:1310545, PubMed:14730666, PubMed:15350136, RESID:AA0056, UniMod:1#C] subset: PSI-MOD-slim synonym: "(2R)-3-acetylsulfanyl-2-aminopropanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(acetylthio)propanoic acid" EXACT RESID-alternate [] synonym: "2-azanyl-3-(acetylsulfanyl)propanoic acid" EXACT RESID-alternate [] synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "Acetylation" RELATED UniMod-description [] synonym: "ACT_SITE S-acetylcysteine intermediate" EXACT UniProt-feature [] synonym: "cysteine acetate thioester" EXACT RESID-alternate [] synonym: "S-acetyl-L-cysteine" EXACT RESID-name [] synonym: "S-acetylcysteine" EXACT RESID-alternate [] synonym: "SAcCys" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0" xref: DiffMono: "42.010565" xref: Formula: "C 5 H 7 N 1 O 2 S 1" xref: MassAvg: "145.18" xref: MassMono: "145.019749" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00645 ! S-acetylated residue is_a: MOD:00646 ! acetylated L-cysteine [Term] id: MOD:00066 name: N-formylglycine def: "A protein modification that effectively converts a glycine residue to N-formylglycine." [PubMed:5139483, RESID:AA0057] synonym: "(formylamino)acetic acid" EXACT RESID-alternate [] synonym: "(formylamino)ethanoic acid" EXACT RESID-systematic [] synonym: "(formylazanyl)ethanoic acid" EXACT RESID-alternate [] synonym: "2-formamidoacetic acid" EXACT RESID-alternate [] synonym: "2-formamidoethanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N-formylglycine" EXACT UniProt-feature [] synonym: "N(alpha)-formylglycine" EXACT RESID-alternate [] synonym: "N-formylated glycine" EXACT PSI-MOD-alternate [] synonym: "N-formylglycine" EXACT RESID-name [] synonym: "NFoGly" EXACT PSI-MOD-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 3 H 4 N 1 O 2" xref: MassAvg: "86.07" xref: MassMono: "86.024203" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00409 ! N-formylated residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:00067 name: N-D-glucuronoylglycine def: "A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine." [OMSSA:50, PubMed:10858503, PubMed:12716131, PubMed:6493057, PubMed:7398618, RESID:AA0058] synonym: "2-(glucuronoylamino)ethanoic acid" EXACT RESID-systematic [] synonym: "Glucuronyl" RELATED PSI-MS-label [] synonym: "MOD_RES N-D-glucuronoyl glycine" EXACT UniProt-feature [] synonym: "N-D-glucuronoyl-glycine" EXACT RESID-name [] synonym: "N-D-glucuronyl-glycine" EXACT RESID-alternate [] synonym: "NGlcAGly" EXACT PSI-MOD-label [] synonym: "ntermpepglucuronylg" EXACT OMSSA-label [] xref: DiffAvg: "176.12" xref: DiffFormula: "C 6 H 8 N 0 O 6" xref: DiffMono: "176.032088" xref: Formula: "C 8 H 12 N 1 O 7" xref: MassAvg: "234.18" xref: MassMono: "234.061377" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00447 ! N-glucuronylated residue is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:00068 name: N-myristoylglycine def: "A protein modification that effectively converts a glycine residue to N-myristoylglycine." [OMSSA:80, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059, UniMod:45#G] subset: PSI-MOD-slim synonym: "(tetradecanoylamino)ethanoic acid" EXACT RESID-systematic [] synonym: "LIPID N-myristoyl glycine" EXACT UniProt-feature [] synonym: "Myristoyl" RELATED PSI-MS-label [] synonym: "Myristoylation" RELATED UniMod-description [] synonym: "N-(1-oxotetradecyl)glycine" EXACT RESID-alternate [] synonym: "N-(C14:0 aliphatic acyl)glycine" EXACT PSI-MOD-alternate [] synonym: "N-myristoyl-glycine" EXACT RESID-name [] synonym: "N-myristoylated glycine" EXACT PSI-MOD-alternate [] synonym: "N-myristylglycine" EXACT RESID-alternate [] synonym: "N-tetradecanoylglycine" EXACT RESID-alternate [] synonym: "NMyrGly" EXACT PSI-MOD-label [] synonym: "ntermpepmyristoylationg" EXACT OMSSA-label [] xref: DiffAvg: "210.36" xref: DiffFormula: "C 14 H 26 N 0 O 1" xref: DiffMono: "210.198365" xref: Formula: "C 16 H 30 N 1 O 2" xref: MassAvg: "268.42" xref: MassMono: "268.227654" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00650 ! N-myristoylated residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:00069 name: N-palmitoyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, PubMed:9593755, RESID:AA0060] comment: incidental to RESID:AA0107 incidental to RESID:AA0309 subset: PSI-MOD-slim synonym: "(2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-hexadecanamido-3-sulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "2-hexadecanoylamino-3-mercaptopropanoic acid" EXACT RESID-alternate [] synonym: "LIPID N-palmitoyl cysteine" EXACT UniProt-feature [] synonym: "N-(1-oxahexadecyl)-L-cysteine" EXACT RESID-alternate [] synonym: "N-palmitoyl-L-cysteine" EXACT RESID-name [] synonym: "N-palmitoylated L-cysteine" EXACT PSI-MOD-alternate [] synonym: "NPamCys" EXACT PSI-MOD-label [] synonym: "Palmitoyl" RELATED PSI-MS-label [] synonym: "Palmitoylation" RELATED UniMod-description [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" xref: DiffMono: "238.229666" xref: Formula: "C 19 H 36 N 1 O 2 S 1" xref: MassAvg: "342.56" xref: MassMono: "342.246675" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01684 ! palmitoylated-L-cysteine is_a: MOD:01685 ! alpha-amino palmitoylated residue [Term] id: MOD:00070 name: N-methyl-L-alanine def: "A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine." [ChEBI:17519, PubMed:323502, PubMed:337304, PubMed:7007074, RESID:AA0061] comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. subset: PSI-MOD-slim synonym: "(2S)-2-methylaminopropanoic acid" EXACT RESID-systematic [] synonym: "2-methylazanylpropanoic acid" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES N-methylalanine" EXACT UniProt-feature [] synonym: "N-methyl-L-alanine" EXACT RESID-name [] synonym: "N-methylalanine" EXACT RESID-alternate [] synonym: "N-methylated L-alanine" EXACT PSI-MOD-alternate [] synonym: "NMe1Ala" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 4 H 7 N 1 O 1" xref: MassAvg: "85.11" xref: MassMono: "85.052764" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01461 ! N-methylated alanine is_a: MOD:01680 ! alpha-amino monomethylated residue [Term] id: MOD:00071 name: N,N,N-trimethyl-L-alanine def: "A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine." [PubMed:12590383, PubMed:332162, PubMed:3979397, PubMed:6778808, PubMed:7715456, RESID:AA0062] subset: PSI-MOD-slim synonym: "(1S)-1-carboxy-N,N,N-trimethylethanaminium" EXACT RESID-systematic [] synonym: "(1S)-1-carboxy-N,N,N-trimethylethanazanium" EXACT RESID-alternate [] synonym: "(2S)-2-(trimethylammonio)propanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N,N,N-trimethylalanine" EXACT UniProt-feature [] synonym: "N,N,N-trimethyl-L-alanine" EXACT RESID-name [] synonym: "N,N,N-trimethylalanine cation" EXACT RESID-alternate [] synonym: "N,N,N-trimethylalaninium" EXACT RESID-alternate [] synonym: "N,N,N-trimethylated L-alanine" EXACT PSI-MOD-alternate [] synonym: "N2Me3+Ala" EXACT PSI-MOD-label [] synonym: "NMe3Ala" EXACT PSI-MOD-label [] synonym: "tri-Methylation" RELATED UniMod-description [] synonym: "Trimethyl" RELATED PSI-MS-label [] xref: DiffAvg: "43.09" xref: DiffFormula: "C 3 H 7 N 0 O 0" xref: DiffMono: "43.054227" xref: FormalCharge: "1+" xref: Formula: "C 6 H 13 N 1 O 1" xref: MassAvg: "115.18" xref: MassMono: "115.099165" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01461 ! N-methylated alanine is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue [Term] id: MOD:00072 name: N-methylglycine def: "A protein modification that effectively converts a glycine residue to N-methylglycine." [ChEBI:15611, DeltaMass:0, PubMed:1593629, RESID:AA0063] comment: DeltaMass also has an entry for the free amino acid. Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. synonym: "L-sarcosine" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "methylaminoacetic acid" EXACT RESID-alternate [] synonym: "methylaminoethanoic acid" EXACT RESID-systematic [] synonym: "Methylation" RELATED UniMod-description [] synonym: "N-methylated glycine" EXACT PSI-MOD-alternate [] synonym: "N-methylglycine" EXACT RESID-name [] synonym: "NMe1Gly" EXACT PSI-MOD-label [] synonym: "Sar" EXACT DeltaMass-label [] synonym: "Sarcosine" EXACT DeltaMass-label [] synonym: "Sarcosyl" EXACT DeltaMass-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 3 H 5 N 1 O 1" xref: MassAvg: "71.08" xref: MassMono: "71.037114" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00570 ! residues isobaric at 71.037114 Da is_a: MOD:00714 ! methylated glycine is_a: MOD:01680 ! alpha-amino monomethylated residue [Term] id: MOD:00073 name: N-methyl-L-methionine def: "A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine." [DeltaMass:169, PubMed:323502, PubMed:3298225, RESID:AA0064] comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. subset: PSI-MOD-slim synonym: "(2S)-2-methylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-methylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methyl Methionyl" EXACT DeltaMass-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES N-methylmethionine" EXACT UniProt-feature [] synonym: "N-methyl-L-methionine" EXACT RESID-name [] synonym: "N-methylated L-methionine" EXACT PSI-MOD-alternate [] synonym: "N-methylmethionine" EXACT RESID-alternate [] synonym: "NMe1Met" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0" xref: DiffMono: "14.015650" xref: Formula: "C 6 H 11 N 1 O 1 S 1" xref: MassAvg: "145.22" xref: MassMono: "145.056135" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01463 ! N-methylated methionine is_a: MOD:01680 ! alpha-amino monomethylated residue [Term] id: MOD:00074 name: N-methyl-L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine." [PubMed:2577730, PubMed:413571, RESID:AA0065] comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. subset: PSI-MOD-slim synonym: "(2S)-2-methylamino-3-phenylpropanoic acid" EXACT RESID-systematic [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES N-methylphenylalanine" EXACT UniProt-feature [] synonym: "N-methyl-L-phenylalanine" EXACT RESID-name [] synonym: "N-methylated L-phenylalanine" EXACT PSI-MOD-alternate [] synonym: "N-methylphenylalanine" EXACT RESID-alternate [] synonym: "NMe1Phe" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 10 H 11 N 1 O 1" xref: MassAvg: "161.20" xref: MassMono: "161.084064" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01063 ! monomethylated phenylalanine is_a: MOD:01680 ! alpha-amino monomethylated residue [Term] id: MOD:00075 name: N,N-dimethyl-L-proline def: "A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline." [ChEBI:21451, PubMed:12964758, PubMed:14570711, PubMed:193025, PubMed:3882426, PubMed:6254758, RESID:AA0066, UniMod:529] comment: UniMod terminal specification corrected [JSG]. subset: PSI-MOD-slim synonym: "(2S)-2-carboxy-1,1-dimethylpyrrolidinium" EXACT RESID-systematic [] synonym: "1,1-dimethyl-L-prolinium" EXACT RESID-alternate [] synonym: "Delta:H(5)C(2)" RELATED UniMod-interim [] synonym: "Dimethyl" RELATED PSI-MS-label [] synonym: "Dimethylation of proline residue" RELATED UniMod-description [] synonym: "MOD_RES N,N-dimethylproline" EXACT UniProt-feature [] synonym: "N,N-dimethyl-L-proline" EXACT RESID-name [] synonym: "N,N-dimethyl-L-prolinium" EXACT RESID-alternate [] synonym: "N,N-dimethylated L-proline" EXACT PSI-MOD-alternate [] synonym: "NMe2Pro" EXACT PSI-MOD-label [] synonym: "stachydrin" EXACT RESID-alternate [] xref: DiffAvg: "29.06" xref: DiffFormula: "C 2 H 5 N 0 O 0" xref: DiffMono: "29.038577" xref: FormalCharge: "1+" xref: Formula: "C 7 H 13 N 1 O 1" xref: MassAvg: "127.19" xref: MassMono: "127.099165" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00710 ! protonated-dimethylated residue is_a: MOD:01462 ! N-methylated proline [Term] id: MOD:00076 name: symmetric dimethyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine." [PubMed:12964758, PubMed:14570711, PubMed:15835918, PubMed:2426402, PubMed:5128665, RESID:AA0067, UniMod:36#R] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid" EXACT RESID-systematic [] synonym: "di-Methylation" RELATED UniMod-description [] synonym: "Dimethyl" RELATED PSI-MS-label [] synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature [] synonym: "MOD_RES Symmetric dimethylarginine" EXACT UniProt-feature [] synonym: "N3,N4-dimethylarginine" EXACT RESID-alternate [] synonym: "N5-[(methylamino)(methylimino)methyl]ornithine" EXACT RESID-alternate [] synonym: "NG,N'G-dimethylarginine" EXACT RESID-alternate [] synonym: "NoNo'Me2Arg" EXACT PSI-MOD-label [] synonym: "omega-N,omega-N'-dimethyl-L-arginine" EXACT RESID-name [] synonym: "omega-N,omega-N'-dimethylated L-arginine" EXACT PSI-MOD-alternate [] synonym: "symmetric dimethylarginine" EXACT RESID-alternate [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 16 N 4 O 1" xref: MassAvg: "184.24" xref: MassMono: "184.132411" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00602 ! N-methylated residue is_a: MOD:00783 ! dimethylated L-arginine [Term] id: MOD:00077 name: asymmetric dimethyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine." [ChEBI:17929, PubMed:11152131, PubMed:12964758, PubMed:14570711, PubMed:15835918, PubMed:3032834, RESID:AA0068, UniMod:36#R] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid" EXACT RESID-systematic [] synonym: "asymmetric dimethylarginine" EXACT RESID-alternate [] synonym: "di-Methylation" RELATED UniMod-description [] synonym: "Dimethyl" RELATED PSI-MS-label [] synonym: "MOD_RES Asymmetric dimethylarginine" EXACT UniProt-feature [] synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature [] synonym: "N5-[(dimethylamino)(imino)methyl]ornithine" EXACT RESID-alternate [] synonym: "NG,NG-dimethylarginine" EXACT RESID-alternate [] synonym: "NoNoMe2Arg" EXACT PSI-MOD-label [] synonym: "omega-N,omega-N-dimethlyated L-arginine" EXACT PSI-MOD-alternate [] synonym: "omega-N,omega-N-dimethyl-L-arginine" EXACT RESID-name [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 16 N 4 O 1" xref: MassAvg: "184.24" xref: MassMono: "184.132411" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00602 ! N-methylated residue is_a: MOD:00783 ! dimethylated L-arginine [Term] id: MOD:00078 name: omega-N-methyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine." [PubMed:11875433, PubMed:15835918, PubMed:2426402, PubMed:5128665, RESID:AA0069] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid" EXACT RESID-systematic [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES Omega-N-methylarginine" EXACT UniProt-feature [] synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature [] synonym: "NG-methylarginine" EXACT RESID-alternate [] synonym: "NoMeArg" EXACT PSI-MOD-label [] synonym: "omega-N-methyl-L-arginine" EXACT RESID-name [] synonym: "omega-N-methylated L-arginine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 14 N 4 O 1" xref: MassAvg: "170.22" xref: MassMono: "170.116761" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00414 ! monomethylated L-arginine is_a: MOD:00602 ! N-methylated residue [Term] id: MOD:00079 name: N4-methyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine." [OMSSA:75, PubMed:11875433, PubMed:2356973, PubMed:3782095, RESID:AA0070, UniMod:34#N] subset: PSI-MOD-slim synonym: "(2S)-2-amino-N4-methylbutanediamic acid" EXACT RESID-systematic [] synonym: "beta-aspartyl methylamide" EXACT RESID-alternate [] synonym: "beta-methylasparagine" RELATED RESID-misnomer [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "methyln" EXACT OMSSA-label [] synonym: "MOD_RES N4-methylasparagine" EXACT UniProt-feature [] synonym: "N(gamma)-methylasparagine" EXACT RESID-alternate [] synonym: "N-methylasparagine" EXACT RESID-alternate [] synonym: "N4-methyl-L-asparagine" EXACT RESID-name [] synonym: "N4-methylated L-asparagine" EXACT PSI-MOD-alternate [] synonym: "N4Me1Asn" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 5 H 8 N 2 O 2" xref: MassAvg: "128.13" xref: MassMono: "128.058578" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00602 ! N-methylated residue is_a: MOD:00673 ! methylated asparagine is_a: MOD:00894 ! residues isobaric at 128.058578 Da [Term] id: MOD:00080 name: N5-methyl-L-glutamine def: "A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine." [ChEBI:17592, DeltaMass:166, PubMed:11118225, PubMed:11875433, PubMed:365579, RESID:AA0071] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-methylamino-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "2-amino-N5-methylpentanediamic acid" EXACT RESID-alternate [] synonym: "gamma-methylglutamine" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES N5-methylglutamine" EXACT UniProt-feature [] synonym: "N(delta)-methylglutamine" EXACT RESID-alternate [] synonym: "N-methylglutamine" EXACT RESID-alternate [] synonym: "N5-methyl-L-glutamine" EXACT RESID-name [] synonym: "N5-methylated L-glutamine" EXACT PSI-MOD-alternate [] synonym: "N5Me1Gln" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 6 H 10 N 2 O 2" xref: MassAvg: "142.16" xref: MassMono: "142.074228" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00602 ! N-methylated residue is_a: MOD:00722 ! monomethylated L-glutamine [Term] id: MOD:00081 name: L-glutamic acid 5-methyl ester (Glu) def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester." [DeltaMass:167, OMSSA:17, OMSSA:70, PubMed:16888, PubMed:6300110, RESID:AA0072#GLU, UniMod:34#E] comment: DeltaMass gives the formula "C 6 H 9 O 1 N 3" with mass 143 (formula incorrect, N and O reversed) [JSG]. subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate [] synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate [] synonym: "5-methyl esterified L-glutamic acid" EXACT PSI-MOD-alternate [] synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate [] synonym: "5-methyl L-glutamate" EXACT RESID-alternate [] synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate [] synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate [] synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name [] synonym: "meestere" EXACT OMSSA-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "methyl ester" RELATED UniMod-alternate [] synonym: "Methylation" RELATED UniMod-description [] synonym: "methyle" EXACT OMSSA-label [] synonym: "MOD_RES Glutamate methyl ester (Glu)" EXACT UniProt-feature [] synonym: "O-methyl Glutamyl" EXACT DeltaMass-label [] synonym: "O5MeGlu" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 6 H 9 N 1 O 3" xref: MassAvg: "143.14" xref: MassMono: "143.058243" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01453 ! L-glutamic acid 5-methyl ester [Term] id: MOD:00082 name: 3'-methyl-L-histidine def: "A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine)." [PubMed:10660523, PubMed:11875433, PubMed:3467365, PubMed:6692818, PubMed:8076, PubMed:8645219, RESID:AA0073] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "1-methylhistidine" RELATED RESID-misnomer [] synonym: "3'-methyl-L-histidine" EXACT RESID-name [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES Pros-methylhistidine" EXACT UniProt-feature [] synonym: "N(delta)-methylhistidine" EXACT RESID-alternate [] synonym: "N(pi)-methylhistidine" EXACT RESID-alternate [] synonym: "NpMeHis" EXACT PSI-MOD-label [] synonym: "pros-methylated L-histidine" EXACT PSI-MOD-alternate [] synonym: "pros-methylhistidine" EXACT RESID-alternate [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 9 N 3 O 1" xref: MassAvg: "151.17" xref: MassMono: "151.074562" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00724 ! N-methylated L-histidine [Term] id: MOD:00083 name: N6,N6,N6-trimethyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine." [ChEBI:17311, PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, RESID:AA0074] comment: DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine; for trimethylated lysine starting from protonated lysine see MOD:00855 subset: PSI-MOD-slim synonym: "(5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium" EXACT RESID-systematic [] synonym: "2-amino-6-(trimethylammonio)hexanoic acid" EXACT RESID-alternate [] synonym: "5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium" EXACT RESID-alternate [] synonym: "epsilon-trimethyllysine" EXACT RESID-alternate [] synonym: "MOD_RES N6,N6,N6-trimethyllysine" EXACT UniProt-feature [] synonym: "N(zeta)-trimethyllysine" EXACT RESID-alternate [] synonym: "N-trimethylation (of lysine)" EXACT DeltaMass-label [] synonym: "N6,N6,N6-trimethyl-L-lysine" EXACT RESID-name [] synonym: "N6,N6,N6-trimethylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "N6,N6,N6-trimethyllysin-N6-ium" EXACT RESID-alternate [] synonym: "N6,N6,N6-trimethyllysine cation" EXACT RESID-alternate [] synonym: "N6Me3+Lys" EXACT PSI-MOD-label [] synonym: "tri-Methylation" RELATED UniMod-description [] synonym: "Trimethyl" RELATED PSI-MS-label [] xref: DiffAvg: "43.09" xref: DiffFormula: "C 3 H 7 N 0 O 0" xref: DiffMono: "43.054227" xref: FormalCharge: "1+" xref: Formula: "C 9 H 19 N 2 O 1" xref: MassAvg: "171.26" xref: MassMono: "171.149190" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00602 ! N-methylated residue is_a: MOD:00663 ! methylated lysine is_a: MOD:00711 ! trimethylated protonated-residue [Term] id: MOD:00084 name: N6,N6-dimethyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine." [OMSSA:36, PubMed:10550045, PubMed:12964758, PubMed:14570711, PubMed:3100523, PubMed:8453381, RESID:AA0075, UniMod:36#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(dimethylamino)hexanoic acid" EXACT RESID-systematic [] synonym: "di-Methylation" RELATED UniMod-description [] synonym: "Dimethyl" RELATED PSI-MS-label [] synonym: "dimethylk" EXACT OMSSA-label [] synonym: "epsilon-dimethyllysine" EXACT RESID-alternate [] synonym: "lysine derivative Lys(y)" EXACT RESID-alternate [] synonym: "MOD_RES N6,N6-dimethyllysine" EXACT UniProt-feature [] synonym: "N(zeta)-dimethyllysine" EXACT RESID-alternate [] synonym: "N6,N6-dimethyl-L-lysine" EXACT RESID-name [] synonym: "N6,N6-dimethylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "N6Me2Lys" EXACT PSI-MOD-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 16 N 2 O 1" xref: MassAvg: "156.23" xref: MassMono: "156.126263" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00429 ! dimethylated residue is_a: MOD:00602 ! N-methylated residue is_a: MOD:00663 ! methylated lysine [Term] id: MOD:00085 name: N6-methyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine." [ChEBI:17604, DeltaMass:165, PubMed:11875433, PubMed:3926756, RESID:AA0076, UniMod:34#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-methylaminohexanoic acid" EXACT RESID-systematic [] synonym: "epsilon-methyllysine" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES N6-methyllysine" EXACT UniProt-feature [] synonym: "N(zeta)-methyllysine" EXACT RESID-alternate [] synonym: "N-methyl Lysyl" EXACT DeltaMass-label [] synonym: "N6-methyl-L-lysine" EXACT RESID-name [] synonym: "N6-methylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "N6Me1Lys" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 14 N 2 O 1" xref: MassAvg: "142.20" xref: MassMono: "142.110613" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00602 ! N-methylated residue is_a: MOD:01683 ! monomethylated L-lysine [Term] id: MOD:00086 name: N6-palmitoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine." [OMSSA:93, PubMed:2498336, PubMed:7801126, PubMed:7939682, RESID:AA0077, UniMod:47#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(hexadecanoylamino)hexanoic acid" EXACT RESID-systematic [] synonym: "2-amino-6-(hexadecanamido)hexanoic acid" EXACT RESID-alternate [] synonym: "epsilon-palmitoyllysine" EXACT RESID-alternate [] synonym: "LIPID N6-palmitoyl lysine" EXACT UniProt-feature [] synonym: "N(zeta)-palmitoyllysine" EXACT RESID-alternate [] synonym: "N6-(1-oxohexadecyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-palmitoyl-L-lysine" EXACT RESID-name [] synonym: "N6-palmitoylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "N6PamLys" EXACT PSI-MOD-label [] synonym: "Palmitoyl" RELATED PSI-MS-label [] synonym: "Palmitoylation" RELATED UniMod-description [] synonym: "palmitoylationk" EXACT OMSSA-label [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1" xref: DiffMono: "238.229666" xref: Formula: "C 22 H 42 N 2 O 2" xref: MassAvg: "366.59" xref: MassMono: "366.324629" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00651 ! N-palmitoylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:00087 name: N6-myristoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine." [OMSSA:81, PubMed:1402651, PubMed:8346241, RESID:AA0078, UniMod:45#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(tetradecanoylamino)hexanoic acid" EXACT RESID-systematic [] synonym: "2-amino-6-(tetradecanamido)hexanoic acid" EXACT RESID-alternate [] synonym: "epsilon-myristoyllysine" EXACT RESID-alternate [] synonym: "LIPID N6-myristoyl lysine" EXACT UniProt-feature [] synonym: "Myristoyl" RELATED PSI-MS-label [] synonym: "Myristoylation" RELATED UniMod-description [] synonym: "myristoylationk" EXACT OMSSA-label [] synonym: "N(zeta)-myristoyllysine" EXACT RESID-alternate [] synonym: "N6-(1-oxotetradecyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-(C14:0 aliphatic acyl)lysine" EXACT PSI-MOD-alternate [] synonym: "N6-myristoyl-L-lysine" EXACT RESID-name [] synonym: "N6-myristoylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "N6MyrLys" EXACT PSI-MOD-label [] xref: DiffAvg: "210.36" xref: DiffFormula: "C 14 H 26 N 0 O 1" xref: DiffMono: "210.198365" xref: Formula: "C 20 H 38 N 2 O 2" xref: MassAvg: "338.54" xref: MassMono: "338.293328" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00650 ! N-myristoylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:00088 name: O-palmitoyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine." [OMSSA:95, PubMed:6642431, PubMed:8413602, RESID:AA0079, UniMod:47#T] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid" EXACT RESID-systematic [] synonym: "L-threonine hexadecanoate ester" EXACT RESID-alternate [] synonym: "LIPID O-palmitoyl threonine" EXACT UniProt-feature [] synonym: "O-palmitoyl-L-threonine" EXACT RESID-name [] synonym: "O-palmitoylated L-threonine" EXACT PSI-MOD-alternate [] synonym: "O3-palmitoyl-threonine" EXACT RESID-alternate [] synonym: "OPamThr" EXACT PSI-MOD-label [] synonym: "Palmitoyl" RELATED PSI-MS-label [] synonym: "Palmitoylation" RELATED UniMod-description [] synonym: "palmitoylationt" EXACT OMSSA-label [] synonym: "threonine palmitate ester" EXACT RESID-alternate [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1" xref: DiffMono: "238.229666" xref: Formula: "C 20 H 37 N 1 O 3" xref: MassAvg: "339.52" xref: MassMono: "339.277344" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00652 ! O-palmitoylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00089 name: O-palmitoyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine." [OMSSA:94, PubMed:3467339, RESID:AA0080, UniMod:47#S] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(hexadecanoyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "ACT_SITE O-palmitoyl serine intermediate" EXACT UniProt-feature [] synonym: "L-serine hexadecanoate ester" EXACT RESID-alternate [] synonym: "LIPID O-palmitoyl serine" EXACT UniProt-feature [] synonym: "O-palmitoyl-L-serine" EXACT RESID-name [] synonym: "O-palmitoylated L-serine" EXACT PSI-MOD-alternate [] synonym: "O3-palmitoyl-serine" EXACT RESID-alternate [] synonym: "OPamSer" EXACT PSI-MOD-label [] synonym: "Palmitoyl" RELATED PSI-MS-label [] synonym: "Palmitoylation" RELATED UniMod-description [] synonym: "palmitoylations" EXACT OMSSA-label [] synonym: "serine palmitate ester" EXACT RESID-alternate [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1" xref: DiffMono: "238.229666" xref: Formula: "C 19 H 35 N 1 O 3" xref: MassAvg: "325.49" xref: MassMono: "325.261694" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00652 ! O-palmitoylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00090 name: L-alanine amide def: "A protein modification that effectively converts an L-alanine residue to L-alanine amide." [PubMed:1377792, PubMed:2069951, PubMed:8472537, PubMed:952951, RESID:AA0081] subset: PSI-MOD-slim synonym: "(2S)-2-aminopropanamide" EXACT RESID-systematic [] synonym: "AlaN" EXACT PSI-MOD-label [] synonym: "alaninamide" EXACT RESID-alternate [] synonym: "amidated L-alanine" EXACT PSI-MOD-alternate [] synonym: "L-alanine amide" EXACT RESID-name [] synonym: "MOD_RES Alanine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 3 H 7 N 2 O 1" xref: MassAvg: "87.10" xref: MassMono: "87.055838" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00901 ! modified L-alanine residue [Term] id: MOD:00091 name: L-arginine amide def: "A protein modification that effectively converts an L-arginine residue to L-arginine amide." [PubMed:2229025, PubMed:2753890, PubMed:743209, RESID:AA0082] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide" EXACT RESID-systematic [] synonym: "2-amino-5-carbamimidamidopentanamide" EXACT RESID-alternate [] synonym: "2-amino-5-guanidinopentanamide" EXACT RESID-alternate [] synonym: "amidated L-arginine" EXACT PSI-MOD-alternate [] synonym: "argininamide" EXACT RESID-alternate [] synonym: "ArgN" EXACT PSI-MOD-label [] synonym: "L-arginine amide" EXACT RESID-name [] synonym: "MOD_RES Arginine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 6 H 14 N 5 O 1" xref: MassAvg: "172.21" xref: MassMono: "172.119835" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00092 name: L-asparagine amide def: "A protein modification that effectively converts an L-asparagine residue to L-asparagine amide." [PubMed:2753132, PubMed:279902, PubMed:3415690, RESID:AA0083] subset: PSI-MOD-slim synonym: "(2S)-2-aminobutanediamide" EXACT RESID-systematic [] synonym: "amidated L-asparagine" EXACT PSI-MOD-alternate [] synonym: "AsnN" EXACT PSI-MOD-label [] synonym: "asparaginamide" EXACT RESID-alternate [] synonym: "L-asparagine amide" EXACT RESID-name [] synonym: "MOD_RES Asparagine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 4 H 8 N 3 O 2" xref: MassAvg: "130.13" xref: MassMono: "130.061652" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00093 name: L-aspartic acid 1-amide def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide." [PubMed:2542051, RESID:AA0084] subset: PSI-MOD-slim synonym: "(2S)-2-amino-1-butanediamic acid" EXACT RESID-systematic [] synonym: "1-amidated L-aspartic acid" EXACT PSI-MOD-alternate [] synonym: "3,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate [] synonym: "3-amino-succinamic acid" EXACT RESID-alternate [] synonym: "alpha-asparagine" EXACT RESID-alternate [] synonym: "AspN" EXACT PSI-MOD-label [] synonym: "isoasparagine" EXACT RESID-alternate [] synonym: "L-aspartic acid 1-amide" EXACT RESID-name [] synonym: "MOD_RES Aspartic acid 1-amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 4 H 7 N 2 O 3" xref: MassAvg: "131.11" xref: MassMono: "131.045667" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:00094 name: L-cysteine amide def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine amide." [PubMed:1892838, PubMed:7149738, RESID:AA0085] subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-sulfanylpropanamide" EXACT RESID-systematic [] synonym: "2-amino-3-mercaptopropanamide" EXACT RESID-alternate [] synonym: "amidated L-cysteine" EXACT PSI-MOD-alternate [] synonym: "CysN" EXACT PSI-MOD-label [] synonym: "cysteinamide" EXACT RESID-alternate [] synonym: "L-cysteine amide" EXACT RESID-name [] synonym: "MOD_RES Cysteine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1 S 0" xref: DiffMono: "-0.984016" xref: Formula: "C 3 H 7 N 2 O 1 S 1" xref: MassAvg: "119.16" xref: MassMono: "119.027909" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00095 name: L-glutamine amide def: "A protein modification that effectively converts an L-glutamine residue to L-glutamine amide." [PubMed:7673220, PubMed:9048550, RESID:AA0086] subset: PSI-MOD-slim synonym: "(2S)-2-aminopentanediamide" EXACT RESID-systematic [] synonym: "amidated L-glutamine" EXACT PSI-MOD-alternate [] synonym: "GlnN" EXACT PSI-MOD-label [] synonym: "glutaminamide" EXACT RESID-alternate [] synonym: "L-glutamine amide" EXACT RESID-name [] synonym: "MOD_RES Glutamine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 5 H 10 N 3 O 2" xref: MassAvg: "144.15" xref: MassMono: "144.077302" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00907 ! modified L-glutamine residue [Term] id: MOD:00096 name: L-glutamic acid 1-amide def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide." [PubMed:1093875, PubMed:14550575, RESID:AA0087] subset: PSI-MOD-slim synonym: "(2S)-2-amino-1-pentanediamic acid" EXACT RESID-systematic [] synonym: "1-amidated L-glutamic acid" EXACT PSI-MOD-alternate [] synonym: "4,5-diamino-5-oxopentanoic acid" EXACT RESID-alternate [] synonym: "GluN" EXACT PSI-MOD-label [] synonym: "isoglutamine" EXACT RESID-alternate [] synonym: "L-glutamic acid 1-amide" EXACT RESID-name [] synonym: "MOD_RES Glutamic acid 1-amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 5 H 9 N 2 O 3" xref: MassAvg: "145.14" xref: MassMono: "145.061317" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00097 name: glycine amide def: "A protein modification that effectively converts a glycine residue to glycine amide." [PubMed:13591312, RESID:AA0088] subset: PSI-MOD-slim synonym: "2-aminoacetamide" EXACT RESID-alternate [] synonym: "2-aminoethanamide" EXACT RESID-systematic [] synonym: "2-azanylethanamide" EXACT RESID-alternate [] synonym: "amidated glycine" EXACT PSI-MOD-alternate [] synonym: "glycinamide" EXACT RESID-alternate [] synonym: "glycine amide" EXACT RESID-name [] synonym: "GlyN" EXACT PSI-MOD-label [] synonym: "MOD_RES Glycine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 2 H 5 N 2 O 1" xref: MassAvg: "73.07" xref: MassMono: "73.040188" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:00098 name: L-histidine amide def: "A protein modification that effectively converts an L-histidine residue to L-histidine amide." [PubMed:2153586, PubMed:2307683, PubMed:2839478, RESID:AA0089] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(1H-imidazol-4-yl)propanamide" EXACT RESID-systematic [] synonym: "amidated L-histidine" EXACT PSI-MOD-alternate [] synonym: "HisN" EXACT PSI-MOD-label [] synonym: "histidinamide" EXACT RESID-alternate [] synonym: "L-histidine amide" EXACT RESID-name [] synonym: "MOD_RES Histidine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 6 H 9 N 4 O 1" xref: MassAvg: "153.16" xref: MassMono: "153.077636" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00099 name: L-isoleucine amide def: "A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide." [RESID:AA0090] subset: PSI-MOD-slim synonym: "(2S,3S)-2-amino-3-methylpentanamide" EXACT RESID-systematic [] synonym: "amidated L-isoleucine" EXACT PSI-MOD-alternate [] synonym: "IleN" EXACT PSI-MOD-label [] synonym: "isoleucinamide" EXACT RESID-alternate [] synonym: "L-isoleucine amide" EXACT RESID-name [] synonym: "MOD_RES Isoleucine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 6 H 13 N 2 O 1" xref: MassAvg: "129.18" xref: MassMono: "129.102788" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00910 ! modified L-isoleucine residue [Term] id: MOD:00100 name: L-leucine amide def: "A protein modification that effectively converts an L-leucine residue to L-leucine amide." [PubMed:2578459, RESID:AA0091] subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-methylpentanamide" EXACT RESID-systematic [] synonym: "2-amino-4-methylvaleramide" EXACT RESID-alternate [] synonym: "2-azanyl-4-methylpentanamide" EXACT RESID-alternate [] synonym: "alpha-aminoisocaproamide" EXACT RESID-alternate [] synonym: "amidated L-leucine" EXACT PSI-MOD-alternate [] synonym: "L-leucine amide" EXACT RESID-name [] synonym: "leucinamide" EXACT RESID-alternate [] synonym: "LeuN" EXACT PSI-MOD-label [] synonym: "MOD_RES Leucine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 6 H 13 N 2 O 1" xref: MassAvg: "129.18" xref: MassMono: "129.102788" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00911 ! modified L-leucine residue [Term] id: MOD:00101 name: L-lysine amide def: "A protein modification that effectively converts an L-lysine residue to L-lysine amide." [PubMed:6579533, RESID:AA0092] subset: PSI-MOD-slim synonym: "(2S)-2,6-diaminohexanamide" EXACT RESID-systematic [] synonym: "amidated L-lysine" EXACT PSI-MOD-alternate [] synonym: "L-lysine amide" EXACT RESID-name [] synonym: "lysinamide" EXACT RESID-alternate [] synonym: "LysN" EXACT PSI-MOD-label [] synonym: "MOD_RES Lysine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 6 H 14 N 3 O 1" xref: MassAvg: "144.20" xref: MassMono: "144.113687" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00102 name: L-methionine amide def: "A protein modification that effectively converts an L-methionine residue to L-methionine amide." [PubMed:4375977, RESID:AA0093] subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-(methylsulfanyl)butanamide" EXACT RESID-systematic [] synonym: "2-amino-4-(methylthio)butanamide" EXACT RESID-alternate [] synonym: "amidated L-methionine" EXACT PSI-MOD-alternate [] synonym: "L-methionine amide" EXACT RESID-name [] synonym: "methioninamide" EXACT RESID-alternate [] synonym: "MetN" EXACT PSI-MOD-label [] synonym: "MOD_RES Methionine amide" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1 S 0" xref: DiffMono: "-0.984016" xref: Formula: "C 5 H 11 N 2 O 1 S 1" xref: MassAvg: "147.22" xref: MassMono: "147.059209" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00103 name: L-phenylalanine amide def: "A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide." [PubMed:2905621, PubMed:8868490, RESID:AA0094] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-phenylpropanamide" EXACT RESID-systematic [] synonym: "amidated L-phenylalanine" EXACT PSI-MOD-alternate [] synonym: "L-phenylalanine amide" EXACT RESID-name [] synonym: "MOD_RES Phenylalanine amide" EXACT UniProt-feature [] synonym: "PheN" EXACT PSI-MOD-label [] synonym: "phenylalaninamide" EXACT RESID-alternate [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 9 H 11 N 2 O 1" xref: MassAvg: "163.20" xref: MassMono: "163.087138" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:00104 name: L-proline amide def: "A protein modification that effectively converts an L-proline residue to L-proline amide." [PubMed:4982117, PubMed:5760861, RESID:AA0095] subset: PSI-MOD-slim synonym: "(2S)-pyrrolidine-2-carboxamide" EXACT RESID-systematic [] synonym: "amidated L-proline" EXACT PSI-MOD-alternate [] synonym: "L-proline amide" EXACT RESID-name [] synonym: "MOD_RES Proline amide" EXACT UniProt-feature [] synonym: "prolinamide" EXACT RESID-alternate [] synonym: "ProN" EXACT PSI-MOD-label [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 5 H 9 N 2 O 1" xref: MassAvg: "113.14" xref: MassMono: "113.071488" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:00105 name: L-serine amide def: "A protein modification that effectively converts an L-serine residue to L-serine amide." [PubMed:743209, RESID:AA0096] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-hydroxypropanamide" EXACT RESID-systematic [] synonym: "amidated L-serine" EXACT PSI-MOD-alternate [] synonym: "L-serine amide" EXACT RESID-name [] synonym: "MOD_RES Serine amide" EXACT UniProt-feature [] synonym: "serinamide" EXACT RESID-alternate [] synonym: "SerN" EXACT PSI-MOD-label [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 3 H 7 N 2 O 2" xref: MassAvg: "103.10" xref: MassMono: "103.050752" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00106 name: L-threonine amide def: "A protein modification that effectively converts an L-threonine residue to L-threonine amide." [PubMed:1390774, RESID:AA0097] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-hydroxybutanamide" EXACT RESID-systematic [] synonym: "amidated L-threonine" EXACT PSI-MOD-alternate [] synonym: "L-threonine amide" EXACT RESID-name [] synonym: "MOD_RES Threonine amide" EXACT UniProt-feature [] synonym: "threoninamide" EXACT RESID-alternate [] synonym: "ThrN" EXACT PSI-MOD-label [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 4 H 9 N 2 O 2" xref: MassAvg: "117.13" xref: MassMono: "117.066403" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00107 name: L-tryptophan amide def: "A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide." [PubMed:3947348, RESID:AA0098] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(1H-indol-3-yl)propanamide" EXACT RESID-systematic [] synonym: "amidated L-tryptophan" EXACT PSI-MOD-alternate [] synonym: "L-tryptophan amide" EXACT RESID-name [] synonym: "MOD_RES Tryptophan amide" EXACT UniProt-feature [] synonym: "TrpN" EXACT PSI-MOD-label [] synonym: "tryptophanamide" EXACT RESID-alternate [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 11 H 12 N 3 O 1" xref: MassAvg: "202.24" xref: MassMono: "202.098037" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00108 name: L-tyrosine amide def: "A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide." [PubMed:1377792, PubMed:3562898, PubMed:6509012, RESID:AA0099] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(4-hydoxyphenyl)propanamide" EXACT RESID-systematic [] synonym: "amidated L-tyrosine" EXACT PSI-MOD-alternate [] synonym: "L-tyrosine amide" EXACT RESID-name [] synonym: "MOD_RES Tyrosine amide" EXACT UniProt-feature [] synonym: "TyrN" EXACT PSI-MOD-label [] synonym: "tyrosinamide" EXACT RESID-alternate [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 9 H 11 N 2 O 2" xref: MassAvg: "179.20" xref: MassMono: "179.082053" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00109 name: L-valine amide def: "A protein modification that effectively converts an L-valine residue to L-valine amide." [PubMed:2578459, PubMed:5465996, RESID:AA0100] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-methylbutanamide" EXACT RESID-systematic [] synonym: "L-valine amide" EXACT RESID-name [] synonym: "MOD_RES Valine amide" EXACT UniProt-feature [] synonym: "valinamide" EXACT RESID-alternate [] synonym: "ValN" EXACT PSI-MOD-label [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 5 H 11 N 2 O 1" xref: MassAvg: "115.16" xref: MassMono: "115.087138" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00883 ! C1-amidated residue is_a: MOD:00920 ! modified L-valine residue [Term] id: MOD:00110 name: L-cysteine methyl disulfide def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide." [OMSSA:179, PubMed:10555576, PubMed:163643, PubMed:2056535, PubMed:6381494, RESID:AA0101, UniMod:39#C] comment: Produced artifactually by reaction of cysteine residues with methyl methanethiosulfonate (MMTS) [JSG]. synonym: "(2R)-2-amino-3-(methyldisulfanediyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(methyldisulfanediyl)propanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-(methyldithio)propanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-methyldisulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "2-azanyl-3-(methyldisulfanediyl)-propanoic acid" EXACT RESID-alternate [] synonym: "Beta-methylthiolation" RELATED UniMod-description [] synonym: "L-3-(methyldithio)alanine" EXACT RESID-alternate [] synonym: "L-cysteine methyl disulfide" EXACT RESID-name [] synonym: "methyl methanethiolsulfonate derivatized cysteine" EXACT PSI-MOD-alternate [] synonym: "methyl methanethiosulfonate derivatized cysteine" EXACT PSI-MOD-alternate [] synonym: "Methylthio" RELATED PSI-MS-label [] synonym: "Methylthio" RELATED UniMod-interim [] synonym: "mmts" EXACT OMSSA-label [] synonym: "MOD_RES Cysteine methyl disulfide" EXACT UniProt-feature [] synonym: "S-methylthio-L-cysteine" EXACT RESID-alternate [] synonym: "S-methylthiocysteine" EXACT RESID-alternate [] xref: DiffAvg: "46.09" xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1" xref: DiffMono: "45.987721" xref: Formula: "C 4 H 7 N 1 O 1 S 2" xref: MassAvg: "149.23" xref: MassMono: "148.996906" xref: Origin: "C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01153 ! methylthiolated residue is_a: MOD:01862 ! disulfide conjugated residue [Term] id: MOD:00111 name: S-farnesyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine." [DeltaMass:293, OMSSA:42, PubMed:1409665, PubMed:15609361, PubMed:1872463, PubMed:2684976, RESID:AA0102, UniMod:44#C] comment: From DeltaMass: (name misspelled "S-farnesyl cystenyl") subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid" EXACT RESID-alternate [] synonym: "Farnesyl" RELATED PSI-MS-label [] synonym: "Farnesylation" RELATED UniMod-description [] synonym: "farnesylationc" EXACT OMSSA-label [] synonym: "LIPID S-farnesyl cysteine" EXACT UniProt-feature [] synonym: "S-farnesyl Cystenyl" EXACT DeltaMass-label [] synonym: "S-farnesyl-L-cysteine" EXACT RESID-name [] synonym: "SFarnCys" EXACT PSI-MOD-label [] xref: DiffAvg: "204.36" xref: DiffFormula: "C 15 H 24 N 0 O 0 S 0" xref: DiffMono: "204.187801" xref: Formula: "C 18 H 29 N 1 O 1 S 1" xref: MassAvg: "307.50" xref: MassMono: "307.196986" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00437 ! farnesylated residue is_a: MOD:01110 ! isoprenylated cysteine [Term] id: MOD:00112 name: S-12-hydroxyfarnesyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine." [PubMed:17790543, RESID:AA0103, UniMod:376] synonym: "(2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid" EXACT RESID-alternate [] synonym: "Hydroxyfarnesyl" RELATED PSI-MS-label [] synonym: "hydroxyfarnesyl" RELATED UniMod-description [] synonym: "LIPID S-12-hydroxyfarnesyl cysteine" EXACT UniProt-feature [] synonym: "S-12-hydroxyfarnesyl-L-cysteine" EXACT RESID-name [] synonym: "S12HyFarnCys" EXACT PSI-MOD-label [] xref: DiffAvg: "220.36" xref: DiffFormula: "C 15 H 24 N 0 O 1 S 0" xref: DiffMono: "220.182715" xref: Formula: "C 18 H 29 N 1 O 2 S 1" xref: MassAvg: "323.50" xref: MassMono: "323.191900" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01110 ! isoprenylated cysteine [Term] id: MOD:00113 name: S-geranylgeranyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine." [DeltaMass:0, OMSSA:49, PubMed:1483450, PubMed:15609361, RESID:AA0104, UniMod:48#C] comment: DeltaMass calculates the mass with two double bonds rather than four subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid" EXACT RESID-alternate [] synonym: "Geranyl-geranyl" RELATED UniMod-description [] synonym: "GeranylGeranyl" RELATED PSI-MS-label [] synonym: "geranylgeranylc" EXACT OMSSA-label [] synonym: "LIPID S-geranylgeranyl cysteine" EXACT UniProt-feature [] synonym: "S-geranylgeranyl" EXACT DeltaMass-label [] synonym: "S-geranylgeranyl-L-cysteine" EXACT RESID-name [] synonym: "SGergerCys" EXACT PSI-MOD-label [] xref: DiffAvg: "272.48" xref: DiffFormula: "C 20 H 32 N 0 O 0 S 0" xref: DiffMono: "272.250401" xref: Formula: "C 23 H 37 N 1 O 1 S 1" xref: MassAvg: "375.62" xref: MassMono: "375.259586" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00441 ! geranylgeranylated residue is_a: MOD:01110 ! isoprenylated cysteine [Term] id: MOD:00114 name: L-cysteine methyl ester def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester." [PubMed:11875433, PubMed:1872463, RESID:AA0105, UniMod:34#C-term] comment: Secondary to RESID:AA0102; secondary to RESID:AA0103; secondary to RESID:AA0104. subset: PSI-MOD-slim synonym: "2-amino-3-mercaptopropanoic methyl ester" EXACT RESID-alternate [] synonym: "2-amino-3-sulfanylpropanoic methyl ester" EXACT RESID-alternate [] synonym: "L-cysteine methyl ester" EXACT RESID-name [] synonym: "mecysteine" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic [] synonym: "methyl esterified L-cysteine" EXACT PSI-MOD-alternate [] synonym: "methyl L-cysteinate" EXACT RESID-alternate [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES Cysteine methyl ester" EXACT UniProt-feature [] synonym: "OMeCys" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0" xref: DiffMono: "14.015650" xref: Formula: "C 4 H 8 N 1 O 2 S 1" xref: MassAvg: "134.17" xref: MassMono: "134.027574" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01682 ! monomethylated L-cysteine is_a: MOD:01689 ! alpha-carboxyl methylated residue [Term] id: MOD:00115 name: S-palmitoyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine." [DeltaMass:303, PubMed:1872406, PubMed:3166978, PubMed:8180229, PubMed:8824274, RESID:AA0106, UniMod:47#C] comment: From DeltaMass: (name misspelled "S-palmityl Cystenyl" and formula incorrect, N and O reversed) Formula: C19H35O1N2S1 Monoisotopic Mass Change: 341.239 Average Mass Change: 341.556 subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(hexadecanoylthio)propanoic acid" EXACT RESID-alternate [] synonym: "ACT_SITE S-palmitoyl cysteine intermediate" EXACT UniProt-feature [] synonym: "cysteine hexadecanoate thioester" EXACT RESID-alternate [] synonym: "cysteine palmitate thioester" EXACT RESID-alternate [] synonym: "LIPID S-palmitoyl cysteine" EXACT UniProt-feature [] synonym: "Palmitoyl" RELATED PSI-MS-label [] synonym: "Palmitoylation" RELATED UniMod-description [] synonym: "S-palmitoyl-L-cysteine" EXACT RESID-name [] synonym: "S-palmitoylated L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S-palmityl Cystenyl" EXACT DeltaMass-label [] synonym: "SPamCys" EXACT PSI-MOD-label [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" xref: DiffMono: "238.229666" xref: Formula: "C 19 H 35 N 1 O 2 S 1" xref: MassAvg: "341.55" xref: MassMono: "341.238850" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00653 ! S-palmitoylated residue is_a: MOD:01684 ! palmitoylated-L-cysteine [Term] id: MOD:00116 name: S-diacylglycerol-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107, UniMod:377#C] comment: Incidental to RESID:AA0060. subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid" EXACT RESID-alternate [] synonym: "Diacylglycerol" RELATED PSI-MS-label [] synonym: "diacylglycerol" RELATED UniMod-description [] synonym: "LIPID S-diacylglycerol cysteine" EXACT UniProt-feature [] synonym: "S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine" EXACT RESID-alternate [] synonym: "S-(2',3'-diacylglycerol)-L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S-diacylglycerol-L-cysteine" EXACT RESID-name [] synonym: "SAcyl2GlyceroCys" EXACT PSI-MOD-label [] xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00117 name: S-(L-isoglutamyl)-L-cysteine def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia." [ChEBI:22021, DeltaMass:0, PubMed:6838833, RESID:AA0108] comment: Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine. subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid" EXACT RESID-alternate [] synonym: "2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln)" EXACT UniProt-feature [] synonym: "gamma-(S-cysteinyl)glutamic acid" EXACT RESID-alternate [] synonym: "S-(L-isoglutamyl)-L-cysteine" EXACT RESID-name [] synonym: "S-gamma-glutamyl (crosslinked to cysteine)" EXACT DeltaMass-label [] synonym: "XLNK-SCys-5Glu(Gln)" EXACT PSI-MOD-label [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0" xref: DiffMono: "-17.026549" xref: Formula: "C 8 H 10 N 2 O 3 S 1" xref: MassAvg: "214.24" xref: MassMono: "214.041213" xref: Origin: "C, Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:00946 ! crosslinked residues with loss of ammonia [Term] id: MOD:00118 name: 2'-(S-L-cysteinyl)-L-histidine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine." [DeltaMass:0, PubMed:6210696, RESID:AA0109] comment: Cross-link 2. synonym: "(2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid" EXACT RESID-systematic [] synonym: "(2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-alternate [] synonym: "2'-(L-cystein-S-yl)-L-histidine" EXACT RESID-name [] synonym: "CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His)" EXACT UniProt-feature [] synonym: "S-(2'-histidyl)cysteine" EXACT RESID-alternate [] synonym: "S-(2-histidyl)- (crosslinked to cysteine)" EXACT DeltaMass-label [] synonym: "XLNK-SCys-2'His" EXACT PSI-MOD-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 9 H 10 N 4 O 2 S 1" xref: MassAvg: "238.26" xref: MassMono: "238.052447" xref: Origin: "C, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00687 ! thioether crosslinked residues is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00119 name: L-lanthionine (Cys-Ser) def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine." [ChEBI:21347, DeltaMass:7, RESID:AA0110#CSX] comment: Cross-link 2. The natural occurrence of this modification is rare. For the more common modification see MOD:00120 meso-lanthionine [JSG]. synonym: "(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "(R)-S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT RESID-alternate [] synonym: "(R,R)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate [] synonym: "(R,R)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "(R,R)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate [] synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "3,3'-thiobis-L-alanine" EXACT RESID-alternate [] synonym: "L-lanthionine" EXACT RESID-name [] synonym: "XLNK-SCys-(L)3Dha" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 8 N 2 O 2 S 1" xref: MassAvg: "172.20" xref: MassMono: "172.030649" xref: Origin: "C, S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01839 ! L-lanthionine [Term] id: MOD:00120 name: meso-lanthionine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine." [PubMed:15023056, PubMed:3769923, RESID:AA0111] comment: Cross-link 2. synonym: "(2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "(2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "(2R,6S)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate [] synonym: "(2R,6S)-meso-lanthionine" EXACT RESID-alternate [] synonym: "(2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid" EXACT RESID-alternate [] synonym: "(2S,6R)-meso-lanthionine" RELATED RESID-misnomer [] synonym: "(R)-S-(2-amino-2-carboxyethyl)-D-cysteine" EXACT RESID-alternate [] synonym: "(R,S)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate [] synonym: "3,3'-thiobis-meso-alanine" EXACT RESID-alternate [] synonym: "CROSSLNK Lanthionine (Cys-Ser)" EXACT UniProt-feature [] synonym: "CROSSLNK Lanthionine (Ser-Cys)" EXACT UniProt-feature [] synonym: "cysteine-3-D-alanine thioether" EXACT RESID-alternate [] synonym: "meso-lanthionine" EXACT RESID-name [] synonym: "XLNK-SCys-(D)3Dha" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 8 N 2 O 2 S 1" xref: MassAvg: "172.20" xref: MassMono: "172.030649" xref: Origin: "C, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01841 ! lanthionine [Term] id: MOD:00121 name: (2S,3S,2'R)-3-methyllanthionine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine." [PubMed:3769923, RESID:AA0112] comment: Cross-link 2. synonym: "(2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "(2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate [] synonym: "(2S,3S,2'R)-3-methyllanthionine" EXACT RESID-name [] synonym: "(2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT RESID-alternate [] synonym: "(2S,3S,6R)-3-methyllanthionine" EXACT RESID-alternate [] synonym: "(2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate [] synonym: "3-methyl-D,L-lanthionine" EXACT RESID-alternate [] synonym: "CROSSLNK Beta-methyllanthionine (Cys-Thr)" EXACT UniProt-feature [] synonym: "CROSSLNK Beta-methyllanthionine (Thr-Cys)" EXACT UniProt-feature [] synonym: "cysteine-3-D-butyrine thioether" EXACT RESID-alternate [] synonym: "XLNK-SCys-3Dhb" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 7 H 10 N 2 O 2 S 1" xref: MassAvg: "186.23" xref: MassMono: "186.046299" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01981 ! 3-methyllanthionine [Term] id: MOD:00122 name: 3'-(S-L-cysteinyl)-L-tyrosine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine." [DeltaMass:0, PubMed:15917234, PubMed:2002850, RESID:AA0113] comment: Cross-link 2. synonym: "(2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid" EXACT RESID-alternate [] synonym: "3'-(cystein-S-yl)tyrosine" EXACT RESID-alternate [] synonym: "3'-(L-cystein-S-yl)-L-tyrosine" EXACT RESID-name [] synonym: "CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" EXACT UniProt-feature [] synonym: "CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys)" EXACT UniProt-feature [] synonym: "S-(3-Tyr) (Crosslinked to Cysteine)" EXACT DeltaMass-label [] synonym: "S-(tyros-3'-yl)cysteine" EXACT RESID-alternate [] synonym: "XLNK-SCys-3'Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 12 H 12 N 2 O 3 S 1" xref: MassAvg: "264.30" xref: MassMono: "264.056863" xref: Origin: "C, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00687 ! thioether crosslinked residues is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00123 name: N6-carboxy-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine." [PubMed:11369851, PubMed:4436319, PubMed:637859, PubMed:7754395, RESID:AA0114, UniMod:299#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(carboxyamino)hexanoic acid" EXACT RESID-systematic [] synonym: "2-amino-6-carbamic hexanoic acid" EXACT RESID-alternate [] synonym: "Carboxy" RELATED UniMod-interim [] synonym: "Carboxylation" RELATED UniMod-description [] synonym: "lysine NZ-carboxylic acid" EXACT RESID-alternate [] synonym: "MOD_RES N6-carboxylysine" EXACT UniProt-feature [] synonym: "N6-carbamyllysine" RELATED RESID-misnomer [] synonym: "N6-carboxy-L-lysine" EXACT RESID-name [] synonym: "N6-carboxylysine" EXACT RESID-alternate [] synonym: "N6CbxLys" EXACT PSI-MOD-label [] xref: DiffAvg: "44.01" xref: DiffFormula: "C 1 H 0 N 0 O 2" xref: DiffMono: "43.989829" xref: Formula: "C 7 H 12 N 2 O 3" xref: MassAvg: "172.18" xref: MassMono: "172.084792" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01152 ! carboxylated residue [Term] id: MOD:00124 name: N6-1-carboxyethyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine." [PubMed:3123486, PubMed:8253186, PubMed:8421682, RESID:AA0115, UniMod:378#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "Carboxyethyl" RELATED PSI-MS-label [] synonym: "carboxyethyl" RELATED UniMod-description [] synonym: "MOD_RES N6-1-carboxyethyl lysine" EXACT UniProt-feature [] synonym: "N6-(1-carboxyethyl)-L-lysine" EXACT RESID-name [] synonym: "N6-(1-carboxyethyl)lysine" EXACT RESID-alternate [] synonym: "N6CbzEtLys" EXACT PSI-MOD-label [] synonym: "NZ-(1-carboxyethyl)lysine" EXACT RESID-alternate [] xref: DiffAvg: "72.06" xref: DiffFormula: "C 3 H 4 N 0 O 2" xref: DiffMono: "72.021129" xref: Formula: "C 9 H 16 N 2 O 3" xref: MassAvg: "200.24" xref: MassMono: "200.116092" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00125 name: hypusine def: "A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [DeltaMass:0, PubMed:6806267, PubMed:8108861, RESID:AA0116, UniMod:379#K] comment: This modification occurs uniquely in translation initiation factor eIF-5A [JSG]. subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "(2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid" EXACT RESID-alternate [] synonym: "(2S,9R)-hypusine" EXACT RESID-alternate [] synonym: "2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid" EXACT RESID-alternate [] synonym: "Hypu" EXACT PSI-MOD-label [] synonym: "Hypusine" RELATED PSI-MS-label [] synonym: "hypusine" RELATED UniMod-description [] synonym: "L-hypusine" EXACT RESID-name [] synonym: "MOD_RES Hypusine" EXACT UniProt-feature [] synonym: "N-(4-NH2-2-OH-butyl)- (of Lysine)" EXACT DeltaMass-label [] synonym: "N6-(4-amino-2-hydroxybutyl)-L-lysine" EXACT RESID-alternate [] xref: DiffAvg: "87.12" xref: DiffFormula: "C 4 H 9 N 1 O 1" xref: DiffMono: "87.068414" xref: Formula: "C 10 H 21 N 3 O 2" xref: MassAvg: "215.30" xref: MassMono: "215.163377" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01884 ! 4-aminobutylated residue relationship: derives_from MOD:01880 ! L-deoxyhypusine [Term] id: MOD:00126 name: N6-biotinyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine." [DeltaMass:305, PubMed:16109483, PubMed:3178228, PubMed:7948875, PubMed:8747466, RESID:AA0117, UniMod:3#K] comment: From DeltaMass: Average Mass: 354 Formula:C 16 H 26 O 4 N 3 S 1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:354.172 Average Mass Change:354.471 References:PE Sciex. subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoylamino)hexanoic acid" EXACT RESID-systematic [] synonym: "(3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine" EXACT RESID-alternate [] synonym: "biocytin" EXACT RESID-alternate [] synonym: "Biotin" RELATED PSI-MS-label [] synonym: "biotinyl lysyl" EXACT DeltaMass-label [] synonym: "Biotinylation" RELATED UniMod-description [] synonym: "epsilon-N-biotinyllysine" EXACT RESID-alternate [] synonym: "MOD_RES N6-biotinyllysine" EXACT UniProt-feature [] synonym: "N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine" EXACT RESID-alternate [] synonym: "N6-biotinyl-L-lysine" EXACT RESID-name [] synonym: "N6-biotinyllysine" EXACT RESID-alternate [] synonym: "N6BtnLys" EXACT PSI-MOD-label [] xref: DiffAvg: "226.29" xref: DiffFormula: "C 10 H 14 N 2 O 2 S 1" xref: DiffMono: "226.077599" xref: Formula: "C 16 H 26 N 4 O 3 S 1" xref: MassAvg: "354.47" xref: MassMono: "354.172562" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01875 ! N6-acylated L-lysine is_a: MOD:01885 ! biotinylated residue [Term] id: MOD:00127 name: N6-lipoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine." [DeltaMass:0, OMSSA:67, PubMed:3421911, PubMed:3522581, PubMed:7719855, RESID:AA0118, UniMod:42#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(5-[(3R)-1,2-dithiolan-3-yl]pentanamido)hexanoic acid" EXACT RESID-alternate [] synonym: "(2S)-2-amino-6-[(5-[(3R)-1,2-dithiolan-3-yl]pentanoyl)amino]hexanoic acid" EXACT RESID-systematic [] synonym: "(2S,6'R)-2-amino-6-(6,8-dithiooctanamido)hexanoic acid" EXACT RESID-alternate [] synonym: "2-amino-6-(5-[1,2-dithiolan-3-yl]-1-oxopentyl)aminohexanoic acid" EXACT RESID-alternate [] synonym: "Lipoyl" RELATED PSI-MS-label [] synonym: "Lipoyl" RELATED UniMod-description [] synonym: "lipoylk" EXACT OMSSA-label [] synonym: "MOD_RES N6-lipoyllysine" EXACT UniProt-feature [] synonym: "N-Lipoyl- (on Lysine)" EXACT DeltaMass-label [] synonym: "N6-6,8-dithiooctanoyllysine" EXACT RESID-alternate [] synonym: "N6-lipoyl-L-lysine" EXACT RESID-name [] synonym: "N6-lipoyllysine" EXACT RESID-alternate [] synonym: "N6LipLys" EXACT PSI-MOD-label [] xref: DiffAvg: "188.30" xref: DiffFormula: "C 8 H 12 N 0 O 1 S 2" xref: DiffMono: "188.032957" xref: Formula: "C 14 H 24 N 2 O 2 S 2" xref: MassAvg: "316.48" xref: MassMono: "316.127920" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:00128 name: N6-pyridoxal phosphate-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine." [DeltaMass:0, PubMed:1544460, RESID:AA0119, UniMod:46#K] comment: From DeltaMass: Average Mass: 231 subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-[([3-hydroxy-2-methyl-5-phosphonooxymethylpyridin-4-yl]methylidene)amino]hexanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES N6-(pyridoxal phosphate)lysine" EXACT UniProt-feature [] synonym: "N6-pyridoxal phosphate-L-lysine" EXACT RESID-name [] synonym: "N6PydoxLys" EXACT PSI-MOD-label [] synonym: "Pyridoxal phosphate" RELATED UniMod-description [] synonym: "Pyridoxal phosphate (Schiff Base formed to lysine)" EXACT DeltaMass-label [] synonym: "PyridoxalPhosphate" RELATED PSI-MS-label [] xref: DiffAvg: "229.13" xref: DiffFormula: "C 8 H 8 N 1 O 5 P 1" xref: DiffMono: "229.014009" xref: Formula: "C 14 H 20 N 3 O 6 P 1" xref: MassAvg: "357.30" xref: MassMono: "357.108972" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00129 name: N6-retinylidene-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine, the adduct of retinal." [PubMed:6794028, PubMed:6870827, RESID:AA0120, UniMod:380#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES N6-(retinylidene)lysine" EXACT UniProt-feature [] synonym: "N6-retinal-L-lysine" EXACT RESID-alternate [] synonym: "N6-retinyl-lysine" EXACT RESID-alternate [] synonym: "N6-retinylidene-L-lysine" EXACT RESID-name [] synonym: "N6RetalLys" EXACT PSI-MOD-label [] synonym: "retinal" RELATED UniMod-description [] synonym: "Retinylidene" RELATED PSI-MS-label [] xref: DiffAvg: "266.43" xref: DiffFormula: "C 20 H 26 N 0 O 0" xref: DiffMono: "266.203451" xref: Formula: "C 26 H 38 N 2 O 1" xref: MassAvg: "394.60" xref: MassMono: "394.298414" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00130 name: L-allysine def: "A protein modification that effectively converts an L-lysine residue to L-allysine." [ChEBI:17917, DeltaMass:0, PubMed:11120890, PubMed:11332453, PubMed:358196, PubMed:5337886, PubMed:5529814, RESID:AA0121, UniMod:352#K] comment: From DeltaMass: Average Mass: -1 subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-oxohexanoic acid" EXACT RESID-systematic [] synonym: "2-amino-5-formylvaleric acid" EXACT RESID-alternate [] synonym: "2-amino-adipic acid semialdahyde" EXACT RESID-alternate [] synonym: "2-aminoadipate 6-semialdehyde" EXACT RESID-alternate [] synonym: "5-formyl-norvaline" EXACT RESID-alternate [] synonym: "6-oxonorleucine" EXACT RESID-alternate [] synonym: "AASA" EXACT RESID-alternate [] synonym: "Allysine (from Lysine)" EXACT DeltaMass-label [] synonym: "alpha-amino-adipic acid delta-semialdahyde" EXACT RESID-alternate [] synonym: "L-allysine" EXACT RESID-name [] synonym: "Lys->Allysine" RELATED PSI-MS-label [] synonym: "Lysal" EXACT PSI-MOD-label [] synonym: "Lysine oxidation to aminoadipic semialdehyde" RELATED UniMod-description [] synonym: "MOD_RES Allysine" EXACT UniProt-feature [] synonym: "Oxidation of lysine (to aminoadipic semialdehyde)" EXACT DeltaMass-label [] xref: DiffAvg: "-1.03" xref: DiffFormula: "C 0 H -3 N -1 O 1" xref: DiffMono: "-1.031634" xref: Formula: "C 6 H 9 N 1 O 2" xref: MassAvg: "127.14" xref: MassMono: "127.063329" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00131 name: L-2-aminoadipic acid def: "A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid." [DeltaMass:353, PubMed:336041, PubMed:358196, PubMed:7419498, RESID:AA0122, UniMod:381#K] comment: From DeltaMass: References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. [This has been observed as a natural modification, see RESID:AA0122. JSG] subset: PSI-MOD-slim synonym: "(2S)-2-aminohexanedioic acid" EXACT RESID-systematic [] synonym: "2-amino-1,4-butanedicarboxylic acid" EXACT RESID-alternate [] synonym: "alpha-amino adipic acid" RELATED UniMod-description [] synonym: "L-2-aminoadipic acid" EXACT RESID-name [] synonym: "L-alpha-aminoadipic acid" EXACT RESID-alternate [] synonym: "Lys->AminoadipicAcid" RELATED PSI-MS-label [] synonym: "Lysoic" EXACT PSI-MOD-label [] synonym: "Oxidation of lysine (to aminoadipic acid)" EXACT DeltaMass-label [] xref: DiffAvg: "14.97" xref: DiffFormula: "C 0 H -3 N -1 O 2" xref: DiffMono: "14.963280" xref: Formula: "C 6 H 9 N 1 O 3" xref: MassAvg: "143.14" xref: MassMono: "143.058243" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00132 name: L-lysinoalanine (Lys-Ser) def: "A protein modification that effectively crosslinks an L-serine residue and an L-lysine residue to release water and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid." [DeltaMass:0, PubMed:2544544, RESID:AA0123#KSX] comment: Cross-link 2. This entry is for the crosslink of peptidyl serine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34. synonym: "(2R,9S)-lysinoalanine" EXACT RESID-alternate [] synonym: "(2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "alaninolysine" EXACT RESID-alternate [] synonym: "CROSSLNK Lysinoalanine (Ser-Lys)" EXACT UniProt-feature [] synonym: "L-lysinoalanine" EXACT RESID-name [] synonym: "LAL" EXACT RESID-alternate [] synonym: "Lysinoalanine (from Cysteine)" EXACT DeltaMass-label [] synonym: "N-epsilon-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate [] synonym: "XLNK-N6Lys-3Dha(Ser)" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 9 H 15 N 3 O 2" xref: MassAvg: "197.24" xref: MassMono: "197.116427" xref: Origin: "K, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01853 ! L-lysinoalanine [Term] id: MOD:00133 name: N6-(L-isoglutamyl)-L-lysine (Gln) def: "A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoglutamyl)-L-lysine and the release of ammonia." [ChEBI:21863, DeltaMass:0, PubMed:2461365, PubMed:5637041, PubMed:5656070, PubMed:8598899, RESID:AA0124#GLN] comment: Cross-link 2. subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate [] synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate [] synonym: "CROSSLNK Isoglutamyl lysine isopeptide (Lys-Gln)" EXACT UniProt-feature [] synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label [] synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate [] synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name [] synonym: "XLNK-N6Lys-5Glu(Gln)" EXACT PSI-MOD-label [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 11 H 17 N 3 O 3" xref: MassAvg: "239.27" xref: MassMono: "239.126991" xref: Origin: "K, Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:00946 ! crosslinked residues with loss of ammonia is_a: MOD:01630 ! N6-(L-isoglutamyl)-L-lysine [Term] id: MOD:00134 name: N6-glycyl-L-lysine def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine." [ChEBI:21885, RESID:AA0125] comment: Cross-link 2; this is the common crosslink structure formed by ubiquitin, SUMO, and similar proteins. subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid" EXACT RESID-systematic [] synonym: "N6-(glycyl)-L-lysine" EXACT RESID-name [] synonym: "N6-glycyllysine" EXACT RESID-alternate [] synonym: "XLNK-N6Lys-1Gly" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 8 H 14 N 3 O 2" xref: MassAvg: "184.22" xref: MassMono: "184.108602" xref: Origin: "G, K" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00688 ! isopeptide crosslinked residues is_a: MOD:00908 ! modified glycine residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:00135 name: N-(L-isoaspartyl)-glycine (Asn) def: "A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine and the release of ammonia." [ChEBI:21479, PubMed:1826288, RESID:AA0126] comment: Cross-link 2. synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Asn-Gly)" EXACT UniProt-feature [] synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asn)" EXACT UniProt-feature [] synonym: "isoaspartyl glycine" EXACT RESID-alternate [] synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name [] synonym: "N-beta-aspartylglycine" EXACT RESID-alternate [] synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate [] synonym: "XLNK-4Asp-NGly(Asn)" EXACT PSI-MOD-label [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 6 H 7 N 2 O 3" xref: MassAvg: "155.13" xref: MassMono: "155.045667" xref: Origin: "G, N" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:00946 ! crosslinked residues with loss of ammonia is_a: MOD:01928 ! N-(L-isoaspartyl)-glycine [Term] id: MOD:00136 name: pyruvic acid (Cys) def: "A protein modification that effectively converts an L-cysteine residue to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127#CYS, UniMod:382] subset: PSI-MOD-slim synonym: "2-oxopropanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES Pyruvic acid (Cys)" EXACT UniProt-feature [] synonym: "Pyruv(Cys)" EXACT PSI-MOD-label [] synonym: "pyruvic acid" EXACT RESID-name [] xref: DiffAvg: "-33.09" xref: DiffFormula: "C 0 H -3 N -1 O 1 S -1" xref: DiffMono: "-33.003705" xref: Formula: "C 3 H 3 O 2" xref: MassAvg: "71.06" xref: MassMono: "71.013304" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01154 ! pyruvic acid [Term] id: MOD:00137 name: L-3-phenyllactic acid def: "A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid." [PubMed:1973541, RESID:AA0128, UniMod:7#F] comment: This modification is not the result of deamidation, instead the alpha amino group is replaced with an hydroxyl group. synonym: "(2S)-2-hydroxy-3-phenylpropanoic acid" EXACT RESID-systematic [] synonym: "Deamidated" RELATED UniMod-interim [] synonym: "Deamidation" RELATED UniMod-description [] synonym: "L-3-phenyllactic acid" EXACT RESID-name [] synonym: "MOD_RES 3-phenyllactic acid" EXACT UniProt-feature [] xref: DiffAvg: "0.98" xref: DiffFormula: "C 0 H -1 N -1 O 1" xref: DiffMono: "0.984016" xref: Formula: "C 9 H 9 O 2" xref: MassAvg: "149.17" xref: MassMono: "149.060255" xref: Origin: "F" xref: TermSpec: "N-term" is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:00138 name: 2-oxobutanoic acid def: "A protein modification that effectively converts an L-threonine residue into 2-oxobutanoic acid." [PubMed:15023056, PubMed:1680314, PubMed:2253617, PubMed:2764678, RESID:AA0129, UniMod:385#T] synonym: "2-ketobutyric acid" EXACT RESID-alternate [] synonym: "2-oxobutanoic acid" EXACT RESID-name [] synonym: "2-oxobutanoic acid" EXACT RESID-systematic [] synonym: "2-oxobutyric acid" EXACT RESID-alternate [] synonym: "Ammonia-loss" RELATED UniMod-interim [] synonym: "Loss of ammonia" RELATED UniMod-description [] synonym: "MOD_RES 2-oxobutanoic acid" EXACT UniProt-feature [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 4 H 5 O 2" xref: MassAvg: "85.08" xref: MassMono: "85.028954" xref: Origin: "T" xref: TermSpec: "N-term" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01160 ! deaminated residue [Term] id: MOD:00139 name: N2-succinyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan." [PubMed:11857757, PubMed:12175151, PubMed:8471040, RESID:AA0130, UniMod:64#N-term] synonym: "(2S)-2-(3-carboxypropanoyl)amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "(2S)-2-amino-(6,7-dihydro-6,7-dioxo-1H-indole)-3-propanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N2-succinyltryptophan" EXACT UniProt-feature [] synonym: "N2-succinyl-L-tryptophan" EXACT RESID-name [] synonym: "Succinic anhydride labeling reagent light form (N-term)" RELATED UniMod-description [] synonym: "Succinyl" RELATED PSI-MS-label [] xref: DiffAvg: "100.07" xref: DiffFormula: "C 4 H 4 N 0 O 3" xref: DiffMono: "100.016044" xref: Formula: "C 15 H 15 N 2 O 4" xref: MassAvg: "287.29" xref: MassMono: "287.103182" xref: Origin: "W" xref: TermSpec: "N-term" is_a: MOD:00457 ! alpha-amino succinylated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00140 name: S-phycocyanobilin-L-cysteine def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycocyanobilin." [ChEBI:15617, DeltaMass:0, PubMed:16644722, PubMed:3208761, PubMed:3838747, PubMed:7918400, RESID:AA0131, UniMod:387#C] comment: From DeltaMass: Average Mass: 587. synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-ethyl-1,2,3,19,21,22,24-heptahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate [] synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] synonym: "BINDING Phycocyanobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] synonym: "PCB" EXACT RESID-alternate [] synonym: "phycobilin cysteine" EXACT RESID-alternate [] synonym: "Phycocyanobilin" RELATED PSI-MS-label [] synonym: "phycocyanobilin" RELATED UniMod-description [] synonym: "phycocyanobilin cysteine adduct" EXACT RESID-alternate [] synonym: "S-Phycocyanobilin (on Cysteine)" EXACT DeltaMass-label [] synonym: "S-phycocyanobilin-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "586.69" xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" xref: DiffMono: "586.279135" xref: Formula: "C 36 H 43 N 5 O 7 S 1" xref: MassAvg: "689.83" xref: MassMono: "689.288320" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00141 name: S-phycoerythrobilin-L-cysteine def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoerythrobilin." [ChEBI:15618, PubMed:14588022, PubMed:3208761, PubMed:3838747, PubMed:8876649, RESID:AA0132, UniMod:388#C] synonym: "(2S,3R,16R)-18-ethenyl-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] synonym: "18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate [] synonym: "BINDING Phycoerythrobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] synonym: "PEB" EXACT RESID-alternate [] synonym: "Phycoerythrobilin" RELATED PSI-MS-label [] synonym: "phycoerythrobilin" RELATED UniMod-description [] synonym: "phycoerythrobilin cysteine adduct" EXACT RESID-alternate [] synonym: "S-phycoerythrobilin-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "588.70" xref: DiffFormula: "C 33 H 40 N 4 O 6 S 0" xref: DiffMono: "588.294785" xref: Formula: "C 36 H 45 N 5 O 7 S 1" xref: MassAvg: "691.84" xref: MassMono: "691.303970" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00142 name: S-phytochromobilin-L-cysteine def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phytochromobilin." [ChEBI:15619, PubMed:1634523, PubMed:16593380, PubMed:3208761, PubMed:7918400, RESID:AA0133, UniMod:389#C] synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] synonym: "18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" EXACT RESID-alternate [] synonym: "BINDING Phytochromobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] synonym: "phytochrome chromophore" EXACT RESID-alternate [] synonym: "Phytochromobilin" RELATED PSI-MS-label [] synonym: "phytochromobilin" RELATED UniMod-description [] synonym: "phytochromobilin cysteine adduct" EXACT RESID-alternate [] synonym: "S-phytochromobilin-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "584.67" xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0" xref: DiffMono: "584.263485" xref: Formula: "C 36 H 41 N 5 O 7 S 1" xref: MassAvg: "687.81" xref: MassMono: "687.272670" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00143 name: heme-bis-L-cysteine def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [ChEBI:17627, PubMed:5545094, PubMed:8827449, RESID:AA0134] comment: Cross-link 2. subset: PSI-MOD-slim synonym: "(7,12-bis[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate" EXACT RESID-systematic [] synonym: "2,4-bis[1-(S-cysteinyl)ethyl]protoporphyrin IX" EXACT RESID-alternate [] synonym: "BINDING Heme (covalent)" EXACT UniProt-feature [] synonym: "biscysteinyl heme" EXACT RESID-alternate [] synonym: "heme-bis-L-cysteine" EXACT RESID-name [] synonym: "HemeCys2" EXACT PSI-MOD-label [] xref: DiffAvg: "616.50" xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4 S 0" xref: DiffMono: "616.177293" xref: Formula: "C 40 Fe 1 H 42 N 6 O 6 S 2" xref: MassAvg: "822.78" xref: MassMono: "822.195663" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00144 name: heme-L-cysteine def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [ChEBI:17627, DeltaMass:0, PubMed:170910, PubMed:192772, PubMed:2536325, PubMed:9535866, RESID:AA0135, UniMod:390#C] comment: From DeltaMass: Average Mass: 617. subset: PSI-MOD-slim synonym: "(12-ethenyl-7-[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate" EXACT RESID-systematic [] synonym: "4-[1-(S-cysteinyl)ethyl]protoporphyrin IX" EXACT RESID-alternate [] synonym: "BINDING Heme (covalent; via 1 link)" EXACT UniProt-feature [] synonym: "cysteinyl heme" EXACT RESID-alternate [] synonym: "Heme" RELATED PSI-MS-label [] synonym: "heme" RELATED UniMod-description [] synonym: "heme-L-cysteine" EXACT RESID-name [] synonym: "HemeCys1" EXACT PSI-MOD-label [] synonym: "S-Heme (on Cysteine)" EXACT DeltaMass-label [] xref: DiffAvg: "616.50" xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4 S 0" xref: DiffMono: "616.177293" xref: Formula: "C 37 Fe 1 H 37 N 5 O 5 S 1" xref: MassAvg: "719.64" xref: MassMono: "719.186478" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00145 name: tetrakis-L-cysteinyl iron def: "A protein modification that effectively converts four L-cysteine residues iron atom to tetrakis-L-cysteinyl iron." [PubMed:1303768, PubMed:2244884, RESID:AA0136] comment: Cross-link 4. synonym: "METAL Iron" EXACT UniProt-feature [] synonym: "tetrakis(cysteinato-kappaS)-iron" EXACT RESID-systematic [] synonym: "tetrakis-L-cysteinyl iron" EXACT RESID-name [] xref: DiffAvg: "51.81" xref: DiffFormula: "C 0 Fe 1 H -4 N 0 O 0 S 0" xref: DiffMono: "51.904735" xref: FormalCharge: "2-" xref: Formula: "C 12 Fe 1 H 16 N 4 O 4 S 4" xref: MassAvg: "464.37" xref: MassMono: "463.941474" xref: Origin: "C, C, C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00738 ! iron containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00146 name: tetrakis-L-cysteinyl diiron disulfide def: "A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to tetrakis-L-cysteinyl diiron disulfide." [PubMed:2123937, PubMed:6801028, PubMed:7763242, PubMed:8688437, RESID:AA0137] comment: Cross-link 4. synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] synonym: "METAL Iron-sulfur (2Fe-2S); shared with dimeric partner" EXACT UniProt-feature [] synonym: "tetrakis-L-cysteinyl diiron disulfide" EXACT RESID-name [] synonym: "tetrakiscysteinato-1kappa(2)S,2kappa(2)S-di-mu-sulfido-diiron" EXACT RESID-systematic [] xref: DiffAvg: "171.78" xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2" xref: DiffMono: "171.783814" xref: FormalCharge: "2-" xref: Formula: "C 12 Fe 2 H 16 N 4 O 4 S 6" xref: MassAvg: "584.34" xref: MassMono: "583.820553" xref: Origin: "C, C, C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00147 name: hexakis-L-cysteinyl triiron trisulfide def: "A protein modification that effectively converts six L-cysteine residues and a three-iron three-sulfur cluster to hexakis-L-cysteinyl triiron trisulfide." [PubMed:3379067, PubMed:3932661, PubMed:7354058, RESID:AA0138] comment: Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "hexakis-L-cysteinyl triiron trisulfide" EXACT RESID-name [] synonym: "tri-mu-sulfido-hexakiscysteinato-1kappa(2)S,2kappa(2)S,3kappa(2)S-triiron" EXACT RESID-systematic [] synonym: "tri-mu-sulfidotris(biscysteinato-kappaS-iron)" EXACT RESID-alternate [] xref: DiffAvg: "257.67" xref: DiffFormula: "C 0 Fe 3 H -6 N 0 O 0 S 3" xref: DiffMono: "257.675721" xref: FormalCharge: "3-" xref: Formula: "C 18 Fe 3 H 24 N 6 O 6 S 9" xref: MassAvg: "876.50" xref: MassMono: "875.730830" xref: Origin: "C, C, C, C, C, C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00148 name: tris-L-cysteinyl triiron tetrasulfide def: "A protein modification that effectively converts three L-cysteine residues and a three-iron four-sulfur cluster to tris-L-cysteinyl triiron tetrasulfide." [PubMed:10555576, PubMed:2056535, PubMed:3422475, PubMed:6848518, PubMed:7819255, PubMed:9063899, RESID:AA0139] comment: Cross-link 3. synonym: "METAL Iron-sulfur (3Fe-4S)" EXACT UniProt-feature [] synonym: "mu3-sulfido tri-mu-sulfido tris-S-L-cysteinyl triiron" EXACT RESID-alternate [] synonym: "mu3-sulfido-tri-mu-sulfido-triscysteinato-1kappaS,2kappaS,3kappaS-triiron" EXACT RESID-systematic [] synonym: "tris-L-cysteinyl triiron tetrasulfide" EXACT RESID-name [] synonym: "tris-L-cysteinyl triiron tetrasulfide C3 cluster" EXACT RESID-alternate [] synonym: "tris-L-cysteinyl triiron tetrasulfide cubane form" EXACT RESID-alternate [] synonym: "tris-L-cysteinyl triiron tetrasulfide cuboid cluster" EXACT RESID-alternate [] synonym: "tris-L-cysteinyl triiron tetrasulfide trigonal cluster" EXACT RESID-alternate [] xref: DiffAvg: "292.75" xref: DiffFormula: "C 0 Fe 3 H -3 N 0 O 0 S 4" xref: DiffMono: "292.671267" xref: FormalCharge: "3-" xref: Formula: "C 9 Fe 3 H 12 N 3 O 3 S 7" xref: MassAvg: "602.17" xref: MassMono: "601.698821" xref: Origin: "C, C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00149 name: tetrakis-L-cysteinyl tetrairon tetrasulfide def: "A protein modification that effectively converts four L-cysteine residues and a four-iron four-sulfur cluster to tetrakis-L-cysteinyl tetrairon tetrasulfide." [PubMed:3351918, PubMed:7803404, PubMed:7819196, PubMed:932007, RESID:AA0140] comment: Cross-link 4. synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] synonym: "METAL Iron-sulfur (4Fe-4S); shared with dimeric partner" EXACT UniProt-feature [] synonym: "tetra-mu3-sulfido-tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-tetrahedro-tetrairon" EXACT RESID-systematic [] synonym: "tetra-mu3-sulfidotetrakis(S-cysteinyliron)" EXACT RESID-alternate [] synonym: "tetrakis-L-cysteinyl tetrairon tetrasulfide" EXACT RESID-name [] xref: DiffAvg: "347.59" xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" xref: DiffMono: "347.597831" xref: FormalCharge: "2-" xref: Formula: "C 12 Fe 4 H 16 N 4 O 4 S 8" xref: MassAvg: "760.15" xref: MassMono: "759.634570" xref: Origin: "C, C, C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00150 name: L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-molybdenum seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide." [PubMed:10525412, PubMed:12215645, PubMed:12733878, PubMed:1529354, PubMed:8027059, RESID:AA0141] comment: Cross-link 2; incidental to RESID:AA0300. synonym: "cysteinato-8kappaS-histidino-1kappaN(tau)-[(2R)-4-carboxy-2-(carboxymethyl)-2-oxidobutanoate-1kappaO(1),1kappaO(2)]-mu6-carbido-2:3:4:5:6:7kappa(6)C-hexa-mu3-sulfido-1:2:3kappa(3)S;1:2:4kappa(3)S;1:3:4kappa(3)S;5:6:8kappa(3)S;5:7:8kappa(3)S;6:7:8kappa(3)S-tri-mu2-sulfido-2:5kappa(2)S;3:6kappa(2)S;4:7kappa(2)S molybdenum heptairon" EXACT RESID-systematic [] synonym: "L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide carbide" EXACT RESID-name [] synonym: "nitrogenase iron-molybdenum cofactor" EXACT RESID-alternate [] xref: DiffAvg: "991.53" xref: DiffFormula: "C 7 Fe 7 H 6 Mo 1 N 1 O 7 S 9" xref: DiffMono: "993.213036" xref: Formula: "C 16 Fe 7 H 18 Mo 1 N 5 O 9 S 10" xref: MassAvg: "1231.81" xref: MassMono: "1233.281133" xref: Origin: "C, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00743 ! molybdenum containing modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00151 name: L-cysteinyl molybdopterin def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdopterin." [PubMed:14527393, PubMed:7878465, PubMed:9428520, RESID:AA0142, UniMod:391#C] subset: PSI-MOD-slim synonym: "(4R,5aR,11aR)-8-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-4,5a,6,9,10,11,11a-heptahydro-4-(phosphoric acid)methyl-2,2,10-trioxo-pteridino[6,7-5,6]pyrano[3,4-4,3][1,2,5]molybdadithiolene" EXACT RESID-systematic [] synonym: "cysteinyl Mo-molybdopterin" EXACT RESID-alternate [] synonym: "cysteinyl Mo-pterin" EXACT RESID-alternate [] synonym: "L-cysteinyl molybdopterin" EXACT RESID-name [] synonym: "METAL Molybdenum-pterin" EXACT UniProt-feature [] synonym: "molybdoenzyme molybdenum cofactor" EXACT RESID-alternate [] synonym: "Molybdopterin" RELATED PSI-MS-label [] synonym: "molybdopterin" RELATED UniMod-description [] synonym: "MoPterCys" EXACT PSI-MOD-label [] xref: DiffAvg: "520.27" xref: DiffFormula: "C 10 H 11 Mo 1 N 5 O 8 P 1 S 2" xref: DiffMono: "521.884074" xref: Formula: "C 13 H 16 Mo 1 N 6 O 9 P 1 S 3" xref: MassAvg: "623.41" xref: MassMono: "624.893259" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00744 ! molybdenum pterin containing modification is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00152 name: S-(8alpha-FAD)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S'-(8alpha-FAD)-L-cystine." [PubMed:10220347, RESID:AA0143, UniMod:50#C] subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "8alpha-(S-cysteinyl)FAD" EXACT RESID-alternate [] synonym: "FAD" RELATED PSI-MS-label [] synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] synonym: "MOD_RES S-8alpha-FAD cysteine" EXACT UniProt-feature [] synonym: "S-(8alpha-FAD)-L-cysteine" EXACT RESID-name [] synonym: "S8aFADCys" EXACT PSI-MOD-label [] xref: DiffAvg: "783.54" xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2 S 0" xref: DiffMono: "783.141485" xref: Formula: "C 30 H 36 N 10 O 16 P 2 S 1" xref: MassAvg: "886.68" xref: MassMono: "886.150669" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00895 ! FAD modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00153 name: 3'-(8alpha-FAD)-L-histidine def: "A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FAD)-L-histidine." [PubMed:241294, PubMed:8076, RESID:AA0144, UniMod:50#H] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "3'-(8alpha-FAD)-L-histidine" EXACT RESID-name [] synonym: "8alpha-(N(delta)-histidyl)FAD" EXACT RESID-alternate [] synonym: "8alpha-(N3'-histidyl)FAD" EXACT RESID-alternate [] synonym: "8alpha-N1-histidyl FAD" RELATED RESID-misnomer [] synonym: "FAD" RELATED PSI-MS-label [] synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] synonym: "MOD_RES Pros-8alpha-FAD histidine" EXACT UniProt-feature [] synonym: "N(pi)-(8alpha-FAD)-histidine" EXACT RESID-alternate [] synonym: "Np8aFADHis" EXACT PSI-MOD-label [] synonym: "pros-(8alpha-FAD)-histidine" EXACT RESID-alternate [] xref: DiffAvg: "783.54" xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2" xref: DiffMono: "783.141485" xref: Formula: "C 33 H 38 N 12 O 16 P 2" xref: MassAvg: "920.68" xref: MassMono: "920.200396" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00895 ! FAD modified residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00154 name: O4'-(8alpha-FAD)-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to O4'-(8alpha-FAD)-L-tyrosine." [DeltaMass:0, PubMed:7391034, RESID:AA0145, UniMod:50#Y] comment: From DeltaMass: Average Mass: 783 subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "8alpha-(O4'-tyrosyl)FAD" EXACT RESID-alternate [] synonym: "FAD" RELATED PSI-MS-label [] synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] synonym: "MOD_RES O-8alpha-FAD tyrosine" EXACT UniProt-feature [] synonym: "O-8 alpha-Flavin [FAD])- (of Tyrosine)" EXACT DeltaMass-label [] synonym: "O4'-(8alpha-FAD)-L-tyrosine" EXACT RESID-name [] synonym: "O8aFADTyr" EXACT PSI-MOD-label [] xref: DiffAvg: "783.54" xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2" xref: DiffMono: "783.141485" xref: Formula: "C 36 H 40 N 10 O 17 P 2" xref: MassAvg: "946.72" xref: MassMono: "946.204813" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00895 ! FAD modified residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00155 name: 3'-hydroxylation of L-tyrosine to L-3',4'-dihydroxyphenylalanine def: "A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine." [DeltaMass:0, OMSSA:194, OMSSA:64, PubMed:1610822, PubMed:1903612, PubMed:3734192, RESID:AA0146, UniMod:35#Y] comment: incidental to RESID:AA0368 From DeltaMass: Average Mass: 16 subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA)" EXACT DeltaMass-label [] synonym: "3HyTyr" EXACT PSI-MOD-label [] synonym: "hydroxylationy" EXACT OMSSA-label [] synonym: "L-3',4'-dihydroxyphenylalanine" EXACT RESID-name [] synonym: "L-3'-hydroxytyrosine" EXACT RESID-alternate [] synonym: "L-DOPA" EXACT RESID-alternate [] synonym: "levodopa" EXACT RESID-alternate [] synonym: "mod194" EXACT OMSSA-label [] synonym: "MOD_RES 3',4'-dihydroxyphenylalanine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 9 H 9 N 1 O 3" xref: MassAvg: "179.18" xref: MassMono: "179.058243" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00707 ! hydroxylated tyrosine [Term] id: MOD:00156 name: oxidation of tyrosine to L-2',4',5'-topaquinone def: "A protein modification that effectively converts an L-tyrosine residue to an L-2',4',5'-topaquinone." [ChEBI:21187, PubMed:10387067, PubMed:1457410, PubMed:1569055, PubMed:2111581, RESID:AA0147, UniMod:392#Y] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(5-hydroxy-2,5-cyclohexadien-1,4-dion-2-yl)propanoic acid" EXACT RESID-systematic [] synonym: "2,4,5-trihydroxyphenylalanine quinone" EXACT RESID-alternate [] synonym: "5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone" EXACT RESID-alternate [] synonym: "L-2',4',5'-topaquinone" EXACT RESID-name [] synonym: "L-2,4,5-TOPAquinone" EXACT RESID-alternate [] synonym: "MOD_RES 2',4',5'-topaquinone" EXACT UniProt-feature [] synonym: "Quinone" RELATED PSI-MS-label [] synonym: "quinone" RELATED UniMod-description [] synonym: "TopaQ" EXACT PSI-MOD-label [] synonym: "TPQ" EXACT RESID-alternate [] xref: DiffAvg: "29.98" xref: DiffFormula: "C 0 H -2 N 0 O 2" xref: DiffMono: "29.974179" xref: Formula: "C 9 H 7 N 1 O 4" xref: MassAvg: "193.16" xref: MassMono: "193.037508" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00157 name: oxidation of tryptophan to L-tryptophyl quinone def: "A protein modification that effectively converts an L-tryptophan residue to an L-tryptophan quinone." [DeltaMass:0, PubMed:2028257, RESID:AA0148, UniMod:392#W] comment: incidental to RESID:AA0149; incidental to RESID:AA0313; From DeltaMass: Average Mass: 30. subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(6,7-dioxo-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(6,7-dioxo-6,7-dihydro-1H-indol-3-yl)-propionic acid" EXACT RESID-alternate [] synonym: "3-[(2S)-2-amino-2-carboxyethyl]-6,7-indolinedione" EXACT RESID-alternate [] synonym: "6,7 Dione (from Tryptophan)" EXACT DeltaMass-label [] synonym: "L-tryptophyl quinone" EXACT RESID-name [] synonym: "MOD_RES Tryptophylquinone" EXACT UniProt-feature [] synonym: "N-(3-carboxy-1-oxopropyl)-L-tryptophan" EXACT RESID-alternate [] synonym: "Quinone" RELATED PSI-MS-label [] synonym: "quinone" RELATED UniMod-description [] synonym: "TrpQ" EXACT PSI-MOD-label [] xref: DiffAvg: "29.98" xref: DiffFormula: "C 0 H -2 N 0 O 2" xref: DiffMono: "29.974179" xref: Formula: "C 11 H 8 N 2 O 3" xref: MassAvg: "216.20" xref: MassMono: "216.053492" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00158 name: 4'-(L-tryptophan)-L-tryptophyl quinone def: "A protein modification that effectively cross-links two L-tryptophan residues by a carbon-carbon bond to form 4'-(L-tryptophan)-L-tryptophyl quinone." [ChEBI:20251, DeltaMass:0, PubMed:2028257, RESID:AA0149] comment: Cross-link 2; secondary to RESID:AA0148; From DeltaMass: Average Mass: 28. subset: PSI-MOD-slim synonym: "2,4-BisTrp-6,7-dione (from Tryptophan)" EXACT DeltaMass-label [] synonym: "2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate [] synonym: "3-[(2S)-2-amino-2-carboxyethyl]-4-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-6,7-indolinedione" EXACT RESID-systematic [] synonym: "4'-tryptophan-tryptophylquinone" EXACT RESID-alternate [] synonym: "4-(2'-tryptophyl)tryptophan-6,7-dione" EXACT RESID-alternate [] synonym: "4-(L-tryptophan-2-yl)-L-tryptophyl quinone" EXACT RESID-name [] synonym: "alpha,alpha'-diamino-6',7'-dihydro-6',7'-dioxo-(2,4'-bi-1H-indole)-3,3'-dipropanoic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Tryptophan tryptophylquinone (Trp-Trp)" EXACT UniProt-feature [] synonym: "TTQ" EXACT RESID-alternate [] synonym: "XLNK-4'Trp-TrpQ" EXACT PSI-MOD-label [] xref: DiffAvg: "27.97" xref: DiffFormula: "C 0 H -4 N 0 O 2" xref: DiffMono: "27.958529" xref: Formula: "C 22 H 16 N 4 O 4" xref: MassAvg: "400.39" xref: MassMono: "400.117155" xref: Origin: "W, W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00159 name: O-phosphopantetheine-L-serine def: "A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine." [DeltaMass:0, PubMed:10320345, PubMed:10997907, PubMed:12057197, PubMed:12869567, PubMed:4568609, RESID:AA0150, UniMod:49#S] comment: UniMod has DiffFormula C 11 H 20 N 2 O 6 P 1 S 1 From DeltaMass: Average Mass: 339 subset: PSI-MOD-slim synonym: "(2R)-2-hydroxy-3,3-dimethyl-4-[(2S)-2-amino-2-carboxyethyl]phosphonato-N-(3-oxo-3-[(2-sulfanylethyl)amino]propyl)butanamide" EXACT RESID-systematic [] synonym: "4'-Phosphopantetheine" EXACT DeltaMass-label [] synonym: "MOD_RES O-(pantetheine 4'-phosphoryl)serine" EXACT UniProt-feature [] synonym: "O-phosphopantetheine-L-serine" EXACT RESID-name [] synonym: "OPpantSer" EXACT PSI-MOD-label [] synonym: "Phosphopantetheine" RELATED PSI-MS-label [] synonym: "Phosphopantetheine" RELATED UniMod-description [] xref: DiffAvg: "340.33" xref: DiffFormula: "C 11 H 21 N 2 O 6 P 1 S 1" xref: DiffMono: "340.085794" xref: Formula: "C 14 H 26 N 3 O 8 P 1 S 1" xref: MassAvg: "427.41" xref: MassMono: "427.117822" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00160 name: N4-glycosyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine." [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var] subset: PSI-MOD-slim synonym: "N4GlycoAsn" EXACT PSI-MOD-label [] xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00006 ! N-glycosylated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00161 name: S-glucosyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine." [PubMed:1145128, PubMed:15279557, PubMed:5286858, RESID:AA0152, UniMod:41#C] synonym: "(2R)-2-amino-3-[(beta-D-glucopyranosyl)sulfanyl]propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD S-linked (Glc)" EXACT UniProt-feature [] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] synonym: "S-(beta-D-glucopyranosyl)cysteine" EXACT RESID-alternate [] synonym: "S-glucosyl-L-cysteine" EXACT RESID-name [] synonym: "S-glycosyl-cysteine" EXACT RESID-alternate [] synonym: "SGlcCys" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5 S 0" xref: DiffMono: "162.052823" xref: Formula: "C 9 H 15 N 1 O 6 S 1" xref: MassAvg: "265.28" xref: MassMono: "265.062008" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00426 ! S-glycosylated residue is_a: MOD:00433 ! glucosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00162 name: O5-glucosylgalactosyl-L-hydroxylysine def: "A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine." [PubMed:15149698, PubMed:4288358, PubMed:4319110, RESID:AA0153, UniMod:393] comment: Secondary to RESID:AA0028. subset: PSI-MOD-slim synonym: "(2S,5R)-2,6-diamino-5-[2-O-(alpha-D-glucopyranosyl)-beta-D-galactopyranosyloxy]hexanoic acid" EXACT RESID-systematic [] synonym: "5-(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy-L-lysine" EXACT RESID-alternate [] synonym: "Glucosylgalactosyl" RELATED PSI-MS-label [] synonym: "glucosylgalactosyl hydroxylysine" RELATED UniMod-description [] synonym: "O5-glucosylgalactosyl-L-hydroxylysine" EXACT RESID-name [] synonym: "OGlcGal5HyLys" EXACT PSI-MOD-label [] xref: DiffAvg: "340.28" xref: DiffFormula: "C 12 H 20 N 0 O 11" xref: DiffMono: "340.100561" xref: Formula: "C 18 H 32 N 2 O 12" xref: MassAvg: "468.46" xref: MassMono: "468.195524" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00037 ! 5-hydroxy-L-lysine is_a: MOD:00396 ! O-glycosylated residue is_a: MOD:00476 ! galactosylated residue is_a: MOD:00726 ! glucosylated [Term] id: MOD:00163 name: O-(N-acetylamino)galactosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine." [PubMed:115869, PubMed:16005634, PubMed:3086323, PubMed:8948436, PubMed:9092502, RESID:AA0154] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (GalNAc)" EXACT UniProt-feature [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "mucin type O-glycosylserine" EXACT RESID-alternate [] synonym: "O-(N-acetylamino)galactosyl-L-serine" EXACT RESID-name [] synonym: "O3-(N-acetylgalactosaminyl)serine" EXACT RESID-alternate [] synonym: "OGalNAcSer" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 11 H 18 N 2 O 7" xref: MassAvg: "290.27" xref: MassMono: "290.111401" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00563 ! N-acetylaminogalactosylated residue is_a: MOD:01675 ! O-(N-acetylamino)hexosyl-L-serine [Term] id: MOD:00164 name: O-(N-acetylamino)galactosyl-L-threonine def: "A protein modification that effectively converts an L-asparagine residue to O-(N-acetylaminogalactosyl)-L-threonine." [PubMed:16005634, PubMed:1997327, PubMed:3086323, PubMed:8948436, PubMed:9092502, RESID:AA0155] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (GalNAc)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "mucin type O-glycosylthreonine" EXACT RESID-alternate [] synonym: "O-(N-acetylamino)galactosyl-L-threonine" EXACT RESID-name [] synonym: "O3-(N-acetylgalactosaminyl)threonine" EXACT RESID-alternate [] synonym: "OGalNAcThr" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 12 H 20 N 2 O 7" xref: MassAvg: "304.30" xref: MassMono: "304.127051" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00563 ! N-acetylaminogalactosylated residue is_a: MOD:01676 ! O-(N-acetylamino)hexosyl-L-threonine [Term] id: MOD:00165 name: 1'-mannosyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan." [PubMed:1482345, PubMed:16150691, RESID:AA0156] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "1'-glycosyl-L-tryptophan" EXACT RESID-alternate [] synonym: "1'-mannosyl-L-tryptophan" EXACT RESID-name [] synonym: "CARBOHYD N-linked (Man)" EXACT UniProt-feature [] synonym: "N-mannosyl-tryptophan" EXACT RESID-alternate [] synonym: "N1'ManTrp" EXACT PSI-MOD-label [] synonym: "N1-mannosyl-tryptophan" EXACT RESID-alternate [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 17 H 20 N 2 O 6" xref: MassAvg: "348.36" xref: MassMono: "348.132136" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00006 ! N-glycosylated residue is_a: MOD:00595 ! mannosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00166 name: O4'-glucosyl-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to O4'-glucosyl-tyrosine." [PubMed:15279557, PubMed:3181138, RESID:AA0157, UniMod:41#Y] synonym: "(2S)-2-amino-3-(4-alpha-D-glucopyranosyloxy)phenylpropanoic acid" EXACT RESID-systematic [] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] synonym: "O4'-glucosyl-L-tyrosine" EXACT RESID-name [] synonym: "O4'-glycosyl-L-tyrosine" EXACT RESID-alternate [] synonym: "O4GlcTyr" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 15 H 19 N 1 O 7" xref: MassAvg: "325.32" xref: MassMono: "325.116152" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00433 ! glucosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:01927 ! O-glycosyl-L-tyrosine [Term] id: MOD:00167 name: N-asparaginyl-glycosylphosphatidylinositolethanolamine def: "A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine." [PubMed:1824714, PubMed:8276756, RESID:AA0158] synonym: "GPIAsn" EXACT PSI-MOD-label [] synonym: "LIPID GPI-anchor amidated asparagine" EXACT UniProt-feature [] synonym: "N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 6 H 13 N 3 O 6 P 1" xref: MassAvg: "254.16" xref: MassMono: "254.054197" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00818 ! glycosylphosphatidylinositolated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00168 name: N-aspartyl-glycosylphosphatidylinositolethanolamine def: "A protein modification that effectively converts an L-aspartic acid residue to N-(aspart-1-yl)-glycosylphosphatidylinositolethanolamine." [PubMed:7120400, RESID:AA0159] synonym: "GPIAsp" EXACT PSI-MOD-label [] synonym: "LIPID GPI-anchor amidated aspartate" EXACT UniProt-feature [] synonym: "N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 6 H 12 N 2 O 7 P 1" xref: MassAvg: "255.14" xref: MassMono: "255.038212" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00818 ! glycosylphosphatidylinositolated residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:00169 name: N-cysteinyl-glycosylphosphatidylinositolethanolamine def: "A protein modification that effectively converts an L-cysteine residue to N-cysteinyl-glycosylphosphatidylinositolethanolamine." [PubMed:2897081, RESID:AA0160] synonym: "GPICys" EXACT PSI-MOD-label [] synonym: "LIPID GPI-anchor amidated cysteine" EXACT UniProt-feature [] synonym: "N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1 S 0" xref: DiffMono: "123.008530" xref: Formula: "C 5 H 12 N 2 O 5 P 1 S 1" xref: MassAvg: "243.19" xref: MassMono: "243.020454" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00818 ! glycosylphosphatidylinositolated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00170 name: N-glycyl-glycosylphosphatidylinositolethanolamine def: "A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine." [PubMed:2341397, RESID:AA0161] synonym: "GPIGly" EXACT PSI-MOD-label [] synonym: "LIPID GPI-anchor amidated glycine" EXACT UniProt-feature [] synonym: "N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 4 H 10 N 2 O 5 P 1" xref: MassAvg: "197.11" xref: MassMono: "197.032733" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00818 ! glycosylphosphatidylinositolated residue is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:00171 name: N-seryl-glycosylphosphatidylinositolethanolamine def: "A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine." [PubMed:2111324, PubMed:8448158, RESID:AA0162] synonym: "GPISer" EXACT PSI-MOD-label [] synonym: "LIPID GPI-anchor amidated serine" EXACT UniProt-feature [] synonym: "N-seryl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 5 H 12 N 2 O 6 P 1" xref: MassAvg: "227.13" xref: MassMono: "227.043298" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00818 ! glycosylphosphatidylinositolated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00172 name: N-alanyl-glycosylphosphatidylinositolethanolamine def: "A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine." [PubMed:7682556, PubMed:7744038, RESID:AA0163] synonym: "GPIAla" EXACT PSI-MOD-label [] synonym: "LIPID GPI-anchor amidated alanine" EXACT UniProt-feature [] synonym: "N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 5 H 12 N 2 O 5 P 1" xref: MassAvg: "211.13" xref: MassMono: "211.048383" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00818 ! glycosylphosphatidylinositolated residue is_a: MOD:00901 ! modified L-alanine residue [Term] id: MOD:00173 name: N-threonyl-glycosylphosphatidylinositolethanolamine def: "A protein modification that effectively converts an L-threonine residue to N-threonyl-glycosylphosphatidylinositolethanolamine." [RESID:AA0164] synonym: "GPIThr" EXACT PSI-MOD-label [] synonym: "LIPID GPI-anchor amidated threonine" EXACT UniProt-feature [] synonym: "N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 6 H 14 N 2 O 6 P 1" xref: MassAvg: "241.16" xref: MassMono: "241.058948" xref: Origin: "T" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00818 ! glycosylphosphatidylinositolated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00174 name: N-glycyl-glycosylsphingolipidinositolethanolamine def: "A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, PubMed:8404891, RESID:AA0165] synonym: "GSIGly" EXACT PSI-MOD-label [] synonym: "LIPID GPI-like-anchor amidated glycine" EXACT UniProt-feature [] synonym: "N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 4 H 10 N 2 O 5 P 1" xref: MassAvg: "197.11" xref: MassMono: "197.032733" xref: Origin: "G" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00466 ! glycosylsphingolipidinositolated residue is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:00175 name: N-seryl-glycosylsphingolipidinositolethanolamine def: "A protein modification that effectively converts an L-serine residue to N-seryl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, PubMed:2721485, PubMed:8269952, RESID:AA0166] synonym: "GSISer" EXACT PSI-MOD-label [] synonym: "LIPID GPI-like-anchor amidated serine" EXACT UniProt-feature [] synonym: "N-seryl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 5 H 12 N 2 O 6 P 1" xref: MassAvg: "227.13" xref: MassMono: "227.043298" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00466 ! glycosylsphingolipidinositolated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00176 name: O-(phosphoribosyl dephospho-coenzyme A)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [PubMed:10924139, PubMed:11052675, PubMed:179809, PubMed:180526, PubMed:368065, RESID:AA0167, UniMod:395#S] comment: pRibodePcoA subset: PSI-MOD-slim synonym: "MOD_RES O-(phosphoribosyl dephospho-coenzyme A)serine" EXACT UniProt-feature [] synonym: "O-(phosphoribosyl dephospho-coenzyme A)-L-serine" EXACT RESID-name [] synonym: "O3-(phosphate-5-ribosyl-alpha-2-adenosine-5-diphosphate pantetheine)-L-serine" EXACT RESID-alternate [] synonym: "O3-(phosphoribosyl dephospho-coenzyme A)-L-serine" EXACT RESID-alternate [] synonym: "O3-2'-(5''-phosphoribosyl-3'-dephosphocoenzyme A)-L-serine" EXACT RESID-alternate [] synonym: "OPRibdPCoASer" EXACT PSI-MOD-label [] synonym: "phosphoribosyl dephospho-coenzyme A" RELATED UniMod-description [] synonym: "PhosphoribosyldephosphoCoA" RELATED PSI-MS-label [] xref: DiffAvg: "881.63" xref: DiffFormula: "C 26 H 42 N 7 O 19 P 3 S 1" xref: DiffMono: "881.146903" xref: Formula: "C 29 H 47 N 8 O 21 P 3 S 1" xref: MassAvg: "968.71" xref: MassMono: "968.178931" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00860 ! sulfur containing modified residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00177 name: omega-N-(ADP-ribosyl)-L-arginine def: "A protein modification that effectively converts an L-argininine residue to omega-N-(ADP-ribosyl)-L-arginine." [DeltaMass:0, PubMed:15842200, PubMed:209022, PubMed:3090031, PubMed:3923473, PubMed:6582062, RESID:AA0168, UniMod:213#R] comment: From DeltaMass: Average Mass: 541. subset: PSI-MOD-slim synonym: "(S)-2-amino-5-([imino([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)methyl]amino)pentanoic acid" EXACT RESID-systematic [] synonym: "ADP Ribose addition" RELATED UniMod-description [] synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] synonym: "ADPRibArg" EXACT PSI-MOD-label [] synonym: "MOD_RES ADP-ribosylarginine" EXACT UniProt-feature [] synonym: "N(omega)-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-arginine" EXACT RESID-alternate [] synonym: "N(omega)-alpha-D-ribofuranosyl-L-arginine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] synonym: "N-(ADP-ribosyl)- (on Arginine)" EXACT DeltaMass-label [] synonym: "omega-N-(ADP-ribosyl)-L-arginine" EXACT RESID-name [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "C 21 H 33 N 9 O 14 P 2" xref: MassAvg: "697.49" xref: MassMono: "697.162220" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00178 name: S-(ADP-ribosyl)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(ADP-ribosyl)-L-cysteine." [DeltaMass:0, PubMed:15842200, PubMed:3863818, RESID:AA0169, UniMod:213#C] comment: From DeltaMass: Average Mass: 541. subset: PSI-MOD-slim synonym: "(R)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "ADP Ribose addition" RELATED UniMod-description [] synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] synonym: "ADPRibCys" EXACT PSI-MOD-label [] synonym: "MOD_RES ADP-ribosylcysteine" EXACT UniProt-feature [] synonym: "S-(ADP-ribosyl)- (on Cysteine)" EXACT DeltaMass-label [] synonym: "S-(ADP-ribosyl)-L-cysteine" EXACT RESID-name [] synonym: "S-alpha-D-ribofuranosyl-L-cysteine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] synonym: "S-L-cysteine alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2 S 0" xref: DiffMono: "541.061109" xref: Formula: "C 18 H 26 N 6 O 14 P 2 S 1" xref: MassAvg: "644.44" xref: MassMono: "644.070294" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00179 name: L-glutamyl 5-glycerylphosphorylethanolamine def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-glycerylphosphorylethanolamine." [PubMed:2511205, PubMed:2569467, PubMed:9662537, RESID:AA0170, UniMod:396#E] comment: glycerylPE subset: PSI-MOD-slim synonym: "(S)-2-amino-5-[2-([([2,3-dihydroxypropyl]oxy)(hydroxy)phosphoryl]oxy)ethyl]amino-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "5-L-glutamyl glycerylphosphorylethanolamine" EXACT RESID-name [] synonym: "5GlyceroPEtAGlu" EXACT PSI-MOD-label [] synonym: "GlycerylPE" RELATED PSI-MS-label [] synonym: "glycerylphosphorylethanolamine" RELATED UniMod-description [] synonym: "L-glutamyl 5-glycerophosphoethanolamine" EXACT RESID-alternate [] synonym: "L-glutamyl 5-glycerophosphorylethanolamine" EXACT RESID-alternate [] synonym: "L-glutamyl 5-glycerylphosphorylethanolamine" EXACT RESID-alternate [] synonym: "MOD_RES 5-glutamyl glycerylphosphorylethanolamine" EXACT UniProt-feature [] xref: DiffAvg: "197.13" xref: DiffFormula: "C 5 H 12 N 1 O 5 P 1" xref: DiffMono: "197.045309" xref: Formula: "C 10 H 19 N 2 O 8 P 1" xref: MassAvg: "326.24" xref: MassMono: "326.087902" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00180 name: S-sulfo-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-sulfo-L-cysteine." [PubMed:12876326, PubMed:14752058, PubMed:643076, RESID:AA0171, UniMod:40#C] synonym: "(2R)-2-amino-3-(sulfosulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(sulfothio)propanoic acid" EXACT RESID-alternate [] synonym: "3-(sulfosulfanyl)-L-alanine" EXACT RESID-alternate [] synonym: "cysteine sulfate thioester" EXACT RESID-alternate [] synonym: "cysteine-S-sulfonic acid" EXACT RESID-alternate [] synonym: "O-Sulfonation" RELATED UniMod-description [] synonym: "S-sulfo-L-cysteine" EXACT RESID-name [] synonym: "S-sulfocysteine" EXACT PSI-MOD-alternate [] synonym: "S-sulfocysteine" EXACT RESID-alternate [] synonym: "SSulfCys" EXACT PSI-MOD-label [] synonym: "Sulfo" RELATED PSI-MS-label [] xref: DiffAvg: "80.06" xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1" xref: DiffMono: "79.956815" xref: Formula: "C 3 H 5 N 1 O 4 S 2" xref: MassAvg: "183.20" xref: MassMono: "182.966000" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00695 ! sulfated residue is_a: MOD:00777 ! residues isobaric at 182.96-182.98 Da is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00181 name: O4'-sulfo-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to O4'-sulfo-L-tyrosine." [DeltaMass:88, OMSSA:114, PubMed:10226369, PubMed:14752058, PubMed:2303439, PubMed:3778455, PubMed:3801003, RESID:AA0172, UniMod:40#Y] comment: From DeltaMass: Average Mass: 80 Average Mass Change:80 PubMed:9624161. subset: PSI-MOD-slim synonym: "(S)-2-amino-3-(4-sulfooxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-sulfate" EXACT RESID-alternate [] synonym: "MOD_RES Sulfotyrosine" EXACT UniProt-feature [] synonym: "O-Sulfonation" RELATED UniMod-description [] synonym: "O4'-sulfo-L-tyrosine" EXACT RESID-name [] synonym: "O4-sulfotyrosine" EXACT RESID-alternate [] synonym: "OSulfTyr" EXACT PSI-MOD-label [] synonym: "sulfationy" EXACT OMSSA-label [] synonym: "Sulfo" RELATED PSI-MS-label [] synonym: "Sulphation (of O of Tyrosine)" EXACT DeltaMass-label [] synonym: "tyrosine sulfate" EXACT RESID-alternate [] synonym: "tyrosine-O-sulfonic acid" EXACT RESID-alternate [] synonym: "tyrosine-O-sulphonic acid" EXACT RESID-alternate [] synonym: "Tyrosinyl Sulphate" EXACT DeltaMass-label [] xref: DiffAvg: "80.06" xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1" xref: DiffMono: "79.956815" xref: Formula: "C 9 H 9 N 1 O 5 S 1" xref: MassAvg: "243.23" xref: MassMono: "243.020143" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00695 ! sulfated residue is_a: MOD:00774 ! residues isobaric at 243.02-243.03 Da is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00182 name: L-bromohistidine def: "A protein modification that effectively converts an L-histidine residue to L-bromohistidine." [PubMed:2076468, PubMed:9033387, RESID:AA0173, UniMod:340#H] synonym: "Br1His" EXACT PSI-MOD-label [] synonym: "bromination" RELATED UniMod-description [] synonym: "Bromo" RELATED PSI-MS-label [] synonym: "L-bromohistidine" EXACT RESID-name [] synonym: "MOD_RES Bromohistidine" EXACT UniProt-feature [] xref: DiffAvg: "78.90" xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" xref: DiffMono: "77.910512" xref: Formula: "Br 1 C 6 H 6 N 3 O 1" xref: MassAvg: "216.04" xref: MassMono: "214.969424" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01049 ! halogenated histidine is_a: MOD:01912 ! monobrominated residue [Term] id: MOD:00183 name: L-2'-bromophenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to L-2'-bromophenylalanine." [DeltaMass:83, PubMed:2059627, PubMed:2076468, PubMed:9033387, RESID:AA0174] comment: From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa. synonym: "(S)-2-amino-3-(2-bromophenyl)propanoic acid" EXACT RESID-systematic [] synonym: "2'BrPhe" EXACT PSI-MOD-label [] synonym: "bromination" RELATED UniMod-description [] synonym: "Bromo" RELATED PSI-MS-label [] synonym: "L-2'-bromophenylalanine" EXACT RESID-name [] synonym: "L-o-bromination of Phe with 79Br" EXACT DeltaMass-label [] synonym: "o-bromophenylalanine" EXACT RESID-alternate [] synonym: "ortho-bromophenylalanine" EXACT RESID-alternate [] xref: DiffAvg: "78.90" xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" xref: DiffMono: "77.910512" xref: Formula: "Br 1 C 9 H 8 N 1 O 1" xref: MassAvg: "226.07" xref: MassMono: "224.978926" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00972 ! monobrominated L-phenylalanine [Term] id: MOD:00184 name: L-3'-bromophenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to L-3'-bromophenylalanine." [PubMed:2076468, PubMed:9033387, RESID:AA0175] synonym: "(S)-2-amino-3-(3-bromophenyl)propanoic acid" EXACT RESID-systematic [] synonym: "3'BrPhe" EXACT PSI-MOD-label [] synonym: "bromination" RELATED UniMod-description [] synonym: "Bromo" RELATED PSI-MS-label [] synonym: "L-3'-bromophenylalanine" EXACT RESID-name [] synonym: "m-bromophenylalanine" EXACT RESID-alternate [] synonym: "meta-bromophenylalanine" EXACT RESID-alternate [] xref: DiffAvg: "78.90" xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" xref: DiffMono: "77.910512" xref: Formula: "Br 1 C 9 H 8 N 1 O 1" xref: MassAvg: "226.07" xref: MassMono: "224.978926" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00972 ! monobrominated L-phenylalanine [Term] id: MOD:00185 name: L-4'-bromophenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to L-4'-bromophenylalanine." [PubMed:2076468, PubMed:9033387, RESID:AA0176] synonym: "(2S)-2-amino-3-(4-bromophenyl)propanoic acid" EXACT RESID-systematic [] synonym: "4'BrPhe" EXACT PSI-MOD-label [] synonym: "bromination" RELATED UniMod-description [] synonym: "Bromo" RELATED PSI-MS-label [] synonym: "L-4'-bromophenylalanine" EXACT RESID-name [] synonym: "p-bromophenylalanine" EXACT RESID-alternate [] synonym: "para-bromophenylalanine" EXACT RESID-alternate [] xref: DiffAvg: "78.90" xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" xref: DiffMono: "77.910512" xref: Formula: "Br 1 C 9 H 8 N 1 O 1" xref: MassAvg: "226.07" xref: MassMono: "224.978926" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00972 ! monobrominated L-phenylalanine [Term] id: MOD:00186 name: 3',3'',5'-triiodo-L-thyronine def: "A protein modification that effectively substitutes an L-tyrosine residue with 3',3'',5'-triiodo-L-thyronine." [ChEBI:18258, DeltaMass:0, RESID:AA0177, UniMod:397] comment: From DeltaMass: Average Mass: 470. subset: PSI-MOD-slim synonym: "(S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid" EXACT RESID-systematic [] synonym: "3',3'',5'-triiodo-L-thyronine" EXACT RESID-name [] synonym: "3,3',5-triiodo-L-thyronine" EXACT RESID-alternate [] synonym: "3,5,3'-triiodo-L-thyronine" EXACT RESID-alternate [] synonym: "3,5,3'-Triiodothyronine (from Tyrosine)" EXACT DeltaMass-label [] synonym: "4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine" EXACT RESID-alternate [] synonym: "I3Thy" EXACT PSI-MOD-label [] synonym: "liothyronine" EXACT RESID-alternate [] synonym: "MOD_RES Triiodothyronine" EXACT UniProt-feature [] synonym: "O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine" EXACT RESID-alternate [] synonym: "T3" EXACT RESID-alternate [] synonym: "triiodo" RELATED UniMod-description [] synonym: "Triiodothyronine" RELATED PSI-MS-label [] xref: DiffAvg: "469.79" xref: DiffFormula: "C 6 H 1 I 3 N 0 O 1" xref: DiffMono: "469.716158" xref: Formula: "C 15 H 10 I 3 N 1 O 3" xref: MassAvg: "632.96" xref: MassMono: "632.779486" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00502 ! triiodinated residue is_a: MOD:00998 ! iodinated tyrosine [Term] id: MOD:00187 name: L-thyroxine def: "A protein modification that effectively substitutes an L-tyrosine residue with L-thyroxine." [ChEBI:18332, PubMed:6704086, RESID:AA0178, UniMod:398] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid" EXACT RESID-systematic [] synonym: "3',3'',5',5''-tetraiodo-L-thyronine" EXACT RESID-alternate [] synonym: "3,3',5,5'-tetraiodo-L-thyronine" EXACT RESID-alternate [] synonym: "3,5,3',5'-tetraiodo-L-thyronine" EXACT RESID-alternate [] synonym: "4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine" EXACT RESID-alternate [] synonym: "I4Thy" EXACT PSI-MOD-label [] synonym: "L-thyroxine" EXACT RESID-name [] synonym: "MOD_RES Thyroxine" EXACT UniProt-feature [] synonym: "O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine" EXACT RESID-alternate [] synonym: "T4" EXACT RESID-alternate [] synonym: "tetraiodo" RELATED UniMod-description [] synonym: "Thyroxine" RELATED PSI-MS-label [] xref: DiffAvg: "595.68" xref: DiffFormula: "C 6 H 0 I 4 N 0 O 1" xref: DiffMono: "595.612805" xref: Formula: "C 15 H 9 I 4 N 1 O 3" xref: MassAvg: "758.86" xref: MassMono: "758.676134" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00998 ! iodinated tyrosine [Term] id: MOD:00188 name: 6'-bromo-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 6'-bromo-L-tryptophan." [PubMed:12118011, PubMed:9030520, PubMed:9033387, PubMed:9434739, RESID:AA0179, UniMod:340#W] synonym: "(2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "6'-bromo-L-tryptophan" EXACT RESID-name [] synonym: "6'-BrTrp" EXACT PSI-MOD-label [] synonym: "bromination" RELATED UniMod-description [] synonym: "Bromo" RELATED PSI-MS-label [] synonym: "MOD_RES 6'-bromotryptophan" EXACT UniProt-feature [] xref: DiffAvg: "78.90" xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" xref: DiffMono: "77.910512" xref: Formula: "Br 1 C 11 H 9 N 2 O 1" xref: MassAvg: "265.11" xref: MassMono: "263.989825" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01068 ! halogenated tryptophan is_a: MOD:01912 ! monobrominated residue [Term] id: MOD:00189 name: dehydroalanine (Ser) def: "A protein modification that effectively converts an L-serine residue to dehydroalanine." [DeltaMass:0, OMSSA:140, OMSSA:164, OMSSA:96, PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181#SER, UniMod:23#S] subset: PSI-MOD-slim synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] synonym: "anhydroserine" EXACT RESID-alternate [] synonym: "beta-elim-s" EXACT OMSSA-label [] synonym: "Dehydrated" RELATED PSI-MS-label [] synonym: "dehydro" EXACT OMSSA-label [] synonym: "dehydroalanine" EXACT RESID-name [] synonym: "Dha" EXACT RESID-alternate [] synonym: "Dha(Ser)" EXACT PSI-MOD-label [] synonym: "MOD_RES 2,3-didehydroalanine (Ser)" EXACT UniProt-feature [] synonym: "phospholosss" EXACT OMSSA-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 3 H 3 N 1 O 1" xref: MassAvg: "69.06" xref: MassMono: "69.021464" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00416 ! phosphorylation of an hydroxyl amino acid with prompt loss of phosphate is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01168 ! dehydroalanine [Term] id: MOD:00190 name: dehydrobutyrine (Thr) def: "A protein modification that effectively converts an L-threonine residue to dehydrobutyrine." [DeltaMass:0, OMSSA:141, OMSSA:164, OMSSA:97, PubMed:1547888, PubMed:3769923, RESID:AA0182, UniMod:23#T] subset: PSI-MOD-slim synonym: "(2Z)-2-aminobut-2-enoic acid" EXACT RESID-systematic [] synonym: "(Z)-2-amino-2-butenoic acid" EXACT RESID-alternate [] synonym: "(Z)-2-aminobutenoic acid" EXACT RESID-alternate [] synonym: "(Z)-dehydrobutyrine" EXACT RESID-name [] synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate [] synonym: "3-methyldehydroalanine" EXACT RESID-alternate [] synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate [] synonym: "anhydrothreonine" EXACT RESID-alternate [] synonym: "beta-elim-t" EXACT OMSSA-label [] synonym: "Dehydrated" RELATED PSI-MS-label [] synonym: "Dehydrated" RELATED UniMod-interim [] synonym: "Dehydration" RELATED UniMod-description [] synonym: "dehydro" EXACT OMSSA-label [] synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label [] synonym: "Dhb" EXACT RESID-alternate [] synonym: "Dhb(Thr)" EXACT PSI-MOD-label [] synonym: "methyl-dehydroalanine" EXACT RESID-alternate [] synonym: "MOD_RES (Z)-2,3-didehydrobutyrine" EXACT UniProt-feature [] synonym: "phospholosst" EXACT OMSSA-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 4 H 5 N 1 O 1" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00416 ! phosphorylation of an hydroxyl amino acid with prompt loss of phosphate is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01703 ! dehydrobutyrine [Term] id: MOD:00191 name: (Z)-2,3-didehydrotyrosine def: "A protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine." [PubMed:1347277, PubMed:9631087, RESID:AA0183] comment: incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 subset: PSI-MOD-slim synonym: "(2Z)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid" EXACT RESID-systematic [] synonym: "(Z)-2,3-didehydrogenated tyrosine" EXACT PSI-MOD-alternate [] synonym: "(Z)-2,3-didehydrotyrosine" EXACT RESID-name [] synonym: "2-amino-3-oxo-butanoic_acid" RELATED UniMod-description [] synonym: "amino-(para-hydroxybenzylidenyl)acetic acid" EXACT RESID-alternate [] synonym: "cis-dehydrotyrosine" EXACT RESID-alternate [] synonym: "Didehydro" RELATED PSI-MS-label [] synonym: "green fluorescent protein chromophore" EXACT RESID-alternate [] synonym: "MOD_RES (Z)-2,3-didehydrotyrosine" EXACT UniProt-feature [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "red fluorescent protein chromophore" EXACT RESID-alternate [] synonym: "Z-dHTyr" EXACT PSI-MOD-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 9 H 7 N 1 O 2" xref: MassAvg: "161.16" xref: MassMono: "161.047678" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00706 ! dehydrogenated tyrosine [Term] id: MOD:00192 name: L-serine 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine." [ChEBI:21393, PubMed:1347277, PubMed:9631087, RESID:AA0184] comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "(2-[(1R)-1-amino-2-hydroxyethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] synonym: "2-[1-amino-2-hydroxyethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] synonym: "CROSSLNK 5-imidazolinone (Ser-Gly)" EXACT UniProt-feature [] synonym: "green fluorescent protein chromophore" EXACT RESID-alternate [] synonym: "L-serine 5-imidazolinone glycine" EXACT RESID-name [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "seryl-5-imidazolinone glycine" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 5 H 6 N 2 O 2" xref: MassAvg: "126.11" xref: MassMono: "126.042927" xref: Origin: "G, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00193 name: L-3-oxoalanine (Cys) def: "A protein modification that effectively converts an L-cysteine residue to L-oxoalanine." [DeltaMass:350, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9478923, RESID:AA0185#CYS, UniMod:402#C] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate [] synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer [] synonym: "L-3-oxoalanine" EXACT RESID-name [] synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate [] synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate [] synonym: "L-serinesemialdehyde" RELATED RESID-misnomer [] synonym: "MOD_RES 3-oxoalanine (Cys)" EXACT UniProt-feature [] synonym: "Oxala(Cys)" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.08" xref: DiffFormula: "C 0 H -2 N 0 O 1 S -1" xref: DiffMono: "-17.992806" xref: Formula: "C 3 H 3 N 1 O 2" xref: MassAvg: "85.06" xref: MassMono: "85.016378" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01169 ! L-3-oxoalanine [Term] id: MOD:00194 name: lactic acid def: "A protein modification that effectively converts an L-serine residue to an amino-terminal lactic acid." [PubMed:7607233, RESID:AA0186, UniMod:403#S] synonym: "(2R)-2-hydroxypropanoic acid" EXACT RESID-systematic [] synonym: "2-hydroxypropionic acid" EXACT RESID-alternate [] synonym: "alpha-hydroxypropionic acid" EXACT RESID-alternate [] synonym: "Lac(Ser)" EXACT PSI-MOD-label [] synonym: "lactic acid" EXACT RESID-name [] synonym: "lactic acid from N-term Ser" RELATED UniMod-description [] synonym: "MOD_RES Lactic acid" EXACT UniProt-feature [] synonym: "Ser->LacticAcid" RELATED PSI-MS-label [] xref: DiffAvg: "-15.02" xref: DiffFormula: "C 0 H -1 N -1 O 0" xref: DiffMono: "-15.010899" xref: Formula: "C 3 H 5 O 2" xref: MassAvg: "73.07" xref: MassMono: "73.028954" xref: Origin: "S" xref: TermSpec: "N-term" is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00195 name: L-alanine 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine." [PubMed:10220322, RESID:AA0187] comment: Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "(2-[(1S)-1-aminoethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] synonym: "2-[1-aminoethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "4-methylidene-imidazole-5-one active site" EXACT RESID-alternate [] synonym: "alanyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "CROSSLNK 5-imidazolinone (Ala-Gly)" EXACT UniProt-feature [] synonym: "L-alanine 5-imidazolinone glycine" EXACT RESID-name [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "XLNK-1Ala-NGly(Imidazole)" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 5 H 6 N 2 O 1" xref: MassAvg: "110.12" xref: MassMono: "110.048013" xref: Origin: "A, G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00196 name: L-cysteine 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine." [PubMed:1537807, RESID:AA0188] comment: Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "(2-[(1R)-1-amino-2-sulfanylethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] synonym: "2-[1-amino-2-sulfanylethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] synonym: "CROSSLNK 5-imidazolinone (Cys-Gly)" EXACT UniProt-feature [] synonym: "cysteinyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "L-cysteine 5-imidazolinone glycine" EXACT RESID-name [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "XLNK-1Cys-NGly(Imidazole)" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 5 H 6 N 2 O 1 S 1" xref: MassAvg: "142.18" xref: MassMono: "142.020084" xref: Origin: "C, G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00197 name: 2-imino-glutamine 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine." [PubMed:11050230, PubMed:11209050, RESID:AA0189] comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "2,N-didehydroglutaminyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "2-(3-carbamoyl-1-imino-propyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "2-imino-glutamine 5-imidazolinone glycine" EXACT RESID-name [] synonym: "[2-(3-carbamoyl-1-imino-propyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] synonym: "[2-(4-amino-4-oxobutanimidoyl)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-systematic [] synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Gln-Gly)" EXACT UniProt-feature [] synonym: "fluorescent protein FP583 chromophore" EXACT RESID-alternate [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "red fluorescent protein chromophore" EXACT RESID-alternate [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1" xref: DiffMono: "-20.026215" xref: Formula: "C 7 H 7 N 3 O 2" xref: MassAvg: "165.15" xref: MassMono: "165.053826" xref: Origin: "G, Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00198 name: D-alanine (Ala) def: "A protein modification that effectively converts an L-alanine residue to D-alanine." [PubMed:15023056, PubMed:7287302, PubMed:7961627, RESID:AA0191#ALA] synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic [] synonym: "D-Ala(Ala)" EXACT PSI-MOD-label [] synonym: "D-alanine" EXACT RESID-name [] synonym: "MOD_RES D-alanine (Ala)" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 3 H 5 N 1 O 1" xref: MassAvg: "71.08" xref: MassMono: "71.037114" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00570 ! residues isobaric at 71.037114 Da is_a: MOD:00862 ! D-alanine is_a: MOD:00901 ! modified L-alanine residue [Term] id: MOD:00199 name: D-allo-isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to a D-allo-isoleucine." [ChEBI:30007, PubMed:8223491, RESID:AA0192] synonym: "(2R,3S)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate [] synonym: "3-methyl-norvaline" EXACT RESID-alternate [] synonym: "allo-D-isoleucine" EXACT RESID-alternate [] synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate [] synonym: "D-allo-isoleucine" EXACT RESID-name [] synonym: "D-Ile" EXACT PSI-MOD-label [] synonym: "D-threo-isoleucine" EXACT RESID-alternate [] synonym: "MOD_RES D-allo-isoleucine" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 11 N 1 O 1" xref: MassAvg: "113.16" xref: MassMono: "113.084064" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00306 ! residues isobaric at 113.084064 Da is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00910 ! modified L-isoleucine residue [Term] id: MOD:00200 name: D-methionine def: "A protein modification that effectively converts an L-methionine residue to D-methionine." [ChEBI:29984, PubMed:16033333, PubMed:2542051, RESID:AA0193] synonym: "(2R)-2-amino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-amino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] synonym: "2-amino-4-(methylthio)butyric acid" EXACT RESID-alternate [] synonym: "D-Met" EXACT PSI-MOD-label [] synonym: "D-methionine" EXACT RESID-name [] synonym: "MOD_RES D-methionine" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0" xref: DiffMono: "0.000000" xref: Formula: "C 5 H 9 N 1 O 1 S 1" xref: MassAvg: "131.19" xref: MassMono: "131.040485" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00201 name: D-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to D-phenylalanine." [ChEBI:29996, PubMed:1548227, PubMed:1644179, PubMed:2597281, RESID:AA0194] synonym: "(R)-2-amino-3-phenylpropanoic acid" EXACT RESID-systematic [] synonym: "D-Phe" EXACT PSI-MOD-label [] synonym: "D-phenylalanine" EXACT RESID-name [] synonym: "MOD_RES D-phenylalanine" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 9 H 9 N 1 O 1" xref: MassAvg: "147.18" xref: MassMono: "147.068414" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:00202 name: D-serine (Ser) def: "A protein modification that effectively converts an L-serine residue to D-serine." [PubMed:7973665, RESID:AA0195#SER] synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic [] synonym: "D-Ser(Ser)" EXACT PSI-MOD-label [] synonym: "D-serine" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 3 H 5 N 1 O 2" xref: MassAvg: "87.08" xref: MassMono: "87.032028" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00891 ! D-serine is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00203 name: D-asparagine def: "A protein modification that effectively converts an L-asparagine residue to D-asparagine." [ChEBI:29957, PubMed:1859408, RESID:AA0196] synonym: "(R)-2-amino-4-butanediamic acid" EXACT RESID-systematic [] synonym: "D-alpha-aminosuccinamic acid" EXACT RESID-alternate [] synonym: "D-Asn" EXACT PSI-MOD-label [] synonym: "D-asparagine" EXACT RESID-name [] synonym: "D-aspartic acid beta-amide" EXACT RESID-alternate [] synonym: "MOD_RES D-asparagine" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 4 H 6 N 2 O 2" xref: MassAvg: "114.10" xref: MassMono: "114.042927" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00204 name: D-leucine def: "A protein modification that effectively converts an L-leucine residue to D-leucine." [ChEBI:30005, PubMed:10461743, PubMed:12135762, PubMed:1358533, PubMed:1548227, RESID:AA0197] synonym: "(2R)-2-amino-4-methylpentanoic acid" EXACT RESID-systematic [] synonym: "alpha-aminoisocaproic acid" EXACT RESID-alternate [] synonym: "D-Leu" EXACT PSI-MOD-label [] synonym: "D-leucine" EXACT RESID-name [] synonym: "MOD_RES D-leucine" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 11 N 1 O 1" xref: MassAvg: "113.16" xref: MassMono: "113.084064" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00306 ! residues isobaric at 113.084064 Da is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00911 ! modified L-leucine residue [Term] id: MOD:00205 name: D-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to D-tryptophan." [ChEBI:29955, PubMed:8910408, RESID:AA0198] synonym: "(R)-2-amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "alpha-amino-beta-(3-indolyl)propionoic acid" EXACT RESID-alternate [] synonym: "D-Trp" EXACT PSI-MOD-label [] synonym: "D-tryptophan" EXACT RESID-name [] synonym: "MOD_RES D-tryptophan" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 11 H 10 N 2 O 1" xref: MassAvg: "186.21" xref: MassMono: "186.079313" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00206 name: L-isoglutamyl-polyglycine def: "A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine." [ChEBI:21343, PubMed:10074368, PubMed:16368691, PubMed:7992051, RESID:AA0201] synonym: "gamma-glutamylpolyglycine" EXACT RESID-alternate [] synonym: "L-isoglutamyl-polyglycine" EXACT RESID-name [] synonym: "MOD_RES 5-glutamyl polyglycine" EXACT UniProt-feature [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1" xref: DiffMono: "57.021464" xref: Formula: "C 7 H 10 N 2 O 4" xref: MassAvg: "186.17" xref: MassMono: "186.064057" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00207 name: L-isoglutamyl-polyglutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid." [PubMed:10747868, PubMed:1680872, RESID:AA0202] synonym: "gamma-glutamylpolyglutamic acid" EXACT RESID-alternate [] synonym: "L-isoglutamyl-polyglutamic acid" EXACT RESID-name [] xref: DiffAvg: "129.12" xref: DiffFormula: "C 5 H 7 N 1 O 3" xref: DiffMono: "129.042593" xref: Formula: "C 10 H 14 N 2 O 6" xref: MassAvg: "258.23" xref: MassMono: "258.085186" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00674 ! amidated residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00208 name: O4'-(phospho-5'-adenosine)-L-tyrosine def: "A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine." [DeltaMass:0, PubMed:5543675, RESID:AA0203, UniMod:405#Y] comment: From DeltaMass: Average Mass: 329. subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-[4-(5'-adenosine phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] synonym: "5'-adenylic-O-tyrosine" EXACT RESID-alternate [] synonym: "AMP binding site" RELATED UniMod-description [] synonym: "hydrogen 5'-adenylate tyrosine ester" EXACT RESID-alternate [] synonym: "MOD_RES O-AMP-tyrosine" EXACT UniProt-feature [] synonym: "O-5'-Adenosylation ( of Tyrosine)" EXACT DeltaMass-label [] synonym: "O4'-(phospho-5'-adenosine)-L-tyrosine" EXACT RESID-name [] synonym: "O4'-L-tyrosine 5'-adenosine phosphodiester" EXACT RESID-alternate [] synonym: "OAMPTyr" EXACT PSI-MOD-label [] synonym: "Phosphoadenosine" RELATED PSI-MS-label [] xref: DiffAvg: "329.21" xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" xref: DiffMono: "329.052520" xref: Formula: "C 19 H 21 N 6 O 8 P 1" xref: MassAvg: "492.38" xref: MassMono: "492.115848" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01165 ! adenylated residue [Term] id: MOD:00209 name: S-(2-aminovinyl)-D-cysteine (Cys-Ser) def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [PubMed:3181159, PubMed:3769923, RESID:AA0204#SER] comment: Cross-link 2. synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate [] synonym: "CROSSLNK S-(2-aminovinyl)-D-cysteine (Ser-Cys)" EXACT UniProt-feature [] synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name [] synonym: "XLNK-(D)SCys-VinAm" EXACT PSI-MOD-label [] xref: DiffAvg: "-64.04" xref: DiffFormula: "C -1 H -4 N 0 O -3 S 0" xref: DiffMono: "-64.016044" xref: Formula: "C 5 H 7 N 2 O 1 S 1" xref: MassAvg: "143.18" xref: MassMono: "143.027909" xref: Origin: "C, S" xref: TermSpec: "C-term" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01850 ! S-(2-aminovinyl)-D-cysteine [Term] id: MOD:00210 name: L-cysteine sulfenic acid def: "A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid." [DeltaMass:41, OMSSA:193, PubMed:10964927, PubMed:2501303, PubMed:8756456, PubMed:9214307, PubMed:9586994, PubMed:9587003, RESID:AA0205, UniMod:35#C] comment: From DeltaMass: Average Mass: 16 Average Mass Change:16 Notes:Green et al. in J. B. C. 270, 18209-18211 (1995) quote Kim and Raines in Eur. J. Biochem. 224, 109-114 (1994). Kim and Raines using ESI-MS and sulfhydryl group titration found that bovine seminal ribonuclease contains a single oxidized sulfhydryl group, which cannot participate in a disulfide bond. This form of cysteine is called sulfenic acid (-SOH). subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-(hydroxysulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "(2R)-2-amino-3-(oxido-lambda(4)-sulfanyl)propanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-amino-2-carboxyethanesulfenic acid" EXACT RESID-alternate [] synonym: "2-amino-3-sulfinylpropanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "3-sulfenoalanine" EXACT RESID-alternate [] synonym: "ACT_SITE Cysteine sulfenic acid (-SOH) intermediate" EXACT UniProt-feature [] synonym: "CysOH" EXACT PSI-MOD-label [] synonym: "cysteine S-oxide [tautomer]" EXACT RESID-alternate [] synonym: "cysteine sulfoxide [tautomer]" EXACT RESID-alternate [] synonym: "cysteine sulphenic acid" EXACT RESID-alternate [] synonym: "L-cysteine sulfenic acid" EXACT RESID-name [] synonym: "mod193" EXACT OMSSA-label [] synonym: "MOD_RES Cysteine sulfenic acid (-SOH)" EXACT UniProt-feature [] synonym: "Oxidation" RELATED PSI-MS-label [] synonym: "S-hydroxycysteine" EXACT RESID-alternate [] synonym: "S-oxocysteine [tautomer]" EXACT RESID-alternate [] synonym: "S-oxycysteine [tautomer]" EXACT RESID-alternate [] synonym: "Sulfenic Acid (from Cysteine)" EXACT DeltaMass-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" xref: DiffMono: "15.994915" xref: Formula: "C 3 H 5 N 1 O 2 S 1" xref: MassAvg: "119.14" xref: MassMono: "119.004099" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00708 ! sulfur oxygenated L-cysteine is_a: MOD:01854 ! sulfur monooxygenated residue [Term] id: MOD:00211 name: S-(glycyl)-L-cysteine (Cys-Gly) def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine." [ChEBI:22050, PubMed:3306404, RESID:AA0206] comment: Cross-link 2. For the modification of a C-terminal glycine by formation of a thioester bond with free L-cycteine see MOD:01777 [JSG]. subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid" EXACT RESID-systematic [] synonym: "1-(cystein-S-yl)-glycinate" EXACT RESID-alternate [] synonym: "ACT_SITE Glycyl thioester intermediate" EXACT UniProt-feature [] synonym: "glycine cysteine thioester" EXACT RESID-alternate [] synonym: "S-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate [] synonym: "S-(glycyl)-L-cysteine" EXACT RESID-name [] synonym: "XLNK-SCys-1Gly" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 5 H 7 N 2 O 2 S 1" xref: MassAvg: "159.18" xref: MassMono: "159.022823" xref: Origin: "C, G" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00908 ! modified glycine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00212 name: S-4-hydroxycinnamyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-4-hydroxycinnamyl-L-cysteine." [PubMed:7947803, PubMed:7981196, RESID:AA0207, UniMod:407] synonym: "(2R)-2-amino-3-([(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "cinnamate cysteine thioester" EXACT RESID-alternate [] synonym: "Hydroxycinnamyl" RELATED PSI-MS-label [] synonym: "hydroxycinnamyl" RELATED UniMod-description [] synonym: "MOD_RES S-(4-hydroxycinnamyl)cysteine" EXACT UniProt-feature [] synonym: "S-4-hydroxycinnamyl-L-cysteine" EXACT RESID-name [] synonym: "S-para-coumaryl-L-cysteine" EXACT RESID-alternate [] xref: DiffAvg: "146.14" xref: DiffFormula: "C 9 H 6 N 0 O 2 S 0" xref: DiffMono: "146.036779" xref: Formula: "C 12 H 11 N 1 O 3 S 1" xref: MassAvg: "249.28" xref: MassMono: "249.045964" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00213 name: chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine def: "A protein modification that effectively cross-links an L-serine residue to the polymer chondroitin sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:1794445, PubMed:1898736, PubMed:3472204, RESID:AA0208] synonym: "chondroitin 4-sulfate (chondroitin sulfate A)" EXACT RESID-alternate [] synonym: "chondroitin 6-sulfate (chondroitin sulfate C)" EXACT RESID-alternate [] synonym: "chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name [] synonym: "poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine; poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-6-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0" xref: DiffMono: "-1.007825" xref: Formula: "C 3 H 4 N 1 O 2" xref: MassAvg: "86.07" xref: MassMono: "86.024203" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine [Term] id: MOD:00214 name: dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine def: "A protein modification that effectively cross-links an L-serine residue to the polymer dermatan 4-sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:2914936, PubMed:3472204, RESID:AA0209] synonym: "beta-heparin" EXACT RESID-alternate [] synonym: "chondroitin sulfate B" EXACT RESID-alternate [] synonym: "dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name [] synonym: "poly[beta-1,4-L-idopyranuronosyl-alpha-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0" xref: DiffMono: "-1.007825" xref: Formula: "C 3 H 4 N 1 O 2" xref: MassAvg: "86.07" xref: MassMono: "86.024203" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine [Term] id: MOD:00215 name: heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine def: "A protein modification that effectively cross-links an L-serine residue to the polymer heparan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:3472204, RESID:AA0210] synonym: "heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name [] synonym: "heparin" EXACT RESID-alternate [] synonym: "heparitin sulfate" EXACT RESID-alternate [] synonym: "poly[alpha-1,4-(2-sulfate D-glucopyranuronosyl)-beta-1,4-(2-sulfamino-2-deoxy-6-sulfate D-glucosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0" xref: DiffMono: "-1.007825" xref: Formula: "C 3 H 4 N 1 O 2" xref: MassAvg: "86.07" xref: MassMono: "86.024203" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine [Term] id: MOD:00216 name: N6-formyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-formyl-L-lysine." [OMSSA:43, PubMed:15799070, RESID:AA0211, UniMod:122#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(formylamino)hexanoic acid" EXACT RESID-systematic [] synonym: "epsilon-formyllysine" EXACT RESID-alternate [] synonym: "Formyl" RELATED PSI-MS-label [] synonym: "Formylation" RELATED UniMod-description [] synonym: "formylk" EXACT OMSSA-label [] synonym: "MOD_RES N6-formyllysine" EXACT UniProt-feature [] synonym: "N(zeta)-formyllysine" EXACT RESID-alternate [] synonym: "N6-formyl-L-lysine" EXACT RESID-name [] synonym: "N6-formylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "N6FoLys" EXACT PSI-MOD-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 7 H 12 N 2 O 2" xref: MassAvg: "156.19" xref: MassMono: "156.089878" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00409 ! N-formylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:00217 name: O4-arabinosyl-L-hydroxyproline def: "A protein modification that effectively converts an L-proline residue to O4-arabinosyl-L-hydroxyproline." [DeltaMass:0, PubMed:666730, PubMed:7852316, RESID:AA0212, UniMod:408] comment: secondary to RESID:AA0030; From DeltaMass: Average Mass: 147. subset: PSI-MOD-slim synonym: "(2S,4R)-4-(beta-L-arabinofuranosyloxy)pyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "4-(beta-L-arabinofuranosyloxy)proline" EXACT RESID-alternate [] synonym: "4-Glycosyloxy- (pentosyl,C5) (of Proline)" EXACT DeltaMass-label [] synonym: "beta-arabinofuranosyl-4-hydroxyproline" EXACT RESID-alternate [] synonym: "Glycosyl" RELATED PSI-MS-label [] synonym: "glycosyl-L-hydroxyproline" RELATED UniMod-description [] synonym: "O4-arabinosyl-L-hydroxyproline" EXACT RESID-name [] synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate [] synonym: "OAra4HyPro" EXACT PSI-MOD-label [] xref: DiffAvg: "148.11" xref: DiffFormula: "C 5 H 8 N 0 O 5" xref: DiffMono: "148.037173" xref: Formula: "C 10 H 15 N 1 O 6" xref: MassAvg: "245.23" xref: MassMono: "245.089937" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00396 ! O-glycosylated residue is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:00218 name: O-(phospho-5'-RNA)-L-serine def: "A protein modification that effectively crosslinks an L-serine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-serine." [PubMed:1705009, RESID:AA0213] synonym: "(S)-2-amino-3-(5'-ribonucleic acid phosphonoxy)propanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES O-(5'-phospho-RNA)-serine" EXACT UniProt-feature [] synonym: "O-(phospho-5'-RNA)-L-serine" EXACT RESID-name [] synonym: "O3-(phospho-5'-RNA)-L-serine" EXACT RESID-alternate [] synonym: "O3-L-serine 5'-RNA phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "78.97" xref: DiffFormula: "C 0 H 0 N 0 O 3 P 1" xref: DiffMono: "78.958505" xref: Formula: "C 3 H 5 N 1 O 5 P 1" xref: MassAvg: "166.05" xref: MassMono: "165.990534" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00751 ! ribonucleic acid linked residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00219 name: L-citrulline def: "A protein modification that effectively converts an L-arginine residue to L-citrulline." [DeltaMass:0, OMSSA:33, PubMed:2466844, RESID:AA0214, UniMod:7#R] comment: This modification is not the result of deamidation, instead the guanidino group is replaced with an ureido group. subset: PSI-MOD-slim synonym: "(S)-2-amino-5-(carbamoylamino)pentanoic acid" EXACT RESID-systematic [] synonym: "2-amino-5-(aminocarbonyl)aminopentanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-delta-ureidovaleric acid" EXACT RESID-alternate [] synonym: "Cit" EXACT PSI-MOD-label [] synonym: "citrullinationr" EXACT OMSSA-label [] synonym: "Citrulline" EXACT DeltaMass-label [] synonym: "Deamidated" RELATED PSI-MS-label [] synonym: "Deamidated" RELATED UniMod-interim [] synonym: "Deamidation" RELATED UniMod-description [] synonym: "delta-ureidonorvaline" EXACT RESID-alternate [] synonym: "L-citrulline" EXACT RESID-name [] synonym: "MOD_RES Citrulline" EXACT UniProt-feature [] synonym: "N5-(aminocarbonyl)ornithine" EXACT RESID-alternate [] synonym: "N5-carbamoylornithine" EXACT RESID-alternate [] synonym: "N5-carbamylornithine" EXACT RESID-alternate [] xref: DiffAvg: "0.98" xref: DiffFormula: "C 0 H -1 N -1 O 1" xref: DiffMono: "0.984016" xref: Formula: "C 6 H 11 N 3 O 2" xref: MassAvg: "157.17" xref: MassMono: "157.085127" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00220 name: 4-hydroxy-L-arginine def: "A protein modification that effectively converts an L-arginine residue to a 4-hydroxy-L-arginine." [PubMed:10966817, PubMed:7650037, RESID:AA0215] synonym: "(2S,4Xi)-2-amino-5-[(diaminomethylidene)amino]-4-hydroxypentanoic acid" EXACT RESID-systematic [] synonym: "2-amino-5-(carbamimidamido)-4-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-amino-5-[(aminoiminomethyl)amino]-4-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-amino-5-guanidino-4-hydroxypentanoic acid" EXACT RESID-alternate [] synonym: "4-hydroxy-L-arginine" EXACT RESID-name [] synonym: "4-hydroxylated L-arginine" EXACT PSI-MOD-alternate [] synonym: "4HyArg" EXACT PSI-MOD-label [] synonym: "C(gamma)-hydroxyarginine" EXACT RESID-alternate [] synonym: "gamma-hydroxyarginine" EXACT RESID-alternate [] synonym: "MOD_RES 4-hydroxyarginine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 12 N 4 O 2" xref: MassAvg: "172.19" xref: MassMono: "172.096026" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00682 ! hydroxylated arginine [Term] id: MOD:00221 name: N-(L-isoaspartyl)-L-cysteine def: "A protein modification that effectively crosslinks L-aspartic acid and L-cysteine residues via an isopeptide bond to form N-(L-isoaspartyl)-L-cysteine." [PubMed:8286361, RESID:AA0216] comment: Cross-link 2. synonym: "(S)-2-amino-4-((R)-1-carboxy-2-sulfanylethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "2-(3-amino-3-carboxypropanoyl)amino-3-mercaptopropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-N4-(1-carboxy-2-mercaptoethyl)butanediamic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Isoaspartyl cysteine isopeptide (Cys-Asn)" EXACT UniProt-feature [] synonym: "N-(L-isoaspartyl)-L-cysteine" EXACT RESID-name [] synonym: "N-beta-aspartylcysteine" EXACT RESID-alternate [] synonym: "N-isoaspartyl cysteine" EXACT RESID-alternate [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0" xref: DiffMono: "-17.026549" xref: Formula: "C 7 H 9 N 2 O 3 S 1" xref: MassAvg: "201.22" xref: MassMono: "201.033388" xref: Origin: "C, N" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00222 name: 2'-alpha-mannosyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 2'-alpha-mannosyl-L-tryptophan." [PubMed:15279557, PubMed:7547911, PubMed:7947762, RESID:AA0217, UniMod:41#W] synonym: "(2S)-2-amino-3-(2-beta-D-mannopyranosyl-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "2'-mannosyl-L-tryptophan" EXACT RESID-name [] synonym: "2'-tryptophan C-mannoside" EXACT RESID-alternate [] synonym: "C2'ManTrp" EXACT PSI-MOD-label [] synonym: "CARBOHYD C-linked (Man)" EXACT UniProt-feature [] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 17 H 20 N 2 O 6" xref: MassAvg: "348.36" xref: MassMono: "348.132136" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00421 ! C-glycosylated residue is_a: MOD:00595 ! mannosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00223 name: N6-mureinyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-mureinyl-L-lysine." [PubMed:4261992, RESID:AA0218] synonym: "MOD_RES N6-murein peptidoglycan lysine" EXACT UniProt-feature [] synonym: "N6-[(2R,6S)-2-(N-(N-mureinyl-(R)-alanyl)-(S)-glutamyl)amino-6-amino-6-carboxy-1-oxohex-1-yl]lysine" EXACT RESID-alternate [] synonym: "N6-mureinyl-L-lysine" EXACT RESID-name [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0" xref: DiffMono: "-1.007825" xref: Formula: "C 6 H 11 N 2 O 1" xref: MassAvg: "127.17" xref: MassMono: "127.087138" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01159 ! peptidoglycanated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:00224 name: 1-chondroitin sulfate-L-aspartic acid ester def: "A protein modification that effectively converts an L-aspartic acid residue to 1-chondroitin sulfate-L-aspartic acid ester" [PubMed:1898736, RESID:AA0219] synonym: "1-aspartic acid ester with 6-chondroitin 4-sulfate" EXACT RESID-alternate [] synonym: "1-chondroitin sulfate-L-aspartic acid ester" EXACT RESID-name [] synonym: "MOD_RES Aspartate 1-(chondroitin 4-sulfate)-ester" EXACT UniProt-feature [] synonym: "poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-6-(1-L-aspartyl)-D-galactose)" EXACT RESID-alternate [] synonym: "protein-glycosaminoglycan-protein cross-link" EXACT RESID-alternate [] xref: DiffAvg: "441.36" xref: DiffFormula: "C 14 H 19 N 1 O 13 S 1" xref: DiffMono: "441.057711" xref: Formula: "C 18 H 25 N 2 O 17 S 1" xref: MassAvg: "573.45" xref: MassMono: "573.087393" xref: Origin: "D" xref: TermSpec: "C-term" is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:00225 name: S-(6-FMN)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(6-FMN)-L-cysteine." [PubMed:10869173, PubMed:1551870, PubMed:620783, RESID:AA0220, UniMod:409#C] subset: PSI-MOD-slim synonym: "(R)-2-amino-3-[6-riboflavin 5'-dihydrogen phosphate]sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "6-[S-cysteinyl]flavin mononucleotide" EXACT RESID-alternate [] synonym: "6-[S-cysteinyl]FMN" EXACT RESID-alternate [] synonym: "flavin mononucleotide" RELATED UniMod-description [] synonym: "FMNH" RELATED PSI-MS-label [] synonym: "MOD_RES S-6-FMN cysteine" EXACT UniProt-feature [] synonym: "S-(6-FMN)-L-cysteine" EXACT RESID-name [] synonym: "S6FMNCys" EXACT PSI-MOD-label [] xref: DiffAvg: "454.33" xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1 S 0" xref: DiffMono: "454.088965" xref: Formula: "C 20 H 24 N 5 O 10 P 1 S 1" xref: MassAvg: "557.47" xref: MassMono: "557.098150" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00896 ! FMN modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00226 name: 1'-(8alpha-FAD)-L-histidine def: "A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine." [DeltaMass:0, PubMed:10585424, PubMed:1396672, PubMed:4339951, PubMed:9261083, RESID:AA0221, UniMod:50#H] comment: From DeltaMass: Average Mass: 784 subset: PSI-MOD-slim synonym: "(S)-2-amino-3-(1-[8alpha riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "1'-(8alpha-FAD)-L-histidine" EXACT RESID-name [] synonym: "8alpha-(N(epsilon)-histidyl)FAD" EXACT RESID-alternate [] synonym: "8alpha-(N1'-histidyl)FAD" EXACT RESID-alternate [] synonym: "8alpha-N3-histidyl FAD" RELATED RESID-misnomer [] synonym: "FAD" RELATED PSI-MS-label [] synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] synonym: "MOD_RES Tele-8alpha-FAD histidine" EXACT UniProt-feature [] synonym: "N theta and N pi-(8alpha-Flavin) (on Histidine)" EXACT DeltaMass-label [] synonym: "N(tau)-(8alpha-FAD)-histidine" EXACT RESID-alternate [] synonym: "Nt8aFADHis" EXACT PSI-MOD-label [] synonym: "tele-(8alpha-FAD)-histidine" EXACT RESID-alternate [] xref: DiffAvg: "783.54" xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2" xref: DiffMono: "783.141485" xref: Formula: "C 33 H 38 N 12 O 16 P 2" xref: MassAvg: "920.68" xref: MassMono: "920.200396" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00895 ! FAD modified residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00227 name: omega-N-phospho-L-arginine def: "A protein modification that effectively converts an L-arginine residue to omega-N-phospho-L-arginine." [PubMed:8300603, RESID:AA0222, UniMod:21#R] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-([amino(phosphonoamino)methylidene]amino)pentanoic acid" EXACT RESID-systematic [] synonym: "(2S)-2-amino-5-(N'-phosphonocarbamimidamido)pentanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-delta-phosphonoguanidinovaleric acid" EXACT RESID-alternate [] synonym: "MOD_RES Phosphoarginine" EXACT UniProt-feature [] synonym: "N(gamma)-phosphoarginine" EXACT RESID-alternate [] synonym: "N(omega)-phosphono-L-arginine" EXACT RESID-alternate [] synonym: "N5-[imino(phosphonoamino)methyl]-L-ornithine" EXACT RESID-alternate [] synonym: "omega-N-phospho-L-arginine" EXACT RESID-name [] synonym: "PArg" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "phosphoarginine" EXACT RESID-alternate [] synonym: "Phosphorylation" RELATED UniMod-description [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 6 H 13 N 4 O 4 P 1" xref: MassAvg: "236.17" xref: MassMono: "236.067442" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:01456 ! N-phosphorylated residue [Term] id: MOD:00228 name: S-diphytanylglycerol diether-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-diphytanylglycerol diether-L-cysteine." [PubMed:7797461, PubMed:8195126, RESID:AA0223, UniMod:410] comment: incidental to RESID:AA0043. subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-([(2S)-2,3-bis(3,7,11,15-tetramethylhexadecanyloxy)propyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "Archaeol" RELATED PSI-MS-label [] synonym: "LIPID S-archaeol cysteine" EXACT UniProt-feature [] synonym: "S-(diphytanylglyceryl)-L-cysteine" EXACT RESID-name [] synonym: "S-[2',3'-bis(phytanyloxy)propyl]cysteine" EXACT RESID-alternate [] synonym: "S-archaeol cysteine" EXACT RESID-alternate [] synonym: "S-diphytanylglycerol diether" RELATED UniMod-description [] synonym: "SPhyt2GlyceroCys" EXACT PSI-MOD-label [] xref: DiffAvg: "635.16" xref: DiffFormula: "C 43 H 86 N 0 O 2 S 0" xref: DiffMono: "634.662782" xref: Formula: "C 46 H 91 N 1 O 3 S 1" xref: MassAvg: "738.30" xref: MassMono: "737.671967" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00229 name: alpha-1-microglobulin-Ig alpha complex chromophore def: "A protein modification that effectively converts two L-cysteine residues to form alpha-1-microglobulin-Ig alpha complex chromophore." [PubMed:11058759, PubMed:11877257, PubMed:7506257, PubMed:7535251, RESID:AA0224] comment: Cross-link 2. synonym: "alpha-1-microglobulin-Ig alpha complex chromophore" EXACT RESID-name [] synonym: "BINDING Multimeric 3-hydroxykynurenine chromophore (covalent)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 6 H 8 N 2 O 2 S 2" xref: MassAvg: "204.26" xref: MassMono: "204.002720" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00230 name: bis-L-cysteinyl bis-L-histidino diiron disulfide def: "A protein modification that effectively converts two L-cysteine residues, two L-histidine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bis-L-histidino diiron disulfide." [PubMed:2765515, PubMed:9651245, RESID:AA0225] comment: Cross-link 4. synonym: "bis-L-cysteinyl bis-L-histidino diiron disulfide" EXACT RESID-name [] synonym: "di-mu-sulfido(bis-S-cysteinyliron)(bis-N3'-histidinoiron)" EXACT RESID-systematic [] synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] synonym: "METAL Iron-sulfur (2Fe-2S); via pros nitrogen" EXACT UniProt-feature [] synonym: "Rieske iron-sulfur cofactor" EXACT RESID-alternate [] xref: DiffAvg: "171.78" xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2" xref: DiffMono: "171.783814" xref: FormalCharge: "2-" xref: Formula: "C 18 Fe 2 H 20 N 8 O 4 S 4" xref: MassAvg: "652.34" xref: MassMono: "651.920007" xref: Origin: "C, C, H, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00231 name: hexakis-L-cysteinyl hexairon hexasulfide def: "A protein modification that effectively converts six L-cysteine residues and a six-iron six-sulfur cluster to hexakis-L-cysteinyl hexairon hexasulfide." [PubMed:1311311, PubMed:1318833, RESID:AA0226] comment: Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "hexa-mu3-sulfido-hexakis(cysteinato-kappaS)-hexairon" EXACT RESID-systematic [] synonym: "hexa-mu3-sulfido-hexakis(S-cysteinyliron)" EXACT RESID-alternate [] synonym: "hexakis-L-cysteinyl hexairon hexasulfide" EXACT RESID-name [] synonym: "prismane iron-sulfur cofactor" EXACT RESID-alternate [] xref: DiffAvg: "521.38" xref: DiffFormula: "C 0 Fe 6 H -6 N 0 O 0 S 6" xref: DiffMono: "521.395649" xref: FormalCharge: "1-" xref: Formula: "C 18 Fe 6 H 24 N 6 O 6 S 12" xref: MassAvg: "1140.22" xref: MassMono: "1139.450758" xref: Origin: "C, C, C, C, C, C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00232 name: N6-(phospho-5'-adenosine)-L-lysine def: "A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form N6-(phospho-5'-adenosine)-L-lysine." [DeltaMass:316, PubMed:3882425, PubMed:4944632, RESID:AA0227, UniMod:405#K] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(5'-adenosine phosphonamino)hexanoic acid" EXACT RESID-systematic [] synonym: "5'-adenylic-N6-L-lysine" EXACT RESID-alternate [] synonym: "ACT_SITE N6-AMP-lysine intermediate" EXACT UniProt-feature [] synonym: "AMP binding site" RELATED UniMod-description [] synonym: "AMP Lysyl" EXACT DeltaMass-label [] synonym: "epsilon-5'-adenylic-L-lysine" EXACT RESID-alternate [] synonym: "L-lysine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate [] synonym: "N(zeta)-5'-adenylic-L-lysine" EXACT RESID-alternate [] synonym: "N6-(phospho-5'-adenosine)-L-lysine" EXACT RESID-name [] synonym: "N6-L-lysine 5'-adenosine phosphoramidester" EXACT RESID-alternate [] synonym: "N6AMPLys" EXACT PSI-MOD-label [] synonym: "Phosphoadenosine" RELATED PSI-MS-label [] xref: DiffAvg: "329.21" xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" xref: DiffMono: "329.052520" xref: Formula: "C 16 H 24 N 7 O 7 P 1" xref: MassAvg: "457.38" xref: MassMono: "457.147483" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01165 ! adenylated residue [Term] id: MOD:00233 name: N6-(phospho-5'-guanosine)-L-lysine def: "A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoguanosine through a phosphoramide ester bond to form N6-(phospho-5'-guanosine)-L-lysine." [DeltaMass:304, PubMed:6092377, PubMed:6264433, RESID:AA0228, UniMod:413#K] comment: From DeltaMass: Average Mass: 345 Formula:C10H12O5N7P1 Monoisotopic Mass Change:345.047 Average Mass Change:345.209 References:PE Sciex subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(5'-guanosine phosphonamino)hexanoic acid" EXACT RESID-systematic [] synonym: "5'-guanylic-N6-L-lysine" EXACT RESID-alternate [] synonym: "5'phos Guanosyl" EXACT DeltaMass-label [] synonym: "ACT_SITE N6-GMP-lysine intermediate" EXACT UniProt-feature [] synonym: "epsilon-5'-guanylic-L-lysine" EXACT RESID-alternate [] synonym: "L-lysine monoanhydride with 5'-guanylic acid" EXACT RESID-alternate [] synonym: "lysine guanosine-5'-monophosphate" EXACT RESID-alternate [] synonym: "N(zeta)-5'-guanylic-lysine" EXACT RESID-alternate [] synonym: "N6-(5'-guanylyl)-lysine" EXACT RESID-alternate [] synonym: "N6-(phospho-5'-guanosine)-L-lysine" EXACT RESID-name [] synonym: "N6-L-lysine 5'-guanosine phosphoramidester" EXACT RESID-alternate [] synonym: "N6GMPLys" EXACT PSI-MOD-label [] synonym: "phospho-guanosine" RELATED UniMod-description [] synonym: "Phosphoguanosine" RELATED PSI-MS-label [] xref: DiffAvg: "345.21" xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1" xref: DiffMono: "345.047434" xref: Formula: "C 16 H 24 N 7 O 8 P 1" xref: MassAvg: "473.38" xref: MassMono: "473.142397" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01163 ! guanylated residue [Term] id: MOD:00234 name: L-cysteine glutathione disulfide def: "A protein modification that effectively converts an L-cysteine residue to S-glutathionyl-L-cysteine." [ChEBI:21264, DeltaMass:0, OMSSA:51, PubMed:3083866, PubMed:8344916, RESID:AA0229, UniMod:55] comment: From DeltaMass: Average Mass: 305 subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-((2S)-2-((4R)-4-amino-4-carboxyl-1-oxobutyl)amino-3-(carboxylmethyl)amino-3-oxo-propyl)dithio-propanoic acid" EXACT RESID-systematic [] synonym: "cysteinyl glutathione" EXACT RESID-alternate [] synonym: "Glutathionation" EXACT DeltaMass-label [] synonym: "Glutathione" RELATED PSI-MS-label [] synonym: "glutathione disulfide" RELATED UniMod-description [] synonym: "glutathionec" EXACT OMSSA-label [] synonym: "L-cysteine glutathione disulfide" EXACT RESID-name [] synonym: "L-gamma-glutamyl-L-cysteinyl-glycine (2-1')-disulfide with L-cysteine" EXACT RESID-alternate [] synonym: "MOD_RES S-glutathionyl cysteine" EXACT UniProt-feature [] synonym: "N-(N-gamma-glutamyl-cystinyl)-glycine" EXACT RESID-alternate [] synonym: "SGltCys" EXACT PSI-MOD-label [] xref: DiffAvg: "305.30" xref: DiffFormula: "C 10 H 15 N 3 O 6 S 1" xref: DiffMono: "305.068156" xref: Formula: "C 13 H 20 N 4 O 7 S 2" xref: MassAvg: "408.44" xref: MassMono: "408.077341" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01862 ! disulfide conjugated residue [Term] id: MOD:00235 name: S-nitrosyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-nitrosyl-L-cysteine." [PubMed:10442087, PubMed:11562475, PubMed:15688001, PubMed:8626764, PubMed:8637569, RESID:AA0230, UniMod:275] subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-nitrososulfanyl-propanoic acid" EXACT RESID-systematic [] synonym: "L-cysteine nitrite ester" EXACT RESID-alternate [] synonym: "MOD_RES S-nitrosocysteine" EXACT UniProt-feature [] synonym: "Nitrosyl" RELATED PSI-MS-label [] synonym: "S-nitrosocysteine" EXACT RESID-alternate [] synonym: "S-nitrosyl-L-cysteine" EXACT RESID-name [] synonym: "S-nitrosylation" RELATED UniMod-description [] synonym: "SNOCys" EXACT PSI-MOD-label [] xref: DiffAvg: "29.00" xref: DiffFormula: "C 0 H -1 N 1 O 1 S 0" xref: DiffMono: "28.990164" xref: Formula: "C 3 H 4 N 2 O 2 S 1" xref: MassAvg: "132.14" xref: MassMono: "131.999348" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00236 name: N4-(ADP-ribosyl)-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4-(ADP-ribosyl)-L-asparagine." [PubMed:15842200, PubMed:2498316, RESID:AA0231, UniMod:213#N] synonym: "(S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "ADP Ribose addition" RELATED UniMod-description [] synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] synonym: "MOD_RES ADP-ribosylasparagine" EXACT UniProt-feature [] synonym: "N4-(ADP-ribosyl)-L-asparagine" EXACT RESID-name [] synonym: "N4-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-asparagine" EXACT RESID-alternate [] synonym: "N4-alpha-D-ribofuranosyl-L-asparagine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "C 19 H 27 N 7 O 15 P 2" xref: MassAvg: "655.41" xref: MassMono: "655.104036" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00237 name: L-beta-methylthioaspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to L-beta-methylthioaspartic acid." [DeltaMass:61, OMSSA:13, OMSSA:26, PubMed:15473684, PubMed:8844851, RESID:AA0232, UniMod:39#D] subset: PSI-MOD-slim synonym: "(2R,3Xi)-2-amino-3-(methylsulfanyl)butanedioic acid" EXACT RESID-systematic [] synonym: "3-(methylthio)-L-aspartic acid" EXACT RESID-name [] synonym: "3-carboxy-S-methyl-cysteine" EXACT RESID-alternate [] synonym: "3-methylthio-aspartic acid" EXACT RESID-alternate [] synonym: "3MeSAsp" EXACT PSI-MOD-label [] synonym: "beta-Methylthio-aspartic acid" EXACT DeltaMass-label [] synonym: "beta-methylthio-aspartic acid" EXACT RESID-alternate [] synonym: "Beta-methylthiolation" RELATED UniMod-description [] synonym: "bmethylthiold" EXACT OMSSA-label [] synonym: "Methylthio" RELATED UniMod-interim [] synonym: "methythiold" EXACT OMSSA-label [] synonym: "MOD_RES 3-methylthioaspartic acid" EXACT UniProt-feature [] xref: DiffAvg: "46.09" xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1" xref: DiffMono: "45.987721" xref: Formula: "C 5 H 7 N 1 O 3 S 1" xref: MassAvg: "161.18" xref: MassMono: "161.014664" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01153 ! methylthiolated residue [Term] id: MOD:00238 name: 5'-(N6-L-lysine)-L-topaquinone def: "A protein modification that effectively cross-links an L-lysine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 5'-(N6-L-lysine)-L-topaquinone." [PubMed:8688089, RESID:AA0233] comment: Cross-link 2; secondary to RESID:AA0147. synonym: "1-[(S)-5-amino-5-carboxypentyl]amino-2-[(S)-2-amino-2-carboxyethyl]-2,6-cyclohexadien-4,5-dione" EXACT RESID-systematic [] synonym: "2'-(L-lys-N6-yl)-L-4',5'-topaquinone" EXACT RESID-name [] synonym: "2'-(L-lysine)-L-tyrosyl-4',5'-quinone" EXACT RESID-alternate [] synonym: "CROSSLNK Lysine tyrosylquinone (Lys-Tyr)" EXACT UniProt-feature [] synonym: "CROSSLNK Lysine tyrosylquinone (Tyr-Lys)" EXACT UniProt-feature [] synonym: "LTQ" EXACT RESID-alternate [] synonym: "lysyl oxidase cofactor" EXACT RESID-alternate [] xref: DiffAvg: "11.97" xref: DiffFormula: "C 0 H -4 N 0 O 1" xref: DiffMono: "11.963614" xref: Formula: "C 15 H 17 N 3 O 4" xref: MassAvg: "303.32" xref: MassMono: "303.121906" xref: Origin: "K, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00239 name: S-methyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-methyl-L-cysteine." [PubMed:10660523, PubMed:11875433, PubMed:1339288, RESID:AA0234, UniMod:34#C] subset: PSI-MOD-slim synonym: "(R)-2-amino-3-(methylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "ACT_SITE S-methylcysteine intermediate" EXACT UniProt-feature [] synonym: "L-3-(methylthio)alanine" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES S-methylcysteine" EXACT UniProt-feature [] synonym: "S-methyl-L-cysteine" EXACT RESID-name [] synonym: "S-methylated L-cysteine" EXACT PSI-MOD-alternate [] synonym: "SMeCys" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0" xref: DiffMono: "14.015650" xref: Formula: "C 4 H 7 N 1 O 1 S 1" xref: MassAvg: "117.17" xref: MassMono: "117.024835" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00654 ! S-methylated residue is_a: MOD:01682 ! monomethylated L-cysteine [Term] id: MOD:00240 name: 4-hydroxy-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 4-hydroxy-L-lysine." [PubMed:4005040, RESID:AA0235] comment: This modification was not structurally confirmed. Later 5-hydroxy-L-lysine was found at a homologous position in the same protein from closely related species. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "(2S,4R)-2,6-diamino-4-hydroxyhexanoic acid" EXACT RESID-systematic [] synonym: "4-hydroxy-L-lysine" EXACT RESID-name [] synonym: "4-hydroxylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "4HyLys" EXACT PSI-MOD-label [] synonym: "alpha,epsilon-diamino-gamma-hydroxycaproic acid" EXACT RESID-alternate [] synonym: "L-threo-gamma-hydroxylysine" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 12 N 2 O 2" xref: MassAvg: "144.17" xref: MassMono: "144.089878" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01047 ! monohydroxylated lysine [Term] id: MOD:00241 name: N4-hydroxymethyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4-hydroxymethyl-L-asparagine." [RESID:AA0236, UniMod:414] comment: N4-methyl-L-asparagine, see MOD:0079, was found at a homologous position of the same protein in a closely related species. Since the peptide containing this modification was obtained by enzymatic cleavage, not cyanogen bromide cleavage, it could have experienced oxidation of the following methionine residue, leading to the erroneous attribution of a mass of 29 for the modification rather than 14. comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "(2S)-2-amino-4-[(hydroxymethyl)amino]-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "2-amino-N4-hydroxymethylbutanediamic acid" EXACT RESID-alternate [] synonym: "beta-hydroxymethylasparagine" EXACT RESID-alternate [] synonym: "Hydroxymethyl" RELATED PSI-MS-label [] synonym: "hydroxymethyl" RELATED UniMod-description [] synonym: "N(gamma)-hydroxymethylasparagine" EXACT RESID-alternate [] synonym: "N4-hydroxymethyl-L-asparagine" EXACT RESID-name [] synonym: "N4-hydroxymethylasparagine" EXACT RESID-alternate [] xref: DiffAvg: "30.03" xref: DiffFormula: "C 1 H 2 N 0 O 1" xref: DiffMono: "30.010565" xref: Formula: "C 5 H 8 N 2 O 3" xref: MassAvg: "144.13" xref: MassMono: "144.053492" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00242 name: O-(ADP-ribosyl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(ADP-ribosyl)-L-serine." [PubMed:15842200, PubMed:3141412, RESID:AA0237, UniMod:213#S] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-propanoic acid" EXACT RESID-systematic [] synonym: "ADP Ribose addition" RELATED UniMod-description [] synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] synonym: "MOD_RES ADP-ribosylserine" EXACT UniProt-feature [] synonym: "O-(ADP-ribosyl)-L-serine" EXACT RESID-name [] synonym: "O3-(ADP-ribosyl)-L-serine" EXACT RESID-alternate [] synonym: "O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-serine" EXACT RESID-alternate [] synonym: "O3-alpha-D-ribofuranosyl-L-serine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] synonym: "OADPRibSer" EXACT PSI-MOD-label [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "C 18 H 26 N 6 O 15 P 2" xref: MassAvg: "628.38" xref: MassMono: "628.093137" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00243 name: L-cysteine oxazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0238] comment: Cross-link 2. synonym: "2-(1-azanyl-2-sulfanylethyl)-4-oxazolecarboxylic acid" EXACT RESID-alternate [] synonym: "2-[(1R)-1-amino-2-sulfanylethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Oxazole-4-carboxylic acid (Cys-Ser)" EXACT UniProt-feature [] synonym: "L-cysteine oxazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 6 H 6 N 2 O 2 S 1" xref: MassAvg: "170.19" xref: MassMono: "170.014998" xref: Origin: "C, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00244 name: L-cysteine oxazoline-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazoline-4-carboxylic acid." [PubMed:1880060, RESID:AA0239] comment: Cross-link 2. synonym: "(4S)-2-[(1R)-1-amino-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Oxazoline-4-carboxylic acid (Cys-Ser)" EXACT UniProt-feature [] synonym: "L-cysteine oxazoline-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 8 N 2 O 2 S 1" xref: MassAvg: "172.20" xref: MassMono: "172.030649" xref: Origin: "C, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) [Term] id: MOD:00245 name: glycine oxazole-4-carboxylic acid def: "A protein modification that effectively crosslinks a glycine residue and an L-serine residue to form glycine oxazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0240] comment: Cross-link 2. synonym: "2-aminomethyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-azanylmethyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Oxazole-4-carboxylic acid (Gly-Ser)" EXACT UniProt-feature [] synonym: "glycine oxazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1" xref: DiffMono: "-20.026215" xref: Formula: "C 5 H 4 N 2 O 2" xref: MassAvg: "124.10" xref: MassMono: "124.027277" xref: Origin: "G, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00246 name: glycine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form glycine thiazole-4-carboxylic acid." [ChEBI:21276, PubMed:8183941, PubMed:8895467, RESID:AA0241] comment: Cross-link 2. synonym: "2-(aminomethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-(azanylmethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Gly-Cys)" EXACT UniProt-feature [] synonym: "glycine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 5 H 4 N 2 O 1 S 1" xref: MassAvg: "140.16" xref: MassMono: "140.004434" xref: Origin: "C, G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00247 name: L-serine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-serine thiazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0242] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Ser-Cys)" EXACT UniProt-feature [] synonym: "L-serine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 6 H 6 N 2 O 2 S 1" xref: MassAvg: "170.19" xref: MassMono: "170.014998" xref: Origin: "C, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00248 name: L-phenylalanine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0243] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-2-phenylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-phenylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Phe-Cys)" EXACT UniProt-feature [] synonym: "L-phenylalanine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 12 H 10 N 2 O 1 S 1" xref: MassAvg: "230.29" xref: MassMono: "230.051384" xref: Origin: "C, F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00249 name: L-cysteine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks two L-cysteine residues to form L-cysteine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0244] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Cys-Cys)" EXACT UniProt-feature [] synonym: "L-cysteine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 6 H 6 N 2 O 1 S 2" xref: MassAvg: "186.25" xref: MassMono: "185.992155" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00250 name: L-lysine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to form L-lysine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0245] comment: Cross-link 2. Lysine is now thought not to be encoded in the peptide sequence modified to produce GE2270. See RESID:AA0470. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "2-[(1S)-1,5-diaminopentyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1,5-bis(azanyl)pentyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "L-lysine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 9 H 13 N 3 O 1 S 1" xref: MassAvg: "211.28" xref: MassMono: "211.077933" xref: Origin: "C, K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00251 name: O-(phospho-5'-DNA)-L-serine def: "A protein modification that effectively crosslinks an L-serine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-serine." [PubMed:7142163, PubMed:7265205, RESID:AA0246] synonym: "(S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)propanoic acid" EXACT RESID-systematic [] synonym: "ACT_SITE O-(5'-phospho-DNA)-serine intermediate" EXACT UniProt-feature [] synonym: "MOD_RES O-(5'-phospho-DNA)-serine" EXACT UniProt-feature [] synonym: "O-(phospho-5'-DNA)-L-serine" EXACT RESID-name [] synonym: "O3-(phospho-5'-DNA)-L-serine" EXACT RESID-alternate [] synonym: "O3-L-serine 5'-DNA phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "78.97" xref: DiffFormula: "C 0 H 0 N 0 O 3 P 1" xref: DiffMono: "78.958505" xref: Formula: "C 3 H 5 N 1 O 5 P 1" xref: MassAvg: "166.05" xref: MassMono: "165.990534" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00750 ! deoxyribonucleic acid linked residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00252 name: keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine def: "A protein modification that effectively cross-links an L-threonine residue to the polymer keratan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:1417734, PubMed:3472204, RESID:AA0247] synonym: "keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT RESID-name [] synonym: "keratosulfate" EXACT RESID-alternate [] synonym: "poly[beta-1,4-(2-acetamido-2-deoxy-6-sulfate D-glucosyl)-beta-1,3-D-galactosyl]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-threonine" EXACT RESID-systematic [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0" xref: DiffMono: "-1.007825" xref: Formula: "C 4 H 6 N 1 O 2" xref: MassAvg: "100.10" xref: MassMono: "100.039853" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00005 ! O-glycosyl-L-threonine [Term] id: MOD:00253 name: L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Sec) def: "A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:14235557, PubMed:2211698, PubMed:8052647, PubMed:9036855, RESID:AA0248#SEC, UniMod:415] xref: DiffAvg: "1572.02" xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 Se 0" xref: DiffMono: "1572.985775" xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1" xref: MassAvg: "1722.07" xref: MassMono: "1723.939410" xref: Origin: "U" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00744 ! molybdenum pterin containing modification is_a: MOD:01158 ! modified L-selenocysteine residue [Term] id: MOD:00254 name: O4'-(phospho-5'-RNA)-L-tyrosine def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-tyrosine." [PubMed:1702164, PubMed:209034, PubMed:217003, PubMed:6264310, RESID:AA0249] synonym: "(S)-2-amino-3-[4-(5'-ribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES O-(5'-phospho-RNA)-tyrosine" EXACT UniProt-feature [] synonym: "O4'-(phospho-5'-RNA)-L-tyrosine" EXACT RESID-name [] synonym: "O4'-L-tyrosine 5'-RNA phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 9 H 10 N 1 O 5 P 1" xref: MassAvg: "243.15" xref: MassMono: "243.029659" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00751 ! ribonucleic acid linked residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00255 name: 3-(3'-L-histidyl)-L-tyrosine def: "A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3-(3'-L-histidyl)-L-tyrosine." [PubMed:9144772, RESID:AA0250] comment: Cross-link 2. synonym: "(2S,3R)-2-amino-3-(5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "3-(3'-L-histidyl)-L-tyrosine" EXACT RESID-name [] synonym: "3-(N3'-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "3-(pi-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "3-(pros-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "beta-(N(delta)-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "beta-(N3'-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "CROSSLNK 3'-histidyl-3-tyrosine (His-Tyr)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 15 H 14 N 4 O 3" xref: MassAvg: "298.30" xref: MassMono: "298.106590" xref: Origin: "H, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00256 name: L-methionine sulfone def: "A protein modification that dioxygenates an L-methionine residue to L-methionine sulfone." [DeltaMass:205, OMSSA:115, PubMed:12686488, PubMed:7786407, PubMed:7791219, PubMed:9252331, RESID:AA0251, UniMod:425#M] comment: DeltaMass gives the formula C 5 H 9 N 3 O 1 S 1 with mass 163 subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-(methylsulfonyl)butanoic acid" EXACT RESID-systematic [] synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] synonym: "L-methionine S,S-dioxide" EXACT RESID-alternate [] synonym: "L-methionine sulfone" EXACT RESID-name [] synonym: "MethionylSulphone" EXACT DeltaMass-label [] synonym: "MetO2" EXACT PSI-MOD-label [] synonym: "MOD_RES Methionine sulfone" EXACT UniProt-feature [] synonym: "Oxidation of Methionine (to Sulphone)" EXACT DeltaMass-label [] synonym: "S,S-dioxymethionine" EXACT RESID-alternate [] synonym: "suphonem" EXACT OMSSA-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2 S 0" xref: DiffMono: "31.989829" xref: Formula: "C 5 H 9 N 1 O 3 S 1" xref: MassAvg: "163.19" xref: MassMono: "163.030314" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00709 ! sulfur oxygenated L-methionine is_a: MOD:01855 ! sulfur dioxygenated residue [Term] id: MOD:00257 name: dipyrrolylmethanemethyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to dipyrrolylmethanemethyl-L-cysteine." [PubMed:3042456, PubMed:3196304, PubMed:3421931, PubMed:8727319, RESID:AA0252, UniMod:416] synonym: "(2S)-3-[5-[4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methyl-4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid" EXACT RESID-systematic [] synonym: "3-[5-(3-acetic acid-4-propanoic acid-1-pyrrol-2-yl)methyl-3-acetic acid-4-propanoic acid-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid" EXACT RESID-alternate [] synonym: "dipyrrole cofactor" EXACT RESID-alternate [] synonym: "Dipyrrolylmethanemethyl" RELATED PSI-MS-label [] synonym: "dipyrrolylmethanemethyl" RELATED UniMod-description [] synonym: "dipyrrolylmethanemethyl-L-cysteine" EXACT RESID-name [] synonym: "dipyrrolylmethyl-L-cysteine" EXACT RESID-alternate [] synonym: "dipyrromethane cofactor" EXACT RESID-alternate [] synonym: "MOD_RES S-(dipyrrolylmethanemethyl)cysteine" EXACT UniProt-feature [] synonym: "pyrromethane cofactor" EXACT RESID-alternate [] xref: DiffAvg: "418.40" xref: DiffFormula: "C 20 H 22 N 2 O 8 S 0" xref: DiffMono: "418.137616" xref: Formula: "C 23 H 27 N 3 O 9 S 1" xref: MassAvg: "521.54" xref: MassMono: "521.146800" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00258 name: S-(2-aminovinyl)-3-methyl-D-cysteine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form S-(2-aminovinyl)-3-methyl-D-cysteine." [PubMed:9119018, RESID:AA0253] comment: Cross-link 2. synonym: "(2S,3S)-2-amino-3-[((Z)-2-aminoethenyl)sulfanyl]butanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-[(2-aminovinyl)sulfanyl]butanoic acid" EXACT RESID-alternate [] synonym: "CROSSLNK S-(2-aminovinyl)-3-methyl-D-cysteine (Thr-Cys)" EXACT UniProt-feature [] synonym: "decarboxylated methyllanthionine" EXACT RESID-alternate [] synonym: "S-(2-aminovinyl)-3-methyl-D-cysteine" EXACT RESID-name [] xref: DiffAvg: "-64.04" xref: DiffFormula: "C -1 H -4 N 0 O -3 S 0" xref: DiffMono: "-64.016044" xref: Formula: "C 6 H 9 N 2 O 1 S 1" xref: MassAvg: "157.21" xref: MassMono: "157.043559" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00687 ! thioether crosslinked residues is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00259 name: O4'-(phospho-5'-DNA)-L-tyrosine def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of DNA through a phosphodiester bond to form O4'-(phospho-5'-DNA)-L-tyrosine." [PubMed:1861973, PubMed:2940511, PubMed:3684578, RESID:AA0254] synonym: "(S)-2-amino-3-[4-(5'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] synonym: "ACT_SITE O-(5'-phospho-DNA)-tyrosine intermediate" EXACT UniProt-feature [] synonym: "MOD_RES O-(5'-phospho-DNA)-tyrosine" EXACT UniProt-feature [] synonym: "O4'-(phospho-5'-DNA)-L-tyrosine" EXACT RESID-name [] synonym: "O4'-L-tyrosine 5'-DNA phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 9 H 10 N 1 O 5 P 1" xref: MassAvg: "243.15" xref: MassMono: "243.029659" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00750 ! deoxyribonucleic acid linked residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00260 name: O-(phospho-5'-DNA)-L-threonine def: "A protein modification that effectively crosslinks an L-threonine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-threonine." [PubMed:3081736, RESID:AA0255] synonym: "(S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)butanoic acid" EXACT RESID-systematic [] synonym: "O-(phospho-5'-DNA)-L-threonine" EXACT RESID-name [] synonym: "O3-(phospho-5'-DNA)-L-threonine" EXACT RESID-alternate [] synonym: "O3-L-threonine 5'-DNA phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "78.97" xref: DiffFormula: "C 0 H 0 N 0 O 3 P 1" xref: DiffMono: "78.958505" xref: Formula: "C 4 H 7 N 1 O 5 P 1" xref: MassAvg: "180.08" xref: MassMono: "180.006184" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00750 ! deoxyribonucleic acid linked residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00261 name: O4'-(phospho-5'-uridine)-L-tyrosine def: "A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphouridine through a phosphodiester bond to form O4'-(phospho-5'-uridine)-L-tyrosine." [DeltaMass:0, PubMed:11467524, PubMed:2885322, RESID:AA0256, UniMod:417#Y] comment: From DeltaMass: Average Mass: 306. subset: PSI-MOD-slim synonym: "(S)-2-amino-3-[4-(5'-uridine phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] synonym: "5'-uridylic-O-tyrosine" EXACT RESID-alternate [] synonym: "hydrogen 5'-uridylate tyrosine ester" EXACT RESID-alternate [] synonym: "MOD_RES O-UMP-tyrosine" EXACT UniProt-feature [] synonym: "O-Uridinylylation (of Tyrosine)" EXACT DeltaMass-label [] synonym: "O4'-(phospho-5'-uridine)-L-tyrosine" EXACT RESID-name [] synonym: "O4'-L-tyrosine 5'-uridine phosphodiester" EXACT RESID-alternate [] synonym: "OUMPTyr" EXACT PSI-MOD-label [] synonym: "PhosphoUridine" RELATED PSI-MS-label [] synonym: "uridine phosphodiester" RELATED UniMod-description [] xref: DiffAvg: "306.17" xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1" xref: DiffMono: "306.025302" xref: Formula: "C 18 H 20 N 3 O 10 P 1" xref: MassAvg: "469.34" xref: MassMono: "469.088630" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01166 ! uridylated residue [Term] id: MOD:00262 name: N-(L-glutamyl)-L-tyrosine def: "A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and a free L-tyrosine." [ChEBI:21477, PubMed:6387372, PubMed:8093886, RESID:AA0257] comment: Cross-link 2. synonym: "(S,S)-2-(2-aminopentanedio-1-yl)amino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "L-glutamyl L-tyrosine" EXACT RESID-name [] synonym: "N-(L-glutamyl)-L-tyrosine" EXACT RESID-alternate [] synonym: "SITE Involved in polymerization" EXACT UniProt-feature [] xref: DiffAvg: "-17.01" xref: DiffFormula: "C 0 H -1 N 0 O -1" xref: DiffMono: "-17.002740" xref: Formula: "C 14 H 16 N 2 O 5" xref: MassAvg: "292.29" xref: MassMono: "292.105922" xref: Origin: "E, Y" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00263 name: S-phycoviolobilin-L-cysteine def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoviolobilin." [PubMed:2106585, PubMed:3208761, RESID:AA0258, UniMod:387] synonym: "(4S)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-4,5-dihydro-2,7,13,17-tetramethyl-(21H,22H,24H)-biladiene-bc-1,19-dione" EXACT RESID-systematic [] synonym: "BINDING Phycoviolobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] synonym: "cryptobiliviolin" EXACT RESID-alternate [] synonym: "cryptoviolin" EXACT RESID-alternate [] synonym: "cryptoviolobilin" EXACT RESID-alternate [] synonym: "PBV" EXACT RESID-alternate [] synonym: "Phycocyanobilin" RELATED PSI-MS-label [] synonym: "phycocyanobilin" RELATED UniMod-description [] synonym: "PVB" EXACT RESID-alternate [] synonym: "PXB" EXACT RESID-alternate [] synonym: "S-phycobiliviolin-L-cysteine" EXACT RESID-alternate [] synonym: "S-phycoviolobilin-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "586.69" xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" xref: DiffMono: "586.279135" xref: Formula: "C 36 H 43 N 5 O 7 S 1" xref: MassAvg: "689.83" xref: MassMono: "689.288320" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00264 name: phycoerythrobilin-bis-L-cysteine def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycoerythrobilin." [PubMed:3208761, PubMed:3838747, RESID:AA0259] comment: Cross-link 2. synonym: "(2S,3R,16R)-3,18-bis-[(R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] synonym: "3,18-bis-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-biladiene-ab-8,12-dipropanoic acid" EXACT RESID-alternate [] synonym: "BINDING Phycoerythrobilin chromophore (covalent; via 2 links)" EXACT UniProt-feature [] synonym: "PEB" EXACT RESID-alternate [] synonym: "phycoerythrobilin biscysteine adduct" EXACT RESID-alternate [] synonym: "phycoerythrobilin-bis-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "586.69" xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" xref: DiffMono: "586.279135" xref: Formula: "C 39 H 48 N 6 O 8 S 2" xref: MassAvg: "792.97" xref: MassMono: "792.297505" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00265 name: phycourobilin-bis-L-cysteine def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycourobilin." [PubMed:3208761, PubMed:3838665, PubMed:3838747, PubMed:8876649, RESID:AA0260] comment: Cross-link 2. synonym: "3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-2,7,13,17-tetramethyl-1,19-dioxo-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-8,12-dipropanoic acid" EXACT RESID-alternate [] synonym: "3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-1,19(4H,16H)-dione" EXACT RESID-systematic [] synonym: "BINDING Phycourobilin chromophore (covalent; via 2 links)" EXACT UniProt-feature [] synonym: "phycourobilin biscysteine adduct" EXACT RESID-alternate [] synonym: "phycourobilin-bis-L-cysteine" EXACT RESID-name [] synonym: "PUB" EXACT RESID-alternate [] xref: DiffAvg: "586.69" xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" xref: DiffMono: "586.279135" xref: Formula: "C 39 H 48 N 6 O 8 S 2" xref: MassAvg: "792.97" xref: MassMono: "792.297505" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00266 name: N-L-glutamyl-poly-L-glutamic acid def: "A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and one or more free L-glutamic acid molecules to form N-(L-glutamyl)-poly-L-glutamic acid." [PubMed:2570347, PubMed:328274, RESID:AA0261] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 10 H 15 N 2 O 7" xref: MassAvg: "275.24" xref: MassMono: "275.087926" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00267 name: L-cysteine sulfinic acid def: "A protein modification that effectively dioxygenates an L-cysteine residue to L-cysteine sulfinic acid." [ChEBI:16345, OMSSA:162, PubMed:12686488, PubMed:9252331, PubMed:9586994, RESID:AA0262, UniMod:425#C] comment: "Hyun Ae Woo, et. al., Science 300 (5619), 653-656" subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-sulfinopropanoic acid" EXACT RESID-systematic [] synonym: "2-amino-2-carboxyethanesulfinic acid" EXACT RESID-alternate [] synonym: "2-amino-3-(dioxido-lambda(6)-sulfanyl)propanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-amino-3-sulfonylpropanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "3-sulfinoalanine" EXACT RESID-alternate [] synonym: "3-sulphinoalanine" EXACT RESID-alternate [] synonym: "CysO2H" EXACT PSI-MOD-label [] synonym: "cysteine sulphinic acid" EXACT RESID-alternate [] synonym: "cysteine-S,S-dioxide [tautomer]" EXACT RESID-alternate [] synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] synonym: "L-cysteine sulfinic acid" EXACT RESID-name [] synonym: "MOD_RES Cysteine sulfinic acid (-SO2H)" EXACT UniProt-feature [] synonym: "S-cysteinesulfinic acid" EXACT RESID-alternate [] synonym: "S-sulfinocysteine" EXACT RESID-alternate [] synonym: "sulfinicacid" EXACT OMSSA-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2 S 0" xref: DiffMono: "31.989829" xref: Formula: "C 3 H 5 N 1 O 3 S 1" xref: MassAvg: "135.14" xref: MassMono: "134.999014" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00708 ! sulfur oxygenated L-cysteine is_a: MOD:01855 ! sulfur dioxygenated residue [Term] id: MOD:00268 name: L-3',4',5'-trihydroxyphenylalanine def: "A protein modification that effectively converts an L-tyrosine residue to L-3',4',5'-trihydroxyphenylalanine." [DeltaMass:0, PubMed:12686488, PubMed:12771378, PubMed:8554314, PubMed:9252331, PubMed:9434739, RESID:AA0263, UniMod:425#Y] comment: From DeltaMass: Average Mass: 32 synonym: "(S)-2-amino-3-(3,4,5-trihydroxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA)" EXACT DeltaMass-label [] synonym: "35Hy2Tyr" EXACT PSI-MOD-label [] synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] synonym: "L-3',4',5'-trihydroxyphenylalanine" EXACT RESID-name [] synonym: "L-3,4,5-TOPA" EXACT RESID-alternate [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 9 H 9 N 1 O 4" xref: MassAvg: "195.17" xref: MassMono: "195.053158" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00428 ! dihydroxylated residue is_a: MOD:00707 ! hydroxylated tyrosine [Term] id: MOD:00269 name: O-(sn-1-glycerophosphoryl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(sn-1-glycerophosphoryl)-L-serine." [PubMed:8645220, RESID:AA0264, UniMod:419#S] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-[(2Xi)-2,3-dihydroxypropyl]phosphonoxypropanoic acid" EXACT RESID-systematic [] synonym: "alpha-glycerophosphoryl serine" EXACT RESID-alternate [] synonym: "Glycerophospho" RELATED PSI-MS-label [] synonym: "glycerophospho" RELATED UniMod-description [] synonym: "glycerophosphoserine" EXACT RESID-alternate [] synonym: "MOD_RES O-(sn-1-glycerophosphoryl)serine" EXACT UniProt-feature [] synonym: "O-(sn-1-glycerophosphoryl)-L-serine" EXACT RESID-name [] synonym: "O3-(sn-1-glycerophosphoryl)-L-serine" EXACT RESID-alternate [] synonym: "O3-2,3-dihydroxypropyl hydrogen phosphate-L-serine ester" EXACT RESID-alternate [] synonym: "O3-L-serine glyceryl-1-phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "154.06" xref: DiffFormula: "C 3 H 7 N 0 O 5 P 1" xref: DiffMono: "154.003110" xref: Formula: "C 6 H 12 N 1 O 7 P 1" xref: MassAvg: "241.14" xref: MassMono: "241.035138" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00270 name: 1-thioglycine (internal) def: "A protein modification that effectively converts a glycine residue to an internal 1-thioglycine." [PubMed:11463785, PubMed:9367957, RESID:AA0265#INT] comment: This modification occurs naturally in two forms. At an interior peptide location it exists as aminoethanethionic acid (or aminoethanethioic O-acid). At the carboxyl-terminal it exists as aminoethanethiolic acid (or aminoethanethioic S-acid). subset: PSI-MOD-slim synonym: "1-thioglycine" EXACT RESID-name [] synonym: "2-amino-1-sulfanylethanone" EXACT RESID-alternate [] synonym: "aminoethanethioic acid" EXACT RESID-systematic [] synonym: "aminoethanethioic O-acid" EXACT RESID-alternate [] synonym: "aminoethanethionic acid" EXACT RESID-alternate [] synonym: "aminothioacetic acid" EXACT RESID-alternate [] synonym: "Carboxy->Thiocarboxy" RELATED PSI-MS-label [] synonym: "MOD_RES 1-thioglycine" EXACT UniProt-feature [] synonym: "S(O)Gly" EXACT PSI-MOD-label [] synonym: "thiocarboxylic acid" RELATED UniMod-description [] xref: DiffAvg: "16.06" xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1" xref: DiffMono: "15.977156" xref: Formula: "C 2 H 3 N 1 S 1" xref: MassAvg: "73.11" xref: MassMono: "72.998620" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01625 ! 1-thioglycine [Term] id: MOD:00271 name: heme P460-bis-L-cysteine-L-tyrosine def: "A protein modification that effectively results from forming an adduct between two cysteine residues, the C-3' of a tyrosine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:8325841, PubMed:9095195, RESID:AA0266] comment: Cross-link 3. synonym: "(10S,11S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-10-(2-hydroxy-5-[(S)-2-amino-2-carboxy]ethylphenyl)-3,8,13,17-tetramethyl-21H,23H-10,11-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature [] synonym: "bis(S-cysteinyl)-(tyros-3'-yl)-heme" EXACT RESID-alternate [] synonym: "heme P460-bis-L-cysteine-L-tyrosine" EXACT RESID-name [] xref: DiffAvg: "614.48" xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4 S 0" xref: DiffMono: "614.161643" xref: Formula: "C 49 Fe 1 H 49 N 7 O 8 S 2" xref: MassAvg: "983.94" xref: MassMono: "983.243341" xref: Origin: "C, C, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00272 name: O-(phospho-5'-adenosine)-L-threonine def: "A protein modification that effectively crosslinks an L-threonine residue and 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-threonine." [PubMed:2989287, PubMed:8917428, RESID:AA0267, UniMod:405#T] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(5'-adenosine phosphonoxy)butanoic acid" EXACT RESID-systematic [] synonym: "5'-adenylic-O3-L-threonine" EXACT RESID-alternate [] synonym: "ACT_SITE O-AMP-threonine intermediate" EXACT UniProt-feature [] synonym: "AMP binding site" RELATED UniMod-description [] synonym: "beta-5'-adenylic-L-threonine" EXACT RESID-alternate [] synonym: "L-threonine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate [] synonym: "MOD_RES O-AMP-threonine" EXACT UniProt-feature [] synonym: "O(gamma)-5'-adenylic-L-threonine" EXACT RESID-alternate [] synonym: "O-(phospho-5'-adenosine)-L-threonine" EXACT RESID-name [] synonym: "O3-(phospho-5'-adenosine)-L-threonine" EXACT RESID-alternate [] synonym: "O3-L-threonine 5'-adenosine phosphodiester" EXACT RESID-alternate [] synonym: "Phosphoadenosine" RELATED PSI-MS-label [] xref: DiffAvg: "329.21" xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" xref: DiffMono: "329.052520" xref: Formula: "C 14 H 19 N 6 O 8 P 1" xref: MassAvg: "430.31" xref: MassMono: "430.100198" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01165 ! adenylated residue [Term] id: MOD:00273 name: tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide def: "A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a four-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide." [PubMed:12764602, RESID:AA0268] comment: Cross-link 7; secondary to RESID:AA0269. synonym: "4Fe-2S-3O cluster" EXACT RESID-alternate [] synonym: "hybrid four iron cluster 2" EXACT RESID-alternate [] synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S)" EXACT UniProt-feature [] synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S); via persulfide group" EXACT UniProt-feature [] synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogen" EXACT UniProt-feature [] synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-iron-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic [] synonym: "prismane iron-sulfur cofactor" RELATED RESID-misnomer [] synonym: "tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide" EXACT RESID-name [] xref: DiffAvg: "360.50" xref: DiffFormula: "C 0 Fe 4 H -7 N 0 O 3 S 3" xref: DiffMono: "360.585932" xref: Formula: "C 28 Fe 4 H 34 N 9 O 14 S 7" xref: MassAvg: "1168.43" xref: MassMono: "1167.766769" xref: Origin: "C, C, C, C, E, E, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00274 name: L-cysteine persulfide def: "A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a sulfanyl group, forming a disulfanyl group, and converting an L-cysteine residue to L-cysteine persulfide." [ChEBI:28839, PubMed:15096637, PubMed:4276457, PubMed:8161529, RESID:AA0269, UniMod:421] subset: PSI-MOD-slim synonym: "(R)-2-amino-3-disulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-disulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-hydrodisulfidopropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-hydropersulfidopropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-persulfhydrylpropanoic acid" EXACT RESID-alternate [] synonym: "3-(thiosulfeno)-alanine" EXACT RESID-alternate [] synonym: "3-disulfanylalanine" EXACT RESID-alternate [] synonym: "ACT_SITE Cysteine persulfide intermediate" EXACT UniProt-feature [] synonym: "L-cysteine persulfide" EXACT RESID-name [] synonym: "MOD_RES Cysteine persulfide" EXACT UniProt-feature [] synonym: "persulfide" RELATED UniMod-description [] synonym: "S-mercaptocysteine" EXACT RESID-alternate [] synonym: "S-sulfanylcysteine" EXACT RESID-alternate [] synonym: "Sulfide" RELATED PSI-MS-label [] synonym: "thiocysteine" EXACT RESID-alternate [] xref: DiffAvg: "32.06" xref: DiffFormula: "C 0 H 0 N 0 O 0 S 1" xref: DiffMono: "31.972071" xref: Formula: "C 3 H 5 N 1 O 1 S 2" xref: MassAvg: "135.20" xref: MassMono: "134.981256" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01886 ! thiolated residue [Term] id: MOD:00275 name: 3'-(1'-L-histidyl)-L-tyrosine def: "A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3'-(1'-L-histidyl)-L-tyrosine." [ChEBI:19837, PubMed:10338009, RESID:AA0270] comment: Cross-link 2. subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-[1-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenyl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-systematic [] synonym: "3'-(1'-L-histidyl)-L-tyrosine" EXACT RESID-name [] synonym: "3'-(N(epsilon)-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "3'-(N1'-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "3'-(tau-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "3'-(tele-histidyl)tyrosine" EXACT RESID-alternate [] synonym: "CROSSLNK 1'-histidyl-3'-tyrosine (His-Tyr)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 15 H 14 N 4 O 3" xref: MassAvg: "298.30" xref: MassMono: "298.106590" xref: Origin: "H, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00276 name: heme P460-bis-L-cysteine-L-lysine def: "A protein modification that effectively results from forming an adduct between two cysteine residues, a lysine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12709052, PubMed:9237682, RESID:AA0271] comment: Cross-link 3. synonym: "(19S,20S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-20-([(S)-5-amino-5-carboxypentyl]amino)-3,8,13,17-tetramethyl-21H,23H-19,20-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature [] synonym: "bis(S-cysteinyl)-N6-lysino-heme" EXACT RESID-alternate [] synonym: "heme P460-bis-L-cysteine-L-lysine" EXACT RESID-name [] xref: DiffAvg: "614.48" xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4 S 0" xref: DiffMono: "614.161643" xref: Formula: "C 46 Fe 1 H 52 N 8 O 7 S 2" xref: MassAvg: "948.94" xref: MassMono: "948.274976" xref: Origin: "C, C, K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00277 name: 5-methyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to 5-methyl-L-arginine." [PubMed:10660523, PubMed:11875433, PubMed:9367957, RESID:AA0272] synonym: "(2S,5S)-2-amino-5-carbamimidamidohexanoic acid" EXACT RESID-systematic [] synonym: "2-amino-5-guanidinohexanoic acid" EXACT RESID-alternate [] synonym: "4-methylarginine" RELATED RESID-misnomer [] synonym: "5-methyl-L-arginine" EXACT RESID-name [] synonym: "5-methylated L-arginine" EXACT PSI-MOD-alternate [] synonym: "C5Me1Arg" EXACT PSI-MOD-label [] synonym: "delta-methylarginine" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES 5-methylarginine" EXACT UniProt-feature [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 14 N 4 O 1" xref: MassAvg: "170.22" xref: MassMono: "170.116761" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00414 ! monomethylated L-arginine is_a: MOD:00656 ! C-methylated residue [Term] id: MOD:00278 name: 2-methyl-L-glutamine def: "A protein modification that effectively converts an L-glutamine residue to 2-methyl-L-glutamine." [PubMed:10660523, PubMed:11875433, PubMed:9367957, RESID:AA0273] synonym: "(S)-2-amino-2-methylpentanediamic acid" EXACT RESID-systematic [] synonym: "2-methyl-L-glutamine" EXACT RESID-name [] synonym: "2-methylated L-glutamine" EXACT PSI-MOD-alternate [] synonym: "2-methylglutamine" EXACT RESID-alternate [] synonym: "alpha-methylglutamine" EXACT RESID-alternate [] synonym: "C2MeGln" EXACT PSI-MOD-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES 2-methylglutamine" EXACT UniProt-feature [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 6 H 10 N 2 O 2" xref: MassAvg: "142.16" xref: MassMono: "142.074228" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00656 ! C-methylated residue is_a: MOD:00722 ! monomethylated L-glutamine [Term] id: MOD:00279 name: N-pyruvic acid 2-iminyl-L-cysteine def: "A protein modification that effectively converts an Lcysteline residue to N-pyruvic acid 2-iminyl-L-cysteine." [PubMed:1388164, RESID:AA0274, UniMod:422#C] subset: PSI-MOD-slim synonym: "(R)-2-(1-carboxy-2-sulfanylethanimino)propanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES N-pyruvate 2-iminyl-cysteine" EXACT UniProt-feature [] synonym: "N-pyruvic acid 2-iminyl" RELATED UniMod-description [] synonym: "N-pyruvic acid 2-iminyl-L-cysteine" EXACT RESID-name [] synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label [] xref: DiffAvg: "70.05" xref: DiffFormula: "C 3 H 2 N 0 O 2 S 0" xref: DiffMono: "70.005479" xref: Formula: "C 6 H 8 N 1 O 3 S 1" xref: MassAvg: "174.19" xref: MassMono: "174.022489" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01170 ! pyruvic acid iminylated residue [Term] id: MOD:00280 name: N-pyruvic acid 2-iminyl-L-valine def: "A protein modification that effectively converts an L-valine residue to N-pyruvic acid 2-iminyl-L-valine." [PubMed:2071591, RESID:AA0275, UniMod:422#V] subset: PSI-MOD-slim synonym: "(S)-2-(1-carboxy-2-methylpropanimino)propanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES N-pyruvate 2-iminyl-valine" EXACT UniProt-feature [] synonym: "N-pyruvic acid 2-iminyl" RELATED UniMod-description [] synonym: "N-pyruvic acid 2-iminyl-L-valine" EXACT RESID-name [] synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label [] xref: DiffAvg: "70.05" xref: DiffFormula: "C 3 H 2 N 0 O 2" xref: DiffMono: "70.005479" xref: Formula: "C 8 H 12 N 1 O 3" xref: MassAvg: "170.19" xref: MassMono: "170.081718" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00920 ! modified L-valine residue is_a: MOD:01170 ! pyruvic acid iminylated residue [Term] id: MOD:00281 name: 3'-heme-L-histidine def: "A protein modification that effectively results from forming an adduct between the pros nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12119398, PubMed:12429096, PubMed:12486054, PubMed:9712585, RESID:AA0276] synonym: "2-[1-(N3'-histidyl)ethyl]protoporphyrin IX" EXACT RESID-alternate [] synonym: "3'-heme-L-histidine" EXACT RESID-name [] synonym: "[7-ethenyl-12-((S)-1-[((R)-2-amino-2-carboxyethyl)-3H-imidazol-3-yl]ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] synonym: "BINDING Heme (covalent; via pros nitrogen)" EXACT UniProt-feature [] synonym: "N(delta)-histidyl heme" EXACT RESID-alternate [] synonym: "N(pi)-histidyl heme" EXACT RESID-alternate [] synonym: "N3'-histidyl heme" EXACT RESID-alternate [] synonym: "pros-histidyl heme" EXACT RESID-alternate [] xref: DiffAvg: "616.50" xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4" xref: DiffMono: "616.177293" xref: Formula: "C 40 Fe 1 H 39 N 7 O 5" xref: MassAvg: "753.64" xref: MassMono: "753.236205" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00282 name: S-selenyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-selenyl-L-cysteine." [PubMed:10430865, PubMed:10966817, PubMed:11827487, PubMed:12716131, PubMed:14594807, RESID:AA0277, UniMod:423#C] synonym: "(R)-2-amino-3-(selanylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-hydroselenosulfidopropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-hydroselenylsulfidopropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-hydroselenylthiopropanoic acid" EXACT RESID-alternate [] synonym: "ACT_SITE S-selanylcysteine intermediate" EXACT UniProt-feature [] synonym: "cysteine perselenide" RELATED RESID-misnomer [] synonym: "Delta:Se(1)" RELATED PSI-MS-label [] synonym: "MOD_RES S-selanylcysteine" EXACT UniProt-feature [] synonym: "S-selanyl-L-cysteine" EXACT RESID-name [] synonym: "S-selanylcysteine" EXACT RESID-alternate [] synonym: "S-selenylcysteine" EXACT RESID-alternate [] synonym: "selenyl" RELATED UniMod-description [] xref: DiffAvg: "78.97" xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0 Se 1" xref: DiffMono: "79.916521" xref: Formula: "C 3 H 5 N 1 O 1 S 1 Se 1" xref: MassAvg: "182.11" xref: MassMono: "182.925706" xref: Origin: "C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00745 ! selenium containing residue is_a: MOD:00778 ! residues isobaric at 182.9-183.0 Da is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00283 name: N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine def: "A protein modification that effectively converts an L-lysine residue to an N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine." [PubMed:10550045, PubMed:11349130, RESID:AA0278] synonym: "(alpha)- ([([(5S)-5-amino-5-carboxypentyl]amino)propyl][(methyl)amino])-(omega)-methyl poly[propane-1,3-diyl(methylimino)]" EXACT RESID-systematic [] synonym: "lysine derivative Lys(x)" EXACT RESID-alternate [] synonym: "MOD_RES N6-poly(methylaminopropyl)lysine" EXACT UniProt-feature [] synonym: "N6-[3-([(omega)-(dimethyl)aminopropyl-poly(3-[methylamino]propyl)]amino)propyl]lysine" EXACT RESID-alternate [] synonym: "N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine" EXACT RESID-name [] synonym: "silaffin polycationic lysine derivative" EXACT RESID-alternate [] xref: DiffAvg: "426.74" xref: DiffFormula: "C 24 H 54 N 6 O 0" xref: DiffMono: "426.440996" xref: Formula: "C 30 H 66 N 8 O 1" xref: MassAvg: "554.91" xref: MassMono: "554.535959" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00284 name: dihydroxyheme-L-aspartate ester-L-glutamate ester def: "A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:10447690, RESID:AA0279] comment: Cross-link 2. synonym: "1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester" EXACT RESID-alternate [] synonym: "[13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-7,12-diethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] synonym: "BINDING Heme (covalent; via 2 links)" EXACT UniProt-feature [] synonym: "dihydroxyheme-L-aspartate ester-L-glutamate ester" EXACT RESID-name [] synonym: "peroxidase heme cofactor" EXACT RESID-alternate [] xref: DiffAvg: "612.47" xref: DiffFormula: "C 34 Fe 1 H 28 N 4 O 4" xref: DiffMono: "612.145993" xref: Formula: "C 43 Fe 1 H 40 N 6 O 10" xref: MassAvg: "856.67" xref: MassMono: "856.215529" xref: Origin: "D, E" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00285 name: dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium def: "A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, a methionine residue (forming a sulfonium ether), and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:10447690, PubMed:10480885, PubMed:1320128, PubMed:7840679, RESID:AA0280] comment: Cross-link 3. synonym: "1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester 2-methionine sulfonium" EXACT RESID-alternate [] synonym: "[13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-12-[(S)-(3-amino-3-carboxy)propylsulfoniumethyl]-7-ethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature [] synonym: "dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium" EXACT RESID-name [] synonym: "myeloperoxidase heme cofactor" EXACT RESID-alternate [] xref: DiffAvg: "613.47" xref: DiffFormula: "C 34 Fe 1 H 29 N 4 O 4 S 0" xref: DiffMono: "613.153269" xref: FormalCharge: "1+" xref: Formula: "C 48 Fe 1 H 50 N 7 O 11 S 1" xref: MassAvg: "988.87" xref: MassMono: "988.263290" xref: Origin: "D, E, M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00286 name: L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0281, UniMod:424#C] synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate [] synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-cystein-S-yl-molybdenum" EXACT RESID-systematic [] synonym: "L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name [] synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED UniMod-description [] synonym: "MolybdopterinGD" RELATED PSI-MS-label [] xref: DiffAvg: "1572.02" xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4" xref: DiffMono: "1572.985775" xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 5" xref: MassAvg: "1675.15" xref: MassMono: "1675.994960" xref: Origin: "C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01167 ! molybdopterin guanine dinucleotide [Term] id: MOD:00287 name: (2S,3R,4S)-3,4-dihydroxyproline def: "A protein modification that effectively converts an L-proline residue to a (2S,3R,4S)-3,4-dihydroxyproline." [DeltaMass:0, PubMed:12686488, RESID:AA0282, UniMod:425#P] comment: From DeltaMass: Average Mass: 32. synonym: "(2S,3R,4S)-3,4-dihydroxyproline" EXACT RESID-name [] synonym: "(2S,3R,4S)-3,4-dihydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "2,3-trans-3,4-cis-3,4-dihydroxy-L-proline" EXACT RESID-alternate [] synonym: "2-alpha-3-beta-4-beta-3,4-dihydroxyproline" EXACT RESID-alternate [] synonym: "3,4-dihydroxylated L-proline" EXACT PSI-MOD-alternate [] synonym: "3,4-Dihydroxylation (of Proline)" EXACT DeltaMass-label [] synonym: "34Hy2Pro" EXACT PSI-MOD-label [] synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] synonym: "MOD_RES (3R,4S)-3,4-dihydroxyproline" EXACT UniProt-feature [] synonym: "trans-2,3-cis-3,4-dihydroxy-L-proline" EXACT RESID-alternate [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00866 ! dihydroxylated proline [Term] id: MOD:00288 name: pyrroloquinoline quinone def: "A protein modification that effectively doubly cross-links an L-glutamic acid residue and an L-tyrosine residue with a carbon-carbon bond and a carbon-nitrogen bond to form pyrroloquinoline quinone." [ChEBI:18315, PubMed:1310505, PubMed:7665488, RESID:AA0283] comment: Cross-link 2. synonym: "2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinone" EXACT RESID-alternate [] synonym: "2,7,9-tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dione" EXACT RESID-alternate [] synonym: "4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-5,6]quinoline-2,7,9-tricarboxylic acid" EXACT RESID-systematic [] synonym: "coenzyme PQQ" EXACT RESID-alternate [] synonym: "CROSSLNK Pyrroloquinoline quinone (Glu-Tyr)" EXACT UniProt-feature [] synonym: "methoxatin" EXACT RESID-alternate [] synonym: "pyrroloquinoline quinone" EXACT RESID-name [] xref: DiffAvg: "37.92" xref: DiffFormula: "C 0 H -10 N 0 O 3" xref: DiffMono: "37.906494" xref: Formula: "C 14 H 6 N 2 O 8" xref: MassAvg: "330.21" xref: MassMono: "330.012415" xref: Origin: "E, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00289 name: tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide." [PubMed:9836629, RESID:AA0284] comment: Cross-link 4. synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] synonym: "METAL Iron-sulfur (4Fe-4S); via tele nitrogen" EXACT UniProt-feature [] synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(N1'-histidinoiron)" EXACT RESID-systematic [] synonym: "tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide" EXACT RESID-name [] xref: DiffAvg: "347.59" xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" xref: DiffMono: "347.597831" xref: FormalCharge: "2-" xref: Formula: "C 15 Fe 4 H 18 N 6 O 4 S 7" xref: MassAvg: "794.15" xref: MassMono: "793.684297" xref: Origin: "C, C, C, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00290 name: tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide." [PubMed:7854413, RESID:AA0285] comment: Cross-link 4. synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] synonym: "METAL Iron-sulfur (4Fe-4S); via pros nitrogen" EXACT UniProt-feature [] synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(N3'-histidinoiron)" EXACT RESID-systematic [] synonym: "tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide" EXACT RESID-name [] xref: DiffAvg: "347.59" xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" xref: DiffMono: "347.597831" xref: FormalCharge: "2-" xref: Formula: "C 15 Fe 4 H 18 N 6 O 4 S 7" xref: MassAvg: "794.15" xref: MassMono: "793.684297" xref: Origin: "C, C, C, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00291 name: tris-L-cysteinyl L-aspartato tetrairon tetrasulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-aspartato tetrairon tetrasulfide." [PubMed:7819255, PubMed:9283079, RESID:AA0286] comment: Cross-link 4. synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(O4-aspartatoiron)" EXACT RESID-systematic [] synonym: "tris-L-cysteinyl L-aspartato tetrairon tetrasulfide" EXACT RESID-name [] xref: DiffAvg: "347.59" xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" xref: DiffMono: "347.597831" xref: FormalCharge: "2-" xref: Formula: "C 13 Fe 4 H 16 N 4 O 6 S 7" xref: MassAvg: "772.09" xref: MassMono: "771.652328" xref: Origin: "C, C, C, D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00292 name: N6-pyruvic acid 2-iminyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-pyruvic acid 2-iminyl-L-lysine." [PubMed:1463470, PubMed:7853400, PubMed:9047371, RESID:AA0287, UniMod:422#K] synonym: "(2S)-2-amino-6-([1-carboxyethylidene]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "ACT_SITE Schiff-base intermediate with substrate" EXACT UniProt-feature [] synonym: "N-pyruvic acid 2-iminyl" RELATED UniMod-description [] synonym: "N6-pyruvic acid 2-iminyl-L-lysine" EXACT RESID-name [] synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label [] xref: DiffAvg: "70.05" xref: DiffFormula: "C 3 H 2 N 0 O 2" xref: DiffMono: "70.005479" xref: Formula: "C 9 H 14 N 2 O 3" xref: MassAvg: "198.22" xref: MassMono: "198.100442" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01170 ! pyruvic acid iminylated residue [Term] id: MOD:00293 name: tris-L-cysteinyl L-serinyl tetrairon tetrasulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-serine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-serinyl tetrairon tetrasulfide." [RESID:AA0288] comment: Cross-link 4. synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(O3-serinyliron)" EXACT RESID-systematic [] synonym: "tris-L-cysteinyl L-serinyl tetrairon tetrasulfide" EXACT RESID-name [] xref: DiffAvg: "347.59" xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" xref: DiffMono: "347.597831" xref: FormalCharge: "2-" xref: Formula: "C 12 Fe 4 H 16 N 4 O 5 S 7" xref: MassAvg: "744.08" xref: MassMono: "743.657414" xref: Origin: "C, C, C, S" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00294 name: bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide def: "A protein modification that effectively converts two L-cysteine residues, an L-histidine residues, an L-serine residue and a four-iron four-sulfur cluster to bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide." [RESID:AA0289] comment: Cross-link 4. synonym: "bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide" EXACT RESID-name [] synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] synonym: "METAL Iron-sulfur (4Fe-4S); via pros nitrogen" EXACT UniProt-feature [] synonym: "tetra-mu3-sulfidobis(S-cysteinyliron)(N3'-histidinoiron)(O3-serinyliron)" EXACT RESID-systematic [] xref: DiffAvg: "347.59" xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" xref: DiffMono: "347.597831" xref: FormalCharge: "2-" xref: Formula: "C 15 Fe 4 H 18 N 6 O 5 S 6" xref: MassAvg: "778.09" xref: MassMono: "777.707141" xref: Origin: "C, C, H, S" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00295 name: O-octanoyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-octanoyl-L-serine." [PubMed:10604470, PubMed:12716131, RESID:AA0290, UniMod:426#S] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(octanoyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "L-serine octanoate ester" EXACT RESID-alternate [] synonym: "LIPID O-octanoyl serine" EXACT UniProt-feature [] synonym: "O-octanoyl-L-serine" EXACT RESID-name [] synonym: "O-octanoylated L-serine" EXACT PSI-MOD-alternate [] synonym: "O3-octanoyl-L-serine" EXACT RESID-alternate [] synonym: "Octanoyl" RELATED PSI-MS-label [] synonym: "octanoyl" RELATED UniMod-description [] synonym: "OOctSer" EXACT PSI-MOD-label [] xref: DiffAvg: "126.20" xref: DiffFormula: "C 8 H 14 N 0 O 1" xref: DiffMono: "126.104465" xref: Formula: "C 11 H 19 N 1 O 3" xref: MassAvg: "213.28" xref: MassMono: "213.136493" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00669 ! O-octanoylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00296 name: O-D-glucuronosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-D-glucuronosyl-L-serine." [PubMed:10858503, PubMed:12716131, PubMed:7398618, RESID:AA0291, UniMod:54#S] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(beta-D-glucopyranuronosyl)propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (GlcA)" EXACT UniProt-feature [] synonym: "Glucuronyl" RELATED PSI-MS-label [] synonym: "N-glucuronylation" RELATED UniMod-description [] synonym: "O-D-glucuronosyl-L-serine" EXACT RESID-name [] synonym: "O3-D-glucuronosyl-L-serine" EXACT RESID-alternate [] xref: DiffAvg: "176.12" xref: DiffFormula: "C 6 H 8 N 0 O 6" xref: DiffMono: "176.032088" xref: Formula: "C 9 H 13 N 1 O 8" xref: MassAvg: "263.20" xref: MassMono: "263.064116" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00447 ! N-glucuronylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00297 name: tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide def: "A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] comment: Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate [] synonym: "hybrid nickel-triiron cluster" EXACT RESID-alternate [] synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-nickel-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic [] synonym: "Ni-3Fe-2S-3O cluster" EXACT RESID-alternate [] synonym: "tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide" EXACT RESID-name [] xref: DiffAvg: "363.35" xref: DiffFormula: "C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3" xref: DiffMono: "362.586337" xref: Formula: "C 28 Fe 3 H 34 N 9 Ni 1 O 14 S 7" xref: MassAvg: "1171.28" xref: MassMono: "1169.767174" xref: Origin: "C, C, C, C, E, E, H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00741 ! nickel containing modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00298 name: tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide def: "A protein modification that effectively converts four L-cysteine residues, an L-glutamic acid residue, an L-histidine residue, an L-serine residue and a one-nickel three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [PubMed:2550436, RESID:AA0293] comment: Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate [] synonym: "hybrid nickel-triiron cluster" EXACT RESID-alternate [] synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O3-serinyl 2-nickel-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic [] synonym: "Ni-3Fe-2S-3O cluster" EXACT RESID-alternate [] synonym: "tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide" EXACT RESID-name [] xref: DiffAvg: "363.35" xref: DiffFormula: "C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3" xref: DiffMono: "362.586337" xref: Formula: "C 26 Fe 3 H 32 N 9 Ni 1 O 13 S 7" xref: MassAvg: "1129.24" xref: MassMono: "1127.756609" xref: Origin: "C, C, C, C, E, H, S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00741 ! nickel containing modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00299 name: N6-(L-isoaspartyl)-L-lysine (Asn) def: "A protein modification that effectively crosslinks an L-asparagine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of ammonia." [ChEBI:21862, DeltaMass:0, PubMed:11000116, PubMed:6503713, RESID:AA0294] comment: Cross-link 2. synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate [] synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature [] synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate [] synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate [] synonym: "N-(beta-Aspartyl)-Lysine (Crosslink)" EXACT DeltaMass-label [] synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name [] synonym: "XLNK-4Asp-N6Lys(Asn)" EXACT PSI-MOD-label [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 10 H 15 N 3 O 3" xref: MassAvg: "225.25" xref: MassMono: "225.111341" xref: Origin: "K, N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:00946 ! crosslinked residues with loss of ammonia is_a: MOD:01929 ! N6-(L-isoaspartyl)-L-lysine [Term] id: MOD:00300 name: L-glutamyl-5-poly(ADP-ribose) def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose)." [DeltaMass:0, PubMed:11246023, PubMed:15842200, PubMed:8533153, RESID:AA0295, UniMod:213#E] synonym: "(S)-2-amino-5-poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl]oxy-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "ADP Ribose addition" RELATED UniMod-description [] synonym: "ADP-Ribosyl" RELATED PSI-MS-label [] synonym: "L-glutamyl-5-poly(ADP-ribose)" EXACT RESID-name [] synonym: "L-isoglutamyl-poly(ADP-ribose)" EXACT RESID-alternate [] synonym: "MOD_RES PolyADP-ribosyl glutamic acid" EXACT UniProt-feature [] synonym: "O-ADP-ribosylation (on Glutamate or C terminus)" EXACT DeltaMass-label [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "C 20 H 28 N 6 O 16 P 2" xref: MassAvg: "670.42" xref: MassMono: "670.103702" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00301 name: O-(N-acetylglucosamine-1-phosphoryl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(N-acetylglucosamine-1-phosphoryl)-L-serine." [DeltaMass:0, PubMed:6438439, PubMed:6993483, PubMed:8631906, RESID:AA0296, UniMod:428] synonym: "(2S)-2-amino-3-[([(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy][hydroxy]phosphoryl)oxy]propanoic acid" EXACT RESID-systematic [] synonym: "N-acetylglucosamine-1-phosphoryl" RELATED UniMod-description [] synonym: "O-(N-acetylglucosamine-1-phosphoryl)-L-serine" EXACT RESID-name [] synonym: "O-beta(N-acetyl-glucosamine-alpha1-phosphate)serine" EXACT RESID-alternate [] synonym: "O-GlcNAc-1-phosphorylation (of Serine)" EXACT DeltaMass-label [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine" EXACT RESID-alternate [] synonym: "O3-L-serine 2-(acetylamino)-2-deoxy-D-glucopyranose 1-phosphodiester" EXACT RESID-alternate [] synonym: "PhosphoHexNAc" RELATED PSI-MS-label [] xref: DiffAvg: "283.17" xref: DiffFormula: "C 8 H 14 N 1 O 8 P 1" xref: DiffMono: "283.045703" xref: Formula: "C 11 H 19 N 2 O 10 P 1" xref: MassAvg: "370.25" xref: MassMono: "370.077731" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01804 ! glycosylphosphorylated residue [Term] id: MOD:00302 name: O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine." [PubMed:10037765, PubMed:15649890, RESID:AA0297, UniMod:429] synonym: "O-(alpha-D-mannosyl-1-phosphoryl)-L-serine" EXACT RESID-alternate [] synonym: "O-(D-mannose-1-phosphoryl)-L-serine" EXACT RESID-name [] synonym: "O-[alpha-D-mannopyranosyloxy(hydroxy)phosphoryl]-L-serine" EXACT RESID-systematic [] synonym: "O3-(D-mannose-1-phosphoryl)-L-serine" EXACT RESID-alternate [] synonym: "O3-L-serine alpha-D-mannopyranose 1-phosphodiester" EXACT RESID-alternate [] synonym: "phosphoglycosyl-D-mannose-1-phosphoryl" RELATED UniMod-description [] synonym: "PhosphoHex" RELATED PSI-MS-label [] xref: DiffAvg: "242.12" xref: DiffFormula: "C 6 H 11 N 0 O 8 P 1" xref: DiffMono: "242.019154" xref: Formula: "C 9 H 16 N 1 O 10 P 1" xref: MassAvg: "329.20" xref: MassMono: "329.051182" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01804 ! glycosylphosphorylated residue [Term] id: MOD:00303 name: heptakis-L-histidino tetracopper mu4-sulfide hydroxide def: "A protein modification that effectively converts seven L-histidinine residues and a four-copper one-sulfur one-hydroxide cluster to heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [PubMed:11024061, PubMed:11041839, RESID:AA0298] comment: Cross-link 7. synonym: "heptakis-L-histidino tetracopper mu4-sulfide hydroxide" EXACT RESID-name [] synonym: "mu4-sulfido bis(bis-N1'-histidino copper)(N1'-histidino-N3'-histidino copper)(N3'-histidino hydroxide copper)" EXACT RESID-systematic [] synonym: "nitrous oxide reductase nosZ CuZ cluster" EXACT RESID-alternate [] synonym: "pentakis-L-N1'-histidino-bis-L-N3'-histidino tetracopper sulfide hydroxide" EXACT RESID-alternate [] xref: DiffAvg: "296.19" xref: DiffFormula: "C 0 Cu 4 H -6 N 0 O 1 S 1" xref: DiffMono: "293.638425" xref: Formula: "C 42 Cu 4 H 43 N 21 O 8 S 1" xref: MassAvg: "1256.19" xref: MassMono: "1253.050808" xref: Origin: "H, H, H, H, H, H, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00742 ! copper containing modified residue is_a: MOD:00860 ! sulfur containing modified residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00304 name: L-leucine methyl ester def: "A protein modification that effectively converts an L-leucine residue to L-leucine methyl ester." [PubMed:10191253, PubMed:11875433, PubMed:8206937, RESID:AA0299, UniMod:34#C-term] comment: incidental to RESID:AA0039 subset: PSI-MOD-slim synonym: "2-amino-4-methylpentanoic methyl ester" EXACT RESID-alternate [] synonym: "alpha-aminoisocaproic methyl ester" EXACT RESID-alternate [] synonym: "L-leucine methyl ester" EXACT RESID-name [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "methyl (2S)-2-amino-4-methylpentanoate" EXACT RESID-systematic [] synonym: "methyl esterified L-leucine" EXACT PSI-MOD-alternate [] synonym: "methyl L-leucinate" EXACT RESID-alternate [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES Leucine methyl ester" EXACT UniProt-feature [] synonym: "OMeLeu" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 14 N 1 O 2" xref: MassAvg: "144.19" xref: MassMono: "144.102454" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00662 ! methylated leucine is_a: MOD:01689 ! alpha-carboxyl methylated residue [Term] id: MOD:00305 name: hexakis-L-cysteinyl L-serinyl octairon heptasulfide def: "A protein modification that effectively converts six L-cysteine residues, an L-serine residue and a eight-iron seven-sulfur cluster to hexakis-L-cysteinyl L-serinyl octairon heptasulfide." [PubMed:10525412, PubMed:12215645, PubMed:9063865, RESID:AA0300] comment: Cross-link 7; incidental to RESID:AA0141. synonym: "Cys6Ser-[8Fe7S]" EXACT PSI-MOD-label [] synonym: "hexakis-L-cysteinyl L-serinyl octairon heptasulfide" EXACT RESID-name [] synonym: "METAL Iron-sulfur (8Fe-7S)" EXACT UniProt-feature [] synonym: "nitrogenase P-cluster" EXACT RESID-alternate [] xref: DiffAvg: "663.12" xref: DiffFormula: "C 0 Fe 8 H -8 N 0 O 0 S 7" xref: DiffMono: "663.223042" xref: FormalCharge: "3-" xref: Formula: "C 21 Fe 8 H 27 N 7 O 8 S 13" xref: MassAvg: "1369.03" xref: MassMono: "1368.310179" xref: Origin: "C, C, C, C, C, C, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00306 name: residues isobaric at 113.084064 Da def: "Natural or modified residues with a mass of 113.084064 Da." [PubMed:10523135, RESID:AA0301] subset: PSI-MOD-slim synonym: "L-isoleucine or L-leucine" EXACT RESID-name [] synonym: "Xle" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 11 N 1 O 1" xref: MassAvg: "113.16" xref: MassMono: "113.084064" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da is_a: MOD:00624 ! residues isobaric at 113.0-113.1 Da [Term] id: MOD:00307 name: L-aspartimide def: "A protein modification that effectively cyclizes an L-asparagine residue to form a carboxyl-terminal L-aspartimide." [DeltaMass:18, PubMed:12771378, PubMed:2378679, PubMed:7662664, PubMed:7988548, PubMed:9309583, RESID:AA0302, UniMod:23#N] comment: From DeltaMass: Average Mass: -17 Average Mass Change:-17 References:Clarke, S., Lability of Aspargine and Aspartic Acid Residues in Protein and Peptides, in: Stability of Protein Pharmaceuticals : Chemical and Physical Paths of Protein Degradation, Part A (T.J. Ahern and M.C. Manning, eds.), 1992,Plenum Press, New York, pp.1-29Xie, M.; Vander Velde, D.; Morton, M.; Borchardt, R.T.; Schowen,R.L.: pH-Induced Change in the Rate-Determining Step for the Hydrolysis of the Asp/Asn-Derived Cyclic-Imide Intermediate in Protein Degradation. (1996) J. Am. Chem. Soc. 118: 8955-8956. synonym: "(3S)-3-amino-2,5-pyrrolidinedione" EXACT RESID-systematic [] synonym: "2-amino-butanimide" EXACT RESID-alternate [] synonym: "alpha-aminosuccinimide" EXACT RESID-alternate [] synonym: "ASI" EXACT RESID-alternate [] synonym: "Dehydrated" RELATED UniMod-interim [] synonym: "Dehydration" RELATED UniMod-description [] synonym: "L-2-aminosuccinimide" EXACT RESID-alternate [] synonym: "L-3-aminosuccinimide" RELATED RESID-misnomer [] synonym: "L-asparaginimide" EXACT RESID-alternate [] synonym: "L-aspartimide" EXACT RESID-name [] synonym: "Succinimide formation from asparagine" EXACT DeltaMass-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 4 H 5 N 2 O 2" xref: MassAvg: "113.10" xref: MassMono: "113.035102" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00601 ! cyclized residue is_a: MOD:00704 ! dehydrated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00308 name: L-glutamimide def: "A protein modification that effectively cyclizes an L-glutamine residue to form a carboxyl-terminal L-glutamimide." [PubMed:12771378, PubMed:14593103, RESID:AA0303, UniMod:23#Q] synonym: "(3S)-3-aminopiperidine-2,6-dione" EXACT RESID-systematic [] synonym: "2-aminopentanimide" EXACT RESID-alternate [] synonym: "3-amino-2,6-piperidinedione" EXACT RESID-alternate [] synonym: "alpha-aminoglutarimide" EXACT RESID-alternate [] synonym: "Dehydrated" RELATED UniMod-interim [] synonym: "Dehydration" RELATED UniMod-description [] synonym: "L-glutamimide" EXACT RESID-name [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 5 H 7 N 2 O 2" xref: MassAvg: "127.12" xref: MassMono: "127.050752" xref: Origin: "Q" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00601 ! cyclized residue is_a: MOD:00704 ! dehydrated residue is_a: MOD:00907 ! modified L-glutamine residue [Term] id: MOD:00309 name: L-beta-carboxyaspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to L-beta-carboxyaspartic acid." [OMSSA:47, PubMed:6390094, PubMed:7138832, PubMed:7457858, PubMed:8135347, RESID:AA0304, UniMod:299#D] comment: References to this modification as a gamma-carboxylation are in error [JSG]. synonym: "(2S)-2-aminoethane-1,1,2-tricarboxylic acid" EXACT RESID-systematic [] synonym: "2-amino-3-carboxybutanedioic acid" EXACT RESID-alternate [] synonym: "3-carboxy-L-aspartic acid" EXACT RESID-name [] synonym: "3-carboxyaspartic acid" EXACT RESID-alternate [] synonym: "3CbxAsp" EXACT PSI-MOD-label [] synonym: "beta-carboxyaspartic acid" EXACT RESID-alternate [] synonym: "Carboxy" RELATED PSI-MS-label [] synonym: "Carboxy" RELATED UniMod-interim [] synonym: "Carboxylation" RELATED UniMod-description [] synonym: "gammacarboxyld" EXACT OMSSA-label [] xref: DiffAvg: "44.01" xref: DiffFormula: "C 1 H 0 N 0 O 2" xref: DiffMono: "43.989829" xref: Formula: "C 5 H 5 N 1 O 5" xref: MassAvg: "159.10" xref: MassMono: "159.016772" xref: Origin: "D" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01152 ! carboxylated residue [Term] id: MOD:00310 name: N5-methyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to N5-methyl-L-arginine." [PubMed:11875433, PubMed:9792625, PubMed:9873020, RESID:AA0305] synonym: "(2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic acid" EXACT RESID-systematic [] synonym: "delta-N-methylarginine" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES N5-methylarginine" EXACT UniProt-feature [] synonym: "N5-carbamimidoyl-N5-methyl-L-ornithine" EXACT RESID-alternate [] synonym: "N5-methyl-L-arginine" EXACT RESID-name [] synonym: "N5-methylated L-arginine" EXACT PSI-MOD-alternate [] synonym: "N5Me1Arg" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 14 N 4 O 1" xref: MassAvg: "170.22" xref: MassMono: "170.116761" xref: Origin: "R" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00414 ! monomethylated L-arginine is_a: MOD:00602 ! N-methylated residue [Term] id: MOD:00311 name: L-cysteine coenzyme A disulfide def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine coenzyme A disulfide." [DeltaMass:0, PubMed:1734967, RESID:AA0306, UniMod:281#C] comment: DeltaMass gives no formula with mass as 454. synonym: "(2R)-2-amino-3-(2-((3-(((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino)-1-oxopropyl)amino)ethyl)dithio-propanoic acid 4'-ester with adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate)" EXACT RESID-systematic [] synonym: "coenzyme A L-cysteine mixed disulfide" EXACT RESID-alternate [] synonym: "CoenzymeA" RELATED PSI-MS-label [] synonym: "Cysteine modified Coenzyme A" RELATED UniMod-description [] synonym: "L-cysteine coenzyme A disulfide" EXACT RESID-name [] synonym: "SCoACys" EXACT PSI-MOD-label [] xref: DiffAvg: "765.52" xref: DiffFormula: "C 21 H 34 N 7 O 16 P 3 S 1" xref: DiffMono: "765.099559" xref: Formula: "C 24 H 39 N 8 O 17 P 3 S 2" xref: MassAvg: "868.66" xref: MassMono: "868.108744" xref: Origin: "C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01862 ! disulfide conjugated residue [Term] id: MOD:00312 name: S-myristoyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-myristoyl-L-cysteine." [PubMed:10026218, PubMed:10080938, PubMed:8824274, RESID:AA0307, UniMod:45#C] synonym: "(R)-2-amino-3-(tetradecanoylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "LIPID S-myristoyl cysteine" EXACT UniProt-feature [] synonym: "Myristoyl" RELATED PSI-MS-label [] synonym: "Myristoylation" RELATED UniMod-description [] synonym: "S-(C14:1 aliphatic acyl)cysteine" EXACT PSI-MOD-alternate [] synonym: "S-myristoyl-L-cysteine" EXACT RESID-name [] synonym: "S-myristoylated L-cysteine" EXACT PSI-MOD-alternate [] synonym: "SMyrCys" EXACT PSI-MOD-label [] synonym: "tetradecanoate cysteine thioester" EXACT RESID-alternate [] xref: DiffAvg: "210.36" xref: DiffFormula: "C 14 H 26 N 0 O 1 S 0" xref: DiffMono: "210.198365" xref: Formula: "C 17 H 31 N 1 O 2 S 1" xref: MassAvg: "313.50" xref: MassMono: "313.207550" xref: Origin: "C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00655 ! S-myristoylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00313 name: S-palmitoleyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-palmitoleyl-L-cysteine." [OMSSA:187, PubMed:8294460, RESID:AA0308, UniMod:431#C] synonym: "(R)-2-amino-3-((Z)-9-hexadecenoylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "cis-9-hexadecenoate cysteine thioester" EXACT RESID-alternate [] synonym: "mod187" EXACT OMSSA-label [] synonym: "Palmitoleyl" RELATED PSI-MS-label [] synonym: "palmitoleyl" RELATED UniMod-description [] synonym: "S-palmitoleyl-L-cysteine" EXACT RESID-name [] synonym: "S-palmitoleylated L-cysteine" EXACT PSI-MOD-alternate [] synonym: "SPamD1Cys" EXACT PSI-MOD-label [] xref: DiffAvg: "236.40" xref: DiffFormula: "C 16 H 28 N 0 O 1 S 0" xref: DiffMono: "236.214016" xref: Formula: "C 19 H 33 N 1 O 2 S 1" xref: MassAvg: "339.54" xref: MassMono: "339.223200" xref: Origin: "C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00672 ! S-acylated residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01423 ! palmitoleylated residue [Term] id: MOD:00314 name: glycine cholesterol ester def: "A protein modification that effectively converts a glycine residue to glycine cholesterol ester." [PubMed:11111088, PubMed:8824192, RESID:AA0309, UniMod:432#C-term] comment: Incidental to RESID:AA0060. UniMod origin corrected [JSG]. subset: PSI-MOD-slim synonym: "C-cholesterol" RELATED UniMod-interim [] synonym: "cholesterol ester" RELATED UniMod-description [] synonym: "cholesteryl glycinate" EXACT RESID-alternate [] synonym: "glycine cholest-5-en-3beta-ol ester" EXACT RESID-systematic [] synonym: "glycine cholesterol ester" EXACT RESID-name [] synonym: "hedgehog lipophilic adduct" EXACT RESID-alternate [] synonym: "LIPID Cholesterol glycine ester" EXACT UniProt-feature [] xref: DiffAvg: "368.65" xref: DiffFormula: "C 27 H 44 N 0 O 0" xref: DiffMono: "368.344301" xref: Formula: "C 29 H 48 N 1 O 2" xref: MassAvg: "442.71" xref: MassMono: "442.368505" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00315 name: pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide def: "A protein modification that effectively converts five L-cysteine residues, an L-histidine residue and a one-nickel four-iron five-sulfur cluster to pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide." [PubMed:11509720, PubMed:2550436, RESID:AA0310] comment: Cross-link 6. synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate [] synonym: "METAL Nickel-iron-sulfur (Ni-4Fe-5S)" EXACT UniProt-feature [] synonym: "METAL Nickel-iron-sulfur (Ni-4Fe-5S); via tele nitrogen" EXACT UniProt-feature [] synonym: "mu-1:2kappaS-sulfido-mu3-1:3:5kappaS-sulfido-mu3-2:3:4kappaS-sulfido-mu3-2:4:5kappaS-sulfido-mu3-3:4:5kappaS-sulfido-N1'-histidino-S-cysteinyl-1-iron-S-cysteinyl-2-nickel-3,4,5-tris-(S-cysteinyl iron)" EXACT RESID-systematic [] synonym: "Ni-4Fe-5S cluster" EXACT RESID-alternate [] synonym: "pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide" EXACT RESID-name [] xref: DiffAvg: "436.33" xref: DiffFormula: "C 0 Fe 4 H -6 N 0 Ni 1 O 0 S 5" xref: DiffMono: "435.488498" xref: Formula: "C 21 Fe 4 H 26 N 8 Ni 1 O 6 S 10" xref: MassAvg: "1089.16" xref: MassMono: "1087.593333" xref: Origin: "C, C, C, C, C, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00741 ! nickel containing modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00316 name: N4,N4-dimethyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4,N4-dimethyl-L-asparagine." [PubMed:12964758, PubMed:14570711, PubMed:8783012, RESID:AA0311, UniMod:36#N] synonym: "(2S)-2-amino-4-(dimethylamino)-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "2-amino-N4,N4-dimethylbutanediamic acid" EXACT RESID-alternate [] synonym: "beta-dimethylasparagine" RELATED RESID-misnomer [] synonym: "di-Methylation" RELATED UniMod-description [] synonym: "Dimethyl" RELATED PSI-MS-label [] synonym: "MOD_RES N4,N4-dimethylasparagine" EXACT UniProt-feature [] synonym: "N(gamma),N(gamma)-dimethylasparagine" EXACT RESID-alternate [] synonym: "N4,N4-dimethyl-L-asparagine" EXACT RESID-name [] synonym: "N4,N4-dimethylated L-asparagine" EXACT PSI-MOD-alternate [] synonym: "N4Me2Asn" EXACT PSI-MOD-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 6 H 10 N 2 O 2" xref: MassAvg: "142.16" xref: MassMono: "142.074228" xref: Origin: "N" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00429 ! dimethylated residue is_a: MOD:00602 ! N-methylated residue is_a: MOD:00673 ! methylated asparagine [Term] id: MOD:00317 name: N6-3,4-didehydroretinylidene-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-3,4-didehydroretinylidene-L-lysine." [PubMed:10717661, PubMed:3257009, PubMed:4056688, RESID:AA0312, UniMod:433#K] synonym: "(S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT RESID-systematic [] synonym: "3,4-didehydroretinylidene" RELATED UniMod-description [] synonym: "Didehydroretinylidene" RELATED PSI-MS-label [] synonym: "N6-(3,4-didehydroretinylidene)-L-lysine" EXACT RESID-name [] synonym: "N6-3-dehydroretinal-L-lysine" EXACT RESID-alternate [] synonym: "N6-3-dehydroretinyl-lysine" EXACT RESID-alternate [] xref: DiffAvg: "264.41" xref: DiffFormula: "C 20 H 24 N 0 O 0" xref: DiffMono: "264.187801" xref: Formula: "C 26 H 36 N 2 O 1" xref: MassAvg: "392.59" xref: MassMono: "392.282764" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00318 name: 4'-(S-L-cysteinyl)-L-tryptophyl quinone def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone." [PubMed:11555656, PubMed:11717396, RESID:AA0313] comment: Cross-link 2; secondary to RESID:AA0148. synonym: "(2R)-2-amino-3-[(3-[(2S)-2-amino-2-carboxyethyl]-6,7-dioxo-6,7-dihydro-1H-indol-4-yl)sulfanyl]propanoic acid" EXACT RESID-systematic [] synonym: "3-(2-amino-2-carboxyethyl)-4-[2-amino-2-carboxyethyl]sulfanyl-6,7-indolinedione" EXACT RESID-alternate [] synonym: "4'-(L-cystein-S-yl)-L-tryptophyl quinone" EXACT RESID-name [] synonym: "4-(S-cysteinyl)tryptophan-6,7-dione" EXACT RESID-alternate [] synonym: "CROSSLNK 4'-cysteinyl-tryptophylquinone (Cys-Trp)" EXACT UniProt-feature [] synonym: "CTQ" EXACT RESID-alternate [] synonym: "cysteine tryptophylquinone" EXACT RESID-alternate [] xref: DiffAvg: "27.97" xref: DiffFormula: "C 0 H -4 N 0 O 2 S 0" xref: DiffMono: "27.958529" xref: Formula: "C 14 H 11 N 3 O 4 S 1" xref: MassAvg: "317.32" xref: MassMono: "317.047027" xref: Origin: "C, W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00687 ! thioether crosslinked residues is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00319 name: 3-(S-L-cysteinyl)-L-aspartic acid def: "A protein modification that effectively cross-links an L-cysteine residue and an L-aspartic acid residue by a thioether bond to form 2-(S-L-cysteinyl)-L-aspartic acid." [PubMed:11555656, PubMed:11717396, RESID:AA0314] comment: Cross-link 2. synonym: "(2R,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanedioic acid" EXACT RESID-systematic [] synonym: "(2R,3S,6R)-2,6-diamino-3-carboxy-4-thiaheptanedioic acid" EXACT RESID-alternate [] synonym: "3-(L-cystein-S-yl)-L-aspartic acid" EXACT RESID-name [] synonym: "3-carboxy-L-lanthionine" EXACT RESID-alternate [] synonym: "CROSSLNK 3-cysteinyl-aspartic acid (Cys-Asp)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 7 H 8 N 2 O 4 S 1" xref: MassAvg: "216.21" xref: MassMono: "216.020478" xref: Origin: "C, D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01993 ! beta-carbon thioether crosslinked residues [Term] id: MOD:00320 name: 4-(S-L-cysteinyl)-L-glutamic acid def: "A protein modification that effectively cross-links an L-cysteine residue and an L-glutamic acid residue by a thioether bond to form 4-(S-L-cysteinyl)-L-glutamic acid." [ChEBI:20293, PubMed:11555656, PubMed:11717396, RESID:AA0315] comment: Cross-link 2. synonym: "(2S,3S,7R)-2,7-diamino-4-carboxy-5-thiaoctanedioic acid" EXACT RESID-alternate [] synonym: "(2S,4S)-2-amino-4-[(R)-2-amino-2-carboxyethyl]sulfanylpentanedioic acid" EXACT RESID-systematic [] synonym: "4-(L-cystein-S-yl)-L-glutamic acid" EXACT RESID-name [] synonym: "CROSSLNK 4-cysteinyl-glutamic acid (Cys-Glu)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 8 H 10 N 2 O 4 S 1" xref: MassAvg: "230.24" xref: MassMono: "230.036128" xref: Origin: "C, E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00687 ! thioether crosslinked residues is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00321 name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester def: "A protein modification that effectively converts an L-aspartic acid residue to cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester." [PubMed:11435437, PubMed:7949339, RESID:AA0316, UniMod:434#D] synonym: "(7Z,14Xi)-14-[(S)-3-amino-3-carboxy-propanoyl]oxy-10,13-dioxo-7-heptadecenoic acid" EXACT RESID-systematic [] synonym: "barley lipid transfer protein modification" EXACT RESID-alternate [] synonym: "CHDH" RELATED PSI-MS-label [] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester" EXACT RESID-name [] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic ester" RELATED UniMod-description [] synonym: "LIPID Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester" EXACT UniProt-feature [] xref: DiffAvg: "294.39" xref: DiffFormula: "C 17 H 26 N 0 O 4" xref: DiffMono: "294.183109" xref: Formula: "C 21 H 31 N 1 O 7" xref: MassAvg: "409.48" xref: MassMono: "409.210052" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00322 name: 1'-methyl-L-histidine def: "A protein modification that effectively converts an L-histidine residue to tele-methyl-L-histidine." [PubMed:10601317, PubMed:11474090, PubMed:11875433, PubMed:6692818, PubMed:8076, PubMed:8645219, RESID:AA0317] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "1'-methyl-L-histidine" EXACT RESID-name [] synonym: "3-methylhistidine" RELATED RESID-misnomer [] synonym: "4-methyl-histidine" RELATED RESID-misnomer [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES Tele-methylhistidine" EXACT UniProt-feature [] synonym: "N(epsilon)-methylhistidine" EXACT RESID-alternate [] synonym: "N(tau)-methylhistidine" EXACT RESID-alternate [] synonym: "NteleMeHis" EXACT PSI-MOD-label [] synonym: "tele-methylated L-histidine" EXACT PSI-MOD-alternate [] synonym: "tele-methylhistidine" EXACT RESID-alternate [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 9 N 3 O 1" xref: MassAvg: "151.17" xref: MassMono: "151.074562" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00724 ! N-methylated L-histidine [Term] id: MOD:00323 name: L-lysine methyl ester def: "A protein modification that effectively converts an L-lysine residue to L-lysine methyl ester." [PubMed:10973948, PubMed:11875433, RESID:AA0318, UniMod:34#C-term] subset: PSI-MOD-slim synonym: "2,6-diaminohexanoic methyl ester" EXACT RESID-alternate [] synonym: "alpha,epsilon-diaminocaproic methyl ester" EXACT RESID-alternate [] synonym: "L-lysine methyl ester" EXACT RESID-name [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "methyl (S)-2,6-diaminohexanoate" EXACT RESID-systematic [] synonym: "methyl esterified L-lysine" EXACT PSI-MOD-alternate [] synonym: "methyl L-lysinate" EXACT RESID-alternate [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES Lysine methyl ester" EXACT UniProt-feature [] synonym: "OMeLys" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 15 N 2 O 2" xref: MassAvg: "159.21" xref: MassMono: "159.113353" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01683 ! monomethylated L-lysine is_a: MOD:01689 ! alpha-carboxyl methylated residue [Term] id: MOD:00324 name: L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) def: "A protein modification that effectively converts an L-serine residue to L-serinyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:8658132, PubMed:8658134, RESID:AA0319] synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate [] synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-O3-serinyl-molybdenum oxide" EXACT RESID-systematic [] synonym: "L-serinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name [] xref: DiffAvg: "1588.01" xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 27 P 4 S 4" xref: DiffMono: "1588.980690" xref: Formula: "C 43 H 52 Mo 1 N 21 O 29 P 4 S 4" xref: MassAvg: "1675.09" xref: MassMono: "1676.012718" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00744 ! molybdenum pterin containing modification is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00325 name: L-beta-methylthioasparagine def: "A protein modification that effectively converts an L-asparagine residue to L-beta-methylthioasparagine." [RESID:AA0320, UniMod:39#N] comment: This modification was predicted for ribosomal protein S12 in Bacillus subtilis when the sequence in the original version of the genome was reported to have asparagine rather than aspartic acid at the position of the methylthioaspartic acid modification (see MOD:00237). Two groups independently confirmed that the genome sequence was incorrect. The sequence in the revised genome has aspartic acid at that position. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "(2R,3Xi)-2-amino-3-(methylsulfanyl)-4-butanediamic acid" EXACT RESID-systematic [] synonym: "2,4-diamino-3-(methylsulfanyl)-4-oxobutanoic acid" EXACT RESID-alternate [] synonym: "3-(methylthio)-L-asparagine" EXACT RESID-name [] synonym: "3-carboxamido-S-methyl-cysteine" EXACT RESID-alternate [] synonym: "beta-(methylthio)asparagine" EXACT RESID-alternate [] synonym: "Beta-methylthiolation" RELATED UniMod-description [] synonym: "Methylthio" RELATED UniMod-interim [] xref: DiffAvg: "46.09" xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1" xref: DiffMono: "45.987721" xref: Formula: "C 5 H 8 N 2 O 2 S 1" xref: MassAvg: "160.19" xref: MassMono: "160.030649" xref: Origin: "N" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01153 ! methylthiolated residue [Term] id: MOD:00326 name: L-pyrrolysine (Lys) def: "A protein modification that effectively converts an L-lysine residue to L-pyrrolysine (not known as a natural, post-translational modification process)." [PubMed:11435424, PubMed:12029131, PubMed:12029132, PubMed:15314242, PubMed:16096277, RESID:AA0321#LYS, UniMod:435#K] comment: This entry is for the artifactual formation of L-pyrrolysine from lysine. For encoded L-pyrrolysine, use MOD:01187 [JSG]. synonym: "(2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid" EXACT RESID-alternate [] synonym: "L-pyrrolysine" EXACT RESID-name [] synonym: "monomethylamine methyltransferase cofactor lysine adduct" EXACT RESID-alternate [] synonym: "N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine" EXACT RESID-alternate [] synonym: "NON_STD Pyrrolysine" EXACT UniProt-feature [] synonym: "Pyl(Lys)" EXACT PSI-MOD-label [] xref: DiffAvg: "109.13" xref: DiffFormula: "C 6 H 7 N 1 O 1" xref: DiffMono: "109.052764" xref: Formula: "C 12 H 19 N 3 O 2" xref: MassAvg: "237.30" xref: MassMono: "237.147727" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01187 ! L-pyrrolysine residue [Term] id: MOD:00327 name: 3-hydroxy-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to a 3-hydroxy-L-tryptophan." [PubMed:10024453, PubMed:11457355, RESID:AA0322] synonym: "(2S,3S)-2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "3-hydroxy-L-tryptophan" EXACT RESID-name [] synonym: "3-hydroxylated L-tryptophan" EXACT PSI-MOD-alternate [] synonym: "3-hydroxytryptophan" EXACT RESID-alternate [] synonym: "3HyTrp" EXACT PSI-MOD-label [] synonym: "beta-hydroxytryptophan" EXACT RESID-alternate [] synonym: "MOD_RES 3-hydroxytryptophan" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 11 H 10 N 2 O 2" xref: MassAvg: "202.21" xref: MassMono: "202.074228" xref: Origin: "W" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01622 ! monohydroxylated tryptophan [Term] id: MOD:00328 name: O4'-(phospho-3'-DNA)-L-tyrosine def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 3'-end of DNA through a phosphodiester bond to form O4'-(phospho-3'-DNA)-L-tyrosine." [PubMed:2211714, RESID:AA0323] synonym: "(S)-2-amino-3-[4-(3'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic [] synonym: "ACT_SITE O-(3'-phospho-DNA)-tyrosine intermediate" EXACT UniProt-feature [] synonym: "O4'-(phospho-3'-DNA)-L-tyrosine" EXACT RESID-name [] synonym: "O4'-L-tyrosine 3'-DNA phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 9 H 10 N 1 O 5 P 1" xref: MassAvg: "243.15" xref: MassMono: "243.029659" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00750 ! deoxyribonucleic acid linked residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00329 name: hydroxyheme-L-glutamate ester def: "A protein modification that effectively results from forming an adduct between a glutamic acid residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:11139583, PubMed:11821421, PubMed:11980497, RESID:AA0324, UniMod:436#E] synonym: "5-hydroxymethyl protoporphyrin IX 5-glutamate ester" EXACT RESID-alternate [] synonym: "[3-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-7,12-diethenyl-8,13,17-trimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] synonym: "BINDING Heme (covalent; via 1 link)" EXACT UniProt-feature [] synonym: "cytochrome P450 CYP4A family heme cofactor" EXACT RESID-alternate [] synonym: "Hydroxyheme" RELATED PSI-MS-label [] synonym: "hydroxyheme" RELATED UniMod-description [] synonym: "hydroxyheme-L-glutamate ester" EXACT RESID-name [] xref: DiffAvg: "614.48" xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4" xref: DiffMono: "614.161643" xref: Formula: "C 39 Fe 1 H 37 N 5 O 7" xref: MassAvg: "743.60" xref: MassMono: "743.204236" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00330 name: (phospho-5'-guanosine)-L-histidine def: "A protein modification that effectively converts an L-histidine residue to a (phospho-5'-guanosine)-L-histidine." [PubMed:10529169, PubMed:10869342, PubMed:7559521, RESID:AA0325, UniMod:413#H] synonym: "(2S)-2-amino-3-(1-(5'-adenosine phosphono)imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "1'-(phospho-5'-guanosine)-L-histidine" EXACT RESID-name [] synonym: "ACT_SITE GMP-histidine intermediate" EXACT UniProt-feature [] synonym: "L-histidine 5'-guanosine phosphoramidester" EXACT RESID-alternate [] synonym: "L-histidine monoanhydride with 5'-guanylic acid" EXACT RESID-alternate [] synonym: "N(tau)-5'-guanylic-L-histidine" EXACT RESID-alternate [] synonym: "N1'-guanylylated histidine" EXACT RESID-alternate [] synonym: "phospho-guanosine" RELATED UniMod-description [] synonym: "Phosphoguanosine" RELATED PSI-MS-label [] synonym: "tele-5'-guanylic-L-histidine" EXACT RESID-alternate [] xref: DiffAvg: "345.21" xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1" xref: DiffMono: "345.047434" xref: Formula: "C 16 H 19 N 8 O 8 P 1" xref: MassAvg: "482.35" xref: MassMono: "482.106346" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01163 ! guanylated residue [Term] id: MOD:00331 name: tetrakis-L-cysteinyl triiron tetrasulfide def: "A protein modification that effectively converts four L-cysteine residues and a three-iron four-sulfur cluster to tetrakis-L-cysteinyl triiron tetrasulfide." [PubMed:11592901, PubMed:11941493, PubMed:2511202, PubMed:6094558, RESID:AA0326] comment: Cross-link 4. synonym: "bis[bis-L-cysteinyl iron disulfido]iron" EXACT RESID-alternate [] synonym: "di-mu-1:2kappaS-sulfido di-mu-2:3kappaS-sulfido iron bis(bis-S-cysteinyliron)" EXACT RESID-systematic [] synonym: "tetra-mu-sulfido tetrakis-S-L-cysteinyl triiron" EXACT RESID-alternate [] synonym: "tetrakis-L-cysteinyl linear [3Fe-4S] cluster" EXACT RESID-alternate [] synonym: "tetrakis-L-cysteinyl triiron tetrasulfide" EXACT RESID-name [] synonym: "tetrakis-L-cysteinyl triiron tetrasulfide D2 cluster" EXACT RESID-alternate [] xref: DiffAvg: "291.74" xref: DiffFormula: "C 0 Fe 3 H -4 N 0 O 0 S 4" xref: DiffMono: "291.663442" xref: FormalCharge: "3-" xref: Formula: "C 12 Fe 3 H 16 N 4 O 4 S 8" xref: MassAvg: "704.30" xref: MassMono: "703.700181" xref: Origin: "C, C, C, C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00332 name: omega-N-glucosyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to N4-glucosyl-arginine." [PubMed:15279557, PubMed:8521968, PubMed:9536051, RESID:AA0327, UniMod:41#R] synonym: "(2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid" EXACT RESID-systematic [] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] synonym: "NG-beta-D-glucosylarginine" EXACT RESID-alternate [] synonym: "omega-N-(beta-D-glucosyl)-L-arginine" EXACT RESID-alternate [] synonym: "omega-N-glucosyl-L-arginine" EXACT RESID-name [] synonym: "omega-N-glycosyl-L-arginine" EXACT RESID-alternate [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 12 H 22 N 4 O 6" xref: MassAvg: "318.33" xref: MassMono: "318.153934" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00433 ! glucosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:01980 ! omega-N-glycosyl-L-arginine [Term] id: MOD:00333 name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine def: "A protein modification that effectively converts an L-asparagine residue to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine." [PubMed:7559516, PubMed:7835418, PubMed:8183363, RESID:AA0328, UniMod:437#C-term] comment: UniMod origin shown as C-term [JSG]. synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine" EXACT RESID-name [] synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5-adenosine" RELATED UniMod-description [] synonym: "5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]adenosine" EXACT RESID-systematic [] synonym: "9-(5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]-beta-D-ribofuranosyl)adenine" EXACT RESID-alternate [] synonym: "C-Asn-deriv" RELATED UniMod-interim [] synonym: "microcin C7 asparagine modification" EXACT RESID-alternate [] synonym: "MOD_RES Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide" EXACT UniProt-feature [] synonym: "N-(aspart-1-yl)-O-(3-aminopropyl)-O-(5'-adenosyl)phosphoramide" EXACT RESID-alternate [] xref: DiffAvg: "386.30" xref: DiffFormula: "C 13 H 19 N 6 O 6 P 1" xref: DiffMono: "386.110369" xref: Formula: "C 17 H 26 N 8 O 9 P 1" xref: MassAvg: "517.42" xref: MassMono: "517.156036" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00701 ! nucleotide or nucleic acid modified residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00334 name: 1'-heme-L-histidine def: "A protein modification that effectively results from forming an adduct between the tele nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12033922, PubMed:12121092, RESID:AA0329, UniMod:390#H] synonym: "(S)-[7-ethenyl-12-[1-((2-amino-2-carboxyethyl)-1H-imidazol-1-yl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic [] synonym: "1'-heme-L-histidine" EXACT RESID-name [] synonym: "2-[1-(N1'-histidyl)ethyl]protoporphyrin IX" EXACT RESID-alternate [] synonym: "BINDING Heme (covalent; via tele nitrogen)" EXACT UniProt-feature [] synonym: "Heme" RELATED PSI-MS-label [] synonym: "heme" RELATED UniMod-description [] synonym: "N(epsilon)-histidyl heme" EXACT RESID-alternate [] synonym: "N(tau)-histidyl heme" EXACT RESID-alternate [] synonym: "N1'-histidyl heme" EXACT RESID-alternate [] synonym: "tele-histidyl heme" EXACT RESID-alternate [] xref: DiffAvg: "616.50" xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4" xref: DiffMono: "616.177293" xref: Formula: "C 40 Fe 1 H 39 N 7 O 5" xref: MassAvg: "753.64" xref: MassMono: "753.236205" xref: Origin: "H" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00699 ! porphyrin modified residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00335 name: (2S,3S,2'R)-3-methyllanthionine sulfoxide def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine sulfoxide." [PubMed:7737178, PubMed:9219543, RESID:AA0330] comment: Cross-link 2. synonym: "(2S,3S,4Xi,6R)-2,6-diamino-3-methyl-4-oxo-4-thiaheptanedioic acid" EXACT RESID-alternate [] synonym: "(2S,3S,SXi)-2-amino-3-([(R)-2-amino-2-carboxyethyl]sulfinyl)butanoic acid" EXACT RESID-systematic [] synonym: "3-methyl-L-lanthionine S-oxide" EXACT RESID-alternate [] synonym: "3-methyl-L-lanthionine sulfoxide" EXACT RESID-name [] synonym: "CROSSLNK Beta-methyllanthionine sulfoxide (Thr-Cys)" EXACT UniProt-feature [] synonym: "S-oxy-3-methyllanthionine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 7 H 10 N 2 O 3 S 1" xref: MassAvg: "202.23" xref: MassMono: "202.041213" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01993 ! beta-carbon thioether crosslinked residues relationship: has_functional_parent MOD:01981 ! 3-methyllanthionine [Term] id: MOD:00336 name: tris-L-cysteinyl L-aspartato diiron disulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-aspartato diiron disulfide." [PubMed:10968624, PubMed:1312028, PubMed:7947772, RESID:AA0331] comment: Cross-link 4. synonym: "di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-O4-aspartatoiron)" EXACT RESID-systematic [] synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] synonym: "tris-L-cysteinyl L-aspartato diiron disulfide" EXACT RESID-name [] xref: DiffAvg: "171.78" xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2" xref: DiffMono: "171.783814" xref: FormalCharge: "2-" xref: Formula: "C 13 Fe 2 H 16 N 4 O 6 S 5" xref: MassAvg: "596.28" xref: MassMono: "595.838311" xref: Origin: "C, C, C, D" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00337 name: S-carbamoyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-carbamoyl-L-cysteine." [PubMed:12586941, PubMed:240389, RESID:AA0332, UniMod:5#C] synonym: "(R)-2-amino-3-(carbamoylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(aminocarbonyl)sulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-(aminocarbonyl)thiopropanoic acid" EXACT RESID-alternate [] synonym: "alpha-amino-beta-carbamylthiopropionic acid" EXACT RESID-alternate [] synonym: "beta-carbamylthioalanine" EXACT RESID-alternate [] synonym: "MOD_RES S-carbamoylcysteine" EXACT UniProt-feature [] synonym: "S-(aminocarbonyl)cysteine" EXACT RESID-alternate [] synonym: "S-carbamoyl-L-cysteine" EXACT RESID-name [] synonym: "S-carbamoylcysteine" EXACT RESID-alternate [] synonym: "S-carbamylcysteine" EXACT RESID-alternate [] synonym: "S-cysteinyl carbamate ester" EXACT RESID-alternate [] synonym: "SCbmCys" EXACT PSI-MOD-label [] xref: DiffAvg: "43.02" xref: DiffFormula: "C 1 H 1 N 1 O 1 S 0" xref: DiffMono: "43.005814" xref: Formula: "C 4 H 6 N 2 O 2 S 1" xref: MassAvg: "146.16" xref: MassMono: "146.014998" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00398 ! carbamoylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00338 name: S-cyano-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-cyano-L-cysteine." [PubMed:12586941, PubMed:4808702, RESID:AA0333, UniMod:438#C] synonym: "(2R)-2-amino-3-thiocyanatopropanoic acid" EXACT RESID-systematic [] synonym: "alpha-amino-beta-thiocyanatopropionic acid" EXACT RESID-alternate [] synonym: "beta-thiocyanatoalanine" EXACT RESID-alternate [] synonym: "Cyano" RELATED PSI-MS-label [] synonym: "cyano" RELATED UniMod-description [] synonym: "MOD_RES S-cyanocysteine" EXACT UniProt-feature [] synonym: "S-cyano-L-cysteine" EXACT RESID-name [] synonym: "S-cyanocysteine" EXACT RESID-alternate [] synonym: "serine thiocyanic acid ester" EXACT RESID-alternate [] xref: DiffAvg: "25.01" xref: DiffFormula: "C 1 H -1 N 1 O 0 S 0" xref: DiffMono: "24.995249" xref: Formula: "C 4 H 4 N 2 O 1 S 1" xref: MassAvg: "128.15" xref: MassMono: "128.004434" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00893 ! residues isobaric at 128.0-128.1 is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00339 name: L-cysteinyl hydrogenase diiron subcluster def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl hydrogenase diiron subcluster." [PubMed:10694885, PubMed:9836629, RESID:AA0334, UniMod:439#C] comment: incidental to RESID:AA0140. synonym: "1,7-biscarbonyl-1-(cystein-S-yl)-8-oxo-4-aza-2lambda(3),6 lambda(3)-dithia-1,7-diferratricyclo[4.2.0.0(2,7)]octane-1,7-dicarbonitrile" EXACT RESID-alternate [] synonym: "Diironsubcluster" RELATED PSI-MS-label [] synonym: "hydrogenase diiron subcluster" RELATED UniMod-description [] synonym: "L-cysteinyl hydrogenase diiron subcluster" EXACT RESID-name [] synonym: "METAL Diiron subcluster" EXACT UniProt-feature [] synonym: "mu-carbonyl-dicarbonyl-1kappaC,2kappaC-dicyanido-1kappaC,2kappaC-cysteinato-1kS-1,2-azadimethanthiol-1kS,2kS'-diiron" EXACT RESID-systematic [] xref: DiffAvg: "342.87" xref: DiffFormula: "C 5 Fe 2 H -1 N 2 O 5 S 2" xref: DiffMono: "342.786913" xref: Formula: "C 8 Fe 2 H 4 N 3 O 6 S 3" xref: MassAvg: "446.01" xref: MassMono: "445.796098" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00738 ! iron containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00340 name: S-amidino-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-amidino-L-cysteine." [PubMed:9148748, RESID:AA0335, UniMod:440#C] synonym: "(2R)-2-amino-3-(carbamimidoylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-amidinosulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-amidinothiopropanoic acid" EXACT RESID-alternate [] synonym: "ACT_SITE Amidino-cysteine intermediate" EXACT UniProt-feature [] synonym: "alpha-amino-beta-amidinothiopropionic acid" EXACT RESID-alternate [] synonym: "Amidino" RELATED PSI-MS-label [] synonym: "amidino" RELATED UniMod-description [] synonym: "beta-(S-isothiourea)alanine" EXACT RESID-alternate [] synonym: "beta-amidinothioalanine" EXACT RESID-alternate [] synonym: "S-amidino-L-cysteine" EXACT RESID-name [] synonym: "S-amidinocysteine" EXACT RESID-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 1 H 2 N 2 O 0 S 0" xref: DiffMono: "42.021798" xref: Formula: "C 4 H 7 N 3 O 1 S 1" xref: MassAvg: "145.18" xref: MassMono: "145.030983" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00341 name: N-methyl-L-isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to N-methyl-L-isoleucine." [PubMed:11875433, RESID:AA0336] comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. synonym: "(2S,3S)-2-methylamino-3-methylpentanoic acid" EXACT RESID-systematic [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES N-methylisoleucine" EXACT UniProt-feature [] synonym: "N-methyl-L-isoleucine" EXACT RESID-name [] synonym: "N-methylated L-isoleucine" EXACT PSI-MOD-alternate [] synonym: "N-methylisoleucine" EXACT RESID-alternate [] synonym: "NMe1Ile" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 13 N 1 O 1" xref: MassAvg: "127.19" xref: MassMono: "127.099714" xref: Origin: "I" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00715 ! methylated isoleucine is_a: MOD:01680 ! alpha-amino monomethylated residue [Term] id: MOD:00342 name: N-methyl-L-leucine def: "A protein modification that effectively converts an L-leucine residue to N-methyl-L-leucine." [PubMed:11875433, RESID:AA0337] comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. synonym: "(S)-2-methylamino-4-methylpentanoic acid" EXACT RESID-systematic [] synonym: "2-(methylamino)-4-methyl-valeric acid" EXACT RESID-alternate [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "MOD_RES N-methylleucine" EXACT UniProt-feature [] synonym: "N-methyl-L-leucine" EXACT RESID-name [] synonym: "N-methylated L-leucine" EXACT PSI-MOD-alternate [] synonym: "N-methylleucine" EXACT RESID-alternate [] synonym: "NMe1Leu" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 13 N 1 O 1" xref: MassAvg: "127.19" xref: MassMono: "127.099714" xref: Origin: "L" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01680 ! alpha-amino monomethylated residue is_a: MOD:01808 ! N-methylated leucine [Term] id: MOD:00343 name: N-methyl-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to N-methyl-L-tyrosine." [DeltaMass:0, RESID:AA0338] comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. synonym: "(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid" EXACT RESID-systematic [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "MOD_RES N-methyltyrosine" EXACT UniProt-feature [] synonym: "N-methyl Tyrosinyl" EXACT DeltaMass-label [] synonym: "N-methyl-L-tyrosine" EXACT RESID-name [] synonym: "N-methylated L-tyrosine" EXACT PSI-MOD-alternate [] synonym: "N-methyltyrosine" EXACT RESID-alternate [] synonym: "NMe1Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 10 H 11 N 1 O 2" xref: MassAvg: "177.20" xref: MassMono: "177.078979" xref: Origin: "Y" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00718 ! methylated tyrosine is_a: MOD:01680 ! alpha-amino monomethylated residue [Term] id: MOD:00344 name: N-palmitoylglycine def: "A protein modification that effectively converts a glycine residue to N-palmitoylglycine." [PubMed:12574119, RESID:AA0339] comment: incidental to RESID:AA0060 subset: PSI-MOD-slim synonym: "(hexadecanamido)acetic acid" EXACT RESID-alternate [] synonym: "(hexadecanoylamino)acetic acid" EXACT RESID-alternate [] synonym: "(hexadecanoylamino)ethanoic acid" EXACT RESID-systematic [] synonym: "LIPID N-palmitoyl glycine" EXACT UniProt-feature [] synonym: "N-(1-oxohexadecyl)glycine" EXACT RESID-alternate [] synonym: "N-palmitoyl-glycine" EXACT RESID-name [] synonym: "N-palmitoylated glycine" EXACT PSI-MOD-alternate [] synonym: "NPamGly" EXACT PSI-MOD-label [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" xref: DiffMono: "238.229666" xref: Formula: "C 18 H 34 N 1 O 2" xref: MassAvg: "296.47" xref: MassMono: "296.258954" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01685 ! alpha-amino palmitoylated residue [Term] id: MOD:00345 name: 2-(S-L-cysteinyl)-L-phenylalanine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-phenylalanine." [PubMed:12696888, PubMed:3936839, RESID:AA0340] comment: Cross-link 2. synonym: "(2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid" EXACT RESID-systematic [] synonym: "(2R,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid" EXACT RESID-alternate [] synonym: "2-(L-cystein-S-yl)-L-phenylalanine" EXACT RESID-name [] synonym: "alpha-(L-cystein-S-yl)-L-phenylalanine" EXACT RESID-alternate [] synonym: "CROSSLNK 2-cysteinyl-L-phenylalanine (Cys-Phe)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 12 H 12 N 2 O 2 S 1" xref: MassAvg: "248.30" xref: MassMono: "248.061949" xref: Origin: "C, F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:00346 name: 2-(S-L-cysteinyl)-D-phenylalanine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-phenylalanine." [PubMed:12696888, PubMed:3936839, RESID:AA0341] comment: Cross-link 2. synonym: "(2S)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid" EXACT RESID-systematic [] synonym: "(2S,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid" EXACT RESID-alternate [] synonym: "2-(L-cystein-S-yl)-D-phenylalanine" EXACT RESID-name [] synonym: "alpha-(L-cystein-S-yl)-D-phenylalanine" EXACT RESID-alternate [] synonym: "CROSSLNK 2-cysteinyl-D-phenylalanine (Cys-Phe)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 12 H 12 N 2 O 2 S 1" xref: MassAvg: "248.30" xref: MassMono: "248.061949" xref: Origin: "C, F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:00347 name: 2-(S-L-cysteinyl)-D-allo-threonine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-allo-threonine." [PubMed:12696888, PubMed:3936839, RESID:AA0342] comment: Cross-link 2. synonym: "(2R,5S,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid" EXACT RESID-alternate [] synonym: "(2S,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic [] synonym: "2-(L-cystein-S-yl)-D-allo-threonine" EXACT RESID-name [] synonym: "alpha-(L-cystein-S-yl)-D-allo-threonine" EXACT RESID-alternate [] synonym: "CROSSLNK 2-cysteinyl-D-allo-threonine (Cys-Thr)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 7 H 10 N 2 O 3 S 1" xref: MassAvg: "202.23" xref: MassMono: "202.041213" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:00348 name: N-carbamoyl-L-alanine def: "A protein modification that effectively converts an L-alanine residue to N-carbamoyl-L-alanine." [PubMed:12203680, RESID:AA0343] synonym: "(S)-2-(carbamoylamino)propanoic acid" EXACT RESID-systematic [] synonym: "2-ureidopropanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N-carbamoylalanine" EXACT UniProt-feature [] synonym: "N-carbamoyl-L-alanine" EXACT RESID-name [] synonym: "N-carbamylalanine" EXACT RESID-alternate [] synonym: "N2CbmAla" EXACT PSI-MOD-label [] xref: DiffAvg: "43.02" xref: DiffFormula: "C 1 H 1 N 1 O 1" xref: DiffMono: "43.005814" xref: Formula: "C 4 H 7 N 2 O 2" xref: MassAvg: "115.11" xref: MassMono: "115.050752" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:01679 ! alpha-aminocarbamoylated residue [Term] id: MOD:00349 name: 4-amino-3-isothiazolidinone-L-serine def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form 4-amino-3-isothiazolidinone-L-serine." [PubMed:12802338, PubMed:12802339, RESID:AA0344] comment: Cross-link 2. synonym: "(2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-hydroxypropanoic acid" EXACT RESID-systematic [] synonym: "2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-hydroxy-propanoic acid" EXACT RESID-alternate [] synonym: "4-amino-3-isothiazolidinone-L-serine" EXACT RESID-alternate [] synonym: "CROSSLNK N,N-(cysteine-1,S-diyl)serine (Cys-Ser)" EXACT UniProt-feature [] synonym: "N,N-(L-cysteine-1,S-diyl)-L-serine" EXACT RESID-name [] synonym: "serine-cysteine sulfenyl amide cross-link" EXACT RESID-alternate [] synonym: "serine-cysteine sulphenyl amide cross-link" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 6 H 8 N 2 O 3 S 1" xref: MassAvg: "188.20" xref: MassMono: "188.025563" xref: Origin: "C, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01861 ! isothiazolidinone ring crosslinked residues [Term] id: MOD:00350 name: L-threonyl-pentaglycyl-murein peptidoglycan def: "A protein modification that effectively attaches an L-threonine residue to murein peptidoglycan by a pentaglycine linker peptide." [PubMed:10754567, PubMed:1638631, RESID:AA0345] synonym: "(2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(threonyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine" EXACT RESID-alternate [] synonym: "L-threonyl-pentaglycyl-murein peptidoglycan" EXACT RESID-name [] synonym: "MOD_RES Pentaglycyl murein peptidoglycan amidated threonine" EXACT UniProt-feature [] xref: DiffAvg: "268.25" xref: DiffFormula: "C 10 H 14 N 5 O 4" xref: DiffMono: "268.104579" xref: Formula: "C 14 H 22 N 6 O 7" xref: MassAvg: "386.37" xref: MassMono: "386.154997" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01159 ! peptidoglycanated residue [Term] id: MOD:00351 name: N-glycyl-1-(phosphatidyl)ethanolamine def: "A protein modification that effectively converts a glycine residue to N-glycyl-1-(phosphatidyl)ethanolamine." [PubMed:11100732, RESID:AA0346] synonym: "(R)-1-hexadecanoyloxy-2-((Z)-9-octadecenoyloxy)-3-[2-(aminoacetylamino)ethyloxyphospho]propane" EXACT RESID-systematic [] synonym: "LIPID Phosphatidylethanolamine amidated glycine" EXACT UniProt-feature [] synonym: "N-glycyl-1-(phosphatidyl)ethanolamine" EXACT RESID-name [] synonym: "N-glycyl-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine" EXACT RESID-alternate [] xref: DiffAvg: "699.99" xref: DiffFormula: "C 39 H 74 N 1 O 7 P 1" xref: DiffMono: "699.520290" xref: Formula: "C 41 H 78 N 2 O 9 P 1" xref: MassAvg: "774.05" xref: MassMono: "773.544494" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00352 name: L-glutamyl 5-omega-hydroxyceramide ester def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-omega-hydroxyceramide ester." [PubMed:10411887, PubMed:9651377, RESID:AA0347] synonym: "(S)-2-amino-5-[30-((2S,3R,4E)-1,3-dihydroxyicos-4-en-2-ylamino)-30-oxotriacontan-1-yloxy]-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "2-[30-(isoglutamyloxy)triacontanoyl]icosasphingosine" EXACT RESID-alternate [] synonym: "L-glutamyl 5-omega-hydroxyceramide ester" EXACT RESID-name [] synonym: "LIPID Omega-hydroxyceramide glutamate ester" EXACT UniProt-feature [] xref: DiffAvg: "761.31" xref: DiffFormula: "C 50 H 96 N 0 O 4" xref: DiffMono: "760.730862" xref: Formula: "C 55 H 104 N 2 O 6" xref: MassAvg: "889.44" xref: MassMono: "888.789439" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00353 name: S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium def: "A protein modification that effectively cross-links an L-tryptophan residue with an L-tyrosine residue by a carbon-carbon bond, and cross-links the L-tyrosine residue to an L-methionine residue by a thioether bond to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [PubMed:12172540, PubMed:16285713, RESID:AA0348] comment: Cross-link 3. synonym: "5'-(6'-tryptophyl)-tyrosin-3'-yl-methionin-S-ium" EXACT RESID-alternate [] synonym: "S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium" EXACT RESID-name [] xref: DiffAvg: "-3.02" xref: DiffFormula: "C 0 H -3 N 0 O 0 S 0" xref: DiffMono: "-3.024024" xref: FormalCharge: "1+" xref: Formula: "C 25 H 25 N 4 O 4 S 1" xref: MassAvg: "477.56" xref: MassMono: "477.159103" xref: Origin: "M, W, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:00918 ! modified L-tryptophan residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00354 name: O-(riboflavin phosphoryl)-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-(riboflavin phosphoryl)-L-threonine." [PubMed:10587447, PubMed:11163785, PubMed:11248234, RESID:AA0349, UniMod:442#T] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)butanoic acid" EXACT RESID-systematic [] synonym: "FMN" RELATED PSI-MS-label [] synonym: "MOD_RES FMN phosphoryl threonine" EXACT UniProt-feature [] synonym: "O-(riboflavin phosphoryl)-L-threonine" EXACT RESID-name [] synonym: "O3-(riboflavin phosphoryl)" RELATED UniMod-description [] synonym: "O3-threonyl flavin mononucleotide" EXACT RESID-alternate [] synonym: "O3-threonyl FMN" EXACT RESID-alternate [] synonym: "OFMNThr" EXACT PSI-MOD-label [] xref: DiffAvg: "438.33" xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1" xref: DiffMono: "438.094050" xref: Formula: "C 21 H 26 N 5 O 10 P 1" xref: MassAvg: "539.44" xref: MassMono: "539.141729" xref: Origin: "T" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01164 ! riboflavin-phosphoryl [Term] id: MOD:00355 name: O-(riboflavin phosphoryl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(riboflavin phosphoryl)-L-serine." [RESID:AA0350, UniMod:442#S] subset: PSI-MOD-slim synonym: "(R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)propanoic acid" EXACT RESID-systematic [] synonym: "FMN" RELATED PSI-MS-label [] synonym: "MOD_RES FMN phosphoryl serine" EXACT UniProt-feature [] synonym: "O-(riboflavin phosphoryl)-L-serine" EXACT RESID-name [] synonym: "O3-(riboflavin phosphoryl)" RELATED UniMod-description [] synonym: "O3-seryl flavin mononucleotide" EXACT RESID-alternate [] synonym: "O3-seryl FMN" EXACT RESID-alternate [] synonym: "OFMNSer" EXACT PSI-MOD-label [] xref: DiffAvg: "438.33" xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1" xref: DiffMono: "438.094050" xref: Formula: "C 20 H 24 N 5 O 10 P 1" xref: MassAvg: "525.41" xref: MassMono: "525.126079" xref: Origin: "S" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01164 ! riboflavin-phosphoryl [Term] id: MOD:00356 name: S-(4a-FMN)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(4a-FMN)-L-cysteine." [PubMed:12668455, PubMed:12846567, PubMed:7692961, RESID:AA0351, UniMod:443#C] subset: PSI-MOD-slim synonym: "(R)-2-amino-3-(4a-riboflavin 5'-dihydrogen phosphate)sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "4a-(S-cysteinyl)flavin mononucleotide" EXACT RESID-alternate [] synonym: "4a-(S-cysteinyl)FMN" EXACT RESID-alternate [] synonym: "FMNC" RELATED PSI-MS-label [] synonym: "MOD_RES S-4a-FMN cysteine" EXACT UniProt-feature [] synonym: "S-(4a-FMN)" RELATED UniMod-description [] synonym: "S-(4a-FMN)-L-cysteine" EXACT RESID-name [] synonym: "S4aFMNCys" EXACT PSI-MOD-label [] xref: DiffAvg: "456.35" xref: DiffFormula: "C 17 H 21 N 4 O 9 P 1 S 0" xref: DiffMono: "456.104615" xref: Formula: "C 20 H 26 N 5 O 10 P 1 S 1" xref: MassAvg: "559.49" xref: MassMono: "559.113800" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00896 ! FMN modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00357 name: 1'-(8alpha-FMN)-L-histidine def: "A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FMN)-L-histidine." [PubMed:11902668, PubMed:8611516, RESID:AA0352, UniMod:409#H] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-(1-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "1'-(8alpha-FMN)-L-histidine" EXACT RESID-name [] synonym: "8alpha-(N(epsilon)-histidyl)FMN" EXACT RESID-alternate [] synonym: "8alpha-(N1'-histidyl)FMN" EXACT RESID-alternate [] synonym: "flavin mononucleotide" RELATED UniMod-description [] synonym: "FMNH" RELATED PSI-MS-label [] synonym: "MOD_RES Tele-8alpha-FMN histidine" EXACT UniProt-feature [] synonym: "N(tau)-(8alpha-FMN)-histidine" EXACT RESID-alternate [] synonym: "Ntele8aFMNHis" EXACT PSI-MOD-label [] synonym: "tele-(8alpha-FMN)-histidine" EXACT RESID-alternate [] xref: DiffAvg: "454.33" xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1" xref: DiffMono: "454.088965" xref: Formula: "C 23 H 26 N 7 O 10 P 1" xref: MassAvg: "591.47" xref: MassMono: "591.147877" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00896 ! FMN modified residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00358 name: 3'-(8alpha-FMN)-L-histidine def: "A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FMN)-L-histidine." [PubMed:12417325, RESID:AA0353, UniMod:409#H] comment: In a later publication, PubMed:19438211, the authors changed the enzyme activity, the connection from a histidine nitrogen to a cysteine sulfur, and the identity of the flavin from FMN to FAD. They now believe the modification is S-(8alpha-FAD)-L-cysteine, see MOD:00152. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. subset: PSI-MOD-slim synonym: "(S)-2-amino-3-(3-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "3'-(8alpha-FMN)-L-histidine" EXACT RESID-name [] synonym: "8alpha-(N(delta)-histidyl)FMN" EXACT RESID-alternate [] synonym: "8alpha-(N3'-histidyl)FMN" EXACT RESID-alternate [] synonym: "flavin mononucleotide" RELATED UniMod-description [] synonym: "FMNH" RELATED PSI-MS-label [] synonym: "N(pi)-(8alpha-FMN)-histidine" EXACT RESID-alternate [] synonym: "Npros8aFMNHis" EXACT PSI-MOD-label [] synonym: "pros-(8alpha-FMN)-histidine" EXACT RESID-alternate [] xref: DiffAvg: "454.33" xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1" xref: DiffMono: "454.088965" xref: Formula: "C 23 H 26 N 7 O 10 P 1" xref: MassAvg: "591.47" xref: MassMono: "591.147877" xref: Origin: "H" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00896 ! FMN modified residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00359 name: N2-acetyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to N2-acetyl-L-arginine." [PubMed:12883043, PubMed:1894641, RESID:AA0354] synonym: "(S)-2-acetamido-5-carbamimidamidopentanoic acid" EXACT RESID-systematic [] synonym: "2-acetamido-5-guanidinopentanoic acid" EXACT RESID-alternate [] synonym: "2-acetylamino-5-guanidinopentanoic acid" EXACT RESID-alternate [] synonym: "AcArg" EXACT PSI-MOD-label [] synonym: "acetylarginine" EXACT RESID-alternate [] synonym: "alpha-acetylamino-delta-guanidinovaleric acid" EXACT RESID-alternate [] synonym: "MOD_RES N2-acetylarginine" EXACT UniProt-feature [] synonym: "N(alpha)-acetylarginine" EXACT RESID-alternate [] synonym: "N2-acetyl-L-arginine" EXACT RESID-name [] synonym: "N2-acetylated L-arginine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 8 H 15 N 4 O 2" xref: MassAvg: "199.23" xref: MassMono: "199.119501" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00360 name: L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide." [PubMed:12475995, RESID:AA0355, UniMod:444#C] synonym: "[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with cytosine)methyl-6-oxo-3,4-dimercapto-pteridino[6,7-5,6]pyranoato-S3,S4]-cysteinyl-S-copper-mu-sulfido-molybdenum hydroxide oxide" EXACT RESID-systematic [] synonym: "copper sulfido molybdopterin cytosine dinuncleotide" RELATED UniMod-description [] synonym: "CuSMo" RELATED PSI-MS-label [] synonym: "cysteinyl copper mu-sulfido Mo-pterin cytosine dinucleotide" EXACT RESID-alternate [] synonym: "L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide" EXACT RESID-name [] xref: DiffAvg: "922.07" xref: DiffFormula: "C 19 Cu 1 H 24 Mo 1 N 8 O 15 P 2 S 3" xref: DiffMono: "922.834854" xref: Formula: "C 22 Cu 1 H 29 Mo 1 N 9 O 16 P 2 S 4" xref: MassAvg: "1025.20" xref: MassMono: "1025.844039" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00742 ! copper containing modified residue is_a: MOD:00744 ! molybdenum pterin containing modification is_a: MOD:00860 ! sulfur containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00361 name: tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide def: "A protein modification that effectively converts three L-cysteine residues, an S-adenosylmethionine and a four-iron four-sulfur cluster to tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [PubMed:11222759, PubMed:14704425, RESID:AA0356] comment: Cross-link 3. synonym: "METAL Iron-sulfur (4Fe-4S-S-AdoMet)" EXACT UniProt-feature [] synonym: "tetra-mu3-sulfido(S-adenosylmethion-N,O-diyliron)tris(S-cysteinyliron)" EXACT RESID-systematic [] synonym: "tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide" EXACT RESID-name [] xref: DiffAvg: "747.03" xref: DiffFormula: "C 15 Fe 4 H 19 N 6 O 5 S 5" xref: DiffMono: "746.742346" xref: FormalCharge: "1-" xref: Formula: "C 24 Fe 4 H 34 N 9 O 8 S 8" xref: MassAvg: "1056.45" xref: MassMono: "1055.769901" xref: Origin: "C, C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00362 name: tris-L-cysteinyl L-arginyl diiron disulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-arginine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-arginyl diiron disulfide." [PubMed:14704425, RESID:AA0357] comment: Cross-link 4. synonym: "di-mu-sulfido(N(eta1)-arginyl-S-cysteinyliron)(bis-S-cysteinyliron)" EXACT RESID-systematic [] synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] synonym: "tris-L-cysteinyl L-arginyl diiron disulfide" EXACT RESID-name [] xref: DiffAvg: "172.79" xref: DiffFormula: "C 0 Fe 2 H -3 N 0 O 0 S 2" xref: DiffMono: "172.791639" xref: FormalCharge: "2-" xref: Formula: "C 15 Fe 2 H 24 N 7 O 4 S 5" xref: MassAvg: "638.39" xref: MassMono: "637.920304" xref: Origin: "C, C, C, R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00363 name: L-cysteinyl-L-selenocysteine (Cys-Sec) def: "A protein modification that effectively cross-links an L-cysteine residue and an L-selenocysteine residues to form L-cysteinyl-L-selenocystine." [PubMed:12911312, RESID:AA0358#SEC] comment: Cross-link 2. subset: PSI-MOD-slim synonym: "(R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Cysteinyl-selenocysteine (Cys-Sec)" EXACT UniProt-feature [] synonym: "CROSSLNK Cysteinyl-selenocysteine (Sec-Cys)" EXACT UniProt-feature [] synonym: "L-cysteinyl-L-selenocysteine" EXACT RESID-name [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0 Se 0" xref: DiffMono: "-2.015650" xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1" xref: MassAvg: "251.17" xref: MassMono: "251.947170" xref: Origin: "C, U" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01158 ! modified L-selenocysteine residue is_a: MOD:01627 ! L-cysteinyl-L-selenocysteine [Term] id: MOD:00364 name: 5-hydroxy-N6,N6,N6-trimethyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 5-hydroxy-N6,N6,N6-trimethyl-L-lysine." [PubMed:11349130, PubMed:14661085, RESID:AA0359, UniMod:445#K] comment: Incidental to RESID:AA0278; secondary to RESID:AA0028; secondary to RESID:AA0074. synonym: "(2R,5Xi)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentan-1-aminium" EXACT RESID-systematic [] synonym: "(2Xi,5S)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentanaminium" EXACT RESID-alternate [] synonym: "(2Xi,5S)-5-azanyl-5-carboxy-2-hydroxy-N,N,N-trimethylpentanazanium" EXACT RESID-alternate [] synonym: "5-hydroxy-N(zeta)-trimethyllysine" EXACT RESID-alternate [] synonym: "5-hydroxy-N6,N6,N6-trimethyl" RELATED UniMod-description [] synonym: "5-hydroxy-N6,N6,N6-trimethyl-L-lysine" EXACT RESID-name [] synonym: "5-hydroxy-N6,N6,N6-trimethyllysin-N6-ium" EXACT RESID-alternate [] synonym: "5-hydroxy-N6,N6,N6-trimethyllysine cation" EXACT RESID-alternate [] synonym: "5-hydroxylated N6,N6,N6-trimethylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "5HyN6Me3Lys" EXACT PSI-MOD-label [] synonym: "alpha-amino-epsilon-dimethylamino-delta-hydroxycaproic acid" EXACT RESID-alternate [] synonym: "delta-hydroxy-epsilon-N,N,N-trimethyllysine" EXACT RESID-alternate [] synonym: "Hydroxytrimethyl" RELATED PSI-MS-label [] synonym: "lysine derivative Lys(z)" EXACT RESID-alternate [] synonym: "MOD_RES N6,N6,N6-trimethyl-5-hydroxylysine" EXACT UniProt-feature [] xref: DiffAvg: "59.09" xref: DiffFormula: "C 3 H 7 N 0 O 1" xref: DiffMono: "59.049141" xref: FormalCharge: "1+" xref: Formula: "C 9 H 19 N 2 O 2" xref: MassAvg: "187.26" xref: MassMono: "187.144104" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00602 ! N-methylated residue is_a: MOD:00912 ! modified L-lysine residue relationship: has_functional_parent MOD:00037 ! 5-hydroxy-L-lysine relationship: has_functional_parent MOD:00083 ! N6,N6,N6-trimethyl-L-lysine [Term] id: MOD:00365 name: N-(L-isoglutamyl)-glycine def: "A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoglutamyl)-glycine." [PubMed:14531691, RESID:AA0360] comment: Cross-link 2. synonym: "(S)-2-amino-5-(carboxymethyl)amino-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "2-amino-N5-(carboxymethyl)-pentanediamic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Isoglutamyl glycine isopeptide (Gly-Glu)" EXACT UniProt-feature [] synonym: "isoglutamyl glycine" EXACT RESID-alternate [] synonym: "N-(L-isoglutamyl)-glycine" EXACT RESID-name [] synonym: "N-gamma-glutamylglycine" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 7 H 9 N 2 O 3" xref: MassAvg: "169.16" xref: MassMono: "169.061317" xref: Origin: "E, G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00688 ! isopeptide crosslinked residues is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00366 name: O-sulfo-L-serine def: "A protein modification that effectively converts an L-serine residue to O-sulfo-L-serine." [PubMed:14752058, RESID:AA0361, UniMod:40#S] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(sulfooxy)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-hydroxypropanoic acid 3-sulfate" EXACT RESID-alternate [] synonym: "MOD_RES Sulfoserine" EXACT UniProt-feature [] synonym: "O-sulfo-L-serine" EXACT RESID-name [] synonym: "O-Sulfonation" RELATED UniMod-description [] synonym: "O3-sulfonoserine" EXACT RESID-alternate [] synonym: "O3-sulfoserine" EXACT RESID-alternate [] synonym: "serine sulfate ester" EXACT RESID-alternate [] synonym: "Sulfo" RELATED PSI-MS-label [] xref: DiffAvg: "80.06" xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1" xref: DiffMono: "79.956815" xref: Formula: "C 3 H 5 N 1 O 5 S 1" xref: MassAvg: "167.13" xref: MassMono: "166.988843" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00695 ! sulfated residue is_a: MOD:00771 ! residues isobaric at 166.98-167.00 Da is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00367 name: O-sulfo-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-sulfo-L-threonine." [PubMed:14752058, RESID:AA0362, UniMod:40#T] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(sulfooxy)butanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-hydroxybutanoic acid 3-sulfate" EXACT RESID-alternate [] synonym: "MOD_RES Sulfothreonine" EXACT UniProt-feature [] synonym: "O-sulfo-L-threonine" EXACT RESID-name [] synonym: "O-Sulfonation" RELATED UniMod-description [] synonym: "O3-sulfonothreonine" EXACT RESID-alternate [] synonym: "O3-sulfothreonine" EXACT RESID-alternate [] synonym: "Sulfo" RELATED PSI-MS-label [] synonym: "threonine sulfate ester" EXACT RESID-alternate [] xref: DiffAvg: "80.06" xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1" xref: DiffMono: "79.956815" xref: Formula: "C 4 H 7 N 1 O 5 S 1" xref: MassAvg: "181.16" xref: MassMono: "181.004493" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00695 ! sulfated residue is_a: MOD:00773 ! residues isobaric at 181.00-181.02 Da is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00368 name: N-carboxy-L-methionine def: "A protein modification that effectively converts an L-methionine residue to N-carboxy-L-methionine." [PubMed:10368287, PubMed:11120890, PubMed:12595263, PubMed:8312270, RESID:AA0363, UniMod:299#M] comment: At least three protein crystallographic structures have been reported with this modification. However, no chemical evidence for this modification is provided, there were no reports of this modification before these crystallographic reports, and there is no metabolic explanation for the conversion of a formyl group to a carboxy group. There is confusion in its description, and misnaming is common. This modification is probably a misidentification of N-(dihydroxymethyl)methionine, the hydrated form of N-formylmethionine. See MOD:01446 [JSG]. synonym: "(S)-2-carboxyamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-carbamic-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "2-carbamic-4-(methylthio)butanoic acid" EXACT RESID-alternate [] synonym: "Carboxy" RELATED UniMod-interim [] synonym: "Carboxylation" RELATED UniMod-description [] synonym: "N-carboxy-L-methionine" EXACT RESID-name [] synonym: "N-carboxymethionine" EXACT RESID-alternate [] xref: DiffAvg: "44.01" xref: DiffFormula: "C 1 H 0 N 0 O 2 S 0" xref: DiffMono: "43.989829" xref: Formula: "C 6 H 10 N 1 O 3 S 1" xref: MassAvg: "176.21" xref: MassMono: "176.038139" xref: Origin: "M" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01152 ! carboxylated residue [Term] id: MOD:00369 name: O-acetyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-acetyl-L-serine." [ChEBI:17981, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:16731519, PubMed:489587, PubMed:7309355, RESID:AA0364, UniMod:1#S] comment: incidental to RESID:AA0051 subset: PSI-MOD-slim synonym: "(2S)-3-(acetyloxy)-2-aminopropanoic acid" EXACT RESID-systematic [] synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "Acetylation" RELATED UniMod-description [] synonym: "MOD_RES O-acetylserine" EXACT UniProt-feature [] synonym: "O-acetyl-L-serine" EXACT RESID-name [] synonym: "O-acetylated L-serine" EXACT PSI-MOD-alternate [] synonym: "O-acetylserine" EXACT RESID-alternate [] synonym: "OAcSer" EXACT PSI-MOD-label [] synonym: "serine acetate ester" EXACT RESID-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00644 ! O-acetylated residue is_a: MOD:00647 ! acetylated L-serine [Term] id: MOD:00370 name: (E)-2,3-didehydrotyrosine def: "A protein modification that effectively converts an L-tyrosine residue to (E)-2,3-didehydrotyrosine." [PubMed:12623015, RESID:AA0365] comment: incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 subset: PSI-MOD-slim synonym: "(2E)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid" EXACT RESID-systematic [] synonym: "(E)-2,3-didehydrogenated tyrosine" EXACT PSI-MOD-alternate [] synonym: "(E)-2,3-didehydrotyrosine" EXACT RESID-name [] synonym: "2-amino-3-oxo-butanoic_acid" RELATED UniMod-description [] synonym: "amino-(para-hydroxybenzylidenyl)acetic acid" EXACT RESID-alternate [] synonym: "blue non-fluorescent pocilloporin chromophore" EXACT RESID-alternate [] synonym: "Didehydro" RELATED PSI-MS-label [] synonym: "E-dHTyr" EXACT PSI-MOD-label [] synonym: "MOD_RES (E)-2,3-didehydrotyrosine" EXACT UniProt-feature [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "trans-dehydrotyrosine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 9 H 7 N 1 O 2" xref: MassAvg: "161.16" xref: MassMono: "161.047678" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00706 ! dehydrogenated tyrosine [Term] id: MOD:00371 name: bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide def: "A protein modification that effectively converts two L-aspartic acid residues, three L-glutamic acid residues, an L-histidine residue, and a one-calcium, four-iron, four-oxygen cluster to bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide." [PubMed:14764885, RESID:AA0366] comment: Cross-link 6. synonym: "4Mn-Ca-4O cluster" EXACT RESID-alternate [] synonym: "bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide" EXACT RESID-name [] synonym: "mu3-1:2:3kappaO-oxido-mu3-1:3:4kappaO-oxido-mu3-2:3:4kappaO-oxido-mu4-1:2:4:5kappaO-oxido-N1'-histidino-O5-glutamato 2-manganese-O5,O5-glutamato 3-manganese-O4-aspartato 4-manganese-O4-aspartato-O5-glutamato 5-manganese" EXACT RESID-systematic [] synonym: "photosystem II catalytic cluster" EXACT RESID-alternate [] xref: DiffAvg: "317.78" xref: DiffFormula: "C 0 Ca 1 H -6 Mn 4 N 0 O 4" xref: DiffMono: "317.647480" xref: Formula: "C 29 Ca 1 H 32 Mn 4 N 8 O 20" xref: MassAvg: "1072.44" xref: MassMono: "1071.888057" xref: Origin: "D, D, E, E, E, H" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00740 ! manganese containing modified residue is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01482 ! calcium containing modified residue [Term] id: MOD:00372 name: 3'-(3'-L-tyrosinyl)-L-tyrosine def: "A protein modification that effectively cross-links two L-tyrosine residues with a carbon-carbon bond to form 3'-(3'-L-tyrosinyl)-L-tyrosine." [DeltaMass:0, PubMed:14249161, PubMed:637884, PubMed:8702710, PubMed:8937563, RESID:AA0367] comment: Cross-link 2; From DeltaMass: Average Mass: -2. synonym: "(2S,2'S)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)bis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "3'-(L-tyros-3'-yl)-L-tyrosine" EXACT RESID-name [] synonym: "3,3'-BiTyr (Crosslink)" EXACT DeltaMass-label [] synonym: "6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-bis(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "alpha,alpha'-diamino-6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-dipropanoic acid" EXACT RESID-alternate [] synonym: "bityrosine" EXACT RESID-alternate [] synonym: "o,o-dityrosine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 18 H 16 N 2 O 4" xref: MassAvg: "324.34" xref: MassMono: "324.111007" xref: Origin: "Y, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00373 name: 3'-(O4'-L-tyrosinyl)-L-tyrosine def: "A protein modification that effectively cross-links L-tyrosine residues with an ether bond to form 3'-(O4'-L-tyrosinyl)-L-tyrosine." [DeltaMass:0, PubMed:12719529, PubMed:7115340, PubMed:8702710, RESID:AA0368] comment: Cross-link 2; secondary to RESID:AA0146; From DeltaMass: Average Mass: -2. synonym: "(2S)-2-amino-3-[3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-4-hydroxyphenyl]propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-[4-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenoxy)phenyl]propanoic acid" EXACT RESID-alternate [] synonym: "3'-(L-tyros-O4'-yl)-L-tyrosine" EXACT RESID-name [] synonym: "CROSSLNK Isodityrosine (Tyr-Tyr)" EXACT UniProt-feature [] synonym: "IsodiTyr (Crosslink)" EXACT DeltaMass-label [] synonym: "isodityrosine" EXACT RESID-alternate [] synonym: "O-(5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)-L-tyrosine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 18 H 16 N 2 O 4" xref: MassAvg: "324.34" xref: MassMono: "324.111007" xref: Origin: "Y, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00374 name: 3,4-dihydroxy-L-arginine def: "A protein modification that effectively converts an L-arginine residue to 3,4-dihydroxy-L-arginine." [PubMed:10978343, PubMed:12686488, RESID:AA0369, UniMod:425#R] synonym: "(2S,3Xi,4Xi)-2-amino-5-carbamimidamido-3,4-dihydroxypentanoic acid" EXACT RESID-systematic [] synonym: "2-amino-5-guanidino-3,4-dihydroxypentanoic acid" EXACT RESID-alternate [] synonym: "3,4-dihydroxy-L-arginine" EXACT RESID-name [] synonym: "3,4-dihydroxylated L-arginine" EXACT PSI-MOD-alternate [] synonym: "34Hy2Arg" EXACT PSI-MOD-label [] synonym: "beta,gamma-dihydroxyarginine" EXACT RESID-alternate [] synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] synonym: "MOD_RES 3,4-dihydroxyarginine" EXACT UniProt-feature [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 6 H 12 N 4 O 3" xref: MassAvg: "188.19" xref: MassMono: "188.090940" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00428 ! dihydroxylated residue is_a: MOD:00682 ! hydroxylated arginine [Term] id: MOD:00375 name: 4,5-dihydroxy-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 4,5-dihydroxy-L-lysine." [PubMed:10978343, PubMed:12686488, RESID:AA0370, UniMod:425#K] synonym: "(2S,4Xi,5Xi)-2,6-diamino-4,5-dihydroxyhexanoic acid" EXACT RESID-systematic [] synonym: "4,5-dihydroxy-L-lysine" EXACT RESID-name [] synonym: "4,5-dihydroxylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "45Hy2Lys" EXACT PSI-MOD-label [] synonym: "alpha,epsilon-diamino-delta,gamma-dihydroxycaproic acid" EXACT RESID-alternate [] synonym: "delta,gamma-dihydroxylysine" EXACT RESID-alternate [] synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] synonym: "MOD_RES 4,5-dihydroxylysine" EXACT UniProt-feature [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 6 H 12 N 2 O 3" xref: MassAvg: "160.17" xref: MassMono: "160.084792" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00428 ! dihydroxylated residue is_a: MOD:00681 ! hydroxylated lysine [Term] id: MOD:00376 name: 1'-(phospho-5'-adenosine)-L-histidine def: "A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form 1'-(phospho-5'-adenosine)-L-histidine." [PubMed:15182206, PubMed:9323207, RESID:AA0371, UniMod:405#H] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-[1-(5'-adenosine phosphono)imidazol-4-yl]propanoic acid" EXACT RESID-systematic [] synonym: "1'-(phospho-5'-adenosine)-L-histidine" EXACT RESID-name [] synonym: "ACT_SITE Tele-AMP-histidine intermediate" EXACT UniProt-feature [] synonym: "AMP binding site" RELATED UniMod-description [] synonym: "L-histidine 5'-adenosine phosphoramidester" EXACT RESID-alternate [] synonym: "L-histidine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate [] synonym: "N(tau)-5'-adenylic-L-histidine" EXACT RESID-alternate [] synonym: "N1'-adenylylated histidine" EXACT RESID-alternate [] synonym: "Phosphoadenosine" RELATED PSI-MS-label [] synonym: "tele-5'-adenylic-L-histidine" EXACT RESID-alternate [] xref: DiffAvg: "329.21" xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" xref: DiffMono: "329.052520" xref: Formula: "C 16 H 19 N 8 O 7 P 1" xref: MassAvg: "466.35" xref: MassMono: "466.111432" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01165 ! adenylated residue [Term] id: MOD:00377 name: 1'-(phospho-5'-uridine)-L-histidine def: "A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphouridine through a phosphoramide ester bond to form 1'-(phospho-5'-uridine)-L-histidine." [PubMed:11467524, PubMed:321007, PubMed:380639, PubMed:8794735, RESID:AA0372, UniMod:417#H] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-[1-(5'-uridine phosphono)imidazol-4-yl]propanoic acid" EXACT RESID-systematic [] synonym: "1'-(phospho-5'-uridine)-L-histidine" EXACT RESID-name [] synonym: "ACT_SITE Tele-UMP-histidine intermediate" EXACT UniProt-feature [] synonym: "L-histidine 5'-uridine phosphoramidester" EXACT RESID-alternate [] synonym: "L-histidine monoanhydride with 5'-uridylic acid" EXACT RESID-alternate [] synonym: "N(tau)-5'-uridylic-L-histidine" EXACT RESID-alternate [] synonym: "N1'-uridylylated histidine" EXACT RESID-alternate [] synonym: "PhosphoUridine" RELATED PSI-MS-label [] synonym: "tele-5'-uridylic-L-histidine" EXACT RESID-alternate [] synonym: "uridine phosphodiester" RELATED UniMod-description [] xref: DiffAvg: "306.17" xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1" xref: DiffMono: "306.025302" xref: Formula: "C 15 H 18 N 5 O 9 P 1" xref: MassAvg: "443.31" xref: MassMono: "443.084214" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01166 ! uridylated residue [Term] id: MOD:00378 name: L-aspartyl semialdehyde def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl semialdehyde." [PubMed:1093385, PubMed:14235557, PubMed:15237995, RESID:AA0373, UniMod:447#D] subset: PSI-MOD-slim synonym: "(S)-2-amino-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "aspartyl 4-semialdehyde" EXACT PSI-MOD-alternate [] synonym: "aspartyl aldehyde" EXACT PSI-MOD-alternate [] synonym: "Deoxy" RELATED PSI-MS-label [] synonym: "L-aminosuccinaldehydic acid" EXACT RESID-alternate [] synonym: "L-aminosuccinic acid semialdehyde" EXACT RESID-alternate [] synonym: "L-aspartate-beta-semialdehyde" EXACT RESID-alternate [] synonym: "L-aspartic beta-semialdehyde" EXACT RESID-alternate [] synonym: "L-aspartyl aldehyde" EXACT RESID-name [] synonym: "L-beta-formylalanine" EXACT RESID-alternate [] synonym: "MOD_RES Aspartyl aldehyde" EXACT UniProt-feature [] synonym: "reduction" RELATED UniMod-description [] xref: DiffAvg: "-16.00" xref: DiffFormula: "C 0 H 0 N 0 O -1" xref: DiffMono: "-15.994915" xref: Formula: "C 4 H 5 N 1 O 2" xref: MassAvg: "99.09" xref: MassMono: "99.032028" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01161 ! deoxygenated residue [Term] id: MOD:00379 name: L-serine microcin E492 siderophore ester def: "A protein modification that effectively converts an L-serine residue to L-serine microcin E492 siderophore ester." [PubMed:15102848, RESID:AA0374, UniMod:448#C-term] comment: UniMod origin corrected [JSG]. synonym: "L-serine microcin E492 siderophore ester" EXACT RESID-name [] synonym: "Microcin" RELATED PSI-MS-label [] synonym: "microcin E492 siderophore ester from serine" RELATED UniMod-description [] synonym: "MOD_RES Serine microcin E492 siderophore ester" EXACT UniProt-feature [] synonym: "N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine" EXACT RESID-systematic [] xref: DiffAvg: "831.69" xref: DiffFormula: "C 36 H 37 N 3 O 20" xref: DiffMono: "831.197041" xref: Formula: "C 39 H 43 N 4 O 23" xref: MassAvg: "935.78" xref: MassMono: "935.231809" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00380 name: L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:12910261, PubMed:14725769, RESID:AA0375, UniMod:424#D] synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate [] synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-aspartyl-molybdenum" EXACT RESID-systematic [] synonym: "L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name [] synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED UniMod-description [] synonym: "MolybdopterinGD" RELATED PSI-MS-label [] synonym: "nitrate reductase A aspartyl Mo-bisMGD cofactor" EXACT RESID-alternate [] synonym: "phosphoric acid 4-(2-amino-4-oxo-3,4,5,6,-tetrahydro-pteridin-6-yl)-2-hydroxy-3,4-dimercapto-but-3-en-yl ester guanylate ester" EXACT RESID-alternate [] xref: DiffAvg: "1572.02" xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4" xref: DiffMono: "1572.985775" xref: Formula: "C 44 H 52 Mo 1 N 21 O 29 P 4 S 4" xref: MassAvg: "1687.10" xref: MassMono: "1688.012718" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01167 ! molybdopterin guanine dinucleotide [Term] id: MOD:00381 name: L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Sec) def: "A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PubMed:11372198, PubMed:12220497, RESID:AA0376#SEC] xref: DiffAvg: "1691.97" xref: DiffFormula: "C 40 H 47 N 20 O 26 P 4 S 5 Se 0 W 1" xref: DiffMono: "1691.003369" xref: Formula: "C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1" xref: MassAvg: "1842.02" xref: MassMono: "1841.957004" xref: Origin: "U" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00746 ! tungsten containing modified residue is_a: MOD:00748 ! pterin modified residue is_a: MOD:01158 ! modified L-selenocysteine residue [Term] id: MOD:00382 name: 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one def: "A protein modification that effectively crosslinks an L-methionyl-L-tyrosine dipeptide to form 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one." [PubMed:10852900, PubMed:11259412, PubMed:15491166, RESID:AA0377] comment: carboxamidine; cross-link 1. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "3-(2-methylsulfanyl)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one" EXACT RESID-systematic [] synonym: "3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-amino-3,6-didehydropyrazin-2-ol" EXACT RESID-alternate [] synonym: "3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one" EXACT RESID-name [] synonym: "GFP-like chromoprotein asFP595 chromophore" EXACT RESID-alternate [] synonym: "L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT RESID-alternate [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 14 H 15 N 2 O 2 S 1" xref: MassAvg: "275.35" xref: MassMono: "275.085424" xref: Origin: "M, Y" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00383 name: 2-imino-glutamic acid 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue to form 2-imino-glutamic acid 5-imidazolinone glycine." [PubMed:11682051, RESID:AA0378] comment: Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "2,N-didehydroglutamyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "2-(3-carboxy-1-iminopropyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "2-imino-glutamic acid 5-imidazolinone glycine" EXACT RESID-name [] synonym: "2-imino-glutamyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "4-[1-(carboxymethyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-iminobutanoic acid" EXACT RESID-systematic [] synonym: "[2-(3-carboxy-1-iminopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Glu-Gly)" EXACT UniProt-feature [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1" xref: DiffMono: "-20.026215" xref: Formula: "C 7 H 6 N 2 O 3" xref: MassAvg: "166.14" xref: MassMono: "166.037842" xref: Origin: "E, G" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00384 name: 2-imino-methionine 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-methionine residue and a glycine residue to form 2-imino-methionine 5-imidazolinone glycine." [PubMed:10852900, PubMed:12185250, PubMed:12909624, PubMed:15542608, RESID:AA0379] comment: Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "(2-[1-imino-3-(methylsulfanyl)propyl]-5-oxo-4,5-dihydro-imidazol-1-yl)acetic acid" EXACT RESID-alternate [] synonym: "(2-[3-(methylsulfanyl)propanimidoyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] synonym: "2,N-didehydromethionyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "2-[1-imino-3-(methylsulfanyl)propyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "2-imino-methionine 5-imidazolinone glycine" EXACT RESID-name [] synonym: "2-imino-methionyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Met-Gly)" EXACT UniProt-feature [] synonym: "GFP-like chromoprotein asFP595 chromophore" EXACT RESID-alternate [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "red fluorescent protein eqFP611 chromophore" EXACT RESID-alternate [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 7 H 8 N 2 O 1 S 1" xref: MassAvg: "168.21" xref: MassMono: "168.035734" xref: Origin: "G, M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00385 name: L-asparagine 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue to form L-asparagine 5-imidazolinone glycine." [PubMed:10504696, RESID:AA0380] comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "(2-[(1S)-1,3-diamino-3-oxopropyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] synonym: "2-[(S)-1,3-diamino-3-oxopropyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "[2-(1,3-diamino-3-oxopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] synonym: "asparaginyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "CROSSLNK 5-imidazolinone (Asn-Gly)" EXACT UniProt-feature [] synonym: "L-asparagine 5-imidazolinone glycine" EXACT RESID-name [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "Zoanthus sp. fluorescent protein FP506 chromophore" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 7 N 3 O 2" xref: MassAvg: "153.14" xref: MassMono: "153.053826" xref: Origin: "G, N" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00386 name: L-lysine 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form L-lysine 5-imidazolinone glycine." [PubMed:10504696, RESID:AA0381] comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "(2-[(1S)-1,5-diaminopentyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] synonym: "2-[(S)-1,5-diaminopentanyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "[2-(1,5-diaminopentanyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] synonym: "Anemonia majano fluorescent protein FP486 chromophore" EXACT RESID-alternate [] synonym: "CROSSLNK 5-imidazolinone (Lys-Gly)" EXACT UniProt-feature [] synonym: "L-lysine 5-imidazolinone glycine" EXACT RESID-name [] synonym: "lysyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 8 H 13 N 3 O 1" xref: MassAvg: "167.21" xref: MassMono: "167.105862" xref: Origin: "G, K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00387 name: 2-tetrahydropyridinyl-5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form 2-tetrahydropyridinyl-5-imidazolinone glycine." [PubMed:10504696, PubMed:15628861, RESID:AA0382] comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. synonym: "2-(3,4,5,6-tetrahydropyridin-2-yl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "2-(tetrahydropyrid-2-yl)-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT RESID-name [] synonym: "[5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-alternate [] synonym: "[5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-systematic [] synonym: "CROSSLNK 2-tetrahydro-2-pyridyl-5-imidazolinone (Lys-Gly)" EXACT UniProt-feature [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "Zoanthus sp. fluorescent protein zFP538 chromophore" EXACT RESID-alternate [] xref: DiffAvg: "-37.06" xref: DiffFormula: "C 0 H -7 N -1 O -1" xref: DiffMono: "-37.052764" xref: Formula: "C 8 H 9 N 2 O 1" xref: MassAvg: "149.17" xref: MassMono: "149.071488" xref: Origin: "G, K" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00388 name: L-alanyl-pentaglycyl-murein peptidoglycan def: "A protein modification that effectively attaches an L-alanine residue to murein peptidoglycan by a pentaglycine linker peptide." [PubMed:8163519, RESID:AA0383] synonym: "(2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(alanyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine" EXACT RESID-alternate [] synonym: "L-alanyl-pentaglycyl-murein peptidoglycan" EXACT RESID-name [] synonym: "MOD_RES Pentaglycyl murein peptidoglycan amidated alanine" EXACT UniProt-feature [] xref: DiffAvg: "268.25" xref: DiffFormula: "C 10 H 14 N 5 O 4" xref: DiffMono: "268.104579" xref: Formula: "C 13 H 20 N 6 O 6" xref: MassAvg: "356.34" xref: MassMono: "356.144432" xref: Origin: "A" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:01159 ! peptidoglycanated residue [Term] id: MOD:00389 name: N-formyl-L-proline def: "A protein modification that effectively converts an L-proline residue to N-formyl-L-proline." [PubMed:12051774, PubMed:5464655, RESID:AA0384, UniMod:122#N-term] comment: CAUTION - observations of this modification can be attributed to unintended artifactual production, or to spurious peptide MS identification. This modification is probably not a natural post-translational modification [JSG]. synonym: "(2S)-1-formylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "1-formyl-2-pyrrolidinecarboxylic acid" EXACT RESID-alternate [] synonym: "1-formylproline" EXACT RESID-alternate [] synonym: "N-formyl-L-proline" EXACT RESID-name [] synonym: "N-formylated L-proline" EXACT PSI-MOD-alternate [] synonym: "NFoPro" EXACT PSI-MOD-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 6 H 8 N 1 O 2" xref: MassAvg: "126.14" xref: MassMono: "126.055504" xref: Origin: "P" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00409 ! N-formylated residue is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:00390 name: O-decanoyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-decanoyl-L-serine." [PubMed:12630926, RESID:AA0385, UniMod:449#S] synonym: "(2S)-2-amino-3-(decanoyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "Decanoyl" RELATED PSI-MS-label [] synonym: "L-serine decanoate ester" EXACT RESID-alternate [] synonym: "lipid" RELATED UniMod-description [] synonym: "LIPID O-decanoyl serine" EXACT UniProt-feature [] synonym: "O-decanoyl-L-serine" EXACT RESID-name [] synonym: "O-decanoylated L-serine" EXACT PSI-MOD-alternate [] synonym: "O3-decanoyl-L-serine" EXACT RESID-alternate [] synonym: "ODecSer" EXACT PSI-MOD-label [] xref: DiffAvg: "154.25" xref: DiffFormula: "C 10 H 18 N 0 O 1" xref: DiffMono: "154.135765" xref: Formula: "C 13 H 23 N 1 O 3" xref: MassAvg: "241.33" xref: MassMono: "241.167794" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00668 ! O-decanoylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00391 name: O-octanoyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-octanoyl-L-threonine." [PubMed:11546772, PubMed:12716131, RESID:AA0386, UniMod:426#T] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(octanoyloxy)butanoic acid" EXACT RESID-systematic [] synonym: "L-threonine octanoate ester" EXACT RESID-alternate [] synonym: "LIPID O-octanoyl threonine" EXACT UniProt-feature [] synonym: "O-octanoyl-L-threonine" EXACT RESID-name [] synonym: "O-octanoylated L-threonine" EXACT PSI-MOD-alternate [] synonym: "O3-octanoyl-L-threonine" EXACT RESID-alternate [] synonym: "Octanoyl" RELATED PSI-MS-label [] synonym: "octanoyl" RELATED UniMod-description [] synonym: "OOctThr" EXACT PSI-MOD-label [] xref: DiffAvg: "126.20" xref: DiffFormula: "C 8 H 14 N 0 O 1" xref: DiffMono: "126.104465" xref: Formula: "C 12 H 21 N 1 O 3" xref: MassAvg: "227.30" xref: MassMono: "227.152144" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00669 ! O-octanoylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00392 name: O-decanoyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-decanoyl-L-threonine." [PubMed:11546772, RESID:AA0387, UniMod:449#T] synonym: "(2S)-2-amino-3-(decanoyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "Decanoyl" RELATED PSI-MS-label [] synonym: "L-threonine decanoate ester" EXACT RESID-alternate [] synonym: "lipid" RELATED UniMod-description [] synonym: "LIPID O-decanoyl threonine" EXACT UniProt-feature [] synonym: "O-decanoyl-L-threonine" EXACT RESID-name [] synonym: "O-decanoylated L-threonine" EXACT PSI-MOD-alternate [] synonym: "O3-decanoyl-L-threonine" EXACT RESID-alternate [] synonym: "ODecThr" EXACT PSI-MOD-label [] xref: DiffAvg: "154.25" xref: DiffFormula: "C 10 H 18 N 0 O 1" xref: DiffMono: "154.135765" xref: Formula: "C 14 H 25 N 1 O 3" xref: MassAvg: "255.36" xref: MassMono: "255.183444" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00668 ! O-decanoylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00393 name: O-methylated residue def: "A protein modification that effectively replaces a hydroxyl group hydrogen with a methyl group to produce either an ether from an alcohol or an ester from an acid." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OMeRes" EXACT PSI-MOD-label [] is_a: MOD:00427 ! methylated residue [Term] id: MOD:00394 name: acetylated residue def: "A protein modification that effectively replaces a hydrogen atom with an acetyl group." [DeltaMass:0, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, UniMod:1] comment: Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42 subset: PSI-MOD-slim synonym: "Acetyl" RELATED PSI-MS-label [] synonym: "Acetylation" RELATED UniMod-description [] synonym: "Acetylation (N terminus, N epsilon of Lysine, O of Serine) (Ac)" EXACT DeltaMass-label [] synonym: "AcRes" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 O 1" xref: DiffMono: "42.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue [Term] id: MOD:00395 name: thioester crosslinked residues def: "A protein modification that crosslinks two residues by formation of a thioester bond between a cysteine thiol and either an alpha-carbonyl, as in S-(L-methionyl-L-cysteine), or a sidechain carbonyl, as in S-(L-isoglutamyl)-L-cysteine." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00033 ! crosslinked residues is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00396 name: O-glycosylated residue def: "A protein modification that effectively replaces a residue hydrogen atom on an oxygen with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OGlycoRes" EXACT PSI-MOD-label [] is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00397 name: iodoacetamide derivatized residue def: "A protein modification that is produced by reaction with iodoacetamide, usually replacement of a reactive hydrogen with a methylcarboxamido group." [PubMed:11327326, PubMed:11510821, PubMed:12422359, UniMod:4] subset: PSI-MOD-slim synonym: "Carbamidomethyl" RELATED PSI-MS-label [] synonym: "Iodoacetamide derivative" RELATED UniMod-description [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1" xref: DiffMono: "57.021464" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00398 name: carbamoylated residue def: "A protein modification that effectively replaces a hydrogen atom with a carbamoyl (carboxamido) group. Replacement of an amino hydrogen produces a ureido group." [DeltaMass:56, PubMed:10978403, PubMed:12203680, UniMod:5] comment: This modification can be produced by hydrogen cyanate, either used as a reagent or as released by urea degradation in solution [JSG]. subset: PSI-MOD-slim synonym: "Carbamyl" RELATED UniMod-interim [] synonym: "Carbamylation" EXACT DeltaMass-label [] synonym: "Carbamylation" RELATED UniMod-description [] xref: DiffAvg: "43.02" xref: DiffFormula: "C 1 H 1 N 1 O 1" xref: DiffMono: "43.005814" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00399 name: iodoacetic acid derivatized residue def: "A protein modification that is produced by reaction with iodoacetic acid, usually replacement of a reactive hydrogen with a methylcarboxy group." [DeltaMass:64, UniMod:6] comment: From DeltaMass: Average Mass: 58 Abbreviation:CmC Average Mass Change:58 Notes:Cysteine reacts with iodoacetic acid to produce carboxymethyl cysteine. subset: PSI-MOD-slim synonym: "Carboxymethyl" RELATED PSI-MS-label [] synonym: "Carboxymethyl (on Cysteine)" EXACT DeltaMass-label [] synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 O 2" xref: DiffMono: "58.005479" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00400 name: deamidated residue def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group, with both a gain of oxygen and loss of a nitrogen and a hydrogen." [DeltaMass:32, OMSSA:4, UniMod:7] comment: From DeltaMass: References:Vish Katta. subset: PSI-MOD-slim synonym: "Deamidated" RELATED PSI-MS-label [] synonym: "Deamidation" RELATED UniMod-description [] synonym: "Deamidation of Asparagine and Glutamine to Aspartate and Glutamate" EXACT DeltaMass-label [] synonym: "deamidationkq" EXACT OMSSA-label [] synonym: "dNRes" EXACT PSI-MOD-label [] xref: DiffAvg: "0.98" xref: DiffFormula: "H -1 N -1 O 1" xref: DiffMono: "0.984016" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00401 name: Gygi ICAT(TM) d0 modified cysteine def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d0 reagent." [PubMed:10504701, UniMod:8#C] synonym: "Gygi ICAT(TM) d0" RELATED UniMod-description [] synonym: "ICAT-G" RELATED PSI-MS-label [] xref: DiffAvg: "486.63" xref: DiffFormula: "C 22 H 38 N 4 O 6 S 1" xref: DiffMono: "486.251206" xref: Formula: "C 25 H 43 N 5 O 7 S 2" xref: MassAvg: "589.77" xref: MassMono: "589.260391" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine [Term] id: MOD:00402 name: Gygi ICAT(TM) d8 modified cysteine def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d8 reagent." [PubMed:10504701, UniMod:9#C] synonym: "Gygi ICAT(TM) d8" RELATED UniMod-description [] synonym: "ICAT-G:2H(8)" RELATED PSI-MS-label [] xref: DiffAvg: "494.30" xref: DiffFormula: "C 22 (1)H 30 (2)H 8 N 4 O 6 S 1" xref: DiffMono: "494.301420" xref: Formula: "C 25 (1)H 35 (2)H 8 N 5 O 7 S 2" xref: MassAvg: "597.31" xref: MassMono: "597.310605" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01431 ! (2)H deuterium tagged reagent is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine [Term] id: MOD:00403 name: homoserine def: "A protein modification that effectively converts an L-methionine residue to homoserine." [DeltaMass:113, OMSSA:56, UniMod:10#M] comment: Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group and the following residue amino group. subset: PSI-MOD-slim synonym: "ctermpephsem" EXACT OMSSA-label [] synonym: "Homoserine" RELATED UniMod-description [] synonym: "Homoserine formed from Met by CNBr treatment" EXACT DeltaMass-label [] synonym: "Met->Hse" RELATED PSI-MS-label [] xref: DiffAvg: "-30.09" xref: DiffFormula: "C -1 H -2 O 1 S -1" xref: DiffMono: "-29.992806" xref: Formula: "C 4 H 7 N 1 O 2" xref: MassAvg: "101.10" xref: MassMono: "101.047678" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00404 name: homoserine lactone def: "A protein modification that effectively converts an L-methionine residue to homoserine lactone." [DeltaMass:90, OMSSA:57, UniMod:11#M] comment: Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group. Under acid conditions the homoserine dehydrates to form the cyclic lactone. subset: PSI-MOD-slim synonym: "ctermpephselactm" EXACT OMSSA-label [] synonym: "Homoserine lactone" RELATED UniMod-description [] synonym: "Met->Hsl" RELATED UniMod-interim [] xref: DiffAvg: "-48.10" xref: DiffFormula: "C -1 H -4 S -1" xref: DiffMono: "-48.003371" xref: Formula: "C 4 H 5 N 1 O 1" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:00601 ! cyclized residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00405 name: Applied Biosystems original ICAT(TM) d8 modified cysteine def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d8 reagent." [UniMod:12#C] subset: PSI-MOD-slim synonym: "Applied Biosystems original ICAT(TM) d8" RELATED UniMod-description [] synonym: "ICAT-D:2H(8)" RELATED PSI-MS-label [] xref: DiffAvg: "450.28" xref: DiffFormula: "C 20 (1)H 26 (2)H 8 N 4 O 5 S 1" xref: DiffMono: "450.275205" xref: Formula: "C 23 (1)H 31 (2)H 8 N 5 O 6 S 2" xref: MassAvg: "553.28" xref: MassMono: "553.284390" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01431 ! (2)H deuterium tagged reagent is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine [Term] id: MOD:00406 name: Applied Biosystems original ICAT(TM) d0 modified cysteine def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d0 reagent." [UniMod:13#C] subset: PSI-MOD-slim synonym: "Applied Biosystems original ICAT(TM) d0" RELATED UniMod-description [] synonym: "ICAT-D" RELATED PSI-MS-label [] xref: DiffAvg: "442.22" xref: DiffFormula: "C 20 (1)H 34 N 4 O 5 S 1" xref: DiffMono: "442.224991" xref: Formula: "C 23 (1)H 39 N 5 O 6 S 2" xref: MassAvg: "545.23" xref: MassMono: "545.234176" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine [Term] id: MOD:00407 name: residue methyl ester def: "A protein modification that effectively replaces a carboxyl group with a carboxy methyl ester group. OBSOLETE because UniMod:14 merged with entry 34, remap to MOD:00599." [PubMed:18688235] synonym: "ResOMe" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2" xref: DiffMono: "14.015650" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00408 name: N-acetylated residue def: "A protein modification that effectively replaces a residue amino or imino hydrogen with an acetyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "N-Acetyl" EXACT PSI-MOD-alternate [] synonym: "N-Acetylation" EXACT PSI-MOD-alternate [] synonym: "NAcRes" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 O 1" xref: DiffMono: "42.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00394 ! acetylated residue is_a: MOD:00670 ! N-acylated residue [Term] id: MOD:00409 name: N-formylated residue def: "A protein modification that effectively replaces a residue amino group with a formamido group." [OMSSA:44, OMSSA:82] subset: PSI-MOD-slim synonym: "Formyl" RELATED PSI-MS-label [] synonym: "NFoRes" EXACT PSI-MOD-label [] synonym: "ntermformyl" EXACT OMSSA-label [] synonym: "ntermpepformyl" EXACT OMSSA-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 O 1" xref: DiffMono: "27.994915" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00493 ! formylated residue is_a: MOD:00670 ! N-acylated residue [Term] id: MOD:00410 name: S-(N-isopropylcarboxamidomethyl)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(N-isopropylcarboxamidomethyl)-L-cysteine." [OMSSA:84, PubMed:11465505, PubMed:8465942, UniMod:17#C] synonym: "N-isopropylcarboxamidomethyl" RELATED UniMod-description [] synonym: "NIPCAM" RELATED PSI-MS-label [] synonym: "nipcam" EXACT OMSSA-label [] xref: DiffAvg: "99.13" xref: DiffFormula: "C 5 H 9 N 1 O 1 S 0" xref: DiffMono: "99.068414" xref: Formula: "C 8 H 14 N 2 O 2 S 1" xref: MassAvg: "202.27" xref: MassMono: "202.077599" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00411 name: O18 label def: "modification from UniMod Isotopic label. OBSOLETE because UniMod:18 is now merged with entry 258 remap to MOD:00581 'single 018 label'" [PubMed:18688235] comment: A modification from UniMod:18 xref: DiffAvg: "2.00" xref: DiffFormula: "(16)O -1 (18)O 1" xref: DiffMono: "2.004246" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00412 name: oxidation def: "modification from UniMod artifact. OBSOLETE because UniMod entry 19 is now merged with UniMod 35 remap to MOD:00425 'monohydroxylated residue'." [PubMed:18688235] xref: DiffAvg: "16.00" xref: DiffFormula: "O 1" xref: DiffMono: "15.994915" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00413 name: biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine def: "A protein modification that is produced by reaction of a cysteine residue with biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine." [UniMod:20#C] synonym: "Biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine" RELATED UniMod-description [] synonym: "PEO-Iodoacetyl-LC-Biotin" RELATED UniMod-interim [] xref: DiffAvg: "414.52" xref: DiffFormula: "C 18 H 30 N 4 O 5 S 1" xref: DiffMono: "414.193691" xref: Formula: "C 21 H 35 N 5 O 6 S 2" xref: MassAvg: "517.66" xref: MassMono: "517.202876" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00414 name: monomethylated L-arginine def: "A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with one methyl group." [DeltaMass:215, OMSSA:77, UniMod:34#R] comment: From DeltaMass: formula incorrect, N and O reversed subset: PSI-MOD-slim synonym: "Me1Arg" EXACT PSI-MOD-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "methylr" EXACT OMSSA-label [] synonym: "N-methyl Arginyl" EXACT DeltaMass-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 14 N 4 O 1" xref: MassAvg: "170.22" xref: MassMono: "170.116761" xref: Origin: "R" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00658 ! methylated arginine [Term] id: MOD:00415 name: phosphorylation without neutral loss def: "modification from UniMod - OBSOLETE because UniMod entry 22 is now merged with entry 21 remap to MOD:00696 'phosphorylated residue'." [PubMed:18688235] xref: DiffAvg: "79.98" xref: DiffFormula: "H 1 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00416 name: phosphorylation of an hydroxyl amino acid with prompt loss of phosphate def: "A change resulting in an alteration of the measured molecular mass of a peptide or protein hydroxyl amino acid phosphorylated promptly followed by secondary loss of a neutral trihydrogen phosphate molecular fragment." [UniMod:23] comment: O4-phosphotyrosine does not lose phosphate by this mechanism. UniMod does not provide a citation for this particular modification [JSG]. subset: PSI-MOD-slim synonym: "Dehydrated" RELATED UniMod-interim [] synonym: "Dehydration" RELATED UniMod-description [] xref: DiffAvg: "-18.02" xref: DiffFormula: "H -2 O -1" xref: DiffMono: "-18.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00432 ! modified residue with neutral loss of phosphate is_a: MOD:00704 ! dehydrated residue [Term] id: MOD:00417 name: S-carboxamidoethyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidoethyl-L-cysteine." [DeltaMass:72, OMSSA:5, PubMed:1481983, UniMod:24#C] comment: From DeltaMass: References: Anal. Biochem. Vol 216 No. 1 p131 (citation not found) Notes: Residual acrylamide in SDS gels can label free cysteines to produce propionamido-Cys (also known as PAM-Cys) synonym: "Acrylamide adduct" RELATED UniMod-description [] synonym: "PAM-Cys" EXACT DeltaMass-label [] synonym: "Propionamide" RELATED PSI-MS-label [] synonym: "Propionamide or Acrylamide adduct" EXACT DeltaMass-label [] synonym: "propionamidec" EXACT OMSSA-label [] synonym: "S-(3-amino-3-oxopropyl)cysteine" EXACT PSI-MOD-alternate [] synonym: "S-carbamoylethyl-L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S-propanamide-L-cysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "71.08" xref: DiffFormula: "C 3 H 5 N 1 O 1 S 0" xref: DiffMono: "71.037114" xref: Formula: "C 6 H 10 N 2 O 2 S 1" xref: MassAvg: "174.22" xref: MassMono: "174.046299" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00418 name: pyridylacetylated residue def: "A protein modification that effectively replaces a hydrogen atom with an (pyridin-3-yl)acetyl group." [PubMed:9276974, UniMod:25] comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. synonym: "Pyridylacetyl" RELATED PSI-MS-label [] synonym: "pyridylacetyl" RELATED UniMod-description [] xref: DiffAvg: "119.12" xref: DiffFormula: "C 7 H 5 N 1 O 1" xref: DiffMono: "119.037114" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00419 name: (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid def: "A protein modification that effectively converts an L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid." [DeltaMass:336, PubMed:12643538, UniMod:26#C] comment: From DeltaMass: A secondary modification affecting peptides with S-carbamoylmethyl-L-cysteine (CamC) at the N-terminus. These exist in enzymatic digests of proteins that have been S-alkylated with iodoacetamide. Cyclization of N-terminal CamC gives a residue of (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid. Peptides in which this has occurred become more hydrophobic, and lose 17 Da from the N-terminal residue. synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label [] synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate [] synonym: "Otc" EXACT DeltaMass-label [] synonym: "Pyro-carbamidomethyl" RELATED UniMod-interim [] synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" EXACT DeltaMass-label [] synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED UniMod-description [] xref: DiffAvg: "40.02" xref: DiffFormula: "C 2 H 0 N 0 O 1 S 0" xref: DiffMono: "39.994915" xref: Formula: "C 5 H 6 N 1 O 2 S 1" xref: MassAvg: "144.17" xref: MassMono: "144.011924" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00601 ! cyclized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00420 name: 2-pyrrolidone-5-carboxylic acid (Glu) def: "A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid." [DeltaMass:16, OMSSA:109, PubMed:10214721, PubMed:1836357, PubMed:3473473, PubMed:8382902, RESID:AA0031#GLU, UniMod:27#E] comment: From DeltaMass: References: The conversion of glutamic acid to pyroglutamic was reported for the beta-amyloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52 [DeltaMass]. The modification in amyloid protein is probably an artifact of treatment with strong acid under anhydrous conditions. Peptides with N-terminal glutamic acid isolated from single cells of Aplysia neurons show partial conversion to pyroglutamic acid, possibly dependent on a temperature sensitive factor [JSG]. synonym: "(2S)-5-oxo-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic [] synonym: "2-oxopyrrolidine-5-carboxylic acid" EXACT RESID-alternate [] synonym: "2-pyrrolidone-5-carboxylic acid" EXACT RESID-name [] synonym: "5-oxoproline" EXACT RESID-alternate [] synonym: "5-oxopyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] synonym: "5-pyrrolidone-2-carboxylic acid" EXACT RESID-alternate [] synonym: "Glu->pyro-Glu" RELATED PSI-MS-label [] synonym: "MOD_RES Pyrrolidone carboxylic acid (Glu)" EXACT UniProt-feature [] synonym: "ntermpeppyroe" EXACT OMSSA-label [] synonym: "PCA" EXACT RESID-alternate [] synonym: "PyrGlu(Glu)" EXACT PSI-MOD-label [] synonym: "Pyro-glu from E" RELATED UniMod-description [] synonym: "pyroglutamic acid" EXACT RESID-alternate [] synonym: "Pyroglutamic Acid formed from Glutamic Acid" EXACT DeltaMass-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 5 H 6 N 1 O 2" xref: MassAvg: "112.11" xref: MassMono: "112.039853" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid [Term] id: MOD:00421 name: C-glycosylated residue def: "A protein modification that effectively replaces a residue hydrogen atom on a carbon with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "CGlycoRes" EXACT PSI-MOD-label [] is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00422 name: alpha-amino morpholine-2-acetylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a morpholine-2-acetyl group." [PubMed:10446193, UniMod:29#N-term] comment: The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. synonym: "N-Succinimidyl-2-morpholine acetate" RELATED UniMod-description [] synonym: "N-succinimidylmorpholine-2-acetate alpha-amino derivative" EXACT PSI-MOD-alternate [] synonym: "SMA" RELATED PSI-MS-label [] xref: DiffAvg: "127.14" xref: DiffFormula: "C 6 H 9 N 1 O 2" xref: DiffMono: "127.063329" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01696 ! alpha-amino acylated residue is_a: MOD:01813 ! morpholine-2-acetylated residue [Term] id: MOD:00423 name: monosodium salt def: "A protein modification that effectively substitutes one sodium atom for one hydrogen atom." [DeltaMass:0, UniMod:30] subset: PSI-MOD-slim synonym: "Cation:Na" RELATED PSI-MS-label [] synonym: "Na1Res" EXACT PSI-MOD-label [] synonym: "Sodium" EXACT DeltaMass-label [] synonym: "Sodium adduct" RELATED UniMod-description [] xref: DiffAvg: "21.98" xref: DiffFormula: "H -1 Na 1" xref: DiffMono: "21.981944" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00747 ! sodium containing modified residue [Term] id: MOD:00424 name: S-pyridylethyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-pyridylethyl-L-cysteine." [DeltaMass:253, OMSSA:112, PubMed:11760118, PubMed:626389, PubMed:8297018, PubMed:8783016, UniMod:31#C] comment: From DeltaMass: Formula:C10H12O2N1S1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:208.067 Average Mass Change:208.286 (mass incorrect, aggregate not delta) References:PE Sciex synonym: "PECys" EXACT DeltaMass-label [] synonym: "Pyridylethyl" RELATED PSI-MS-label [] synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label [] synonym: "S-pyridinylethyl-L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S-pyridylethylation" RELATED UniMod-description [] synonym: "spyridylethylc" EXACT OMSSA-label [] synonym: "vinylpyridine derivatized cysteine residue" EXACT PSI-MOD-alternate [] xref: DiffAvg: "105.14" xref: DiffFormula: "C 7 H 7 N 1" xref: DiffMono: "105.057849" xref: Formula: "C 10 H 12 N 2 O 1 S 1" xref: MassAvg: "208.28" xref: MassMono: "208.067034" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00425 name: monohydroxylated residue def: "A protein modification that effectively replaces one hydrogen atom with a hydroxyl group." [UniMod:35] subset: PSI-MOD-slim synonym: "Hy1Res" EXACT PSI-MOD-label [] synonym: "Oxidation" RELATED UniMod-interim [] synonym: "Oxidation or Hydroxylation" RELATED UniMod-description [] xref: DiffAvg: "16.00" xref: DiffFormula: "O 1" xref: DiffMono: "15.994915" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "C-term" is_a: MOD:00677 ! hydroxylated residue [Term] id: MOD:00426 name: S-glycosylated residue def: "A protein modification that effectively replaces a residue hydrogen atom on a sulfur with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235] synonym: "SGlycoRes" EXACT PSI-MOD-label [] is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00427 name: methylated residue def: "A protein modification that effectively replaces a hydrogen atom with a methyl group." [DeltaMass:36] comment: From DeltaMass: Average Mass: 14 Average Mass Change:14 References:Methylation of Asparagine (found in phycobiliproteins) Klotz and Glazer (1987) J. Biol. Chem. 262; 17350-17355 subset: PSI-MOD-slim synonym: "MeRes" EXACT PSI-MOD-label [] synonym: "Methylation (N terminus, N epsilon of Lysine, O of Serine, Threonine or C terminus, N of Asparagine)" EXACT DeltaMass-label [] is_a: MOD:00001 ! alkylated residue [Term] id: MOD:00428 name: dihydroxylated residue def: "A protein modification that effectively replaces two hydrogen atoms with two hydroxyl groups." [PubMed:12686488, UniMod:425] subset: PSI-MOD-slim synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] synonym: "Hy2Res" EXACT PSI-MOD-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue [Term] id: MOD:00429 name: dimethylated residue def: "A protein modification that effectively replaces two hydrogen atoms with two methyl groups." [DeltaMass:0, PubMed:12964758, PubMed:14570711, UniMod:36] comment: For amino-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts only for dimethylation and not protonation. The alternative Me2+Res process accounts for both protonation and dimethylation [JSG]. subset: PSI-MOD-slim synonym: "di-Methylation" RELATED UniMod-description [] synonym: "Dimethyl" RELATED PSI-MS-label [] synonym: "Me2Res" EXACT PSI-MOD-label [] synonym: "N,N dimethylation (of Arginine or Lysine)" EXACT DeltaMass-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue [Term] id: MOD:00430 name: trimethylated residue def: "A protein modification that effectively replaces three hydrogen atoms with three methyl groups." [PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, UniMod:37] comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative Me3+Res process accounts for both protonation and trimethylation. subset: PSI-MOD-slim synonym: "Me3Res" EXACT PSI-MOD-label [] synonym: "tri-Methylation" RELATED UniMod-description [] synonym: "Trimethyl" RELATED PSI-MS-label [] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6" xref: DiffMono: "42.046950" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue [Term] id: MOD:00431 name: modified residue with a secondary neutral loss def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral molecular fragment." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NLModRes" EXACT PSI-MOD-label [] is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00432 name: modified residue with neutral loss of phosphate def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235] subset: PSI-MOD-slim synonym: "dPhosModRes" EXACT PSI-MOD-label [] is_a: MOD:00431 ! modified residue with a secondary neutral loss [Term] id: MOD:00433 name: glucosylated residue def: "A protein modification that effectively replaces a hydrogen atom with an glucose group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "GlcRes" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00434 ! hexosylated residue is_a: MOD:00726 ! glucosylated [Term] id: MOD:00434 name: hexosylated residue def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexose sugar group through a glycosidic bond." [DeltaMass:203, PubMed:15279557, UniMod:41] comment: From DeltaMass: Average Mass: 162 Formula:C6 H10 05 Monoisotopic Mass Change:162.053 Average Mass Change:162.143 References:PE Sciex. subset: PSI-MOD-slim synonym: "Hex" EXACT PSI-MOD-label [] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] synonym: "Hexoses (Fru, Gal, Glc, Man)" EXACT DeltaMass-label [] synonym: "O-Glycosyl-" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00435 name: O-phospho-L-serine with neutral loss of phosphate def: "Covalent modification of a peptide or protein amino acid phosphorylated serine with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235] subset: PSI-MOD-slim synonym: "dPhosOPhosSer" EXACT PSI-MOD-label [] xref: DiffAvg: "-97.99" xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1" xref: DiffMono: "-97.976895" xref: Formula: "C 3 H 3 N 1 O 1" xref: MassAvg: "69.06" xref: MassMono: "69.021464" xref: Origin: "MOD:00046" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01151 ! phosphorylated residue with neutral loss of phosphate relationship: derives_from MOD:00046 ! O-phospho-L-serine [Term] id: MOD:00436 name: N-acetylhexosaminylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylhexosamine group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "HexNAc" EXACT PSI-MOD-label [] synonym: "N-Acetylhexosamine" RELATED UniMod-description [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00437 name: farnesylated residue def: "A protein modification that effectively replaces a hydrogen atom with a farnesyl group." [DeltaMass:0, PubMed:15609361, UniMod:44] comment: From DeltaMass: Average Mass: 204 subset: PSI-MOD-slim synonym: "Farnesyl" RELATED PSI-MS-label [] synonym: "Farnesylation" EXACT DeltaMass-label [] synonym: "Farnesylation" RELATED UniMod-description [] synonym: "FarnRes" EXACT PSI-MOD-label [] xref: DiffAvg: "204.36" xref: DiffFormula: "C 15 H 24" xref: DiffMono: "204.187801" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00703 ! isoprenylated residue [Term] id: MOD:00438 name: myristoylated residue def: "A protein modification that effectively replaces a hydrogen atom with a myristoyl group." [DeltaMass:0, UniMod:45] comment: From DeltaMass: Average Mass: 210 subset: PSI-MOD-slim synonym: "C14:0 aliphatic acylated residue" EXACT PSI-MOD-alternate [] synonym: "Myristoyl" RELATED PSI-MS-label [] synonym: "Myristoylation" EXACT DeltaMass-label [] synonym: "Myristoylation" RELATED UniMod-description [] synonym: "MyrRes" EXACT PSI-MOD-label [] xref: DiffAvg: "210.36" xref: DiffFormula: "C 14 H 26 O 1" xref: DiffMono: "210.198365" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00439 name: O-phospho-L-threonine with neutral loss of phosphate def: "Covalent modification of a peptide or protein amino acid phosphorylated threonine with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235] subset: PSI-MOD-slim synonym: "dPhosOPhosThr" EXACT PSI-MOD-label [] xref: DiffAvg: "-97.99" xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1" xref: DiffMono: "-97.976895" xref: Formula: "C 4 H 5 N 1 O 1" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "MOD:00047" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01151 ! phosphorylated residue with neutral loss of phosphate relationship: derives_from MOD:00047 ! O-phospho-L-threonine [Term] id: MOD:00440 name: palmitoylated residue def: "A protein modification that effectively replaces a hydrogen atom with a palmitoyl group." [DeltaMass:0] comment: From DeltaMass: Average Mass: 238 subset: PSI-MOD-slim synonym: "Palmitoyl" RELATED PSI-MS-label [] synonym: "Palmitoylation" EXACT DeltaMass-label [] synonym: "Palmitoylation" RELATED UniMod-description [] synonym: "PamRes" EXACT PSI-MOD-label [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 O 1" xref: DiffMono: "238.229666" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00441 name: geranylgeranylated residue def: "A protein modification that effectively replaces a hydrogen atom with a geranylgeranyl group." [DeltaMass:0, PubMed:15609361, UniMod:48] comment: From DeltaMass: Average Mass: 272 subset: PSI-MOD-slim synonym: "Geranyl-geranyl" RELATED UniMod-description [] synonym: "GeranylGeranyl" RELATED PSI-MS-label [] synonym: "Geranylgeranylation" EXACT DeltaMass-label [] synonym: "GergerRes" EXACT PSI-MOD-label [] xref: DiffAvg: "272.48" xref: DiffFormula: "C 20 H 32" xref: DiffMono: "272.250401" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00703 ! isoprenylated residue [Term] id: MOD:00442 name: protonated omega-N,omega-N'-dimethylated L-arginine with secondary neutral loss of N,N'-carbodiimide def: "Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N'-dimethylated L-arginine with secondary loss of an N,N'-carbodiimide molecular fragment." [PubMed:15835918, PubMed:18688235] synonym: "dCDI-NNMe2+Arg" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 1 H 2 N 2 O 0" xref: DiffMono: "42.021798" xref: Formula: "C 7 H 14 N 2 O 1" xref: MassAvg: "142.20" xref: MassMono: "142.110613" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00431 ! modified residue with a secondary neutral loss is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00443 name: protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of N,N-dimethylamine def: "Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of an N,N-dimethylamine molecular fragment." [PubMed:15835918, PubMed:18688235] synonym: "dDMA-NoMe2+Arg" EXACT PSI-MOD-label [] xref: DiffAvg: "59.09" xref: DiffFormula: "C 2 H 7 N 2" xref: DiffMono: "59.060923" xref: Formula: "C 6 H 10 N 3 O 1" xref: MassAvg: "140.17" xref: MassMono: "140.082387" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00431 ! modified residue with a secondary neutral loss is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00444 name: N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine." [OMSSA:118, PubMed:10356335, UniMod:51] synonym: "N-acyl diglyceride cysteine" RELATED UniMod-description [] synonym: "ntermpeptripalmitatec" EXACT OMSSA-label [] synonym: "Tripalmitate" RELATED PSI-MS-label [] xref: DiffAvg: "789.32" xref: DiffFormula: "C 51 H 96 O 5" xref: DiffMono: "788.725776" xref: Formula: "C 54 H 101 N 1 O 6 S 1" xref: MassAvg: "892.46" xref: MassMono: "891.734961" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00899 ! N-palmitoyl-S-diacylglycerol-L-cysteine relationship: has_functional_parent MOD:01144 ! S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine [Term] id: MOD:00445 name: L-homoarginine def: "A protein modification that effectively converts an L-lysine residue to L-homoarginine, such as reaction with O-methylisourea." [OMSSA:53, PubMed:11078590, PubMed:11085420, PubMed:11821862, UniMod:52] subset: PSI-MOD-slim synonym: "Guanidination" RELATED UniMod-description [] synonym: "guanidinationk" EXACT OMSSA-label [] synonym: "Guanidinyl" RELATED PSI-MS-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 1 H 2 N 2" xref: DiffMono: "42.021798" xref: Formula: "C 7 H 14 N 4 O 1" xref: MassAvg: "170.22" xref: MassMono: "170.116761" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00446 name: 4-hydroxynonenal adduct def: "A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, UniMod:53] comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. synonym: "4-hydroxynonenal (HNE)" RELATED UniMod-description [] synonym: "HNE" RELATED PSI-MS-label [] xref: DiffAvg: "156.22" xref: DiffFormula: "C 9 H 16 O 2" xref: DiffMono: "156.115030" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00447 name: N-glucuronylated residue def: "A protein modification that effectively results from forming an adduct with a glucuronic acid either through a carboxyl group amide or ester bond, or through C1-glycosylation." [DeltaMass:0, PubMed:7398618, UniMod:54#N-term] subset: PSI-MOD-slim synonym: "Glucuronyl" RELATED PSI-MS-label [] synonym: "N-Glucuronyl (N terminus)" EXACT DeltaMass-label [] synonym: "N-glucuronylation" RELATED UniMod-description [] xref: DiffAvg: "176.12" xref: DiffFormula: "C 6 H 8 O 6" xref: DiffMono: "176.032088" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00764 ! glycoconjugated residue [Term] id: MOD:00448 name: N-acetylaminoglucosylated residue def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminoglucose group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "GlcNAcRes" EXACT PSI-MOD-label [] synonym: "HexNAc" RELATED PSI-MS-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00733 ! N-acetylaminoglucosylated is_a: MOD:01673 ! N-acetylaminohexosylated residue [Term] id: MOD:00449 name: acetate labeling reagent (N-term) (heavy form, +3amu) def: "modification from UniMod Isotopic label" [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:56] synonym: "Acetate labeling reagent (N-term & K) (heavy form, +3amu)" RELATED UniMod-description [] synonym: "Acetyl:2H(3)" RELATED PSI-MS-label [] xref: DiffAvg: "45.03" xref: DiffFormula: "C 2 (1)H -1 (2)H 3 O 1" xref: DiffMono: "45.029395" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01431 ! (2)H deuterium tagged reagent [Term] id: MOD:00450 name: acetate labeling reagent light form (K) def: "OBSOLETE because this isotopic label from UniMod entry 57 is deprecated" [PubMed:11857757] xref: DiffAvg: "42.01" xref: DiffFormula: "C 2 (1)H 2 O 1" xref: DiffMono: "42.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00451 name: alpha-amino propanoylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:58#N-term] synonym: "Propionate labeling reagent light form (N-term & K)" RELATED UniMod-description [] synonym: "Propionyl" RELATED PSI-MS-label [] xref: DiffAvg: "56.06" xref: DiffFormula: "C 3 H 4 O 1" xref: DiffMono: "56.026215" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01894 ! propanoylated residue [Term] id: MOD:00452 name: alpha-amino 3x(13)C-labeled propanoylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(13)C-labeled propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:59#N-term] synonym: "Propionate labeling reagent heavy form (+3amu), N-term & K" RELATED UniMod-description [] synonym: "Propionyl:13C(3)" RELATED PSI-MS-label [] xref: DiffAvg: "59.04" xref: DiffFormula: "(13)C 3 H 4 O 1" xref: DiffMono: "59.036279" xref: Formula: "(12)C 6 (13)C 3 H 16 N 2 O 2" xref: MassAvg: "187.13" xref: MassMono: "187.131242" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00451 ! alpha-amino propanoylated residue [Term] id: MOD:00453 name: quaternary amine labeling reagent light form (N-term & K) def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent light form group." [PubMed:11857757, UniMod:60] synonym: "GIST-Quat" RELATED PSI-MS-label [] synonym: "Quaternary amine labeling reagent light form (N-term & K)" RELATED UniMod-description [] xref: DiffAvg: "127.19" xref: DiffFormula: "C 7 H 13 N 1 O 1" xref: DiffMono: "127.099714" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00454 name: quaternary amine labeling reagent heavy form (+3amu) (N-term & K) def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+3amu) form group." [PubMed:11857757, UniMod:61] synonym: "GIST-Quat:2H(3)" RELATED PSI-MS-label [] synonym: "Quaternary amine labeling reagent heavy (+3amu) form, N-term & K" RELATED UniMod-description [] xref: DiffAvg: "130.12" xref: DiffFormula: "C 7 (1)H 10 (2)H 3 N 1 O 1" xref: DiffMono: "130.118544" xref: Formula: "C 13 (1)H 22 (2)H 3 N 3 O 2" xref: MassAvg: "258.21" xref: MassMono: "258.213507" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00455 name: quaternary amine labeling reagent heavy form (+6amu) (N-term & K) def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+6amu) form group." [PubMed:11857757, UniMod:62] synonym: "GIST-Quat:2H(6)" RELATED PSI-MS-label [] synonym: "Quaternary amine labeling reagent heavy form (+6amu), N-term & K" RELATED UniMod-description [] xref: DiffAvg: "133.14" xref: DiffFormula: "C 7 H 7 (2)H 6 N 1 O 1" xref: DiffMono: "133.137375" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00456 name: quaternary amine labeling reagent heavy form (+9amu) (N-term & K) def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+9amu) form group." [PubMed:11857757, UniMod:63] synonym: "GIST-Quat:2H(9)" RELATED PSI-MS-label [] synonym: "Quaternary amine labeling reagent heavy form (+9amu), N-term & K" RELATED UniMod-description [] xref: DiffAvg: "136.16" xref: DiffFormula: "C 7 (1)H 4 (2)H 9 N 1 O 1" xref: DiffMono: "136.156205" xref: Formula: "C 13 (1)H 16 (2)H 9 N 3 O 2" xref: MassAvg: "264.25" xref: MassMono: "264.251168" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00457 name: alpha-amino succinylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a succinyl group." [PubMed:11857757, PubMed:12175151, UniMod:64#N-term] synonym: "Succinic anhydride labeling reagent light form (N-term)" RELATED UniMod-description [] synonym: "Succinyl" RELATED PSI-MS-label [] xref: DiffAvg: "100.02" xref: DiffFormula: "(12)C 4 (1)H 4 O 3" xref: DiffMono: "100.016044" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:01029 ! succinylated residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:00458 name: 4x(2)H labeled alpha-amino succinylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(2)H labeled succinyl group." [PubMed:11857757, PubMed:12175151, UniMod:65#N-term] synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term" RELATED UniMod-description [] synonym: "Succinyl:2H(4)" RELATED PSI-MS-label [] xref: DiffAvg: "104.04" xref: DiffFormula: "C 4 (2)H 4 O 3" xref: DiffMono: "104.041151" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00457 ! alpha-amino succinylated residue [Term] id: MOD:00459 name: 4x(13)C labeled alpha-amino succinylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(13)C labeled succinyl group." [PubMed:11857757, PubMed:12175151, UniMod:66#N-term] synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), N-term & K" RELATED UniMod-description [] synonym: "Succinyl:13C(4)" RELATED PSI-MS-label [] xref: DiffAvg: "104.03" xref: DiffFormula: "(13)C 4 H 4 O 3" xref: DiffMono: "104.029463" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00457 ! alpha-amino succinylated residue [Term] id: MOD:00460 name: L-cysteic acid (L-cysteine sulfonic acid) def: "A protein modification that effectively trioxygenates an L-cysteine residue to L-cysteine sulfonic acid." [ChEBI:17285, DeltaMass:334, OMSSA:34, PubMed:14678012, PubMed:18306178, PubMed:19522542, PubMed:9252331, RESID:AA0556, UniMod:345#C] comment: From DeltaMass: Notes:Treatment of cysteine by strongly oxidising reagents such as performic acid results in the complete oxidation of the sulphur atom. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. subset: PSI-MOD-slim synonym: "(2R)-2-amino-3-sulfopropanoic acid" EXACT RESID-systematic [] synonym: "2-amino-2-carboxyethanesulfonic acid" EXACT RESID-alternate [] synonym: "2-azanyl-3-sulfopropanoic acid" EXACT RESID-alternate [] synonym: "3-sulfoalanine" EXACT RESID-alternate [] synonym: "Cya" EXACT DeltaMass-label [] synonym: "CysO3H" EXACT PSI-MOD-label [] synonym: "cysteic acid" EXACT RESID-alternate [] synonym: "Cysteic acid, oxidation of cysteine" EXACT DeltaMass-label [] synonym: "cysteicacidc" EXACT OMSSA-label [] synonym: "cysteine oxidation to cysteic acid" RELATED UniMod-description [] synonym: "cysteine sulphonic acid" EXACT RESID-alternate [] synonym: "L-cysteine sulfonic acid" EXACT RESID-name [] synonym: "Trioxidation" RELATED PSI-MS-label [] xref: DiffAvg: "48.00" xref: DiffFormula: "C 0 H 0 N 0 O 3 S 0" xref: DiffMono: "47.984744" xref: Formula: "C 3 H 5 N 1 O 4 S 1" xref: MassAvg: "151.14" xref: MassMono: "150.993929" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00708 ! sulfur oxygenated L-cysteine [Term] id: MOD:00461 name: nitrosylation def: "A protein modification that effectively substitutes a nitrite (NO2) group for a hydrogen atom." [DeltaMass:0, PubMed:8839040, PubMed:9252331, UniMod:354] comment: Note, this is often misrepresented as the introduction of a nitrate (NO3) group [JSG]. subset: PSI-MOD-slim synonym: "Nitro" RELATED PSI-MS-label [] synonym: "Nitro (NO2)" EXACT DeltaMass-label [] synonym: "Oxidation to nitro" RELATED UniMod-description [] xref: DiffAvg: "45.00" xref: DiffFormula: "H -1 N 1 O 2" xref: DiffMono: "44.985078" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00462 name: L-kynurenine def: "A protein modification that effectively converts an L-tryptophan residue to L-kynurenine." [DeltaMass:357, OMSSA:66, PubMed:11029593, PubMed:9252331, UniMod:351#W] subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-(2-aminophenyl)-4-oxo-butanoic acid" EXACT PSI-MOD-alternate [] synonym: "kynureninw" EXACT OMSSA-label [] synonym: "Trp->Kynurenin" RELATED PSI-MS-label [] synonym: "tryptophan oxidation to kynurenin" RELATED UniMod-description [] xref: DiffAvg: "3.99" xref: DiffFormula: "C -1 O 1" xref: DiffMono: "3.994915" xref: Formula: "C 10 H 10 N 2 O 2" xref: MassAvg: "190.20" xref: MassMono: "190.074228" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00463 name: 3'-hydroxy-L-kynurenine def: "A protein modification that effectively converts an L-tryptophan residue to 3'-hydroxy-L-kynurenine." [OMSSA:58, PubMed:9252331, UniMod:350#W] subset: PSI-MOD-slim synonym: "hydroxykynureninw" EXACT OMSSA-label [] synonym: "Trp->Hydroxykynurenin" RELATED PSI-MS-label [] synonym: "tryptophan oxidation to hydroxykynurenin" RELATED UniMod-description [] xref: DiffAvg: "19.99" xref: DiffFormula: "C -1 O 2" xref: DiffMono: "19.989829" xref: Formula: "C 10 H 10 N 2 O 3" xref: MassAvg: "206.20" xref: MassMono: "206.069142" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00464 name: N'-formyl-L-kynurenine def: "A protein modification that effectively converts an L-tryptophan residue to N'-formyl-L-kynurenine." [DeltaMass:356, OMSSA:45, PubMed:12124932, PubMed:12686488, PubMed:9252331, UniMod:425#W] comment: From DeltaMass: References:Willy V. Bienvenut, Catherine Déon, Carla Pasquarello, Jennifer M. Campbell, Jean-Charles Sanchez, Marvin L. Vestal, Denis F. Hochstrasser Matrix-assisted laser desorption/ionization-tandemmass spectrometry with high resolution andsensitivity for identification and characterizationof proteins. Proteomics 2002, 2, 868-876 Notes: A double oxidation of tryptophan for which the N-formylkynurenine (+32) structure can be proposed. Many minor peaks accompanying the main peak might also be attributed to other oxidation products of the tryptophan such as kynurenine (+4), an unknown by-product found in all oxidized tryptophan patterns (+13), hydroxytryptophan (+16), 3-hydroxykynurenine (+20) and hydroxy-N-formylkynurenine (+48). See proposed structures at http://www.abrf.org/images/misc/dmass32.jpg. subset: PSI-MOD-slim synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] synonym: "Double oxidation of Trp" EXACT DeltaMass-label [] synonym: "formylkynureninw" EXACT OMSSA-label [] synonym: "tryptophan oxidation to formylkynurenin" RELATED UniMod-alternate [] xref: DiffAvg: "32.00" xref: DiffFormula: "O 2" xref: DiffMono: "31.989829" xref: Formula: "C 11 H 10 N 2 O 3" xref: MassAvg: "218.21" xref: MassMono: "218.069142" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00465 name: dihydroxyphenylalanine (Phe) def: "A protein modification that effectively converts an L-phenylalanine residue to a dihydroxyphenylalanine." [OMSSA:39, PubMed:1610822, PubMed:1903612, PubMed:3734192, PubMed:9252331, RESID:AA0146#var, UniMod:425#F] comment: Dihydroxyphenyalanines with a 4'-hydroxyl orginate naturally by a monohydroxylation of tyrosine, and not by dihydroxylation of phenylalanine [JSG]. subset: PSI-MOD-slim synonym: "dihydroxy" RELATED UniMod-description [] synonym: "dihydroxyf" EXACT OMSSA-label [] synonym: "Dioxidation" RELATED PSI-MS-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "O 2" xref: DiffMono: "31.989829" xref: Formula: "C 9 H 9 N 1 O 3" xref: MassAvg: "179.17" xref: MassMono: "179.058243" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00428 ! dihydroxylated residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:00466 name: glycosylsphingolipidinositolated residue def: "A protein modification that effectively converts a residue to a glycosylsphingolipidinositolethanolamidated." [PubMed:12626404, PubMed:18688235, PubMed:8404891] synonym: "GSIRes" EXACT PSI-MOD-label [] is_a: MOD:00764 ! glycoconjugated residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00467 name: iminobiotinyl modified residue def: "A protein modification that effectively substitutes an iminobiotinyl group for a hydrogen atom." [PubMed:9750125, UniMod:89] synonym: "Iminobiotin" RELATED PSI-MS-label [] synonym: "Iminobiotinylation" RELATED UniMod-description [] xref: DiffAvg: "225.31" xref: DiffFormula: "C 10 H 15 N 3 O 1 S 1" xref: DiffMono: "225.093583" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00468 name: ESP-Tag light d0 def: "modification from UniMod Isotopic label" [UniMod:90] synonym: "ESP" RELATED PSI-MS-label [] synonym: "ESP-Tag light d0" RELATED UniMod-description [] xref: DiffAvg: "338.47" xref: DiffFormula: "C 16 H 26 N 4 O 2 S 1" xref: DiffMono: "338.177647" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00469 name: ESP-Tag heavy d10 def: "modification from UniMod Isotopic label" [UniMod:91] synonym: "ESP-Tag heavy d10" RELATED UniMod-description [] synonym: "ESP:2H(10)" RELATED PSI-MS-label [] xref: DiffAvg: "348.24" xref: DiffFormula: "C 16 (1)H 16 (2)H 10 N 4 O 2 S 1" xref: DiffMono: "348.240415" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01431 ! (2)H deuterium tagged reagent [Term] id: MOD:00470 name: NHS-LC-Biotin def: "modification from UniMod Chemical derivative" [UniMod:92] synonym: "NHS-LC-Biotin" RELATED UniMod-interim [] synonym: "NHS-LC-Biotin" RELATED UniMod-description [] xref: DiffAvg: "339.45" xref: DiffFormula: "C 16 H 25 N 3 O 3 S 1" xref: DiffMono: "339.161663" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00471 name: EDT-maleimide-PEO-biotin def: "modification from UniMod Chemical derivative" [UniMod:93] synonym: "EDT-maleimide-PEO-biotin" RELATED UniMod-interim [] synonym: "EDT-maleimide-PEO-biotin" RELATED UniMod-description [] xref: DiffAvg: "601.80" xref: DiffFormula: "C 25 H 39 N 5 O 6 S 3" xref: DiffMono: "601.206247" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00472 name: IMID d0 def: "modification from UniMod Isotopic label" [PubMed:11746907, UniMod:94, URL:http\://dx.doi.org/10.1002/rcm.517] synonym: "IMID" RELATED PSI-MS-label [] synonym: "IMID d0" RELATED UniMod-description [] xref: DiffAvg: "68.04" xref: DiffFormula: "C 3 (1)H 4 N 2" xref: DiffMono: "68.037448" xref: Formula: "C 9 H 16 N 4 O 1" xref: MassAvg: "196.13" xref: MassMono: "196.132411" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00473 name: IMID d4 def: "modification from UniMod Isotopic label" [PubMed:11746907, UniMod:95, URL:http\://dx.doi.org/10.1002/rcm.517] synonym: "IMID d4" RELATED UniMod-description [] synonym: "IMID:2H(4)" RELATED PSI-MS-label [] xref: DiffAvg: "72.06" xref: DiffFormula: "C 3 (2)H 4 N 2" xref: DiffMono: "72.062555" xref: Formula: "C 9 (1)H 12 (2)H 4 N 4 O 1" xref: MassAvg: "200.16" xref: MassMono: "200.157518" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00474 name: S-([1,1,2-(2)H3]-carboxamidoethyl)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(1,1,2-(2)H3)-propanamide-L-cysteine." [UniMod:97#C] synonym: "Acrylamide d3" RELATED UniMod-description [] synonym: "Propionamide:2H(3)" RELATED PSI-MS-label [] synonym: "S-([1,1,2-(2)H3]-3-amino-3-oxopropyl)cysteine" EXACT PSI-MOD-alternate [] synonym: "S-([1,1,2-(2)H3]-carbamoylethyl)-L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S-([1,1,2-(2)H3]-propanamide)-L-cysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "74.06" xref: DiffFormula: "C 3 (1)H 2 (2)H 3 N 1 O 1" xref: DiffMono: "74.055944" xref: Formula: "C 6 (1)H 7 (2)H 3 N 2 O 2 S 1" xref: MassAvg: "177.07" xref: MassMono: "177.065129" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00417 ! S-carboxamidoethyl-L-cysteine is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00475 name: tyrosine oxidation to 2-aminotyrosine def: "modification from UniMod Chemical derivative" [PubMed:8839040, PubMed:9252331, UniMod:342#Y] comment: May be misdescribed. Name (if not misdescribed) should be 2'-aminotyrosine [JSG]. synonym: "Amino" RELATED PSI-MS-label [] synonym: "Tyrosine oxidation to 2-aminotyrosine" RELATED UniMod-description [] xref: DiffAvg: "15.02" xref: DiffFormula: "H 1 N 1" xref: DiffMono: "15.010899" xref: Formula: "C 9 H 10 N 2 O 2" xref: MassAvg: "178.19" xref: MassMono: "178.074228" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00476 name: galactosylated residue def: "A protein modification that effectively replaces a hydrogen atom with an galactose group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "GalRes" EXACT PSI-MOD-label [] is_a: MOD:00434 ! hexosylated residue is_a: MOD:00728 ! galactosylated [Term] id: MOD:00477 name: 2-pyrrolidone def: "A protein modification that effectively converts, by oxidative decarboxylation, an L-proline residue to 2-pyrrolidone with breakage of the peptide chain." [PubMed:2161657, PubMed:9252331, UniMod:360#P] comment: The oxidative decarboxylation of a proline residue results in breaking of the peptide chain, leaving a peptidyl-2-pyrrolidone at the C-terminus. The difference formula, derived from the result in the original citation, has been corrected from the UniMod entry. synonym: "Pro->Pyrrolidinone" RELATED PSI-MS-label [] synonym: "Proline oxidation to pyrrolidinone" RELATED UniMod-description [] xref: DiffAvg: "-13.02" xref: DiffFormula: "C -1 H -1 N 0 O 0" xref: DiffMono: "-13.007825" xref: Formula: "C 4 H 6 N 1 O 1" xref: MassAvg: "84.10" xref: MassMono: "84.044939" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00683 ! dehydrogenated residue is_a: MOD:00915 ! modified L-proline residue is_a: MOD:00960 ! decarboxylated residue [Term] id: MOD:00478 name: glutamyl semialdehyde (Pro) def: "A protein modification that effectively converts an L-proline residue to L-glutamyl semialdehyde." [DeltaMass:354, PubMed:11120890, PubMed:2563380, PubMed:9252331, UniMod:35#P] synonym: "gamma-glutamyl semialdehyde" EXACT PSI-MOD-alternate [] synonym: "glutamyl 5-semialdehyde" EXACT PSI-MOD-alternate [] synonym: "glutamyl aldehyde" EXACT PSI-MOD-alternate [] synonym: "Oxidation" RELATED UniMod-interim [] synonym: "Oxidation of proline to gamma-glutamyl semialdehyde" EXACT DeltaMass-label [] synonym: "Oxidation or Hydroxylation" RELATED UniMod-description [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 7 N 1 O 2" xref: MassAvg: "113.12" xref: MassMono: "113.047678" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01440 ! glutamyl semialdehyde [Term] id: MOD:00479 name: glutamyl semialdehyde (Arg) def: "A protein modification that effectively converts an L-arginine residue to L-glutamyl semialdehyde." [DeltaMass:351, PubMed:11120890, PubMed:1680314, PubMed:9252331, UniMod:344#R] comment: From DeltaMass: Average Mass: -27 Monoisotopic Mass Change:-27.06 Average Mass Change:-27.07 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. synonym: "Arg->GluSA" RELATED PSI-MS-label [] synonym: "Arginine oxidation to glutamic semialdehyde" RELATED UniMod-description [] synonym: "Oxidation of arginine (to glutamic acid)" EXACT DeltaMass-label [] xref: DiffAvg: "-43.07" xref: DiffFormula: "C -1 H -5 N -3 O 1" xref: DiffMono: "-43.053433" xref: Formula: "C 5 H 7 N 1 O 2" xref: MassAvg: "113.12" xref: MassMono: "113.047678" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:01440 ! glutamyl semialdehyde [Term] id: MOD:00480 name: Applied Biosystems cleavable ICAT(TM) light def: "modification from UniMod Isotopic label" [OMSSA:129, UniMod:105#C, URL:http\://www.appliedbiosystems.com/products/productdetail.cfm?prod_id=153] subset: PSI-MOD-slim synonym: "Applied Biosystems cleavable ICAT(TM) light" RELATED UniMod-description [] synonym: "ICAT-C" RELATED PSI-MS-label [] synonym: "icatlight" EXACT OMSSA-label [] xref: DiffAvg: "227.26" xref: DiffFormula: "C 10 H 17 N 3 O 3" xref: DiffMono: "227.126991" xref: Formula: "C 13 H 22 N 4 O 4 S 1" xref: MassAvg: "330.40" xref: MassMono: "330.136176" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00481 name: Applied Biosystems cleavable ICAT(TM) heavy def: "modification from UniMod Isotopic label" [OMSSA:130, UniMod:106#C, URL:http\://www.appliedbiosystems.com/products/productdetail.cfm?prod_id=153] subset: PSI-MOD-slim synonym: "Applied Biosystems cleavable ICAT(TM) heavy" RELATED UniMod-description [] synonym: "ICAT-C:13C(9)" RELATED PSI-MS-label [] synonym: "icatheavy" EXACT OMSSA-label [] xref: DiffAvg: "236.16" xref: DiffFormula: "(12)C 1 (13)C 9 H 17 N 3 O 3" xref: DiffMono: "236.157185" xref: Formula: "(12)C 4 (13)C 9 H 22 N 4 O 4 S 1" xref: MassAvg: "339.17" xref: MassMono: "339.166370" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent [Term] id: MOD:00482 name: N-formyl-L-methionine (Met) def: "A protein modification that effectively converts an L-methionine residue to N-formyl-L-methionine (not known as a natural, post-translational modification process)." [PubMed:11152118, PubMed:2165784, PubMed:3042771, RESID:AA0021#MET] comment: This entry is for the artifactual formation of N-formyl-L-methionine from methionine. For encoded N-formyl-L-methionine, use MOD:00030 [JSG]. synonym: "(2S)-2-formylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-formamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "2-formylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate [] synonym: "2-formylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N-formylmethionine" EXACT UniProt-feature [] synonym: "N-formyl-L-methionine" EXACT RESID-name [] synonym: "N-formylated L-methionine" EXACT PSI-MOD-alternate [] synonym: "NFoMet" EXACT PSI-MOD-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1 S 0" xref: DiffMono: "27.994915" xref: Formula: "C 6 H 10 N 1 O 2 S 1" xref: MassAvg: "160.21" xref: MassMono: "160.043225" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00030 ! N-formyl-L-methionine residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00483 name: N-ethylmaleimide derivatized cysteine def: "A protein modification that is produced by reaction with N-ethylmaleimide." [OMSSA:83, PubMed:11813307, PubMed:12777388, UniMod:108#C] synonym: "N-ethylmaleimide on cysteines" RELATED UniMod-description [] synonym: "nemc" EXACT OMSSA-label [] synonym: "Nethylmaleimide" RELATED PSI-MS-label [] xref: DiffAvg: "125.13" xref: DiffFormula: "C 6 H 7 N 1 O 2" xref: DiffMono: "125.047678" xref: Formula: "C 9 H 12 N 2 O 3 S 1" xref: MassAvg: "228.27" xref: MassMono: "228.056863" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00484 name: oxidized lysine biotinylated with biotin-LC-hydrazide, reduced def: "modification from UniMod Chemical derivative" [UniMod:112#K] synonym: "Oxidized lysine biotinylated with biotin-LC-hydrazide, reduced" RELATED UniMod-description [] synonym: "OxLysBiotinRed" RELATED UniMod-interim [] xref: DiffAvg: "354.47" xref: DiffFormula: "C 16 H 26 N 4 O 3 S 1" xref: DiffMono: "354.172562" xref: Formula: "C 22 H 38 N 6 O 4 S 1" xref: MassAvg: "482.64" xref: MassMono: "482.267525" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00485 name: oxidized lysine biotinylated with biotin-LC-hydrazide def: "modification from UniMod Chemical derivative" [UniMod:113#K] synonym: "Oxidized lysine biotinylated with biotin-LC-hydrazide" RELATED UniMod-description [] synonym: "OxLysBiotin" RELATED UniMod-interim [] xref: DiffAvg: "352.45" xref: DiffFormula: "C 16 H 24 N 4 O 3 S 1" xref: DiffMono: "352.156912" xref: Formula: "C 22 H 36 N 6 O 4 S 1" xref: MassAvg: "480.63" xref: MassMono: "480.251875" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00486 name: oxidized proline biotinylated with biotin-LC-hydrazide, reduced def: "modification from UniMod Chemical derivative" [UniMod:114#C] synonym: "Oxidized proline biotinylated with biotin-LC-hydrazide, reduced" RELATED UniMod-description [] synonym: "OxProBiotinRed" RELATED UniMod-interim [] xref: DiffAvg: "371.50" xref: DiffFormula: "C 16 H 29 N 5 O 3 S 1" xref: DiffMono: "371.199111" xref: Formula: "C 21 H 36 N 6 O 4 S 1" xref: MassAvg: "468.62" xref: MassMono: "468.251875" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:00487 name: oxidized proline biotinylated with biotin-LC-hydrazide def: "modification from UniMod Chemical derivative" [UniMod:115#C] synonym: "Oxidized Proline biotinylated with biotin-LC-hydrazide" RELATED UniMod-description [] synonym: "OxProBiotin" RELATED UniMod-interim [] xref: DiffAvg: "369.48" xref: DiffFormula: "C 16 H 27 N 5 O 3 S 1" xref: DiffMono: "369.183461" xref: Formula: "C 21 H 34 N 6 O 4 S 1" xref: MassAvg: "466.60" xref: MassMono: "466.236225" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:00488 name: oxidized arginine biotinylated with biotin-LC-hydrazide def: "modification from UniMod Chemical derivative" [UniMod:116#C] synonym: "OxArgBiotin" RELATED UniMod-interim [] synonym: "Oxidized arginine biotinylated with biotin-LC-hydrazide" RELATED UniMod-description [] xref: DiffAvg: "310.41" xref: DiffFormula: "C 15 H 22 N 2 O 3 S 1" xref: DiffMono: "310.135114" xref: Formula: "C 21 H 34 N 6 O 4 S 1" xref: MassAvg: "466.60" xref: MassMono: "466.236225" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00489 name: oxidized arginine biotinylated with biotin-LC-hydrazide, reduced def: "modification from UniMod Chemical derivative" [UniMod:117#C] synonym: "OxArgBiotinRed" RELATED UniMod-interim [] synonym: "Oxidized arginine biotinylated with biotin-LC-hydrazide, reduced" RELATED UniMod-description [] xref: DiffAvg: "312.43" xref: DiffFormula: "C 15 H 24 N 2 O 3 S 1" xref: DiffMono: "312.150764" xref: Formula: "C 21 H 36 N 6 O 4 S 1" xref: MassAvg: "468.62" xref: MassMono: "468.251875" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00490 name: EDT-iodo-PEO-biotin def: "modification from UniMod Chemical derivative" [UniMod:118] synonym: "EDT-iodo-PEO-biotin" RELATED UniMod-description [] synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label [] xref: DiffAvg: "490.70" xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3" xref: DiffMono: "490.174219" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00491 name: thio ether formation - BTP Adduct def: "modification from UniMod Chemical derivative" [PubMed:11861642, UniMod:119#C] synonym: "IBTP" RELATED PSI-MS-label [] synonym: "Thio Ether Formation - BTP Adduct" RELATED UniMod-description [] xref: DiffAvg: "316.38" xref: DiffFormula: "C 22 H 21 P 1" xref: DiffMono: "316.138087" xref: Formula: "C 25 H 26 N 1 O 1 P 1 S 1" xref: MassAvg: "419.52" xref: MassMono: "419.147272" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00492 name: ubiquitination signature dipeptidyl lysine def: "A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of glycylglycine, the two glycine residues left after tryptic digestion of ubiquitin." [OMSSA:52, PubMed:11125103, PubMed:12612601, PubMed:12872131, RESID:AA0125#var, UniMod:121#K] synonym: "GlyGly" RELATED PSI-MS-label [] synonym: "glyglyk" EXACT OMSSA-label [] synonym: "N6-(glycylglycyl)lysine" EXACT PSI-MOD-alternate [] synonym: "N6-glycylglycyl-L-lysine" EXACT PSI-MOD-alternate [] synonym: "ubiquitinylation residue" RELATED UniMod-description [] xref: DiffAvg: "114.10" xref: DiffFormula: "C 4 H 6 N 2 O 2" xref: DiffMono: "114.042927" xref: Formula: "C 10 H 18 N 4 O 3" xref: MassAvg: "242.28" xref: MassMono: "242.137890" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01875 ! N6-acylated L-lysine relationship: derives_from MOD:01148 ! ubiquitinylated lysine [Term] id: MOD:00493 name: formylated residue def: "A protein modification that effectively replaces a hydrogen atom with a formyl group." [DeltaMass:0, PubMed:15799070, UniMod:122] comment: From DeltaMass: Average Mass: 28 subset: PSI-MOD-slim synonym: "FoRes" EXACT PSI-MOD-label [] synonym: "Formyl" RELATED PSI-MS-label [] synonym: "Formylation" RELATED UniMod-description [] synonym: "Formylation (CHO)" EXACT DeltaMass-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 O 1" xref: DiffMono: "27.994915" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue [Term] id: MOD:00494 name: N-iodoacetyl, p-chlorobenzyl-12C6-glucamine def: "modification from UniMod Isotopic label" [PubMed:12185208, UniMod:123#C] synonym: "ICAT-H" RELATED PSI-MS-label [] synonym: "N-iodoacetyl, p-chlorobenzyl-12C6-glucamine" RELATED UniMod-description [] xref: DiffAvg: "345.78" xref: DiffFormula: "C 15 Cl 1 H 20 N 1 O 6 S 0" xref: DiffMono: "345.097915" xref: Formula: "C 18 Cl 1 H 25 N 2 O 7 S 1" xref: MassAvg: "448.91" xref: MassMono: "448.107100" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00495 name: N-iodoacetyl, p-chlorobenzyl-13C6-glucamine def: "modification from UniMod Isotopic label" [PubMed:12185208, UniMod:124#C] synonym: "ICAT-H:13C(6)" RELATED PSI-MS-label [] synonym: "N-iodoacetyl, p-chlorobenzyl-13C6-glucamine" RELATED UniMod-description [] xref: DiffAvg: "351.12" xref: DiffFormula: "(12)C 9 (13)C 6 Cl 1 H 20 N 1 O 6 S 0" xref: DiffMono: "351.118044" xref: Formula: "(12)C 12 (13)C 6 Cl 1 H 25 N 2 O 7 S 1" xref: MassAvg: "454.13" xref: MassMono: "454.127229" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00496 name: reductive amination-D def: "OBSOLETE because UniMod entry 125 is merged with entry 199, remap to id: MOD:00552" [UniMod:125] xref: DiffAvg: "32.06" xref: DiffFormula: "C 2 (2)H 4" xref: DiffMono: "32.056407" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00497 name: 3-sulfanylpropanoyl (N-term and Lys) def: "modification from UniMod [(35)S]dithiobis(succinimidyl propionate) crosslinking" [PubMed:957432, UniMod:126] comment: The name "thioacylation of primary amines" in UniMod was a misdescription [JSG]. synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED UniMod-alternate [] synonym: "3-sulfanylpropanoyl" RELATED UniMod-description [] synonym: "Thioacyl" RELATED PSI-MS-label [] xref: DiffAvg: "88.12" xref: DiffFormula: "C 3 H 4 O 1 S 1" xref: DiffMono: "87.998286" xref: Formula: "C 9 H 16 N 2 O 2 S 1" xref: MassAvg: "216.30" xref: MassMono: "216.093249" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00498 name: fluorinated residue def: "A protein modification that effectively substitutes a hydrogen of a residue with a fluorine atom." [PubMed:18688235] synonym: "Fluoro" RELATED PSI-MS-label [] synonym: "fluorophenylalanine replacement of phenylalanine" RELATED UniMod-description [] synonym: "Fluorophenylalanyl" EXACT DeltaMass-label [] synonym: "FRes" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue [Term] id: MOD:00499 name: 5-iodoacetamidofluorescein def: "modification from UniMod Chemical derivative" [PubMed:3311742, PubMed:3578767, UniMod:128#C] synonym: "5-Iodoacetamidofluorescein (Molecular Probe, Eugene, OR)" RELATED UniMod-description [] synonym: "Fluorescein" RELATED PSI-MS-label [] xref: DiffAvg: "388.35" xref: DiffFormula: "C 22 H 14 N 1 O 6" xref: DiffMono: "388.082112" xref: Formula: "C 25 H 19 N 2 O 7 S 1" xref: MassAvg: "491.49" xref: MassMono: "491.091297" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00500 name: monoiodinated residue def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one iodine atom." [DeltaMass:0, PubMed:15627961, PubMed:2026710, UniMod:129] comment: From DeltaMass: Average Mass: 126 subset: PSI-MOD-slim synonym: "I1Res" EXACT PSI-MOD-label [] synonym: "Iodination" RELATED UniMod-description [] synonym: "Iodination (of Histidine[C4] or Tyrosine[C3])" EXACT DeltaMass-label [] synonym: "Iodo" RELATED PSI-MS-label [] xref: DiffAvg: "125.90" xref: DiffFormula: "H -1 I 1" xref: DiffMono: "125.896648" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00755 ! iodinated residue [Term] id: MOD:00501 name: diiodinated residue def: "A protein modification that effectively substitutes two hydrogen atoms of a residue with two iodine atoms." [UniMod:130] comment: From DeltaMass: Average Mass: 252 subset: PSI-MOD-slim synonym: "di-Iodination" RELATED UniMod-description [] synonym: "Diiodo" RELATED PSI-MS-label [] synonym: "I2Res" EXACT PSI-MOD-label [] xref: DiffAvg: "251.79" xref: DiffFormula: "H -2 I 2" xref: DiffMono: "251.793295" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00755 ! iodinated residue [Term] id: MOD:00502 name: triiodinated residue def: "A protein modification that effectively substitutes three hydrogen atoms of a residue with three iodine atoms." [OMSSA:116, PubMed:15627961, PubMed:2026710, UniMod:131] comment: From UniMod. In PubMed:2026710, mono- and diiodination of tyrosine are discussed, but triiodination of tyrosine is not mentioned. In PubMed:15627961, triiodothyronine (see MOD:00186) is discussed, but triiodotyrosine is not mentioned. This modification probably does not exist, and may be a confusion of "tyrosine" for "thyronine", a common error [JSG]. subset: PSI-MOD-slim synonym: "I3Res" EXACT PSI-MOD-label [] synonym: "tri-Iodination" RELATED UniMod-description [] synonym: "triiodinationy" EXACT OMSSA-label [] synonym: "Triiodo" RELATED PSI-MS-label [] xref: DiffAvg: "377.69" xref: DiffFormula: "H -3 I 3" xref: DiffMono: "377.689943" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00755 ! iodinated residue [Term] id: MOD:00503 name: N-(cis-delta 5)-tetradecaenoylglycine def: "A protein modification that effectively converts a glycine residue to N-(cis-delta 5)-tetradecaenoylglycine." [OMSSA:78, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059#var, UniMod:134#G] synonym: "(cis-delta 5)-tetradecaenoyl" RELATED UniMod-description [] synonym: "Myristoleyl" RELATED PSI-MS-label [] synonym: "myristoleylation (one double bond)" EXACT DeltaMass-label [] synonym: "N-(C14:1 aliphatic acyl)glycine" EXACT PSI-MOD-alternate [] synonym: "ntermpepmyristoyeylationg" EXACT OMSSA-label [] xref: DiffAvg: "208.35" xref: DiffFormula: "C 14 H 24 N 0 O 1" xref: DiffMono: "208.182715" xref: Formula: "C 16 H 27 N 1 O 2" xref: MassAvg: "265.40" xref: MassMono: "265.204179" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:00504 name: N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine def: "A protein modification that effectively converts a glycine residue to N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine." [OMSSA:79, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059#var, UniMod:135#G] synonym: "(cis,cis-delta 5, delta 8)-tetradecadienoyl" RELATED UniMod-description [] synonym: "Myristoyl+Delta:H(-4)" RELATED PSI-MS-label [] synonym: "myristoylation-4H (two double bonds)" EXACT DeltaMass-label [] synonym: "N-(C14:2 aliphatic acyl)glycine" EXACT PSI-MOD-alternate [] synonym: "ntermpepmyristoyl4hg" EXACT OMSSA-label [] xref: DiffAvg: "206.33" xref: DiffFormula: "C 14 H 22 O 1" xref: DiffMono: "206.167065" xref: Formula: "C 16 H 25 N 1 O 2" xref: MassAvg: "263.38" xref: MassMono: "263.188529" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:00505 name: benzoyl labeling reagent light form (N-term and K) def: "modification from UniMod Isotopic label" [DeltaMass:0, PubMed:15456300, UniMod:136] comment: From DeltaMass: Average Mass: 104 synonym: "Benzoyl" RELATED PSI-MS-label [] synonym: "Benzoyl (Bz)" EXACT DeltaMass-label [] synonym: "labeling reagent light form (N-term & K)" RELATED UniMod-description [] xref: DiffAvg: "104.11" xref: DiffFormula: "C 7 H 4 O 1" xref: DiffMono: "104.026215" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00506 name: N-linked glycan core def: "modification from UniMod N-linked glycosylation, Hex(5) HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:137#N] synonym: "Hex(5)HexNAc(2)" RELATED PSI-MS-label [] synonym: "N-linked glycan core" RELATED UniMod-description [] xref: DiffAvg: "1217.09" xref: DiffFormula: "C 46 H 76 N 2 O 35" xref: DiffMono: "1216.422862" xref: Formula: "C 50 H 82 N 4 O 37" xref: MassAvg: "1331.20" xref: MassMono: "1330.465790" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00507 name: 5-dimethylaminonaphthalene-1-sulfonyl def: "OBSOLETE because redundant, replaced by MOD:01653. Remap to MOD:01653." [DeltaMass:0, UniMod:139] comment: From DeltaMass: Average Mass: 233 synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] synonym: "Dansyl" RELATED PSI-MS-label [] synonym: "Dansyl (Dns)" EXACT DeltaMass-label [] xref: DiffAvg: "233.29" xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" xref: DiffMono: "233.051050" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00508 name: ISD a-series (C-Term) def: "modification from UniMod Other" [PubMed:14588022, UniMod:140] comment: Virtual Modification for MS/MS of a-type ions, by decarboxylation of C-terminus as reaction inside the mass spectrometer. synonym: "a-type-ion" RELATED PSI-MS-label [] synonym: "ISD a-series (C-Term)" RELATED UniMod-description [] xref: DiffAvg: "-29.02" xref: DiffFormula: "C -1 H -1 O -1" xref: DiffMono: "-29.002740" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:00003 ! UniMod [Term] id: MOD:00509 name: amidination of lysines or N-terminal amines with methyl acetimidate def: "modification from UniMod Chemical derivative" [PubMed:12643539, PubMed:6273432, UniMod:141] synonym: "amidination of lysines or N-terminal amines with methyl acetimidate" RELATED UniMod-description [] synonym: "Amidine" RELATED PSI-MS-label [] xref: DiffAvg: "41.05" xref: DiffFormula: "C 2 H 3 N 1" xref: DiffMono: "41.026549" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00510 name: HexNAc1dHex1 def: "modification from UniMod N-linked glycosylation, dHex HexNAc" [OMSSA:183, PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:142] synonym: "dHexHexNAcN" EXACT OMSSA-label [] synonym: "HexNAc(1)dHex(1)" RELATED PSI-MS-label [] synonym: "HexNAc1dHex1" RELATED UniMod-description [] xref: DiffAvg: "349.34" xref: DiffFormula: "C 14 H 23 N 1 O 9" xref: DiffMono: "349.137281" xref: Formula: "C 18 H 29 N 3 O 11" xref: MassAvg: "463.44" xref: MassMono: "463.180209" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00511 name: HexNAc2 def: "modification from UniMod N-linked glycosylation, HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:143] synonym: "HexNAc(2)" RELATED PSI-MS-label [] synonym: "HexNAc2" RELATED UniMod-description [] xref: DiffAvg: "406.39" xref: DiffFormula: "C 16 H 26 N 2 O 10" xref: DiffMono: "406.158745" xref: Formula: "C 20 H 32 N 4 O 12" xref: MassAvg: "520.49" xref: MassMono: "520.201672" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00512 name: Hex3 def: "modification from UniMod N-linked glycosylation, Hex3" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:144] synonym: "Hex(3)" RELATED PSI-MS-label [] synonym: "Hex3" RELATED UniMod-description [] xref: DiffAvg: "486.42" xref: DiffFormula: "C 18 H 30 O 15" xref: DiffMono: "486.158470" xref: Formula: "C 22 H 36 N 2 O 17" xref: MassAvg: "600.53" xref: MassMono: "600.201398" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00513 name: HexNAc1dHex2 def: "modification from UniMod N-linked glycosylation, dHex(2) HexNAc" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:145] synonym: "HexNAc(1)dHex(2)" RELATED PSI-MS-label [] synonym: "HexNAc1dHex2" RELATED UniMod-description [] xref: DiffAvg: "495.48" xref: DiffFormula: "C 20 H 33 N 1 O 13" xref: DiffMono: "495.195190" xref: Formula: "C 24 H 39 N 3 O 15" xref: MassAvg: "609.58" xref: MassMono: "609.238118" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00514 name: Hex1HexNAc1dHex1 def: "modification from UniMod N-linked glycosylation, dHex Hex HexNAc" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:146] synonym: "Hex(1)HexNAc(1)dHex(1)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1dHex1" RELATED UniMod-description [] xref: DiffAvg: "511.48" xref: DiffFormula: "C 20 H 33 N 1 O 14" xref: DiffMono: "511.190105" xref: Formula: "C 24 H 39 N 3 O 16" xref: MassAvg: "625.58" xref: MassMono: "625.233032" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00515 name: HexNAc2dHex1 def: "modification from UniMod N-linked glycosylation, dHex HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, UniMod:147] synonym: "HexNAc(2)dHex(1)" RELATED PSI-MS-label [] synonym: "HexNAc2dHex1" RELATED UniMod-description [] xref: DiffAvg: "552.53" xref: DiffFormula: "C 22 H 36 N 2 O 14" xref: DiffMono: "552.216654" xref: Formula: "C 26 H 42 N 4 O 16" xref: MassAvg: "666.63" xref: MassMono: "666.259581" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00516 name: Hex1HexNAc2 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:148] synonym: "Hex(1)HexNAc(2)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc2" RELATED UniMod-description [] xref: DiffAvg: "568.53" xref: DiffFormula: "C 22 H 36 N 2 O 15" xref: DiffMono: "568.211568" xref: Formula: "C 26 H 42 N 4 O 17" xref: MassAvg: "682.63" xref: MassMono: "682.254496" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00517 name: Hex1HexNAc1NeuAc1 glycosylated residue def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [DeltaMass:0, UniMod:149] comment: From DeltaMass: Average Mass: 657 synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1NeuAc1" RELATED UniMod-description [] synonym: "NeuAc-Hex-HexNAc" EXACT DeltaMass-label [] xref: DiffAvg: "657.60" xref: DiffFormula: "C 25 H 41 N 2 O 18" xref: DiffMono: "657.235437" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00518 name: HexNAc2dHex2 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:150] synonym: "HexNAc(2)dHex(2)" RELATED PSI-MS-label [] synonym: "HexNAc2dHex2" RELATED UniMod-description [] xref: DiffAvg: "698.67" xref: DiffFormula: "C 28 H 46 N 2 O 18" xref: DiffMono: "698.274563" xref: Formula: "C 32 H 52 N 4 O 20" xref: MassAvg: "812.78" xref: MassMono: "812.317490" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00519 name: Hex1HexNAc2Pent1 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:151] synonym: "Hex(1)HexNAc(2)Pent(1)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc2Pent1" RELATED UniMod-description [] xref: DiffAvg: "700.64" xref: DiffFormula: "C 27 H 44 N 2 O 19" xref: DiffMono: "700.253827" xref: Formula: "C 31 H 50 N 4 O 21" xref: MassAvg: "814.75" xref: MassMono: "814.296755" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00520 name: Hex1HexNAc2dHex1 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:152] synonym: "Hex(1)HexNAc(2)dHex(1)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc2dHex1" RELATED UniMod-description [] xref: DiffAvg: "714.67" xref: DiffFormula: "C 28 H 46 N 2 O 19" xref: DiffMono: "714.269477" xref: Formula: "C 32 H 52 N 4 O 21" xref: MassAvg: "828.77" xref: MassMono: "828.312405" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00521 name: Hex2HexNAc2 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:153] synonym: "Hex(2)HexNAc(2)" RELATED PSI-MS-label [] synonym: "Hex2HexNAc2" RELATED UniMod-description [] xref: DiffAvg: "730.67" xref: DiffFormula: "C 28 H 46 N 2 O 20" xref: DiffMono: "730.264392" xref: Formula: "C 32 H 52 N 4 O 22" xref: MassAvg: "844.77" xref: MassMono: "844.307319" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00522 name: Hex3HexNAc1Pent1 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:154] synonym: "Hex(3)HexNAc(1)Pent(1)" RELATED PSI-MS-label [] synonym: "Hex3HexNAc1Pent1" RELATED UniMod-description [] xref: DiffAvg: "821.73" xref: DiffFormula: "C 31 H 51 N 1 O 24" xref: DiffMono: "821.280102" xref: Formula: "C 35 H 57 N 3 O 26" xref: MassAvg: "935.84" xref: MassMono: "935.323029" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00523 name: Hex1HexNAc2dHex1Pent1 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:155] synonym: "Hex(1)HexNAc(2)dHex(1)Pent(1)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc2dHex1Pent1" RELATED UniMod-description [] xref: DiffAvg: "846.79" xref: DiffFormula: "C 33 H 54 N 2 O 23" xref: DiffMono: "846.311736" xref: Formula: "C 35 H 57 N 3 O 26" xref: MassAvg: "935.84" xref: MassMono: "935.323029" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00524 name: Hex1HexNAc2dHex2 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:156] synonym: "Hex(1)HexNAc(2)dHex(2)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc2dHex2" RELATED UniMod-description [] xref: DiffAvg: "860.81" xref: DiffFormula: "C 34 H 56 N 2 O 23" xref: DiffMono: "860.327386" xref: Formula: "C 38 H 62 N 4 O 25" xref: MassAvg: "974.92" xref: MassMono: "974.370313" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00525 name: Hex2HexNAc2Pent1 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:157] synonym: "Hex(2)HexNAc(2)Pent(1)" RELATED PSI-MS-label [] synonym: "Hex2HexNAc2Pent1" RELATED UniMod-description [] xref: DiffAvg: "862.79" xref: DiffFormula: "C 33 H 54 N 2 O 24" xref: DiffMono: "862.306651" xref: Formula: "C 37 H 60 N 4 O 26" xref: MassAvg: "976.89" xref: MassMono: "976.349578" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00526 name: Hex2HexNAc2dHex1 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:158] synonym: "Hex(2)HexNAc(2)dHex(1)" RELATED PSI-MS-label [] synonym: "Hex2HexNAc2dHex1" RELATED UniMod-description [] xref: DiffAvg: "876.81" xref: DiffFormula: "C 34 H 56 N 2 O 24" xref: DiffMono: "876.322301" xref: Formula: "C 38 H 62 N 4 O 26" xref: MassAvg: "990.92" xref: MassMono: "990.365228" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00527 name: Hex3HexNAc2 def: "modification from UniMod N-linked glycosylation" [DeltaMass:0, RESID:AA0151#var, UniMod:159] comment: From DeltaMass: Average Mass: 893 synonym: "(Hex)3-HexNAc-HexNAc" EXACT DeltaMass-label [] synonym: "Hex(3)HexNAc(2)" RELATED PSI-MS-label [] synonym: "Hex3HexNAc2" RELATED UniMod-description [] xref: DiffAvg: "892.81" xref: DiffFormula: "C 34 H 56 N 2 O 25" xref: DiffMono: "892.317215" xref: Formula: "C 38 H 62 N 4 O 27" xref: MassAvg: "1006.92" xref: MassMono: "1006.360143" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00528 name: Hex1HexNAc1NeuAc2 glycosylated residue def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [UniMod:160] synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1NeuAc2" RELATED UniMod-description [] xref: DiffAvg: "947.85" xref: DiffFormula: "C 36 H 57 N 3 O 26" xref: DiffMono: "947.323029" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00529 name: Hex3HexNAc2P1 def: "modification from UniMod N-linked glycosylation" [RESID:AA0151#var, UniMod:161] synonym: "Hex(3)HexNAc(2)P(1)" RELATED PSI-MS-label [] synonym: "Hex3HexNAc2P1" RELATED UniMod-description [] xref: DiffAvg: "972.79" xref: DiffFormula: "C 34 H 57 N 2 O 28 P 1" xref: DiffMono: "972.283546" xref: Formula: "C 38 H 63 N 4 O 30 P 1" xref: MassAvg: "1086.89" xref: MassMono: "1086.326473" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00530 name: L-selenomethionine def: "A protein modification that effectively converts an L-methionine residue to L-selenomethionine." [OMSSA:113, PubMed:12148805, UniMod:162#M] synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label [] synonym: "Se(S)Met" EXACT PSI-MOD-label [] synonym: "Selenium replaces sulphur" RELATED UniMod-description [] synonym: "semetm" EXACT OMSSA-label [] xref: DiffAvg: "46.91" xref: DiffFormula: "C 0 H 0 N 0 S -1 Se 1" xref: DiffMono: "47.944450" xref: Formula: "C 5 H 9 N 1 O 1 Se 1" xref: MassAvg: "178.10" xref: MassMono: "178.984935" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00007 ! selenium substitution for sulfur is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00531 name: (18)O labeled deglycosylated asparagine def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O as the result of having been deglycosylated in (18)O water." [PubMed:14435542, UniMod:170] subset: PSI-MOD-slim synonym: "Delta:H(1)O(-1)18O(1)" RELATED PSI-MS-label [] synonym: "glycosylated asparagine 18O labeling" RELATED UniMod-description [] xref: DiffAvg: "2.99" xref: DiffFormula: "H -1 N -1 (18)O 1" xref: DiffMono: "2.988262" xref: Formula: "C 4 H 5 N 1 (16)O 2 (18)O 1" xref: MassAvg: "117.03" xref: MassMono: "117.031189" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01293 ! 1x(18)O labeled deamidated L-asparagine [Term] id: MOD:00532 name: Shimadzu 13CNBS def: "modification from UniMod Chemical derivative" [PubMed:12845591, UniMod:171] synonym: "NBS:13C(6)" RELATED UniMod-interim [] synonym: "Shimadzu NBS-13C" RELATED UniMod-description [] xref: DiffAvg: "159.01" xref: DiffFormula: "(13)C 6 H 3 N 1 O 2 S 1" xref: DiffMono: "159.008578" xref: Formula: "(12)C 11 (13)C 6 H 13 N 3 O 3 S 1" xref: MassAvg: "345.09" xref: MassMono: "345.087891" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00533 name: Shimadzu 12CNBS def: "modification from UniMod Chemical derivative" [PubMed:12845591, UniMod:172] synonym: "NBS" RELATED UniMod-interim [] synonym: "Shimadzu NBS-12C" RELATED UniMod-description [] xref: DiffAvg: "152.99" xref: DiffFormula: "(12)C 6 H 3 N 1 O 2 S 1" xref: DiffMono: "152.988449" xref: Formula: "(12)C 17 H 13 N 3 O 3 S 1" xref: MassAvg: "339.07" xref: MassMono: "339.067762" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00534 name: Michael addition of BHT quinone methide to cysteine and lysine def: "modification from UniMod Post-translational" [PubMed:9448752, UniMod:176] comment: Butylated Hydroxytoluene adduct. synonym: "BHT" RELATED PSI-MS-label [] synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED UniMod-description [] xref: DiffAvg: "218.34" xref: DiffFormula: "C 15 H 22 O 1" xref: DiffMono: "218.167065" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00535 name: phosphorylation to amine thiol def: "modification from UniMod Chemical derivative" [PubMed:12216740, UniMod:178] comment: DAET = 2-(dimethylamino)ethanethiol. The phosphorylation to amine is the beta elimination of phosphate and Michael addition of 2-(dimethylamino)ethanethiol to the site. synonym: "DAET" RELATED PSI-MS-label [] synonym: "phosphorylation to amine thiol" RELATED UniMod-description [] xref: DiffAvg: "87.18" xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1" xref: DiffMono: "87.050656" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00536 name: L-serine to L-alanine replacement def: "OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? a protein modification that replaces an L-serine residue with an L-alanine residue" [UniMod:179] synonym: "Ser_Ala" EXACT PSI-MOD-label [] xref: DiffAvg: "-16.00" xref: DiffFormula: "O -1" xref: DiffMono: "-15.994915" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00537 name: L-alanine residue (Thr) def: "A protein modification that effectively converts an L-threonine residue to L-alanine." [UniMod:659] comment: This could represent either an engineered replacement or a chemical modification. synonym: "Thr(Ala)" EXACT PSI-MOD-label [] synonym: "Thr->Ala" RELATED UniMod-interim [] synonym: "Thr->Ala substitution" RELATED UniMod-description [] xref: DiffAvg: "-30.03" xref: DiffFormula: "C -1 H -2 O -1" xref: DiffMono: "-30.010565" xref: Formula: "C 3 H 5 N 1 O 1" xref: MassAvg: "71.08" xref: MassMono: "71.037114" xref: Origin: "T" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00010 ! L-alanine residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00538 name: protein modification categorized by isobaric sets def: "Modified amino acid residues groups into isobaric sets at particular mass resolution cut-offs." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00000 ! protein modification [Term] id: MOD:00539 name: threonine reduced to aminobutynate def: "OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? modification from UniMod O-linked glycosylation" [UniMod:182] xref: DiffAvg: "-17.01" xref: DiffFormula: "H -1 O -1" xref: DiffMono: "-17.002740" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00540 name: 9x(13)C labeled residue def: "A protein modification that effectively converts a residue containing common isotopes to a 9x(13)C labeled residue." [PubMed:12716131, UniMod:184] synonym: "13C(9) Silac label" RELATED UniMod-description [] synonym: "Label:13C(9)" RELATED PSI-MS-label [] xref: DiffAvg: "9.03" xref: DiffFormula: "(12)C -9 (13)C 9" xref: DiffMono: "9.030194" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00842 ! (13)C labeled residue [Term] id: MOD:00541 name: 9x(13)C labeled L-phosphotyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-phosphotyrosine." [PubMed:12716131, UniMod:185] synonym: "C13 label (Phosphotyrosine)" RELATED UniMod-description [] synonym: "Label:13C(9)+Phospho" RELATED PSI-MS-label [] xref: DiffAvg: "89.00" xref: DiffFormula: "(12)C -9 (13)C 9 H 1 O 3 P 1" xref: DiffMono: "88.996524" xref: Formula: "(13)C 9 H 10 N 1 O 5 P 1" xref: MassAvg: "252.06" xref: MassMono: "252.059853" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00540 ! 9x(13)C labeled residue is_a: MOD:00919 ! modified L-tyrosine residue relationship: derives_from MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: MOD:00542 name: hydroxyphenylglyoxal arginine def: "modification from UniMod Chemical derivative" [PubMed:11698400, PubMed:11914093, UniMod:186] synonym: "HPG" RELATED PSI-MS-label [] synonym: "Hydroxyphenylglyoxal arginine" RELATED UniMod-description [] xref: DiffAvg: "132.12" xref: DiffFormula: "C 8 H 4 O 2" xref: DiffMono: "132.021129" xref: Formula: "C 14 H 16 N 4 O 3" xref: MassAvg: "288.31" xref: MassMono: "288.122240" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00543 name: bis(hydroxyphenylglyoxal) arginine def: "modification from UniMod Chemical derivative" [PubMed:11698400, UniMod:187] comment: OH-PGO and PGO react with arginine at a stoichiometry of 2:1 [UniMod]. synonym: "2HPG" RELATED PSI-MS-label [] synonym: "bis(hydroxphenylglyoxal) arginine" RELATED UniMod-description [] xref: DiffAvg: "282.25" xref: DiffFormula: "C 16 H 10 O 5" xref: DiffMono: "282.052823" xref: Formula: "C 22 H 22 N 4 O 6" xref: MassAvg: "438.44" xref: MassMono: "438.153934" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00544 name: 6x(13)C labeled residue def: "A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C labeled residue." [PubMed:12716131, UniMod:188] subset: PSI-MOD-slim synonym: "13C(6) Silac label" RELATED UniMod-description [] synonym: "Label:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "6.02" xref: DiffFormula: "(12)C -6 (13)C 6" xref: DiffMono: "6.020129" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00842 ! (13)C labeled residue [Term] id: MOD:00545 name: deuterated dimethyl labeling (D) def: "OBSOLETE because redundant with MOD:00927. Remap to MOD:00927." [PubMed:14670044] xref: DiffAvg: "34.07" xref: DiffFormula: "C 2 (1)H -2 (2)H 6" xref: DiffMono: "34.068961" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_obsolete: true [Term] id: MOD:00546 name: (18)O label at both C-terminal oxygens def: "A protein modification that effectively substitutes two (18)O atom for the two (16)O atoms of an alpha-carboxyl (1-carboxyl) group." [OMSSA:88, PubMed:11467524, UniMod:193] subset: PSI-MOD-slim synonym: "ctermpepdio18" EXACT OMSSA-label [] synonym: "Label:18O(2)" RELATED PSI-MS-label [] synonym: "O18 label at both C-terminal oxygens" RELATED UniMod-description [] xref: DiffAvg: "4.01" xref: DiffFormula: "(16)O -2 (18)O 2" xref: DiffMono: "4.008493" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:00847 ! (18)O disubstituted residue [Term] id: MOD:00547 name: 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate def: "modification from UniMod Chemical derivative" [PubMed:14997490, UniMod:194] synonym: "6-aminoquinolyl-N-hydroxysuccinimidyl carbamate" RELATED UniMod-description [] synonym: "AccQTag" RELATED PSI-MS-label [] xref: DiffAvg: "170.17" xref: DiffFormula: "C 10 H 6 N 2 O 1" xref: DiffMono: "170.048013" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00548 name: APTA-d0 def: "modification from UniMod Chemical derivative" [PubMed:15283597, UniMod:195] comment: Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride [JSG]. synonym: "APTA-d0" RELATED UniMod-description [] synonym: "QAT" RELATED PSI-MS-label [] xref: DiffAvg: "171.26" xref: DiffFormula: "C 9 H 19 N 2 O 1" xref: DiffMono: "171.149738" xref: Formula: "C 12 H 24 N 3 O 2 S 1" xref: MassAvg: "274.40" xref: MassMono: "274.158923" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00549 name: APTA d3 def: "modification from UniMod Isotopic label" [PubMed:15283597, UniMod:196] comment: Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride (difference formula correct) [JSG]. synonym: "(3-acrylamidopropyl)trimethylammonium" RELATED UniMod-description [] synonym: "APTA d3" RELATED UniMod-description [] synonym: "QAT:2H(3)" RELATED PSI-MS-label [] xref: DiffAvg: "174.17" xref: DiffFormula: "C 9 (1)H 16 (2)H 3 N 2 O 1" xref: DiffMono: "174.168568" xref: Formula: "C 12 (1)H 21 (2)H 3 N 3 O 2 S 1" xref: MassAvg: "277.18" xref: MassMono: "277.177753" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01431 ! (2)H deuterium tagged reagent [Term] id: MOD:00550 name: EAPTA d0 def: "modification from UniMod Chemical derivative" [UniMod:197] synonym: "EAPTA d0" RELATED UniMod-description [] synonym: "EQAT" RELATED PSI-MS-label [] xref: DiffAvg: "184.28" xref: DiffFormula: "C 10 H 20 N 2 O 1" xref: DiffMono: "184.157563" xref: Formula: "C 13 H 25 N 3 O 2 S 1" xref: MassAvg: "287.42" xref: MassMono: "287.166748" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00551 name: EAPTA d5 def: "modification from UniMod Isotopic label" [UniMod:198] synonym: "EAPTA d5" RELATED UniMod-description [] synonym: "EQAT:2H(5)" RELATED PSI-MS-label [] xref: DiffAvg: "189.19" xref: DiffFormula: "C 10 (1)H 15 (2)H 5 N 2 O 1" xref: DiffMono: "189.188947" xref: Formula: "C 13 (1)H 20 (2)H 5 N 3 O 2 S 1" xref: MassAvg: "292.20" xref: MassMono: "292.198132" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01431 ! (2)H deuterium tagged reagent [Term] id: MOD:00552 name: 4x(2)H labeled dimethylated residue def: "A protein modification that effectively converts a residue containing common isotopes to a 4x(2)H labeled dimethylated residue." [PubMed:14670044, UniMod:199] comment: Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. subset: PSI-MOD-slim synonym: "DiMethyl-CHD2" RELATED UniMod-description [] synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label [] xref: DiffAvg: "32.06" xref: DiffFormula: "C 2 (2)H 4" xref: DiffMono: "32.056407" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00839 ! (2)H deuterium labeled residue [Term] id: MOD:00553 name: 1,2-ethanedithiol modified residue def: "A protein modification that effectively substitutes a (2-sulfanylethyl)sulfanyl (or thioethylthiol) group for a hydroxy group." [DeltaMass:0, PubMed:11507762, UniMod:200] comment: From DeltaMass: Average Mass: 93; supposed to be derivatization of serine and threonine. synonym: "1,2-ethanedithiol (EDT)" EXACT DeltaMass-label [] synonym: "EDT" RELATED UniMod-description [] synonym: "Ethanedithiol" RELATED PSI-MS-label [] xref: DiffAvg: "76.18" xref: DiffFormula: "C 2 H 4 O -1 S 2" xref: DiffMono: "75.980528" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00554 name: APTA-d0 with no neutral loss def: "OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative" [UniMod:202] xref: DiffAvg: "170.26" xref: DiffFormula: "C 9 H 18 N 2 O 1" xref: DiffMono: "170.141913" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00555 name: APTA-d0 with quaternary amine loss def: "OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative" [UniMod:203] xref: DiffAvg: "170.26" xref: DiffFormula: "C 9 H 18 N 2 O 1" xref: DiffMono: "170.141913" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00556 name: acrolein addition +94 def: "modification from UniMod Other" [UniMod:205] synonym: "Acrolein addition +94" RELATED UniMod-description [] synonym: "Delta:H(6)C(6)O(1)" RELATED PSI-MS-label [] xref: DiffAvg: "94.11" xref: DiffFormula: "C 6 H 6 O 1" xref: DiffMono: "94.041865" xref: Formula: "C 12 H 18 N 2 O 2" xref: MassAvg: "222.29" xref: MassMono: "222.136828" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00557 name: acrolein addition +56 def: "modification from UniMod Other" [PubMed:10825247, PubMed:15541752, UniMod:206] synonym: "Acrolein addition +56" RELATED UniMod-description [] synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label [] xref: DiffAvg: "56.06" xref: DiffFormula: "C 3 H 4 O 1" xref: DiffMono: "56.026215" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00558 name: acrolein addition +38 def: "modification from UniMod Other" [UniMod:207] synonym: "Acrolein addition +38" RELATED UniMod-description [] synonym: "Delta:H(2)C(3)" RELATED PSI-MS-label [] xref: DiffAvg: "38.05" xref: DiffFormula: "C 3 H 2" xref: DiffMono: "38.015650" xref: Formula: "C 9 H 14 N 2 O 1" xref: MassAvg: "166.22" xref: MassMono: "166.110613" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00559 name: acrolein addition +76 def: "modification from UniMod Other" [UniMod:208] synonym: "Acrolein addition +76" RELATED UniMod-description [] synonym: "Delta:H(4)C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "76.10" xref: DiffFormula: "C 6 H 4" xref: DiffMono: "76.031300" xref: Formula: "C 12 H 16 N 2 O 1" xref: MassAvg: "204.27" xref: MassMono: "204.126263" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00560 name: acrolein addition +112 def: "modification from UniMod Other" [UniMod:209] synonym: "Acrolein addition +112" RELATED UniMod-description [] synonym: "Delta:H(8)C(6)O(2)" RELATED PSI-MS-label [] xref: DiffAvg: "112.13" xref: DiffFormula: "C 6 H 8 O 2" xref: DiffMono: "112.052429" xref: Formula: "C 12 H 20 N 2 O 3" xref: MassAvg: "240.30" xref: MassMono: "240.147393" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00561 name: N-ethyl iodoacetamide-d0 def: "modification from UniMod Isotopic label" [PubMed:12766232, UniMod:211] synonym: "N-ethyl iodoacetamide-d0" RELATED UniMod-description [] synonym: "NEIAA" RELATED PSI-MS-label [] xref: DiffAvg: "85.11" xref: DiffFormula: "C 4 H 7 N 1 O 1" xref: DiffMono: "85.052764" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00562 name: N-ethyl iodoacetamide-d5 def: "modification from UniMod Isotopic label" [PubMed:12766232, UniMod:212] synonym: "N-ethyl iodoacetamide-d5" RELATED UniMod-description [] synonym: "NEIAA:2H(5)" RELATED PSI-MS-label [] xref: DiffAvg: "90.08" xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1" xref: DiffMono: "90.084148" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01431 ! (2)H deuterium tagged reagent [Term] id: MOD:00563 name: N-acetylaminogalactosylated residue def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminogalactose group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "GalNAcRes" EXACT PSI-MOD-label [] synonym: "HexNAc" RELATED PSI-MS-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00734 ! N-acetylaminogalactosylated is_a: MOD:01673 ! N-acetylaminohexosylated residue [Term] id: MOD:00564 name: Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry def: "Modification from UniMod Isotopic label. The UniMod term was extracted when it had not been approved. OBSOLETE because redundant to MOD:01505. Remap to MOD:01505, or one of the child terms MOD:01493 or MOD:01497." [UniMod:214, URL:http\://docs.appliedbiosystems.com/pebiodocs/04351918.pdf] synonym: "iTRAQ4plex" RELATED UniMod-interim [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 O 1" xref: DiffMono: "144.102062" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00565 name: deglycosylated asparagine def: "modification from UniMod N-linked glycosylation" [UniMod:7#N] comment: Conversion of glycosylated asparagine residues upon deglycosylation with PGNase F in H2O. CAUTION - the difference formula appears to be based on a partial structure [JSG]. synonym: "Deamidated" RELATED UniMod-interim [] synonym: "Deamidation" RELATED UniMod-description [] xref: DiffAvg: "0.98" xref: DiffFormula: "H -1 N -1 O 1" xref: DiffMono: "0.984016" xref: Formula: "C 4 H 5 N 1 O 3" xref: MassAvg: "115.09" xref: MassMono: "115.026943" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00566 name: label cysteine with IGBP reagent def: "modification from UniMod Chemical derivative" [UniMod:243] comment: "IDBEST tag for quantitation, http://www.targetdiscovery.com/index.php?topic=prod.idbe" synonym: "IGBP" RELATED PSI-MS-label [] synonym: "Light IDBEST tag for quantitation" RELATED UniMod-description [] xref: DiffAvg: "297.15" xref: DiffFormula: "Br 1 C 12 H 13 N 2 O 2" xref: DiffMono: "296.016040" xref: Formula: "Br 1 C 15 H 18 N 3 O 3 S 1" xref: MassAvg: "400.29" xref: MassMono: "399.025225" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00567 name: histidine oxidation to asparagine def: "OBSOLETE because UniMod entry 244 is redundant with UniMod 348. Remap to MOD:00775." [ChEBI:29956, PubMed:15736973, PubMed:5681232, PubMed:6692818, PubMed:9789001, RESID:AA0003, UniMod:244] xref: DiffAvg: "-23.04" xref: DiffFormula: "C -2 H -1 N -1 O 1" xref: DiffMono: "-23.015984" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00568 name: histidine oxidation to aspartic acid def: "OBSOLETE because UniMod entry 245 is redundant with UniMod 349. Remap to MOD:00776" [PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, UniMod:245] xref: DiffAvg: "-22.05" xref: DiffFormula: "C -2 H -2 N -2 O 2" xref: DiffMono: "-22.031969" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00569 name: residues isobaric at a resolution below 0.000001 Da def: "Natural or modified residues that are isobaric at a resolution below 0.000001 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da [Term] id: MOD:00570 name: residues isobaric at 71.037114 Da def: "Natural or modified residues with a mass of 71.037114 Da." [PubMed:18688235] is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da is_a: MOD:00769 ! residues isobaric at 71.0-71.1 Da [Term] id: MOD:00571 name: 2-pyrrolidone-5-carboxylic acid (Pro) def: "A modification that effectively oxygenates C5 of an L-proline residue to form a 2-pyrrolidone-5-carboxylic acid, pyroglutamic acid." [OMSSA:111, PubMed:9252331, UniMod:359] comment: The review article PubMed:9252331 does not provide an original citation for this modification [JSG]. synonym: "Pro->pyro-Glu" RELATED PSI-MS-label [] synonym: "PyrGlu(Pro)" EXACT PSI-MOD-label [] synonym: "Pyroglutamic" RELATED UniMod-interim [] synonym: "pyroglutamicp" EXACT OMSSA-label [] xref: DiffAvg: "13.98" xref: DiffFormula: "H -2 O 1" xref: DiffMono: "13.979265" xref: Formula: "C 5 H 6 N 1 O 2" xref: MassAvg: "112.11" xref: MassMono: "112.039853" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid [Term] id: MOD:00572 name: oxidized arginine biotinylated with biotin hydrazide def: "modification from UniMod Chemical derivative" [PubMed:15174056, PubMed:15828771, UniMod:343] synonym: "Argbiotinhydrazide" RELATED UniMod-interim [] synonym: "oxidized Arginine biotinylated with biotin hydrazide" RELATED UniMod-description [] xref: DiffAvg: "199.27" xref: DiffFormula: "C 9 H 13 N 1 O 2 S 1" xref: DiffMono: "199.066700" xref: Formula: "C 15 H 25 N 5 O 3 S 1" xref: MassAvg: "355.46" xref: MassMono: "355.167811" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00573 name: oxidized lysine biotinylated with biotin hydrazide def: "modification from UniMod Chemical derivative" [PubMed:15174056, UniMod:353] comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" synonym: "Lysbiotinhydrazide" RELATED UniMod-interim [] synonym: "oxidized Lysine biotinylated with biotin hydrazide" RELATED UniMod-description [] xref: DiffAvg: "241.31" xref: DiffFormula: "C 10 H 15 N 3 O 2 S 1" xref: DiffMono: "241.088498" xref: Formula: "C 16 H 27 N 5 O 3 S 1" xref: MassAvg: "369.48" xref: MassMono: "369.183461" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00574 name: oxidized proline biotinylated with biotin hydrazide def: "modification from UniMod Chemical derivative" [PubMed:15174056, UniMod:357] comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" synonym: "oxidized proline biotinylated with biotin hydrazide" RELATED UniMod-description [] synonym: "probiotinhydrazide" RELATED UniMod-interim [] xref: DiffAvg: "258.34" xref: DiffFormula: "C 10 H 18 N 4 O 2 S 1" xref: DiffMono: "258.115047" xref: Formula: "C 15 H 25 N 5 O 3 S 1" xref: MassAvg: "355.46" xref: MassMono: "355.167811" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00575 name: oxidized threonine biotinylated with biotin hydrazide def: "modification from UniMod Chemical derivative" [PubMed:15174056, UniMod:361] comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" synonym: "oxidized Threonine biotinylated with biotin hydrazide" RELATED UniMod-description [] synonym: "Thrbiotinhydrazide" RELATED UniMod-interim [] xref: DiffAvg: "240.32" xref: DiffFormula: "C 10 H 16 N 4 O 1 S 1" xref: DiffMono: "240.104482" xref: Formula: "C 14 H 23 N 5 O 3 S 1" xref: MassAvg: "341.43" xref: MassMono: "341.152161" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00576 name: crotonaldehyde def: "modification from UniMod Other" [PubMed:11283024, UniMod:253] synonym: "Crotonaldehyde" RELATED PSI-MS-label [] synonym: "Crotonaldehyde" RELATED UniMod-description [] xref: DiffAvg: "70.09" xref: DiffFormula: "C 4 H 6 O 1" xref: DiffMono: "70.041865" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00577 name: acetaldehyde +26 def: "modification from UniMod Other" [PubMed:7744761, UniMod:254] synonym: "Acetaldehyde +26" RELATED UniMod-description [] synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "26.04" xref: DiffFormula: "C 2 H 2" xref: DiffMono: "26.015650" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00578 name: acetaldehyde +28 def: "modification from UniMod Other" [UniMod:255] synonym: "Acetaldehyde +28" RELATED UniMod-description [] synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00579 name: propionaldehyde +40 def: "modification from UniMod Other" [UniMod:256] synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label [] synonym: "Propionaldehyde +40" RELATED UniMod-description [] xref: DiffAvg: "40.06" xref: DiffFormula: "C 3 H 4" xref: DiffMono: "40.031300" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00580 name: propionaldehyde +42 def: "OBSOLETE because entry removed from UniMod. Remap potentially to MOD:00579 propionaldehyde +40" [UniMod:257] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6" xref: DiffMono: "42.046950" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00581 name: (18)O monosubstituted residue def: "A protein modification that effectively substitutes one (18)O atom for one (16)O atom." [OMSSA:87, PubMed:11467524, UniMod:258] subset: PSI-MOD-slim synonym: "ctermpepo18" EXACT OMSSA-label [] synonym: "Label:18O(1)" RELATED PSI-MS-label [] synonym: "O18 Labeling" RELATED UniMod-description [] xref: DiffAvg: "2.00" xref: DiffFormula: "(16)O -1 (18)O 1" xref: DiffMono: "2.004246" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:00845 ! (18)O substituted residue [Term] id: MOD:00582 name: 6x(13)C,2x(15)N labeled L-lysine def: "A protein modification that effectively converts an L-lysine residue to 6x(13)C,2x(15)N labeled L-lysine." [OMSSA:181, PubMed:12716131, UniMod:259] synonym: "13C(6) 15N(2) Silac label" RELATED UniMod-description [] synonym: "Label:13C(6)15N(2)" RELATED PSI-MS-label [] synonym: "lys-13C615N2" EXACT OMSSA-label [] xref: DiffAvg: "8.01" xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -2 (15)N 2" xref: DiffMono: "8.014199" xref: Formula: "(13)C 6 H 12 (15)N 2 O 1" xref: MassAvg: "136.11" xref: MassMono: "136.109162" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00842 ! (13)C labeled residue is_a: MOD:00843 ! (15)N labeled residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00583 name: thiophosphorylated residue def: "A protein modification that effectively replaces a hydrogen atom with a thiophosphono group (H2PO2S, 'thiophosphate')." [PubMed:12110917, UniMod:260] synonym: "Thiophospho" RELATED PSI-MS-label [] synonym: "Thiophosphorylation" RELATED UniMod-description [] xref: DiffAvg: "96.04" xref: DiffFormula: "H 1 O 2 P 1 S 1" xref: DiffMono: "95.943487" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00860 ! sulfur containing modified residue is_a: MOD:00861 ! phosphorus containing modified residue [Term] id: MOD:00584 name: 4-sulfophenyl isothiocyanate derivatized residue def: "A protein modification produced by formation of an adduct with 4-sulfophenyl isothiocyanate." [PubMed:14689565, PubMed:14745769, PubMed:16526082, UniMod:261] synonym: "4-sulfophenyl isothiocyanate" RELATED UniMod-description [] synonym: "SPITC" RELATED PSI-MS-label [] xref: DiffAvg: "215.24" xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2" xref: DiffMono: "214.971085" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00841 ! isothiocyanate reagent derivatized residue [Term] id: MOD:00585 name: deuterium trisubstituted residue def: "A protein modification that effectively substitutes three (2)H deuterium atoms for three (1)H protium atoms." [UniMod:262] synonym: "D(H)3Res" EXACT PSI-MOD-label [] synonym: "Label:2H(3)" RELATED PSI-MS-label [] synonym: "Trideuteration" RELATED UniMod-description [] xref: DiffAvg: "3.02" xref: DiffFormula: "(1)H -3 (2)H 3" xref: DiffMono: "3.018830" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00786 ! deuterium substituted residue [Term] id: MOD:00586 name: phosphorylation to pyridyl thiol def: "modification from UniMod Chemical derivative" [UniMod:264] synonym: "PET" RELATED PSI-MS-label [] synonym: "phosphorylation to pyridyl thiol" RELATED UniMod-description [] xref: DiffAvg: "121.20" xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1" xref: DiffMono: "121.035006" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00587 name: 6x(13)C,4x(15)N labeled L-arginine def: "A protein modification that effectively converts an L-arginine residue to 6x(13)C, 4x(15)N labeled L-arginine." [OMSSA:137, PubMed:12716131, UniMod:267] subset: PSI-MOD-slim synonym: "13C(6) 15N(4) Silac label" RELATED UniMod-description [] synonym: "arg-13c6-15n4" EXACT OMSSA-label [] synonym: "Label:13C(6)15N(4)" RELATED PSI-MS-label [] xref: DiffAvg: "10.01" xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -4 (15)N 4" xref: DiffMono: "10.008269" xref: Formula: "(13)C 6 H 12 (15)N 4 O 1" xref: MassAvg: "166.11" xref: MassMono: "166.109380" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00842 ! (13)C labeled residue is_a: MOD:00843 ! (15)N labeled residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00588 name: 5x(13)C,1x(15)N labeled L-valine def: "A protein modification that effectively converts an L-valine residue to 5x(13)C,1x(15)N labeled L-valine." [PubMed:12771378, UniMod:268#V] synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "6.01" xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" xref: DiffMono: "6.013809" xref: Formula: "(13)C 5 H 9 (15)N 1 O 1" xref: MassAvg: "105.08" xref: MassMono: "105.082223" xref: Origin: "V" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00920 ! modified L-valine residue is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue [Term] id: MOD:00589 name: 1x(13)C,1x(15)N labeled L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to (13)C,(15)N labeled L-phenylalanine." [PubMed:12771378, UniMod:269] synonym: "13C(9) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(9)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "10.03" xref: DiffFormula: "(12)C -9 (13)C 9 (14)N -1 (15)N 1" xref: DiffMono: "10.027228" xref: Formula: "(13)C 9 H 9 (15)N 1 O 1" xref: MassAvg: "157.10" xref: MassMono: "157.095642" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00842 ! (13)C labeled residue is_a: MOD:00843 ! (15)N labeled residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:00590 name: nucleophilic addtion to cytopiloyne def: "modification from UniMod Chemical derivative" [PubMed:15549660, UniMod:270] synonym: "Cytopiloyne" RELATED PSI-MS-label [] synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] xref: DiffAvg: "362.38" xref: DiffFormula: "C 19 H 22 O 7" xref: DiffMono: "362.136553" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00591 name: nucleophilic addition to cytopiloyne+H2O def: "modification from UniMod Chemical derivative" [PubMed:15549660, UniMod:271] synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] xref: DiffAvg: "380.39" xref: DiffFormula: "C 19 H 24 O 8" xref: DiffMono: "380.147118" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00592 name: sulfonation of N-terminal def: "modification from UniMod Chemical derivative" [PubMed:12705581, PubMed:15732931, PubMed:16046801, UniMod:272] synonym: "CAF" RELATED PSI-MS-label [] synonym: "sulfonation of N-terminus" RELATED UniMod-description [] xref: DiffAvg: "136.12" xref: DiffFormula: "C 3 H 4 O 4 S 1" xref: DiffMono: "135.983030" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00003 ! UniMod [Term] id: MOD:00593 name: covalent modification of lysine by omega-maleimido alkanoyl N-hydroxysuccinimido esters def: "modification from UniMod Chemical derivative" [UniMod:273] comment: J. Prot. Chem. 2, 263-277, 1983 synonym: "covalent modification of lysine by cross-linking reagent" RELATED UniMod-description [] synonym: "Xlink:SSD" RELATED PSI-MS-label [] xref: DiffAvg: "253.25" xref: DiffFormula: "C 12 H 15 N 1 O 5" xref: DiffMono: "253.095023" xref: Formula: "C 18 H 27 N 3 O 6" xref: MassAvg: "381.43" xref: MassMono: "381.189986" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00594 name: residues isobaric at 113.047678 Da def: "Natural or modified resiues with a mass of 113.047678 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da is_a: MOD:00624 ! residues isobaric at 113.0-113.1 Da [Term] id: MOD:00595 name: mannosylated residue def: "A protein modification that effectively replaces a hydrogen atom with an manose group through a glycosidic bond" [PubMed:18688235] subset: PSI-MOD-slim synonym: "ManRes" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00434 ! hexosylated residue is_a: MOD:00727 ! mannosylated [Term] id: MOD:00596 name: 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS." [DeltaMass:235, PubMed:8597590, UniMod:276] comment: From DeltaMass: Average Mass: 183 Average Mass Change:183 References:We have found that AEBSF modifies many proteins by covalent attachment, preferentially on Tyr, and to a lesser extent on Lys, His, and the amino-terminus. These modifications were identified by electrospray MS of the proteins (adds 183 Da per AEBS-group) and by peptide mapping and MS/MS. All the proteins we examined were modified after 24 hrs. at 4 C with 1 mM AEBSF in TRIS, pH 8.0. The reaction is 10-20x slower at pH 7; however AEBSF is quite stable in aqueous solution and the extent of to which the protein is modified continues to increase for several days. We have seen the addition of 10 or more AEBS-groups to proteins after prolonged storage. We found no equivalent modification from PMSF, probably because it degrades so quickly. We no longer use AEBSF, and urge caution to those who do. To address the problem, Boehringer Mannheim (now Roche Molecular Biochemicals) introduced Pefabloc PLUS which includes an additional component to compete for these side reactions. In our limited experience with Pefabloc PLUS, it reduces the +183 modifications, but does not always eliminate them. As a result, we prefer PMSF, despite its own set of drawbacks. We have never found PMSF-induced modification of proteins (except trypsin), probably due to its short half-life in aqeous solution. synonym: "AEBS" RELATED PSI-MS-label [] synonym: "AEBSF" EXACT DeltaMass-label [] synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] xref: DiffAvg: "183.23" xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" xref: DiffMono: "183.035400" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue [Term] id: MOD:00597 name: methyl methanethiosulfonate def: "OBSOLETE because UniMod entry 277 redundant with UniMod 39. Remap to MOD:00110." [UniMod:277] xref: DiffAvg: "46.09" xref: DiffFormula: "C 1 H 2 S 1" xref: DiffMono: "45.987721" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00598 name: S-(2-hydroxyethyl)cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(2-hydroxyethyl)cysteine" [PubMed:15351294, UniMod:278] comment: This modification of cysteine is produced by the reagent iodoethanol with triethylphosphine [JSG]. subset: PSI-MOD-slim synonym: "Ethanolation of Cys" RELATED UniMod-description [] synonym: "Ethanolyl" RELATED PSI-MS-label [] xref: DiffAvg: "44.05" xref: DiffFormula: "C 2 H 4 O 1" xref: DiffMono: "44.026215" xref: Formula: "C 5 H 9 N 1 O 2 S 1" xref: MassAvg: "147.19" xref: MassMono: "147.035400" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00599 name: monomethylated residue def: "A protein modification that effectively replaces one hydrogen atom with one methyl group." [PubMed:11875433, UniMod:34] subset: PSI-MOD-slim synonym: "Me1Res" EXACT PSI-MOD-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2" xref: DiffMono: "14.015650" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue [Term] id: MOD:00600 name: L-glutamic acid 5-ethyl ester def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-ethyl ester." [DeltaMass:0, PubMed:9629898, UniMod:280#E] comment: From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation. For dimethylated residues, see MOD:00429 and its children [JSG]. synonym: "Ethyl" EXACT DeltaMass-label [] synonym: "Ethyl" RELATED PSI-MS-label [] synonym: "Ethylation" RELATED UniMod-description [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "C 7 H 11 N 1 O 3" xref: MassAvg: "157.17" xref: MassMono: "157.073893" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01339 ! ethylated residue [Term] id: MOD:00601 name: cyclized residue def: "A protein modification that effectively produces an heterocyclic amino acid with a covalent bond between the side chain and either its alpha amino or 1-carboxyl group, possibly breaking the peptide chain." [PubMed:18688235] subset: PSI-MOD-slim synonym: "CycRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00602 name: N-methylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with an methyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NMeRes" EXACT PSI-MOD-label [] is_a: MOD:00427 ! methylated residue [Term] id: MOD:00603 name: N-ethylation def: "OBSOLETE because UniMod entry 283 is redundant with UniMod 280. Remap to MOD:00600" [UniMod:283] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_obsolete: true [Term] id: MOD:00604 name: 2x(2)H monomethylated L-lysine def: "A protein modification that effectively converts an L-lysine residue to 2x(2)H labeled monomethylated L-lysine." [PubMed:15525938, UniMod:284] synonym: "Deuterium Methylation of Lysine" RELATED UniMod-description [] synonym: "Methyl:2H(2)" RELATED PSI-MS-label [] xref: DiffAvg: "16.03" xref: DiffFormula: "C 1 (2)H 2" xref: DiffMono: "16.028204" xref: Formula: "C 7 (1)H 12 (2)H 2 N 2 O 1" xref: MassAvg: "144.12" xref: MassMono: "144.123167" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00839 ! (2)H deuterium labeled residue is_a: MOD:00912 ! modified L-lysine residue relationship: derives_from MOD:00085 ! N6-methyl-L-lysine [Term] id: MOD:00605 name: Sulfanilic Acid (SA), light C12 def: "modification from UniMod Chemical derivative, C-Terminal/Glutamate/Aspartate sulfonation" [UniMod:285] synonym: "Light Sulfanilic Acid (SA) C12" RELATED UniMod-description [] synonym: "SulfanilicAcid" RELATED PSI-MS-label [] xref: DiffAvg: "155.17" xref: DiffFormula: "C 6 H 5 N 1 O 2 S 1" xref: DiffMono: "155.004099" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00606 name: Sulfanilic Acid (SA), heavy C13 def: "modification from UniMod Chemical derivative" [PubMed:9254591, UniMod:286] synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED UniMod-description [] synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "161.02" xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1" xref: DiffMono: "161.024228" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00607 name: dioxoindolealanine lactone def: "modification from UniMod Chemical derivative" [PubMed:7949339, UniMod:288] comment: UniMod name, formula, and terminal specification corrected. Formula corresponded to uncleaved intermediate [JSG]. synonym: "Trp->Oxolactone" RELATED PSI-MS-label [] synonym: "Tryptophan oxidation to oxolactone" RELATED UniMod-description [] xref: DiffAvg: "30.99" xref: DiffFormula: "H -1 O 2" xref: DiffMono: "30.982004" xref: Formula: "C 11 H 9 N 2 O 3" xref: MassAvg: "217.20" xref: MassMono: "217.061317" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00608 name: biotin polyethyleneoxide amine def: "modification from UniMod Chemical derivative" [UniMod:289] synonym: "Biotin polyethyleneoxide amine" RELATED UniMod-description [] synonym: "Biotin-PEO-Amine" RELATED UniMod-interim [] xref: DiffAvg: "356.49" xref: DiffFormula: "C 16 H 28 N 4 O 3 S 1" xref: DiffMono: "356.188212" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00609 name: Pierce EZ-Link Biotin-HPDP def: "modification from UniMod Chemical derivative" [UniMod:290] synonym: "Biotin-HPDP" RELATED UniMod-interim [] synonym: "Pierce EZ-Link Biotin-HPDP" RELATED UniMod-description [] xref: DiffAvg: "428.61" xref: DiffFormula: "C 19 H 32 N 4 O 3 S 2" xref: DiffMono: "428.191583" xref: Formula: "C 22 H 37 N 5 O 4 S 3" xref: MassAvg: "531.75" xref: MassMono: "531.200768" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00610 name: cysteinyl mercury def: "modification from UniMod Chemical derivative" [PubMed:10695144, UniMod:291] synonym: "Delta:Hg(1)" RELATED PSI-MS-label [] synonym: "Mercury Mercaptan" RELATED UniMod-description [] xref: DiffAvg: "200.59" xref: DiffFormula: "Hg 1" xref: DiffMono: "201.970643" xref: Formula: "C 3 H 5 Hg 1 N 1 O 1 S 1" xref: MassAvg: "303.73" xref: MassMono: "304.979828" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01075 ! mercury containing modified residue [Term] id: MOD:00611 name: iodouridine monophosphate derivatized residue def: "A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with a residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, UniMod:292] synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED UniMod-description [] synonym: "IodoU-AMP" RELATED PSI-MS-label [] xref: DiffAvg: "322.17" xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1" xref: DiffMono: "322.020217" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00612 name: 3-(carboxamidomethylthio)propanoylated residue def: "A protein modification that is produced by derivatization of a residue with 3,3-dithiobis[sulfosuccinimidyl propanoate], DTSSP, or with Pierce EZ-Link Sulfo-NHS-SS-Biotin reagent, sulfosuccinimidyl 3-[(2-[biotinamido]ethyl)disulfanyl]propanoate, followed by reduction with dithiothreitol and then reaction with iodoacetamide." [PubMed:15121203, UniMod:293] synonym: "3-(carbamidomethylthio)propanoyl" RELATED UniMod-description [] synonym: "CAMthiopropanoyl" RELATED PSI-MS-label [] xref: DiffAvg: "145.18" xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1" xref: DiffMono: "145.019749" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00613 name: biotinoyl-iodoacetyl-ethylenediamine def: "modification from UniMod Chemical derivative" [PubMed:10906242, UniMod:294] synonym: "biotinoyl-iodoacetyl-ethylenediamine" RELATED UniMod-description [] synonym: "IED-Biotin" RELATED PSI-MS-label [] xref: DiffAvg: "326.42" xref: DiffFormula: "C 14 H 22 N 4 O 3 S 1" xref: DiffMono: "326.141262" xref: Formula: "C 17 H 27 N 5 O 4 S 2" xref: MassAvg: "429.55" xref: MassMono: "429.150446" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00614 name: fucosylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a fucose (6-deoxy-D-galactose) group through a glycosidic bond." [PubMed:11344537, PubMed:15189151, UniMod:295] subset: PSI-MOD-slim synonym: "dHex" RELATED PSI-MS-label [] synonym: "Fuc" EXACT PSI-MOD-label [] synonym: "Fucose" RELATED UniMod-description [] xref: DiffAvg: "146.14" xref: DiffFormula: "C 6 H 10 O 4" xref: DiffMono: "146.057909" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00736 ! deoxyhexosylated [Term] id: MOD:00615 name: 4-sulfophenyl isothiocyante modification to N-term R def: "OBSOLETE because entry UniMod:261 site N-term R was abandoned. Remap to MOD:00584" [PubMed:14689565, UniMod:261] xref: DiffAvg: "215.24" xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2" xref: DiffMono: "214.971085" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "N-term" is_obsolete: true [Term] id: MOD:00616 name: residues isobaric at a resolution below 0.1 Da def: "Natural or modified residues that are isobaric at a resolution below 0.1 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00538 ! protein modification categorized by isobaric sets [Term] id: MOD:00617 name: 3x(2)H residue methyl ester def: "A protein modification that effectively converts a residue containing common isotopes to a 3x(2)H labeled residue methyl ester." [OMSSA:21, UniMod:298] synonym: "ctermpeptrideuteromethyl" EXACT OMSSA-label [] synonym: "deuterated methyl ester" RELATED UniMod-description [] synonym: "Methyl:2H(3)" RELATED PSI-MS-label [] xref: DiffAvg: "17.03" xref: DiffFormula: "C 1 (1)H -1 (2)H 3" xref: DiffMono: "17.034480" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "C-term" is_a: MOD:00839 ! (2)H deuterium labeled residue [Term] id: MOD:00618 name: tryptophan carboxylation def: "modification from UniMod Chemical derivative" [UniMod:299#W] comment: There is no literature citation for this UniMod entry [JSG]. synonym: "Carboxy" RELATED UniMod-interim [] synonym: "Carboxylation" RELATED UniMod-description [] xref: DiffAvg: "44.01" xref: DiffFormula: "C 1 O 2" xref: DiffMono: "43.989829" xref: Formula: "C 12 H 10 N 2 O 3" xref: MassAvg: "230.22" xref: MassMono: "230.069142" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00918 ! modified L-tryptophan residue is_a: MOD:01152 ! carboxylated residue [Term] id: MOD:00619 name: hydroxylethanone def: "OBSOLETE because entry 300 is redundant with UniMod 6 remap to MOD:01328" [UniMod:300] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 O 2" xref: DiffMono: "58.005479" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00620 name: cysteine monobromobimane derivative def: "modification from UniMod Chemical derivative" [PubMed:7856876, UniMod:301] comment: 1-(bromomethyl)-2,6,7-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione, C 10 H 11 Br 1 N 2 O 2. synonym: "Bromobimane" RELATED PSI-MS-label [] synonym: "Monobromobimane derivative" RELATED UniMod-description [] xref: DiffAvg: "190.20" xref: DiffFormula: "C 10 H 10 N 2 O 2" xref: DiffMono: "190.074228" xref: Formula: "C 13 H 15 N 3 O 3 S 1" xref: MassAvg: "293.34" xref: MassMono: "293.083412" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00621 name: menadione quinone derivative def: "modification from UniMod Chemical derivative" [PubMed:15939799, UniMod:302] synonym: "Menadione" RELATED UniMod-interim [] synonym: "Menadione quinone derivative" RELATED UniMod-description [] xref: DiffAvg: "170.17" xref: DiffFormula: "C 11 H 6 O 2" xref: DiffMono: "170.036779" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00622 name: cysteine mercaptoethanol def: "modification from UniMod Chemical derivative" [DeltaMass:80, PubMed:12442261, UniMod:303] comment: From DeltaMass: Average Mass: 76 Average Mass Change:76 PubMed:8019414. synonym: "Beta mercaptoethanol adduct" EXACT DeltaMass-label [] synonym: "Cysteine mercaptoethanol" RELATED UniMod-description [] synonym: "DeStreak" RELATED PSI-MS-label [] xref: DiffAvg: "76.11" xref: DiffFormula: "C 2 H 4 O 1 S 1" xref: DiffMono: "75.998286" xref: Formula: "C 5 H 9 N 1 O 2 S 2" xref: MassAvg: "179.25" xref: MassMono: "179.007471" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00623 name: fucosylated biantennary (-2 galactose) def: "modification from UniMod N-linked glycosylation" [UniMod:305] synonym: "dHex(1)Hex(3)HexNAc(4)" RELATED PSI-MS-label [] synonym: "Fucosylated biantennary (-2 galactose)" RELATED UniMod-description [] xref: DiffAvg: "1443.33" xref: DiffFormula: "C 56 H 90 N 4 O 39" xref: DiffMono: "1442.518219" xref: Formula: "C 60 H 96 N 6 O 41" xref: MassAvg: "1557.43" xref: MassMono: "1556.561147" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00624 name: residues isobaric at 113.0-113.1 Da def: "Natural or modified residues with a mass of 113.0-113.1 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da [Term] id: MOD:00625 name: N-methylmaleimide derivatized residue def: "modification from UniMod Chemical derivative" [UniMod:314] synonym: "Nmethylmaleimide" RELATED PSI-MS-label [] synonym: "Nmethylmaleimide" RELATED UniMod-description [] xref: DiffAvg: "111.10" xref: DiffFormula: "C 5 H 5 N 1 O 2" xref: DiffMono: "111.032028" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00626 name: fluorescein-5-thiosemicarbazide def: "modification from UniMod Chemical derivative" [PubMed:2883911, UniMod:478] synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] synonym: "FTC" RELATED PSI-MS-label [] xref: DiffAvg: "421.43" xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" xref: DiffMono: "421.073242" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00627 name: 2,5-dimethylpyrrole lysine from 2,5-hexanedione adduct def: "modification from UniMod Chemical derivative" [UniMod:316] comment: There is no citation for this UniMod entry. Add PubMed:7981420, correct spelling [JSG]. synonym: "(2S)-2-amino-6-(2,5-dimethylpyrrolidin-1-yl)hexanoic acid" EXACT PSI-MOD-alternate [] synonym: "2,5-dimethypyrrole" RELATED UniMod-description [] synonym: "6-(2,5-dimethylpyrrolidin-1-yl)norleucine" EXACT PSI-MOD-alternate [] synonym: "DimethylpyrroleAdduct" RELATED PSI-MS-label [] xref: DiffAvg: "78.11" xref: DiffFormula: "C 6 H 6" xref: DiffMono: "78.046950" xref: Formula: "C 12 H 18 N 2 O 1" xref: MassAvg: "206.29" xref: MassMono: "206.141913" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00628 name: Hex2 def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with two hexose sugar groups through glycosidic bonds" [PubMed:18688235] xref: DiffAvg: "324.28" xref: DiffFormula: "C 12 H 20 O 10" xref: DiffMono: "324.105647" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:00629 name: MDA adduct +62 def: "modification from UniMod Chemical derivative" [UniMod:318] comment: Usually major adduct formed from malondialdehyde (MDA) with the amino group of lysine residues [UniProt]. synonym: "Delta:H(2)C(5)" RELATED PSI-MS-label [] synonym: "MDA adduct +62" RELATED UniMod-description [] xref: DiffAvg: "62.07" xref: DiffFormula: "C 5 H 2" xref: DiffMono: "62.015650" xref: Formula: "C 11 H 14 N 2 O 1" xref: MassAvg: "190.25" xref: MassMono: "190.110613" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00630 name: C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. def: "modification from UniMod Chemical derivative" [PubMed:9328283, UniMod:319] comment: This is not a legitimate ontological entry and will become obsolete when the children are reassigned [JSG] synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label [] synonym: "MDA adduct +54" RELATED UniMod-description [] xref: DiffAvg: "54.05" xref: DiffFormula: "C 3 H 2 O 1" xref: DiffMono: "54.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00631 name: hydrolyzed N-ethylmaleimide adduct def: "modification from UniMod Chemical derivative" [UniMod:320] comment: N-ethylmaeimide adduct + H20 (a mixture of isobaric products) [JSG]. synonym: "Nethylmaleimide+water" RELATED PSI-MS-label [] synonym: "Nethylmaleimidehydrolysis" RELATED UniMod-description [] xref: DiffAvg: "143.14" xref: DiffFormula: "C 6 H 9 N 1 O 3" xref: DiffMono: "143.058243" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00632 name: N-succinimide def: "OBSOLETE because this chemical derivative modification from UniMod 321 is deprecated." [UniMod:321] xref: DiffAvg: "-17.01" xref: DiffFormula: "H -1 O -1" xref: DiffMono: "-17.002740" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00633 name: bis-N-I-sulfonerahodamine def: "modification from UniMod Chemical derivative" [UniMod:323] comment: Invitrogen B-10621, a red fluorescent cross-linking reagent (only link to Cys is indicated) [UniMod]. synonym: "bis-((N-iodoacetyl)piperazinyl)sulfonerhodamine" EXACT PSI-MOD-alternate [] synonym: "bis-N-I-sulfonerahodamine" RELATED UniMod-description [] synonym: "Xlink:B10621" RELATED PSI-MS-label [] xref: DiffAvg: "713.57" xref: DiffFormula: "C 31 H 30 I 1 N 4 O 6 S 1" xref: DiffMono: "713.093078" xref: Formula: "C 34 H 35 I 1 N 5 O 7 S 2" xref: MassAvg: "816.71" xref: MassMono: "816.102263" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00634 name: dimethyl 3,3'-dithiobispropionimidate def: "modification from UniMod Chemical derivative" [PubMed:770170, UniMod:324] comment: Pierce reagent, needs sites for N, Q, R, K, and N-term [JSG]. synonym: "dimethyl 3,3'-dithiobispropionimidate" RELATED UniMod-description [] synonym: "DTBP" RELATED UniMod-interim [] xref: DiffAvg: "123.60" xref: DiffFormula: "C 3 Cl 1 H 6 N 1 S 1" xref: DiffMono: "122.990948" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00635 name: 10-fluoroethoxyphosphinyl-N-(biotinamidopentyl)decanamide def: "modification from UniMod Chemical derivative" [PubMed:10611275, UniMod:325] synonym: "10-ethoxyphosphinyl-N-(biotinamidopentyl)decanamide" RELATED UniMod-description [] synonym: "FP-Biotin" RELATED UniMod-interim [] xref: DiffAvg: "572.75" xref: DiffFormula: "C 27 H 49 N 4 O 5 P 1 S 1" xref: DiffMono: "572.316128" xref: Formula: "C 30 H 54 N 5 O 7 P 1 S 1" xref: MassAvg: "659.82" xref: MassMono: "659.348157" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00636 name: S-ethylcysteine (Ser) def: "A protein modification that effectively converts an L-serine residue to S-ethylcysteine." [UniMod:327] comment: Modification from UniMod. Phosphoserine is converted to dehydroalanine then by Michael addition of ethanethiol to S-ethylcysteine. Needs parent and sibling for S-ethyl-cysteine. synonym: "Delta:H(4)C(2)O(-1)S(1)" RELATED PSI-MS-label [] synonym: "S-Ethylcystine from Serine" RELATED UniMod-description [] xref: DiffAvg: "44.11" xref: DiffFormula: "C 2 H 4 O -1 S 1" xref: DiffMono: "44.008457" xref: Formula: "C 5 H 9 N 1 O 1 S 1" xref: MassAvg: "131.19" xref: MassMono: "131.040485" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00637 name: 1x(13)C,3x(2)H labeled monomethylated L-arginine def: "A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with a (13)C,3x(2)H labeled methyl group to form a 1x(13)C,3x(2)H labeled monomethylated L-arginine." [UniMod:329] synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label [] synonym: "monomethylated arginine" RELATED UniMod-description [] xref: DiffAvg: "18.04" xref: DiffFormula: "(13)C 1 (1)H -1 (2)H 3" xref: DiffMono: "18.037835" xref: Formula: "(12)C 6 (13)C 1 (1)H 11 (2)H 3 N 4 O 1" xref: MassAvg: "174.14" xref: MassMono: "174.138946" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00839 ! (2)H deuterium labeled residue is_a: MOD:00842 ! (13)C labeled residue is_a: MOD:00902 ! modified L-arginine residue relationship: derives_from MOD:00414 ! monomethylated L-arginine [Term] id: MOD:00638 name: 2x(13)C,6x(2)H labeled dimethylated L-arginine def: "A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-arginine." [PubMed:15782174, UniMod:330] synonym: "Dimethyl:2H(6)13C(2)" RELATED PSI-MS-label [] synonym: "dimethylated arginine" RELATED UniMod-description [] xref: DiffAvg: "36.08" xref: DiffFormula: "(13)C 2 (1)H -2 (2)H 6" xref: DiffMono: "36.075670" xref: Formula: "(12)C 6 (13)C 2 (1)H 10 (2)H 6 N 4 O 1" xref: MassAvg: "192.18" xref: MassMono: "192.176781" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00839 ! (2)H deuterium labeled residue is_a: MOD:00842 ! (13)C labeled residue is_a: MOD:00902 ! modified L-arginine residue relationship: derives_from MOD:00783 ! dimethylated L-arginine [Term] id: MOD:00639 name: thiophosphate labeled with biotin-HPDP def: "modification from UniMod Chemical derivative" [UniMod:332] synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label [] synonym: "thiophosphate labeled with biotin-HPDP" RELATED UniMod-description [] xref: DiffAvg: "525.66" xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3" xref: DiffMono: "525.142895" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00861 ! phosphorus containing modified residue [Term] id: MOD:00640 name: 6-N-biotinylaminohexyl isopropyl phosphorofluoridate def: "modification from UniMod Chemical derivative" [UniMod:333] synonym: "6-N-biotinylaminohexyl isopropyl phosphate" RELATED UniMod-description [] synonym: "Can-FP-biotin" RELATED UniMod-interim [] xref: DiffAvg: "467.54" xref: DiffFormula: "C 19 F 1 H 35 N 3 O 5 P 1 S 1" xref: DiffMono: "467.201907" xref: Formula: "C 22 F 1 H 40 N 4 O 7 P 1 S 1" xref: MassAvg: "554.62" xref: MassMono: "554.233935" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00641 name: CAMthiopropanoyl of Lys def: "OBSOLETE because UniMod entry 334 is merged with UniMod 293. Remap to MOD:00612" [UniMod:334] xref: DiffAvg: "146.18" xref: DiffFormula: "C 5 H 8 N 1 O 2 S 1" xref: DiffMono: "146.027574" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00642 name: reduced 4-hydroxynonenal adduct def: "A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:15133838, UniMod:335] comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label [] synonym: "reduced 4-Hydroxynonenal" RELATED UniMod-description [] xref: DiffAvg: "158.24" xref: DiffFormula: "C 9 H 18 O 2" xref: DiffMono: "158.130680" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:01155 ! lipoconjugated residue relationship: derives_from MOD:00446 ! 4-hydroxynonenal adduct [Term] id: MOD:00643 name: methylamine Michael addition derivatized residue def: "modification from UniMod Artifact" [PubMed:11968134, UniMod:337] synonym: "Methylamine" RELATED PSI-MS-label [] synonym: "Michael addition with methylamine" RELATED UniMod-description [] xref: DiffAvg: "13.04" xref: DiffFormula: "C 1 H 3 N 1 O -1" xref: DiffMono: "13.031634" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00003 ! UniMod [Term] id: MOD:00644 name: O-acetylated residue def: "A protein modification that effectively replaces a residue hydroxyl group with an acetoxy group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OAcRes" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 O 1" xref: DiffMono: "42.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00394 ! acetylated residue is_a: MOD:00671 ! O-acylated residue [Term] id: MOD:00645 name: S-acetylated residue def: "A protein modification that effectively replaces a residue sulfanyl group with an acetylsulfanyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "SAcRes" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 O 1 S 0" xref: DiffMono: "42.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00394 ! acetylated residue is_a: MOD:00672 ! S-acylated residue [Term] id: MOD:00646 name: acetylated L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to either N-acetyl-L-cysteine or S-acetyl-L-cysteine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "AcCys" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0" xref: DiffMono: "42.010565" xref: Formula: "C 5 H 7 N 1 O 2 S 1" xref: MassAvg: "145.18" xref: MassMono: "145.019749" xref: Origin: "C" xref: Source: "natural" is_a: MOD:00394 ! acetylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00647 name: acetylated L-serine def: "A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "AcSer" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "S" xref: Source: "natural" is_a: MOD:00394 ! acetylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00648 name: N,O-diacetylated L-serine def: "A protein modification that effectively converts an L-serine residue to N,O-diacetyl-L-serine." [PubMed:16731519, PubMed:489587, PubMed:7309355, RESID:AA0051#var, RESID:AA0364#var] comment: The samples were prepared using glacial acetic acid, and were probably artifactual [JSG]. synonym: "(S)-2-acetamido-3-acetyloxypropanoic acid" EXACT PSI-MOD-alternate [] synonym: "N,O-diacetyl-L-serine" EXACT PSI-MOD-alternate [] synonym: "N,O-diacetylserine" EXACT PSI-MOD-alternate [] synonym: "NOAc2Ser" EXACT PSI-MOD-label [] xref: DiffAvg: "84.07" xref: DiffFormula: "C 4 H 4 N 0 O 2" xref: DiffMono: "84.021129" xref: Formula: "C 7 H 10 N 1 O 4" xref: MassAvg: "172.16" xref: MassMono: "172.060983" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00408 ! N-acetylated residue is_a: MOD:00644 ! O-acetylated residue is_a: MOD:00647 ! acetylated L-serine relationship: has_functional_parent MOD:00060 ! N-acetyl-L-serine relationship: has_functional_parent MOD:00369 ! O-acetyl-L-serine [Term] id: MOD:00649 name: acylated residue def: "A protein modification that effectively replaces a hydrogen atom with an acyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "AcylRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00650 name: N-myristoylated residue def: "A protein modification that effectively replaces a residue amino group with a myristoylamino group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NMyrRes" EXACT PSI-MOD-label [] xref: DiffAvg: "210.36" xref: DiffFormula: "C 14 H 26 O 1" xref: DiffMono: "210.198365" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00438 ! myristoylated residue is_a: MOD:00670 ! N-acylated residue [Term] id: MOD:00651 name: N-palmitoylated residue def: "A protein modification that effectively replaces a residue amino group with a palmitoylamino group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NPamRes" EXACT PSI-MOD-label [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 O 1" xref: DiffMono: "238.229666" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00440 ! palmitoylated residue is_a: MOD:00670 ! N-acylated residue [Term] id: MOD:00652 name: O-palmitoylated residue def: "A protein modification that effectively replaces a residue hydroxyl group with a palmitoyloxy group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OPamRes" EXACT PSI-MOD-label [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 O 1" xref: DiffMono: "238.229666" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00440 ! palmitoylated residue is_a: MOD:00671 ! O-acylated residue [Term] id: MOD:00653 name: S-palmitoylated residue def: "A protein modification that effectively replaces a residue sulfanyl group with an palmitoylsulfanyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "SPamRes" EXACT PSI-MOD-label [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 O 1 S 0" xref: DiffMono: "238.229666" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00440 ! palmitoylated residue is_a: MOD:00672 ! S-acylated residue [Term] id: MOD:00654 name: S-methylated residue def: "a protein modification that effectively replaces a sulfanyl group with a methylsulfanyl group" [PubMed:18688235] subset: PSI-MOD-slim synonym: "SMeRes" EXACT PSI-MOD-label [] is_a: MOD:00427 ! methylated residue [Term] id: MOD:00655 name: S-myristoylated residue def: "A protein modification that effectively replaces a residue sulfanyl group with an myristoylsulfanyl group." [PubMed:18688235] synonym: "SMyrRes" EXACT PSI-MOD-label [] xref: DiffAvg: "210.36" xref: DiffFormula: "C 14 H 26 O 1 S 0" xref: DiffMono: "210.198365" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00438 ! myristoylated residue is_a: MOD:00672 ! S-acylated residue [Term] id: MOD:00656 name: C-methylated residue def: "A protein modification that effectively replaces a residue hydrocarbyl hydrogen with an methyl group." [PubMed:18688235] synonym: "CMeRes" EXACT PSI-MOD-label [] is_a: MOD:00427 ! methylated residue [Term] id: MOD:00657 name: L-glutamic acid 5-methyl ester (Gln) def: "A protein modification that effectively converts an L-glutamine residue to L-glutamate 5-methyl ester." [PubMed:16888, PubMed:6300110, RESID:AA0072#GLN, UniMod:528] comment: This is known to be a natural modification of glutamine in prokaryotes. subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate [] synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate [] synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate [] synonym: "5-methyl L-glutamate" EXACT RESID-alternate [] synonym: "deamidated 5-methyl esterified glutamine" EXACT PSI-MOD-alternate [] synonym: "Deamidation followed by a methylation" RELATED UniMod-description [] synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate [] synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate [] synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name [] synonym: "Methyl+Deamidated" RELATED PSI-MS-label [] synonym: "MOD_RES Glutamate methyl ester (Gln)" EXACT UniProt-feature [] synonym: "O5MeGlu(Gln)" EXACT PSI-MOD-label [] xref: DiffAvg: "15.01" xref: DiffFormula: "C 1 H 1 N -1 O 1" xref: DiffMono: "14.999666" xref: Formula: "C 6 H 9 N 1 O 3" xref: MassAvg: "143.14" xref: MassMono: "143.058243" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01369 ! deamidated and methyl esterified residue is_a: MOD:01453 ! L-glutamic acid 5-methyl ester relationship: has_functional_parent MOD:00659 ! methylated glutamine [Term] id: MOD:00658 name: methylated arginine def: "A protein modification that effectively converts an L-arginine residue to a methylated arginine, either 5-methylargine, N5-methylarginine, or an omega-N-methylated L-arginine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeArg" EXACT PSI-MOD-label [] xref: Origin: "R" is_a: MOD:00427 ! methylated residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00659 name: methylated glutamine def: "A protein modification that effectively converts an L-glutamine residue to a methylated glutamine, either 2-methylated glutamine, N5-methylated glutamine, or methyl esterified deamidated glutamine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeGln" EXACT PSI-MOD-label [] xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00907 ! modified L-glutamine residue [Term] id: MOD:00660 name: methylated cysteine def: "A protein modification that effectively converts an L-cysteine residue to a methylated cysteine, either S-methylcysteine, or cysteine methyl ester." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeCys" EXACT PSI-MOD-label [] xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00661 name: methylated histidine def: "A protein modification that effectively converts an L-histidine residue to a methylated histidine, such as pros-methylhistidine, or tele-methylhistidine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeHis" EXACT PSI-MOD-label [] xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00662 name: methylated leucine def: "A protein modification that effectively converts an L-leucine residue to a methylated leucine, either N-methylleucine, or leucine methyl ester." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeLeu" EXACT PSI-MOD-label [] xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00911 ! modified L-leucine residue [Term] id: MOD:00663 name: methylated lysine def: "A protein modification that effectively converts an L-lysine residue to a methylated lysine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeLys" EXACT PSI-MOD-label [] xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00664 name: stereoisomerized residue def: "A protein modification that effectively replaces a residue L-enantiomer (stereoisomer) with a D-enantiomer or with a different diastereomeric isomer." [PubMed:18688235] synonym: "D-Res" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00665 name: methylated alanine def: "A protein modification that effectively converts an L-alanine residue to a methylated alanine, such as N-methylalanine, N,N-dimethylalanine, or N,N,N-trimethylalanine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeAla" EXACT PSI-MOD-label [] xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00901 ! modified L-alanine residue [Term] id: MOD:00666 name: octanoylated residue def: "A protein modification that effectively replaces a hydrogen atom with an octanoyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OctRes" EXACT PSI-MOD-label [] xref: DiffAvg: "126.20" xref: DiffFormula: "C 8 H 14 N 0 O 1" xref: DiffMono: "126.104465" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00667 name: decanoylated residue def: "A protein modification that effectively replaces a hydrogen atom with a decanoyl group." [PubMed:18688235] synonym: "DecRes" EXACT PSI-MOD-label [] xref: DiffAvg: "154.25" xref: DiffFormula: "C 10 H 18 N 0 O 1" xref: DiffMono: "154.135765" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00668 name: O-decanoylated residue def: "A protein modification that effectively replaces a residue hydroxyl group with a decanoyloxy group." [UniMod:449] synonym: "Decanoyl" RELATED PSI-MS-label [] synonym: "lipid" RELATED UniMod-description [] synonym: "ODecRes" EXACT PSI-MOD-label [] xref: DiffAvg: "154.25" xref: DiffFormula: "C 10 H 18 N 0 O 1" xref: DiffMono: "154.135765" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00667 ! decanoylated residue is_a: MOD:00671 ! O-acylated residue [Term] id: MOD:00669 name: O-octanoylated residue def: "A protein modification that effectively replaces a residue hydroxyl group with a octanoyloxy group." [UniMod:426] subset: PSI-MOD-slim synonym: "Octanoyl" RELATED PSI-MS-label [] synonym: "octanoyl" RELATED UniMod-description [] synonym: "OOctRes" EXACT PSI-MOD-label [] xref: DiffAvg: "126.20" xref: DiffFormula: "C 8 H 14 N 0 O 1" xref: DiffMono: "126.104465" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00666 ! octanoylated residue is_a: MOD:00671 ! O-acylated residue [Term] id: MOD:00670 name: N-acylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NAcylRes" EXACT PSI-MOD-label [] is_a: MOD:00649 ! acylated residue [Term] id: MOD:00671 name: O-acylated residue def: "A protein modification that effectively replaces a residue hydroxyl group with a acyloxy group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OAcylRes" EXACT PSI-MOD-label [] is_a: MOD:00649 ! acylated residue [Term] id: MOD:00672 name: S-acylated residue def: "A protein modification that effectively replaces a residue sulfanyl group with an acylsulfanyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "SAcylRes" EXACT PSI-MOD-label [] is_a: MOD:00649 ! acylated residue [Term] id: MOD:00673 name: methylated asparagine def: "A protein modification that effectively converts an L-asparagine residue to a methylated asparagine, such as N4-methyl-L-asparagine, or N4,N4-dimethyl-L-asparagine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeAsn" EXACT PSI-MOD-label [] xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00674 name: amidated residue def: "A protein modification that effectively replaces a carboxyl group with a carboxamido group." [PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00675 name: oxidized residue def: "A protein modification that effectively either removes neutral hydrogen atoms (proton and electron), or adds oxygen atoms to a residue with or without the removal of hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OxRes" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00676 name: oxygenated residue def: "A protein modification that effectively adds oxygen atoms to a residue with or without the removal of hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OxyRes" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00675 ! oxidized residue [Term] id: MOD:00677 name: hydroxylated residue def: "A protein modification that effectively replaces a hydrogen atom with an hydroxyl group." [DeltaMass:0] comment: From DeltaMass: Average Mass: 16 subset: PSI-MOD-slim synonym: "Hydroxylation (of delta C of Lysine, beta C of Tryptophan, C3 or C4 of Proline, beta C of Aspartate)" EXACT DeltaMass-label [] synonym: "HyRes" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue [Term] id: MOD:00678 name: hydroxylated proline def: "A protein modification that effectively converts an L-proline residue to an hydroxylated L-proline." [PubMed:18688235] subset: PSI-MOD-slim synonym: "HyPro" EXACT PSI-MOD-label [] xref: Origin: "P" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:00679 name: carbon oxygenated residue def: "A protein modification that effectively adds oxygen atoms to a carbon atom of a residue and removes hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "COxyRes" EXACT PSI-MOD-label [] is_a: MOD:00676 ! oxygenated residue [Term] id: MOD:00680 name: sulfur oxygenated residue def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "SOxyRes" EXACT PSI-MOD-label [] is_a: MOD:00676 ! oxygenated residue [Term] id: MOD:00681 name: hydroxylated lysine def: "A protein modification that effectively converts an L-lysine residue to a hydroxylated L-lysine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "HyLys" EXACT PSI-MOD-label [] xref: Origin: "K" is_a: MOD:00677 ! hydroxylated residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00682 name: hydroxylated arginine def: "A protein modification that effectively converts an L-arginine residue to a hydroxylated L-arginine." [PubMed:18688235] synonym: "HyArg" EXACT PSI-MOD-label [] xref: Origin: "R" is_a: MOD:00677 ! hydroxylated residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00683 name: dehydrogenated residue def: "A protein modification that effectively removes neutral hydrogen atoms (proton and electron) from a residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "dHRes" EXACT PSI-MOD-label [] xref: Origin: "X" is_a: MOD:00675 ! oxidized residue [Term] id: MOD:00684 name: deamidated L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid." [PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, RESID:AA0004#ASN, UniMod:7#N] comment: incidental to RESID:AA0059 subset: PSI-MOD-slim synonym: "(2S)-2-aminobutanedioic acid" EXACT RESID-systematic [] synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] synonym: "aminosuccinic acid" EXACT RESID-alternate [] synonym: "dNAsn" EXACT PSI-MOD-label [] synonym: "L-aspartic acid" EXACT RESID-name [] synonym: "MOD_RES Deamidated asparagine" EXACT UniProt-feature [] xref: DiffAvg: "0.98" xref: DiffFormula: "C 0 H -1 N -1 O 1" xref: DiffMono: "0.984016" xref: Formula: "C 4 H 5 N 1 O 3" xref: MassAvg: "115.09" xref: MassMono: "115.026943" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00013 ! L-aspartic acid residue is_a: MOD:00400 ! deamidated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00685 name: deamidated L-glutamine def: "A protein modification that effectively converts an L-glutamine residue to L-glutamic acid." [PubMed:1881881, PubMed:4565668, PubMed:4922541, PubMed:6692818, PubMed:9192900, PubMed:957425, RESID:AA0006#GLN, UniMod:7#Q] subset: PSI-MOD-slim synonym: "(2S)-2-aminopentanedioic acid" EXACT RESID-systematic [] synonym: "1-aminopropane-1,3-dicarboxylic acid" EXACT RESID-alternate [] synonym: "2-aminoglutaric acid" EXACT RESID-alternate [] synonym: "2-azanylpentanedioic acid" EXACT RESID-alternate [] synonym: "alpha-aminoglutaric acid" EXACT RESID-alternate [] synonym: "dNGln" EXACT PSI-MOD-label [] synonym: "glutaminic acid" EXACT RESID-alternate [] synonym: "L-glutamic acid" EXACT RESID-name [] synonym: "MOD_RES Deamidated glutamine" EXACT UniProt-feature [] xref: DiffAvg: "0.98" xref: DiffFormula: "C 0 H -1 N -1 O 1" xref: DiffMono: "0.984016" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00015 ! L-glutamic acid residue is_a: MOD:00400 ! deamidated residue [Term] id: MOD:00686 name: L-selenocysteine (Cys) def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteine (not known as a natural, post-translational modification process)." [PubMed:10523135, PubMed:2037562, PubMed:2963330, PubMed:6217842, PubMed:6714945, RESID:AA0022#CYS, UniMod:162#C] comment: This entry is for the artifactual formation of L-selenocysteine from cysteine. For encoded L-selenocysteine, use MOD:00031 [JSG]. synonym: "(2R)-2-amino-3-selanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-selanylpropanoic acid" EXACT RESID-alternate [] synonym: "3-selenylalanine" EXACT RESID-alternate [] synonym: "L-selenocysteine" EXACT RESID-name [] synonym: "NON_STD Selenocysteine" EXACT UniProt-feature [] synonym: "Sec(Cys)" EXACT PSI-MOD-label [] synonym: "SeCys" EXACT RESID-alternate [] synonym: "selenium cysteine" EXACT RESID-alternate [] xref: DiffAvg: "46.91" xref: DiffFormula: "C 0 H 0 N 0 O 0 S -1 Se 1" xref: DiffMono: "47.944450" xref: Formula: "C 3 H 5 N 1 O 1 Se 1" xref: MassAvg: "150.05" xref: MassMono: "150.953635" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00007 ! selenium substitution for sulfur is_a: MOD:00031 ! L-selenocysteine residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00687 name: thioether crosslinked residues def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and either an alkyl C as in lanthionine, or an aryl C as 2'-(S-cysteinyl)-L-histidine." [PubMed:18688235] is_a: MOD:00033 ! crosslinked residues is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00688 name: isopeptide crosslinked residues def: "A protein modification that crosslinks two residues with an amide bond where either the donor amino or carboxyl is not an alpha group." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:00689 name: disulfide crosslinked residues def: "A protein modification that crosslinks two cysteine residues by formation of a disulfide bond." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01619 ! multisulfide crosslinked residues [Term] id: MOD:00690 name: oxazole/thiazole ring crosslinked residues def: "A protein modification that crosslinks two residues by formation of an oxazole or thiazole ring." [PubMed:18688235] is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:00691 name: 5-imidazolinone ring crosslinked residues def: "A protein modification that crosslinks two residues by formation of an 5-imidazolinone ring." [PubMed:18688235] is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:00692 name: uncategorized crosslinked residues def: "A protein crosslink modification that is not chemically categorized." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:00693 name: glycosylated residue def: "A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "GlycoRes" EXACT PSI-MOD-label [] xref: Source: "natural" is_a: MOD:00764 ! glycoconjugated residue [Term] id: MOD:00694 name: halogen containing residue def: "A protein modification that effectively substitutes a halogen atom for a hydrogen atom." [PubMed:18688235] subset: PSI-MOD-slim synonym: "halogenated residue" EXACT PSI-MOD-alternate [] synonym: "HalRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00695 name: sulfated residue def: "A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group." [DeltaMass:0, PubMed:14752058, UniMod:40] comment: From DeltaMass: Average Mass: 80. subset: PSI-MOD-slim synonym: "O-Sulfonation" RELATED UniMod-description [] synonym: "Sulfo" RELATED PSI-MS-label [] synonym: "SulfRes" EXACT PSI-MOD-label [] synonym: "Sulphonation (SO3H) (of PMC group)" EXACT DeltaMass-label [] xref: DiffAvg: "80.06" xref: DiffFormula: "O 3 S 1" xref: DiffMono: "79.956815" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00860 ! sulfur containing modified residue [Term] id: MOD:00696 name: phosphorylated residue def: "A protein modification that effectively replaces a hydrogen atom with a phosphono group (H2PO3 or 'phosphate')." [DeltaMass:0, UniMod:21] comment: From DeltaMass: Average Mass: 80. subset: PSI-MOD-slim synonym: "Phospho" RELATED PSI-MS-label [] synonym: "Phosphorylation" RELATED UniMod-description [] synonym: "Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine)" EXACT DeltaMass-label [] synonym: "PhosRes" EXACT PSI-MOD-label [] xref: DiffAvg: "79.98" xref: DiffFormula: "H 1 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00861 ! phosphorus containing modified residue [Term] id: MOD:00697 name: flavin modified residue def: "A protein modification that effectively results from forming an adduct with a compound containing a flavin group." [UniMod:50] subset: PSI-MOD-slim synonym: "FAD" RELATED PSI-MS-label [] synonym: "Flavin adenine dinucleotide" RELATED UniMod-description [] synonym: "FlavRes" EXACT PSI-MOD-label [] xref: DiffAvg: "783.54" xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2 S 0" xref: DiffMono: "783.141485" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00698 name: metal or metal cluster containing modified residue def: "A protein modification that effectively substitutes a metal atom or a metal cluster for hydrogen atoms, or coordinates a metal ion." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MetalRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00699 name: porphyrin modified residue def: "A protein modification that effectively results from forming an adduct with a compound containing a porphyrin group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "PorphRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00700 name: tetrapyrrole modified residue def: "A protein modification that effectively results from forming an adduct with a compound containing a tetrapyrrole group." [PubMed:18688235] synonym: "TetrapyrRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00701 name: nucleotide or nucleic acid modified residue def: "A protein modification that effectively results from forming an adduct with a compound containing a nucleotide or a polynucleotide through formation of either a phosphodiester bond, a phosphoramide ester bond, or a glycosidic bond." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NucRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00702 name: isotope labeled residue def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms or groups containing isotopes that are not the most common." [PubMed:18688235] comment: In SILAC (stable isotope labelling of amino acids in cell culture), the label may be introduced either through labeling of an incorporated residue or labeling of the substrates in a metabolic modification. For isotope labeling introduced through a modification reagent see MOD:01426. subset: PSI-MOD-slim synonym: "IsoTagRes" EXACT PSI-MOD-label [] synonym: "SILAC" EXACT PSI-MOD-alternate [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00703 name: isoprenylated residue def: "A protein modification that effectively replaces a hydrogen atom with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20) group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "IpRes" EXACT PSI-MOD-label [] is_a: MOD:00001 ! alkylated residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00704 name: dehydrated residue def: "A protein modification that effectively forms a double bond by removing a molecule of water from a residue." [DeltaMass:0, UniMod:23] subset: PSI-MOD-slim synonym: "Dehydrated" RELATED UniMod-interim [] synonym: "Dehydration" RELATED UniMod-description [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00705 name: D-valine def: "A protein modification that effectively converts an L-valine residue to D-valine." [ChEBI:30016, PubMed:15853325, RESID:AA0200] synonym: "(R)-2-amino-3-methylbutanoic acid" EXACT RESID-systematic [] synonym: "alpha-amino-beta-methylbutyric acid" EXACT RESID-alternate [] synonym: "alpha-aminoisovaleric acid" EXACT RESID-alternate [] synonym: "D-Val" EXACT PSI-MOD-label [] synonym: "D-valine" EXACT RESID-name [] synonym: "MOD_RES D-valine" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 5 H 9 N 1 O 1" xref: MassAvg: "99.13" xref: MassMono: "99.068414" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue [Term] id: MOD:00706 name: dehydrogenated tyrosine def: "A protein modification that effectively converts L-tyrosine to 2,3-didehydrotyrosine." [UniMod:401#Y] subset: PSI-MOD-slim synonym: "dHTyr" EXACT PSI-MOD-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 9 H 7 N 1 O 2" xref: MassAvg: "161.16" xref: MassMono: "161.047678" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00707 name: hydroxylated tyrosine def: "a protein modification that effectively converts an L-tyrosine residue to a multihydroxylated L-phenylalanine" [PubMed:18688235] subset: PSI-MOD-slim synonym: "HyTyr" EXACT PSI-MOD-label [] xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00708 name: sulfur oxygenated L-cysteine def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of L-cysteine residue without removing hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "SOxyCys" EXACT PSI-MOD-label [] xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00680 ! sulfur oxygenated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00709 name: sulfur oxygenated L-methionine def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of L-methionine residue without removing hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "SOxyMet" EXACT PSI-MOD-label [] xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00680 ! sulfur oxygenated residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00710 name: protonated-dimethylated residue def: "A protein modification that effectively adds a proton and replaces two hydrogen atoms with two methyl groups." [PubMed:18688235] comment: For N-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts for both protonation and dimethylation. The alternative Me2Res process accounts only for dimethylation and not protonation. subset: PSI-MOD-slim synonym: "Me2+Res" EXACT PSI-MOD-label [] is_a: MOD:00429 ! dimethylated residue [Term] id: MOD:00711 name: trimethylated protonated-residue def: "A protein modification that effectively replaces three hydrogen atoms with three methyl groups, after a proton has been added to form an aminium group." [PubMed:18688235] comment: For amino acids residues, amine trimethylation can effectively only be accomplished with a protonated primary amino group. This process accounts for both protonation and trimethylation. The alternative Me3Res process accounts only for trimethylation and not protonation. subset: PSI-MOD-slim synonym: "Me3+Res" EXACT PSI-MOD-label [] xref: DiffAvg: "43.09" xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0" xref: DiffMono: "43.054227" xref: FormalCharge: "1+" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00430 ! trimethylated residue [Term] id: MOD:00712 name: methylated proline def: "A protein modification that effectively converts an L-proline residue to a methylated proline, such as N,N-dimethylproline." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MePro" EXACT PSI-MOD-label [] xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:00713 name: methylated glutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to a methylated glutamic acid, such as L-glutamate 5-methyl ester." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeGlu" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00714 name: methylated glycine def: "A protein modification that effectively converts a glycine residue to a methylated glycine, such as N-methylglycine." [PubMed:18688235] synonym: "MeGly" EXACT PSI-MOD-label [] xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:00715 name: methylated isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to a methylated isoleucine residue, such as N-methyl-L-isoleucine." [PubMed:18688235] synonym: "MeIle" EXACT PSI-MOD-label [] xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00910 ! modified L-isoleucine residue [Term] id: MOD:00716 name: methylated methionine def: "A protein modification that effectively converts an L-methionine residue to a methylated methionine, such as N-methyl-L-methionine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeMet" EXACT PSI-MOD-label [] xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00427 ! methylated residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00717 name: methylated phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to a methylated phenylalanine, such as N-methyl-L-phenylalanine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MePhe" EXACT PSI-MOD-label [] xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:00718 name: methylated tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to a methylated tyrosine, such as N-methyl-L-tyrosine." [PubMed:18688235] synonym: "MeTyr" EXACT PSI-MOD-label [] xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00427 ! methylated residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00719 name: L-methionine sulfoxide def: "A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues." [DeltaMass:177, OMSSA:1, PubMed:21406390, PubMed:22116028, RESID:AA0581, UniMod:35#M] comment: From DeltaMass: Average Mass: 147 Formula:C5H9O1N2S Monoisotopic Mass Change:147.035 Average Mass Change:147.195 (formula incorrect, N and O reversed) References:PE Sciex. subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic [] synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate [] synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name [] synonym: "L-methionine S-oxide" EXACT PSI-MOD-alternate [] synonym: "L-methionine sulfoxide" EXACT PSI-MOD-alternate [] synonym: "Methionyl Sulfoxide" EXACT DeltaMass-label [] synonym: "MetO" EXACT PSI-MOD-label [] synonym: "MOD_RES Methionine (R)-sulfoxide" EXACT UniProt-feature [] synonym: "Oxidation" RELATED PSI-MS-label [] synonym: "oxym" EXACT OMSSA-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 9 N 1 O 2 S 1" xref: MassAvg: "147.19" xref: MassMono: "147.035400" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00709 ! sulfur oxygenated L-methionine is_a: MOD:01854 ! sulfur monooxygenated residue [Term] id: MOD:00720 name: L-methionine (R)-sulfoxide def: "A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide R-diastereomer." [ChEBI:45764, PubMed:21406390, PubMed:22116028, PubMed:23911929, RESID:AA0581] synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic [] synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate [] synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name [] synonym: "MOD_RES Methionine (R)-sulfoxide" EXACT UniProt-feature [] synonym: "R-MetO" EXACT PSI-MOD-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 9 N 1 O 2 S 1" xref: MassAvg: "147.19" xref: MassMono: "147.035400" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00719 ! L-methionine sulfoxide [Term] id: MOD:00721 name: L-methionine (S)-sulfoxide def: "A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide S-diastereomer." [PubMed:18688235] synonym: "S-MetO" EXACT PSI-MOD-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 9 N 1 O 2 S 1" xref: MassAvg: "147.19" xref: MassMono: "147.035400" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00719 ! L-methionine sulfoxide [Term] id: MOD:00722 name: monomethylated L-glutamine def: "A protein modification that effectively replaces one hydrogen atom of an L-glutamine residue with one methyl group." [OMSSA:14, UniMod:34#Q] subset: PSI-MOD-slim synonym: "Me1Gln" EXACT PSI-MOD-label [] synonym: "methylq" EXACT OMSSA-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 6 H 10 N 2 O 2" xref: MassAvg: "142.16" xref: MassMono: "142.074228" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00659 ! methylated glutamine [Term] id: MOD:00723 name: N-acetylated L-lysine def: "A protein modification that effectively converts an L-lysine residue to either N2-acetyl-L-lysine, or N6-acetyl-L-lysine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NAcLys" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 8 H 15 N 2 O 2" xref: MassAvg: "171.22" xref: MassMono: "171.113353" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00408 ! N-acetylated residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00724 name: N-methylated L-histidine def: "A protein modification that effectively replaces one hydrogen atom on a nitrogen of an L-histidine residue with one methyl group." [OMSSA:74, UniMod:34#H] subset: PSI-MOD-slim synonym: "Methyl" RELATED PSI-MS-label [] synonym: "methylh" EXACT OMSSA-label [] synonym: "NMeHis" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 9 N 3 O 1" xref: MassAvg: "151.17" xref: MassMono: "151.074562" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00602 ! N-methylated residue is_a: MOD:00661 ! methylated histidine [Term] id: MOD:00725 name: complex glycosylation def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group linked through a glycosidic bond." [PubMed:18688235] is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00726 name: glucosylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a glucose group through a glycosidic bond." [PubMed:18688235] synonym: "Glc" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 O 5" xref: DiffMono: "162.052823" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00727 name: mannosylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a mannose group through a glycosidic bond," [PubMed:18688235] synonym: "Man" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 O 5" xref: DiffMono: "162.052823" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00728 name: galactosylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a galactose group through a glycosidic bond." [PubMed:18688235] synonym: "Gal" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 O 5" xref: DiffMono: "162.052823" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00729 name: pentosylated residue def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a pentose sugar group through a glycosidic bond" [DeltaMass:172] comment: for Pentoses DeltaMass gives mass 132, for Pentosyl DeltaMass gives formula C 6 H 10 N4 with mass 146 synonym: "Pent" EXACT PSI-MOD-label [] synonym: "Pentoses (Ara, Rib, Xyl)" EXACT DeltaMass-label [] synonym: "Pentosyl" EXACT DeltaMass-label [] xref: DiffAvg: "132.12" xref: DiffFormula: "C 5 H 8 O 4" xref: DiffMono: "132.042259" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00730 name: arabinosylated def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a arabinose sugar group through a glycosidic bond" [PubMed:18688235] synonym: "Ara" EXACT PSI-MOD-label [] xref: DiffAvg: "132.12" xref: DiffFormula: "C 5 H 8 O 4" xref: DiffMono: "132.042259" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00729 ! pentosylated residue [Term] id: MOD:00731 name: ribosylated def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a ribose sugar group through a glycosidic bond" [PubMed:18688235] synonym: "Rib" EXACT PSI-MOD-label [] xref: DiffAvg: "132.12" xref: DiffFormula: "C 5 H 8 O 4" xref: DiffMono: "132.042259" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00729 ! pentosylated residue [Term] id: MOD:00732 name: xylosylated def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a xylose sugar group through a glycosidic bond" [PubMed:18688235] synonym: "Xyl" EXACT PSI-MOD-label [] xref: DiffAvg: "132.12" xref: DiffFormula: "C 5 H 8 O 4" xref: DiffMono: "132.042259" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00729 ! pentosylated residue [Term] id: MOD:00733 name: N-acetylaminoglucosylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylglucosamine group through a glycosidic bond." [PubMed:18688235] synonym: "GlcNAc" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00436 ! N-acetylhexosaminylated [Term] id: MOD:00734 name: N-acetylaminogalactosylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylgalactosamine group through a glycosidic bond." [DeltaMass:247] comment: From DeltaMass: Average Mass: 203 Formula:C8H13O5N1 Monoisotopic Mass Change:203.079 Average Mass Change:203.196 References:PE Sciex synonym: "GalNAc" EXACT PSI-MOD-label [] synonym: "N-acetylhexosamines (GalNAc, GlcNAc)" EXACT DeltaMass-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00436 ! N-acetylhexosaminylated [Term] id: MOD:00735 name: hexosuronylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosuronic acid group through a glycosidic bond." [PubMed:18688235] synonym: "HexA" EXACT PSI-MOD-label [] xref: DiffAvg: "176.12" xref: DiffFormula: "C 6 H 8 O 6" xref: DiffMono: "176.032088" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00736 name: deoxyhexosylated def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a deoxyhexose group through a glycosidic bond" [DeltaMass:0] comment: From DeltaMass: Average Mass: 146 subset: PSI-MOD-slim synonym: "Deoxyhexoses (Fuc, Rha)" EXACT DeltaMass-label [] synonym: "dHex" EXACT PSI-MOD-label [] xref: DiffAvg: "146.14" xref: DiffFormula: "C 6 H 10 O 4" xref: DiffMono: "146.057909" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00737 name: N-acetylneuraminylated def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond." [DeltaMass:0] comment: From DeltaMass: Average Mass: 291 synonym: "N-acetylneuraminic acid (Sialic acid, NeuAc, NANA, SA)" EXACT DeltaMass-label [] synonym: "NeuNAc" EXACT PSI-MOD-label [] xref: DiffAvg: "291.26" xref: DiffFormula: "C 11 H 17 N 1 O 8" xref: DiffMono: "291.095417" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00738 name: iron containing modified residue def: "A protein modification that effectively substitutes an iron atom or a cluster containing iron for hydrogen atoms, or that coordinates an iron ion." [PubMed:18688235] synonym: "FeRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00739 name: iron-sulfur cluster containing modification def: "A protein modification that effectively substitutes a cluster of iron and sulfur atoms for hydrogen atoms." [PubMed:18688235] synonym: "FeSRes" EXACT PSI-MOD-label [] is_a: MOD:00738 ! iron containing modified residue is_a: MOD:00860 ! sulfur containing modified residue [Term] id: MOD:00740 name: manganese containing modified residue def: "A protein modification that effectively substitutes a manganese atom or a cluster containing manganese for hydrogen atoms, or that coordinates a manganese ion." [PubMed:18688235] synonym: "MnRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00741 name: nickel containing modified residue def: "A protein modification that effectively substitutes a nickel atom or a cluster containing nickel for hydrogen atoms, or that coordinates a nickel ion." [PubMed:18688235] synonym: "NiRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00742 name: copper containing modified residue def: "A protein modification that effectively substitutes a copper atom or a cluster containing copper for hydrogen atoms, or that coordinates a copper ion." [PubMed:18688235] synonym: "CuRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00743 name: molybdenum containing modified residue def: "A protein modification that effectively substitutes a molybdenum atom or a cluster containing molybdenum for hydrogen atoms, or that coordinates a molybdenum ion." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MoRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00744 name: molybdenum pterin containing modification def: "A protein modification containing a molybdenum atom in a pterin ring system." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MoPterRes" EXACT PSI-MOD-label [] is_a: MOD:00743 ! molybdenum containing modified residue is_a: MOD:00748 ! pterin modified residue [Term] id: MOD:00745 name: selenium containing residue def: "A protein modification that effectively substitutes a selenium atom or a cluster containing selenium for hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "SeRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00746 name: tungsten containing modified residue def: "A protein modification that effectively substitutes a tungsten atom or a cluster containing tungsten for hydrogen atoms, or that coordinates a tungsten ion." [PubMed:18688235] synonym: "WRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00747 name: sodium containing modified residue def: "A protein modification that effectively substitutes a sodium atom for a hydrogen atom." [PubMed:18688235] subset: PSI-MOD-slim synonym: "NaRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00748 name: pterin modified residue def: "A protein modification that effectively results from forming an adduct with a compound containing a pterin group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "PterRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00749 name: sulfur substitution for oxygen def: "A protein modification that effectively substitutes a sulfur atom for an oxygen atom." [PubMed:18688235] subset: PSI-MOD-slim synonym: "S(O)Res" EXACT PSI-MOD-label [] is_a: MOD:00860 ! sulfur containing modified residue [Term] id: MOD:00750 name: deoxyribonucleic acid linked residue def: "A protein modification that effectively crosslinks an amino acid residue and the 3'- or 5'-end of DNA through a phosphodiester bond." [PubMed:18688235] synonym: "DNARes" EXACT PSI-MOD-label [] is_a: MOD:00701 ! nucleotide or nucleic acid modified residue [Term] id: MOD:00751 name: ribonucleic acid linked residue def: "a protein modification" [PubMed:18688235] synonym: "RNARes" EXACT PSI-MOD-label [] is_a: MOD:00701 ! nucleotide or nucleic acid modified residue [Term] id: MOD:00752 name: adenosine diphosphoribosyl (ADP-ribosyl) modified residue def: "A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond." [DeltaMass:0] comment: From DeltaMass: Average Mass: 541. subset: PSI-MOD-slim synonym: "ADP-rybosylation (from NAD)" EXACT DeltaMass-label [] synonym: "ADPRibRes" EXACT PSI-MOD-label [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00701 ! nucleotide or nucleic acid modified residue [Term] id: MOD:00753 name: chlorinated residue def: "A protein modification that effectively substitutes a chlorine atom for a hydrogen atom." [PubMed:18688235] synonym: "ClRes" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue [Term] id: MOD:00754 name: brominated residue def: "A protein modification that effectively substitutes a bromine atom for a hydrogen atom." [PubMed:18688235] synonym: "BrRes" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue [Term] id: MOD:00755 name: iodinated residue def: "A protein modification that effectively substitutes an iodine atom of a residue for a hydrogen atom." [PubMed:18688235] subset: PSI-MOD-slim synonym: "IRes" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue [Term] id: MOD:00756 name: 4-hydroxy-D-valine def: "A protein modification that effectively converts an L-valine residue to 4-hydroxy-D-valine." [PubMed:15853325, RESID:AA0388] synonym: "(2R,3Xi)-2-amino-4-hydroxy-3-methylbutanoic acid" EXACT RESID-systematic [] synonym: "4-hydroxy-D-valine" EXACT RESID-name [] synonym: "D-4HyVal" EXACT PSI-MOD-label [] synonym: "D-gamma-hydroxyvaline" EXACT RESID-alternate [] synonym: "MOD_RES D-4-hydroxyvaline" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 9 N 1 O 2" xref: MassAvg: "115.13" xref: MassMono: "115.063329" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00664 ! stereoisomerized residue [Term] id: MOD:00757 name: O4-galactosyl-L-hydroxyproline def: "A protein modification that effectively converts an L-proline residue to O4-galactosyl-L-hydroxyproline." [RESID:AA0389] comment: secondary to RESID:AA0030 synonym: "(2S,4R)-4-(beta-D-galactopyranosyloxy)pyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "4-(beta-D-galactopyranosyloxy)proline" EXACT RESID-alternate [] synonym: "4-(galactosyloxy)proline" EXACT RESID-alternate [] synonym: "beta-galactopyranosyl-4-hydroxyproline" EXACT RESID-alternate [] synonym: "O4-galactosyl-L-hydroxyproline" EXACT RESID-name [] synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate [] xref: DiffAvg: "178.14" xref: DiffFormula: "C 6 H 10 N 0 O 6" xref: DiffMono: "178.047738" xref: Formula: "C 11 H 17 N 1 O 7" xref: MassAvg: "275.26" xref: MassMono: "275.100502" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:00758 name: O4-(N-acetylamino)glucosyl-L-hydroxyproline def: "A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)glucosyl-L-hydroxyproline." [PubMed:15238247, PubMed:9660787, RESID:AA0390] comment: secondary to RESID:AA0030 synonym: "(2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-glucopyranosyloxy]pyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "4-(N-acetylglucosaminyloxy)proline" EXACT RESID-alternate [] synonym: "4-[(2-N-acetylamino)-alpha-D-glucopyranosyl]oxyproline" EXACT RESID-alternate [] synonym: "alpha-2-(N-acetylamino)glucopyranosyl-4-hydroxyproline" EXACT RESID-alternate [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "O4-(N-acetylamino)glucosyl-L-hydroxyproline" EXACT RESID-name [] synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate [] synonym: "O4GlcNAcHyPro" EXACT PSI-MOD-label [] xref: DiffAvg: "219.19" xref: DiffFormula: "C 8 H 13 N 1 O 6" xref: DiffMono: "219.074287" xref: Formula: "C 13 H 20 N 2 O 7" xref: MassAvg: "316.31" xref: MassMono: "316.127051" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00448 ! N-acetylaminoglucosylated residue is_a: MOD:01677 ! O4-(N-acetylamino)hexosyl-L-hydroxyproline [Term] id: MOD:00759 name: fucosylated biantennary (-1 galactose) def: "modification from UniMod N-linked glycosylation" [UniMod:307] synonym: "dHex(1)Hex(4)HexNAc(4)" RELATED PSI-MS-label [] synonym: "Fucosylated biantennary (-1 galactose)" RELATED UniMod-description [] xref: DiffAvg: "1607.48" xref: DiffFormula: "C 62 H 102 N 4 O 44" xref: DiffMono: "1606.586693" xref: Formula: "C 66 H 108 N 6 O 46" xref: MassAvg: "1721.59" xref: MassMono: "1720.629620" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00760 name: biantennary def: "modification from UniMod N-linked glycosylation - missing ref" [UniMod:311] synonym: "Biantennary" RELATED UniMod-description [] synonym: "Hex(5)HexNAc(4)" RELATED PSI-MS-label [] xref: DiffAvg: "1623.48" xref: DiffFormula: "C 62 H 102 N 4 O 45" xref: DiffMono: "1622.581607" xref: Formula: "C 66 H 108 N 6 O 47" xref: MassAvg: "1737.59" xref: MassMono: "1736.624535" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00761 name: monohexosylated (Hex1) def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with one hexose sugar group through a glycosidic bond." [PubMed:18688235] synonym: "Hex1" EXACT PSI-MOD-alternate [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 O 5" xref: DiffMono: "162.052823" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00434 ! hexosylated residue [Term] id: MOD:00762 name: biantennary (-2 galactose) def: "modification from UniMod N-linked glycosylation - missing ref" [UniMod:309] synonym: "Biantennary (-2 galactose)" RELATED UniMod-description [] synonym: "Hex(3)HexNAc(4)" RELATED PSI-MS-label [] xref: DiffAvg: "1299.20" xref: DiffFormula: "C 50 H 82 N 4 O 35" xref: DiffMono: "1298.475960" xref: Formula: "C 54 H 88 N 6 O 37" xref: MassAvg: "1413.30" xref: MassMono: "1412.518888" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00763 name: biantennary (-1 galactose) def: "modification from UniMod N-linked glycosylation - missing ref" [UniMod:310] synonym: "Biantennary (-1 galactose)" RELATED UniMod-description [] synonym: "Hex(4)HexNAc(4)" RELATED PSI-MS-label [] xref: DiffAvg: "1461.34" xref: DiffFormula: "C 56 H 92 N 4 O 40" xref: DiffMono: "1460.528784" xref: Formula: "C 60 H 98 N 6 O 42" xref: MassAvg: "1575.44" xref: MassMono: "1574.571711" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:00764 name: glycoconjugated residue def: "A protein modification that effectively results from forming an adduct with a carbohydrate-like group either through enzymatic formation of a glycosidic bond, or through non-enzymatic glycation formation of a Schiff-base or an Amadori ketosamine residue adduct." [PubMed:18688235, PubMed:3743566] subset: PSI-MOD-slim is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00765 name: cysteinylation (disulfide with free L-cysteine) def: "A protein modification that effectively converts an L-cysteine residue to S-(L-cysteinyl)-L-cysteine, forming a disulfide bond with free cysteine." [DeltaMass:260, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025#CYS1, UniMod:312] comment: This entry is for formation of a disulfide bond between a peptide cysteine and a free cysteine. For the cystine cross-link, see MOD:00234. From DeltaMass: (name misspelled and formula incorrect, N and O reversed) Formula: C6H10O2N3S2 Monoisotopic Mass Change: 222.013 Average Mass Change: 222.283 subset: PSI-MOD-slim synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer [] synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate [] synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate [] synonym: "3,3'-dithiodialanine" EXACT RESID-alternate [] synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate [] synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate [] synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate [] synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate [] synonym: "Cysteinylation" EXACT DeltaMass-label [] synonym: "dicysteine" EXACT RESID-alternate [] synonym: "L-cystine" EXACT RESID-name [] synonym: "MOD_RES S-cysteinyl cysteine" EXACT UniProt-feature [] synonym: "S-cystenyl cystenyl" EXACT DeltaMass-label [] synonym: "SCysCys" EXACT PSI-MOD-label [] xref: DiffAvg: "119.14" xref: DiffFormula: "C 3 H 5 N 1 O 2 S 1" xref: DiffMono: "119.004099" xref: Formula: "C 6 H 10 N 2 O 3 S 2" xref: MassAvg: "222.28" xref: MassMono: "222.013284" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01862 ! disulfide conjugated residue [Term] id: MOD:00766 name: C terminal -K from HC of MAb def: "modification from UniMod Post-translational - C-terminal loss of lysine" [PubMed:16078144, UniMod:313] synonym: "Loss of C-terminal K from Heavy Chain of MAb" RELATED UniMod-description [] synonym: "Lys-loss" RELATED PSI-MS-label [] xref: DiffAvg: "-128.18" xref: DiffFormula: "C -6 H -12 N -2 O -1" xref: DiffMono: "-128.094963" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: TermSpec: "C-term" is_a: MOD:00003 ! UniMod [Term] id: MOD:00767 name: glycated residue def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein amino group to form a Schiff-base or an Amadori ketosamine residue adduct." [PubMed:18688235] xref: Source: "artifact" is_a: MOD:00764 ! glycoconjugated residue [Term] id: MOD:00768 name: methionine oxidation with neutral loss of 80 Da def: "Oxidation of methionine to methionine sulfone with neutral loss of CH3SO2H." [PubMed:18688235, PubMed:9004526] comment: Originally created from UniMod:508 that was later deleted. xref: DiffAvg: "-80.10" xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1" xref: DiffMono: "-79.993200" xref: Formula: "C 4 H 5 N 1 O 1 S 0" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00431 ! modified residue with a secondary neutral loss [Term] id: MOD:00769 name: residues isobaric at 71.0-71.1 Da def: "Natural or modified residues with a mass of 71.0-71.1 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da [Term] id: MOD:00770 name: residues isobaric at a resolution below 0.01 Da def: "Natural or modified residues that are isobaric at a resolution below 0.01 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da [Term] id: MOD:00771 name: residues isobaric at 166.98-167.00 Da def: "Natural or modified residues with a mass of 166.98-167.00 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da [Term] id: MOD:00772 name: vanadium containing modified residue def: "A protein modification that effectively substitutes a vanadium atom or a cluster containing vanadium for hydrogen atoms, or that coordinates a vanadium ion." [PubMed:18688235] synonym: "VRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00773 name: residues isobaric at 181.00-181.02 Da def: "Natural or modified residues with a mass of 181.00-181.02 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da [Term] id: MOD:00774 name: residues isobaric at 243.02-243.03 Da def: "Natural or modified residues with a mass of 243.02-243.03 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da [Term] id: MOD:00775 name: L-asparagine (His) def: "An artifactual protein modification that converts an L-histidine residue to L-asparagine by oxidative degradation." [OMSSA:54, PubMed:9252331, UniMod:348] synonym: "His->Asn" RELATED PSI-MS-label [] synonym: "his2asnh" EXACT OMSSA-label [] synonym: "histidine oxidation to aspargine" RELATED UniMod-description [] xref: DiffAvg: "-23.04" xref: DiffFormula: "C -2 H -1 N -1 O 1" xref: DiffMono: "-23.015984" xref: Formula: "C 4 H 6 N 2 O 2" xref: MassAvg: "114.10" xref: MassMono: "114.042927" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00012 ! L-asparagine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00776 name: L-aspartic acid (His) def: "An artifactual protein modification that converts an L-histidine residue to L-aspartic acid by oxidative degradation." [OMSSA:55, PubMed:9252331, UniMod:349] comment: From OMSSA: desc="oxidation of H to D" monomass= -23.015984 (this is the same mass difference as OMSSA:54, his2asnh) [JSG]. synonym: "His->Asp" RELATED PSI-MS-label [] synonym: "his2asph" EXACT OMSSA-label [] synonym: "histidine oxidation to aspartic acid" RELATED UniMod-description [] xref: DiffAvg: "-22.05" xref: DiffFormula: "C -2 H -2 N -2 O 2" xref: DiffMono: "-22.031969" xref: Formula: "C 4 H 5 N 1 O 3" xref: MassAvg: "115.09" xref: MassMono: "115.026943" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00013 ! L-aspartic acid residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00777 name: residues isobaric at 182.96-182.98 Da def: "Natural or modified residues with a mass of 182.96-182.98 Da." [PubMed:18688235] is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da is_a: MOD:00778 ! residues isobaric at 182.9-183.0 Da [Term] id: MOD:00778 name: residues isobaric at 182.9-183.0 Da def: "Natural or modified residues with a mass of 182.9-183.0 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da [Term] id: MOD:00779 name: lysine oxidation to aminoadipic semialdehyde def: "OBSOLETE because redundant with MOD:00130. Remap to MOD:00130." [DeltaMass:352, PubMed:11332453, PubMed:358196, PubMed:5337886, PubMed:5529814, UniMod:352] comment: From DeltaMass: Average Mass: -1 Average Mass Change:-1 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. synonym: "Oxidation of lysine (to aminoadipic semialdehyde)" EXACT DeltaMass-label [] xref: DiffAvg: "-1.03" xref: DiffFormula: "H -3 N -1 O 1" xref: DiffMono: "-1.031634" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00780 name: N-acetyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N-acetyl-L-asparagine." [PubMed:18688235] comment: This modification has not been observed to occur naturally. synonym: "AcAsn" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 6 H 8 N 2 O 3" xref: MassAvg: "156.14" xref: MassMono: "156.053492" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00781 name: N2-acetyl-L-histidine def: "A protein modification that effectively converts an L-histidine residue to N2-acetyl-L-histidine." [PubMed:18688235] comment: This modification has not been observed to occur naturally. synonym: "AcHis" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 8 H 9 N 3 O 2" xref: MassAvg: "179.18" xref: MassMono: "179.069477" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00782 name: N-acetyl-L-leucine def: "A protein modification that effectively converts an L-leucine residue to N-acetyl-L-leucine." [PubMed:18688235] comment: This modification has not been observed to occur naturally. synonym: "AcLeu" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 8 H 14 N 1 O 2" xref: MassAvg: "156.20" xref: MassMono: "156.102454" xref: Origin: "L" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00911 ! modified L-leucine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00783 name: dimethylated L-arginine def: "A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two methyl groups." [OMSSA:37, UniMod:36#R] subset: PSI-MOD-slim synonym: "Dimethyl" RELATED PSI-MS-label [] synonym: "dimethylr" EXACT OMSSA-label [] synonym: "NNMe2Arg" EXACT PSI-MOD-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 16 N 4 O 1" xref: MassAvg: "184.24" xref: MassMono: "184.132411" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00429 ! dimethylated residue is_a: MOD:00658 ! methylated arginine [Term] id: MOD:00784 name: N-acetyl-L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to N-acetyl-L-phenylalanine." [PubMed:18688235] comment: This modification has not been observed to occur naturally. synonym: "AcPhe" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 11 H 11 N 1 O 2" xref: MassAvg: "189.21" xref: MassMono: "189.078979" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00785 name: N2-acetyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to N2-acetyl-L-tryptophan." [PubMed:18688235] comment: This modification has not been observed to occur naturally. synonym: "AcTrp" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 13 H 12 N 2 O 2" xref: MassAvg: "228.25" xref: MassMono: "228.089878" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00918 ! modified L-tryptophan residue is_a: MOD:01458 ! alpha-amino acetylated residue [Term] id: MOD:00786 name: deuterium substituted residue def: "A protein modification that effectively substitutes one or more (2)H deuterium atoms for (1)H protium atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "D(H)Res" EXACT PSI-MOD-label [] is_a: MOD:00839 ! (2)H deuterium labeled residue [Term] id: MOD:00787 name: diisopropylphosphoserine def: "modification from UniMod - label for the active site serine of the serine esterase/protease family also shown to label tyrosine in serum albumin" [UniMod:362] synonym: "Diisopropylphosphate" RELATED UniMod-interim [] synonym: "O-Diisopropylphosphorylation" RELATED UniMod-description [] xref: DiffAvg: "164.14" xref: DiffFormula: "C 6 H 13 O 3 P 1" xref: DiffMono: "164.060231" xref: Formula: "C 9 H 18 N 1 O 5 P 1" xref: MassAvg: "251.22" xref: MassMono: "251.092259" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00788 name: isopropylphosphotyrosine def: "modification from UniMod" [UniMod:363] synonym: "Isopropylphospho" RELATED UniMod-interim [] synonym: "O-Isopropylphosphorylation" RELATED UniMod-description [] xref: DiffAvg: "122.06" xref: DiffFormula: "C 3 H 7 O 3 P 1" xref: DiffMono: "122.013281" xref: Formula: "C 12 H 16 N 1 O 5 P 1" xref: MassAvg: "285.24" xref: MassMono: "285.076609" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00789 name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form def: "modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied." [PubMed:15602776, UniMod:364, URL:http\://www.serva.de/products/sheets/39230-E.pdf] synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form" RELATED UniMod-description [] synonym: "ICPL:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "111.04" xref: DiffFormula: "(13)C 6 H 3 N 1 O 1" xref: DiffMono: "111.041593" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00790 name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form def: "modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied." [PubMed:15602776, UniMod:365, URL:http\://www.serva.de/products/sheets/39230-E.pdf] synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form" RELATED UniMod-description [] synonym: "ICPL" RELATED PSI-MS-label [] xref: DiffAvg: "105.02" xref: DiffFormula: "(12)C 6 H 3 N 1 O 1" xref: DiffMono: "105.021464" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00791 name: 1x(18)O labeled deamidated L-glutamine def: "A protein modification that effectively converts an L-glutamine residue to L-glutamic acid with one (18)O." [PubMed:8382902, UniMod:366#Q] subset: PSI-MOD-slim synonym: "Deamidated:18O(1)" RELATED PSI-MS-label [] synonym: "Deamidation in presence of O18" RELATED UniMod-description [] xref: DiffAvg: "2.99" xref: DiffFormula: "H -1 N -1 (18)O 1" xref: DiffMono: "2.988262" xref: Formula: "C 5 H 7 N 1 (16)O 2 (18)O 1" xref: MassAvg: "131.05" xref: MassMono: "131.046839" xref: Origin: "Q" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00685 ! deamidated L-glutamine is_a: MOD:00852 ! 1x(18)O labeled deamidated residue [Term] id: MOD:00792 name: deuterium monosubstituted residue def: "A protein modification that effectively substitutes one (2)H deuterium atom for one (1)H protium atom." [PubMed:18688235] subset: PSI-MOD-slim synonym: "D(H)1Res" EXACT PSI-MOD-label [] is_a: MOD:00786 ! deuterium substituted residue [Term] id: MOD:00793 name: dehydroalanine (Cys) def: "A protein modification that effectively converts an L-cysteine residue to dehydroalanine." [ChEBI:17123, DeltaMass:8, PubMed:10220322, PubMed:11212008, PubMed:1547888, PubMed:15799070, PubMed:1815586, PubMed:20805503, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181#CYS, UniMod:368] comment: From DeltaMass: In an attempt to clarfiy the difference between the modification of cysteine to lanthionine and cysteine to dehydroalanine, the following contributions from the ABRF email forum are presented:Structurally speaking lanthionine is like cystine but lacks one S atom. I imagine one can think of it as a condensation of cysteine and dehydroalanine but I do not know how it is made biologically. Dehydroalanine could be derived from either serine or cysteine. If I recall Biochem 101 correctly lanthionine was first found in wool.-Lowell Ericsson (ERICSSONLH@U.WASHINGTON.EDU)As far as I know, the structure of lanthionine is two Ala's joined by a single sulphur with the loss of two hydrogens from the methyl group of the Ala.Stephen Bayne (sbay@novo.dk)Regarding the structure of lanthionine and dehydroalanine: dehydroalanine is formed by the loss of one sulfur atom and two hydrogen atoms from ONE cysteine residue. lanthionine is formed from TWO cysteines, is a thioether, and contains one sulfur atom less than the amino acid cystine. Dan McCormick (MCCORMICK@rcf.mayo.edu) [DeltaMass]. Most bacterially produced lanthionine crosslinks are made by dehydration of L-serine to dehydroalanine, and then reaction with L-cysteine so as to produce chiral inversion at the alpha-carbon of the original L-serine; the lanthionine is a meso-diastereomer with L-configuration of the original cysteine alpha-carbon and D-configuration of the original L-serine alpha-carbon. In cypemycin dehydroalanine has been shown to be produced by loss of hydrogen sulfide from cysteine. Beta-elimination of hydrogen sulfide does occur during treatment with performic acid [JSG]. subset: PSI-MOD-slim synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] synonym: "anhydroserine" EXACT RESID-alternate [] synonym: "Cys->Dha" RELATED PSI-MS-label [] synonym: "dehydroalanine" EXACT RESID-name [] synonym: "Dehydroalanine (from Cysteine)" EXACT DeltaMass-label [] synonym: "Dehydroalanine (from Cysteine)" RELATED UniMod-description [] synonym: "Dha" EXACT RESID-alternate [] synonym: "dHAla(Cys)" EXACT PSI-MOD-label [] synonym: "MOD_RES 2,3-didehydroalanine (Cys)" EXACT UniProt-feature [] xref: DiffAvg: "-34.08" xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1" xref: DiffMono: "-33.987721" xref: Formula: "C 3 H 3 N 1 O 1" xref: MassAvg: "69.06" xref: MassMono: "69.021464" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01168 ! dehydroalanine [Term] id: MOD:00794 name: pyrrolidone from proline def: "OBSOLETE because redundant and identical to MOD:00477. Remap to MOD:00477." [PubMed:9252331, UniMod:369] comment: This UniMod entry appears to have come from the same description in PubMed:9252331 as UniMod:360. This entry was not annotated as being approved. Neither difference formula corresponds to the result described in the original citation PubMed:2161657. synonym: "Pro->Pyrrolidone" RELATED UniMod-interim [] synonym: "Pyrrolidone from Proline" RELATED UniMod-description [] xref: DiffAvg: "-28.01" xref: DiffFormula: "C -1 O -1" xref: DiffMono: "-27.994915" xref: Formula: "C 4 H 7 N 1 O 0" xref: MassAvg: "69.11" xref: MassMono: "69.057849" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00795 name: Michael addition of hydroxymethylvinyl ketone to cysteine def: "modification from UniMod" [PubMed:11743741, UniMod:371] synonym: "HMVK" RELATED PSI-MS-label [] synonym: "Michael addition of hydroxymethylvinyl ketone to cysteine" RELATED UniMod-description [] xref: DiffAvg: "86.09" xref: DiffFormula: "C 4 H 6 O 2" xref: DiffMono: "86.036779" xref: Formula: "C 7 H 11 N 1 O 3 S 1" xref: MassAvg: "189.23" xref: MassMono: "189.045964" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00796 name: L-ornithine (Arg) def: "A protein modification that effectively converts an L-arginine residue to L-ornithine." [DeltaMass:129, OMSSA:163, PubMed:15489230, UniMod:372] subset: PSI-MOD-slim synonym: "Arg->Orn" RELATED PSI-MS-label [] synonym: "arg2orn" EXACT OMSSA-label [] synonym: "Ornithine (from Arginine)" EXACT DeltaMass-label [] synonym: "Ornithine from Arginine" RELATED UniMod-description [] synonym: "Ornithyl" EXACT DeltaMass-label [] xref: DiffAvg: "-42.04" xref: DiffFormula: "C -1 H -2 N -2" xref: DiffMono: "-42.021798" xref: Formula: "C 5 H 10 N 2 O 1" xref: MassAvg: "114.15" xref: MassMono: "114.079313" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00797 name: 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal def: "a protein modification that effectively converts an L-cysteine residue to the PEP adduct, 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal" [PubMed:4696757, PubMed:7999765, PubMed:8664284, RESID:AA0391] synonym: "(2R)-2-amino-3-[1-carboxy-1-(phosphonooxy)ethyl]sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid" EXACT RESID-alternate [] synonym: "2-([(2R)-2-azanyl-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid" EXACT RESID-alternate [] synonym: "2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal" EXACT RESID-name [] synonym: "cysteinyl pyruvate O-phosphothioketal" EXACT RESID-alternate [] synonym: "MOD_RES 2-(S-cysteinyl)pyruvic acid O-phosphothioketal" EXACT UniProt-feature [] synonym: "phosphoenolpyruvate cysteine adduct" EXACT RESID-alternate [] synonym: "phospholactoyl cysteine adduct" EXACT RESID-alternate [] synonym: "S-[1-carboxy-1-(phosphonooxy)ethyl]cysteine" EXACT RESID-alternate [] synonym: "SPEPCys" EXACT PSI-MOD-label [] xref: DiffAvg: "168.04" xref: DiffFormula: "C 3 H 5 N 0 O 6 P 1 S 0" xref: DiffMono: "167.982375" xref: Formula: "C 6 H 10 N 1 O 7 P 1 S 1" xref: MassAvg: "271.18" xref: MassMono: "270.991559" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00798 name: half cystine def: "A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed." [PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, UniMod:374] synonym: "Dehydro" RELATED PSI-MS-label [] synonym: "Half of a disulfide bridge" RELATED UniMod-description [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0 S 0" xref: DiffMono: "-1.007825" xref: Formula: "C 3 H 4 N 1 O 1 S 1" xref: MassAvg: "102.13" xref: MassMono: "102.001360" xref: Origin: "C" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00799 name: S-galactosyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-galactosyl-L-cysteine." [PubMed:11945907, RESID:AA0392] comment: The reported peptide has not been isolated or characterized in subsequent work, and the peptide sequence has not been found in the human proteome. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "(2R)-2-amino-3-(D-galactopyranosylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "S-(beta-D-galactopyranosyl)cysteine" EXACT RESID-alternate [] synonym: "S-galactosyl-L-cysteine" EXACT RESID-name [] synonym: "S-glycosyl-cysteine" EXACT RESID-alternate [] synonym: "SGalCys" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5 S 0" xref: DiffMono: "162.052823" xref: Formula: "C 9 H 15 N 1 O 6 S 1" xref: MassAvg: "265.28" xref: MassMono: "265.062008" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00426 ! S-glycosylated residue is_a: MOD:00476 ! galactosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00800 name: L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-vanadium seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide." [PubMed:2345152, RESID:AA0393] comment: Cross-link 2; incidental to RESID:AA0300. synonym: "CysHis-[V7Fe9S]" EXACT PSI-MOD-label [] synonym: "L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide carbide" EXACT RESID-name [] synonym: "nitrogenase iron-vanadium cofactor" EXACT RESID-alternate [] xref: DiffAvg: "932.51" xref: DiffFormula: "C 7 Fe 7 H 6 N 0 O 7 S 9 V 1" xref: DiffMono: "932.248513" xref: Formula: "C 16 Fe 7 H 18 N 4 O 9 S 10 V 1" xref: MassAvg: "1172.80" xref: MassMono: "1172.316610" xref: Origin: "C, H" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00772 ! vanadium containing modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00801 name: L-cysteinyl-L-histidino-homocitryl octairon nonasulfide def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and an eight-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl octairon nonasulfide." [PubMed:8392330, RESID:AA0394] comment: Cross-link 2; incidental to RESID:AA0300. synonym: "CysHis-[8Fe9S]" EXACT PSI-MOD-label [] synonym: "L-cysteinyl-L-histidino-homocitryl octairon nonasulfide carbide" EXACT RESID-name [] synonym: "nitrogenase iron-iron cofactor" EXACT RESID-alternate [] xref: DiffAvg: "937.42" xref: DiffFormula: "C 7 Fe 8 H 6 N 0 O 7 S 9" xref: DiffMono: "937.240588" xref: FormalCharge: "2-" xref: Formula: "C 16 Fe 8 H 18 N 4 O 9 S 10" xref: MassAvg: "1177.70" xref: MassMono: "1177.308685" xref: Origin: "C, H" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00802 name: L-histidino vanadium tetraoxide def: "a protein modification that effectively converts an L-histidine residue to L-histidino vanadium tetraoxide" [PubMed:10543953, PubMed:16494433, PubMed:8552646, RESID:AA0395] synonym: "(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (dihydroxy)dioxovanadium" EXACT RESID-alternate [] synonym: "1'-vanadato-L-histidine" EXACT RESID-alternate [] synonym: "bromoperoxidase vanadium cofactor" EXACT RESID-alternate [] synonym: "chloroperoxidase vanadium cofactor" EXACT RESID-alternate [] synonym: "dihydrogen (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (tetraoxido)vanadate" EXACT RESID-systematic [] synonym: "haloperoxidase vanadium cofactor" EXACT RESID-alternate [] synonym: "histidine-1-vanadate" EXACT RESID-alternate [] synonym: "histidine-N(epsilon)-vanadate" EXACT RESID-alternate [] synonym: "histidine-N1'-vanadate" EXACT RESID-alternate [] synonym: "L-histidino vanadium tetraoxide" EXACT RESID-name [] synonym: "N(tau)-vanadatohistidine" EXACT RESID-alternate [] synonym: "NtauH2VO4His" EXACT PSI-MOD-label [] synonym: "tele-vanadatohistidine" EXACT RESID-alternate [] xref: DiffAvg: "116.95" xref: DiffFormula: "C 0 H 2 N 0 O 4 V 1" xref: DiffMono: "116.939268" xref: Formula: "C 6 H 9 N 3 O 5 V 1" xref: MassAvg: "254.10" xref: MassMono: "253.998180" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00772 ! vanadium containing modified residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00803 name: 3-(S-L-cysteinyl)-L-tyrosine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine." [PubMed:15342250, RESID:AA0396] comment: Cross-link 2. synonym: "(2S,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(2-amino-2-carboxyethylthio)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-alternate [] synonym: "3-(L-cystein-S-yl)-L-tyrosine" EXACT RESID-name [] synonym: "CROSSLNK 3-(S-cysteinyl)-tyrosine (Cys-Tyr)" EXACT UniProt-feature [] synonym: "S-(tyros-3'-yl)cysteine" EXACT RESID-alternate [] synonym: "XLNKSCys3Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 12 H 12 N 2 O 3 S 1" xref: MassAvg: "264.30" xref: MassMono: "264.056863" xref: Origin: "C, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01993 ! beta-carbon thioether crosslinked residues [Term] id: MOD:00804 name: O-glucosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine." [PubMed:10734111, PubMed:2105311, PubMed:2511201, RESID:AA0397] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(beta-D-glucopyranosyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (Glc)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] synonym: "O-glucosyl-L-serine" EXACT RESID-name [] synonym: "O-glycosylserine" EXACT RESID-alternate [] synonym: "O3-glucosylserine" EXACT RESID-alternate [] synonym: "OGlcSer" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 9 H 15 N 1 O 7" xref: MassAvg: "249.22" xref: MassMono: "249.084852" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine is_a: MOD:00433 ! glucosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) [Term] id: MOD:00805 name: O-(N-acetylamino)glucosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminoglucosyl)-L-serine." [PubMed:3086323, PubMed:8404891, RESID:AA0398] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (GlcNAc)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] synonym: "O-(N-acetylamino)glucosyl-L-serine" EXACT RESID-name [] synonym: "O-(N-acetylglucosaminyl)serine" EXACT RESID-alternate [] synonym: "O-glycosylserine" EXACT RESID-alternate [] synonym: "O-seryl-beta-N-acetylglucosaminide" EXACT RESID-alternate [] synonym: "O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] synonym: "O3-(N-acetylglucosaminyl)serine" EXACT RESID-alternate [] synonym: "OGlcNAcSer" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 11 H 18 N 2 O 7" xref: MassAvg: "290.27" xref: MassMono: "290.111401" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00448 ! N-acetylaminoglucosylated residue is_a: MOD:01675 ! O-(N-acetylamino)hexosyl-L-serine [Term] id: MOD:00806 name: O-(N-acetylamino)glucosyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminoglucosyl)-L-threonine." [PubMed:3086323, PubMed:8404891, RESID:AA0399] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)butanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (GlcNAc)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-threonine" EXACT RESID-alternate [] synonym: "O-(N-acetylamino)glucosyl-L-threonine" EXACT RESID-name [] synonym: "O-(N-acetylglucosaminyl)-L-threonine" EXACT RESID-alternate [] synonym: "O-glycosylthreonine" EXACT RESID-alternate [] synonym: "O-threonyl-beta-N-acetylglucosaminide" EXACT RESID-alternate [] synonym: "O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-threonine" EXACT RESID-alternate [] synonym: "O3-(N-acetylglucosaminyl)threonine" EXACT RESID-alternate [] synonym: "OGlcNAcThr" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 12 H 20 N 2 O 7" xref: MassAvg: "304.30" xref: MassMono: "304.127051" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00448 ! N-acetylaminoglucosylated residue is_a: MOD:01676 ! O-(N-acetylamino)hexosyl-L-threonine [Term] id: MOD:00807 name: pyruvic acid (Ser) def: "A protein modification that effectively converts an L-serine residue to pyruvic acid." [DeltaMass:23, PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127#SER, UniMod:385#S] comment: DeltaMass gives mass 70 and difference mass -16 with no formula subset: PSI-MOD-slim synonym: "2-oxopropanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES Pyruvic acid (Ser)" EXACT UniProt-feature [] synonym: "Pyruvate" EXACT DeltaMass-label [] synonym: "pyruvic acid" EXACT RESID-name [] synonym: "Pyruvoyl- (Serine)" EXACT DeltaMass-label [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 3 H 3 O 2" xref: MassAvg: "71.06" xref: MassMono: "71.013304" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01154 ! pyruvic acid is_a: MOD:01160 ! deaminated residue [Term] id: MOD:00808 name: O-galactosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-galactosylserine." [PubMed:666730, RESID:AA0400] synonym: "(2S)-2-amino-3-(alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (Gal)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] synonym: "O-galactosyl-L-serine" EXACT RESID-name [] synonym: "O-glycosylserine" EXACT RESID-alternate [] synonym: "O3-galactosylserine" EXACT RESID-alternate [] synonym: "OGalSer" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 9 H 15 N 1 O 7" xref: MassAvg: "249.22" xref: MassMono: "249.084852" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine is_a: MOD:00476 ! galactosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) [Term] id: MOD:00809 name: O-galactosyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O3-galactosylthreonine." [PubMed:2673008, RESID:AA0401] synonym: "(2S,3R)-2-amino-3-(alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (Gal)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] synonym: "O-galactosyl-L-threonine" EXACT RESID-name [] synonym: "O-glycosylthreonine" EXACT RESID-alternate [] synonym: "O3-galactosylthreonine" EXACT RESID-alternate [] synonym: "OGalThr" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 10 H 17 N 1 O 7" xref: MassAvg: "263.25" xref: MassMono: "263.100502" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00476 ! galactosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:01348 ! O-hexosylated threonine [Term] id: MOD:00810 name: O-mannosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-mannosylserine." [PubMed:391559, RESID:AA0402] synonym: "(2S)-2-amino-3-(alpha-D-mannopyranosyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (Man)" EXACT UniProt-feature [] synonym: "O-glycosylserine" EXACT RESID-alternate [] synonym: "O-mannopyranosylserine" EXACT RESID-alternate [] synonym: "O-mannosyl-L-serine" EXACT RESID-name [] synonym: "O3-mannosylserine" EXACT RESID-alternate [] synonym: "OManSer" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 9 H 15 N 1 O 7" xref: MassAvg: "249.22" xref: MassMono: "249.084852" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine is_a: MOD:00595 ! mannosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) [Term] id: MOD:00811 name: O-mannosyl-L-threonine def: "a protein modification that effectively forms a O3-mannosylthreonine" [PubMed:391559, RESID:AA0403] synonym: "(2S,3R)-2-amino-3-(alpha-D-mannopyranosyloxy)butanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (Man)" EXACT UniProt-feature [] synonym: "O-glycosylthreonine" EXACT RESID-alternate [] synonym: "O-mannosyl-L-threonine" EXACT RESID-name [] synonym: "O3-mannosylthreonine" EXACT RESID-alternate [] synonym: "OManThr" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 10 H 17 N 1 O 7" xref: MassAvg: "263.25" xref: MassMono: "263.100502" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00595 ! mannosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:01348 ! O-hexosylated threonine [Term] id: MOD:00812 name: O-fucosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to an O-fucosylserine." [PubMed:10734111, PubMed:11067851, PubMed:11344537, PubMed:12096136, PubMed:1517205, PubMed:15189151, PubMed:1904059, PubMed:3311742, PubMed:3578767, RESID:AA0404, UniMod:295#S] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (dHex)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (Fuc)" EXACT UniProt-feature [] synonym: "dHex" RELATED PSI-MS-label [] synonym: "Fucose" RELATED UniMod-description [] synonym: "O-fucosyl-L-serine" EXACT RESID-name [] synonym: "O-glycosylserine" EXACT RESID-alternate [] synonym: "O3-fucosylserine" EXACT RESID-alternate [] synonym: "OFucSer" EXACT PSI-MOD-label [] xref: DiffAvg: "146.14" xref: DiffFormula: "C 6 H 10 N 0 O 4" xref: DiffMono: "146.057909" xref: Formula: "C 9 H 15 N 1 O 6" xref: MassAvg: "233.22" xref: MassMono: "233.089937" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine is_a: MOD:00614 ! fucosylated [Term] id: MOD:00813 name: O-fucosyl-L-threonine def: "A protein modification that effectively converts an threonine residue to an O-fucosylthreonine." [PubMed:11344537, PubMed:11857757, PubMed:15189151, PubMed:1740125, PubMed:1900431, RESID:AA0405, UniMod:295#T] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (dHex)" EXACT UniProt-feature [] synonym: "CARBOHYD O-linked (Fuc)" EXACT UniProt-feature [] synonym: "dHex" RELATED PSI-MS-label [] synonym: "Fucose" RELATED UniMod-description [] synonym: "O-fucosyl-L-threonine" EXACT RESID-name [] synonym: "O-glycosylthreonine" EXACT RESID-alternate [] synonym: "O3-fucosylthreonine" EXACT RESID-alternate [] synonym: "OFucThr" EXACT PSI-MOD-label [] xref: DiffAvg: "146.14" xref: DiffFormula: "C 6 H 10 N 0 O 4" xref: DiffMono: "146.057909" xref: Formula: "C 10 H 17 N 1 O 6" xref: MassAvg: "247.25" xref: MassMono: "247.105587" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00005 ! O-glycosyl-L-threonine is_a: MOD:00614 ! fucosylated [Term] id: MOD:00814 name: O-xylosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-xylosylserine." [PubMed:8747463, RESID:AA0406] comment: One glycosylated serine with weak electron density was modeled as O3-alpha-xylosylserine, while O3-alpha-mannosyl serine and threonine were modeled at ten other positions. The authors do not discuss this exception or provide chemical evidence for it. Since an O3-xylosyl serine modification has not been reported in any other fungal proteins, the modification is probably also an O3-alpha-mannosyl serine, see MOD:00810 [JSG]. synonym: "(2S)-2-amino-3-(alpha-D-xylopyranosyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "O-(beta-D-xylopyranosyl)-L-serine" EXACT RESID-alternate [] synonym: "O-glycosylserine" EXACT RESID-alternate [] synonym: "O-xylosyl-L-serine" EXACT RESID-name [] synonym: "O3-xylosylserine" EXACT RESID-alternate [] synonym: "OXylSer" EXACT PSI-MOD-label [] xref: DiffAvg: "132.12" xref: DiffFormula: "C 5 H 8 N 0 O 4" xref: DiffMono: "132.042259" xref: Formula: "C 8 H 13 N 1 O 6" xref: MassAvg: "219.19" xref: MassMono: "219.074287" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine [Term] id: MOD:00815 name: molybdopterin def: "OBSOLETE because redundant with MOD:00151. Remap to MOD:00151." [PubMed:14527393, PubMed:7878465, PubMed:9428520] xref: DiffAvg: "520.27" xref: DiffFormula: "C 10 H 11 Mo 1 N 5 O 8 P 1 S 2" xref: DiffMono: "521.884074" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00816 name: S-stearoyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-stearoyl-L-cysteine." [DeltaMass:0, PubMed:2371783, PubMed:3143715, PubMed:8761467, RESID:AA0407] comment: From DeltaMass: Average Mass: 266 subset: PSI-MOD-slim synonym: "(R)-2-amino-3-(octadecanoylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(octadecanoylthio)propanoic acid" EXACT RESID-alternate [] synonym: "cysteine octadecanoate thioester" EXACT RESID-alternate [] synonym: "cysteine stearate thioester" EXACT RESID-alternate [] synonym: "LIPID S-stearoyl cysteine" EXACT UniProt-feature [] synonym: "S-stearoyl-L-cysteine" EXACT RESID-name [] synonym: "SSteCys" EXACT PSI-MOD-label [] synonym: "Stearoylation" EXACT DeltaMass-label [] xref: DiffAvg: "266.47" xref: DiffFormula: "C 18 H 34 N 0 O 1 S 0" xref: DiffMono: "266.260966" xref: Formula: "C 21 H 39 N 1 O 2 S 1" xref: MassAvg: "369.61" xref: MassMono: "369.270150" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00672 ! S-acylated residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00817 name: 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan." [ChEBI:35304, PubMed:16407988, PubMed:8168130, RESID:AA0408] synonym: "(2S,3aR,8aS)-3a-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophan" EXACT RESID-alternate [] synonym: "3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan" EXACT RESID-name [] synonym: "3'Ger2'N2cycTrp" EXACT PSI-MOD-label [] synonym: "LIPID 3'-geranyl-2',N2-cyclotryptophan" EXACT UniProt-feature [] xref: DiffAvg: "136.24" xref: DiffFormula: "C 10 H 16 N 0 O 0" xref: DiffMono: "136.125201" xref: Formula: "C 21 H 26 N 2 O 1" xref: MassAvg: "322.45" xref: MassMono: "322.204513" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00601 ! cyclized residue is_a: MOD:01115 ! isoprenylated tryptophan [Term] id: MOD:00818 name: glycosylphosphatidylinositolated residue def: "A protein modification that effectively converts a residue to a glycosylphosphatidylinositolethanolamidated." [PubMed:12643538, UniMod:394#C-term] synonym: "glycosylphosphatidylinositol" RELATED UniMod-description [] synonym: "GPIanchor" RELATED UniMod-interim [] synonym: "GPIRes" EXACT PSI-MOD-label [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00764 ! glycoconjugated residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:00819 name: L-2-aminobutanoic acid (Glu) def: "A protein modification that effectively converts an L-glutamic acid residue to L-2-aminobutanoic acid." [ChEBI:35619, DeltaMass:0, PubMed:11740505, RESID:AA0409] synonym: "(S)-2-aminobutanoic acid" EXACT RESID-systematic [] synonym: "Abu" EXACT DeltaMass-label [] synonym: "Abu" EXACT PSI-MOD-label [] synonym: "alpha-amino-n-butyric acid" EXACT PSI-MOD-alternate [] synonym: "alpha-aminobutyric acid" EXACT PSI-MOD-alternate [] synonym: "butyrine" EXACT PSI-MOD-alternate [] synonym: "dCbxGlu" EXACT PSI-MOD-alternate [] synonym: "L-2-amino-n-butyric acid" EXACT RESID-alternate [] synonym: "L-2-aminobutanoic acid" EXACT RESID-name [] synonym: "L-2-aminobutyric acid" EXACT RESID-alternate [] synonym: "L-alpha-amino-n-butyric acid" EXACT RESID-alternate [] synonym: "L-alpha-aminobutyric acid" EXACT RESID-alternate [] synonym: "L-butyrine" EXACT RESID-alternate [] xref: DiffAvg: "-44.01" xref: DiffFormula: "C -1 H 0 N 0 O -2" xref: DiffMono: "-43.989829" xref: Formula: "C 4 H 7 N 1 O 1" xref: MassAvg: "85.11" xref: MassMono: "85.052764" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00820 name: 2-imino-alanine 5-imidazolinone glycine def: "A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue to form 2-imino-alanine 5-imidazolinone glycine." [PubMed:16627946, RESID:AA0410] comment: Cross-link 2; carboxamidine. synonym: "(2-ethanimidoyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic [] synonym: "2,N-didehydroalanyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "2-(1-iminoethyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate [] synonym: "2-imino-alanine 5-imidazolinone glycine" EXACT RESID-name [] synonym: "2-imino-alanyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "[2-(1-iminoethyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate [] synonym: "alanyl-5-imidazolinone glycine" EXACT RESID-alternate [] synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate [] synonym: "red fluorescent protein zRFP574 chromophore" EXACT RESID-alternate [] xref: DiffAvg: "-64.04" xref: DiffFormula: "C -1 H -4 N 0 O -3" xref: DiffMono: "-64.016044" xref: Formula: "C 5 H 4 N 2 O 1" xref: MassAvg: "108.10" xref: MassMono: "108.032363" xref: Origin: "D, G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00908 ! modified glycine residue is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly) [Term] id: MOD:00821 name: S-(L-alanyl)-L-cysteine def: "A protein modification that effectively crosslinks an L-alanine residue and an L-cysteine residue by a thioester bond to form S-(L-alanyl)-L-cysteine." [PubMed:11807079, RESID:AA0411] comment: Cross-link 2. synonym: "(2R)-2-amino-3-([(2S)-2-aminopropanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "alanine cysteine thioester" EXACT RESID-alternate [] synonym: "CROSSLNK Alanyl cysteine thioester (Cys-Ala)" EXACT UniProt-feature [] synonym: "S-(2-aminopropanoyl)cysteine" EXACT RESID-alternate [] synonym: "S-(L-alanyl)-L-cysteine" EXACT RESID-name [] synonym: "XLNK1AlaSCys" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 9 N 2 O 2 S 1" xref: MassAvg: "173.21" xref: MassMono: "173.038474" xref: Origin: "A, C" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00822 name: S-(L-leucyl)-L-cysteine def: "A protein modification that effectively crosslinks an L-leucine residue and an L-cysteine residue by a thioester bond to form S-(L-leucyl)-L-cysteine." [PubMed:12591958, RESID:AA0412] comment: Cross-link 2. synonym: "(2R)-2-amino-3-([(2S)-2-amino-4-methylpentanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Leucyl cysteine thioester (Cys-Leu)" EXACT UniProt-feature [] synonym: "leucine cysteine thioester" EXACT RESID-alternate [] synonym: "S-(2-amino-4-methylpentanoyl)cysteine" EXACT RESID-alternate [] synonym: "S-(L-leucyl)-L-cysteine" EXACT RESID-name [] synonym: "XLNK1LeuSCys" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 9 H 15 N 2 O 2 S 1" xref: MassAvg: "215.29" xref: MassMono: "215.085424" xref: Origin: "C, L" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00911 ! modified L-leucine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00823 name: S-(L-methionyl)-L-cysteine def: "A protein modification that effectively crosslinks an L-methionine residue and an L-cysteine residue by a thioester bond to form S-(L-methionyl)-L-cysteine." [PubMed:12146974, RESID:AA0413] comment: Cross-link 2. synonym: "(2R)-2-amino-3-([(2S)-2-amino-4-(methylsulfanyl)butanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Methionyl cysteine thioester (Cys-Met)" EXACT UniProt-feature [] synonym: "methionine cysteine thioester" EXACT RESID-alternate [] synonym: "S-(2-amino-4-methylthiobutanoyl)cysteine" EXACT RESID-alternate [] synonym: "S-(L-methionyl)-L-cysteine" EXACT RESID-name [] synonym: "XLNK1MetSCys" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 8 H 13 N 2 O 2 S 2" xref: MassAvg: "233.32" xref: MassMono: "233.041845" xref: Origin: "C, M" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00824 name: dehydroalanine (Tyr) def: "A protein modification that effectively converts an L-tyrosine residue to dehydroalanine." [PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:6838602, PubMed:7947813, PubMed:8239649, RESID:AA0181#TYR, UniMod:400] comment: incidental to RESID:AA0178 synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] synonym: "anhydroserine" EXACT RESID-alternate [] synonym: "dehydroalanine" EXACT RESID-name [] synonym: "Dha" EXACT RESID-alternate [] synonym: "dHAla(Tyr)" EXACT PSI-MOD-label [] xref: DiffAvg: "-94.11" xref: DiffFormula: "C -6 H -6 N 0 O -1" xref: DiffMono: "-94.041865" xref: Formula: "C 3 H 3 N 1 O 1" xref: MassAvg: "69.06" xref: MassMono: "69.021464" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01168 ! dehydroalanine [Term] id: MOD:00825 name: S-(L-phenylalanyl)-L-cysteine def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-cysteine residue by a thioester bond to form S-(L-phenylalaninyl)-L-cysteine." [PubMed:12591958, RESID:AA0414] comment: Cross-link 2. synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Phenylalanyl cysteine thioester (Cys-Phe)" EXACT UniProt-feature [] synonym: "phenylalanine cysteine thioester" EXACT RESID-alternate [] synonym: "S-(2-amino-3-phenylpropanoyl)cysteine" EXACT RESID-alternate [] synonym: "S-(L-phenylalanyl)-L-cysteine" EXACT RESID-name [] synonym: "XLNK1PheSCys" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 12 H 13 N 2 O 2 S 1" xref: MassAvg: "249.31" xref: MassMono: "249.069774" xref: Origin: "C, F" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00826 name: S-(L-threonyl)-L-cysteine def: "A protein modification that effectively crosslinks an L-threonine residue and an L-cysteine residue by a thioester bond to form S-(L-threonyl)-L-cysteine." [PubMed:15268951, RESID:AA0415] comment: Cross-link 2. synonym: "(2R)-2-amino-3-([(2S,3R)-2-amino-3-hydroxybutanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Threonyl cysteine thioester (Cys-Thr)" EXACT UniProt-feature [] synonym: "S-(2-amino-3-hydroxybutanoyl)cysteine" EXACT RESID-alternate [] synonym: "S-(L-threonyl)-L-cysteine" EXACT RESID-name [] synonym: "threonine cysteine thioester" EXACT RESID-alternate [] synonym: "XLNK1ThrSCys" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 7 H 11 N 2 O 3 S 1" xref: MassAvg: "203.24" xref: MassMono: "203.049038" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00827 name: S-(L-tyrosyl)-L-cysteine def: "A protein modification that effectively crosslinks an L-tyrosine residue and an L-cysteine residue by a thioester bond to form S-(L-tyrosyl)-L-cysteine." [PubMed:11807079, RESID:AA0416] comment: Cross-link 2. synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Tyrosyl cysteine thioester (Cys-Tyr)" EXACT UniProt-feature [] synonym: "S-(L-tyrosyl)-L-cysteine" EXACT RESID-name [] synonym: "S-[2-amino-3-(4-hydoxyphenyl)propanoyl]cysteine" EXACT RESID-alternate [] synonym: "tyrosine cysteine thioester" EXACT RESID-alternate [] synonym: "XLNK1TyrSCys" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 12 H 13 N 2 O 3 S 1" xref: MassAvg: "265.31" xref: MassMono: "265.064688" xref: Origin: "C, Y" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00828 name: S-(L-tryptophanyl)-L-cysteine def: "A protein modification that effectively crosslinks an L-tryptophan residue and an L-cysteine residue by a thioester bond to form S-(L-tryptophanyl)-L-cysteine." [PubMed:16030216, RESID:AA0417] comment: Cross-link 2. synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Tryptophanyl cysteine thioester (Cys-Trp)" EXACT UniProt-feature [] synonym: "S-(L-tryptophanyl)-L-cysteine" EXACT RESID-name [] synonym: "S-[2-amino-3-(1H-indol-3-yl)propanoyl]cysteine" EXACT RESID-alternate [] synonym: "tryptophan cysteine thioester" EXACT RESID-alternate [] synonym: "XLNK1TrpSCys" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 14 H 14 N 3 O 2 S 1" xref: MassAvg: "288.35" xref: MassMono: "288.080673" xref: Origin: "C, W" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00918 ! modified L-tryptophan residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00829 name: O-(L-phenylalanyl)-L-serine def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-serine residue by an ester bond to form S-(L-phenylalaninyl)-L-serine." [PubMed:12591958, RESID:AA0418] comment: Cross-link 2. synonym: "(2S)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]oxy)propanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Phenylalanyl serine ester (Ser-Phe)" EXACT UniProt-feature [] synonym: "O-(2-amino-3-phenylpropanoyl)serine" EXACT RESID-alternate [] synonym: "O-(L-phenylalanyl)-L-serine" EXACT RESID-name [] synonym: "phenylalanine serine ester" EXACT RESID-alternate [] synonym: "XLNK1PheOSer" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 12 H 13 N 2 O 3" xref: MassAvg: "233.25" xref: MassMono: "233.092617" xref: Origin: "F, S" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00885 ! ester crosslinked residues is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:00916 ! modified L-serine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00830 name: N-methyl-L-proline def: "A protein modification that effectively converts an L-proline residue to an N-methyl-L-proline." [PubMed:3127388, RESID:AA0419] comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. subset: PSI-MOD-slim synonym: "(S)-1-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "1-methylpyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] synonym: "hygric acid" EXACT RESID-alternate [] synonym: "MOD_RES N-methylproline" EXACT UniProt-feature [] synonym: "N-methyl-L-proline" EXACT RESID-name [] synonym: "N-methylated L-proline" EXACT PSI-MOD-alternate [] synonym: "NMePro" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 6 H 10 N 1 O 1" xref: MassAvg: "112.15" xref: MassMono: "112.076239" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01417 ! monomethylated proline is_a: MOD:01462 ! N-methylated proline is_a: MOD:01680 ! alpha-amino monomethylated residue [Term] id: MOD:00831 name: N4-(N-acetylamino)glucosyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine." [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var] subset: PSI-MOD-slim synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "N4GlcNAcAsn" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 12 H 19 N 3 O 7" xref: MassAvg: "317.30" xref: MassMono: "317.122300" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00448 ! N-acetylaminoglucosylated residue is_a: MOD:01674 ! N4-(N-acetylamino)hexosyl-L-asparagine [Term] id: MOD:00832 name: N4-(N-acetylamino)galactosyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminogalactosyl)-L-asparagine." [PubMed:8262914, RESID:AA0420] synonym: "(2S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "N4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-asparagine" EXACT RESID-alternate [] synonym: "N4-(2-acetylamino-2-deoxy-beta-D-galactopyranosyl)-L-asparagine" EXACT RESID-alternate [] synonym: "N4-(N-acetylamino)galactosyl-L-asparagine" EXACT RESID-name [] synonym: "N4-(N-acetylgalactosaminyl)asparagine" EXACT RESID-alternate [] synonym: "N4-asparagine-beta-N-acetylgalactosaminide" EXACT RESID-alternate [] synonym: "N4-glycosyl-L-asparagine" EXACT RESID-alternate [] synonym: "N4-glycosylasparagine" EXACT RESID-alternate [] synonym: "N4GalNAcAsn" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 12 H 19 N 3 O 7" xref: MassAvg: "317.30" xref: MassMono: "317.122300" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00563 ! N-acetylaminogalactosylated residue is_a: MOD:01674 ! N4-(N-acetylamino)hexosyl-L-asparagine [Term] id: MOD:00833 name: N4-glucosyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4-glucosyl-asparagine." [PubMed:1569073, PubMed:3410849, RESID:AA0421] synonym: "(2S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD N-linked (Glc)" EXACT UniProt-feature [] synonym: "N4-(D-glucopyranosyl)-L-asparagine" EXACT RESID-alternate [] synonym: "N4-asparagine-glucoside" EXACT RESID-alternate [] synonym: "N4-glucosyl-L-asparagine" EXACT RESID-name [] synonym: "N4-glucosylasparagine" EXACT RESID-alternate [] synonym: "N4-glycosyl-L-asparagine" EXACT RESID-alternate [] synonym: "N4-glycosylasparagine" EXACT RESID-alternate [] synonym: "N4GlcAsn" EXACT PSI-MOD-label [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 10 H 16 N 2 O 7" xref: MassAvg: "276.25" xref: MassMono: "276.095751" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00433 ! glucosylated residue is_a: MOD:00761 ! monohexosylated (Hex1) is_a: MOD:01346 ! N4-hexosylated asparagine [Term] id: MOD:00834 name: O-(N-acetylamino)fucosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetamino)fucosylserine." [PubMed:11342554, PubMed:12010970, RESID:AA0422] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-fucopyranosyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "O-(2-acetylamino-2-deoxy-beta-D-fucopyranosyl)-L-serine" EXACT RESID-alternate [] synonym: "O-(N-acetylamino)fucosyl-L-serine" EXACT RESID-name [] synonym: "O-(N-acetylfucosaminyl)serine" EXACT RESID-alternate [] synonym: "O-seryl-beta-N-acetylfucosaminide" EXACT RESID-alternate [] synonym: "O3-(2-acetamido-2-deoxy-beta-D-fucopyranosyl)-L-serine" EXACT RESID-alternate [] synonym: "O3-(N-acetylfucosaminyl)serine" EXACT RESID-alternate [] synonym: "OFucNAcSer" EXACT PSI-MOD-label [] xref: DiffAvg: "187.19" xref: DiffFormula: "C 8 H 13 N 1 O 4" xref: DiffMono: "187.084458" xref: Formula: "C 11 H 18 N 2 O 6" xref: MassAvg: "274.27" xref: MassMono: "274.116486" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine [Term] id: MOD:00835 name: L-3-oxoalanine (Ser) def: "A protein modification that effectively converts an L-serine residue to L-oxoalanine." [DeltaMass:349, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9276974, PubMed:9478923, RESID:AA0185#SER, UniMod:401#S] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate [] synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer [] synonym: "dehydrogenated serine residue" RELATED UniMod-description [] synonym: "Didehydro" RELATED PSI-MS-label [] synonym: "formylglycine" RELATED UniMod-alternate [] synonym: "formylglycine (from serine)" EXACT DeltaMass-label [] synonym: "L-3-oxoalanine" EXACT RESID-name [] synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate [] synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate [] synonym: "L-serinesemialdehyde" RELATED RESID-misnomer [] synonym: "MOD_RES 3-oxoalanine (Ser)" EXACT UniProt-feature [] synonym: "oxoalanine" RELATED UniMod-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 3 H 3 N 1 O 2" xref: MassAvg: "85.06" xref: MassMono: "85.016378" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01169 ! L-3-oxoalanine is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:00836 name: deuterium disubstituted residue def: "A protein modification that effectively substitutes two (2)H deuterium atoms for two (1)H protium atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "D(H)2Res" EXACT PSI-MOD-label [] is_a: MOD:00786 ! deuterium substituted residue [Term] id: MOD:00837 name: deuterium tetrasubstituted residue def: "A protein modification that effectively substitutes four (2)H deuterium atoms for four (1)H protium atoms." [PubMed:18688235] synonym: "D(H)4Res" EXACT PSI-MOD-label [] is_a: MOD:00786 ! deuterium substituted residue [Term] id: MOD:00838 name: 3x(2)H labeled L-leucine def: "A protein modification that effectively substitutes three (1)H protium atoms with three (2)H deuterium atoms to produce 3x(2)H labeled L-leucine." [UniMod:262#L] synonym: "D(H)3Leu" EXACT PSI-MOD-label [] synonym: "Label:2H(3)" RELATED PSI-MS-label [] synonym: "Trideuteration" RELATED UniMod-description [] xref: DiffAvg: "3.02" xref: DiffFormula: "(1)H -3 (2)H 3" xref: DiffMono: "3.018830" xref: Formula: "C 6 (1)H 8 (2)H 3 N 1 O 1" xref: MassAvg: "116.10" xref: MassMono: "116.102894" xref: Origin: "L" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00585 ! deuterium trisubstituted residue is_a: MOD:00911 ! modified L-leucine residue [Term] id: MOD:00839 name: (2)H deuterium labeled residue def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing deuteriumm, (2)H." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00702 ! isotope labeled residue [Term] id: MOD:00840 name: isocyanate reagent derivatized residue def: "A protein modification produced by formation of an adduct with an isocyanate compound." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00841 name: isothiocyanate reagent derivatized residue def: "A protein modification produced by formation of an adduct with an isothiocyanate compound." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00842 name: (13)C labeled residue def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (13)C." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00702 ! isotope labeled residue [Term] id: MOD:00843 name: (15)N labeled residue def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (15)N." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00702 ! isotope labeled residue [Term] id: MOD:00844 name: (18)O labeled residue def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (18)O." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00702 ! isotope labeled residue [Term] id: MOD:00845 name: (18)O substituted residue def: "A protein modification that effectively substitutes one or more (18)O atoms for (16)O atoms." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00844 ! (18)O labeled residue [Term] id: MOD:00846 name: levuglandinyl (prostaglandin H2) adduct def: "stub" [PubMed:18688235] is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00847 name: (18)O disubstituted residue def: "A protein modification that effectively substitutes two (18)O atom for two (16)O atoms." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00845 ! (18)O substituted residue [Term] id: MOD:00848 name: reagent derivatized residue def: "A protein modification that is produced by formation of an adduct with a particular compound used as a reagent." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00849 name: potassium containing modified residue def: "A protein modification that effectively substitutes a potassium atom for a hydrogen atom." [PubMed:18688235] subset: PSI-MOD-slim synonym: "KRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:00850 name: unnatural residue def: "A protein modification that inserts or replaces a residue with an unnatural residue that is not considered to be derived from a natural residue by some chemical process." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00851 name: (18)O labeled deamidated residue def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with (18)O." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00400 ! deamidated residue is_a: MOD:00844 ! (18)O labeled residue [Term] id: MOD:00852 name: 1x(18)O labeled deamidated residue def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with one (18)O." [PubMed:8382902, UniMod:366] subset: PSI-MOD-slim xref: DiffAvg: "2.99" xref: DiffFormula: "H -1 N -1 (18)O 1" xref: DiffMono: "2.988262" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00851 ! (18)O labeled deamidated residue [Term] id: MOD:00853 name: 2x(18)O labeled deamidated residue def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with two (18)O." [PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "4.99" xref: DiffFormula: "H -1 N -1 (16)O -1 (18)O 2" xref: DiffMono: "4.992508" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00851 ! (18)O labeled deamidated residue [Term] id: MOD:00854 name: protonated L-lysine (L-lysinium) residue def: "A protein modification that effectively converts an L-lysine to L-lysinium (protonated L-lysine)." [PubMed:18688235] comment: Some sources compute the difference formula for charged, quatenary modified lysine based on protonated lysine rather than neutral lysine residue. In such cases, a comparable difference formula can be calculated based on this derivative. subset: PSI-MOD-slim xref: DiffAvg: "1.01" xref: DiffFormula: "C 0 H 1 N 0 O 0" xref: DiffMono: "1.007276" xref: FormalCharge: "1+" xref: Formula: "C 6 H 13 N 2 O 1" xref: MassAvg: "129.18" xref: MassMono: "129.102239" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01699 ! protonated residue [Term] id: MOD:00855 name: N6,N6,N6-trimethyl-L-lysine (from L-lysinium residue) def: "A protein modification that effectively converts an L-lysinium (N6-protonated L-lysine) residue to an N6,N6,N6-trimethyl-L-lysine." [DeltaMass:0, OMSSA:15, PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, UniMod:37#K] comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N6Me3+Lys process (MOD:00083) accounts for both protonation and trimethylation. subset: PSI-MOD-slim synonym: "N6Me3Lys" EXACT PSI-MOD-label [] synonym: "trimethylk" EXACT OMSSA-label [] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6 N 0 O 0" xref: DiffMono: "42.046402" xref: FormalCharge: "1+" xref: Formula: "C 9 H 19 N 2 O 1" xref: MassAvg: "171.26" xref: MassMono: "171.149190" xref: Origin: "MOD:00854" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00430 ! trimethylated residue relationship: derives_from MOD:00854 ! protonated L-lysine (L-lysinium) residue [Term] id: MOD:00856 name: protonated L-alanine (L-alaninium) residue def: "A protein modification that effectively converts an L-alanine residue to an L-alaninium (protonated L-alanine)." [PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "1.01" xref: DiffFormula: "C 0 H 1 N 0 O 0" xref: DiffMono: "1.007276" xref: FormalCharge: "1+" xref: Formula: "C 3 H 7 N 1 O 1" xref: MassAvg: "73.09" xref: MassMono: "73.052215" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:01700 ! alpha-amino protonated residue [Term] id: MOD:00857 name: N,N,N-trimethyl-L-alanine (from L-alaninium) def: "A protein modification that effectively converts an L-alaninium (protonated L-alanine) residue to an N,N,N-trimethyl-L-alanine." [PubMed:12590383, PubMed:332162, PubMed:3979397, PubMed:6778808, PubMed:7715456, UniMod:37#A] comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ala process (MOD:00071) accounts for both protonation and trimethylation. subset: PSI-MOD-slim synonym: "N2Me3Ala" EXACT PSI-MOD-label [] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6 N 0 O 0" xref: DiffMono: "42.046402" xref: FormalCharge: "1+" xref: Formula: "C 6 H 13 N 1 O 1" xref: MassAvg: "115.18" xref: MassMono: "115.099165" xref: Origin: "MOD:00856" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01687 ! alpha-amino trimethylated residue relationship: derives_from MOD:00856 ! protonated L-alanine (L-alaninium) residue [Term] id: MOD:00858 name: D-alanine (Ser) def: "A protein modification that effectively converts an L-serine residue to D-alanine." [PubMed:7961627, RESID:AA0191#SER] synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic [] synonym: "D-Ala(Ser)" EXACT PSI-MOD-label [] synonym: "D-alanine" EXACT RESID-name [] synonym: "MOD_RES D-alanine (Ser)" EXACT UniProt-feature [] xref: DiffAvg: "-16.00" xref: DiffFormula: "C 0 H 0 N 0 O -1" xref: DiffMono: "-15.994915" xref: Formula: "C 3 H 5 N 1 O 1" xref: MassAvg: "71.08" xref: MassMono: "71.037114" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00862 ! D-alanine is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01161 ! deoxygenated residue [Term] id: MOD:00859 name: modified residue that can arise from different natural residues def: "A protein modification that can be derived from different natural residues by different chemical processes." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00860 name: sulfur containing modified residue def: "A protein modification that produces an amino acid residue containing an exogenous sulfur atom." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00861 name: phosphorus containing modified residue def: "A protein modification that produces an amino acid residue containing a phosphorus atom." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00862 name: D-alanine def: "A protein modification that effectively converts a source amino acid residue to D-alanine." [ChEBI:29949, PubMed:7287302, PubMed:7961627, RESID:AA0191] synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic [] synonym: "D-alanine" EXACT RESID-name [] synonym: "MOD_RES D-alanine (Ala)" EXACT UniProt-feature [] synonym: "MOD_RES D-alanine (Ser)" EXACT UniProt-feature [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 3 H 5 N 1 O 1" xref: MassAvg: "71.08" xref: MassMono: "71.037114" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:00863 name: D-allo-threonine def: "A protein modification that effectively converts an L-threonine residue to D-allo-threonine." [ChEBI:32826, PubMed:18025465, PubMed:6893271, RESID:AA0199] synonym: "(2R,3R)-2-amino-3-hydroxybutanoic acid" EXACT RESID-systematic [] synonym: "D-Thr" EXACT PSI-MOD-label [] synonym: "D-threonine" EXACT RESID-name [] synonym: "MOD_RES D-threonine" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 4 H 7 N 1 O 2" xref: MassAvg: "101.10" xref: MassMono: "101.047678" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:00864 name: tris-L-cysteinyl L-histidino diiron disulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-histidino diiron disulfide." [PubMed:17766439, PubMed:17766440, RESID:AA0438] comment: Cross-link 4. synonym: "CDGSH domain iron-sulfur cluster" EXACT RESID-alternate [] synonym: "di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-N3'-histidinoiron)" EXACT RESID-systematic [] synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature [] synonym: "METAL Iron-sulfur (2Fe-2S); via pros nitrogen" EXACT UniProt-feature [] synonym: "tris-L-cysteinyl L-histidino diiron disulfide" EXACT RESID-name [] xref: DiffAvg: "171.78" xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2" xref: DiffMono: "171.783814" xref: FormalCharge: "2-" xref: Formula: "C 15 Fe 2 H 18 N 6 O 4 S 5" xref: MassAvg: "618.34" xref: MassMono: "617.870280" xref: Origin: "C, C, C, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:00865 name: N-aspartyl-glycosylsphingolipidinositolethanolamine def: "A protein modification that effectively converts an L-aspartic acid residue to N-aspartyl-glycosylsphingolipidinositolethanolamine." [RESID:AA0439] synonym: "GSIAsp" EXACT PSI-MOD-label [] synonym: "LIPID GPI-like-anchor amidated aspartate" EXACT UniProt-feature [] synonym: "N-aspartyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 6 H 12 N 2 O 7 P 1" xref: MassAvg: "255.14" xref: MassMono: "255.038212" xref: Origin: "D" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00466 ! glycosylsphingolipidinositolated residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:00866 name: dihydroxylated proline def: "A protein modification that effectively converts an L-proline residue to one of several dihydroxylated proline residues, such as (2S,3R,4R)-3,4-dihydroxyproline or (2S,3R,4S)-3,4-dihydroxyproline." [PubMed:18688235] synonym: "Hy2Pro" EXACT PSI-MOD-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00428 ! dihydroxylated residue is_a: MOD:00678 ! hydroxylated proline [Term] id: MOD:00867 name: L-cysteinyl-L-selenocysteine (Cys-Cys) def: "A protein modification that effectively cross-links an L-cysteine residue and an L-cysteine converted to an L-selenocysteine residue to form L-cysteinyl-L-selenocystine." [PubMed:10801974, PubMed:12911312, PubMed:17177418, RESID:AA0358#CYS] comment: Cross-link 2. synonym: "(R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Cysteinyl-selenocysteine (Cys-Sec)" EXACT UniProt-feature [] synonym: "CROSSLNK Cysteinyl-selenocysteine (Sec-Cys)" EXACT UniProt-feature [] synonym: "L-cysteinyl-L-selenocysteine" EXACT RESID-name [] xref: DiffAvg: "44.90" xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1 Se 1" xref: DiffMono: "45.928800" xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1" xref: MassAvg: "251.17" xref: MassMono: "251.947170" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00007 ! selenium substitution for sulfur is_a: MOD:01627 ! L-cysteinyl-L-selenocysteine [Term] id: MOD:00868 name: natural, non-standard encoded residue def: "A protein modification that inserts or replaces a residue with a natural, non-standard encoded residue, such as N-formyl-L-methionine, L-selenocysteine, or L-pyrrolysine." [PubMed:18688235] comment: These are produced exclusively by modification of amino acids acylated to special tRNA before incorporation by ribosomes into proteins. For this reason, they have also been referred to as pre-translational modifications. subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "natural" is_a: MOD:00009 ! natural residue [Term] id: MOD:00869 name: L-alanine residue (Asp) def: "A protein modification that effectively converts an L-aspartic acid residue to L-alanine." [PubMed:17138938, RESID:AA0001#ASP] comment: This has been reported to occur by a natural process of beta-decarboxylation. synonym: "(2S)-2-aminopropanoic acid" EXACT RESID-systematic [] synonym: "2-aminopropionic acid" EXACT RESID-alternate [] synonym: "2-azanylpropanoic acid" EXACT RESID-alternate [] synonym: "alpha-alanine" EXACT RESID-alternate [] synonym: "alpha-aminopropionic acid" EXACT RESID-alternate [] synonym: "Asp(Ala)" EXACT PSI-MOD-label [] synonym: "L-alanine" EXACT RESID-name [] synonym: "MOD_RES Beta-decarboxylated aspartate" EXACT UniProt-feature [] xref: DiffAvg: "-44.01" xref: DiffFormula: "C -1 H 0 N 0 O -2" xref: DiffMono: "-43.989829" xref: Formula: "C 3 H 5 N 1 O 1" xref: MassAvg: "71.08" xref: MassMono: "71.037114" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00010 ! L-alanine residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:00870 name: phenyl isocyanate derivatized residue def: "A protein modification produced by formation of an adduct with phenyl isocyanate." [UniMod:411] comment: From UniMod with no citation. subset: PSI-MOD-slim synonym: "phenyl isocyanate" RELATED UniMod-description [] synonym: "Phenylisocyanate" RELATED PSI-MS-label [] xref: DiffAvg: "119.12" xref: DiffFormula: "C 7 H 5 N 1 O 1" xref: DiffMono: "119.037114" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00840 ! isocyanate reagent derivatized residue [Term] id: MOD:00871 name: (2)H5-phenyl isocyanate derivatized residue def: "A protein modification produced by formation of an adduct with (2)H5-phenyl isocyanate." [UniMod:412] comment: From UniMod with no citation. subset: PSI-MOD-slim synonym: "d5-phenyl isocyanate" RELATED UniMod-description [] synonym: "Phenylisocyanate:2H(5)" RELATED PSI-MS-label [] xref: DiffAvg: "124.07" xref: DiffFormula: "C 7 (2)H 5 N 1 O 1" xref: DiffMono: "124.068498" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00870 ! phenyl isocyanate derivatized residue is_a: MOD:01431 ! (2)H deuterium tagged reagent [Term] id: MOD:00872 name: L-isoglutamyl monoglutamic acid def: "OBSOLETE because redundant and identical to MOD:01970. Remap to MOD:01970." [PubMed:10747868, PubMed:15525938, PubMed:1680872, RESID:AA0202#var, UniMod:450] synonym: "Glu" RELATED UniMod-interim [] synonym: "monoglutamyl" RELATED UniMod-description [] synonym: "N alpha -(gamma-Glutamyl)-Glu" EXACT DeltaMass-label [] xref: DiffAvg: "129.12" xref: DiffFormula: "C 5 H 7 N 1 O 3" xref: DiffMono: "129.042593" xref: Formula: "C 10 H 14 N 2 O 6" xref: MassAvg: "258.23" xref: MassMono: "258.085186" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00873 name: L-isoglutamyl diglutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamic acid, forming an isopeptide bond with a diglutamic acid." [DeltaMass:0, PubMed:10747868, PubMed:1680872, RESID:AA0202#var, UniMod:451] synonym: "diglutamyl" RELATED UniMod-description [] synonym: "GluGlu" RELATED UniMod-interim [] xref: DiffAvg: "258.23" xref: DiffFormula: "C 10 H 14 N 2 O 6" xref: DiffMono: "258.085186" xref: Formula: "C 15 H 21 N 3 O 9" xref: MassAvg: "387.35" xref: MassMono: "387.127779" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid [Term] id: MOD:00874 name: L-isoglutamyl triglutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a triglutamic acid." [DeltaMass:0, PubMed:10747868, PubMed:1680872, RESID:AA0202#var, UniMod:452] comment: From DeltaMass: Average Mass: 388. synonym: "GluGluGlu" RELATED UniMod-interim [] synonym: "N alpha -(gamma-Glutamyl)-Glu3" EXACT DeltaMass-label [] synonym: "triglutamyl" RELATED UniMod-description [] xref: DiffAvg: "387.35" xref: DiffFormula: "C 15 H 21 N 3 O 9" xref: DiffMono: "387.127779" xref: Formula: "C 20 H 28 N 4 O 12" xref: MassAvg: "516.46" xref: MassMono: "516.170372" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid [Term] id: MOD:00875 name: L-isoglutamyl tetraglutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a tetraglutamic acid." [PubMed:10747868, PubMed:1680872, RESID:AA0202#var, UniMod:453] synonym: "GluGluGluGlu" RELATED UniMod-interim [] synonym: "tetraglutamyl" RELATED UniMod-description [] xref: DiffAvg: "516.46" xref: DiffFormula: "C 20 H 28 N 4 O 12" xref: DiffMono: "516.170372" xref: Formula: "C 25 H 35 N 5 O 15" xref: MassAvg: "645.57" xref: MassMono: "645.212965" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid [Term] id: MOD:00876 name: hexosaminylated residue def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosamine sugar group through a glycosidic bond." [UniMod:454] synonym: "HexN" RELATED PSI-MS-label [] synonym: "Hexosamine" RELATED UniMod-description [] synonym: "Hexosamines (GalN, GlcN)" EXACT DeltaMass-label [] xref: DiffAvg: "161.16" xref: DiffFormula: "C 6 H 11 N 1 O 4" xref: DiffMono: "161.068808" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00877 name: imidoester crosslink dimethyl pimelimidate singly attached def: "dimethyl pimelimidate modification from UniMod" [UniMod:455, URL:http\://www.piercenet.com/files/0668ss5.pdf] synonym: "One end of crosslink attached, one end free" RELATED UniMod-description [] synonym: "Xlink:DMP-s" RELATED UniMod-interim [] xref: DiffAvg: "154.21" xref: DiffFormula: "C 8 H 14 N 2 O 1" xref: DiffMono: "154.110613" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00878 name: imidoester crosslink dimethyl pimelimidate doubly attached def: "dimethyl pimelimidate modification from UniMod - Mechanism of the reaction of imidoesters with amines" [PubMed:7171546, UniMod:456, URL:http\://dx.doi.org/10.1021/ja00877a017] synonym: "Both ends of crosslink attached to same peptide" RELATED UniMod-description [] synonym: "Xlink:DMP" RELATED UniMod-interim [] xref: DiffAvg: "122.17" xref: DiffFormula: "C 7 H 10 N 2" xref: DiffMono: "122.084398" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00879 name: naphthalene-2,3-dicarboxaldehyde def: "modification from UniMod" [PubMed:2081203, UniMod:457] synonym: "naphthalene-2,3-dicarboxaldehyde" RELATED UniMod-description [] synonym: "NDA" RELATED UniMod-interim [] xref: DiffAvg: "175.19" xref: DiffFormula: "C 13 H 5 N 1" xref: DiffMono: "175.042199" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00880 name: 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue def: "A protein modification produced by formation of an adduct with 6x(13)C labeled 4-sulfophenyl isothiocyanate." [PubMed:15536630, PubMed:16526082, UniMod:464] synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED UniMod-description [] synonym: "SPITC:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "220.99" xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2" xref: DiffMono: "220.991214" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue is_a: MOD:01428 ! (13)C isotope tagged reagent [Term] id: MOD:00881 name: N-reductive amination-D def: "OBSOLETE because UniMod entry 465 megerd with 199. Remap to MOD:00552 DiMethyl-CH2D." [PubMed:9252331, UniMod:465] xref: DiffAvg: "32.06" xref: DiffFormula: "C 2 (2)H 4" xref: DiffMono: "32.056407" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00882 name: S-(2-aminoethyl)cysteine (Ser) def: "A protein modification that effectively converts an L-serine residue to S-(2-aminoethyl)cysteine." [DeltaMass:171, PubMed:12923550, UniMod:472#S] comment: From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. synonym: "AEC-MAEC" RELATED UniMod-interim [] synonym: "Aminoethyl Cysteinyl (AECys)" EXACT DeltaMass-label [] synonym: "aminoethylcysteine" RELATED UniMod-description [] xref: DiffAvg: "59.13" xref: DiffFormula: "C 2 H 5 N 1 O -1 S 1" xref: DiffMono: "59.019356" xref: Formula: "C 5 H 10 N 2 O 1 S 1" xref: MassAvg: "146.21" xref: MassMono: "146.051384" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00883 name: C1-amidated residue def: "A protein modification that effectively replaces a 1-carboxyl group (usually referred to as the alpha-carboxyl) with a carboxamido group." [DeltaMass:0, OMSSA:25, UniMod:2] comment: The normal biological process involves formation of an amide of an amino acid residue in a peptide sequence where it is followed by a glycine and two basic residues, either arginine or lysine, although in some taxa only one basic residue is required. The peptide is cleaved after the basic residues, glycine is oxidized to hydroxyglycine, which decomposes to release a carboxamide C-terminal [JSG]. subset: PSI-MOD-slim synonym: "alpha-amidated residue" EXACT PSI-MOD-alternate [] synonym: "Amidated" RELATED PSI-MS-label [] synonym: "Amidation" RELATED UniMod-description [] synonym: "Amide formation (C terminus)" EXACT DeltaMass-label [] synonym: "ctermamide" EXACT OMSSA-label [] synonym: "ResN" EXACT PSI-MOD-label [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00674 ! amidated residue [Term] id: MOD:00884 name: S-aminoethylcysteine (Cys) def: "A protein modification that effectively converts an L-cysteine residue to S-2-aminoethylcysteine." [PubMed:1175632, PubMed:18688235] comment: This modified residue is a chemical isolog of L-lysine for trypsin hydolysis produced from L-cysteine by aziridine. subset: PSI-MOD-slim synonym: "4-thialysine" EXACT PSI-MOD-alternate [] synonym: "L-cysteine aziridine adduct" EXACT PSI-MOD-alternate [] synonym: "S-(2-aminoethyl)-L-cysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "43.07" xref: DiffFormula: "C 2 H 5 N 1 O 0 S 0" xref: DiffMono: "43.042199" xref: Formula: "C 5 H 10 N 2 O 1 S 1" xref: MassAvg: "146.21" xref: MassMono: "146.051384" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00885 name: ester crosslinked residues def: "A protein modification that crosslinks two residues by formation of an ester bond." [PubMed:18688235] is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:00886 name: 6'-chloro-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 6'-chloro-L-tryptophan." [PubMed:9033387, RESID:AA0180, UniMod:936#W] comment: The UniMod:340 cross-reference to RESID:AA0180 is incorrect. RESID:AA0180 should be cross-referenced by UniMod:936 [JSG]. synonym: "(2S)-2-amino-3-(6-chloro-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "6'-chloro-L-tryptophan" EXACT RESID-name [] synonym: "6'-ClTrp" EXACT PSI-MOD-label [] synonym: "MOD_RES 6'-chlorotryptophan" EXACT UniProt-feature [] xref: DiffAvg: "34.44" xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" xref: DiffMono: "33.961028" xref: Formula: "C 11 Cl 1 H 9 N 2 O 1" xref: MassAvg: "220.66" xref: MassMono: "220.040341" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01913 ! monochlorinated L-tryptophan [Term] id: MOD:00887 name: methylated aspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to a methylated aspartic acid, such as aspartic acid 4-methyl ester." [PubMed:18688235] is_a: MOD:00427 ! methylated residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:00888 name: protonated L-proline (L-prolinium) residue def: "A protein modification that effectively converts an L-proline to an L-prolinium (protonated L-proline)." [PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "1.01" xref: DiffFormula: "C 0 H 1 N 0 O 0" xref: DiffMono: "1.007276" xref: FormalCharge: "1+" xref: Formula: "C 5 H 9 N 1 O 1" xref: MassAvg: "99.13" xref: MassMono: "99.067865" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01700 ! alpha-amino protonated residue [Term] id: MOD:00889 name: N,N-dimethyl-L-proline (from L-prolinium) def: "A protein modification that effectively converts an L-prolinium (charged L-proline) residue to N,N-dimethyl-L-proline." [UniMod:36#P] subset: PSI-MOD-slim xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.030752" xref: FormalCharge: "1+" xref: Formula: "C 7 H 13 N 1 O 1" xref: MassAvg: "127.19" xref: MassMono: "127.099165" xref: Origin: "MOD:00888" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00075 ! N,N-dimethyl-L-proline relationship: derives_from MOD:00888 ! protonated L-proline (L-prolinium) residue [Term] id: MOD:00890 name: phosphorylated L-histidine def: "A protein modification that effectively converts an L-histidine residue to a phosphorylated L-histidine, such as pros-phosphohistidine, or tele-phosphohistidine." [OMSSA:192, UniMod:21#H] subset: PSI-MOD-slim synonym: "mod192" EXACT OMSSA-label [] synonym: "NPhosHis" EXACT PSI-MOD-label [] synonym: "Phospho" RELATED PSI-MS-label [] synonym: "phosphohistidine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 6 H 8 N 3 O 4 P 1" xref: MassAvg: "217.12" xref: MassMono: "217.025242" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01456 ! N-phosphorylated residue [Term] id: MOD:00891 name: D-serine def: "A protein modification that effectively converts a source amino acid residue to D-serine." [ChEBI:29998, PubMed:6893271, PubMed:7973665, RESID:AA0195] synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic [] synonym: "D-Ser" EXACT PSI-MOD-label [] synonym: "D-serine" EXACT RESID-name [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 3 H 5 N 1 O 2" xref: MassAvg: "87.08" xref: MassMono: "87.032028" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:00892 name: D-serine (Cys) def: "A protein modification that effectively converts an L-cysteine residue to D-serine." [PubMed:18025465, PubMed:6893271, RESID:AA0195#CYS] synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic [] synonym: "D-serine" EXACT RESID-name [] xref: DiffAvg: "-16.06" xref: DiffFormula: "C 0 H 0 N 0 O 1 S -1" xref: DiffMono: "-15.977156" xref: Formula: "C 3 H 5 N 1 O 2" xref: MassAvg: "87.08" xref: MassMono: "87.032028" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00891 ! D-serine is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00893 name: residues isobaric at 128.0-128.1 def: "Natural or modified residues with a mass of 128.0-128.1 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da [Term] id: MOD:00894 name: residues isobaric at 128.058578 Da def: "Natural or modified resiues with a mass of 128.058578 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da is_a: MOD:00893 ! residues isobaric at 128.0-128.1 [Term] id: MOD:00895 name: FAD modified residue def: "A protein modification that effectively results from forming an adduct with a compound containing a flavin adenine dinucleotide (FAD) group." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00697 ! flavin modified residue is_a: MOD:00861 ! phosphorus containing modified residue [Term] id: MOD:00896 name: FMN modified residue def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00697 ! flavin modified residue is_a: MOD:00861 ! phosphorus containing modified residue [Term] id: MOD:00897 name: N-acetyl-S-archeol-cysteine def: "A protein modification that effectively converts an L-cysteine residue to N-acetyl-S-archeol-L-cysteine." [RESID:AA0043#var, RESID:AA0223#var] xref: DiffAvg: "677.20" xref: DiffFormula: "C 45 H 88 N 0 O 3 S 0" xref: DiffMono: "676.673347" xref: Formula: "C 48 H 93 N 1 O 4 S 1" xref: MassAvg: "780.34" xref: MassMono: "779.682531" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00905 ! modified L-cysteine residue relationship: has_functional_parent MOD:00052 ! N-acetyl-L-cysteine relationship: has_functional_parent MOD:00228 ! S-diphytanylglycerol diether-L-cysteine [Term] id: MOD:00898 name: S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107#var, UniMod:377] comment: Incidental to RESID:AA0060. synonym: "Diacylglycerol" RELATED PSI-MS-label [] synonym: "diacylglycerol" RELATED UniMod-description [] xref: DiffAvg: "576.95" xref: DiffFormula: "C 37 H 68 N 0 O 4 S 0" xref: DiffMono: "576.511761" xref: Formula: "C 40 H 73 N 1 O 5 S 1" xref: MassAvg: "680.09" xref: MassMono: "679.520945" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00116 ! S-diacylglycerol-L-cysteine [Term] id: MOD:00899 name: N-palmitoyl-S-diacylglycerol-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-diacylglycerol-L-cysteine." [RESID:AA0069#var, RESID:AA0107#var] xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00905 ! modified L-cysteine residue relationship: has_functional_parent MOD:00069 ! N-palmitoyl-L-cysteine relationship: has_functional_parent MOD:00116 ! S-diacylglycerol-L-cysteine [Term] id: MOD:00900 name: N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine." [PubMed:18688235] synonym: "(R)-2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid" EXACT PSI-MOD-alternate [] synonym: "2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid" EXACT PSI-MOD-alternate [] xref: DiffAvg: "815.36" xref: DiffFormula: "C 53 H 98 N 0 O 5 S 0" xref: DiffMono: "814.741426" xref: Formula: "C 56 H 103 N 1 O 6 S 1" xref: MassAvg: "918.50" xref: MassMono: "917.750611" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00899 ! N-palmitoyl-S-diacylglycerol-L-cysteine relationship: has_functional_parent MOD:00069 ! N-palmitoyl-L-cysteine relationship: has_functional_parent MOD:00898 ! S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine [Term] id: MOD:00901 name: modified L-alanine residue def: "A protein modification that modifies an L-alanine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModAla" EXACT PSI-MOD-label [] xref: Origin: "A" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00902 name: modified L-arginine residue def: "A protein modification that modifies an L-arginine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModArg" EXACT PSI-MOD-label [] xref: Origin: "R" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00903 name: modified L-asparagine residue def: "A protein modification that modifies an L-asparagine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModAsn" EXACT PSI-MOD-label [] xref: Origin: "N" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00904 name: modified L-aspartic acid residue def: "A protein modification that modifies an L-aspartic acid residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModAsp" EXACT PSI-MOD-label [] xref: Origin: "D" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00905 name: modified L-cysteine residue def: "A protein modification that modifies an L-cysteine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModCys" EXACT PSI-MOD-label [] xref: Origin: "C" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00906 name: modified L-glutamic acid residue def: "A protein modification that modifies an L-glutamic acid residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModGlu" EXACT PSI-MOD-label [] xref: Origin: "E" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00907 name: modified L-glutamine residue def: "A protein modification that modifies an L-glutamine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModGln" EXACT PSI-MOD-label [] xref: Origin: "Q" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00908 name: modified glycine residue def: "A protein modification that modifies a glycine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModGly" EXACT PSI-MOD-label [] xref: Origin: "G" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00909 name: modified L-histidine residue def: "A protein modification that modifies an L-histidine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModHis" EXACT PSI-MOD-label [] xref: Origin: "H" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00910 name: modified L-isoleucine residue def: "A protein modification that modifies an L-isoleucine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModIle" EXACT PSI-MOD-label [] xref: Origin: "I" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00911 name: modified L-leucine residue def: "A protein modification that modifies an L-leucine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModLeu" EXACT PSI-MOD-label [] xref: Origin: "L" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00912 name: modified L-lysine residue def: "A protein modification that modifies an L-lysine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModLys" EXACT PSI-MOD-label [] xref: Origin: "K" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00913 name: modified L-methionine residue def: "A protein modification that modifies an L-methionine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModMet" EXACT PSI-MOD-label [] xref: Origin: "M" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00914 name: modified L-phenylalanine residue def: "A protein modification that modifies an L-phenylalanine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModPhe" EXACT PSI-MOD-label [] xref: Origin: "F" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00915 name: modified L-proline residue def: "A protein modification that modifies an L-proline residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModPro" EXACT PSI-MOD-label [] xref: Origin: "P" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00916 name: modified L-serine residue def: "A protein modification that modifies an L-serine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModSer" EXACT PSI-MOD-label [] xref: Origin: "S" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00917 name: modified L-threonine residue def: "A protein modification that modifies an L-threonine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModThr" EXACT PSI-MOD-label [] xref: Origin: "T" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00918 name: modified L-tryptophan residue def: "A protein modification that modifies an L-tryptophan residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModTrp" EXACT PSI-MOD-label [] xref: Origin: "W" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00919 name: modified L-tyrosine residue def: "A protein modification that modifies an L-tyrosine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModTyr" EXACT PSI-MOD-label [] xref: Origin: "Y" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00920 name: modified L-valine residue def: "A protein modification that modifies an L-valine residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ModVal" EXACT PSI-MOD-label [] xref: Origin: "V" is_a: MOD:01157 ! protein modification categorized by amino acid modified [Term] id: MOD:00921 name: new uncategorized UniMod entries def: "New uncategorized UniMod. OBSOLETE because organizational use is no longer required." [PubMed:18688235] is_obsolete: true [Term] id: MOD:00922 name: Cy3 CyDye DIGE Fluor saturation dye def: "modification from UniMod Chemical derivative" [UniMod:494] synonym: "Cy3 CyDye DIGE Fluor saturation dye" RELATED UniMod-description [] synonym: "CyDye-Cy3" RELATED UniMod-interim [] xref: DiffAvg: "672.84" xref: DiffFormula: "C 37 H 44 N 4 O 6 S 1" xref: DiffMono: "672.298156" xref: Formula: "C 40 H 49 N 5 O 7 S 2" xref: MassAvg: "775.98" xref: MassMono: "775.307341" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00923 name: Cy5 CyDye DIGE Fluor saturation dye def: "modification from UniMod Chemical derivative" [UniMod:495] synonym: "Cy5 CyDye DIGE Fluor saturation dye" RELATED UniMod-description [] synonym: "CyDye-Cy5" RELATED UniMod-interim [] xref: DiffAvg: "684.85" xref: DiffFormula: "C 38 H 44 N 4 O 6 S 1" xref: DiffMono: "684.298156" xref: Formula: "C 41 H 49 N 5 O 7 S 2" xref: MassAvg: "787.99" xref: MassMono: "787.307341" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00924 name: N6-(L-threonyl)-L-lysine def: "A protein modification that effectively crosslinks an L-lysine residue and an L-threonine residue by an isopeptide bond to form N6-(L-threonyl)-L-lysine." [PubMed:18063774, RESID:AA0440] comment: Cross-link 2. synonym: "(2S)-2-amino-6-([(2S,3R)-2-amino-3-hydroxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "N6-(L-threonyl)-L-lysine" EXACT RESID-name [] synonym: "N6-threonyl-lysine" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 10 H 18 N 3 O 3" xref: MassAvg: "228.27" xref: MassMono: "228.134816" xref: Origin: "K, T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00688 ! isopeptide crosslinked residues is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:00925 name: heptosylated residue def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a heptose sugar group through a glycosidic bond." [UniMod:490] comment: From UniMod with no citation [JSG]. synonym: "Hep" RELATED PSI-MS-label [] synonym: "Heptose" RELATED UniMod-description [] xref: DiffAvg: "192.17" xref: DiffFormula: "C 7 H 12 O 6" xref: DiffMono: "192.063388" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00693 ! glycosylated residue [Term] id: MOD:00926 name: Bisphenol A diglycidyl ether derivative def: "Modification from UniMod Non-standard residue. OBSOLETE because not an amino acid modification. From UniMod not an approved entry." [PubMed:11225353, UniMod:493] synonym: "BADGE" RELATED UniMod-interim [] synonym: "Bisphenol A diglycidyl ether derivative" RELATED UniMod-description [] xref: DiffAvg: "340.42" xref: DiffFormula: "C 21 H 24 O 4" xref: DiffMono: "340.167459" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00927 name: 2x(13)C,4x(2)H labeled dimethylated residue def: "A protein modification that effectively replaces two hydrogen atoms of a residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated residue." [PubMed:16335955, PubMed:3802193, UniMod:510] synonym: "DiMethyl-C13HD2" RELATED UniMod-description [] synonym: "Dimethyl:2H(4)13C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "34.06" xref: DiffFormula: "(13)C 2 (2)H 4" xref: DiffMono: "34.063117" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00839 ! (2)H deuterium labeled residue is_a: MOD:00842 ! (13)C labeled residue [Term] id: MOD:00928 name: [3-(2,5)-dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium def: "modification from UniMod Chemical derivative" [PubMed:16771548, UniMod:513] comment: Should have children for K and X-N-term [JSG]. synonym: "[3-(2,5)-Dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium" RELATED UniMod-description [] synonym: "C8-QAT" RELATED UniMod-interim [] xref: DiffAvg: "227.39" xref: DiffFormula: "C 14 H 29 N 1 O 1" xref: DiffMono: "227.224915" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00929 name: lactose glycated lysine def: "A modification produced in a non-enzymatic reaction between a lactose carbonyl group and an L-lysine to form a Schiff-base or an Amadori ketosamine lysine adduct." [PubMed:9606156, UniMod:512] comment: The term lactosylation used with this meaning is a misnomer [JSG]. synonym: "Hex(2)" RELATED UniMod-interim [] synonym: "Lactosylation" RELATED UniMod-description [] xref: DiffAvg: "342.30" xref: DiffFormula: "C 12 H 22 O 11" xref: DiffMono: "342.116212" xref: Formula: "C 18 H 34 N 2 O 12" xref: MassAvg: "470.47" xref: MassMono: "470.211175" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00767 ! glycated residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00930 name: propyl-NAG tyrosine adduct def: "tyrosine adduct with substrate analog inhibitor 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline." [PubMed:15795231, UniMod:514] xref: DiffAvg: "232.27" xref: DiffFormula: "C 9 H 14 N 1 O 4 S 1" xref: DiffMono: "232.064354" xref: Formula: "C 18 H 23 N 2 O 6 S 1" xref: MassAvg: "395.45" xref: MassMono: "395.127682" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00931 name: Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K def: "modification from UniMod Other - BHTOH is formed upon metabolism of BHT with P450 enzymes. The BHTOH is further metabolized to its quinone methide (electrophile) which reacts with -SH and -NH2 groups" [PubMed:11085420, UniMod:498] synonym: "BHTOH" RELATED UniMod-interim [] synonym: "Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K" RELATED UniMod-description [] xref: DiffAvg: "234.34" xref: DiffFormula: "C 15 H 22 O 2" xref: DiffMono: "234.161980" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00932 name: IDBEST tag for quantitation def: "modification from UniMod Isotopic label" [PubMed:11821862, UniMod:499] synonym: "Heavy IDBEST tag for quantitation" RELATED UniMod-description [] synonym: "IGBP:13C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "298.02" xref: DiffFormula: "Br 1 (12)C 10 (13)C 2 H 13 N 2 O 2" xref: DiffMono: "298.022749" xref: Formula: "Br 1 (12)C 13 (13)C 2 H 18 N 3 O 3 S 1" xref: MassAvg: "401.03" xref: MassMono: "401.031934" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:00933 name: methylglyoxal arginine adduct (+54 amu) def: "modification from UniMod Chemical derivative - 5-hydro-5-methylimidazol-4-one, arginine methylglyoxal arginine adduct (+54 amu)" [UniMod:319#R] comment: Ref. Uchida K, Sakai K, Itakura K, Osawa T, Toyokuni S. 1977. Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins. Arch Biochem Biophys. 346(1):45-52. synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label [] synonym: "MDA adduct +54" RELATED UniMod-description [] xref: DiffAvg: "54.05" xref: DiffFormula: "C 3 H 2 O 1" xref: DiffMono: "54.010565" xref: Formula: "C 9 H 14 N 4 O 2" xref: MassAvg: "210.24" xref: MassMono: "210.111676" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00630 ! C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00934 name: Levuglandinyl - arginine hydroxylactam adduct def: "modification from UniMod Post-translational" [UniMod:506] synonym: "Levuglandinyl - arginine hydroxylactam adduct" RELATED UniMod-description [] synonym: "LG-Hlactam-R" RELATED UniMod-interim [] xref: DiffAvg: "306.40" xref: DiffFormula: "C 19 H 26 N -2 O 5" xref: DiffMono: "306.171876" xref: Formula: "C 25 H 38 N 2 O 6" xref: MassAvg: "462.59" xref: MassMono: "462.272987" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00935 name: methionine oxidation with neutral loss of 64 Da def: "Oxidation of methionine to methionine sulfoxide with neutral loss of CH3SOH." [PubMed:18688235, PubMed:9004526] comment: Originally created from UniMod:507 that was later deleted. xref: DiffAvg: "-64.10" xref: DiffFormula: "C -1 H -4 N 0 O -1 S -1" xref: DiffMono: "-63.998286" xref: Formula: "C 4 H 5 N 1 O 1 S 0" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00431 ! modified residue with a secondary neutral loss is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:00936 name: Levuglandinyl - hydroxylactam adduct, K and N-term def: "modification from UniMod Post-translational" [UniMod:504] synonym: "Levuglandinyl - lysine hydroxylactam adduct" RELATED UniMod-description [] synonym: "LG-Hlactam-K" RELATED UniMod-interim [] xref: DiffAvg: "348.44" xref: DiffFormula: "C 20 H 28 O 5" xref: DiffMono: "348.193674" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct [Term] id: MOD:00937 name: Levuglandinyl - arginine lactam adduct def: "modification from UniMod Post-translational" [UniMod:505] synonym: "Levuglandinyl - arginine lactam adduct" RELATED UniMod-description [] synonym: "LG-lactam-R" RELATED UniMod-interim [] xref: DiffAvg: "290.40" xref: DiffFormula: "C 19 H 26 N -2 O 4" xref: DiffMono: "290.176961" xref: Formula: "C 25 H 38 N 2 O 5" xref: MassAvg: "446.59" xref: MassMono: "446.278072" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:00938 name: Levuglandinyl - lactam adduct, K and N-term def: "modification from UniMod Post-translational" [PubMed:12590383, UniMod:503] synonym: "Levuglandinyl - lysine lactam adduct" RELATED UniMod-description [] synonym: "LG-lactam-K" RELATED UniMod-interim [] xref: DiffAvg: "332.44" xref: DiffFormula: "C 20 H 28 O 4" xref: DiffMono: "332.198759" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct [Term] id: MOD:00939 name: hydrolyzed N-methylmaleimide cysteine adduct def: "modification from UniMod Chemical derivative" [UniMod:500] synonym: "Nmethylmaleimide+water" RELATED UniMod-interim [] synonym: "Nmethylmaleimidehydrolysis" RELATED UniMod-description [] xref: DiffAvg: "129.12" xref: DiffFormula: "C 5 H 7 N 1 O 3" xref: DiffMono: "129.042593" xref: Formula: "C 8 H 12 N 2 O 4 S 1" xref: MassAvg: "232.25" xref: MassMono: "232.051778" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00940 name: 3-methyl-2-pyridyl isocyanate derivatized residue def: "A protein modification produced by formation of an adduct with 3-methyl-2-pyridyl isocyanate." [PubMed:11078590, UniMod:501] synonym: "3-methyl-2-pyridyl isocyanate" RELATED UniMod-description [] synonym: "PyMIC" RELATED UniMod-interim [] xref: DiffAvg: "134.14" xref: DiffFormula: "C 7 H 6 N 2 O 1" xref: DiffMono: "134.048013" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00840 ! isocyanate reagent derivatized residue [Term] id: MOD:00941 name: dehydropyrrolizidine alkaloid (dehydroretronecine) derivatized cysteine def: "modification from UniMod Chemical derivative" [PubMed:12175151, UniMod:488] synonym: "Dehydropyrrolizidine alkaloid (dehydroretronecine) on cysteines" RELATED UniMod-description [] synonym: "DHP" RELATED UniMod-interim [] xref: DiffAvg: "118.16" xref: DiffFormula: "C 8 H 8 N 1" xref: DiffMono: "118.065674" xref: Formula: "C 11 H 13 N 2 S 1" xref: MassAvg: "205.30" xref: MassMono: "205.079944" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00942 name: (4,4,5,5-(2)H4)-L-lysine def: "A protein modification that effectively substitutes four (1)H protium atoms with four (2)H deuterium atoms to produce (4,4,5,5-(2)H4)-L-lysine." [OMSSA:180, UniMod:481] comment: For SILAC experiments. synonym: "4,4,5,5-D4 Lysine" RELATED UniMod-description [] synonym: "4,4,5,5-tetradeuterolysine" EXACT PSI-MOD-alternate [] synonym: "Label:2H(4)" RELATED UniMod-interim [] synonym: "lys-2H4" EXACT OMSSA-label [] xref: DiffAvg: "4.03" xref: DiffFormula: "(1)H -4 (2)H 4" xref: DiffMono: "4.025107" xref: Formula: "C 6 (1)H 8 (2)H 4 N 2 O 1" xref: MassAvg: "132.12" xref: MassMono: "132.120070" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00837 ! deuterium tetrasubstituted residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:00943 name: 4-trimethylammoniumbutanoyl derivatized residue def: "modification from UniMod Isotopic label" [PubMed:12643539, UniMod:476] synonym: "4-trimethyllammoniumbutyryl-" RELATED UniMod-description [] synonym: "TMAB" RELATED UniMod-interim [] xref: DiffAvg: "128.19" xref: DiffFormula: "C 7 H 14 N 1 O 1" xref: DiffMono: "128.107539" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00944 name: d9-4-trimethylammoniumbutanoyl derivatized residue def: "modification from UniMod Isotopic label" [UniMod:477] synonym: "d9-4-trimethyllammoniumbutyryl-" RELATED UniMod-description [] synonym: "TMAB:2H(9)" RELATED UniMod-interim [] xref: DiffAvg: "137.16" xref: DiffFormula: "C 7 (1)H 5 (2)H 9 N 1 O 1" xref: DiffMono: "137.164030" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00943 ! 4-trimethylammoniumbutanoyl derivatized residue is_a: MOD:01431 ! (2)H deuterium tagged reagent [Term] id: MOD:00945 name: fluorescein-5-thiosemicarbazide adduct def: "OBSOLETE because redundant and identical to MOD:00626. Remap to MOD:00626." [PubMed:18688235] xref: DiffAvg: "421.43" xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" xref: DiffMono: "421.073242" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00946 name: crosslinked residues with loss of ammonia def: "A protein modification that crosslinks two residues with a covalent bond and the loss of ammonia." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:00947 name: DeltaMass def: "Entries from DeltaMass see http://www.abrf.org/index.cfm/dm.home?AvgMass=all." [PubMed:18688235] is_a: MOD:00032 ! uncategorized protein modification [Term] id: MOD:00948 name: 5'-dephospho def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: -79 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00949 name: desmosine def: "OBSOLETE because redundant and identical to MOD:01933. Remap to MOD:01933." [DeltaMass:0] comment: From DeltaMass: Average Mass: -58 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "K" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00950 name: decomposed carboxymethylated methionine def: "modification from DeltaMass" [DeltaMass:3] comment: From DeltaMass: Average Mass: -48 Average Mass Change:-48 References:Anal. Biochem. Vol 216 No.1 p141 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "M" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00951 name: L-gamma-carboxyglutamic acid with neutral loss of carbon dioxide def: "Covalent modification of a peptide or protein L-glutamic acid residue to gamma-carboxyglutamic acid with secondary loss of a neutral carbon dioxide molecular fragment." [DeltaMass:58] comment: From DeltaMass: Average Mass: -44 Formula:CO2 Average Mass Change:-44 References:Nakamura T, Yu Z, Fainzilber M, Burlingame AL. Protein Sci (1996) 5, 524-530 Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile. Notes: The elimination of CO2 will regenerate glutamate as if there was no modification. However, peaks appearing with an interval of 44 is quite characteristic. It would be noteworthy to remind that loss of 44 from a gamma-carboxyglutamate-containing peptide may be observed not only as a result of spontaneous decarboxylation but also as an artifact under some ionization conditions such as negative ion mode MALDI. synonym: "d4CbxGlu" EXACT PSI-MOD-label [] xref: DiffAvg: "-44.01" xref: DiffFormula: "C -1 H 0 N 0 O -2" xref: DiffMono: "-43.989829" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00015 ! L-glutamic acid residue is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00957 ! modified residue with neutral loss of carbon dioxide is_a: MOD:00960 ! decarboxylated residue [Term] id: MOD:00952 name: (2-aminosuccinimidyl)acetic acid (Asp) def: "A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the loss of a water molecule." [PubMed:10801322, RESID:AA0441#ASP] comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue with the alpha-amido of the following residue. subset: PSI-MOD-slim synonym: "(2-aminosuccinimidyl)acetic acid" EXACT RESID-name [] synonym: "(3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid" EXACT RESID-alternate [] synonym: "[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid" EXACT RESID-systematic [] synonym: "anhydroaspartyl glycine" EXACT RESID-alternate [] synonym: "aspartimide glycine" EXACT RESID-alternate [] synonym: "CROSSLNK (2-aminosuccinimidyl)acetic acid (Asp-Gly)" EXACT UniProt-feature [] synonym: "N-(2-aminosuccinyl)glycine" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 6 N 2 O 3" xref: MassAvg: "154.13" xref: MassMono: "154.037842" xref: Origin: "D, G" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01628 ! (2-aminosuccinimidyl)acetic acid [Term] id: MOD:00953 name: O-(L-isoglutamyl)-L-serine (Glu-Ser) def: "A protein modification that effectively crosslinks an L-glutamic acid residue and an L-serine residue by an ester bond and releasing water to form O-(L-isoglutamyl)-L-serine." [DeltaMass:0, PubMed:19035375, RESID:AA0597#ESX] comment: Cross-link 2; From DeltaMass: with no citation. synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK isoglutamyl serine ester (Ser-Glu)" EXACT UniProt-feature [] synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate [] synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name [] synonym: "O-gamma-Glutamyl- (Crosslink to Serine)" EXACT DeltaMass-label [] synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 8 H 10 N 2 O 4" xref: MassAvg: "198.18" xref: MassMono: "198.064057" xref: Origin: "E, S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01977 ! O-(L-isoglutamyl)-L-serine [Term] id: MOD:00954 name: crosslinked residues with loss of water def: "A protein modification that crosslinks two residues with a covalent bond and the loss of water." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:00955 name: alaninohistidine (serine crosslinked to tele or pros nitrogen of histidine) def: "A protein modification that effectively crosslinks an L-serine residue and an L-histidine residue to release water and form tele- or pros-(2-amino-2-carboxyethyl)histidine." [DeltaMass:0] comment: Cross-link 2; From DeltaMass with no citation or formula: Average Mass: -18. The DeltaMass description "Serine crosslinked to theta or pi carbon of Histidine" is incorrect. The histidine ring nitrogens (not carbons) are designated tele or N-tau (not theta), and pros or N-pi [JSG]. synonym: "beta-alaninohistidine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 9 H 10 N 4 O 2" xref: MassAvg: "206.20" xref: MassMono: "206.080376" xref: Origin: "H, S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:00916 ! modified L-serine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:00956 name: misincorporation of norleucine for methionine def: "modification from DeltaMass" [DeltaMass:10] comment: From DeltaMass: Average Mass: -18 Average Mass Change:-18 Notes: It has the same mass as leucine or isoleucine and can be charged on the methionyl t-RNA. This often happens in minimal media-prepared fermentations that are not supplemented with enough free methionine. It gives a mass change of -18 and can often be confused with dehydration. xref: DiffAvg: "-18.03" xref: DiffFormula: "C 1 H 2 N 0 O 0 S -1" xref: DiffMono: "-17.956421" xref: Formula: "C 6 H 11 N 1 O 1" xref: MassAvg: "113.16" xref: MassMono: "113.084064" xref: Origin: "M" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01026 ! norleucine residue (Nle) [Term] id: MOD:00957 name: modified residue with neutral loss of carbon dioxide def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral carbon dioxide molecular fragment." [PubMed:18688235] synonym: "dCO2ModRes" EXACT PSI-MOD-label [] xref: DiffAvg: "-44.01" xref: DiffFormula: "C -1 H 0 N 0 O -2" xref: DiffMono: "-43.989829" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00431 ! modified residue with a secondary neutral loss [Term] id: MOD:00958 name: crosslink between Arg and His sidechains def: "modification from DeltaMass" [DeltaMass:0] comment: Cross-link 2; From DeltaMass: Average Mass: -5 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "H, R" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00959 name: 3,3',5,5'-TerTyr (Crosslink) def: "modification from DeltaMass" [DeltaMass:0] comment: Cross-link 4; From DeltaMass: Average Mass: -4 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "Y, Y, Y, Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues [Term] id: MOD:00960 name: decarboxylated residue def: "A protein modification that effectively replaces a carboxylic acid group with a hydrogen atom." [PubMed:18688235] xref: DiffAvg: "-44.01" xref: DiffFormula: "C -1 H 0 N 0 O -2" xref: DiffMono: "-43.989829" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:00961 name: reduction of disulfide crosslink in cystine to two cysteines def: "A protein modification that effectively reduces the disulfide bond of cystine to form two cysteine residues." [DeltaMass:333] comment: Cross-link 2; this modification destroys the cross-link. From DeltaMass: Treatment of cystine (cys-cys) by reducing agents such as dithiothreitol (DTT) or triscarboxyethylphosphine (TCEP) results in cleavage of the disulphide bond and reduction of the sulphur atom of each molecule to create cysteine. subset: PSI-MOD-slim xref: DiffAvg: "2.02" xref: DiffFormula: "C 0 H 2 N 0 O 0 S 0" xref: DiffMono: "2.015650" xref: Formula: "C 6 H 10 N 2 O 2 S 2" xref: MassAvg: "206.28" xref: MassMono: "206.018370" xref: Origin: "MOD:00034" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01473 ! hydrogenated residue relationship: derives_from MOD:00034 ! L-cystine (cross-link) [Term] id: MOD:00962 name: 2',3'-dihydrotryptophan def: "A protein modification that by reducing the indole ring system of tryptophan to indoline effectively converts an L-tryptophan residue to 2',3'-dihydrotryptophan." [DeltaMass:343, URL:http\://dx.doi.org/10.1016/S0040-4039(00)99113-5] comment: From DeltaMass: References:1. Pearson,D.A., Blanchette,M., Baker,M.L. and Guindon,C.A. (1989) Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking ofprotecting groups in peptide synthesis. Tetrahedron Lett., 30(21), 2739-2742 Notes: Reduction of indole double bond of Trp which occurs when triethylsilane (TES) is used as a scavenger and Trp is incorporated without protection of indole nitrogen [1]. This side reaction is likely to be accompanied by oxidation of indoline ring with formation of intensively colored peptide by-products. Triisopropylsilane (TIPS) does not give this side reaction. See structure at http://www.abrf.org/images/misc/dmass2.gif. [However, the pictured indoline structure is incorrect - JSG]. xref: DiffAvg: "2.02" xref: DiffFormula: "C 0 H 2 N 0 O 0 S 0" xref: DiffMono: "2.015650" xref: Formula: "C 11 H 12 N 2 O 1" xref: MassAvg: "188.23" xref: MassMono: "188.094963" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00918 ! modified L-tryptophan residue is_a: MOD:01473 ! hydrogenated residue [Term] id: MOD:00963 name: Oxidation of Trp to kynurenine def: "Modification from DeltaMass. OBSOLETE because redundant and identical to MOD:00462. Remap to MOD:00462." [DeltaMass:357] comment: From DeltaMass: Average Mass: 4 Monoisotopic Mass Change:3.995 Average Mass Change:3.989 References:Ruoppolo M, Amoresano A, Pucci P, Pascarella S, Polticelli F, Trovato M,Menegatti E, Ascenzi P.Characterization of five new low-molecular-mass trypsin inhibitors fromwhite mustard (Sinapis alba L.) seed.Eur J Biochem. 2000 267:6486-92. Notes: See structure at http://www.abrf.org/images/misc/dmass32.jpg. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00964 name: lysine epsilon amino to imine + 12 amu def: "modification from DeltaMass" [DeltaMass:34] comment: From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Mathews, W. Rodney; Runge, Thomas A.; Haroldsen, Peter E.; Gaskell, Simon J. (1989) Characterization of impurities in a synthetic renin substrate peptide by fast-atom bombardment mass spectrometry and hybrid tandem mass spectrometry. Rapid Commun. Mass Spectrom. 3(9), 314-19 Notes: Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side products, including a component 12 Da higher in mass. Low-energy collisionally activated ***decompn*** analyses were performed using a hybrid tandem instrument and demonstrated that the heavier side product had two components, in which the structural modification was either at the N- or the C-terminus. Addnl. analyses of the N-acetyl deriv. indicated that for each component the structural modification blocked a site of N-acetylation. It is suggested that the formation of these side products is attributable to the generation of formaldehyde, during removal of the histidine protecting group (benzyloxymethyl), which reacts with the N-terminus of the peptide to give an imidazolidinone structure or with the D- ***lysine***.epsilon.-amine group to yield an ***imine*** . While the precise genesis of the side-products remains speculative, it is clear that the combined strategy of derivatization and tandem mass spectrometry has allowed structural conclusions concerning individual components of an isobaric mixt. synonym: "N6-(methylidene)-lysine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "12.01" xref: DiffFormula: "C 1 H 0 N 0 O 0" xref: DiffMono: "12.000000" xref: Formula: "C 7 H 12 N 2 O 1" xref: MassAvg: "140.19" xref: MassMono: "140.094963" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00965 name: 4-thiazolidinecarboxylic acid def: "A protein modification that effectively converts an N-terminal L-cysteine residue by a formadehyde adduct to 4-thiazolidinecarboxylic acid." [DeltaMass:342] comment: From DeltaMass: References: Mitchell, M.A., Runge, T.A., Mathews, W.R., Ichhpurani, A.K., Harn, N.K., Dobrowolski, P.J. and Eckenrrrode, F.M. Problems associated with use of the benzylozymethyl protecting group for histidines. Formaldehyde adducts formed during cleavage by hydrogen fluoride. Int. J. Pept. Protein Res. 1990, 36(4), 350-355. Gesquiere, J.-C., Diesis, E. and Tartar, A. Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deprotection of peptides containing pi-N-Bom protected histidine. J. Chem. Soc. Chem. Commun. 1990, (20), 1402-1403. Kumagaye, K.Y., Inui, T., Nakajima, K., Kimura,T. and Sakakibara, S. Suppression of a side reaction associated with Nim-benzyloxymethyl group during synthesis of peptides containing cysteinyl residue at the N-terminus. Pept. Res. 1991, 4(2), 84-87. Colombo, R., Colombo, F. and Jones, J.H. Acid-labile histidine side-chain protection. The N(pi)-t-butoxymethyl group. J. Chem. Soc. Chem. Commun. 1984, (5), 292-293. Notes: Conversion of N-term Cys to thiazolidine during HF deprotection of His(Bom)-containing peptides [1-3]. See structure at http://www.abrf.org/images/misc/dmass12b.gif; modification in red. This modification cannot be excluded during final deprotection/cleavage in Fmoc-chemistry in cases when His(Bum) was employed [4]. For formation of free imino acid see PubMed:1527501. synonym: "thioproline" EXACT DeltaMass-label [] xref: DiffAvg: "12.01" xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0" xref: DiffMono: "12.000000" xref: Formula: "C 4 H 6 N 1 O 1 S 1" xref: MassAvg: "116.16" xref: MassMono: "116.017010" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:00966 name: 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid def: "A protein modification that effectively converts an N-terminal L-tryptophan residue by a formadehyde adduct to 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid." [DeltaMass:339] comment: From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Lippke, K. P., W. G. Schunack, W. Wenning, W. E. Mueller. 1983..beta.-Carbolines as benzodiazepine receptor ligands. 1. Synthesis andbenzodiazepine receptor interaction of esters of.beta.-carboline-3-carboxylic acid. J. Med. Chem.26: 499-503 Cain, M., R. W. Weber, F. Guzman, J. M. Cook, S. A. Barker, K. C.Rice, J. N. Crawley, S. M. Paul, P. Skolnick. 1982. .beta.-Carbolines:synthesis and neurochemical and pharmacological actions on brainbenzodiazepine receptors.J. Med. Chem. 25: 1081-91 Notes: +12 Da modification corresponds to formaldehyde adduct of Trp having beta-carboline structure (methylene bridge links carbon-2 of indole ring and alfa-N. See structure at http://www.abrf.org/images/misc/dmass12a.gif; modification in red. xref: DiffAvg: "12.01" xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0" xref: DiffMono: "12.000000" xref: Formula: "C 12 H 10 N 2 O 1" xref: MassAvg: "198.22" xref: MassMono: "198.079313" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:00967 name: syndesine def: "A protein modification that effectively cross-links two L-lysine residues to form syndesine, hydroxylysinohydroxynorleucine." [DeltaMass:35, PubMed:75151974] comment: Cross-link 2; From DeltaMass: Average Mass: 13 Average Mass Change: 13 (incorrect) [JSG]. synonym: "hydroxylysinohydroxynorleucine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "16.96" xref: DiffFormula: "C 0 H -3 N -2 O 3" xref: DiffMono: "16.955121" xref: Formula: "C 12 H 21 N 2 O 5" xref: MassAvg: "273.31" xref: MassMono: "273.145047" xref: Origin: "K, K" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00968 name: CM-Cys vs PAM-Cys def: "modification from DeltaMass" [DeltaMass:347] comment: From DeltaMass: Average Mass: 13 Formula:C2H2O2 vs C3H5ON Monoisotopic Mass Change:13.03 Average Mass Change:13.05 Notes:Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetic acid e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxymethyl-Cys (CM-Cys, DeltaMass +58Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 13Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00969 name: CAM-Cys vs PAM-Cys def: "modification from DeltaMass" [DeltaMass:346] comment: From DeltaMass: Average Mass: 14 Formula:CH2 Monoisotopic Mass Change:14.016 Average Mass Change:14.027 Notes: Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetamide e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxamidomethyl-Cys (CAM-Cys, DeltaMass +57Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 14Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00970 name: delta-hydroxy-allysine (Lys) def: "modification from DeltaMass" [DeltaMass:37] comment: From DeltaMass: Average Mass: 15 Average Mass Change:15 Notes:In going from Lys to hydroxy-allysine, two separate reactions are involved:1. the oxidative deamination converting Lys to allysine (-CH2NH2 being converted to -CHO) with a net mass change of -1;2.conversion of allysine to delta-hydroxy-allysine (-CH2-CHO being converted to -CH(OH)-CHO) with a mass change of +16. The net change from Lys to hydroxyallysine thus is +15. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00971 name: Oxohistidine (from histidine) def: "modification from DeltaMass" [DeltaMass:38] comment: From DeltaMass: Average Mass: 16 Average Mass Change:16 References:Lewisch, S. A. and Levine, R. L. (1995) Anal. Biochem. 231, 440-446. Determination of 2-oxo-histidine by amino acid analysis Notes:Rod LevineNIHBldg 3, Room 106 MSC 0320Bethesda, MD 20892-0320email: rlevine@nih.govvoice: 1 (301) 496-2310fax: 1 (301) 496-0599 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "H" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00972 name: monobrominated L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to a monobrominated L-phenylalanine, such as L-2'-bromophenylalanine." [UniMod:340#F] comment: From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa synonym: "Br1Phe" EXACT PSI-MOD-label [] synonym: "bromination" RELATED UniMod-description [] synonym: "Bromo" RELATED PSI-MS-label [] xref: DiffAvg: "78.90" xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" xref: DiffMono: "77.910512" xref: Formula: "Br 1 C 9 H 8 N 1 O 1" xref: MassAvg: "226.07" xref: MassMono: "224.978926" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01066 ! halogenated phenylalanine is_a: MOD:01912 ! monobrominated residue [Term] id: MOD:00973 name: Oxidation of proline (to glutamic acid) def: "modification from DeltaMass" [DeltaMass:355] comment: From DeltaMass: Average Mass: 32 Monoisotopic Mass Change:31.99 Average Mass Change:32 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Rod Levine (unpublished) xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00974 name: (35)Cl labeled 3'-chlorotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 34 xref: DiffAvg: "33.96" xref: DiffFormula: "(35)Cl 1 H -1" xref: DiffMono: "33.961028" xref: Formula: "C 9 (35)Cl 1 H 8 N 1 O 2" xref: MassAvg: "197.02" xref: MassMono: "197.024356" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01046 ! 3'-chloro-L-tyrosine [Term] id: MOD:00975 name: (37)Cl labeled 3'-chlorotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 36 xref: DiffAvg: "35.96" xref: DiffFormula: "(37)Cl 1 H -1" xref: DiffMono: "35.958078" xref: Formula: "C 9 (37)Cl 1 H 8 N 1 O 2" xref: MassAvg: "199.02" xref: MassMono: "199.021406" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01046 ! 3'-chloro-L-tyrosine [Term] id: MOD:00976 name: potassium salt def: "modification from DeltaMass - OBSOLETE because redundant and identical to MOD:01072. Remap to MOD:01072." [DeltaMass:0] comment: From DeltaMass: Average Mass: 38 xref: DiffAvg: "38.09" xref: DiffFormula: "H -1 K 1" xref: DiffMono: "37.955882" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00977 name: disodium salt def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 44 subset: PSI-MOD-slim xref: DiffAvg: "43.96" xref: DiffFormula: "H -2 Na 2" xref: DiffMono: "43.963888" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00747 ! sodium containing modified residue [Term] id: MOD:00978 name: piperidine adduct to C-terminal Cys def: "modification from DeltaMass" [DeltaMass:345] comment: From DeltaMass: Average Mass: 51 Average Mass Change: 51 References:Lukszo, Patterson, Albericio, and Kates, Letters in Peptide Science 3, 157-166(1996) Notes:The side reaction can be very significant, and the level to which it occurs depends on how the C-terminal Cys is anchored and what the side-chain protecting group is. The mechanism involves piperidine-mediated beta-elimination of sulfur (with the protecting group on), followed by addition of piperidine across the C-terminaldehydroalanine. Since this last-mentioned step creates a chiral center, a mixture of diastereomers is formed which in special cases can be separatedby HPLC. Another problem with C-terminal Cys is racemization; some references in the review article by Andreu, Albericio, Sole, Munson, Ferrer, and Barany in Pennington-Dunn Peptide Synthesis and Purification Protocols, vol 35, 1994, pp. 91-169. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00979 name: t-butyl ester (OtBu) and t-butyl (tBu) def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 56 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00980 name: Carboxamidomethyl (on Cysteine) def: "modification from DeltaMass - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060." [DeltaMass:337] comment: From DeltaMass: Average Mass: 57 Abbreviation:CamCys Formula:C2H3NO Monoisotopic Mass Change:57.021 Average Mass Change:57.051 Notes:Cysteine reacts with iodoacetamide to produce carboxamidomethyl cysteine. Alternative names are often used, such as amidocarboxymethylcysteine and carbamoylmethylcysteine xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00981 name: sodium and potassium salt def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 60 subset: PSI-MOD-slim xref: DiffAvg: "60.07" xref: DiffFormula: "H -2 K 1 Na 1" xref: DiffMono: "59.937826" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00747 ! sodium containing modified residue is_a: MOD:00849 ! potassium containing modified residue [Term] id: MOD:00982 name: L-selenocysteine (Ser) def: "A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process)." [DeltaMass:0] comment: [From DeltaMass: Average Mass: 64.] Although selenocysteine-charged tRNA(Sec) is biosynthesized from serine-charged tRNA(Sec), in peptide work selenocysteine is usually considered as either a natural residue or as a modified cysteine residue. This entry is for the artifactual formation of L-selenocysteine from serine. For encoded L-selenocysteine, use MOD:00031 [JSG]. synonym: "Sec(Ser)" EXACT PSI-MOD-label [] synonym: "Selenocysteine (from Serine)" EXACT DeltaMass-label [] xref: DiffAvg: "62.97" xref: DiffFormula: "C 0 H 0 N 0 O -1 Se 1" xref: DiffMono: "63.921607" xref: Formula: "C 3 H 5 N 1 O 1 Se 1" xref: MassAvg: "150.05" xref: MassMono: "150.953635" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00031 ! L-selenocysteine residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:00983 name: Asp transamidation with piperidine def: "modification from DeltaMass" [DeltaMass:67] comment: From DeltaMass: Average Mass: 67 Average Mass Change:67 References:http://www.abrf.org/archives/hmail/0008/0007.html Notes:1.) Get rid of the DBU. It can cause piperidine amides at Asp residues. The tbu ester side chain comes off during synthesis and the residue is trans-amidated with piperidine (+67Da by MS). If you haven't yet seen this, you will. Even "normal" 20% pip/DMF (NMP) will cause this, but less frequently. Literature exists for this; I don't remember the exact reference. David H. Singleton Scientist Pfizer Central Research PO Box 8118-101 Eastern Point Road Groton, CT 06340 (860)441-4404. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00984 name: (35)Cl labeled 3',5'-dichlorotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 68 xref: DiffAvg: "67.92" xref: DiffFormula: "(35)Cl 2 H -2" xref: DiffMono: "67.922055" xref: Formula: "C 9 (35)Cl 2 H 7 N 1 O 2" xref: MassAvg: "230.99" xref: MassMono: "230.985384" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01045 ! 3',5'-dichloro-L-tyrosine [Term] id: MOD:00985 name: halogenated tyrosine def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a halogen atom." [PubMed:18688235] subset: PSI-MOD-slim synonym: "HalTyr" EXACT PSI-MOD-label [] xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:00986 name: (35)Cl and (37)Cl labeled 3',5'-dichlorotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 70. xref: DiffAvg: "69.92" xref: DiffFormula: "(35)Cl 1 (37)Cl 1 H -2" xref: DiffMono: "69.919105" xref: Formula: "C 9 (35)Cl 1 (37)Cl 1 H 7 N 1 O 2" xref: MassAvg: "232.98" xref: MassMono: "232.982434" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01045 ! 3',5'-dichloro-L-tyrosine [Term] id: MOD:00987 name: chlorinated tyrosine def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a chlorine atom." [PubMed:18688235] synonym: "ClTyr" EXACT PSI-MOD-label [] xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00753 ! chlorinated residue is_a: MOD:00985 ! halogenated tyrosine [Term] id: MOD:00988 name: brominated tyrosine def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a bromine atom." [PubMed:18688235] synonym: "BrTyr" EXACT PSI-MOD-label [] xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00754 ! brominated residue is_a: MOD:00985 ! halogenated tyrosine [Term] id: MOD:00989 name: acetamidomethyl (Acm) def: "OBSOLETE because redundant, the difference component of MOD:01079. Remap to MOD:01079." [DeltaMass:0] comment: From DeltaMass with no citation or formula. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:00990 name: (37)Cl labeled 3',5'-dichlorotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 72 xref: DiffAvg: "71.92" xref: DiffFormula: "(37)Cl 2 H -2" xref: DiffMono: "71.916155" xref: Formula: "C 9 (37)Cl 2 H 7 N 1 O 2" xref: MassAvg: "234.98" xref: MassMono: "234.979484" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01045 ! 3',5'-dichloro-L-tyrosine [Term] id: MOD:00991 name: S-(sn-1-glyceryl)-L-cysteine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 74 with no citation. xref: DiffAvg: "74.08" xref: DiffFormula: "C 3 H 6 O 2" xref: DiffMono: "74.036779" xref: Formula: "C 6 H 11 N 1 O 3 S 1" xref: MassAvg: "177.22" xref: MassMono: "177.045964" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:00992 name: glutamate 5-glycerol ester def: "modification from DeltaMass" [DeltaMass:78, PubMed:18767873] comment: From DeltaMass: Average Mass: 74 Average Mass Change: 74 References: Anal. Biochem. 1993 Vol 208 No. 2 382-386, PubMed:8452236. [DeltaMass] This article only suggests this as a possible modification and does no characterization. Isolation and stuctural evidence for artifactual modification are found in PubMed:18767873 [JSG]. xref: DiffAvg: "74.08" xref: DiffFormula: "C 3 H 6 O 2" xref: DiffMono: "74.036779" xref: Formula: "C 8 H 13 N 1 O 5" xref: MassAvg: "203.19" xref: MassMono: "203.079373" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:00993 name: phenyl ester def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 76, on acidic amino acids synonym: "OPh" EXACT DeltaMass-label [] xref: DiffAvg: "76.10" xref: DiffFormula: "C 6 H 4" xref: DiffMono: "76.031300" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00994 name: (79)Br labeled 3'-bromotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 78 xref: DiffAvg: "77.91" xref: DiffFormula: "(79)Br 1 H -1" xref: DiffMono: "77.910512" xref: Formula: "(79)Br 1 C 9 H 8 N 1 O 2" xref: MassAvg: "240.97" xref: MassMono: "240.973841" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01025 ! 3'-bromo-L-tyrosine [Term] id: MOD:00995 name: (81)Br labeled 2'-bromophenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to (81)Br-L-2'-bromophenylalanine." [DeltaMass:0] comment: From DeltaMass: Average Mass: 80 xref: DiffAvg: "79.91" xref: DiffFormula: "(81)Br 1 H -1" xref: DiffMono: "79.908466" xref: Formula: "(81)Br 1 C 9 H 8 N 1 O 1" xref: MassAvg: "226.98" xref: MassMono: "226.976879" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00183 ! L-2'-bromophenylalanine [Term] id: MOD:00996 name: (81)Br labeled 3'-bromotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 80 xref: DiffAvg: "79.91" xref: DiffFormula: "(81)Br 1 H -1" xref: DiffMono: "79.908466" xref: Formula: "(81)Br 1 C 9 H 8 N 1 O 2" xref: MassAvg: "242.97" xref: MassMono: "242.971794" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01025 ! 3'-bromo-L-tyrosine [Term] id: MOD:00997 name: cyclohexyl ester def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 82 synonym: "OcHex" EXACT DeltaMass-label [] xref: DiffAvg: "82.15" xref: DiffFormula: "C 6 H 10" xref: DiffMono: "82.078250" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:00998 name: iodinated tyrosine def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with an iodine atom." [PubMed:18688235] subset: PSI-MOD-slim synonym: "ITyr" EXACT PSI-MOD-label [] xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00755 ! iodinated residue is_a: MOD:00985 ! halogenated tyrosine [Term] id: MOD:00999 name: homoseryl lactone def: "OBSOLETE because redundant and identical to MOD:00404. Remap to MOD:00404." [DeltaMass:90] comment: From DeltaMass: Average Mass: 83 Formula:C4H5O1N1 Monoisotopic Mass Change:83.037 Average Mass Change:83.09 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01000 name: monobrominated tyrosine def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one bromine atom." [PubMed:18688235] synonym: "Br1Tyr" EXACT PSI-MOD-label [] xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00988 ! brominated tyrosine [Term] id: MOD:01001 name: 2-aminoisobutyric acid residue (Aib) def: "A protein modification that inserts or replaces a residue with a 2-aminoisobutyric acid." [DeltaMass:0] comment: Modification from DeltaMass: Average Mass: 85. synonym: "2-amino-2-methylpropanoic acid" EXACT PSI-MOD-alternate [] synonym: "2-amino-2-methylpropionic acid" EXACT PSI-MOD-alternate [] synonym: "2-methylalanine" EXACT PSI-MOD-alternate [] synonym: "Aib" EXACT PSI-MOD-alternate [] synonym: "alpha,alpha-dimethylglycine" EXACT PSI-MOD-alternate [] synonym: "alpha-aminoisobutyric acid" EXACT PSI-MOD-alternate [] synonym: "alpha-methylalanine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 4 H 7 N 1 O 1" xref: MassAvg: "85.11" xref: MassMono: "85.052764" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00850 ! unnatural residue [Term] id: MOD:01002 name: gamma-aminobutyryl def: "modification from DeltaMass" [DeltaMass:92] comment: From DeltaMass: Average Mass: 85 Formula: C 4 H 7 O 1 N 1 Monoisotopic Mass Change: 85.053 Average Mass Change: 85.106 xref: DiffAvg: "85.11" xref: DiffFormula: "C 4 H 7 N 1 O 1" xref: DiffMono: "85.052764" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01003 name: t-butyloxymethyl (Bum) def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 86 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01004 name: diaminopropionyl def: "modification from DeltaMass" [DeltaMass:95] comment: From DeltaMass: Average Mass: 86 Formula: C 3 H 6 O 2 N 1 Monoisotopic Mass Change: 86.048 Average Mass Change: 86.094 xref: DiffAvg: "86.09" xref: DiffFormula: "C 3 H 6 N 2 O 1" xref: DiffMono: "86.048013" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01005 name: t-butylsulfenyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 88 synonym: "StBu" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01006 name: dibrominated tyrosine def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two bromine atoms." [UniMod:534] synonym: "Br2Tyr" EXACT PSI-MOD-label [] synonym: "Dibromo" RELATED PSI-MS-label [] synonym: "Dibromo" RELATED UniMod-description [] xref: DiffAvg: "157.79" xref: DiffFormula: "Br 2 C 0 H -2 N 0 O 0" xref: DiffMono: "155.821024" xref: Formula: "Br 2 C 9 H 7 N 1 O 2" xref: MassAvg: "320.97" xref: MassMono: "318.884353" xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00988 ! brominated tyrosine [Term] id: MOD:01007 name: anisyl modified residue def: "A protein modification that effectively substitutes an anisyl (methoxyphenyl) group for a hydroxyl group, typically at the 4 or para position." [DeltaMass:0] comment: From DeltaMass with no citation or formula: Average Mass: 90. xref: DiffAvg: "90.13" xref: DiffFormula: "C 7 H 6" xref: DiffMono: "90.046950" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01008 name: benzyl (Bzl) and benzyl ester (OBzl) modified residue def: "A protein modification that effectively substitutes a benzyl (phenylmethyl) group for a hydrogen atom." [DeltaMass:0] comment: From DeltaMass with no citation or formula: Average Mass: 90 xref: DiffAvg: "90.13" xref: DiffFormula: "C 7 H 6" xref: DiffMono: "90.046950" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01009 name: dehydrogenated proline def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass with no citation. xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 5 H 5 N 1 O 1" xref: MassAvg: "95.10" xref: MassMono: "95.037114" xref: Origin: "P" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01010 name: trifluoroacetylated residue def: "A protein modification that effectively substitutes a trifluoroacetyl group for a hydrogen atom." [DeltaMass:0] synonym: "TFA" EXACT DeltaMass-label [] xref: DiffAvg: "96.01" xref: DiffFormula: "C 2 F 3 H -1 O 1" xref: DiffMono: "95.982299" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00498 ! fluorinated residue is_a: MOD:00649 ! acylated residue is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01011 name: N-hydroxysuccinimide (ONSu, OSu) def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 97 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01012 name: oxidation of disulfide crosslink in cystine to two cysteic acids def: "A protein modification that effectively oxidizes the disulfide bond of a cystine crosslink to form two cysteic acid residues." [DeltaMass:335] comment: Cross-link 2. This modification destroys a cross-link. From DeltaMass: Average Mass: 98 Abbreviation: Cya Average Mass Change: 98 Notes: Treatment of cystine by strongly oxidising reagents such as performic acid results in the breakage of the disulphide bond and complete oxidation of the sulphur atoms on each molecule. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. xref: DiffAvg: "98.01" xref: DiffFormula: "C 0 H 2 N 0 O 6 S 0" xref: DiffMono: "97.985138" xref: Formula: "C 6 H 10 N 2 O 8 S 2" xref: MassAvg: "302.27" xref: MassMono: "301.987857" xref: Origin: "MOD:00034" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00460 ! L-cysteic acid (L-cysteine sulfonic acid) relationship: derives_from MOD:00034 ! L-cystine (cross-link) [Term] id: MOD:01013 name: tetramethylguanidinium termination by-product on amine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 98 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01014 name: phosphate/sulphate adduct of proteins def: "modification from DeltaMass" [DeltaMass:358] comment: From DeltaMass: Average Mass: 98 Formula:H3PO4 or H2SO4 Monoisotopic Mass Change:97.97 Average Mass Change:98 Notes:Proteins may pick up non-covalent salt adducts during purification. Phosphate and sulphate salts are commonly used and may be observed as +98 amu adducts (or multiples thereof) forming ion pairs with basic residues. Monoisotopic masses H2SO4 97.967, H3PO4 97.977 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01015 name: isovaline residue (Iva) def: "A protein modification that inserts or replaces a residue with an isovaline." [DeltaMass:110] synonym: "2-amino-2-methylbutanoic acid" EXACT PSI-MOD-alternate [] synonym: "Isovalyl (-I-,-Iva-)" EXACT DeltaMass-label [] synonym: "Iva" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 5 H 9 N 1 O 1" xref: MassAvg: "99.13" xref: MassMono: "99.068414" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00850 ! unnatural residue [Term] id: MOD:01016 name: t-butyloxycarbonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 100 synonym: "tBoc" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01017 name: homoseryl (-Hse-) def: "OBSOLETE because redundant and identical to MOD:00403. Remap to MOD:00403." [DeltaMass:113] comment: From DeltaMass: Average Mass: 101 Abbreviation:-Hse- Formula:C4H7O2N Monoisotopic Mass Change:101.048 Average Mass Change:101.105 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01018 name: 4-methylbenzyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 104 synonym: "Meb" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01019 name: hydroxymethylphenyl linker def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 106 synonym: "HMP" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01020 name: thioanisyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 106 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01021 name: thiocresyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 106 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01022 name: 2-piperidinecarboxylic acid def: "A protein modification that effectively converts an L-lysine residue to 2-piperidinecarboxylic acid." [DeltaMass:0] synonym: "Pip" EXACT DeltaMass-label [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 6 H 9 N 1 O 1" xref: MassAvg: "111.14" xref: MassMono: "111.068414" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00601 ! cyclized residue is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01160 ! deaminated residue [Term] id: MOD:01023 name: 3',5'-dibromo-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-dibromo-L-tyrosine." [DeltaMass:156] synonym: "3',5'-Br2Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "157.79" xref: DiffFormula: "Br 2 C 0 H -2 N 0 O 0" xref: DiffMono: "155.821024" xref: Formula: "Br 2 C 9 H 7 N 1 O 2" xref: MassAvg: "320.97" xref: MassMono: "318.884353" xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01006 ! dibrominated tyrosine [Term] id: MOD:01024 name: monohydroxylated proline def: "A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline." [DeltaMass:0, OMSSA:62, UniMod:35#P] comment: From DeltaMass: Average Mass: 131. This is the mass of the free amino acid [JSG]. subset: PSI-MOD-slim synonym: "Hy1Pro" EXACT PSI-MOD-label [] synonym: "hydroxylationp" EXACT OMSSA-label [] synonym: "Hydroxyproline" EXACT DeltaMass-label [] synonym: "Hyp" EXACT DeltaMass-label [] synonym: "Oxidation" RELATED PSI-MS-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 7 N 1 O 2" xref: MassAvg: "113.12" xref: MassMono: "113.047678" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00594 ! residues isobaric at 113.047678 Da is_a: MOD:00678 ! hydroxylated proline [Term] id: MOD:01025 name: 3'-bromo-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 3'-bromo-L-tyrosine." [PubMed:18688235] synonym: "3'-BrTyr" EXACT PSI-MOD-label [] xref: DiffAvg: "78.90" xref: DiffFormula: "Br 1 H -1" xref: DiffMono: "77.910512" xref: Formula: "Br 1 C 9 H 8 N 1 O 2" xref: MassAvg: "242.07" xref: MassMono: "240.973841" xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01000 ! monobrominated tyrosine [Term] id: MOD:01026 name: norleucine residue (Nle) def: "A protein modification that inserts or replaces a residue with a norleucine." [DeltaMass:126] synonym: "Nle" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 11 N 1 O 1" xref: MassAvg: "113.16" xref: MassMono: "113.084064" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00850 ! unnatural residue [Term] id: MOD:01027 name: t-amyloxycarbonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 114 synonym: "Aoc" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01028 name: monochlorinated L-tyrosine def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one chlorine atom." [PubMed:18688235] synonym: "Cl1Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "34.44" xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" xref: DiffMono: "33.961028" xref: Formula: "C 9 Cl 1 H 8 N 1 O 2" xref: MassAvg: "197.62" xref: MassMono: "197.024356" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00987 ! chlorinated tyrosine is_a: MOD:01911 ! monochlorinated residue [Term] id: MOD:01029 name: succinylated residue def: "A protein modification that effectively replaces a hydrogen atom with a succinyl group linked through a carbonyl carbon." [DeltaMass:0, UniMod:64] comment: From DeltaMass with no citation or formula, Average Mass: 117 [JSG]. subset: PSI-MOD-slim synonym: "Succinic anhydride labeling reagent light form (N-term & K)" RELATED UniMod-description [] xref: DiffAvg: "100.07" xref: DiffFormula: "C 4 H 4 O 3" xref: DiffMono: "100.016044" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue [Term] id: MOD:01030 name: hydroxybenzotriazole ester def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 117 synonym: "HOBt" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01031 name: dimethylbenzyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 118 synonym: "diMeBzl" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01032 name: benzyloxymethyl modified residue def: "A protein modification that effectively substitutes a benzyloxymethyl group for a hydrogen atom." [DeltaMass:0] synonym: "Bom" EXACT DeltaMass-label [] xref: DiffAvg: "120.15" xref: DiffFormula: "C 8 H 8 O 1" xref: DiffMono: "120.057515" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01033 name: p-methoxybenzyl modified residue def: "A protein modification that effectively substitutes a p-methoxybenzyl group for a hydrogen atom." [DeltaMass:0] synonym: "Mbzl" EXACT DeltaMass-label [] synonym: "Mob" EXACT DeltaMass-label [] xref: DiffAvg: "120.15" xref: DiffFormula: "C 8 H 8 O 1" xref: DiffMono: "120.057515" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01034 name: 4-nitrophenyl modified residue def: "A protein modification that effectively substitutes a 4-nitrophenyl group for a hydrogen atom." [DeltaMass:0] synonym: "ONp" EXACT DeltaMass-label [] synonym: "p-nitrophenyl" EXACT DeltaMass-label [] xref: DiffAvg: "121.10" xref: DiffFormula: "C 6 H 3 N 1 O 2" xref: DiffMono: "121.016378" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01035 name: chlorobenzyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 125 synonym: "ClBzl" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01036 name: O-methyl aspartyl def: "OBSOLETE because redundant and identical to MOD:01181. Remap to MOD:01181." [PubMed:18688235] comment: From DeltaMass:148 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 129 Formula: C5H7O1N3 Monoisotopic Mass Change: 129.042 Average Mass Change: 129.116 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "D" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01037 name: dichlorinated tyrosine def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two chlorine atoms." [PubMed:18688235] synonym: "Cl2Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "68.88" xref: DiffFormula: "C 0 Cl 2 H -2 N 0 O 0" xref: DiffMono: "67.922055" xref: Formula: "C 9 Cl 2 H 7 N 1 O 2" xref: MassAvg: "232.06" xref: MassMono: "230.985384" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00987 ! chlorinated tyrosine [Term] id: MOD:01038 name: norleucine (Nle) def: "OBSOLETE because this represents a free amino acid and the corresponding residue is MOD:01026." [DeltaMass:0] comment: From DeltaMass: Average Mass: 131. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01039 name: hydroxy aspartyl def: "OBSOLETE because redundant and identical to MOD:00036. Remap to MOD:00036." [PubMed:18688235] comment: From DeltaMass:152 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 131 Formula:C4H5O1N4 Monoisotopic Mass Change:131.022 Average Mass Change:131.088 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 4 H 5 N 1 O 4" xref: MassAvg: "131.09" xref: MassMono: "131.021858" xref: Origin: "D" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01040 name: penicillamine residue def: "A protein modification that inserts or replaces a residue with a penicillamine." [DeltaMass:154] comment: From DeltaMass: Name misspelled 'bb-dimethyl cystenyl'. No citation provided. synonym: "2-amino-3-mercapto-3-methylbutanoic acid" EXACT PSI-MOD-alternate [] synonym: "2-amino-3-methyl-3-sulfanylbutanoic acid" EXACT PSI-MOD-alternate [] synonym: "3,3-dimethylcysteine" EXACT PSI-MOD-alternate [] synonym: "3-mercapto-L-valine" EXACT PSI-MOD-alternate [] synonym: "beta,beta-dimethylcysteine" EXACT DeltaMass-label [] synonym: "Pen" EXACT DeltaMass-label [] synonym: "Pen" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 5 H 9 N 1 O 1 S 1" xref: MassAvg: "131.19" xref: MassMono: "131.040485" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00850 ! unnatural residue [Term] id: MOD:01041 name: benzyloxycarbonyl modified residue def: "A protein modification that effectively substitutes a benzyloxycarbonyl group for a hydrogen atom." [DeltaMass:0] synonym: "Z" EXACT DeltaMass-label [] xref: DiffAvg: "134.13" xref: DiffFormula: "C 8 H 6 O 2" xref: DiffMono: "134.036779" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01042 name: adamantyl modified residue def: "A protein modification that effectively substitutes a adamantyl group for a hydrogen atom." [DeltaMass:0] synonym: "Ada" EXACT DeltaMass-label [] xref: DiffAvg: "134.22" xref: DiffFormula: "C 10 H 14" xref: DiffMono: "134.109550" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01043 name: p-nitrobenzyl ester modified residue def: "A protein modification that effectively substitutes a p-nitrobenzyl group for the hydrogen atom of a carboxyl group." [DeltaMass:0] synonym: "ONb" EXACT DeltaMass-label [] xref: DiffAvg: "135.12" xref: DiffFormula: "C 7 H 5 N 1 O 2" xref: DiffMono: "135.032028" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01044 name: N-methyl glutamyl def: "OBSOLETE because redundant and identical to MOD:00080. Remap to MOD:00080." [DeltaMass:166] comment: From DeltaMass with no citation. Formula:C6H10O2N2 (name misspelled, formula for N5-methylglutaminyl, rather than N2-methylglutamyl) xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "Q" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01045 name: 3',5'-dichloro-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-dichloro-L-tyrosine." [PubMed:18688235] synonym: "3',5'-Cl2Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "68.88" xref: DiffFormula: "C 0 Cl 2 H -2 N 0 O 0" xref: DiffMono: "67.922055" xref: Formula: "C 9 Cl 2 H 7 N 1 O 2" xref: MassAvg: "232.06" xref: MassMono: "230.985384" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01037 ! dichlorinated tyrosine [Term] id: MOD:01046 name: 3'-chloro-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 3'-chloro-L-tyrosine." [PubMed:18688235] synonym: "3'-ClTyr" EXACT PSI-MOD-label [] xref: DiffAvg: "34.44" xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" xref: DiffMono: "33.961028" xref: Formula: "C 9 Cl 1 H 8 N 1 O 2" xref: MassAvg: "197.62" xref: MassMono: "197.024356" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01028 ! monochlorinated L-tyrosine [Term] id: MOD:01047 name: monohydroxylated lysine def: "A protein modification that effectively converts an L-lysine residue to a monohydroxylated lysine." [DeltaMass:168, OMSSA:60, UniMod:35#K] comment: From DeltaMass: Average Mass: 144 Abbreviation:-Hyl- Formula:C6H12N2O2 Monoisotopic Mass Change:144.09 Average Mass Change:144.174. subset: PSI-MOD-slim synonym: "Hy1Lys" EXACT PSI-MOD-label [] synonym: "Hydroxy Lysyl (-Hyl-)" EXACT DeltaMass-label [] synonym: "hydroxylationk" EXACT OMSSA-label [] synonym: "Oxidation" RELATED PSI-MS-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 12 N 2 O 2" xref: MassAvg: "144.17" xref: MassMono: "144.089878" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00681 ! hydroxylated lysine [Term] id: MOD:01048 name: 2-pyrrolidone-5-carboxylic acid def: "A protein modification that effectively converts a source amino acid residue to 2-pyrrolidone-5-carboxylic acid." [PubMed:18688235] comment: From DeltaMass: Average Mass: -18 Average Mass Change: -18.01 References:The conversion of glutamic acid to pyroglutamic was reported for the beta-amiloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52. subset: PSI-MOD-slim synonym: "PyrGlu" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 5 H 6 N 1 O 2" xref: MassAvg: "112.11" xref: MassMono: "112.039853" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "N-term" is_a: MOD:00601 ! cyclized residue is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01049 name: halogenated histidine def: "A protein modification that effectively substitutes a hydrogen atom of an L-histidine residue with a halogen atom." [PubMed:18688235] synonym: "HalHis" EXACT PSI-MOD-label [] xref: Origin: "H" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01050 name: pyridyl alanyl def: "modification from DeltaMass" [DeltaMass:180] comment: From DeltaMass: Average Mass: 148 Formula:C8H8O2N1 Monoisotopic Mass Change:148.064 Average Mass Change:148.165 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "A" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01051 name: 2-nitrobenzoyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 149 synonym: "NBz" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01052 name: dimethoxybenzyl Trp def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 150 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01053 name: 2-nitrophenylsulphenyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 153 synonym: "Nps" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01054 name: 4-toluenesulfonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 154 synonym: "4-toluenesulphonyl" EXACT DeltaMass-label [] synonym: "Tos" EXACT DeltaMass-label [] synonym: "Tosyl" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01055 name: 3-nitro-2-pyridinesulfenyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 154 synonym: "Npys" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01056 name: (79)Br labeled 3',5'-dibromotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 156 xref: DiffAvg: "155.82" xref: DiffFormula: "(79)Br 2 C 0 H -2 N 0 O 0" xref: DiffMono: "155.821024" xref: Formula: "(79)Br 2 C 9 H 7 N 1 O 2" xref: MassAvg: "318.88" xref: MassMono: "318.884353" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01023 ! 3',5'-dibromo-L-tyrosine [Term] id: MOD:01057 name: (79)Br and (81)Br labeled 3',5'-dibromotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 158 xref: DiffAvg: "157.82" xref: DiffFormula: "(79)Br 1 (81)Br 1 C 0 H -2 N 0 O 0" xref: DiffMono: "157.818978" xref: Formula: "(79)Br 1 (81)Br 1 C 9 H 7 N 1 O 2" xref: MassAvg: "320.88" xref: MassMono: "320.882306" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01023 ! 3',5'-dibromo-L-tyrosine [Term] id: MOD:01058 name: dichlorobenzyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 159 synonym: "Dcb" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01059 name: (81)Br labeled 3',5'-dibromotyrosine def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 160 xref: DiffAvg: "159.82" xref: DiffFormula: "(81)Br 2 C 0 H -2 N 0 O 0" xref: DiffMono: "159.816931" xref: Formula: "(81)Br 2 C 9 H 7 N 1 O 2" xref: MassAvg: "322.88" xref: MassMono: "322.880260" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01023 ! 3',5'-dibromo-L-tyrosine [Term] id: MOD:01060 name: S-carboxamidomethyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine." [DeltaMass:196, DeltaMass:337, OMSSA:3, PubMed:10504701, PubMed:11510821, PubMed:12422359, PubMed:18306178, UniMod:4#C] comment: From DeltaMass: (name misspelled "Carboxyamidomethyl Cystenyl") [JSG]. subset: PSI-MOD-slim synonym: "amidocarboxymethylcysteine" EXACT DeltaMass-label [] synonym: "CamC" EXACT PSI-MOD-alternate [] synonym: "CamCys" EXACT DeltaMass-label [] synonym: "Carbamidomethyl" RELATED PSI-MS-label [] synonym: "carbamidomethylc" EXACT OMSSA-label [] synonym: "carbamoylmethylcysteine" EXACT DeltaMass-label [] synonym: "Carboxamidomethyl (on Cysteine)" EXACT DeltaMass-label [] synonym: "Carboxyamidomethyl Cystenyl" EXACT DeltaMass-label [] synonym: "Iodoacetamide derivative" RELATED UniMod-description [] synonym: "S-carbamoylmethyl-L-cysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1 S 0" xref: DiffMono: "57.021464" xref: Formula: "C 5 H 8 N 2 O 2 S 1" xref: MassAvg: "160.19" xref: MassMono: "160.030649" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01061 name: S-carboxymethyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine." [DeltaMass:0, DeltaMass:197, OMSSA:2, UniMod:6#C] comment: From DeltaMass with no citation, name misspelled "Carboxymethyl Cystenyl", and formula incorrect, N and O reversed: Average Mass: 161 Abbreviation: -Cmc- Formula: C5H7O1N3S1 Monoisotopic Mass Change: 161.015 Average Mass Change: 161.179 [JSG]. subset: PSI-MOD-slim synonym: "Carboxymethyl" RELATED PSI-MS-label [] synonym: "Carboxymethyl cysteine" EXACT DeltaMass-label [] synonym: "Carboxymethyl Cystenyl" EXACT DeltaMass-label [] synonym: "carboxymethylc" EXACT OMSSA-label [] synonym: "CmC" EXACT PSI-MOD-alternate [] synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 N 0 O 2 S 0" xref: DiffMono: "58.005479" xref: Formula: "C 5 H 7 N 1 O 3 S 1" xref: MassAvg: "161.18" xref: MassMono: "161.014664" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00399 ! iodoacetic acid derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01062 name: carboxymethyl cysteinyl def: "OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061" [DeltaMass:197] comment: From DeltaMass:197 (Name misspelled "cystenyl", and formula incorrect, N and O reversed) Abbreviation:-Cmc- Formula:C5H7O1N3S1 Monoisotopic Mass Change:161.015 Average Mass Change:161.179 synonym: "Carboxymethyl Cystenyl" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 5 H 7 N 3 O 1 S 1" xref: MassAvg: "157.19" xref: MassMono: "157.030983" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01063 name: monomethylated phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to a monomethylated phenylalanine." [DeltaMass:198] comment: From DeltaMass: Average Mass: 161 Formula: C10H11O1N1 Monoisotopic Mass Change: 161.084 Average Mass Change: 161.205. No citation provided. It is not obvious whether the DeltaMass entry is supposed to represent N-methylphenylalanine, alpha-methylphenylalanine, 2'-, 3'-, or 4'-methylphenylalanine [JSG]. subset: PSI-MOD-slim synonym: "NMePhe" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 10 H 11 N 1 O 1" xref: MassAvg: "161.20" xref: MassMono: "161.084064" xref: Origin: "F" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00717 ! methylated phenylalanine [Term] id: MOD:01064 name: inositol def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 162 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01065 name: hexose glycated N-terminal def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein N-terminal amino group to form a Schiff-base or an Amadori ketosamine (or aminoketose) residue adduct." [DeltaMass:0, UniMod:41#N-term] comment: From DeltaMass: Average Mass: 162 xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 O 5" xref: DiffMono: "162.052823" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "N-term" is_a: MOD:00767 ! glycated residue [Term] id: MOD:01066 name: halogenated phenylalanine def: "A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a halogen atom." [PubMed:18688235] synonym: "HalPhe" EXACT PSI-MOD-label [] xref: Origin: "F" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:01067 name: linker attached to peptide in Fmoc peptide synthesis def: "modification from DeltaMass" [DeltaMass:341] comment: From DeltaMass: Average Mass: 162 Average Mass Change:162 Notes: (from the ABRF discussion list archive) There may be ... things in the reagent K that would allow cleavage of the peptide to occur at the wrong place...in this case it removes the dimethoxybenzyl group first inactivating that site for cleavage, and it goes after tne next amide bond closer to the resin. Try the TFA/TIS/water/EDT cocktail...TFA = 92%, TIS =3%, and water is at 5%. .. had this issue on longer peptides.. and by increasing the amount of water a little bit... able to elminate this problem. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01068 name: halogenated tryptophan def: "A protein modification that effectively substitutes a hydrogen atom of an L-tryptophan residue with a halogen atom." [PubMed:18688235] synonym: "HalTrp" EXACT PSI-MOD-label [] xref: Origin: "W" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01069 name: 2,4-dinitrophenyl modified residue def: "A protein modification that effectively substitutes a 2,4-dinitrophenyl group for a hydrogen atom." [DeltaMass:0] synonym: "Dnp" EXACT DeltaMass-label [] xref: DiffAvg: "166.09" xref: DiffFormula: "C 6 H 2 N 2 O 4" xref: DiffMono: "166.001457" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01070 name: pentafluorophenyl modified residue def: "A protein modification that effectively substitutes a pentafluorophenyl group for a hydrogen atom." [DeltaMass:0] comment: From DeltaMass: name mispelled "pentaflourophenyl" synonym: "Pfp" EXACT DeltaMass-label [] xref: DiffAvg: "166.05" xref: DiffFormula: "C 6 F 5 H -1" xref: DiffMono: "165.984191" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01071 name: diphenylmethyl modified residue def: "A protein modification that effectively substitutes a diphenylmethyl group for a hydrogen atom." [DeltaMass:0] synonym: "Dpm" EXACT DeltaMass-label [] xref: DiffAvg: "166.22" xref: DiffFormula: "C 13 H 10" xref: DiffMono: "166.078250" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01072 name: monopotassium salt def: "A protein modification that effectively substitutes one potassium atom for one hydrogen atom." [DeltaMass:0] subset: PSI-MOD-slim synonym: "K1Res" EXACT PSI-MOD-label [] xref: DiffAvg: "38.09" xref: DiffFormula: "H -1 K 1" xref: DiffMono: "37.955882" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00849 ! potassium containing modified residue [Term] id: MOD:01073 name: 2-chlorobenzyloxycarbonyl modified residue def: "A protein modification that effectively substitutes a 2-chlorobenzyloxycarbonyl group for a hydrogen atom." [DeltaMass:0] synonym: "Clz" EXACT DeltaMass-label [] xref: DiffAvg: "169.58" xref: DiffFormula: "C 8 Cl 1 H 6 O 2" xref: DiffMono: "169.005632" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01074 name: napthylacetyl modified residue def: "A protein modification that effectively substitutes a napthylacetyl group for a hydrogen atom." [DeltaMass:0] xref: DiffAvg: "169.20" xref: DiffFormula: "C 12 H 9 O 1" xref: DiffMono: "169.065340" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01075 name: mercury containing modified residue def: "A protein modification that effectively substitutes a mercury atom or a cluster containing mercury for hydrogen atoms, or that coordinates a mercury ion." [PubMed:18688235] synonym: "HgRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:01076 name: N-methyl arginyl def: "modification from DeltaMass - OBSOLETE because redundant and identical to MOD:00414. Remap to MOD:00414." [DeltaMass:215] comment: From DeltaMass: Average Mass: 170 Formula:C7H14O4N1 Monoisotopic Mass Change:170.117 Average Mass Change:170.215 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 7 H 14 N 4 O 1" xref: MassAvg: "170.22" xref: MassMono: "170.116761" xref: Origin: "R" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01077 name: ethanedithiol/TFA cyclic adduct def: "modification from DeltaMass" [DeltaMass:216] comment: From DeltaMass: Average Mass: 172 Average Mass Change:172 References:[1]. Sieber,P.(1987) Modification of tryptophan residues during acidolysis of4-methoxy-2,3,6-trimethylbenzenesulfonyl groups. Effects of scavengers. Tetrahedron Lett., 28(15),1637-1640. Notes: TFA-cyclic dithioketal by-product is formed when Trp-containing peptide is subjected to prolonged TFA/EDT treatment [1]. See structure at http://www.abrf.org/images/misc/dmass172.gif. Additional discussion of this adduct, and how to avoid it, can befound in Methods in Enzymology 289, 67 (1997) xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01078 name: S-(2-aminoethyl)-3-methylcysteine (Thr) def: "A protein modification that effectively converts an L-threonine residue to S-(2-aminoethyl)-3-methylcysteine." [PubMed:12923550, UniMod:472#T] comment: From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. synonym: "2-amino-3-(2-aminoethyl)sulfanyl-3-methylbutanoic acid" EXACT PSI-MOD-alternate [] synonym: "AEC-MAEC" RELATED UniMod-interim [] synonym: "beta-methylaminoethylcysteine" RELATED UniMod-description [] synonym: "S-aminoethyl-3-methylcysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "59.13" xref: DiffFormula: "C 2 H 5 N 1 O -1 S 1" xref: DiffMono: "59.019356" xref: Formula: "C 6 H 12 N 2 O 1 S 1" xref: MassAvg: "160.24" xref: MassMono: "160.067034" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01079 name: S-(acetylamino)methyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-[(acetylamino)methyl]-L-cysteine." [DeltaMass:218, PubMed:8572278] comment: From DeltaMass: (name misspelled "Acetamidomethyl Cystenyl") Average Mass: 174 Formula: C 6 H 10 O 2 N 2 S 1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221. [These are aggregate masses, not delta masses.] See Organic Syntheses, Coll. Vol. 6, p.5 (1988); Vol. 59, p.190 (1979); http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv6p0005 [JSG]. synonym: "Acetamidomethyl Cystenyl" EXACT DeltaMass-label [] synonym: "Acm-Cys" EXACT PSI-MOD-alternate [] synonym: "N-(hydroxymethyl)acetamide derivatized L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S-(acetamido)methyl-L-cysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "71.08" xref: DiffFormula: "C 3 H 5 N 1 O 1 S 0" xref: DiffMono: "71.037114" xref: Formula: "C 6 H 10 N 2 O 2 S 1" xref: MassAvg: "174.22" xref: MassMono: "174.046299" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01080 name: acrylamidyl cysteinyl def: "modification from DeltaMass" [DeltaMass:219] comment: From DeltaMass: (name misspelled "Acrylamidyl Cystenyl") Average Mass: 174 Formula: C6H10O2N2S1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221 synonym: "Acrylamidyl Cystenyl" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 10 N 2 O 2 S 1" xref: MassAvg: "174.22" xref: MassMono: "174.046299" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01081 name: delta-glycosyloxy- (of lysine) or beta-glycosyloxy- (of phenylalanine or tyrosine) def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 177. CAUTION - mass does not match formula. xref: DiffAvg: "178.14" xref: DiffFormula: "C 6 H 10 O 6" xref: DiffMono: "178.047738" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01082 name: 4-glycosyloxy- (hexosyl, C6) (of proline) def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 177. Caution: Formula does not match mass. The natural glycosylating sugar of hydroxyproline is galactose. xref: DiffAvg: "178.14" xref: DiffFormula: "C 6 H 10 O 6" xref: DiffMono: "178.047738" xref: Formula: "C 11 H 17 N 1 O 6" xref: MassAvg: "259.26" xref: MassMono: "259.105587" xref: Origin: "P" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01083 name: O-benzyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-benzyl-L-serine." [DeltaMass:0] xref: DiffAvg: "90.13" xref: DiffFormula: "C 7 H 6" xref: DiffMono: "90.046950" xref: Formula: "C 10 H 11 N 1 O 2" xref: MassAvg: "177.20" xref: MassMono: "177.078979" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue [Term] id: MOD:01084 name: iodoacetic acid derivatized amino-terminal residue def: "A protein modification that by reaction of iodoacetic acid effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxymethyl group." [UniMod:6#N-term] subset: PSI-MOD-slim synonym: "Carboxymethyl" RELATED PSI-MS-label [] synonym: "Carboxymethyl (on Cysteine)" EXACT DeltaMass-label [] synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 O 2" xref: DiffMono: "58.005479" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00399 ! iodoacetic acid derivatized residue [Term] id: MOD:01085 name: alpha-N-gluconoylation (His Tagged proteins) def: "modification from DeltaMass" [DeltaMass:226] comment: From DeltaMass: Average Mass: 178 Formula: C6H10O6 Monoisotopic Mass Change: 178.05 Average Mass Change: 178.14 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01086 name: p-nitrobenzyloxycarbonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 179 synonym: "4Nz" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01087 name: 2,4,5-trichlorophenyl modified residue def: "A protein modification that effectively substitutes a 2,4,5-trichlorophenyl group for a hydrogen atom." [DeltaMass:0] xref: DiffAvg: "179.42" xref: DiffFormula: "C 6 Cl 3 H 1" xref: DiffMono: "177.914383" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01088 name: 2,4,6-trimethyloxybenzyl modified residue def: "A protein modification that effectively substitutes a 2,4,6-trimethyloxybenzyl group for a hydrogen atom." [DeltaMass:0] synonym: "Tmob" EXACT DeltaMass-label [] xref: DiffAvg: "180.20" xref: DiffFormula: "C 10 H 12 O 3" xref: DiffMono: "180.078644" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01089 name: xanthyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 180 synonym: "Xan" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01090 name: iodoacetamide derivatized amino-terminal residue def: "A protein modification that by reaction of iodoacetamide effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxamidomethyl group." [PubMed:11327326, PubMed:11510821, PubMed:12422359, UniMod:4#N-term] subset: PSI-MOD-slim synonym: "(carbamoylmethyl)amino" EXACT PSI-MOD-alternate [] synonym: "Carbamidomethyl" RELATED PSI-MS-label [] synonym: "Iodoacetamide derivative" RELATED UniMod-description [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1" xref: DiffMono: "57.021464" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00397 ! iodoacetamide derivatized residue [Term] id: MOD:01091 name: monochlorinated L-phenylalanine def: "A protein modification that effectively substitutes one hydrogen atom of an L-phenylalanine residue with one chlorine atom." [DeltaMass:233] comment: From DeltaMass: Average Mass: 182 Formula:C9H8O1N1Cl1 Monoisotopic Mass Change:181.029 Average Mass Change:181.623 synonym: "Cl1Phe" EXACT PSI-MOD-label [] xref: DiffAvg: "34.44" xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" xref: DiffMono: "33.961028" xref: Formula: "C 9 Cl 1 H 8 N 1 O 1" xref: MassAvg: "181.62" xref: MassMono: "181.029442" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01066 ! halogenated phenylalanine is_a: MOD:01911 ! monochlorinated residue [Term] id: MOD:01092 name: mesitylene-2-sulfonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 182 synonym: "Mts" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01093 name: isopropyl lysyl def: "modification from DeltaMass" [DeltaMass:236] comment: From DeltaMass: Average Mass: 184 Formula: C9H16O2N2 Monoisotopic Mass Change: 184.12 Average Mass Change: 184.24 with no citation. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 9 H 16 N 2 O 2" xref: MassAvg: "184.24" xref: MassMono: "184.121178" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01094 name: N6-carboxymethyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-carboxymethyl-L-lysine." [DeltaMass:237, UniMod:6#K] comment: From DeltaMass:237 (with no citation, formula incorrect, N and O reversed) Average Mass: 186 Formula: C8H14O2N3 Monoisotopic Mass Change: 186.1 Average Mass Change: 186.211 [JSG]. subset: PSI-MOD-slim synonym: "Carboxymethyl" RELATED PSI-MS-label [] synonym: "Carboxymethyl Lysyl" EXACT DeltaMass-label [] synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 O 2" xref: DiffMono: "58.005479" xref: Formula: "C 8 H 14 N 2 O 3" xref: MassAvg: "186.21" xref: MassMono: "186.100442" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00399 ! iodoacetic acid derivatized residue [Term] id: MOD:01095 name: Matrix alpha cyano MH+ def: "Modification from DeltaMass. OBSOLETE because not an amino acid modification." [DeltaMass:240] comment: From DeltaMass with no citation, formula incorrect, N and O reversed: Formula: C10H8O1N3 Monoisotopic Mass Change: 190.05 Average Mass Change: 190.18. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 10 H 8 N 1 O 3" xref: MassAvg: "190.18" xref: MassMono: "190.050418" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01096 name: O-benzyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-benzyl-L-threonine." [DeltaMass:0] xref: DiffAvg: "90.13" xref: DiffFormula: "C 7 H 6" xref: DiffMono: "90.046950" xref: Formula: "C 11 H 13 N 1 O 2" xref: MassAvg: "191.23" xref: MassMono: "191.094629" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue [Term] id: MOD:01097 name: S-benzyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-benzyl-L-cysteine." [DeltaMass:242] comment: From DeltaMass: misspelled "Benzyl Cystenyl". xref: DiffAvg: "90.13" xref: DiffFormula: "C 7 H 6" xref: DiffMono: "90.046950" xref: Formula: "C 10 H 11 N 1 O 1 S 1" xref: MassAvg: "193.26" xref: MassMono: "193.056135" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue [Term] id: MOD:01098 name: naphthylalanine residue def: "A protein modification that inserts or replaces a residue with a naphthylalanine." [DeltaMass:243] comment: From DeltaMass: Average Mass: 197 Formula: C13H11O1N1 Monoisotopic Mass Change: 197.084 Average Mass Change: 197.238. No citation provided. It is not obvious which isomer of naphthylalanine this DeltaMass entry is supposed to represent [JSG]. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 13 H 11 N 1 O 1" xref: MassAvg: "197.24" xref: MassMono: "197.084064" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00850 ! unnatural residue [Term] id: MOD:01099 name: succinyl beta-aspartyl anhydride def: "A protein modification that effectively converts an L-aspartic acid residue to succinyl beta-aspartyl anhydride." [DeltaMass:244] comment: From DeltaMass with no citation (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 198 Formula: C8H8O1N5 Monoisotopic Mass Change: 198.04 Average Mass Change: 198.156 [JSG]. synonym: "succinyl aspartamyl" EXACT DeltaMass-label [] xref: DiffAvg: "82.06" xref: DiffFormula: "C 4 H 2 N 0 O 2" xref: DiffMono: "82.005479" xref: Formula: "C 8 H 8 N 1 O 5" xref: MassAvg: "198.15" xref: MassMono: "198.040247" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01029 ! succinylated residue [Term] id: MOD:01100 name: HMP (hydroxymethylphenyl)/TFA adduct def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 201 with no citation. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01101 name: S-Farnesyl- def: "OBSOLETE because erroneous and apparently redundant to MOD:00111. Remap to MOD:00111." [DeltaMass:0] comment: Modification from DeltaMass: Average Mass: 206. This entry with no other information available appears to be the same as the entry at 204 for "Farnesylation" but with an incorrect mass. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01102 name: myristoylation-4H (two double bonds) def: "OBSOLETE because redundant and identical to MOD:00504. Remap to MOD:00504." [DeltaMass:348] comment: From DeltaMass: Average Mass: 206 Formula: C14 H22 O1 Monoisotopic Mass Change: 206.167 Average Mass Change: 206.324 References: Neubert TA, Johnson RS, Hurley JB, Walsh KA (1992). The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. J Biol Chem. 267(26), 18274-7. Notes: Modification of protein N-terminus with (cis,cis-delta 5, delta 8)-tetradecadienoyl group (myristoylation with 2 double bonds) xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01103 name: myristoleylation (one double bond) def: "OBSOLETE because redundant and identical to MOD:00503. Remap to MOD:00503." [DeltaMass:0] comment: From DeltaMass with no citation or formula: Average Mass: 208. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01104 name: 4-methoxy-2,3,6-trimethylbenzenesulfonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 212 with no citation. synonym: "Mtr" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01105 name: 2-bromobenzyloxycarbonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 213 with no citation. synonym: "BrZ" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01106 name: N-formyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to N-formyl-L-tryptophan." [DeltaMass:0] comment: From DeltaMass with no citation or formula: Average Mass: 214. It is not clear what this is supposed to represent. The mass corresponds to an N-formyl tryptophan (either N2 or N1'), but neither of these modifications has been reported as commonly encountered. It may have been confused with N'-formyl-L-kynurenine, see MOD:00464 [JSG] synonym: "formyl tryptophanyl" EXACT DeltaMass-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 12 H 10 N 2 O 2" xref: MassAvg: "214.22" xref: MassMono: "214.074228" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00409 ! N-formylated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01107 name: O5-benzyl-L-glutamate def: "A protein modification that effectively converts an L-glutamic acid residue to O5-benzyl-L-glutamate." [DeltaMass:258] comment: From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. xref: DiffAvg: "90.13" xref: DiffFormula: "C 7 H 6" xref: DiffMono: "90.046950" xref: Formula: "C 12 H 13 N 1 O 3" xref: MassAvg: "219.24" xref: MassMono: "219.089543" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue [Term] id: MOD:01108 name: 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid (Glu) def: "A protein modification that effectively converts an L-glutamic acid residue to 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid, glutamtic acid anisole adduct." [DeltaMass:259] comment: From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. synonym: "anisole adducted glutamyl" EXACT DeltaMass-label [] xref: DiffAvg: "90.13" xref: DiffFormula: "C 7 H 6" xref: DiffMono: "90.046950" xref: Formula: "C 12 H 13 N 1 O 3" xref: MassAvg: "219.24" xref: MassMono: "219.089543" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01007 ! anisyl modified residue [Term] id: MOD:01109 name: 9-fluorenylmethyloxycarbonyl (Fmoc) def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 222 with no citation. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01110 name: isoprenylated cysteine def: "A protein modification that effectively replaces a hydrogen atom of an L-cysteine residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20)." [PubMed:18688235] subset: PSI-MOD-slim synonym: "IpCys" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00703 ! isoprenylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01111 name: dimethoxybenzhydryl modified residue def: "A protein modification that effectively substitutes a dimethoxybenzhydryl group for a hydrogen atom." [DeltaMass:0] comment: From DeltaMass: Average Mass: 226 with no citation. A reagent, typically 4,4'-dimethoxybenzhydryl chloride, used as a protecting group for the carboxamido group of asparagine and glutamine during chemical peptide synthesis [JSG]. synonym: "4,4'-dimethoxybenzhydryl" EXACT PSI-MOD-alternate [] synonym: "bis(4-methoxyphenyl)methyl" EXACT PSI-MOD-alternate [] synonym: "Mbh" EXACT DeltaMass-label [] xref: DiffAvg: "226.27" xref: DiffFormula: "C 15 H 14 O 2" xref: DiffMono: "226.099380" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01112 name: nicotinoyl lysine def: "modification from DeltaMass" [DeltaMass:266] comment: From DeltaMass: (name misspelled "nicotinyl"; formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 233 Formula: C12H15O3N2 Monoisotopic Mass Change: 233.116 Average Mass Change: 233.271 synonym: "nicotinyl lysyl" EXACT DeltaMass-label [] xref: DiffAvg: "105.10" xref: DiffFormula: "C 6 H 3 N 1 O 1" xref: DiffMono: "105.021464" xref: Formula: "C 12 H 15 N 3 O 2" xref: MassAvg: "233.27" xref: MassMono: "233.116427" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01113 name: 2-(p-biphenyl)isopropyl-oxycarbonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 238 with no citation. synonym: "Bpoc" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01114 name: triphenylmethyl def: "modification from DeltaMass" [DeltaMass:270] comment: From DeltaMass: Average Mass: 242 Average Mass Change: 242.3 Notes: blocking group used in peptide synthesis for C,H,Q,N synonym: "Trityl" EXACT DeltaMass-label [] synonym: "Trt" EXACT DeltaMass-label [] xref: DiffAvg: "242.32" xref: DiffFormula: "C 19 H 14" xref: DiffMono: "242.109550" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01115 name: isoprenylated tryptophan def: "A protein modification that effectively replaces a hydrogen atom of an L-tryptophan residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20)." [PubMed:18688235] synonym: "IpTrp" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "W" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00703 ! isoprenylated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01116 name: S-farnesyl-L-cysteine methyl ester def: "A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester." [PubMed:15609361, RESID:AA0102#var, RESID:AA0105#var] subset: PSI-MOD-slim synonym: "SFarnOMeCys" EXACT PSI-MOD-label [] xref: DiffAvg: "218.38" xref: DiffFormula: "C 16 H 26 N 0 O 0 S 0" xref: DiffMono: "218.203451" xref: Formula: "C 19 H 32 N 1 O 2 S 1" xref: MassAvg: "338.53" xref: MassMono: "338.215375" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00905 ! modified L-cysteine residue relationship: has_functional_parent MOD:00111 ! S-farnesyl-L-cysteine relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester [Term] id: MOD:01117 name: pentamethyldihydrobenzofuransulfonyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 252 with no citation. synonym: "Pbf" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01118 name: alpha-N-6-phosphogluconoylation (His Tagged proteins) def: "modification from DeltaMass" [DeltaMass:275] comment: From DeltaMass: Average Mass: 258 Formula: C6H10O6HPO3 Monoisotopic Mass Change: 258.01 Average Mass Change: 258.12 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01119 name: S-geranylgeranyl-L-cysteine methyl ester def: "A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine methyl ester." [PubMed:1483450, PubMed:15609361, RESID:AA0104#var, RESID:AA0105#var] subset: PSI-MOD-slim synonym: "SGergerOMeCys" EXACT PSI-MOD-label [] xref: DiffAvg: "286.50" xref: DiffFormula: "C 21 H 34 N 0 O 0 S 0" xref: DiffMono: "286.266051" xref: Formula: "C 24 H 40 N 1 O 2 S 1" xref: MassAvg: "406.65" xref: MassMono: "406.277976" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00905 ! modified L-cysteine residue relationship: has_functional_parent MOD:00113 ! S-geranylgeranyl-L-cysteine relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester [Term] id: MOD:01120 name: 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue def: "A protein modification that is produced by formation of an adduct with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride." [DeltaMass:0] comment: From DeltaMass: Average Mass: 266 Notes: blocking group for Arg in peptide synthesis. CAS:112160-39-1 [JSG]. synonym: "2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromene-6-sulfonyl" EXACT PSI-MOD-alternate [] synonym: "2,2,5,7,8-pentamethyl-6-chromansulfonyl" EXACT PSI-MOD-alternate [] synonym: "2,2,5,7,8-pentamethyl-chromane-6-sulfonyl" EXACT PSI-MOD-alternate [] synonym: "2,2,5,7,8-pentamethylchroman-6-sulfonyl" EXACT PSI-MOD-alternate [] synonym: "2,2,5,7,8-pentamethylchroman-6-sulphonyl" EXACT PSI-MOD-alternate [] synonym: "3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonyl" EXACT PSI-MOD-alternate [] synonym: "Pmc" EXACT DeltaMass-label [] synonym: "PmcRes" EXACT PSI-MOD-label [] xref: DiffAvg: "266.36" xref: DiffFormula: "C 14 H 18 O 3 S 1" xref: DiffMono: "266.097665" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue [Term] id: MOD:01121 name: monomethoxytrityl def: "modification from DeltaMass" [DeltaMass:280] comment: From DeltaMass: Average Mass: 272 Average Mass Change: 272 synonym: "Mmt" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01122 name: 5'phos dCytidinyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 289 with no citation. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01123 name: monoiodated tyrosine def: "OBSOLETE because redundant and identical to MOD:01123. Remap to MOD:01123." [DeltaMass:0] comment: From DeltaMass: Average Mass: 289 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01124 name: aldohexosyl lysyl def: "modification from DeltaMass" [DeltaMass:285] comment: From DeltaMass: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 290 Formula: C12H22O2N6 Monoisotopic Mass Change: 290.148 Average Mass Change: 290.317 xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 N 0 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 12 H 22 N 2 O 6" xref: MassAvg: "290.32" xref: MassMono: "290.147786" xref: Origin: "K" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01125 name: 5'phos dThymidinyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 304 with no citation. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01126 name: 5'phos Cytidinyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 305 with no citation. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01127 name: 5'phos Uridinyl def: "OBSOLETE because redundant and identical to MOD:01166. Remap to MOD:01166." [DeltaMass:292] comment: From DeltaMass: Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01128 name: N-glycolneuraminic acid def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 307 with no citation. synonym: "NeuGc" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01129 name: 5'phos dAdenosyl def: "modification from DeltaMass" [DeltaMass:295] comment: From DeltaMass: Average Mass: 313 Formula: C10H12O5N5P1 Monoisotopic Mass Change: 313.058 Average Mass Change: 313.211 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01130 name: SucPhencarb Lysyl def: "modification from DeltaMass" [DeltaMass:297] comment: From DeltaMass: Average Mass: 327 Formula: C17H17O3N4 Monoisotopic Mass Change: 327.122 Average Mass Change: 327.342 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01131 name: 5'phos dGuanosyl def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 329 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01132 name: 5'phos Adenosinyl def: "OBSOLETE because redundant and identical to MOD:01165. Remap to MOD:01165." [DeltaMass:0] comment: From DeltaMass: Average Mass: 329 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01133 name: S-12-hydroxyfarnesyl-L-cysteine methyl ester def: "A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine methyl ester." [PubMed:17790543, RESID:AA0103#var, RESID:AA0105#var] synonym: "S12HyFarnOMeCys" EXACT PSI-MOD-label [] xref: DiffAvg: "234.38" xref: DiffFormula: "C 16 H 26 N 0 O 1 S 0" xref: DiffMono: "234.198365" xref: Formula: "C 19 H 32 N 1 O 3 S 1" xref: MassAvg: "354.53" xref: MassMono: "354.210290" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00905 ! modified L-cysteine residue relationship: has_functional_parent MOD:00112 ! S-12-hydroxyfarnesyl-L-cysteine relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester [Term] id: MOD:01134 name: fluorescein labelling of peptide N-terminal using NHS ester def: "modification from DeltaMass" [DeltaMass:306] comment: From DeltaMass: Average Mass: 359 Formula: C21H11O6 Monoisotopic Mass Change: 359.055 Average Mass Change: 359.315 Notes: Using the DHB matrix at low pH the carboxyl group and one of the oxygens on the flurorescein molecule are protinated so the delta mass is 2Da higher than most text book illustrations would indicate. See Bioconjugate Techniques by Greg Hermanson, Academic Press, page 305, figure 204. Text books of course just show the coupling reaction at neutral or basic pH. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01135 name: Hex-HexNAc def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 365 with no citation. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01136 name: dioctyl phthalate def: "modification from DeltaMass" [DeltaMass:309] comment: From DeltaMass: Average Mass: 391 Average Mass Change: 391 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01137 name: N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine def: "A protein modification that is produced by reaction of a lysine residue with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine." [DeltaMass:310] comment: From DeltaMass: Average Mass: Formula: C20H30O2N4S1 Monoisotopic Mass Change: 394.192 Average Mass Change: 394.534 synonym: "PMC lysyl" EXACT DeltaMass-label [] synonym: "PmcLys" EXACT PSI-MOD-label [] xref: DiffAvg: "266.36" xref: DiffFormula: "C 14 H 18 O 3 S 1" xref: DiffMono: "266.097665" xref: Formula: "C 20 H 30 N 2 O 4 S 1" xref: MassAvg: "394.53" xref: MassMono: "394.192628" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:01120 ! 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue [Term] id: MOD:01138 name: Aedans Cystenyl def: "modification from DeltaMass" [DeltaMass:311] comment: [probably aminoethyldansyl, JSG] From DeltaMass: (name misspelled "Aedans Cystenyl", and formula incorrect, N and O reversed) Average Mass: 409 Abbreviation: Aedans-Cys Formula: C17H19O3N5S2 Monoisotopic Mass Change: 409.077 Average Mass Change: 409.482 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01139 name: dioctyl phthalate sodium adduct def: "modification from DeltaMass" [DeltaMass:312] comment: From DeltaMass: Mass: Average Mass Change: 413 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01140 name: diiodinated tyrosine def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two iodine atoms." [DeltaMass:0, OMSSA:35, PubMed:15627961, UniMod:130#Y] subset: PSI-MOD-slim synonym: "3,5-Diiodination (of Tyrosine)" EXACT DeltaMass-label [] synonym: "di-Iodination" RELATED UniMod-description [] synonym: "diiodinationy" EXACT OMSSA-label [] synonym: "Diiodo" RELATED PSI-MS-label [] synonym: "I2Tyr" EXACT PSI-MOD-label [] xref: DiffAvg: "251.79" xref: DiffFormula: "C 0 H -2 I 2 N 0 O 0" xref: DiffMono: "251.793295" xref: Formula: "C 9 H 7 I 2 N 1 O 2" xref: MassAvg: "414.97" xref: MassMono: "414.856624" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00501 ! diiodinated residue is_a: MOD:00998 ! iodinated tyrosine [Term] id: MOD:01141 name: omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine def: "A protein modification that is produced by reaction with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine." [DeltaMass:314] comment: From DeltaMass: Average Mass: Formula: C20H30O4N4S1 Monoisotopic Mass Change: 422.199 Average Mass Change: 422.547 synonym: "PMC arginyl" EXACT DeltaMass-label [] synonym: "PmcArg" EXACT PSI-MOD-label [] xref: DiffAvg: "266.36" xref: DiffFormula: "C 14 H 18 O 3 S 1" xref: DiffMono: "266.097665" xref: Formula: "C 20 H 30 N 4 O 4 S 1" xref: MassAvg: "422.54" xref: MassMono: "422.198776" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:01120 ! 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue [Term] id: MOD:01142 name: S-15,16-dihydrobiliverdin-L-cysteine def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound 15,16-dihydrobiliverdin." [PubMed:10430868, PubMed:15504407, PubMed:1559975, PubMed:3208761, RESID:AA0428] synonym: "(16R)-18-ethenyl-8,12-bis(2-carboxyethyl)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione" EXACT RESID-systematic [] synonym: "15,16-Dhbv" EXACT RESID-alternate [] synonym: "15,16-dihydrobiliverdin cysteine adduct" EXACT RESID-alternate [] synonym: "15,16-dihydrobiliverdin IXalpha" EXACT RESID-alternate [] synonym: "18-ethenyl-8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione" EXACT RESID-alternate [] synonym: "3'-cysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate [] synonym: "3alpha-cysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate [] synonym: "BINDING 15,16-dihydrobiliverdin (covalent; via 1 link)" EXACT UniProt-feature [] synonym: "DBV" EXACT RESID-alternate [] synonym: "S-15,16-dihydrobiliverdin-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "584.67" xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0" xref: DiffMono: "584.263485" xref: Formula: "C 36 H 41 N 5 O 7 S 1" xref: MassAvg: "687.81" xref: MassMono: "687.272670" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01143 name: 15,16-dihydrobiliverdin-bis-L-cysteine def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound 15,16-dihydrobiliverdin." [PubMed:1559975, PubMed:2222853, PubMed:3208761, PubMed:8420941, RESID:AA0429] comment: Cross-link 2. synonym: "(16R)-8,12-bis(2-carboxyethyl)-3-[2-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-[(1Xi)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione" EXACT RESID-systematic [] synonym: "15,16-Dhbv" EXACT RESID-alternate [] synonym: "15,16-dihydrobiliverdin cysteine adduct" EXACT RESID-alternate [] synonym: "15,16-dihydrobiliverdin IXalpha" EXACT RESID-alternate [] synonym: "15,16-dihydrobiliverdin-bis-L-cysteine" EXACT RESID-name [] synonym: "3'',18'-biscysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate [] synonym: "3beta,18alpha-biscysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate [] synonym: "8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-18-(1-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione" EXACT RESID-alternate [] synonym: "BINDING 15,16-dihydrobiliverdin (covalent; via 2 links)" EXACT UniProt-feature [] synonym: "DBV" EXACT RESID-alternate [] xref: DiffAvg: "584.67" xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0" xref: DiffMono: "584.263485" xref: Formula: "C 39 H 46 N 6 O 8 S 2" xref: MassAvg: "790.95" xref: MassMono: "790.281854" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01144 name: S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine." [DeltaMass:0, PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107#var] comment: From DeltaMass: Average Mass: 524 subset: PSI-MOD-slim synonym: "S-(sn-1-Dipalmitoyl-glyceryl)- (on Cysteine)" EXACT DeltaMass-label [] xref: DiffAvg: "550.91" xref: DiffFormula: "C 35 H 66 N 0 O 4 S 0" xref: DiffMono: "550.496111" xref: Formula: "C 38 H 71 N 1 O 5 S 1" xref: MassAvg: "654.05" xref: MassMono: "653.505295" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00116 ! S-diacylglycerol-L-cysteine [Term] id: MOD:01145 name: N-tau-(ADP-ribosyl)diphthamide def: "A protein modification that effectively converts an L-histidine residue to N-tau-(ADP-ribosyl)diphthamide." [DeltaMass:0] comment: From DeltaMass: (name misspelled "N theta -(ADP-ribosyl) diphthamide (of Histidine)") Average Mass: 648 xref: DiffAvg: "684.51" xref: DiffFormula: "C 22 H 36 N 7 O 14 P 2" xref: DiffMono: "684.178999" xref: FormalCharge: "1+" xref: Formula: "C 28 H 43 N 10 O 15 P 2" xref: MassAvg: "821.65" xref: MassMono: "821.237910" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00909 ! modified L-histidine residue relationship: derives_from MOD:00049 ! 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine [Term] id: MOD:01146 name: S-(6-FAD)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(6-FAD)-L-cystine." [DeltaMass:0] comment: From DeltaMass: Average Mass: 784 with no citation. This modification has not been reported [JSG]. subset: PSI-MOD-slim synonym: "FAD" RELATED PSI-MS-label [] synonym: "S6FADCys" EXACT PSI-MOD-label [] xref: DiffAvg: "783.54" xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2 S 0" xref: DiffMono: "783.141485" xref: Formula: "C 30 H 36 N 10 O 16 P 2 S 1" xref: MassAvg: "886.68" xref: MassMono: "886.150669" xref: Origin: "C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00895 ! FAD modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01147 name: (Hex)3-HexNAc-(dHex)HexNAc def: "modification from DeltaMass" [DeltaMass:0] comment: From DeltaMass: Average Mass: 1,039 xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00947 ! DeltaMass [Term] id: MOD:01148 name: ubiquitinylated lysine def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin." [PubMed:11125103, PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01875 ! N6-acylated L-lysine relationship: contains MOD:00134 ! N6-glycyl-L-lysine [Term] id: MOD:01149 name: sumoylated lysine def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein." [PubMed:12612601, PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01875 ! N6-acylated L-lysine relationship: contains MOD:00134 ! N6-glycyl-L-lysine [Term] id: MOD:01150 name: neddylated lysine def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein." [PubMed:11125103, PubMed:12612601, PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01875 ! N6-acylated L-lysine relationship: contains MOD:00134 ! N6-glycyl-L-lysine [Term] id: MOD:01151 name: phosphorylated residue with neutral loss of phosphate def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid phosphorylated residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "-97.99" xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1" xref: DiffMono: "-97.976895" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00432 ! modified residue with neutral loss of phosphate [Term] id: MOD:01152 name: carboxylated residue def: "A protein modification that effectively replaces a hydrogen atom with a carboxylic acid group." [UniMod:299] subset: PSI-MOD-slim synonym: "Carboxy" RELATED UniMod-interim [] synonym: "Carboxylation" RELATED UniMod-description [] xref: DiffAvg: "44.01" xref: DiffFormula: "C 1 H 0 N 0 O 2" xref: DiffMono: "43.989829" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01153 name: methylthiolated residue def: "A protein modification that effectively replaces a hydrogen atom with an methylsulfanyl group (thiomethyl group)." [UniMod:39] subset: PSI-MOD-slim synonym: "Beta-methylthiolation" RELATED UniMod-description [] synonym: "Methylthio" RELATED UniMod-interim [] xref: DiffAvg: "46.09" xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1" xref: DiffMono: "45.987721" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01886 ! thiolated residue [Term] id: MOD:01154 name: pyruvic acid def: "A protein modification that effectively converts a source amino acid to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127] subset: PSI-MOD-slim synonym: "2-oxopropanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES Pyruvic acid (Cys)" EXACT UniProt-feature [] synonym: "MOD_RES Pyruvic acid (Ser)" EXACT UniProt-feature [] synonym: "pyruvic acid" EXACT RESID-name [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 3 H 3 O 2" xref: MassAvg: "71.06" xref: MassMono: "71.013304" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "N-term" is_a: MOD:00769 ! residues isobaric at 71.0-71.1 Da is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01155 name: lipoconjugated residue def: "A protein modification that effectively results from forming an adduct with a compound containing a lipid-like group either through acylation, alkylation, or amidation." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01156 name: protein modification categorized by chemical process def: "Modified amino acid residue derived from a natural amino acid by a real or hypothetical chemical process." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00000 ! protein modification [Term] id: MOD:01157 name: protein modification categorized by amino acid modified def: "A protein modification considered either as modified amino acid residues derived from natural amino acids, as a replacement by another natural amino acid, or as a replacement by an unnatural amino acid." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00000 ! protein modification [Term] id: MOD:01158 name: modified L-selenocysteine residue def: "A protein modification that modifies an L-selenocysteine residue." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "U" is_a: MOD:00745 ! selenium containing residue is_a: MOD:01157 ! protein modification categorized by amino acid modified relationship: derives_from MOD:00031 ! L-selenocysteine residue [Term] id: MOD:01159 name: peptidoglycanated residue def: "A protein modification that effectively attaches a residue to murein peptidoglycan by either a pentaglycine linker peptide or a peptide-like L-alanyl-D-glutamyl-2,6-diaminopimelic acid linkage." [PubMed:18688235] xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00764 ! glycoconjugated residue [Term] id: MOD:01160 name: deaminated residue def: "A protein modification that effectively results in the loss of an ammonia, usually by a process of vicinal dehydration, rearrangement, and rehydration with release of ammonia, resulting in a loss of nitrogen with no gain of oxygen." [UniMod:385] subset: PSI-MOD-slim synonym: "Ammonia-loss" RELATED UniMod-interim [] synonym: "Loss of ammonia" RELATED UniMod-description [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01161 name: deoxygenated residue def: "A protein modification that effectively removes oxygen atoms from a residue without the removal of hydrogen atoms." [PubMed:14235557, UniMod:447] subset: PSI-MOD-slim synonym: "Deoxy" RELATED PSI-MS-label [] synonym: "dOxyRes" EXACT PSI-MOD-label [] synonym: "reduction" RELATED UniMod-description [] xref: DiffAvg: "-16.00" xref: DiffFormula: "C 0 H 0 N 0 O -1" xref: DiffMono: "-15.994915" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01472 ! reduced residue [Term] id: MOD:01162 name: fucosylated biantennary def: "modification from UniMod N-linked glycosylation" [UniMod:308] synonym: "dHex(1)Hex(5)HexNAc(4)" RELATED PSI-MS-label [] synonym: "Fucosylated biantennary" RELATED UniMod-description [] xref: DiffAvg: "1769.62" xref: DiffFormula: "C 68 H 112 N 4 O 49" xref: DiffMono: "1768.639516" xref: Formula: "C 72 H 118 N 6 O 51" xref: MassAvg: "1883.73" xref: MassMono: "1882.682443" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00725 ! complex glycosylation [Term] id: MOD:01163 name: guanylated residue def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoguanosine through either a phosphodiester or a phosphoramide bond." [DeltaMass:304, UniMod:413] comment: From DeltaMass: (formula incorrect, N and O reversed) Average Mass: 345 Formula: C10H12O5N7P1 Monoisotopic Mass Change: 345.047 Average Mass Change: 345.209. synonym: "5'phos Guanosyl" EXACT DeltaMass-label [] synonym: "phospho-guanosine" RELATED UniMod-description [] synonym: "Phosphoguanosine" RELATED PSI-MS-label [] xref: DiffAvg: "345.21" xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1" xref: DiffMono: "345.047434" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00701 ! nucleotide or nucleic acid modified residue [Term] id: MOD:01164 name: riboflavin-phosphoryl def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through a phosphodiester bond." [UniMod:442] subset: PSI-MOD-slim synonym: "FMN" RELATED PSI-MS-label [] synonym: "O3-(riboflavin phosphoryl)" RELATED UniMod-description [] xref: DiffAvg: "438.33" xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1" xref: DiffMono: "438.094050" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00896 ! FMN modified residue [Term] id: MOD:01165 name: adenylated residue def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoadenosine through either a phosphodiester or a phosphoramide bond." [DeltaMass:0, UniMod:405] comment: From DeltaMass: (name misspelled "5'phos adenosinyl") Average Mass: 329 subset: PSI-MOD-slim synonym: "5'phos Adenosinyl" EXACT DeltaMass-label [] synonym: "AMP binding site" RELATED UniMod-description [] synonym: "Phosphoadenosine" RELATED PSI-MS-label [] xref: DiffAvg: "329.21" xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" xref: DiffMono: "329.052520" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00701 ! nucleotide or nucleic acid modified residue [Term] id: MOD:01166 name: uridylated residue def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphouridine through either a phosphodiester or a phosphoramide bond." [DeltaMass:292, UniMod:417] comment: From DeltaMass: (name misspelled "5'phos Uridinyl" and formula incorrect, N and O reversed) Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 synonym: "5'phos Uridinyl" EXACT DeltaMass-label [] synonym: "PhosphoUridine" RELATED PSI-MS-label [] synonym: "uridine phosphodiester" RELATED UniMod-description [] xref: DiffAvg: "306.17" xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1" xref: DiffMono: "306.025302" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00701 ! nucleotide or nucleic acid modified residue [Term] id: MOD:01167 name: molybdopterin guanine dinucleotide def: "modification from UniMod" [UniMod:424] synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED UniMod-description [] synonym: "MolybdopterinGD" RELATED PSI-MS-label [] xref: DiffAvg: "1572.02" xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4" xref: DiffMono: "1572.985775" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00744 ! molybdenum pterin containing modification [Term] id: MOD:01168 name: dehydroalanine def: "A protein modification that effectively converts a source amino acid residue to dehydroalanine." [PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:6838602, PubMed:7947813, PubMed:8239649, RESID:AA0181] subset: PSI-MOD-slim synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] synonym: "anhydroserine" EXACT RESID-alternate [] synonym: "dehydroalanine" EXACT RESID-name [] synonym: "Dha" EXACT RESID-alternate [] synonym: "dHAla" EXACT PSI-MOD-label [] synonym: "MOD_RES 2,3-didehydroalanine (Cys)" EXACT UniProt-feature [] synonym: "MOD_RES 2,3-didehydroalanine (Ser)" EXACT UniProt-feature [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 3 H 3 N 1 O 1" xref: MassAvg: "69.06" xref: MassMono: "69.021464" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01169 name: L-3-oxoalanine def: "A protein modification that effectively converts a source amino acid residue to L-oxoalanine." [DeltaMass:349, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9478923, RESID:AA0185] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate [] synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer [] synonym: "L-3-oxoalanine" EXACT RESID-name [] synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate [] synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate [] synonym: "L-serinesemialdehyde" RELATED RESID-misnomer [] synonym: "MOD_RES 3-oxoalanine (Cys)" EXACT UniProt-feature [] synonym: "MOD_RES 3-oxoalanine (Ser)" EXACT UniProt-feature [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 3 H 3 N 1 O 2" xref: MassAvg: "85.06" xref: MassMono: "85.016378" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01170 name: pyruvic acid iminylated residue def: "A protein modification that effectively forms a 2-ketoimine of pyruvicacid with a residue amino group." [UniMod:422] synonym: "N-pyruvic acid 2-iminyl" RELATED UniMod-description [] synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label [] xref: DiffAvg: "70.05" xref: DiffFormula: "C 3 H 2 N 0 O 2" xref: DiffMono: "70.005479" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "N-term" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01171 name: O-acetyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-acetyl-L-threonine." [PubMed:16728640, RESID:AA0423, UniMod:1#T] subset: PSI-MOD-slim synonym: "(2S,3R)-3-(acetyloxy)-2-aminobutanoic acid" EXACT RESID-systematic [] synonym: "Acetylation" RELATED UniMod-description [] synonym: "ACT_SITE O-acetylthreonine intermediate" EXACT UniProt-feature [] synonym: "MOD_RES O-acetylthreonine" EXACT UniProt-feature [] synonym: "O-acetyl-L-threonine" EXACT RESID-name [] synonym: "O-acetylthreonine" EXACT RESID-alternate [] synonym: "OAcThr" EXACT PSI-MOD-label [] synonym: "threonine acetate ester" EXACT RESID-alternate [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "C 6 H 9 N 1 O 3" xref: MassAvg: "143.14" xref: MassMono: "143.058243" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00644 ! O-acetylated residue is_a: MOD:01186 ! acetylated L-threonine [Term] id: MOD:01172 name: N-alanyl-glycosylsphingolipidinositolethanolamine def: "A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, RESID:AA0424] synonym: "GSIAla" EXACT PSI-MOD-label [] synonym: "LIPID GPI-like-anchor amidated alanine" EXACT UniProt-feature [] synonym: "N-alanyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 5 H 12 N 2 O 5 P 1" xref: MassAvg: "211.13" xref: MassMono: "211.048383" xref: Origin: "A" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00466 ! glycosylsphingolipidinositolated residue is_a: MOD:00901 ! modified L-alanine residue [Term] id: MOD:01173 name: N-asparaginyl-glycosylsphingolipidinositolethanolamine def: "A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, RESID:AA0425] synonym: "GSIAsn" EXACT PSI-MOD-label [] synonym: "LIPID GPI-like-anchor amidated asparagine" EXACT UniProt-feature [] synonym: "N-asparaginyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 6 H 13 N 3 O 6 P 1" xref: MassAvg: "254.16" xref: MassMono: "254.054197" xref: Origin: "N" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00466 ! glycosylsphingolipidinositolated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:01174 name: S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine." [ChEBI:27485, PubMed:11466314, PubMed:12684535, RESID:AA0426] synonym: "(2R)-2-amino-3-([(5Z,9Xi,12E,14Z)-1-hydroxy-1,11-oxoprosta-5,12,14-trien-9-yl]sulfanyl)propanoic acid" EXACT RESID-alternate [] synonym: "(5Z,9Xi,12E,14Z)-9-([(2R)-2-amino-3-carboxyethyl]sulfanyl)-11-oxoprosta-5,12,14-trien-1-oic acid" EXACT RESID-systematic [] synonym: "LIPID S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine" EXACT UniProt-feature [] synonym: "PG-J2Cys" EXACT PSI-MOD-label [] synonym: "S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "316.44" xref: DiffFormula: "C 20 H 28 N 0 O 3 S 0" xref: DiffMono: "316.203845" xref: Formula: "C 23 H 33 N 1 O 4 S 1" xref: MassAvg: "419.58" xref: MassMono: "419.213030" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01155 ! lipoconjugated residue [Term] id: MOD:01175 name: S-phycourobilin-L-cysteine def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycourobilin." [PubMed:1903388, PubMed:3208761, PubMed:3838747, RESID:AA0427] synonym: "(2S,3R,16R)-18-ethenyl-3-[(1R)-1-([(R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydrobiline-1,19(21H,22H,24H)-dione" EXACT RESID-systematic [] synonym: "18-ethenyl-3-[1-(2-amino-2-carboxyethylsulfanyl)ethyl]-2,3,15,16-dihydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate [] synonym: "BINDING Phycourobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature [] synonym: "phycourobilin cysteine adduct" EXACT RESID-alternate [] synonym: "PUB" EXACT RESID-alternate [] synonym: "PUBCys" EXACT PSI-MOD-label [] synonym: "S-phycourobilin-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "586.69" xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0" xref: DiffMono: "586.279135" xref: Formula: "C 36 H 43 N 5 O 7 S 1" xref: MassAvg: "689.83" xref: MassMono: "689.288320" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00700 ! tetrapyrrole modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01176 name: L-dehydrolysinonorleucine def: "A protein modification that effectively cross-links an L-lysine residue and an L-lysine residue converted to allysine with a carbon-nitrogen bond to form L-dehydrolysinonorleucine." [PubMed:16929109, RESID:AA0430] comment: Cross-link 2. synonym: "(2S)-2-amino-6-([(5S)-5-amino-5-carboxypentylidene]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "6-(N6-L-didehydrolysino)-L-norleucine" EXACT RESID-alternate [] synonym: "CROSSLNK Dehydrolysinonorleucine (Lys-Lys)" EXACT UniProt-feature [] synonym: "dehydrolysinorleucine [misspelling]" EXACT RESID-alternate [] synonym: "dehydrolysylnorleucine" EXACT RESID-alternate [] synonym: "didehydrolysinonorleucine" EXACT RESID-alternate [] synonym: "L-dehydrolysinonorleucine" EXACT RESID-name [] synonym: "N6-[(5S)-5-amino-5-carboxypentylidene]-L-lysine" EXACT RESID-alternate [] synonym: "XLNK6NleN6Lys" EXACT PSI-MOD-label [] xref: DiffAvg: "-19.05" xref: DiffFormula: "C 0 H -5 N -1 O 0" xref: DiffMono: "-19.042199" xref: Formula: "C 12 H 19 N 3 O 2" xref: MassAvg: "237.30" xref: MassMono: "237.147727" xref: Origin: "K, K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01177 name: 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine def: "A protein modification that effectively converts an L-histidine residue to 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine." [PubMed:16760471, RESID:AA0431] synonym: "(S)-2-amino-3-[1-(1,2,3-trihydroxypropan-2-yl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-systematic [] synonym: "1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine" EXACT RESID-name [] synonym: "1-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]-L-histidine" EXACT RESID-alternate [] synonym: "MOD_RES Tele-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT UniProt-feature [] synonym: "N(epsilon)-histidine dihydroxyacetone adduct" EXACT RESID-alternate [] synonym: "N(tau)-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT RESID-alternate [] synonym: "NtauDHAHis" EXACT PSI-MOD-label [] synonym: "tele-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT RESID-alternate [] xref: DiffAvg: "90.08" xref: DiffFormula: "C 3 H 6 N 0 O 3" xref: DiffMono: "90.031694" xref: Formula: "C 9 H 13 N 3 O 4" xref: MassAvg: "227.22" xref: MassMono: "227.090606" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01178 name: S-(aspart-4-yloxy) thiocarbonate def: "A protein modification that effectively converts an L-aspartic acid residue to S-(aspart-4-yloxy) thiocarbonate." [PubMed:16627948, RESID:AA0432] comment: This modification was originally observed in an Entamoeba histolytica enzyme expressed in Escherichia coli. It was not chemically confirmed or characterized. It did not appear in a later model at higher resolution by the same group. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. synonym: "(2S)-2-amino-4-(carboxysulfanyl)oxy-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "4-aspartyloxysulfanylcarbonate" EXACT RESID-alternate [] synonym: "AspOSCO2H" EXACT PSI-MOD-label [] synonym: "O-carboxysulfanyl-4-oxo-L-homoserine" EXACT RESID-alternate [] synonym: "S-(aspart-4-yloxy) thiocarbonate" EXACT RESID-name [] xref: DiffAvg: "76.07" xref: DiffFormula: "C 1 H 0 N 0 O 2 S 1" xref: DiffMono: "75.961900" xref: Formula: "C 5 H 5 N 1 O 5 S 1" xref: MassAvg: "191.16" xref: MassMono: "190.988843" xref: Origin: "D" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:01179 name: N,N-dimethyl-L-alanine def: "A protein modification that effectively converts an L-alanine residue to N,N-dimethyl-L-alanine." [PubMed:17691833, PubMed:387091, RESID:AA0433] synonym: "(S)-1-carboxy-N,N-dimethylaminoethane" EXACT RESID-alternate [] synonym: "(S)-2-(dimethylamino)propanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES N,N-dimethylalanine" EXACT UniProt-feature [] synonym: "N,N-dimethyl-L-alanine" EXACT RESID-name [] synonym: "N,N-dimethylalanine" EXACT RESID-alternate [] synonym: "NMe2Ala" EXACT PSI-MOD-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 5 H 10 N 1 O 1" xref: MassAvg: "100.14" xref: MassMono: "100.076239" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01461 ! N-methylated alanine is_a: MOD:01686 ! alpha-amino dimethylated residue [Term] id: MOD:01180 name: 2-hydroxyglycine observational artifact def: "A protein modification that effectively converts a glycine residue to 2-hydroxyglycine." [ChEBI:38048, PubMed:16178056, PubMed:17431180, PubMed:17823333, RESID:AA0434] comment: CAUTION - peptides of 2-hydroxyglycine are known to be unstable, decaying to break the peptide backbone or to form peptidyl amides [see J. Am. Chem. Soc. 111, 1933-1934, 1989, and J. Org. Chem. 57, 3916-3921, 1992]. If computer analysis of tandem mass-spectrometric results predicts this modification, then it is most probable that there are multiple isobaric peptides differing in the location of multiple hydroxylation modifications [JSG]. synonym: "2-hydroxyglycine" EXACT RESID-name [] synonym: "2HyGly" EXACT PSI-MOD-label [] synonym: "alpha-hydroxyglycine" EXACT RESID-alternate [] synonym: "amino(hydroxy)acetic acid" EXACT RESID-systematic [] synonym: "aminohydroxyacetic acid" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 2 H 3 N 1 O 2" xref: MassAvg: "73.05" xref: MassMono: "73.016378" xref: Origin: "G" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:01181 name: L-aspartic acid 4-methyl ester def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartate 4-methyl ester." [OMSSA:69, PubMed:1556110, PubMed:16888766, PubMed:9629898, RESID:AA0435, UniMod:34#D] comment: CAUTION - observations of this modifation are attributable to artifacts produced in preparation. It is extremely unlikely that eukaryotes produce this modification, because an enzyme acting to form the methyl ester of L-aspartyl peptides would interfere with the D-aspartyl peptide repair mechanism [JSG]. synonym: "(2S)-2-amino-4-methoxy-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "2-aminobutanedioic acid 4-methyl ester" EXACT RESID-alternate [] synonym: "4-methyl L-2-aminosuccinic acid" EXACT RESID-alternate [] synonym: "4-methyl L-aspartate" EXACT RESID-alternate [] synonym: "4-methyl L-hydrogen aspartate" EXACT RESID-alternate [] synonym: "aspartic acid 4-methyl ester" EXACT RESID-alternate [] synonym: "aspartic acid beta-methyl ester" EXACT RESID-alternate [] synonym: "L-aspartic acid 4-methyl ester" EXACT RESID-name [] synonym: "meesterd" EXACT OMSSA-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "O4MeAsp" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00393 ! O-methylated residue is_a: MOD:01681 ! monomethylated L-aspartic acid [Term] id: MOD:01182 name: 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD def: "A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD." [PubMed:, RESID:AA0436] comment: Cross-link 2. subset: PSI-MOD-slim synonym: "6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine" EXACT RESID-systematic [] synonym: "6-(S-cysteinyl)-8alpha-(N(delta1)-histidyl)-FAD" EXACT RESID-alternate [] synonym: "6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FAD" EXACT RESID-alternate [] synonym: "6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FAD" EXACT RESID-alternate [] synonym: "6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD" EXACT RESID-alternate [] synonym: "6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FAD" EXACT RESID-name [] synonym: "BINDING FAD (covalent; via 2 links)" EXACT UniProt-feature [] synonym: "BINDING FAD (covalent; via 2 links, pros nitrogen)" EXACT UniProt-feature [] synonym: "SCys6-NprosHis8a-FAD" EXACT PSI-MOD-label [] xref: DiffAvg: "781.52" xref: DiffFormula: "C 27 H 29 N 9 O 15 P 2 S 0" xref: DiffMono: "781.125835" xref: Formula: "C 36 H 41 N 13 O 17 P 2 S 1" xref: MassAvg: "1021.81" xref: MassMono: "1021.193931" xref: Origin: "C, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00895 ! FAD modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01621 ! flavin crosslinked residues [Term] id: MOD:01183 name: L-selenocystine (oxidized selenocysteine) (Sec-Sec) def: "A protein modification that effectively cross-links two L-selenocysteine residues to form L-selenocystine," [ChEBI:28553, PubMed:17715293, PubMed:6076213, RESID:AA0437] comment: Cross-link 2; for formation of the same modification by substitution of 2 selenium for 2 sulfur atoms in L-cystine, see MOD:01184. subset: PSI-MOD-slim synonym: "(R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "3,3'-diselenobis(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "3,3'-diselenobisalanine" EXACT RESID-alternate [] synonym: "3,3'-diselenodialanine" EXACT RESID-alternate [] synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide" EXACT RESID-alternate [] synonym: "beta,beta'-diselenodialanine" EXACT RESID-alternate [] synonym: "bis(alpha-aminopropionic acid)-beta-diselenide" EXACT RESID-alternate [] synonym: "bis(beta-amino-beta-carboxyethyl)diselenide" EXACT RESID-alternate [] synonym: "CROSSLNK Selenocystine (Sec-Sec)" EXACT UniProt-feature [] synonym: "diselenocysteine" EXACT RESID-alternate [] synonym: "L-selenocystine" EXACT RESID-name [] synonym: "Sec2" EXACT PSI-MOD-label [] synonym: "selenium cystine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 Se 0" xref: DiffMono: "-2.015650" xref: Formula: "C 6 H 8 N 2 O 2 Se 2" xref: MassAvg: "298.08" xref: MassMono: "299.891620" xref: Origin: "U, U" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:01158 ! modified L-selenocysteine residue [Term] id: MOD:01184 name: L-selenocystine (selenium disubstituted L-cystine) def: "A protein modification that effectively substitutes two selenium atoms for two sulfur atoms in L-cystine to form L-selenocystine." [PubMed:17715293, RESID:AA0437#CYS2] comment: Cross-link 2; for formation of the same modification by oxidation of two L-selenocysteine residues, see MOD:01183. synonym: "(R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "3,3'-diselenobis(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "3,3'-diselenobisalanine" EXACT RESID-alternate [] synonym: "3,3'-diselenodialanine" EXACT RESID-alternate [] synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide" EXACT RESID-alternate [] synonym: "beta,beta'-diselenodialanine" EXACT RESID-alternate [] synonym: "bis(alpha-aminopropionic acid)-beta-diselenide" EXACT RESID-alternate [] synonym: "bis(beta-amino-beta-carboxyethyl)diselenide" EXACT RESID-alternate [] synonym: "CROSSLNK Selenocystine (Sec-Sec)" EXACT UniProt-feature [] synonym: "diselenocysteine" EXACT RESID-alternate [] synonym: "L-selenocystine" EXACT RESID-name [] synonym: "Se2(S2)Cys2" EXACT PSI-MOD-label [] synonym: "selenium cystine" EXACT RESID-alternate [] xref: DiffAvg: "91.81" xref: DiffFormula: "C 0 H -2 N 0 O 0 S -2 Se 2" xref: DiffMono: "93.873250" xref: Formula: "C 6 H 8 N 2 O 2 Se 2" xref: MassAvg: "298.08" xref: MassMono: "299.891620" xref: Origin: "C, C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00007 ! selenium substitution for sulfur is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01185 name: 4-amidated L-aspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to L-asparagine." [PubMed:17962566, RESID:AA0003#ASP] synonym: "(2S)-2-amino-4-butanediamic acid" EXACT RESID-systematic [] synonym: "2,4-bis(azanyl)-4-oxobutanoic acid" EXACT RESID-alternate [] synonym: "2,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate [] synonym: "2-amino-3-carbamoylpropanoic acid" EXACT RESID-alternate [] synonym: "2-amino-4-butanediamic acid" EXACT RESID-alternate [] synonym: "2-aminosuccinamic acid" EXACT RESID-alternate [] synonym: "2-aminosuccinic acid 4-amide" EXACT RESID-alternate [] synonym: "4NAsp" EXACT PSI-MOD-label [] synonym: "alpha-amino-beta-carbamylpropionic acid" EXACT RESID-alternate [] synonym: "alpha-aminosuccinamic acid" EXACT RESID-alternate [] synonym: "aspartic acid 4-amide" EXACT RESID-alternate [] synonym: "aspartic acid beta-amide" EXACT RESID-alternate [] synonym: "beta-asparagine" EXACT RESID-alternate [] synonym: "L-asparagine" EXACT RESID-name [] synonym: "MOD_RES Amidated aspartic acid" EXACT UniProt-feature [] xref: DiffAvg: "-0.98" xref: DiffFormula: "C 0 H 1 N 1 O -1" xref: DiffMono: "-0.984016" xref: Formula: "C 4 H 6 N 2 O 2" xref: MassAvg: "114.10" xref: MassMono: "114.042927" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00012 ! L-asparagine residue is_a: MOD:00674 ! amidated residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:01186 name: acetylated L-threonine def: "A protein modification that effectively converts an L-threonine residue to either N-acetyl-L-threonne, or O-acetyl-Lthreonine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "AcThr" EXACT PSI-MOD-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "T" xref: Source: "natural" is_a: MOD:00394 ! acetylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01187 name: L-pyrrolysine residue def: "A protein modification that inserts or replaces a residue with an L-pyrrolysine residue, a natural pretranslational modification." [ChEBI:21860, PubMed:11435424, PubMed:12029131, PubMed:12029132, PubMed:15314242, PubMed:16096277, RESID:AA0321, UniMod:435] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid" EXACT RESID-alternate [] synonym: "L-pyrrolysine" EXACT RESID-name [] synonym: "monomethylamine methyltransferase cofactor lysine adduct" EXACT RESID-alternate [] synonym: "N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine" EXACT RESID-alternate [] synonym: "NON_STD Pyrrolysine" EXACT UniProt-feature [] synonym: "Pyl" EXACT PSI-MOD-label [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 12 H 19 N 3 O 2" xref: MassAvg: "237.30" xref: MassMono: "237.147727" xref: Origin: "O" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00868 ! natural, non-standard encoded residue [Term] id: MOD:01188 name: N-ethyl iodoacetamide-d5 - site Y def: "modification from UniMod Isotopic label -" [PubMed:11710128, PubMed:12766232, PubMed:3155470, PubMed:957432, UniMod:212#Y] synonym: "N-ethyl iodoacetamide-d5" RELATED UniMod-description [] synonym: "NEIAA:2H(5)" RELATED PSI-MS-label [] xref: DiffAvg: "90.08" xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1" xref: DiffMono: "90.084148" xref: Formula: "C 13 (1)H 11 (2)H 5 N 2 O 3" xref: MassAvg: "253.15" xref: MassMono: "253.147476" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00562 ! N-ethyl iodoacetamide-d5 [Term] id: MOD:01189 name: N-ethyl iodoacetamide-d5 - site C def: "modification from UniMod Isotopic label -" [PubMed:12766232, UniMod:212#C] synonym: "N-ethyl iodoacetamide-d5" RELATED UniMod-description [] synonym: "NEIAA:2H(5)" RELATED PSI-MS-label [] xref: DiffAvg: "90.08" xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1" xref: DiffMono: "90.084148" xref: Formula: "C 7 (1)H 7 (2)H 5 N 2 O 2 S 1" xref: MassAvg: "193.09" xref: MassMono: "193.093332" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00562 ! N-ethyl iodoacetamide-d5 [Term] id: MOD:01190 name: dibromo def: "Modification from UniMod Chemical derivative. OBSOLETE because duplicate and redundant with MOD:01006. Remap to MOD:01006." [UniMod:534] synonym: "Dibromo" RELATED PSI-MS-label [] synonym: "Dibromo" RELATED UniMod-description [] xref: DiffAvg: "157.79" xref: DiffFormula: "Br 2 H -2" xref: DiffMono: "155.821024" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "Y" xref: Source: "none" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01191 name: N-ethyl iodoacetamide-d0 - site C def: "modification from UniMod Isotopic label -" [PubMed:12766232, UniMod:211#C] synonym: "N-ethyl iodoacetamide-d0" RELATED UniMod-description [] synonym: "NEIAA" RELATED PSI-MS-label [] xref: DiffAvg: "85.11" xref: DiffFormula: "C 4 H 7 N 1 O 1" xref: DiffMono: "85.052764" xref: Formula: "C 7 H 12 N 2 O 2 S 1" xref: MassAvg: "188.25" xref: MassMono: "188.061949" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00561 ! N-ethyl iodoacetamide-d0 [Term] id: MOD:01192 name: N-ethyl iodoacetamide-d0 - site Y def: "modification from UniMod Isotopic label -" [PubMed:11760118, PubMed:12766232, UniMod:211#Y] synonym: "N-ethyl iodoacetamide-d0" RELATED UniMod-description [] synonym: "NEIAA" RELATED PSI-MS-label [] xref: DiffAvg: "85.11" xref: DiffFormula: "C 4 H 7 N 1 O 1" xref: DiffMono: "85.052764" xref: Formula: "C 13 H 16 N 2 O 3" xref: MassAvg: "248.28" xref: MassMono: "248.116092" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00561 ! N-ethyl iodoacetamide-d0 [Term] id: MOD:01193 name: phosphorylation to pyridyl thiol - site T def: "modification from UniMod Chemical derivative -" [PubMed:1093385, UniMod:264#T] synonym: "PET" RELATED PSI-MS-label [] synonym: "phosphorylation to pyridyl thiol" RELATED UniMod-description [] xref: DiffAvg: "121.20" xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1" xref: DiffMono: "121.035006" xref: Formula: "C 11 H 14 N 2 O 1 S 1" xref: MassAvg: "222.31" xref: MassMono: "222.082684" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00586 ! phosphorylation to pyridyl thiol [Term] id: MOD:01194 name: phosphorylation to pyridyl thiol - site S def: "modification from UniMod Chemical derivative -" [PubMed:15279557, UniMod:264#S] synonym: "PET" RELATED PSI-MS-label [] synonym: "phosphorylation to pyridyl thiol" RELATED UniMod-description [] xref: DiffAvg: "121.20" xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1" xref: DiffMono: "121.035006" xref: Formula: "C 10 H 12 N 2 O 1 S 1" xref: MassAvg: "208.28" xref: MassMono: "208.067034" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00586 ! phosphorylation to pyridyl thiol [Term] id: MOD:01195 name: benzoyl labeling reagent light form - site K def: "modification from UniMod Isotopic label -" [PubMed:11813307, PubMed:12777388, PubMed:15456300, UniMod:136#K] synonym: "Benzoyl" RELATED PSI-MS-label [] synonym: "labeling reagent light form (N-term & K)" RELATED UniMod-description [] xref: DiffAvg: "104.11" xref: DiffFormula: "C 7 H 4 O 1" xref: DiffMono: "104.026215" xref: Formula: "C 13 H 16 N 2 O 2" xref: MassAvg: "232.28" xref: MassMono: "232.121178" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00505 ! benzoyl labeling reagent light form (N-term and K) [Term] id: MOD:01196 name: 5-dimethylaminonaphthalene-1-sulfonyl - site K def: "OBSOLETE because redundant, replaced with MOD:01654. Remap to MOD:01654." [UniMod:139] synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] synonym: "Dansyl" RELATED PSI-MS-label [] xref: DiffAvg: "233.29" xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" xref: DiffMono: "233.051050" xref: Formula: "C 18 H 23 N 3 O 3 S 1" xref: MassAvg: "361.46" xref: MassMono: "361.146013" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01197 name: N-heptosyl-L-glutamine def: "A protein modification that effectively converts an L-glutamine residue to N-heptosyl-L-glutamine." [UniMod:490#Q] comment: From UniMod with no citation [JSG]. synonym: "Hep" RELATED PSI-MS-label [] synonym: "Heptose" RELATED UniMod-description [] xref: DiffAvg: "192.17" xref: DiffFormula: "C 7 H 12 O 6" xref: DiffMono: "192.063388" xref: Formula: "C 12 H 20 N 2 O 8" xref: MassAvg: "320.30" xref: MassMono: "320.121966" xref: Origin: "Q" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00925 ! heptosylated residue [Term] id: MOD:01198 name: O-heptosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-heptosyl-L-serine." [UniMod:490#S] comment: From UniMod with no citation [JSG]. synonym: "Hep" RELATED PSI-MS-label [] synonym: "Heptose" RELATED UniMod-description [] xref: DiffAvg: "192.17" xref: DiffFormula: "C 7 H 12 O 6" xref: DiffMono: "192.063388" xref: Formula: "C 10 H 17 N 1 O 8" xref: MassAvg: "279.25" xref: MassMono: "279.095417" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00925 ! heptosylated residue [Term] id: MOD:01199 name: N-heptosyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to an N-heptosyl-L-arginine." [UniMod:490#R] comment: From UniMod with no citation [JSG]. synonym: "Hep" RELATED PSI-MS-label [] synonym: "Heptose" RELATED UniMod-description [] xref: DiffAvg: "192.17" xref: DiffFormula: "C 7 H 12 O 6" xref: DiffMono: "192.063388" xref: Formula: "C 13 H 24 N 4 O 7" xref: MassAvg: "348.36" xref: MassMono: "348.164499" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00925 ! heptosylated residue [Term] id: MOD:01200 name: O-heptosyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-heptosyl-L-threonine." [UniMod:490#T] comment: From UniMod with no citation [JSG]. synonym: "Hep" RELATED PSI-MS-label [] synonym: "Heptose" RELATED UniMod-description [] xref: DiffAvg: "192.17" xref: DiffFormula: "C 7 H 12 O 6" xref: DiffMono: "192.063388" xref: Formula: "C 11 H 19 N 1 O 8" xref: MassAvg: "293.27" xref: MassMono: "293.111067" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00925 ! heptosylated residue [Term] id: MOD:01201 name: N6-heptosyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-heptosyl-L-lysine." [UniMod:490#K] comment: From UniMod with no citation [JSG]. synonym: "Hep" RELATED PSI-MS-label [] synonym: "Heptose" RELATED UniMod-description [] xref: DiffAvg: "192.17" xref: DiffFormula: "C 7 H 12 O 6" xref: DiffMono: "192.063388" xref: Formula: "C 13 H 24 N 2 O 7" xref: MassAvg: "320.34" xref: MassMono: "320.158351" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00925 ! heptosylated residue [Term] id: MOD:01202 name: N-heptosyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N-heptosyl-L-asparagine." [UniMod:490#N] comment: From UniMod with no citation [JSG]. synonym: "Hep" RELATED PSI-MS-label [] synonym: "Heptose" RELATED UniMod-description [] xref: DiffAvg: "192.17" xref: DiffFormula: "C 7 H 12 O 6" xref: DiffMono: "192.063388" xref: Formula: "C 11 H 18 N 2 O 8" xref: MassAvg: "306.27" xref: MassMono: "306.106316" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00925 ! heptosylated residue [Term] id: MOD:01203 name: N6-(pyridylacetyl)lysine def: "A protein modification that effectively converts an L-lysine residue to N6-[(pyrid-3-yl)acetyl]lysine." [PubMed:9276974, UniMod:25#K] comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. synonym: "Pyridylacetyl" RELATED PSI-MS-label [] synonym: "pyridylacetyl" RELATED UniMod-description [] xref: DiffAvg: "119.12" xref: DiffFormula: "C 7 H 5 N 1 O 1" xref: DiffMono: "119.037114" xref: Formula: "C 13 H 17 N 3 O 2" xref: MassAvg: "247.30" xref: MassMono: "247.132077" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00418 ! pyridylacetylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01204 name: prompt loss of methanethiol from oxidixed methionine def: "modification from UniMod Artifact -" [PubMed:9004526, UniMod:526] synonym: "Dethiomethyl" RELATED PSI-MS-label [] synonym: "Prompt loss of side chain from oxidised Met" RELATED UniMod-description [] xref: DiffAvg: "-48.10" xref: DiffFormula: "C -1 H -4 S -1" xref: DiffMono: "-48.003371" xref: Formula: "C 4 H 5 N 1 O 1 S 0" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:01205 name: Hex1HexNAc1NeuAc2 O-glycosylated serine def: "A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [PubMed:7949339, UniMod:160#S] synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1NeuAc2" RELATED UniMod-description [] xref: DiffAvg: "947.85" xref: DiffFormula: "C 36 H 57 N 3 O 26" xref: DiffMono: "947.323029" xref: Formula: "C 39 H 62 N 4 O 28" xref: MassAvg: "1034.93" xref: MassMono: "1034.355057" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01206 name: Hex1HexNAc1NeuAc2 O-glycosylated threonine def: "A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [UniMod:160#T] synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1NeuAc2" RELATED UniMod-description [] xref: DiffAvg: "947.85" xref: DiffFormula: "C 36 H 57 N 3 O 26" xref: DiffMono: "947.323029" xref: Formula: "C 40 H 64 N 4 O 28" xref: MassAvg: "1048.95" xref: MassMono: "1048.370707" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01207 name: Hex1HexNAc1NeuAc2 N4-glycosylated asparagine def: "A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [UniMod:160#N] synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1NeuAc2" RELATED UniMod-description [] xref: DiffAvg: "947.85" xref: DiffFormula: "C 36 H 57 N 3 O 26" xref: DiffMono: "947.323029" xref: Formula: "C 40 H 63 N 5 O 28" xref: MassAvg: "1061.95" xref: MassMono: "1061.365956" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:01208 name: copper(1+) carboxylate C-terminal residue def: "A protein modification that effectively converts a C-terminal residue to the copper(1+) carboxylate salt." [UniMod:531#C-term] synonym: "Cation:Cu[I]" RELATED PSI-MS-label [] synonym: "cuprous salt" EXACT PSI-MOD-alternate [] synonym: "Replacement of proton by copper" RELATED UniMod-description [] xref: DiffAvg: "62.54" xref: DiffFormula: "Cu 1 H -1" xref: DiffMono: "61.921772" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "C-term" is_a: MOD:00742 ! copper containing modified residue [Term] id: MOD:01209 name: copper(1+) L-aspartate def: "A protein modification that effectively converts an L-aspartic acid residue to the copper(1+) aspartate salt." [UniMod:531#D] synonym: "Cation:Cu[I]" RELATED PSI-MS-label [] synonym: "cuprous salt" EXACT PSI-MOD-alternate [] synonym: "Replacement of proton by copper" RELATED UniMod-description [] xref: DiffAvg: "62.54" xref: DiffFormula: "Cu 1 H -1" xref: DiffMono: "61.921772" xref: Formula: "C 4 Cu 1 H 4 N 1 O 3" xref: MassAvg: "177.63" xref: MassMono: "176.948715" xref: Origin: "D" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00742 ! copper containing modified residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:01210 name: copper(1+) L-glutamate def: "A protein modification that effectively converts an L-glutamic acid residue to the copper(1+) glutamate salt." [UniMod:531#E] synonym: "Cation:Cu[I]" RELATED PSI-MS-label [] synonym: "cuprous salt" EXACT PSI-MOD-alternate [] synonym: "Replacement of proton by copper" RELATED UniMod-description [] xref: DiffAvg: "62.54" xref: DiffFormula: "Cu 1 H -1" xref: DiffMono: "61.921772" xref: Formula: "C 5 Cu 1 H 6 N 1 O 3" xref: MassAvg: "191.65" xref: MassMono: "190.964366" xref: Origin: "E" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00742 ! copper containing modified residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01211 name: N6-(morpholine-2-acetyl)-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-(morpholine-2-acetyl)-lysine." [PubMed:10446193, UniMod:29#K] comment: The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. synonym: "N-Succinimidyl-2-morpholine acetate" RELATED UniMod-description [] synonym: "N-succinimidylmorpholine-2-acetate N6-derivatized lysine" EXACT PSI-MOD-alternate [] synonym: "SMA" RELATED PSI-MS-label [] xref: DiffAvg: "127.14" xref: DiffFormula: "C 6 H 9 N 1 O 2" xref: DiffMono: "127.063329" xref: Formula: "C 12 H 21 N 3 O 3" xref: MassAvg: "255.32" xref: MassMono: "255.158292" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01813 ! morpholine-2-acetylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01212 name: iodoacetamide N6-derivatized lysine def: "A protein modification that effectively converts an L-lysine residue to N6-(carboxamidomethyl)lysine." [OMSSA:27, PubMed:11510821, PubMed:12422359, PubMed:12686488, UniMod:4#K] subset: PSI-MOD-slim synonym: "Carbamidomethyl" RELATED PSI-MS-label [] synonym: "carbamidomethylk" EXACT OMSSA-label [] synonym: "Iodoacetamide derivative" RELATED UniMod-description [] synonym: "N6-(2-amino-2-oxoethyl)lysine" EXACT PSI-MOD-alternate [] synonym: "N6-(carbamoylmethyl)lysine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1" xref: DiffMono: "57.021464" xref: Formula: "C 8 H 15 N 3 O 2" xref: MassAvg: "185.23" xref: MassMono: "185.116427" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01213 name: iodoacetamide derivatized histidine def: "A protein modification that effectively converts an L-histidine residue to an iodoacetamide derivatized histidine, either 1'- or 3'-(carboxamidolmethyl)histidine." [OMSSA:28, PubMed:11510821, PubMed:12422359, PubMed:15627961, PubMed:2026710, UniMod:4#H] subset: PSI-MOD-slim synonym: "Carbamidomethyl" RELATED PSI-MS-label [] synonym: "carbamidometylh" EXACT OMSSA-label [] synonym: "Iodoacetamide derivative" RELATED UniMod-description [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1" xref: DiffMono: "57.021464" xref: Formula: "C 8 H 10 N 4 O 2" xref: MassAvg: "194.19" xref: MassMono: "194.080376" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01214 name: iodoacetamide - site C def: "modification from UniMod Chemical derivative - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060." [PubMed:10504701, PubMed:11510821, PubMed:12422359, UniMod:4#C] synonym: "Carbamidomethyl" RELATED PSI-MS-label [] synonym: "Iodoacetamide derivative" RELATED UniMod-description [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1" xref: DiffMono: "57.021464" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01215 name: iodoacetamide derivatized aspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to O4-(carboxamidomethyl)aspartate." [OMSSA:29, PubMed:11510821, PubMed:12422359, PubMed:16526082, UniMod:4#D] subset: PSI-MOD-slim synonym: "Carbamidomethyl" RELATED PSI-MS-label [] synonym: "carbamidomethyld" EXACT OMSSA-label [] synonym: "Iodoacetamide derivative" RELATED UniMod-description [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1" xref: DiffMono: "57.021464" xref: Formula: "C 6 H 8 N 2 O 4" xref: MassAvg: "172.14" xref: MassMono: "172.048407" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:01216 name: iodoacetamide derivatized glutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to O5-(carboxamidomethyl)glutamate." [OMSSA:30, PubMed:11510821, PubMed:12422359, UniMod:4#E] subset: PSI-MOD-slim synonym: "Carbamidomethyl" RELATED PSI-MS-label [] synonym: "carbamidomethyle" EXACT OMSSA-label [] synonym: "Iodoacetamide derivative" RELATED UniMod-description [] xref: DiffAvg: "57.05" xref: DiffFormula: "C 2 H 3 N 1 O 1" xref: DiffMono: "57.021464" xref: Formula: "C 7 H 10 N 2 O 4" xref: MassAvg: "186.17" xref: MassMono: "186.064057" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01217 name: Sulfanilic Acid (SA), light C12 - site D def: "modification from UniMod Isotopic label -" [PubMed:12872131, UniMod:285#D] synonym: "Light Sulfanilic Acid (SA) C12" RELATED UniMod-description [] synonym: "SulfanilicAcid" RELATED PSI-MS-label [] xref: DiffAvg: "155.00" xref: DiffFormula: "(12)C 6 H 5 N 1 O 2 S 1" xref: DiffMono: "155.004099" xref: Formula: "(12)C 10 H 10 N 2 O 5 S 1" xref: MassAvg: "270.03" xref: MassMono: "270.031042" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00605 ! Sulfanilic Acid (SA), light C12 [Term] id: MOD:01218 name: Sulfanilic Acid (SA), light C12 - site E def: "modification from UniMod Isotopic label -" [PubMed:15283597, UniMod:285#E] synonym: "Light Sulfanilic Acid (SA) C12" RELATED UniMod-description [] synonym: "SulfanilicAcid" RELATED PSI-MS-label [] xref: DiffAvg: "155.00" xref: DiffFormula: "(12)C 6 H 5 N 1 O 2 S 1" xref: DiffMono: "155.004099" xref: Formula: "(12)C 11 H 12 N 2 O 5 S 1" xref: MassAvg: "284.05" xref: MassMono: "284.046692" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00605 ! Sulfanilic Acid (SA), light C12 [Term] id: MOD:01219 name: Sulfanilic Acid (SA), heavy C13 - site D def: "modification from UniMod Chemical derivative -" [PubMed:9254591, PubMed:9750125, UniMod:286#D] synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED UniMod-description [] synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "161.02" xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1" xref: DiffMono: "161.024228" xref: Formula: "(12)C 4 (13)C 6 H 10 N 2 O 5 S 1" xref: MassAvg: "276.05" xref: MassMono: "276.051171" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00606 ! Sulfanilic Acid (SA), heavy C13 [Term] id: MOD:01220 name: Sulfanilic Acid (SA), heavy C13 - site E def: "modification from UniMod Chemical derivative -" [PubMed:15121203, PubMed:9254591, UniMod:286#E] synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED UniMod-description [] synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "161.02" xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1" xref: DiffMono: "161.024228" xref: Formula: "(12)C 5 (13)C 6 H 12 N 2 O 5 S 1" xref: MassAvg: "290.07" xref: MassMono: "290.066822" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00606 ! Sulfanilic Acid (SA), heavy C13 [Term] id: MOD:01221 name: O-formyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-formyl-L-threonine." [PubMed:11861642, PubMed:15799070, UniMod:122#T] comment: From UniMod: Can occur under CNBr cleavage conditions (70% HCOOH). synonym: "Formyl" RELATED PSI-MS-label [] synonym: "Formylation" RELATED UniMod-description [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01483 ! O-formylated residue [Term] id: MOD:01222 name: O-formyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-formyl-L-serine." [PubMed:15627961, PubMed:15799070, UniMod:122#S] comment: From UniMod: Can occur under CNBr cleavage conditions (70% HCOOH). synonym: "Formyl" RELATED PSI-MS-label [] synonym: "Formylation" RELATED UniMod-description [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 4 H 5 N 1 O 3" xref: MassAvg: "115.09" xref: MassMono: "115.026943" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01483 ! O-formylated residue [Term] id: MOD:01223 name: thioacylation of primary amines - site N-term def: "modification from UniMod Other -" [OMSSA:41, PubMed:11710128, PubMed:3155470, PubMed:957432, UniMod:126#N-term] comment: This UniMod entry is misdescribed as "thioacylation" [JSG]. synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED UniMod-alternate [] synonym: "ntermpeptioacetyl" EXACT OMSSA-label [] synonym: "Thioacyl" RELATED PSI-MS-label [] synonym: "thioacylation of primary amines (N-term and Lys)" RELATED UniMod-description [] xref: DiffAvg: "88.12" xref: DiffFormula: "C 3 H 4 O 1 S 1" xref: DiffMono: "87.998286" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00497 ! 3-sulfanylpropanoyl (N-term and Lys) [Term] id: MOD:01224 name: thioacylation of primary amines - site K def: "modification from UniMod Other -" [OMSSA:40, PubMed:11710128, PubMed:3155470, PubMed:957432, UniMod:126#K] comment: This UniMod entry is misdescribed as "thioacylation" [JSG]. synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED UniMod-alternate [] synonym: "thioacetylk" EXACT OMSSA-label [] synonym: "Thioacyl" RELATED PSI-MS-label [] synonym: "thioacylation of primary amines (N-term and Lys)" RELATED UniMod-description [] xref: DiffAvg: "88.12" xref: DiffFormula: "C 3 H 4 O 1 S 1" xref: DiffMono: "87.998286" xref: Formula: "C 9 H 16 N 2 O 2 S 1" xref: MassAvg: "216.30" xref: MassMono: "216.093249" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00497 ! 3-sulfanylpropanoyl (N-term and Lys) [Term] id: MOD:01225 name: monofluorinated L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue into an L-fluorotyrosine." [OMSSA:46, PubMed:8069568, UniMod:127#Y] comment: From UniMod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. synonym: "Fluoro" RELATED PSI-MS-label [] synonym: "fluorophenylalanine replacement of phenylalanine" RELATED UniMod-description [] synonym: "phef" EXACT OMSSA-label [] xref: DiffAvg: "17.99" xref: DiffFormula: "F 1 H -1" xref: DiffMono: "17.990578" xref: Formula: "C 9 F 1 H 8 N 1 O 2" xref: MassAvg: "181.17" xref: MassMono: "181.053907" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00498 ! fluorinated residue is_a: MOD:00985 ! halogenated tyrosine [Term] id: MOD:01226 name: monofluorinated L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to an L-fluorotryptophan." [PubMed:8069568, UniMod:127#W] comment: From UniMod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. synonym: "Fluoro" RELATED PSI-MS-label [] synonym: "fluorophenylalanine replacement of phenylalanine" RELATED UniMod-description [] xref: DiffAvg: "17.99" xref: DiffFormula: "F 1 H -1" xref: DiffMono: "17.990578" xref: Formula: "C 11 F 1 H 9 N 2 O 1" xref: MassAvg: "204.20" xref: MassMono: "204.069891" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00498 ! fluorinated residue is_a: MOD:01068 ! halogenated tryptophan [Term] id: MOD:01227 name: monofluorinated L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to an L-fluorophenylalanine." [DeltaMass:181, OMSSA:46, PubMed:8069568, UniMod:127#F] comment: From UniMod: the citation appears to be correct, but the PMID is not and has been corrected. From DeltaMass: (element abbreviation in formula incorrect, mass incorrect, and aggregate not delta) Average Mass: 149 Formula: C9H8O1N1Fl1 Average Mass Change: 149 References:PE Sciex with no citation [JSG]. synonym: "Fluoro" RELATED PSI-MS-label [] synonym: "fluorophenylalanine replacement of phenylalanine" RELATED UniMod-description [] synonym: "phef" EXACT OMSSA-label [] xref: DiffAvg: "17.99" xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" xref: DiffMono: "17.990578" xref: Formula: "C 9 F 1 H 8 N 1 O 1" xref: MassAvg: "165.17" xref: MassMono: "165.058992" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00498 ! fluorinated residue is_a: MOD:01066 ! halogenated phenylalanine [Term] id: MOD:01228 name: monoiodinated tyrosine def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one iodine atom." [DeltaMass:0, OMSSA:65, PubMed:1326520, PubMed:15627961, PubMed:2026710, UniMod:129#Y] comment: From DeltaMass: Average Mass: 289 [name misspelled "monoiodated" - JSG]. subset: PSI-MOD-slim synonym: "I1Tyr" EXACT PSI-MOD-label [] synonym: "Iodination" RELATED UniMod-description [] synonym: "iodinationy" EXACT OMSSA-label [] synonym: "Iodo" RELATED PSI-MS-label [] xref: DiffAvg: "125.90" xref: DiffFormula: "H -1 I 1" xref: DiffMono: "125.896648" xref: Formula: "C 9 H 8 I 1 N 1 O 2" xref: MassAvg: "289.07" xref: MassMono: "288.959976" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00500 ! monoiodinated residue is_a: MOD:00998 ! iodinated tyrosine [Term] id: MOD:01229 name: L-iodohistidine def: "A protein modification that effectively converts an L-histidine residue to an L-iodohistidine." [PubMed:15627961, PubMed:2026710, UniMod:129#H] synonym: "I1His" EXACT PSI-MOD-label [] synonym: "Iodination" RELATED UniMod-description [] synonym: "Iodo" RELATED PSI-MS-label [] xref: DiffAvg: "125.90" xref: DiffFormula: "C 0 H -1 I 1 N 0 O 0" xref: DiffMono: "125.896648" xref: Formula: "C 6 H 6 I 1 N 3 O 1" xref: MassAvg: "263.04" xref: MassMono: "262.955560" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00500 ! monoiodinated residue is_a: MOD:01049 ! halogenated histidine [Term] id: MOD:01230 name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form - site K def: "modification from UniMod Isotopic label -" [PubMed:15602776, UniMod:365#K] synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form" RELATED UniMod-description [] synonym: "ICPL" RELATED PSI-MS-label [] xref: DiffAvg: "105.02" xref: DiffFormula: "(12)C 6 H 3 N 1 O 1" xref: DiffMono: "105.021464" xref: Formula: "(12)C 12 H 15 N 3 O 2" xref: MassAvg: "233.12" xref: MassMono: "233.116427" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00790 ! Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form [Term] id: MOD:01231 name: 3x(13)C labeled N6-propanoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 3x(13)C labeled N6-propanoyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:12442261, UniMod:59#K] subset: PSI-MOD-slim synonym: "Propionate labeling reagent heavy form (+3amu), N-term & K" RELATED UniMod-description [] synonym: "Propionyl:13C(3)" RELATED PSI-MS-label [] xref: DiffAvg: "59.04" xref: DiffFormula: "(13)C 3 H 4 O 1" xref: DiffMono: "59.036279" xref: Formula: "(12)C 6 (13)C 3 H 16 N 2 O 2" xref: MassAvg: "187.13" xref: MassMono: "187.131242" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01398 ! N6-propanoyl-L-lysine [Term] id: MOD:01232 name: 3x(12)C labeled N6-propanoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 3x(12)C labeled N6-propanoyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:58#K] subset: PSI-MOD-slim synonym: "Propionate labeling reagent light form (N-term & K)" RELATED UniMod-description [] synonym: "Propionyl" RELATED PSI-MS-label [] xref: DiffAvg: "56.03" xref: DiffFormula: "(12)C 3 H 4 O 1" xref: DiffMono: "56.026215" xref: Formula: "(12)C 9 H 16 N 2 O 2" xref: MassAvg: "184.12" xref: MassMono: "184.121178" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01398 ! N6-propanoyl-L-lysine [Term] id: MOD:01233 name: 3x(2)H labeled N6-acetyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled N6-acetyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:56#K] subset: PSI-MOD-slim synonym: "Acetate labeling reagent (N-term & K) (heavy form, +3amu)" RELATED UniMod-description [] synonym: "Acetyl:2H(3)" RELATED PSI-MS-label [] xref: DiffAvg: "45.03" xref: DiffFormula: "C 2 (1)H -1 (2)H 3 O 1" xref: DiffMono: "45.029395" xref: Formula: "C 8 (1)H 11 (2)H 3 N 2 O 2" xref: MassAvg: "173.12" xref: MassMono: "173.124358" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00064 ! N6-acetyl-L-lysine is_a: MOD:00449 ! acetate labeling reagent (N-term) (heavy form, +3amu) [Term] id: MOD:01234 name: (18)O monosubstituted L-serine def: "modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, UniMod:258#S] subset: PSI-MOD-slim synonym: "Label:18O(1)" RELATED PSI-MS-label [] synonym: "O18 Labeling" RELATED UniMod-description [] xref: DiffAvg: "2.00" xref: DiffFormula: "(16)O -1 (18)O 1" xref: DiffMono: "2.004246" xref: Formula: "C 3 H 5 N 1 (16)O 1 (18)O 1" xref: MassAvg: "89.04" xref: MassMono: "89.036275" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00581 ! (18)O monosubstituted residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01235 name: (18)O monosubstituted L-threonine def: "modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, PubMed:15549660, UniMod:258#T] subset: PSI-MOD-slim synonym: "Label:18O(1)" RELATED PSI-MS-label [] synonym: "O18 Labeling" RELATED UniMod-description [] xref: DiffAvg: "2.00" xref: DiffFormula: "(16)O -1 (18)O 1" xref: DiffMono: "2.004246" xref: Formula: "C 4 H 7 N 1 (16)O 1 (18)O 1" xref: MassAvg: "103.05" xref: MassMono: "103.051925" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00581 ! (18)O monosubstituted residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01236 name: (18)O monosubstituted L-tyrosine def: "modification from UniMod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, PubMed:15549660, UniMod:258#Y] subset: PSI-MOD-slim synonym: "Label:18O(1)" RELATED PSI-MS-label [] synonym: "O18 Labeling" RELATED UniMod-description [] xref: DiffAvg: "2.00" xref: DiffFormula: "(16)O -1 (18)O 1" xref: DiffMono: "2.004246" xref: Formula: "C 9 H 9 N 1 (16)O 1 (18)O 1" xref: MassAvg: "165.07" xref: MassMono: "165.067575" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00581 ! (18)O monosubstituted residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01237 name: cysteine 4-hydroxynonenal adduct def: "A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, PubMed:9629898, UniMod:53#C] comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. synonym: "4-hydroxynonenal (HNE)" RELATED UniMod-description [] synonym: "HNE" RELATED PSI-MS-label [] xref: DiffAvg: "156.22" xref: DiffFormula: "C 9 H 16 O 2" xref: DiffMono: "156.115030" xref: Formula: "C 12 H 21 N 1 O 3 S 1" xref: MassAvg: "259.36" xref: MassMono: "259.124215" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00446 ! 4-hydroxynonenal adduct [Term] id: MOD:01238 name: lysine 4-hydroxynonenal adduct def: "A protein modification produced by formation of an adduct of an L-lysine residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, PubMed:9629898, UniMod:53#K] comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. synonym: "4-hydroxynonenal (HNE)" RELATED UniMod-description [] synonym: "HNE" RELATED PSI-MS-label [] xref: DiffAvg: "156.22" xref: DiffFormula: "C 9 H 16 O 2" xref: DiffMono: "156.115030" xref: Formula: "C 15 H 28 N 2 O 3" xref: MassAvg: "284.40" xref: MassMono: "284.209993" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00446 ! 4-hydroxynonenal adduct [Term] id: MOD:01239 name: histidine 4-hydroxynonenal adduct def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal." [PubMed:10717661, PubMed:11327326, PubMed:15133838, UniMod:53#H] comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. synonym: "4-hydroxynonenal (HNE)" RELATED UniMod-description [] synonym: "HNE" RELATED PSI-MS-label [] xref: DiffAvg: "156.22" xref: DiffFormula: "C 9 H 16 O 2" xref: DiffMono: "156.115030" xref: Formula: "C 15 H 23 N 3 O 3" xref: MassAvg: "293.37" xref: MassMono: "293.173942" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00446 ! 4-hydroxynonenal adduct [Term] id: MOD:01240 name: ubiquitination signature tetrapeptidyl lysine def: "A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of leucyl-arginyl-glycyl-glycine, the C-terminal tetrapeptide of ubiquitin." [PubMed:10504701, UniMod:535] synonym: "LeuArgGlyGly" RELATED PSI-MS-label [] synonym: "Ubiquitination" RELATED UniMod-description [] xref: DiffAvg: "383.45" xref: DiffFormula: "C 16 H 29 N 7 O 4" xref: DiffMono: "383.228102" xref: Formula: "C 22 H 41 N 9 O 5" xref: MassAvg: "511.63" xref: MassMono: "511.323065" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01875 ! N6-acylated L-lysine relationship: derives_from MOD:01148 ! ubiquitinylated lysine [Term] id: MOD:01241 name: 3x(2)H labeled L-aspartic acid 4-methyl ester def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-aspartic acid 4-methyl ester." [OMSSA:19, PubMed:12185208, UniMod:298#D] synonym: "deuterated methyl ester" RELATED UniMod-description [] synonym: "Methyl:2H(3)" RELATED PSI-MS-label [] synonym: "trideuteromethyld" EXACT OMSSA-label [] xref: DiffAvg: "17.03" xref: DiffFormula: "C 1 (1)H -1 (2)H 3" xref: DiffMono: "17.034480" xref: Formula: "C 5 (1)H 4 (2)H 3 N 1 O 3" xref: MassAvg: "132.06" xref: MassMono: "132.061423" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00617 ! 3x(2)H residue methyl ester is_a: MOD:00904 ! modified L-aspartic acid residue relationship: derives_from MOD:01181 ! L-aspartic acid 4-methyl ester [Term] id: MOD:01242 name: 3x(2)H labeled L-glutamic acid 5-methyl ester def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-glutamic acid 5-methyl ester." [OMSSA:20, PubMed:1326520, UniMod:298#E] synonym: "deuterated methyl ester" RELATED UniMod-description [] synonym: "Methyl:2H(3)" RELATED PSI-MS-label [] synonym: "trideuteromethyle" EXACT OMSSA-label [] xref: DiffAvg: "17.03" xref: DiffFormula: "C 1 (1)H -1 (2)H 3" xref: DiffMono: "17.034480" xref: Formula: "C 6 (1)H 6 (2)H 3 N 1 O 3" xref: MassAvg: "146.08" xref: MassMono: "146.077073" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00617 ! 3x(2)H residue methyl ester is_a: MOD:00906 ! modified L-glutamic acid residue relationship: derives_from MOD:00081 ! L-glutamic acid 5-methyl ester (Glu) [Term] id: MOD:01243 name: potassium carboxylate C-terminal residue def: "A protein modification that effectively converts a C-terminal residue to the potassium carboxylate salt." [UniMod:530#C-term] synonym: "Cation:K" RELATED PSI-MS-label [] synonym: "Replacement of proton by potassium" RELATED UniMod-description [] xref: DiffAvg: "38.09" xref: DiffFormula: "H -1 K 1" xref: DiffMono: "37.955882" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "C-term" is_a: MOD:01072 ! monopotassium salt [Term] id: MOD:01244 name: potassium L-glutamate def: "A protein modification that effectively converts an L-glutamioc acid residue to the potassium glutamate salt." [UniMod:530#E] synonym: "Cation:K" RELATED PSI-MS-label [] synonym: "Replacement of proton by potassium" RELATED UniMod-description [] xref: DiffAvg: "38.09" xref: DiffFormula: "H -1 K 1" xref: DiffMono: "37.955882" xref: Formula: "C 5 H 6 K 1 N 1 O 3" xref: MassAvg: "167.21" xref: MassMono: "166.998475" xref: Origin: "E" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01072 ! monopotassium salt [Term] id: MOD:01245 name: potassium L-aspartate def: "A protein modification that effectively converts an L-aspartic acid residue to the potassium aspartate salt." [UniMod:530#D] synonym: "Cation:K" RELATED PSI-MS-label [] synonym: "Replacement of proton by potassium" RELATED UniMod-description [] xref: DiffAvg: "38.09" xref: DiffFormula: "H -1 K 1" xref: DiffMono: "37.955882" xref: Formula: "C 4 H 4 K 1 N 1 O 3" xref: MassAvg: "153.18" xref: MassMono: "152.982825" xref: Origin: "D" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01072 ! monopotassium salt [Term] id: MOD:01246 name: fucosylated -site S def: "OBSOLETE because redundant and identical to MOD:00812 after formula correction. Remap to MOD:00812." [PubMed:11344537, PubMed:15189151, PubMed:3311742, PubMed:3578767, UniMod:295#S] synonym: "dHex" RELATED PSI-MS-label [] synonym: "Fucose" RELATED UniMod-description [] xref: DiffAvg: "147.15" xref: DiffFormula: "C 6 H 11 O 4" xref: DiffMono: "147.065734" xref: Formula: "C 9 H 16 N 1 O 6" xref: MassAvg: "234.23" xref: MassMono: "234.097762" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01247 name: fucosylated -site T def: "OBSOLETE because redundant and identical to MOD:00813 after formula correction. Remap to MOD:00813." [PubMed:11344537, PubMed:11857757, PubMed:15189151, UniMod:295#T] synonym: "dHex" RELATED PSI-MS-label [] synonym: "Fucose" RELATED UniMod-description [] xref: DiffAvg: "147.15" xref: DiffFormula: "C 6 H 11 O 4" xref: DiffMono: "147.065734" xref: Formula: "C 10 H 18 N 1 O 6" xref: MassAvg: "248.26" xref: MassMono: "248.113412" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01248 name: iodouridine monophosphate derivatized tyrosine def: "A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tyrosine residue to form an ether linkage." [PubMed:11112526, PubMed:11567090, PubMed:6540775, UniMod:292#Y] comment: This has an ether linkage and not a phosphodiester linkage with UMP. synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED UniMod-description [] synonym: "IodoU-AMP" RELATED PSI-MS-label [] xref: DiffAvg: "322.17" xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1" xref: DiffMono: "322.020217" xref: Formula: "C 18 H 20 N 3 O 11 P 1" xref: MassAvg: "485.34" xref: MassMono: "485.083545" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00611 ! iodouridine monophosphate derivatized residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01249 name: iodouridine monophosphate derivatized tryptophan def: "A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tryptophan residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, UniMod:292#W] comment: This has a carbon-nitrogen linkage and not a phosphodiester linkage with UMP. synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED UniMod-description [] synonym: "IodoU-AMP" RELATED PSI-MS-label [] xref: DiffAvg: "322.17" xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1" xref: DiffMono: "322.020217" xref: Formula: "C 20 H 21 N 4 O 10 P 1" xref: MassAvg: "508.38" xref: MassMono: "508.099530" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00611 ! iodouridine monophosphate derivatized residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01250 name: iodouridine monophosphate derivatized phenylalanine def: "A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-phenylalanine residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, UniMod:292#F] comment: This has a carbon-carbon linkage and not a phosphodiester linkage with UMP. synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED UniMod-description [] synonym: "IodoU-AMP" RELATED PSI-MS-label [] xref: DiffAvg: "322.17" xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1" xref: DiffMono: "322.020217" xref: Formula: "C 18 H 20 N 3 O 10 P 1" xref: MassAvg: "469.34" xref: MassMono: "469.088630" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00611 ! iodouridine monophosphate derivatized residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:01251 name: N6-[3-(carboxamidomethylthio)propanoyl]lysine def: "A protein modification that effectively converts an L-lysine residue to N6-[3-(carboxamidomethylthio)propanoyl]lysine." [PubMed:15121203, UniMod:293#K] synonym: "3-(carbamidomethylthio)propanoyl" RELATED UniMod-description [] synonym: "CAMthiopropanoyl" RELATED PSI-MS-label [] xref: DiffAvg: "145.18" xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1" xref: DiffMono: "145.019749" xref: Formula: "C 11 H 19 N 3 O 3 S 1" xref: MassAvg: "273.35" xref: MassMono: "273.114712" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00612 ! 3-(carboxamidomethylthio)propanoylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01252 name: 5-hydro-5-methylimidazol-4-one, methylglyoxal arginine adduct (+54 amu) def: "OBSOLETE because redundant and identical to MOD:00933. Remap to MOD:00933." [PubMed:9448752, UniMod:319#R] synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label [] synonym: "MDA adduct +54" RELATED UniMod-description [] xref: DiffAvg: "54.05" xref: DiffFormula: "C 3 H 2 O 1" xref: DiffMono: "54.010565" xref: Formula: "C 9 H 14 N 4 O 2" xref: MassAvg: "210.24" xref: MassMono: "210.111676" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01253 name: malondialdehyde lysine adduct (+54 amu) def: "modification from UniMod Chemical derivative - Malondialdehyde (MDA) adduct" [UniMod:319#K] synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label [] synonym: "MDA adduct +54" RELATED UniMod-description [] xref: DiffAvg: "54.05" xref: DiffFormula: "C 3 H 2 O 1" xref: DiffMono: "54.010565" xref: Formula: "C 9 H 14 N 2 O 2" xref: MassAvg: "182.22" xref: MassMono: "182.105528" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00630 ! C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01254 name: 4x(2)H labeled dimethylated L-lysine def: "A protein modification that effectively converts an L-lysine residue to 4x(2)H labeled dimethylated L-lysine." [OMSSA:189, PubMed:14670044, UniMod:199#K] subset: PSI-MOD-slim synonym: "DiMethyl-CHD2" RELATED UniMod-description [] synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label [] synonym: "mod189" EXACT OMSSA-label [] xref: DiffAvg: "32.06" xref: DiffFormula: "C 2 (2)H 4" xref: DiffMono: "32.056407" xref: Formula: "C 8 H 12 (2)H 4 N 2 O 1" xref: MassAvg: "160.15" xref: MassMono: "160.151370" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00552 ! 4x(2)H labeled dimethylated residue is_a: MOD:00912 ! modified L-lysine residue relationship: derives_from MOD:00084 ! N6,N6-dimethyl-L-lysine [Term] id: MOD:01255 name: S-(2-sulfanylethyl)cysteine (Ser) def: "A protein modification that effectively converts an L-serine residue to S-(2-sulfanylethyl)cysteine." [PubMed:11507762, UniMod:200#S] synonym: "EDT" RELATED UniMod-description [] synonym: "Ethanedithiol" RELATED PSI-MS-label [] synonym: "S-(2-mercaptoethyl)cysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "76.18" xref: DiffFormula: "C 2 H 4 O -1 S 2" xref: DiffMono: "75.980528" xref: Formula: "C 5 H 9 N 1 O 1 S 2" xref: MassAvg: "163.25" xref: MassMono: "163.012556" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00553 ! 1,2-ethanedithiol modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01256 name: 3-methyl-S-(2-sulfanylethyl)cysteine (Thr) def: "A protein modification that effectively converts an L-threonine residue to 3-methyl-S-(2-sulfanylethyl)cysteine." [PubMed:11507762, UniMod:200#T] synonym: "beta-methyl-S-(2-mercaptoethyl)cysteine" EXACT PSI-MOD-alternate [] synonym: "EDT" RELATED UniMod-description [] synonym: "Ethanedithiol" RELATED PSI-MS-label [] xref: DiffAvg: "76.18" xref: DiffFormula: "C 2 H 4 O -1 S 2" xref: DiffMono: "75.980528" xref: Formula: "C 6 H 11 N 1 O 1 S 2" xref: MassAvg: "177.28" xref: MassMono: "177.028206" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00553 ! 1,2-ethanedithiol modified residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01257 name: 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate - site K def: "modification from UniMod Chemical derivative -" [PubMed:12716131, PubMed:14997490, UniMod:194#K] synonym: "6-aminoquinolyl-N-hydroxysuccinimidyl carbamate" RELATED UniMod-description [] synonym: "AccQTag" RELATED PSI-MS-label [] xref: DiffAvg: "170.17" xref: DiffFormula: "C 10 H 6 N 2 O 1" xref: DiffMono: "170.048013" xref: Formula: "C 16 H 18 N 4 O 2" xref: MassAvg: "298.35" xref: MassMono: "298.142976" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00547 ! 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate [Term] id: MOD:01258 name: N-methylmaleimide - site C def: "modification from UniMod Chemical derivative -" [PubMed:9448752, UniMod:314#C] synonym: "Nmethylmaleimide" RELATED PSI-MS-label [] synonym: "Nmethylmaleimide" RELATED UniMod-description [] xref: DiffAvg: "111.10" xref: DiffFormula: "C 5 H 5 N 1 O 2" xref: DiffMono: "111.032028" xref: Formula: "C 8 H 10 N 2 O 3 S 1" xref: MassAvg: "214.24" xref: MassMono: "214.041213" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00625 ! N-methylmaleimide derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01259 name: N-methylmaleimide - site K def: "modification from UniMod Chemical derivative -" [PubMed:9448752, UniMod:314#K] synonym: "Nmethylmaleimide" RELATED PSI-MS-label [] synonym: "Nmethylmaleimide" RELATED UniMod-description [] xref: DiffAvg: "111.10" xref: DiffFormula: "C 5 H 5 N 1 O 2" xref: DiffMono: "111.032028" xref: Formula: "C 11 H 17 N 3 O 3" xref: MassAvg: "239.27" xref: MassMono: "239.126991" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00625 ! N-methylmaleimide derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01260 name: nucleophilic addtion to cytopiloyne - site Y def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#Y] synonym: "Cytopiloyne" RELATED PSI-MS-label [] synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] xref: DiffAvg: "362.38" xref: DiffFormula: "C 19 H 22 O 7" xref: DiffMono: "362.136553" xref: Formula: "C 28 H 31 N 1 O 9" xref: MassAvg: "525.55" xref: MassMono: "525.199882" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01261 name: nucleophilic addtion to cytopiloyne - site S def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#C] synonym: "Cytopiloyne" RELATED PSI-MS-label [] synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] xref: DiffAvg: "362.38" xref: DiffFormula: "C 19 H 22 O 7" xref: DiffMono: "362.136553" xref: Formula: "C 22 H 27 N 1 O 9" xref: MassAvg: "449.46" xref: MassMono: "449.168581" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01262 name: nucleophilic addtion to cytopiloyne - site R def: "modification from UniMod Chemical derivative -" [PubMed:12590383, PubMed:15549660, UniMod:270#R] synonym: "Cytopiloyne" RELATED PSI-MS-label [] synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] xref: DiffAvg: "362.38" xref: DiffFormula: "C 19 H 22 O 7" xref: DiffMono: "362.136553" xref: Formula: "C 25 H 34 N 4 O 8" xref: MassAvg: "518.57" xref: MassMono: "518.237664" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:01263 name: nucleophilic addtion to cytopiloyne - site K def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#K] synonym: "Cytopiloyne" RELATED PSI-MS-label [] synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] xref: DiffAvg: "362.38" xref: DiffFormula: "C 19 H 22 O 7" xref: DiffMono: "362.136553" xref: Formula: "C 25 H 34 N 2 O 8" xref: MassAvg: "490.55" xref: MassMono: "490.231516" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01264 name: nucleophilic addtion to cytopiloyne - site C def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#C] synonym: "Cytopiloyne" RELATED PSI-MS-label [] synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] xref: DiffAvg: "362.38" xref: DiffFormula: "C 19 H 22 O 7" xref: DiffMono: "362.136553" xref: Formula: "C 22 H 27 N 1 O 8 S 1" xref: MassAvg: "465.52" xref: MassMono: "465.145738" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01265 name: nucleophilic addtion to cytopiloyne - site P def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:270#P] synonym: "Cytopiloyne" RELATED PSI-MS-label [] synonym: "nucleophilic addtion to cytopiloyne" RELATED UniMod-description [] xref: DiffAvg: "362.38" xref: DiffFormula: "C 19 H 22 O 7" xref: DiffMono: "362.136553" xref: Formula: "C 24 H 29 N 1 O 8" xref: MassAvg: "459.50" xref: MassMono: "459.189317" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00590 ! nucleophilic addtion to cytopiloyne is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:01266 name: nucleophilic addition to cytopiloyne+H2O - site C def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:271#C] synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] xref: DiffAvg: "380.39" xref: DiffFormula: "C 19 H 24 O 8" xref: DiffMono: "380.147118" xref: Formula: "C 22 H 29 N 1 O 9 S 1" xref: MassAvg: "483.53" xref: MassMono: "483.156303" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01267 name: nucleophilic addition to cytopiloyne+H2O - site K def: "modification from UniMod Chemical derivative -" [PubMed:11746907, PubMed:15549660, UniMod:271#K] synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] xref: DiffAvg: "380.39" xref: DiffFormula: "C 19 H 24 O 8" xref: DiffMono: "380.147118" xref: Formula: "C 25 H 36 N 2 O 9" xref: MassAvg: "508.57" xref: MassMono: "508.242081" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01268 name: nucleophilic addition to cytopiloyne+H2O - site T def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:271#T] synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] xref: DiffAvg: "380.39" xref: DiffFormula: "C 19 H 24 O 8" xref: DiffMono: "380.147118" xref: Formula: "C 23 H 31 N 1 O 10" xref: MassAvg: "481.50" xref: MassMono: "481.194796" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01269 name: nucleophilic addition to cytopiloyne+H2O - site R def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:271#R] synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] xref: DiffAvg: "380.39" xref: DiffFormula: "C 19 H 24 O 8" xref: DiffMono: "380.147118" xref: Formula: "C 25 H 36 N 4 O 9" xref: MassAvg: "536.58" xref: MassMono: "536.248229" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:01270 name: nucleophilic addition to cytopiloyne+H2O - site S def: "modification from UniMod Chemical derivative -" [PubMed:14670044, PubMed:15549660, UniMod:271#S] synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] xref: DiffAvg: "380.39" xref: DiffFormula: "C 19 H 24 O 8" xref: DiffMono: "380.147118" xref: Formula: "C 22 H 29 N 1 O 10" xref: MassAvg: "467.47" xref: MassMono: "467.179146" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01271 name: nucleophilic addition to cytopiloyne+H2O - site Y def: "modification from UniMod Chemical derivative -" [PubMed:15549660, UniMod:271#Y] synonym: "Cytopiloyne+water" RELATED PSI-MS-label [] synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED UniMod-description [] xref: DiffAvg: "380.39" xref: DiffFormula: "C 19 H 24 O 8" xref: DiffMono: "380.147118" xref: Formula: "C 28 H 33 N 1 O 10" xref: MassAvg: "543.57" xref: MassMono: "543.210446" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00591 ! nucleophilic addition to cytopiloyne+H2O is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01272 name: iminobiotinylation - site K def: "modification from UniMod Chemical derivative -" [PubMed:9750125, UniMod:89#K] synonym: "Iminobiotin" RELATED PSI-MS-label [] synonym: "Iminobiotinylation" RELATED UniMod-description [] xref: DiffAvg: "225.31" xref: DiffFormula: "C 10 H 15 N 3 O 1 S 1" xref: DiffMono: "225.093583" xref: Formula: "C 16 H 27 N 5 O 2 S 1" xref: MassAvg: "353.49" xref: MassMono: "353.188546" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00467 ! iminobiotinyl modified residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01273 name: O-[4-(2-aminoethyl)benzenesulfonyl] serine def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-serine residue." [PubMed:15283597, PubMed:8597590, UniMod:276#S] synonym: "AEBS" RELATED PSI-MS-label [] synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] xref: DiffAvg: "183.23" xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" xref: DiffMono: "183.035400" xref: Formula: "C 11 H 14 N 2 O 4 S 1" xref: MassAvg: "270.30" xref: MassMono: "270.067428" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01274 name: N'-[4-(2-aminoethyl)benzenesulfonyl] derivatized histidine def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-histidine residue." [PubMed:8597590, UniMod:276#H] synonym: "AEBS" RELATED PSI-MS-label [] synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] xref: DiffAvg: "183.23" xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" xref: DiffMono: "183.035400" xref: Formula: "C 14 H 16 N 4 O 3 S 1" xref: MassAvg: "320.37" xref: MassMono: "320.094311" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01275 name: N6-[4-(2-aminoethyl)benzenesulfonyl]lysine def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-lysine residue." [PubMed:8597590, UniMod:276#K] synonym: "AEBS" RELATED PSI-MS-label [] synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] xref: DiffAvg: "183.23" xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" xref: DiffMono: "183.035400" xref: Formula: "C 14 H 21 N 3 O 3 S 1" xref: MassAvg: "311.40" xref: MassMono: "311.130363" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01276 name: O4'-[4-(2-aminoethyl)benzenesulfonyl]tyrosine def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-tyrosine residue." [PubMed:10906242, PubMed:8597590, UniMod:276#Y] synonym: "AEBS" RELATED PSI-MS-label [] synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] xref: DiffAvg: "183.23" xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" xref: DiffMono: "183.035400" xref: Formula: "C 17 H 18 N 2 O 4 S 1" xref: MassAvg: "346.40" xref: MassMono: "346.098728" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01277 name: crotonaldehyde - site C def: "modification from UniMod Other -" [PubMed:11283024, UniMod:253#C] synonym: "Crotonaldehyde" RELATED PSI-MS-label [] synonym: "Crotonaldehyde" RELATED UniMod-description [] xref: DiffAvg: "70.09" xref: DiffFormula: "C 4 H 6 O 1" xref: DiffMono: "70.041865" xref: Formula: "C 7 H 11 N 1 O 2 S 1" xref: MassAvg: "173.23" xref: MassMono: "173.051050" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00576 ! crotonaldehyde is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01278 name: crotonaldehyde - site K def: "modification from UniMod Other -" [PubMed:11283024, UniMod:253#K] synonym: "Crotonaldehyde" RELATED PSI-MS-label [] synonym: "Crotonaldehyde" RELATED UniMod-description [] xref: DiffAvg: "70.09" xref: DiffFormula: "C 4 H 6 O 1" xref: DiffMono: "70.041865" xref: Formula: "C 10 H 18 N 2 O 2" xref: MassAvg: "198.27" xref: MassMono: "198.136828" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00576 ! crotonaldehyde is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01279 name: crotonaldehyde - site H def: "modification from UniMod Other -" [PubMed:11283024, PubMed:1443554, UniMod:253#H] synonym: "Crotonaldehyde" RELATED PSI-MS-label [] synonym: "Crotonaldehyde" RELATED UniMod-description [] xref: DiffAvg: "70.09" xref: DiffFormula: "C 4 H 6 O 1" xref: DiffMono: "70.041865" xref: Formula: "C 10 H 13 N 3 O 2" xref: MassAvg: "207.23" xref: MassMono: "207.100777" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00576 ! crotonaldehyde is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01280 name: EDT-iodo-PEO-biotin - site T def: "modification from UniMod Chemical derivative -" [PubMed:11857757, PubMed:12175151, UniMod:118#T] synonym: "EDT-iodo-PEO-biotin" RELATED UniMod-description [] synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label [] xref: DiffAvg: "490.70" xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3" xref: DiffMono: "490.174219" xref: Formula: "C 24 H 41 N 5 O 6 S 3" xref: MassAvg: "591.80" xref: MassMono: "591.221897" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00490 ! EDT-iodo-PEO-biotin is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01281 name: EDT-iodo-PEO-biotin - site S def: "modification from UniMod Chemical derivative -" [PubMed:16335955, UniMod:118#S] synonym: "EDT-iodo-PEO-biotin" RELATED UniMod-description [] synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label [] xref: DiffAvg: "490.70" xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3" xref: DiffMono: "490.174219" xref: Formula: "C 23 H 39 N 5 O 6 S 3" xref: MassAvg: "577.77" xref: MassMono: "577.206247" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00490 ! EDT-iodo-PEO-biotin is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01282 name: acrolein addition +56 - site H def: "modification from UniMod Other -" [PubMed:10825247, PubMed:15541752, UniMod:206#H] synonym: "Acrolein addition +56" RELATED UniMod-description [] synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label [] xref: DiffAvg: "56.06" xref: DiffFormula: "C 3 H 4 O 1" xref: DiffMono: "56.026215" xref: Formula: "C 9 H 11 N 3 O 2" xref: MassAvg: "193.21" xref: MassMono: "193.085127" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00557 ! acrolein addition +56 is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01283 name: acrolein addition +56 - site K def: "modification from UniMod Other -" [PubMed:10825247, PubMed:15541752, UniMod:206#K] synonym: "Acrolein addition +56" RELATED UniMod-description [] synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label [] xref: DiffAvg: "56.06" xref: DiffFormula: "C 3 H 4 O 1" xref: DiffMono: "56.026215" xref: Formula: "C 9 H 16 N 2 O 2" xref: MassAvg: "184.24" xref: MassMono: "184.121178" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00557 ! acrolein addition +56 is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01284 name: acrolein addition +56 - site C def: "modification from UniMod Other -" [PubMed:10825247, PubMed:15541752, PubMed:9254591, UniMod:206#C] synonym: "Acrolein addition +56" RELATED UniMod-description [] synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label [] xref: DiffAvg: "56.06" xref: DiffFormula: "C 3 H 4 O 1" xref: DiffMono: "56.026215" xref: Formula: "C 6 H 9 N 1 O 2 S 1" xref: MassAvg: "159.20" xref: MassMono: "159.035400" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00557 ! acrolein addition +56 is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01285 name: 6x(13)C,1x(15)N labeled L-leucine def: "A protein modification that effectively converts an L-leucine residue to 6x(13)C,1x(15)N isotope labeled L-leucine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:695#L] synonym: "13C(6) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "7.02" xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1" xref: DiffMono: "7.017164" xref: Formula: "(13)C 6 H 11 (15)N 1 O 1" xref: MassAvg: "120.10" xref: MassMono: "120.101228" xref: Origin: "L" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00911 ! modified L-leucine residue is_a: MOD:01370 ! 6x(13)C,1x(15)N labeled residue [Term] id: MOD:01286 name: 6x(13)C,1x(15)N labeled L-isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to 6x(13)C,1x(15)N isotope labeled L-isoleucine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:695#I] synonym: "13C(6) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "7.02" xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1" xref: DiffMono: "7.017164" xref: Formula: "(13)C 6 H 11 (15)N 1 O 1" xref: MassAvg: "120.10" xref: MassMono: "120.101228" xref: Origin: "I" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00910 ! modified L-isoleucine residue is_a: MOD:01370 ! 6x(13)C,1x(15)N labeled residue [Term] id: MOD:01287 name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form - site K def: "modification from UniMod Isotopic label -" [PubMed:11857757, PubMed:15602776, UniMod:364#K] synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form" RELATED UniMod-description [] synonym: "ICPL:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "111.04" xref: DiffFormula: "(13)C 6 H 3 N 1 O 1" xref: DiffMono: "111.041593" xref: Formula: "C 6 (13)C 6 H 15 N 3 O 2" xref: MassAvg: "239.14" xref: MassMono: "239.136556" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00789 ! Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01288 name: acetaldehyde +28 - site H def: "modification from UniMod Other -" [UniMod:255#H] synonym: "Acetaldehyde +28" RELATED UniMod-description [] synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 11 N 3 O 1" xref: MassAvg: "165.20" xref: MassMono: "165.090212" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00578 ! acetaldehyde +28 is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01289 name: acetaldehyde +28 - site K def: "modification from UniMod Other -" [UniMod:255#K] synonym: "Acetaldehyde +28" RELATED UniMod-description [] synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 16 N 2 O 1" xref: MassAvg: "156.23" xref: MassMono: "156.126263" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00578 ! acetaldehyde +28 is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01290 name: dihydroxylated residue - site F def: "OBSOLETE because redundant and identical to MOD:00465. Remap to MOD:00465." [PubMed:11857757, PubMed:12175151, PubMed:12686488, PubMed:9252331, UniMod:425] synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "O 2" xref: DiffMono: "31.989829" xref: Formula: "C 9 H 9 N 1 O 3" xref: MassAvg: "179.17" xref: MassMono: "179.058243" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01291 name: dihydroxylated residue - site W def: "OBSOLETE because redundant and identical to MOD:00464. Remap to MOD:00464." [PubMed:12643539, PubMed:12686488, PubMed:6273432, PubMed:9252331, UniMod:425] synonym: "dihydroxy" RELATED UniMod-description [] synonym: "Dioxidation" RELATED PSI-MS-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "O 2" xref: DiffMono: "31.989829" xref: Formula: "C 11 H 10 N 2 O 3" xref: MassAvg: "218.21" xref: MassMono: "218.069142" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01292 name: dimethylation of proline residue def: "OBSOLETE because redundant and identical to MOD:00075. Map to MOD:00075." [UniMod:529] synonym: "Delta:H(5)C(2)" RELATED PSI-MS-label [] synonym: "Dimethylation of proline residue" RELATED UniMod-description [] xref: DiffAvg: "29.06" xref: DiffFormula: "C 2 H 5" xref: DiffMono: "29.039125" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01293 name: 1x(18)O labeled deamidated L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O." [OMSSA:139, PubMed:8382902, UniMod:366#N] subset: PSI-MOD-slim synonym: "Deamidated:18O(1)" RELATED PSI-MS-label [] synonym: "Deamidation in presence of O18" RELATED UniMod-description [] synonym: "oxy18" EXACT OMSSA-label [] xref: DiffAvg: "2.99" xref: DiffFormula: "H -1 N -1 (18)O 1" xref: DiffMono: "2.988262" xref: Formula: "C 4 H 5 N 1 (16)O 2 (18)O 1" xref: MassAvg: "117.03" xref: MassMono: "117.031189" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00852 ! 1x(18)O labeled deamidated residue relationship: derives_from MOD:00684 ! deamidated L-asparagine [Term] id: MOD:01294 name: deamidation in presence of O18 -site Q def: "OBSOLETE identical and redundant with MOD:00791. Remap to MOD:00791." [PubMed:8382902] synonym: "Deamidated:18O(1)" RELATED PSI-MS-label [] synonym: "Deamidation in presence of O18" RELATED UniMod-description [] xref: DiffAvg: "2.99" xref: DiffFormula: "H -1 N -1 (18)O 1" xref: DiffMono: "2.988262" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "Q" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01295 name: monosodium L-aspartate def: "A protein modification that effectively converts an L-aspartic acid residue to monosodium L-aspartate." [PubMed:12216740, UniMod:30#D] subset: PSI-MOD-slim synonym: "Cation:Na" RELATED PSI-MS-label [] synonym: "Na1Asp" EXACT PSI-MOD-label [] synonym: "Sodium adduct" RELATED UniMod-description [] xref: DiffAvg: "21.98" xref: DiffFormula: "H -1 Na 1" xref: DiffMono: "21.981944" xref: Formula: "C 4 H 4 N 1 Na 1 O 3" xref: MassAvg: "137.07" xref: MassMono: "137.008887" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00423 ! monosodium salt is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:01296 name: monosodium L-glutamate def: "A protein modification that effectively converts an L-glutamic acid residue to monosodium L-glutamate." [PubMed:12216740, UniMod:30#E] subset: PSI-MOD-slim synonym: "Cation:Na" RELATED PSI-MS-label [] synonym: "MSG" EXACT PSI-MOD-alternate [] synonym: "Na1Glu" EXACT PSI-MOD-label [] synonym: "Sodium adduct" RELATED UniMod-description [] xref: DiffAvg: "21.98" xref: DiffFormula: "H -1 Na 1" xref: DiffMono: "21.981944" xref: Formula: "C 5 H 6 N 1 Na 1 O 3" xref: MassAvg: "151.10" xref: MassMono: "151.024537" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00423 ! monosodium salt is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01297 name: 5x(13)C labeled L-proline def: "A protein modification that effectively converts an L-proline residue to 5x(13)C labeled L-proline." [PubMed:12716131, UniMod:772#P] comment: In PubMed:12716131, fully (13)C labeled proline apparently resulted from the catabolic conversion of (13)C labeled L-arginine during SILAC. synonym: "13C(5) Silac label" RELATED UniMod-description [] synonym: "Label:13C(5)" RELATED PSI-MS-label [] xref: DiffAvg: "5.02" xref: DiffFormula: "(12)C -5 (13)C 5" xref: DiffMono: "5.016774" xref: Formula: "(13)C 5 H 7 N 1 O 1" xref: MassAvg: "102.07" xref: MassMono: "102.069538" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01832 ! 5x(13)C-labeled residue [Term] id: MOD:01298 name: reduced cysteine 4-hydroxynonenal adduct def: "A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:15133838, UniMod:335#C] comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label [] synonym: "reduced 4-Hydroxynonenal" RELATED UniMod-description [] xref: DiffAvg: "158.24" xref: DiffFormula: "C 9 H 18 O 2" xref: DiffMono: "158.130680" xref: Formula: "C 12 H 23 N 1 O 3 S 1" xref: MassAvg: "261.38" xref: MassMono: "261.139865" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct is_a: MOD:00905 ! modified L-cysteine residue relationship: derives_from MOD:01237 ! cysteine 4-hydroxynonenal adduct [Term] id: MOD:01299 name: reduced lysine 4-hydroxynonenal adduct def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:12148805, PubMed:15133838, UniMod:335#K] comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label [] synonym: "reduced 4-Hydroxynonenal" RELATED UniMod-description [] xref: DiffAvg: "158.24" xref: DiffFormula: "C 9 H 18 O 2" xref: DiffMono: "158.130680" xref: Formula: "C 15 H 30 N 2 O 3" xref: MassAvg: "286.42" xref: MassMono: "286.225643" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct is_a: MOD:00912 ! modified L-lysine residue relationship: derives_from MOD:01238 ! lysine 4-hydroxynonenal adduct [Term] id: MOD:01300 name: reduced histidine 4-hydroxynonenal adduct def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:12148805, PubMed:15133838, UniMod:335#H] comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label [] synonym: "reduced 4-Hydroxynonenal" RELATED UniMod-description [] xref: DiffAvg: "158.24" xref: DiffFormula: "C 9 H 18 O 2" xref: DiffMono: "158.130680" xref: Formula: "C 15 H 25 N 3 O 3" xref: MassAvg: "295.38" xref: MassMono: "295.189592" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct is_a: MOD:00909 ! modified L-histidine residue relationship: derives_from MOD:01239 ! histidine 4-hydroxynonenal adduct [Term] id: MOD:01301 name: methylamine Michael addition derivatized threonine def: "A protein modification that effectively converts an L-threonine residue to 2-amino-3-(methylamino)butanoic acid." [PubMed:11743741, UniMod:337#T] comment: In PubMed:11743741 phosphothreonine is converted to dehydrobutyrine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)butanoic acid. synonym: "Methylamine" RELATED PSI-MS-label [] synonym: "Michael addition with methylamine" RELATED UniMod-description [] xref: DiffAvg: "13.04" xref: DiffFormula: "C 1 H 3 N 1 O -1" xref: DiffMono: "13.031634" xref: Formula: "C 5 H 10 N 2 O 1" xref: MassAvg: "114.15" xref: MassMono: "114.079313" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00643 ! methylamine Michael addition derivatized residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01302 name: methylamine Michael addition derivatized serine def: "A protein modification that effectively converts an L-serine residue to 2-amino-3-(methylamino)propanoic acid." [PubMed:11743741, UniMod:337#S] comment: In PubMed:11743741 phosphoserine is converted to dehydroalanine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)propanoic acid. synonym: "Methylamine" RELATED PSI-MS-label [] synonym: "Michael addition with methylamine" RELATED UniMod-description [] xref: DiffAvg: "13.04" xref: DiffFormula: "C 1 H 3 N 1 O -1" xref: DiffMono: "13.031634" xref: Formula: "C 4 H 8 N 2 O 1" xref: MassAvg: "100.12" xref: MassMono: "100.063663" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00643 ! methylamine Michael addition derivatized residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01303 name: N4-hexosaminylated asparagine def: "A protein modification that effectively converts an L-asparagine residue to an N4-hexosaminyl-L-asparagine." [PubMed:11467524, UniMod:454#N] comment: The natural modifications are N4-(N-acetylamino)galactosyl-L-asparagine (MOD:00832) or N4-(N-acetylamino)glucosyl-L-asparagine (MOD:00831) [JSG]. synonym: "HexN" RELATED PSI-MS-label [] synonym: "Hexosamine" RELATED UniMod-description [] xref: DiffAvg: "161.16" xref: DiffFormula: "C 6 H 11 N 1 O 4" xref: DiffMono: "161.068808" xref: Formula: "C 10 H 17 N 3 O 6" xref: MassAvg: "275.26" xref: MassMono: "275.111735" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00160 ! N4-glycosyl-L-asparagine is_a: MOD:00876 ! hexosaminylated residue [Term] id: MOD:01304 name: N6-hexosaminylated lysine def: "A protein modification that effectively converts an L-lysine residue to an N4-hexosaminyl-L-lysine, as a synthetic peptide protectting group." [UniMod:454#K] synonym: "HexN" RELATED PSI-MS-label [] synonym: "Hexosamine" RELATED UniMod-description [] xref: DiffAvg: "161.16" xref: DiffFormula: "C 6 H 11 N 1 O 4" xref: DiffMono: "161.068808" xref: Formula: "C 12 H 23 N 3 O 5" xref: MassAvg: "289.33" xref: MassMono: "289.163771" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00876 ! hexosaminylated residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01305 name: N1'-hexosaminylated tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to N1'-hexosaminyl-L-tryptophan." [UniMod:454#W] comment: The natural modification is N1'-mannosyl-L-tryptophan (MOD:00165) [JSG]. synonym: "HexN" RELATED PSI-MS-label [] synonym: "Hexosamine" RELATED UniMod-description [] xref: DiffAvg: "161.16" xref: DiffFormula: "C 6 H 11 N 1 O 4" xref: DiffMono: "161.068808" xref: Formula: "C 17 H 21 N 3 O 5" xref: MassAvg: "347.37" xref: MassMono: "347.148121" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00876 ! hexosaminylated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01306 name: O-hexosaminylated threonine def: "A protein modification that effectively converts an L-threonine residue to O-hexosaminyl-L-threonine." [UniMod:454#T] comment: The natural modifications are O-(N-acetylaminogalactosyl)-L-threonine (MOD:00164) or O-(N-acetylaminoglucosyl)-L-threonine (MOD:00806) [JSG]. synonym: "HexN" RELATED PSI-MS-label [] synonym: "Hexosamine" RELATED UniMod-description [] xref: DiffAvg: "161.16" xref: DiffFormula: "C 6 H 11 N 1 O 4" xref: DiffMono: "161.068808" xref: Formula: "C 10 H 18 N 2 O 6" xref: MassAvg: "262.26" xref: MassMono: "262.116486" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00005 ! O-glycosyl-L-threonine is_a: MOD:00876 ! hexosaminylated residue [Term] id: MOD:01307 name: thiophosphate labeled with biotin-HPDP -site S def: "modification from UniMod Chemical derivative -" [UniMod:332#S] synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label [] synonym: "thiophosphate labeled with biotin-HPDP" RELATED UniMod-description [] xref: DiffAvg: "525.66" xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3" xref: DiffMono: "525.142895" xref: Formula: "C 22 H 39 N 5 O 7 P 1 S 3" xref: MassAvg: "612.74" xref: MassMono: "612.174923" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01308 name: thiophosphate labeled with biotin-HPDP -site T def: "modification from UniMod Chemical derivative -" [UniMod:332#T] synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label [] synonym: "thiophosphate labeled with biotin-HPDP" RELATED UniMod-description [] xref: DiffAvg: "525.66" xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3" xref: DiffMono: "525.142895" xref: Formula: "C 23 H 41 N 5 O 7 P 1 S 3" xref: MassAvg: "626.76" xref: MassMono: "626.190573" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01309 name: thiophosphate labeled with biotin-HPDP - site Y def: "modification from UniMod Chemical derivative - " [UniMod:332#Y] synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label [] synonym: "thiophosphate labeled with biotin-HPDP" RELATED UniMod-description [] xref: DiffAvg: "525.66" xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3" xref: DiffMono: "525.142895" xref: Formula: "C 28 H 43 N 5 O 7 P 1 S 3" xref: MassAvg: "688.83" xref: MassMono: "688.206223" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01310 name: quaternary amine labeling reagent light form N6-L-lysine def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent light form group." [PubMed:11857757, UniMod:60#K] synonym: "GIST-Quat" RELATED PSI-MS-label [] synonym: "Quaternary amine labeling reagent light form (N-term & K)" RELATED UniMod-description [] xref: DiffAvg: "59.07" xref: DiffFormula: "C 3 (1)H 9 N 1" xref: DiffMono: "59.073499" xref: Formula: "C 9 (1)H 21 N 3 O 1" xref: MassAvg: "187.17" xref: MassMono: "187.168462" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01311 name: quaternary amine labeling reagent heavy form (+3amu) N6-L-lysine def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+3amu) form group." [PubMed:11698400, PubMed:11857757, PubMed:11914093, UniMod:61#K] synonym: "GIST-Quat:2H(3)" RELATED PSI-MS-label [] synonym: "Quaternary amine labeling reagent heavy (+3amu) form, N-term & K" RELATED UniMod-description [] xref: DiffAvg: "62.09" xref: DiffFormula: "C 3 (1)H 6 (2)H 3 N 1" xref: DiffMono: "62.092330" xref: Formula: "C 9 (1)H 18 (2)H 3 N 3 O 1" xref: MassAvg: "190.19" xref: MassMono: "190.187293" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01312 name: quaternary amine labeling reagent heavy form (+6amu) N6-L-lysine def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+6amu) form group." [PubMed:11857757, UniMod:62#K] comment: Apparently incorrect parent [JSG]. synonym: "GIST-Quat:2H(6)" RELATED PSI-MS-label [] synonym: "Quaternary amine labeling reagent heavy form (+6amu), N-term & K" RELATED UniMod-description [] xref: DiffAvg: "65.11" xref: DiffFormula: "C 3 (1)H 3 (2)H 6 N 1" xref: DiffMono: "65.111160" xref: Formula: "C 9 (1)H 15 (2)H 6 N 3 O 1" xref: MassAvg: "193.21" xref: MassMono: "193.206123" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01313 name: quaternary amine labeling reagent heavy form (+9amu) N6-L-lysine def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+9amu) form group." [PubMed:11857757, UniMod:63#K] synonym: "GIST-Quat:2H(9)" RELATED PSI-MS-label [] synonym: "Quaternary amine labeling reagent heavy form (+9amu), N-term & K" RELATED UniMod-description [] xref: DiffAvg: "68.13" xref: DiffFormula: "C 3 (2)H 9 N 1" xref: DiffMono: "68.129990" xref: Formula: "C 9 (1)H 12 (2)H 9 N 3 O 1" xref: MassAvg: "196.22" xref: MassMono: "196.224953" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01314 name: 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine." [PubMed:11857757, PubMed:12175151, PubMed:12716131, UniMod:64#K] synonym: "Succinic anhydride labeling reagent light form (K)" RELATED UniMod-description [] synonym: "Succinyl" RELATED PSI-MS-label [] xref: DiffAvg: "100.02" xref: DiffFormula: "(12)C 4 (1)H 4 O 3" xref: DiffMono: "100.016044" xref: Formula: "(12)C 10 H 16 N 2 O 4" xref: MassAvg: "228.11" xref: MassMono: "228.111007" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue is_a: MOD:01819 ! N6-succinyl-L-lysine [Term] id: MOD:01315 name: 4x(2)H labeled N6-succinyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 4x(2)H-labeled N6-succinyl-L-lysine." [PubMed:11344537, PubMed:11857757, PubMed:12175151, PubMed:15189151, UniMod:65#K] synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term & K" RELATED UniMod-description [] synonym: "Succinyl:2H(4)" RELATED PSI-MS-label [] xref: DiffAvg: "104.04" xref: DiffFormula: "C 4 (2)H 4 O 3" xref: DiffMono: "104.041151" xref: Formula: "C 10 (1)H 12 (2)H 4 N 2 O 4" xref: MassAvg: "232.14" xref: MassMono: "232.136114" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01819 ! N6-succinyl-L-lysine [Term] id: MOD:01316 name: 4x(13)C labeled N6-succinyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 4x(13)C labeled N6-succinyl-L-lysine." [PubMed:11344537, PubMed:11857757, PubMed:12175151, PubMed:15189151, UniMod:66#K] synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), K" RELATED UniMod-description [] synonym: "Succinyl:13C(4)" RELATED PSI-MS-label [] xref: DiffAvg: "104.03" xref: DiffFormula: "(13)C 4 H 4 O 3" xref: DiffMono: "104.029463" xref: Formula: "(12)C 6 (13)C 4 H 16 N 2 O 4" xref: MassAvg: "232.12" xref: MassMono: "232.124426" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01819 ! N6-succinyl-L-lysine [Term] id: MOD:01317 name: phosphorylation to amine thiol - site T def: "modification from UniMod Chemical derivative -" [PubMed:12216740, UniMod:178#T] synonym: "DAET" RELATED PSI-MS-label [] synonym: "phosphorylation to amine thiol" RELATED UniMod-description [] xref: DiffAvg: "87.18" xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1" xref: DiffMono: "87.050656" xref: Formula: "C 8 H 16 N 2 O 1 S 1" xref: MassAvg: "188.29" xref: MassMono: "188.098334" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00535 ! phosphorylation to amine thiol is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01318 name: phosphorylation to amine thiol - site S def: "modification from UniMod Chemical derivative -" [PubMed:11510821, PubMed:12216740, PubMed:12422359, UniMod:178#S] synonym: "DAET" RELATED PSI-MS-label [] synonym: "phosphorylation to amine thiol" RELATED UniMod-description [] xref: DiffAvg: "87.18" xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1" xref: DiffMono: "87.050656" xref: Formula: "C 7 H 14 N 2 O 1 S 1" xref: MassAvg: "174.26" xref: MassMono: "174.082684" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00535 ! phosphorylation to amine thiol is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01319 name: Michael addition of BHT quinone methide to histidine def: "modification from UniMod Other" [PubMed:11510821, PubMed:12422359, PubMed:9448752, UniMod:176#H] comment: Secondary adduct, much less common than cysteine. [UniMod] synonym: "BHT" RELATED PSI-MS-label [] synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED UniMod-description [] xref: DiffAvg: "218.34" xref: DiffFormula: "C 15 H 22 O 1" xref: DiffMono: "218.167065" xref: Formula: "C 21 H 29 N 3 O 2" xref: MassAvg: "355.48" xref: MassMono: "355.225977" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01320 name: Michael addition of BHT quinone methide to lysine def: "modification from UniMod Other" [PubMed:16078144, PubMed:9448752, UniMod:176#K] comment: Secondary adduct, much less common than cysteine. [UniMod] synonym: "BHT" RELATED PSI-MS-label [] synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED UniMod-description [] xref: DiffAvg: "218.34" xref: DiffFormula: "C 15 H 22 O 1" xref: DiffMono: "218.167065" xref: Formula: "C 21 H 34 N 2 O 2" xref: MassAvg: "346.51" xref: MassMono: "346.262028" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01321 name: Michael addition of BHT quinone methide to cysteine def: "modification from UniMod Other" [PubMed:11510821, PubMed:12422359, PubMed:9448752, UniMod:176#C] comment: Primary adduct formed. [UniMod] synonym: "BHT" RELATED PSI-MS-label [] synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED UniMod-description [] xref: DiffAvg: "218.34" xref: DiffFormula: "C 15 H 22 O 1" xref: DiffMono: "218.167065" xref: Formula: "C 18 H 27 N 1 O 2 S 1" xref: MassAvg: "321.48" xref: MassMono: "321.176250" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01322 name: propionaldehyde +40 - site K def: "modification from UniMod Other -" [PubMed:15549660, UniMod:256#K] synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label [] synonym: "Propionaldehyde +40" RELATED UniMod-description [] xref: DiffAvg: "40.06" xref: DiffFormula: "C 3 H 4" xref: DiffMono: "40.031300" xref: Formula: "C 9 H 16 N 2 O 1" xref: MassAvg: "168.24" xref: MassMono: "168.126263" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00579 ! propionaldehyde +40 is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01323 name: propionaldehyde +40 - site H def: "modification from UniMod Other -" [UniMod:256#H] synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label [] synonym: "Propionaldehyde +40" RELATED UniMod-description [] xref: DiffAvg: "40.06" xref: DiffFormula: "C 3 H 4" xref: DiffMono: "40.031300" xref: Formula: "C 9 H 11 N 3 O 1" xref: MassAvg: "177.21" xref: MassMono: "177.090212" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00579 ! propionaldehyde +40 is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01324 name: acetaldehyde +26 - site H def: "modification from UniMod Other -" [PubMed:7744761, UniMod:254#H] synonym: "Acetaldehyde +26" RELATED UniMod-description [] synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "26.04" xref: DiffFormula: "C 2 H 2" xref: DiffMono: "26.015650" xref: Formula: "C 8 H 9 N 3 O 1" xref: MassAvg: "163.18" xref: MassMono: "163.074562" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00577 ! acetaldehyde +26 is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01325 name: acetaldehyde +26 - site K def: "modification from UniMod Other -" [PubMed:7744761, UniMod:254#K] synonym: "Acetaldehyde +26" RELATED UniMod-description [] synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "26.04" xref: DiffFormula: "C 2 H 2" xref: DiffMono: "26.015650" xref: Formula: "C 8 H 14 N 2 O 1" xref: MassAvg: "154.21" xref: MassMono: "154.110613" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00577 ! acetaldehyde +26 is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01326 name: 9x(13)C labeled L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-tyrosine." [PubMed:11510821, PubMed:12422359, PubMed:12716131, UniMod:184#Y] synonym: "13C(9) Silac label" RELATED UniMod-description [] synonym: "Label:13C(9)" RELATED PSI-MS-label [] xref: DiffAvg: "9.03" xref: DiffFormula: "(12)C -9 (13)C 9" xref: DiffMono: "9.030194" xref: Formula: "(13)C 9 H 9 N 1 O 2" xref: MassAvg: "172.09" xref: MassMono: "172.093522" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00540 ! 9x(13)C labeled residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01327 name: 9x(13)C labeled L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to 9x(13)C labeled L-phenylalanine." [PubMed:12716131, UniMod:184#F] synonym: "13C(9) Silac label" RELATED UniMod-description [] synonym: "Label:13C(9)" RELATED PSI-MS-label [] xref: DiffAvg: "9.03" xref: DiffFormula: "(12)C -9 (13)C 9" xref: DiffMono: "9.030194" xref: Formula: "(13)C 9 H 9 N 1 O 1" xref: MassAvg: "156.10" xref: MassMono: "156.098607" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00540 ! 9x(13)C labeled residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:01328 name: iodoacetic acid - site W def: "modification from UniMod Chemical derivative - hydroxylethanone" [PubMed:17525468, UniMod:6#W] comment: There is no citation for this UniMod entry. Iodoacetic acid derivatization of tryptophan is not mentioned in the citation [JSG]. synonym: "Carboxymethyl" RELATED PSI-MS-label [] synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 O 2" xref: DiffMono: "58.005479" xref: Formula: "C 13 H 12 N 2 O 3" xref: MassAvg: "244.25" xref: MassMono: "244.084792" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00399 ! iodoacetic acid derivatized residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01329 name: iodoacetic acid - site C def: "OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061" [DeltaMass:197] comment: Modification from UniMod Chemical derivative, UniMod:6 site C synonym: "Carboxymethyl" RELATED PSI-MS-label [] synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 O 2" xref: DiffMono: "58.005479" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01330 name: iodoacetic acid -site K def: "OBSOLETE because identical with MOD:01094. Remap to MOD:01094" [PubMed:18688235] comment: a modification from UniMod:6 synonym: "Carboxymethyl" RELATED PSI-MS-label [] synonym: "Iodoacetic acid derivative" RELATED UniMod-description [] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 O 2" xref: DiffMono: "58.005479" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01331 name: 6x(13)C labeled L-arginine def: "A protein modification that effectively converts an L-arginine residue to 6x(13)C labeled L-arginine." [OMSSA:136, PubMed:12716131, UniMod:188#R] subset: PSI-MOD-slim synonym: "13C(6) Silac label" RELATED UniMod-description [] synonym: "arg-13c6" EXACT OMSSA-label [] synonym: "Label:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "6.02" xref: DiffFormula: "(12)C -6 (13)C 6" xref: DiffMono: "6.020129" xref: Formula: "(13)C 6 H 12 N 4 O 1" xref: MassAvg: "162.12" xref: MassMono: "162.121240" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00544 ! 6x(13)C labeled residue [Term] id: MOD:01332 name: 6x(13)C labeled L-leucine def: "A protein modification that effectively converts an L-leucine residue to 6x(13)C labeled L-leucine." [PubMed:12716131, UniMod:188#L] subset: PSI-MOD-slim synonym: "13C(6) Silac label" RELATED UniMod-description [] synonym: "Label:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "6.02" xref: DiffFormula: "(12)C -6 (13)C 6" xref: DiffMono: "6.020129" xref: Formula: "(13)C 6 H 11 N 1 O 1" xref: MassAvg: "119.10" xref: MassMono: "119.104193" xref: Origin: "L" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00544 ! 6x(13)C labeled residue [Term] id: MOD:01333 name: 6x(13)C labeled L-isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to 6x(13)C labeled L-isoleucine." [PubMed:12716131, PubMed:12766232, UniMod:188#I] subset: PSI-MOD-slim synonym: "13C(6) Silac label" RELATED UniMod-description [] synonym: "Label:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "6.02" xref: DiffFormula: "(12)C -6 (13)C 6" xref: DiffMono: "6.020129" xref: Formula: "(13)C 6 H 11 N 1 O 1" xref: MassAvg: "119.10" xref: MassMono: "119.104193" xref: Origin: "I" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00544 ! 6x(13)C labeled residue [Term] id: MOD:01334 name: 6x(13)C labeled L-lysine def: "A protein modification that effectively converts an L-lysine residue to 6x(13)C labeled L-lysine." [OMSSA:138, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:12716131, UniMod:188#K] subset: PSI-MOD-slim synonym: "13C(6) Silac label" RELATED UniMod-description [] synonym: "Label:13C(6)" RELATED PSI-MS-label [] synonym: "lys-13c6" EXACT OMSSA-label [] xref: DiffAvg: "6.02" xref: DiffFormula: "(12)C -6 (13)C 6" xref: DiffMono: "6.020129" xref: Formula: "(13)C 6 H 12 N 2 O 1" xref: MassAvg: "134.12" xref: MassMono: "134.115092" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00544 ! 6x(13)C labeled residue [Term] id: MOD:01335 name: 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized lysine def: "modification from UniMod Chemical derivative -" [PubMed:11467524, PubMed:16526082, UniMod:464#K] synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED UniMod-description [] synonym: "SPITC:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "220.99" xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2" xref: DiffMono: "220.991214" xref: Formula: "(12)C 7 (13)C 6 H 17 N 3 O 4 S 2" xref: MassAvg: "349.09" xref: MassMono: "349.086177" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00880 ! 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01336 name: deamidation followed by a methylation -site Q def: "OBSOLETE - identical and redundant with MOD:00657. Remap to MOD:00657." [PubMed:18688235] comment: Modification from UniMod Post-translational - UniMod:528. synonym: "Deamidation followed by a methylation" RELATED UniMod-description [] synonym: "Methyl+Deamidated" RELATED PSI-MS-label [] xref: DiffAvg: "15.01" xref: DiffFormula: "C 1 H 1 N -1 O 1" xref: DiffMono: "14.999666" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01337 name: deamidated 4-methyl esterified asparagine def: "A protein modification that effectively converts an L-asparagine residue to L-aspartate 4-methyl ester." [UniMod:528#N] comment: The deamidation and methylation of L-asparagine has not been reported as a natural modification. It is extremely unlikely that eukaryotes produce this modification, because a natural process that would form L-aspartic acid 4-methyl ester from either L-aspartic acid or L-asparagine would interfere with the D-aspartyl peptide repair mechanism [JSG]. synonym: "Deamidation followed by a methylation" RELATED UniMod-description [] synonym: "Methyl+Deamidated" RELATED PSI-MS-label [] xref: DiffAvg: "15.01" xref: DiffFormula: "C 1 H 1 N -1 O 1" xref: DiffMono: "14.999666" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "N" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01181 ! L-aspartic acid 4-methyl ester is_a: MOD:01369 ! deamidated and methyl esterified residue [Term] id: MOD:01338 name: N6-ethyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-ethyl-L-lysine." [PubMed:9629898, UniMod:280#K] comment: The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. synonym: "Ethyl" RELATED PSI-MS-label [] synonym: "Ethylation" RELATED UniMod-description [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 16 N 2 O 1" xref: MassAvg: "156.23" xref: MassMono: "156.126263" xref: Origin: "K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01339 ! ethylated residue [Term] id: MOD:01339 name: ethylated residue def: "A protein modification that effectively replaces a hydrogen atom with an ethyl group." [PubMed:9629898, UniMod:280] comment: From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. synonym: "Ethyl" RELATED PSI-MS-label [] synonym: "Ethylation" RELATED UniMod-description [] synonym: "EtRes" EXACT PSI-MOD-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00001 ! alkylated residue [Term] id: MOD:01340 name: ESP-Tag heavy d10 - site K def: "modification from UniMod Isotopic label -" [PubMed:11078590, PubMed:11085420, PubMed:11821862, UniMod:91#K] synonym: "ESP-Tag heavy d10" RELATED UniMod-description [] synonym: "ESP:2H(10)" RELATED PSI-MS-label [] xref: DiffAvg: "348.24" xref: DiffFormula: "C 16 (1)H 16 (2)H 10 N 4 O 2 S 1" xref: DiffMono: "348.240415" xref: Formula: "C 22 (1)H 28 (2)H 10 N 6 O 3 S 1" xref: MassAvg: "476.34" xref: MassMono: "476.335378" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00469 ! ESP-Tag heavy d10 is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01341 name: ESP-Tag light d0 - site K def: "modification from UniMod Isotopic label -" [UniMod:90#K] synonym: "ESP" RELATED PSI-MS-label [] synonym: "ESP-Tag light d0" RELATED UniMod-description [] xref: DiffAvg: "338.47" xref: DiffFormula: "C 16 H 26 N 4 O 2 S 1" xref: DiffMono: "338.177647" xref: Formula: "C 22 H 38 N 6 O 3 S 1" xref: MassAvg: "466.64" xref: MassMono: "466.272610" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00468 ! ESP-Tag light d0 is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01342 name: selenium substitution for sulfur - site M def: "OBSOLETE because redundant and identical to MOD:00530. Remap to MOD:00530." [PubMed:12148805, UniMod:162] synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label [] synonym: "Selenium replaces sulphur" RELATED UniMod-description [] xref: DiffAvg: "46.91" xref: DiffFormula: "S -1 Se 1" xref: DiffMono: "47.944450" xref: Formula: "C 5 H 9 N 1 O 1 S 0 Se 1" xref: MassAvg: "178.10" xref: MassMono: "178.984935" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01343 name: selenium substitution for sulfur - site C def: "OBSOLETE because redundant and identical to MOD:00686. Remap to MOD:00686." [PubMed:12148805, UniMod:162] synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label [] synonym: "Selenium replaces sulphur" RELATED UniMod-description [] xref: DiffAvg: "46.91" xref: DiffFormula: "S -1 Se 1" xref: DiffMono: "47.944450" xref: Formula: "C 3 H 5 N 1 O 1 S 0 Se 1" xref: MassAvg: "150.05" xref: MassMono: "150.953635" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01344 name: dehydrogenated residue - site S def: "OBSOLETE because redundant and identical with MOD:00835. Remap to MOD:00835." [PubMed:9252331, PubMed:9276974, UniMod:401] synonym: "2-amino-3-oxo-butanoic_acid" RELATED UniMod-description [] synonym: "Didehydro" RELATED PSI-MS-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "H -2" xref: DiffMono: "-2.015650" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01345 name: 2-amino-3-oxobutanoic acid def: "A protein modification that effectively converts an L-threonine residue to 2-amino-3-oxobutanoic acid." [OMSSA:23, PubMed:12716131, PubMed:9252331, UniMod:401#T] comment: There is no citation for this modification in the UniMod entry. Although mentioned in PubMed:9252331, there is no citation for it there [JSG]. synonym: "2-amino-3-ketobutyric acid" EXACT PSI-MOD-alternate [] synonym: "2-amino-3-oxo-butanoic_acid" RELATED UniMod-description [] synonym: "3-ketobutyrine" EXACT PSI-MOD-alternate [] synonym: "Didehydro" RELATED PSI-MS-label [] synonym: "twoamino3oxobutanoicacid" EXACT OMSSA-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "H -2" xref: DiffMono: "-2.015650" xref: Formula: "C 4 H 5 N 1 O 2" xref: MassAvg: "99.09" xref: MassMono: "99.032028" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01346 name: N4-hexosylated asparagine def: "A protein modification that effectively converts an L-asparagine residue to an N4-hexosyl-L-asparagine." [PubMed:11112526, PubMed:11567090, PubMed:15279557, PubMed:6540775, UniMod:41#N] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 10 H 16 N 2 O 7" xref: MassAvg: "276.25" xref: MassMono: "276.095751" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00160 ! N4-glycosyl-L-asparagine is_a: MOD:00434 ! hexosylated residue [Term] id: MOD:01347 name: hexose glycated L-lysine def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and an L-lysine residue to form a Schiff-base or an Amadori ketosamine lysine adduct." [DeltaMass:0, PubMed:15279557, UniMod:41#K] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 12 H 22 N 2 O 6" xref: MassAvg: "290.32" xref: MassMono: "290.147786" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00767 ! glycated residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01348 name: O-hexosylated threonine def: "A protein modification that effectively converts an L-threonine residue to an O-hexosyl-L-threonine." [PubMed:15279557, PubMed:8597590, UniMod:41#T] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] xref: DiffAvg: "162.14" xref: DiffFormula: "C 6 H 10 O 5" xref: DiffMono: "162.052823" xref: Formula: "C 10 H 17 N 1 O 7" xref: MassAvg: "263.25" xref: MassMono: "263.100502" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00005 ! O-glycosyl-L-threonine is_a: MOD:00434 ! hexosylated residue [Term] id: MOD:01349 name: hydrolyzed N-ethylmaleimide cysteine adduct def: "modification from UniMod Chemical derivative -" [UniMod:320#C] comment: Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(S-cysteinyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. synonym: "Nethylmaleimide+water" RELATED PSI-MS-label [] synonym: "Nethylmaleimidehydrolysis" RELATED UniMod-description [] xref: DiffAvg: "143.14" xref: DiffFormula: "C 6 H 9 N 1 O 3" xref: DiffMono: "143.058243" xref: Formula: "C 9 H 14 N 2 O 4 S 1" xref: MassAvg: "246.28" xref: MassMono: "246.067428" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00631 ! hydrolyzed N-ethylmaleimide adduct is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01350 name: hydrolyzed N-ethylmaleimide lysine adduct def: "modification from UniMod Chemical derivative -" [UniMod:320#K] comment: Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(N6-lysyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. synonym: "Nethylmaleimide+water" RELATED PSI-MS-label [] synonym: "Nethylmaleimidehydrolysis" RELATED UniMod-description [] xref: DiffAvg: "143.14" xref: DiffFormula: "C 6 H 9 N 1 O 3" xref: DiffMono: "143.058243" xref: Formula: "C 12 H 21 N 3 O 4" xref: MassAvg: "271.32" xref: MassMono: "271.153206" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00631 ! hydrolyzed N-ethylmaleimide adduct [Term] id: MOD:01351 name: nitrated L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to a nitrated L-tryptophan." [OMSSA:85, PubMed:8839040, PubMed:9252331, UniMod:354#W] comment: One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. synonym: "Nitro" RELATED PSI-MS-label [] synonym: "nitrow" EXACT OMSSA-label [] synonym: "Oxidation to nitro" RELATED UniMod-description [] xref: DiffAvg: "45.00" xref: DiffFormula: "H -1 N 1 O 2" xref: DiffMono: "44.985078" xref: Formula: "C 11 H 9 N 3 O 3" xref: MassAvg: "231.21" xref: MassMono: "231.064391" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00461 ! nitrosylation is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01352 name: nitrated L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to a nitrated L-tyrosine." [OMSSA:86, PubMed:14678012, PubMed:8839040, PubMed:9252331, UniMod:354#Y] comment: One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. subset: PSI-MOD-slim synonym: "Nitro" RELATED PSI-MS-label [] synonym: "nitroy" EXACT OMSSA-label [] synonym: "Oxidation to nitro" RELATED UniMod-description [] xref: DiffAvg: "45.00" xref: DiffFormula: "H -1 N 1 O 2" xref: DiffMono: "44.985078" xref: Formula: "C 9 H 8 N 2 O 4" xref: MassAvg: "208.17" xref: MassMono: "208.048407" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00461 ! nitrosylation is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01353 name: amidination of lysines or N-terminal amines with methyl acetimidate - site K def: "modification from UniMod Chemical derivative -" [PubMed:12643539, PubMed:15602776, PubMed:6273432, UniMod:141#K] synonym: "amidination of lysines or N-terminal amines with methyl acetimidate" RELATED UniMod-description [] synonym: "Amidine" RELATED PSI-MS-label [] xref: DiffAvg: "41.05" xref: DiffFormula: "C 2 H 3 N 1" xref: DiffMono: "41.026549" xref: Formula: "C 8 H 15 N 3 O 1" xref: MassAvg: "169.23" xref: MassMono: "169.121512" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00509 ! amidination of lysines or N-terminal amines with methyl acetimidate is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01354 name: Hex1HexNAc1NeuAc1 N4-glycosylated asparagine def: "A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [PubMed:11698400, UniMod:149#N] synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1NeuAc1" RELATED UniMod-description [] xref: DiffAvg: "657.60" xref: DiffFormula: "C 25 H 41 N 2 O 18" xref: DiffMono: "657.235437" xref: Formula: "C 29 H 47 N 4 O 20" xref: MassAvg: "771.70" xref: MassMono: "771.278365" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:01355 name: Hex1HexNAc1NeuAc1O-glycosylated threonine def: "A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [UniMod:149#T] synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1NeuAc1" RELATED UniMod-description [] xref: DiffAvg: "657.60" xref: DiffFormula: "C 25 H 41 N 2 O 18" xref: DiffMono: "657.235437" xref: Formula: "C 29 H 48 N 3 O 20" xref: MassAvg: "758.70" xref: MassMono: "758.283116" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01356 name: Hex1HexNAc1NeuAc1 O-glycosylated serine def: "A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [PubMed:7856876, UniMod:149#S] synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label [] synonym: "Hex1HexNAc1NeuAc1" RELATED UniMod-description [] xref: DiffAvg: "657.60" xref: DiffFormula: "C 25 H 41 N 2 O 18" xref: DiffMono: "657.235437" xref: Formula: "C 28 H 46 N 3 O 20" xref: MassAvg: "744.68" xref: MassMono: "744.267466" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01357 name: 2x(13)C,4x(2)H labeled dimethylated L-lysine def: "A protein modification that effectively replaces two hydrogen atoms of an L-lysine residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-lysine." [PubMed:12686488, PubMed:16335955, UniMod:510#K] synonym: "DiMethyl-C13HD2" RELATED UniMod-description [] synonym: "Dimethyl:2H(4)13C(2)" RELATED PSI-MS-label [] xref: DiffAvg: "34.06" xref: DiffFormula: "(13)C 2 (2)H 4" xref: DiffMono: "34.063117" xref: Formula: "(12)C 6 (13)C 2 (1)H 12 (2)H 4 N 2 O 1" xref: MassAvg: "162.16" xref: MassMono: "162.158080" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:00927 ! 2x(13)C,4x(2)H labeled dimethylated residue relationship: derives_from MOD:00084 ! N6,N6-dimethyl-L-lysine [Term] id: MOD:01358 name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site N-term def: "modification from UniMod Isotopic label - Use when labelling post-digest" [PubMed:15602776, UniMod:687#N-term] synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form" RELATED UniMod-description [] synonym: "ICPL:2H(4)" RELATED PSI-MS-label [] xref: DiffAvg: "109.05" xref: DiffFormula: "C 6 (1)H -1 (2)H 4 N 1 O 1" xref: DiffMono: "109.046571" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01359 name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site K def: "modification from UniMod Isotopic label - Use when labelling post-digest" [PubMed:15602776, UniMod:687#K] synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form" RELATED UniMod-description [] synonym: "ICPL:2H(4)" RELATED PSI-MS-label [] xref: DiffAvg: "109.05" xref: DiffFormula: "C 6 (1)H -1 (2)H 4 N 1 O 1" xref: DiffMono: "109.046571" xref: Formula: "C 12 (1)H 11 (2)H 4 N 3 O 2" xref: MassAvg: "237.14" xref: MassMono: "237.141534" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01360 name: 4-sulfophenyl isothiocyanate N6-derivatized lysine def: "A protein modification that effectively converts an L-lysine residue to the 4-sulfophenyl isothiocyanate adduct, N6-[(4-sulfophenyl)carbamothioyl]lysine." [PubMed:14689565, PubMed:14745769, PubMed:15549660, PubMed:16526082, UniMod:261#K] synonym: "4-sulfophenyl isothiocyanate" RELATED UniMod-description [] synonym: "N6-[(4-sulfophenyl)carbamothioyl]lysine" EXACT PSI-MOD-alternate [] synonym: "SPITC" RELATED PSI-MS-label [] xref: DiffAvg: "215.24" xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2" xref: DiffMono: "214.971085" xref: Formula: "C 13 H 17 N 3 O 4 S 2" xref: MassAvg: "343.42" xref: MassMono: "343.066048" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01361 name: O-thiophospho-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-thiophospho-L-threonine." [PubMed:11507762, PubMed:12110917, UniMod:260#T] synonym: "Thiophospho" RELATED PSI-MS-label [] synonym: "Thiophosphorylation" RELATED UniMod-description [] xref: DiffAvg: "96.04" xref: DiffFormula: "H 1 O 2 P 1 S 1" xref: DiffMono: "95.943487" xref: Formula: "C 4 H 8 N 1 O 4 P 1 S 1" xref: MassAvg: "197.14" xref: MassMono: "196.991165" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00583 ! thiophosphorylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01362 name: O-thiophospho-L-serine def: "A protein modification that effectively converts an L-serine residue to O-thiophospho-L-serine." [PubMed:11507762, PubMed:12110917, UniMod:260#S] synonym: "Thiophospho" RELATED PSI-MS-label [] synonym: "Thiophosphorylation" RELATED UniMod-description [] xref: DiffAvg: "96.04" xref: DiffFormula: "H 1 O 2 P 1 S 1" xref: DiffMono: "95.943487" xref: Formula: "C 3 H 6 N 1 O 4 P 1 S 1" xref: MassAvg: "183.12" xref: MassMono: "182.975515" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00583 ! thiophosphorylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01363 name: O4'-thiophospho-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to O4'-thiophospho-L-tyrosine." [PubMed:12110917, PubMed:15549660, UniMod:260#Y] synonym: "Thiophospho" RELATED PSI-MS-label [] synonym: "Thiophosphorylation" RELATED UniMod-description [] xref: DiffAvg: "96.04" xref: DiffFormula: "H 1 O 2 P 1 S 1" xref: DiffMono: "95.943487" xref: Formula: "C 9 H 10 N 1 O 4 P 1 S 1" xref: MassAvg: "259.22" xref: MassMono: "259.006815" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00583 ! thiophosphorylated residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01364 name: fluorescein-5-thiosemicarbazide - site S def: "modification from UniMod Chemical derivative -" [PubMed:11467524, UniMod:478#S] synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] synonym: "FTC" RELATED PSI-MS-label [] xref: DiffAvg: "421.43" xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" xref: DiffMono: "421.073242" xref: Formula: "C 24 H 20 N 4 O 7 S 1" xref: MassAvg: "508.51" xref: MassMono: "508.105270" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01365 name: fluorescein-5-thiosemicarbazide - site C def: "modification from UniMod Chemical derivative -" [UniMod:478#C] synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] synonym: "FTC" RELATED PSI-MS-label [] xref: DiffAvg: "421.43" xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" xref: DiffMono: "421.073242" xref: Formula: "C 24 H 20 N 4 O 6 S 2" xref: MassAvg: "524.57" xref: MassMono: "524.082426" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01366 name: fluorescein-5-thiosemicarbazide - site K def: "modification from UniMod Chemical derivative -" [UniMod:478#K] synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] synonym: "FTC" RELATED PSI-MS-label [] xref: DiffAvg: "421.43" xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" xref: DiffMono: "421.073242" xref: Formula: "C 27 H 27 N 5 O 6 S 1" xref: MassAvg: "549.60" xref: MassMono: "549.168205" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01367 name: fluorescein-5-thiosemicarbazide - site P def: "modification from UniMod Chemical derivative -" [UniMod:478#P] synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] synonym: "FTC" RELATED PSI-MS-label [] xref: DiffAvg: "421.43" xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" xref: DiffMono: "421.073242" xref: Formula: "C 26 H 22 N 4 O 6 S 1" xref: MassAvg: "518.54" xref: MassMono: "518.126005" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:01368 name: fluorescein-5-thiosemicarbazide - site R def: "modification from UniMod Chemical derivative -" [PubMed:15525938, UniMod:478#R] synonym: "fluorescein-5-thiosemicarbazide" RELATED UniMod-description [] synonym: "FTC" RELATED PSI-MS-label [] xref: DiffAvg: "421.43" xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1" xref: DiffMono: "421.073242" xref: Formula: "C 27 H 27 N 7 O 6 S 1" xref: MassAvg: "577.62" xref: MassMono: "577.174353" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:01369 name: deamidated and methyl esterified residue def: "A protein modification that effectively replaces a carboxamido group with a carboxyl methyl ester group." [UniMod:528] subset: PSI-MOD-slim synonym: "Deamidation followed by a methylation" RELATED UniMod-description [] synonym: "Methyl+Deamidated" RELATED PSI-MS-label [] xref: DiffAvg: "15.01" xref: DiffFormula: "C 1 H 1 N -1 O 1" xref: DiffMono: "14.999666" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00393 ! O-methylated residue is_a: MOD:00400 ! deamidated residue [Term] id: MOD:01370 name: 6x(13)C,1x(15)N labeled residue def: "A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C,1x(15)N labeled residue." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:695] synonym: "13C(6) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "7.02" xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1" xref: DiffMono: "7.017164" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00842 ! (13)C labeled residue is_a: MOD:00843 ! (15)N labeled residue [Term] id: MOD:01371 name: deamidation in presence of O18 def: "OBSOLETE bcecause identical and redundant with MOD:00851. Remap to MOD:00851." [PubMed:8382902] synonym: "Deamidated:18O(1)" RELATED PSI-MS-label [] synonym: "Deamidation in presence of O18" RELATED UniMod-description [] xref: DiffAvg: "2.99" xref: DiffFormula: "H -1 N -1 (18)O 1" xref: DiffMono: "2.988262" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01372 name: (2S)-4-hydroxyleucine def: "A protein modification that effectively converts an L-leucine residue to a (2S)-4-hydroxyleucine." [PubMed:363352, PubMed:9164839, RESID:AA0442] synonym: "(2S)-2-amino-4-hydroxy-4-methylpentanoic acid" EXACT RESID-systematic [] synonym: "(2S)-4-hydroxyleucine" EXACT RESID-name [] synonym: "gamma-hydroxyleucine" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 11 N 1 O 2" xref: MassAvg: "129.16" xref: MassMono: "129.078979" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01411 ! monohydroxylated leucine [Term] id: MOD:01373 name: (2S,4R)-5-hydroxyleucine def: "A protein modification that effectively converts an L-leucine residue to a (2S,4R)-5-hydroxyleucine." [PubMed:16858410, PubMed:7690768, PubMed:9164839, RESID:AA0443] synonym: "(2S,4R)-2-amino-5-hydroxy-4-methylpentanoic acid" EXACT RESID-systematic [] synonym: "(2S,4R)-5-hydroxyleucine" EXACT RESID-name [] synonym: "(4R)-5-hydroxyleucine" EXACT RESID-alternate [] synonym: "delta-hydroxyleucine" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 11 N 1 O 2" xref: MassAvg: "129.16" xref: MassMono: "129.078979" xref: Origin: "L" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01411 ! monohydroxylated leucine [Term] id: MOD:01374 name: (2S,4R)-5-oxoleucine def: "A modification that effectively oxygenates C5 of an L-leucine residue to form a (2S,4R)-5-oxoleucine." [ChEBI:43739, PubMed:16858410, RESID:AA0444] synonym: "(2S,4R)-2-amino-4-methyl-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(2S,4R)-5-oxoleucine" EXACT RESID-name [] synonym: "(4R)-5-oxo-L-leucine" EXACT RESID-alternate [] xref: DiffAvg: "13.98" xref: DiffFormula: "C 0 H -2 N 0 O 1" xref: DiffMono: "13.979265" xref: Formula: "C 6 H 9 N 1 O 2" xref: MassAvg: "127.14" xref: MassMono: "127.063329" xref: Origin: "L" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00911 ! modified L-leucine residue [Term] id: MOD:01375 name: (2S,4R)-4,5-dihydroxyleucine def: "A protein modification that effectively converts an L-leucine residue to a (2S,4R)-4,5-dihydroxyleucine." [PubMed:6010785, PubMed:6893271, RESID:AA0445] synonym: "(2S,4R)-2-amino-4,5-dihydroxy-4-methylpentanoic acid" EXACT RESID-systematic [] synonym: "(2S,4R)-4,5-dihydroxyleucine" EXACT RESID-name [] synonym: "(4R)-4,5-dihydroxyleucine" EXACT RESID-alternate [] synonym: "gamma,delta-dihydroxyleucine" EXACT RESID-alternate [] synonym: "MOD_RES (4R)-4,5-dihydroxyleucine" EXACT UniProt-feature [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 6 H 11 N 1 O 3" xref: MassAvg: "145.16" xref: MassMono: "145.073893" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01412 ! dihydroxylated leucine [Term] id: MOD:01376 name: (2S,3S,4R)-3,4-dihydroxyisoleucine def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3S,4R)-3,4-dihydroxyisoleucine." [PubMed:11320328, RESID:AA0447] synonym: "(2S,3S,4R)-2-amino-3,4-dihydroxy-3-methylpentanoic acid" EXACT RESID-systematic [] synonym: "(2S,3S,4R)-3,4-dihydroxyisoleucine" EXACT RESID-name [] synonym: "(3S,4R)-3,4-dihydroxyisoleucine" EXACT RESID-alternate [] synonym: "beta,gamma-dihydroxyisoleucine" EXACT RESID-alternate [] synonym: "MOD_RES (3S,4R)-3,4-dihydroxyisoleucine" EXACT UniProt-feature [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 6 H 11 N 1 O 3" xref: MassAvg: "145.16" xref: MassMono: "145.073893" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01416 ! dihydroxylated isoleucine [Term] id: MOD:01377 name: (2S,3R,4S)-4-hydroxyisoleucine def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4S)-4-hydroxyisoleucine." [PubMed:363352, RESID:AA0448] synonym: "(2S,3R,4S)-2-amino-3-methyl-4-hydroxyvaleric acid" EXACT RESID-alternate [] synonym: "(2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R,4S)-4-hydroxyisoleucine" EXACT RESID-name [] synonym: "(3R,4S)-4-hydroxyisoleucine" EXACT RESID-alternate [] synonym: "gamma-hydroxyisoleucine" EXACT RESID-alternate [] synonym: "MOD_RES (3R,4S)-4-hydroxyisoleucine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 11 N 1 O 2" xref: MassAvg: "129.16" xref: MassMono: "129.078979" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01415 ! monohydroxylated isoleucine [Term] id: MOD:01378 name: (2S,3R,4R)-4,5-dihydroxyisoleucine def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4R)-4,5-dihydroxyisoleucine." [PubMed:11805306, PubMed:18552824, PubMed:363352, RESID:AA0449] synonym: "(2S,3R,4R)-2-amino-4,5-dihydroxy-3-methylpentanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R,4R)-4,5-dihydroxyisoleucine" EXACT RESID-name [] synonym: "(3R,4R)-4,5-dihydroxyisoleucine" EXACT RESID-alternate [] synonym: "gamma,delta-dihydroxyisoleucine" EXACT RESID-alternate [] synonym: "MOD_RES (3R,4R)-4,5-dihydroxyisoleucine" EXACT UniProt-feature [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 6 H 11 N 1 O 3" xref: MassAvg: "145.16" xref: MassMono: "145.073893" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01416 ! dihydroxylated isoleucine [Term] id: MOD:01379 name: 2'-methylsulfonyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 2'-methylsulfonyl-L-tryptophan." [PubMed:6893271, RESID:AA0450] synonym: "2'-methylsulfonyl-L-tryptophan" EXACT RESID-name [] synonym: "2-methylsulfonyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole" EXACT RESID-systematic [] synonym: "MOD_RES 2'-methylsulfonyltryptophan" EXACT UniProt-feature [] xref: DiffAvg: "78.09" xref: DiffFormula: "C 1 H 2 N 0 O 2 S 1" xref: DiffMono: "77.977550" xref: Formula: "C 12 H 12 N 2 O 3 S 1" xref: MassAvg: "264.30" xref: MassMono: "264.056863" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01380 name: 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide." [PubMed:11805306, PubMed:18552824, PubMed:363352, PubMed:4865716, RESID:AA0451] comment: Cross-link 2. synonym: "2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide" EXACT RESID-name [] synonym: "2-((2R)-2-amino-2carboxyethyl)sulfinyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole" EXACT RESID-systematic [] synonym: "6'-hydroxy-S-oxo-tryptathionine" EXACT RESID-alternate [] synonym: "CROSSLNK 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys)" EXACT UniProt-feature [] xref: DiffAvg: "29.98" xref: DiffFormula: "C 0 H -2 N 0 O 2 S 0" xref: DiffMono: "29.974179" xref: Formula: "C 14 H 13 N 3 O 4 S 1" xref: MassAvg: "319.33" xref: MassMono: "319.062677" xref: Origin: "C, W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00687 ! thioether crosslinked residues is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01381 name: O-palmitoleyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine." [OMSSA:186, PubMed:17141155, RESID:AA0455] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-((9Z)-9-hexadecenoyloxy)propanoic acid" EXACT RESID-systematic [] synonym: "L-serine cis-9-hexadecenoate ester" EXACT RESID-alternate [] synonym: "LIPID O-palmitoleyl serine" EXACT UniProt-feature [] synonym: "mod186" EXACT OMSSA-label [] synonym: "O-palmitoleyl-L-serine" EXACT RESID-name [] synonym: "O3-palmitoleyl-serine" EXACT RESID-alternate [] xref: DiffAvg: "236.40" xref: DiffFormula: "C 16 H 28 N 0 O 1" xref: DiffMono: "236.214016" xref: Formula: "C 19 H 33 N 1 O 3" xref: MassAvg: "323.48" xref: MassMono: "323.246044" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01768 ! O-palmitoleylated residue [Term] id: MOD:01382 name: N,N,N-trimethyl-L-methionine def: "A protein modification that effectively converts an L-methionine residue to N,N,N-trimethyl-L-methionine." [PubMed:18611379, RESID:AA0456] subset: PSI-MOD-slim synonym: "(1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanaminium" EXACT RESID-systematic [] synonym: "(1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanazanium" EXACT RESID-alternate [] synonym: "2-trimethylammonio-4-(methylthio)butanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N,N,N-trimethylmethionine" EXACT UniProt-feature [] synonym: "N,N,N-trimethyl-L-methionine" EXACT RESID-name [] synonym: "N,N,N-trimethylmethionine cation" EXACT RESID-alternate [] synonym: "N,N,N-trimethylmethioninium" EXACT RESID-alternate [] synonym: "N2Me3+Met" EXACT PSI-MOD-label [] xref: DiffAvg: "43.09" xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0" xref: DiffMono: "43.054227" xref: FormalCharge: "1+" xref: Formula: "C 8 H 17 N 1 O 1 S 1" xref: MassAvg: "175.29" xref: MassMono: "175.102537" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01463 ! N-methylated methionine is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue [Term] id: MOD:01383 name: L-cystine S-oxide def: "A protein modification that effectively cross-links two L-cysteine residues and oxidizes a sulfur to form L-cystine S-oxide." [RESID:AA0457] comment: Cross-link 2. synonym: "(2R)-2-amino-3-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)sulfinyl]propanoic acid" EXACT RESID-systematic [] synonym: "CROSSLNK S-cysteinyl 3-(oxidosulfanyl)alanine (Cys-Cys)" EXACT UniProt-feature [] synonym: "cystine sulfoxide" EXACT RESID-alternate [] synonym: "L-cystine S-oxide" EXACT RESID-name [] synonym: "S-[(2R)-2-amino-3-oxopropyl] (2R)-2-amino-3-oxopropane-1-sulfinothioate" EXACT RESID-alternate [] synonym: "S-cysteinyl 3-(oxidosulfanyl)alanine" EXACT RESID-alternate [] xref: DiffAvg: "13.98" xref: DiffFormula: "C 0 H -2 N 0 O 1 S 0" xref: DiffMono: "13.979265" xref: Formula: "C 6 H 8 N 2 O 3 S 2" xref: MassAvg: "220.26" xref: MassMono: "219.997634" xref: Origin: "C, C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00689 ! disulfide crosslinked residues [Term] id: MOD:01384 name: aminomalonic acid (Ser) def: "A protein modification that effectively converts an L-serine residue to an aminomalonic acid." [PubMed:1621954, PubMed:5415959, PubMed:6366787, PubMed:7457858, RESID:AA0458] synonym: "2-carboxyglycine" EXACT RESID-alternate [] synonym: "Ama" EXACT RESID-alternate [] synonym: "aminomalonic acid" EXACT RESID-name [] synonym: "aminopropanedioic acid" EXACT RESID-systematic [] synonym: "MOD_RES Aminomalonic acid (Ser)" EXACT UniProt-feature [] xref: DiffAvg: "13.98" xref: DiffFormula: "C 0 H -2 N 0 O 1 S 0" xref: DiffMono: "13.979265" xref: Formula: "C 3 H 3 N 1 O 3" xref: MassAvg: "101.06" xref: MassMono: "101.011293" xref: Origin: "S" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01385 name: 3-hydroxy-L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to 3-hydroxy-L-phenylalanine." [ChEBI:16795, OMSSA:63, PubMed:10625477, PubMed:15651011, PubMed:16734421, PubMed:1880060, PubMed:7398618, PubMed:7844053, RESID:AA0462] synonym: "(2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid" EXACT RESID-systematic [] synonym: "3-hydoxyphenylalanine" EXACT RESID-alternate [] synonym: "3-hydroxy-L-phenylalanine" EXACT RESID-name [] synonym: "3-phenyl-L-serine" EXACT RESID-alternate [] synonym: "3HyPhe" EXACT PSI-MOD-label [] synonym: "beta-hydroxyphenylalanine" EXACT RESID-alternate [] synonym: "beta-phenylserine" EXACT RESID-alternate [] synonym: "hydroxylationf" EXACT OMSSA-label [] synonym: "L-threo-3-phenylserine" EXACT RESID-alternate [] synonym: "MOD_RES 3-hydroxyphenylalanine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 9 H 9 N 1 O 2" xref: MassAvg: "163.18" xref: MassMono: "163.063329" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue is_a: MOD:00914 ! modified L-phenylalanine residue [Term] id: MOD:01386 name: 3-hydroxy-L-valine def: "A protein modification that effectively converts an L-valine residue to 3-hydroxy-L-valine." [PubMed:7328054, RESID:AA0463] synonym: "(2S)-2-amino-3-hydroxy-3-methylbutanoic acid" EXACT RESID-systematic [] synonym: "3-hydroxy-L-valine" EXACT RESID-name [] synonym: "3-hydroxyvaline" EXACT RESID-alternate [] synonym: "3HyVal" EXACT PSI-MOD-label [] synonym: "MOD_RES 3-hydroxyvaline" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 9 N 1 O 2" xref: MassAvg: "115.13" xref: MassMono: "115.063329" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue is_a: MOD:00920 ! modified L-valine residue [Term] id: MOD:01387 name: O-methyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-methyl-L-threonine." [PubMed:7328054, RESID:AA0464] synonym: "(2S,3R)-2-amino-3-methoxybutanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES O-methylthreonine" EXACT UniProt-feature [] synonym: "O-methyl threonine" EXACT RESID-alternate [] synonym: "O-methyl-L-threonine" EXACT RESID-name [] synonym: "OMeThr" EXACT PSI-MOD-label [] synonym: "threonine methyl ether" EXACT RESID-alternate [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 5 H 9 N 1 O 2" xref: MassAvg: "115.13" xref: MassMono: "115.063329" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01803 ! O-methylated threonine [Term] id: MOD:01388 name: 1-amino-2-propanol def: "A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanol." [ChEBI:15675, PubMed:7328054, RESID:AA0465] synonym: "(2R)-1-aminopropan-2-ol" EXACT RESID-systematic [] synonym: "1-amino-2-hydroxypropane" EXACT RESID-alternate [] synonym: "1-amino-2-propanol" EXACT RESID-name [] synonym: "1-methyl-2-aminoethanol" EXACT RESID-alternate [] synonym: "2-amino-1-methylethanol" EXACT RESID-alternate [] synonym: "2-hydroxy-1-propylamine" EXACT RESID-alternate [] synonym: "2-hydroxypropanamine" EXACT RESID-alternate [] synonym: "2-hydroxypropylamine" EXACT RESID-alternate [] synonym: "alpha-aminoisopropyl alcohol" EXACT RESID-alternate [] synonym: "dCbxThr" EXACT PSI-MOD-label [] synonym: "decarboxylated threonine" EXACT RESID-alternate [] synonym: "isopropanolamine" EXACT RESID-alternate [] synonym: "MOD_RES Decarboxylated threonine" EXACT UniProt-feature [] synonym: "threamine" EXACT RESID-alternate [] xref: DiffAvg: "-44.01" xref: DiffFormula: "C -1 H 0 N 0 O -2" xref: DiffMono: "-43.989829" xref: Formula: "C 3 H 8 N 1 O 1" xref: MassAvg: "74.10" xref: MassMono: "74.060589" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:00960 ! decarboxylated residue [Term] id: MOD:01389 name: L-isoleucine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-isoleucine residue to form L-isoleucine thiazole-4-carboxylic acid." [PubMed:11320328, RESID:AA0466] comment: Cross-link 2. synonym: "2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-zanyl-2-methylbutyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Ile-Cys)" EXACT UniProt-feature [] synonym: "L-isoleucine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 9 H 12 N 2 O 1 S 1" xref: MassAvg: "196.27" xref: MassMono: "196.067034" xref: Origin: "C, I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00910 ! modified L-isoleucine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01390 name: L-valine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue to form L-valine thiazole-4-carboxylic acid." [PubMed:7328054, RESID:AA0467] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-2-methylpropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-methylpropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Val-Cys)" EXACT UniProt-feature [] synonym: "L-valine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 8 H 10 N 2 O 1 S 1" xref: MassAvg: "182.24" xref: MassMono: "182.051384" xref: Origin: "C, V" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00920 ! modified L-valine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01391 name: L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue, and C-5 methoxymethylates to form L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0468] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK 5-(methoxymethyl)thiazole-4-carboxylic acid (Val-Cys)" EXACT UniProt-feature [] synonym: "L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "24.02" xref: DiffFormula: "C 2 H 0 N 0 O 0 S 0" xref: DiffMono: "24.000000" xref: Formula: "C 10 H 14 N 2 O 2 S 1" xref: MassAvg: "226.29" xref: MassMono: "226.077599" xref: Origin: "C, V" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00920 ! modified L-valine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01392 name: L-asparagine 5-methylthiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue, and C-4 methylates to form L-asparagine 5-methylthiazole-4-carboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0469] comment: Cross-link 2. synonym: "2-[(1S)-1,3-bisazanyl-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "2-[(1S)-1,3-diamino-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "CROSSLNK 5-methylthiazole-4-carboxylic acid (Asn-Cys)" EXACT UniProt-feature [] synonym: "L-asparagine 5-methylthiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-6.00" xref: DiffFormula: "C 1 H -2 N 0 O -1 S 0" xref: DiffMono: "-6.010565" xref: Formula: "C 8 H 9 N 3 O 2 S 1" xref: MassAvg: "211.24" xref: MassMono: "211.041548" xref: Origin: "C, N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue relationship: derives_from MOD:00656 ! C-methylated residue [Term] id: MOD:01393 name: L-cysteine pyridine-2,5-dicarboxylic acid def: "A protein modification that crosslinks two serine residues and a cysteine residue by formation of a pyridine-2,5-dicarboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0470] comment: Cross-link 3. synonym: "6-[(1R)-1-amino-2-sulfanylethyl]pyridine-2,5-dicarboxylic acid" EXACT RESID-systematic [] synonym: "L-cysteine pyridine-2,5-dicarboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-70.07" xref: DiffFormula: "C 0 H -8 N -1 O -3 S 0" xref: DiffMono: "-70.050418" xref: Formula: "C 9 H 7 N 2 O 2 S 1" xref: MassAvg: "207.23" xref: MassMono: "207.022823" xref: Origin: "C, S, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01425 ! pyridinyl ring crosslinked residues [Term] id: MOD:01394 name: L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid def: "A protein modification that crosslinks two serine residues and a cysteine residue by formation of a 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid." [PubMed:11320328, RESID:AA0471] comment: Cross-link 3. synonym: "(5R,6R)-5-amino-6-[(1R)-1-amino-2-sulfanylethyl]-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid" EXACT RESID-systematic [] synonym: "L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid" EXACT RESID-name [] synonym: "L-cysteine 5-aminopiperideine-2,5-dicarboxylic acid" EXACT RESID-alternate [] xref: DiffAvg: "-53.04" xref: DiffFormula: "C 0 H -5 N 0 O -3 S 0" xref: DiffMono: "-53.023869" xref: Formula: "C 9 H 11 N 3 O 2 S 1" xref: MassAvg: "225.27" xref: MassMono: "225.057198" xref: Origin: "C, S, S" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01425 ! pyridinyl ring crosslinked residues [Term] id: MOD:01395 name: 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol def: "A protein modification that effectively results from forming an adduct between an isoleucine residue, a threonine residue and the quinaldate compound 2-carboxy-4-(1-hydroxyethyl)--7,8-dihydroquinolin-8-ol." [PubMed:11320328, RESID:AA0472] comment: Cross-link 2. synonym: "(7R,8S)-7-[(1S,2S)-1-carboxy-2-methylbutyl]amino-2-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)carbonyl-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7,8-dihydroquinoline" EXACT RESID-systematic [] synonym: "4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol" EXACT RESID-name [] synonym: "BINDING 4-(1-hydroxyethyl)-7,8-dihydroquinolin-8-ol (covalent; via 2 links)" EXACT UniProt-feature [] xref: DiffAvg: "215.21" xref: DiffFormula: "C 12 H 9 N 1 O 3" xref: DiffMono: "215.058243" xref: Formula: "C 22 H 28 N 3 O 6" xref: MassAvg: "430.48" xref: MassMono: "430.197811" xref: Origin: "I, T" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00910 ! modified L-isoleucine residue is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01424 ! quinaldate modified residue [Term] id: MOD:01396 name: 5-hydroxy-3-methyl-L-proline (Pro) def: "A protein modification that effectively converts an L-proline residue to a 5-hydroxy-3-methyl-L-proline." [PubMed:7592021, PubMed:8557573, RESID:AA0473] comment: This entry is for the hypothetical formation of 5-hydroxy-3-methyl-L-proline from proline. For the natural production from L-isoleucine, use MOD:01897 [JSG]. synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name [] synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate [] synonym: "5Hy3MePro" EXACT PSI-MOD-label [] synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate [] synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature [] xref: DiffAvg: "30.03" xref: DiffFormula: "C 1 H 2 N 0 O 1" xref: DiffMono: "30.010565" xref: Formula: "C 6 H 9 N 1 O 2" xref: MassAvg: "127.14" xref: MassMono: "127.063329" xref: Origin: "P" xref: Source: "artifactual" xref: TermSpec: "none" is_a: MOD:00915 ! modified L-proline residue relationship: has_functional_parent MOD:01024 ! monohydroxylated proline relationship: has_functional_parent MOD:01417 ! monomethylated proline [Term] id: MOD:01397 name: L-serine 5-methyloxazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0474] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Ser-Thr)" EXACT UniProt-feature [] synonym: "L-serine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1" xref: DiffMono: "-20.026215" xref: Formula: "C 7 H 8 N 2 O 3" xref: MassAvg: "168.15" xref: MassMono: "168.053492" xref: Origin: "S, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr) is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01398 name: N6-propanoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-propanoyl-L-lysine." [PubMed:17267393, PubMed:17684016, PubMed:20715035, RESID:AA0475, UniMod:58#K] comment: The binding of histone peptides with propanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(propanoylamino)hexanoic acid" EXACT RESID-systematic [] synonym: "2-amino-6-propionylaminocaproic acid" EXACT RESID-alternate [] synonym: "epsilon-propanoyl-L-lysine" EXACT RESID-alternate [] synonym: "epsilon-propionyl-L-lysine" EXACT RESID-alternate [] synonym: "N(zeta)-propanoyllysine" EXACT RESID-alternate [] synonym: "N6-(1-oxopropyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-propanoyl-L-lysine" EXACT RESID-name [] synonym: "N6-propionyllysine" EXACT RESID-alternate [] xref: DiffAvg: "56.06" xref: DiffFormula: "C 3 H 4 N 0 O 1" xref: DiffMono: "56.026215" xref: Formula: "C 9 H 16 N 2 O 2" xref: MassAvg: "184.24" xref: MassMono: "184.121178" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01155 ! lipoconjugated residue is_a: MOD:01875 ! N6-acylated L-lysine is_a: MOD:01894 ! propanoylated residue [Term] id: MOD:01399 name: N6-(ADP-ribosyl)-L-lysine def: "A protein modification that effectively converts an L-lysine residue to an N6-(ADP-ribosyl)-L-lysine." [PubMed:18436469, RESID:AA0476] synonym: "(S)-2-amino-6-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "2-amino-6-(ADP-ribosyl)amino-hexanoic acid" EXACT RESID-alternate [] synonym: "epsilon-ADP-ribosyllysine" EXACT RESID-alternate [] synonym: "MOD_RES N6-(ADP-ribosyl)lysine" EXACT UniProt-feature [] synonym: "N(zeta)-ADP-ribosyllysine" EXACT RESID-alternate [] synonym: "N6-(ADP-ribosyl)-L-lysine" EXACT RESID-name [] synonym: "N6-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-lysine" EXACT RESID-alternate [] synonym: "N6-alpha-D-ribofuranosyl-L-lysine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "C 21 H 33 N 7 O 14 P 2" xref: MassAvg: "669.48" xref: MassMono: "669.156072" xref: Origin: "K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01400 name: L-lysyl-poly(ADP-ribose) def: "A protein modification that effectively converts an L-lysine residue to an L-lysyl-poly(ADP-ribose)." [PubMed:6772638, RESID:AA0477] synonym: "L-lysyl-poly(ADP-ribose)" EXACT RESID-name [] synonym: "MOD_RES Lysyl poly(ADP-ribose)" EXACT UniProt-feature [] synonym: "poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl] (2S)-2,6-diaminohexanoate" EXACT RESID-systematic [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "C 21 H 34 N 7 O 15 P 2" xref: MassAvg: "686.48" xref: MassMono: "686.158812" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01401 name: (2S,3S)-3-hydroxyasparagine def: "A protein modification that effectively converts an L-asparagine residue to a (2S,3S)-3-hydroxyasparagine." [ChEBI:50789, PubMed:11823643, PubMed:12042299, PubMed:12215170, PubMed:17573339, RESID:AA0478] subset: PSI-MOD-slim synonym: "(2S,3S)-2,4-diamino-3-hydroxy-4-oxobutanoic acid" EXACT RESID-alternate [] synonym: "(2S,3S)-2-amino-3-hydroxy-4-butanediamic acid" EXACT RESID-systematic [] synonym: "(2S,3S)-3-hydroxyasparagine" EXACT RESID-name [] synonym: "(3S)3HyAsn" EXACT PSI-MOD-label [] synonym: "L-threo-beta-hydroxyasparagine" EXACT RESID-alternate [] synonym: "MOD_RES (3S)-3-hydroxyasparagine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 4 H 6 N 2 O 3" xref: MassAvg: "130.10" xref: MassMono: "130.037842" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01688 ! 3-hydroxy-L-asparagine [Term] id: MOD:01402 name: (2S,3R,4R)-3,4-dihydroxyproline def: "A protein modification that effectively converts an L-proline residue to a (2S,3R,4R)-3,4-dihydroxyproline." [PubMed:6893271, RESID:AA0479] synonym: "(2S,3R,4R)-3,4-dihydroxyproline" EXACT RESID-name [] synonym: "(2S,3R,4R)-3,4-dihydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "2,3-trans-3,4-trans-3,4-dihydroxy-L-proline" EXACT RESID-alternate [] synonym: "2-alpha-3-beta-4-alpha-3,4-dihydroxyproline" EXACT RESID-alternate [] synonym: "MOD_RES (3R,4R)-3,4-dihydroxyproline" EXACT UniProt-feature [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00866 ! dihydroxylated proline [Term] id: MOD:01403 name: (2S)-4,5,5'-trihydroxyleucine def: "A protein modification that effectively converts an L-leucine residue to a (2S)-4,5,5'-trihydroxyleucine." [PubMed:6893271, RESID:AA0480] synonym: "(2S)-2-amino-4,5-dihydroxy-4-(hydroxymethyl)pentanoic acid" EXACT RESID-systematic [] synonym: "(2S)-4,5,5'-trihydroxyleucine" EXACT RESID-name [] synonym: "4,5,5'-trihydroxyleucine" EXACT RESID-alternate [] synonym: "gamma,delta,delta'-trihydroxyleucine" EXACT RESID-alternate [] synonym: "MOD_RES 4,5,4'-trihydroxyleucine" EXACT UniProt-feature [] xref: DiffAvg: "48.00" xref: DiffFormula: "C 0 H 0 N 0 O 3" xref: DiffMono: "47.984744" xref: Formula: "C 6 H 11 N 1 O 4" xref: MassAvg: "161.16" xref: MassMono: "161.068808" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01413 ! trihydroxylated leucine [Term] id: MOD:01404 name: L-asparagine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue to form L-asparagine thiazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0481] comment: Cross-link 2. synonym: "2-[(1S)-1,3-diamino-3-oxopropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1,3-bisazanyl-3-oxopropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Asn-Cys)" EXACT UniProt-feature [] synonym: "L-asparagine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 7 H 7 N 3 O 2 S 1" xref: MassAvg: "197.21" xref: MassMono: "197.025897" xref: Origin: "C, N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01405 name: L-proline thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-proline residue to form L-proline thiazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0482] comment: Cross-link 2. synonym: "2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Pro-Cys)" EXACT UniProt-feature [] synonym: "L-proline thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 8 H 8 N 2 O 1 S 1" xref: MassAvg: "180.22" xref: MassMono: "180.035734" xref: Origin: "C, P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01406 name: L-threonine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazole-4-carboxylic acid." [PubMed:11320328, RESID:AA0483] comment: Cross-link 2. synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Thr-Cys)" EXACT UniProt-feature [] synonym: "L-threonine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 7 H 8 N 2 O 2 S 1" xref: MassAvg: "184.21" xref: MassMono: "184.030649" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01407 name: L-phenylalanine thiazoline-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazoline-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0484] comment: Cross-link 2. synonym: "(4R)-2-[(1S)-1-amino-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazoline-4-carboxylic acid (Phe-Cys)" EXACT UniProt-feature [] synonym: "L-phenylalanine thiazoline-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 12 H 12 N 2 O 1 S 1" xref: MassAvg: "232.30" xref: MassMono: "232.067034" xref: Origin: "C, F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues [Term] id: MOD:01408 name: L-threonine thiazoline-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazoline-4-carboxylic acid." [PubMed:11320328, RESID:AA0485] comment: Cross-link 2. synonym: "(4S)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[1-azanyl-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK (4S)-thiazoline-4-carboxylic acid (Thr-Cys)" EXACT UniProt-feature [] synonym: "L-threonine (4S)-thiazoline-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 7 H 10 N 2 O 2 S 1" xref: MassAvg: "186.23" xref: MassMono: "186.046299" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues [Term] id: MOD:01409 name: trihydroxylated residue def: "A protein modification that effectively replaces three hydrogen atoms with three hydroxyl groups." [PubMed:18688235] synonym: "Hy3Res" EXACT PSI-MOD-label [] xref: DiffAvg: "48.00" xref: DiffFormula: "C 0 H 0 N 0 O 3" xref: DiffMono: "47.984744" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue [Term] id: MOD:01410 name: hydroxylated leucine def: "A protein modification that effectively converts an L-leucine residue to an hydroxylated leucine." [PubMed:18688235] synonym: "HyLeu" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "L" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue is_a: MOD:00911 ! modified L-leucine residue [Term] id: MOD:01411 name: monohydroxylated leucine def: "A protein modification that effectively converts an L-leucine residue to a monohydroxylated leucine." [PubMed:18688235] synonym: "Hy1Leu" EXACT PSI-MOD-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 11 N 1 O 2" xref: MassAvg: "129.16" xref: MassMono: "129.078979" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:01410 ! hydroxylated leucine [Term] id: MOD:01412 name: dihydroxylated leucine def: "A protein modification that effectively converts an L-leucine residue to a dihydroxylated leucine." [PubMed:18688235] synonym: "Hy2Leu" EXACT PSI-MOD-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 6 H 11 N 1 O 3" xref: MassAvg: "145.16" xref: MassMono: "145.073893" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00428 ! dihydroxylated residue is_a: MOD:01410 ! hydroxylated leucine [Term] id: MOD:01413 name: trihydroxylated leucine def: "A protein modification that effectively converts an L-leucine residue to a trihydroxylated leucine." [PubMed:18688235] synonym: "Hy3Leu" EXACT PSI-MOD-label [] xref: DiffAvg: "48.00" xref: DiffFormula: "C 0 H 0 N 0 O 3" xref: DiffMono: "47.984744" xref: Formula: "C 6 H 11 N 1 O 4" xref: MassAvg: "161.16" xref: MassMono: "161.068808" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01409 ! trihydroxylated residue is_a: MOD:01410 ! hydroxylated leucine [Term] id: MOD:01414 name: hydroxylated isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to an hydroxylated isoleucine." [PubMed:18688235] synonym: "HyIle" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "I" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue is_a: MOD:00910 ! modified L-isoleucine residue [Term] id: MOD:01415 name: monohydroxylated isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to a monohydroxylated isoleucine." [PubMed:18688235] synonym: "Hy1Ile" EXACT PSI-MOD-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 11 N 1 O 2" xref: MassAvg: "129.16" xref: MassMono: "129.078979" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:01414 ! hydroxylated isoleucine [Term] id: MOD:01416 name: dihydroxylated isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to a dihydroxylated isoleucine." [PubMed:18688235] synonym: "Hy2Ile" EXACT PSI-MOD-label [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 6 H 11 N 1 O 3" xref: MassAvg: "145.16" xref: MassMono: "145.073893" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00428 ! dihydroxylated residue is_a: MOD:01414 ! hydroxylated isoleucine [Term] id: MOD:01417 name: monomethylated proline def: "A protein modification that effectively converts an L-proline residue to a monomethylated proline." [PubMed:18688235] subset: PSI-MOD-slim synonym: "Me1Pro" EXACT PSI-MOD-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 6 H 10 N 1 O 1" xref: MassAvg: "112.15" xref: MassMono: "112.076239" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00712 ! methylated proline [Term] id: MOD:01418 name: methylated threonine def: "A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine." [PubMed:18688235] synonym: "MeThr" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00427 ! methylated residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01419 name: oxazole/oxazoline ring crosslinked residues def: "A protein modification that crosslinks two residues by condensation of a serine or threonine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring, or by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid." [PubMed:18688235] is_a: MOD:00690 ! oxazole/thiazole ring crosslinked residues [Term] id: MOD:01420 name: thiazole/thiazoline ring croslinked residues def: "A protein modification that crosslinks two residues by condensation of a cysteine thiol with the carbonyl of the preceding residue to form a thiazole or thiazoline ring." [PubMed:18688235] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00687 ! thioether crosslinked residues is_a: MOD:00690 ! oxazole/thiazole ring crosslinked residues [Term] id: MOD:01421 name: oxazole/oxazoline ring crosslinked residues (Ser) def: "A protein modification that crosslinks two residues by condensation of a serine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring." [PubMed:18688235] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues [Term] id: MOD:01422 name: oxazole/oxazoline ring crosslinked residues (Thr) def: "A protein modification that crosslinks two residues by condensation of a threonine hydroxyl with the carbonyl of the preceding residue to form a 5-methyloxazole or 5-methyloxazoline ring." [PubMed:18688235] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues [Term] id: MOD:01423 name: palmitoleylated residue def: "A protein modification that effectively replaces a hydrogen atom with a palmitoleyl group." [UniMod:431] subset: PSI-MOD-slim xref: DiffAvg: "236.40" xref: DiffFormula: "C 16 H 28 N 0 O 1" xref: DiffMono: "236.214016" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue [Term] id: MOD:01424 name: quinaldate modified residue def: "A protein modification that effectively results from forming an adduct with a compound containing a quinaldate, kynurenate, or xanthurenate group." [PubMed:18688235] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01425 name: pyridinyl ring crosslinked residues def: "A protein modification that crosslinks three residues by formation of a pyridinyl ring, such as pyridine-2,5-dicarboxylic acid or 5-aminopiperideine-2,5-dicarboxylic acid." [PubMed:18688235] comment: Cross-link 3. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C, S, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00033 ! crosslinked residues is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01426 name: isotope tagged reagent derivatized residue def: "A protein modification that forms an adduct with a particular isotope labeled compound used as a reagent." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01427 name: 2-aminobutanoic acid (Abu) def: "OBSOLETE because redundant and identical to MOD:00819. Remap to MOD:00819." [PubMed:18688235] synonym: "Abu" EXACT DeltaMass-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 4 H 7 N 1 O 1" xref: MassAvg: "85.11" xref: MassMono: "85.052764" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01428 name: (13)C isotope tagged reagent def: "A protein modification that forms an adduct with a (13)C labeled compound used as a reagent." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01429 name: (15)N isotope tagged reagent def: "A protein modification that forms an adduct with a (15)N labeled compound used as a reagent." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01430 name: (18)O isotope tagged reagent def: "A protein modification that forms an adduct with a (13)C labeled compound used as a reagent." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01431 name: (2)H deuterium tagged reagent def: "A protein modification that forms an adduct with a (2)H labeled compound used as a reagent." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01432 name: (2S,4S)-4,5-dihydroxyleucine def: "A protein modification that effectively converts an L-leucine residue to a (2S,4S)-4,5-dihydroxyleucine." [PubMed:3718926, RESID:AA0446] synonym: "(2S,4S)-2-amino-4,5-dihydroxy-4-methylpentanoic acid" EXACT RESID-systematic [] synonym: "(2S,4S)-4,5-dihydroxyleucine" EXACT RESID-name [] synonym: "(4S)-4,5-dihydroxyleucine" EXACT RESID-alternate [] synonym: "gamma,delta-dihydroxyleucine" EXACT RESID-alternate [] xref: DiffAvg: "32.00" xref: DiffFormula: "C 0 H 0 N 0 O 2" xref: DiffMono: "31.989829" xref: Formula: "C 6 H 11 N 1 O 3" xref: MassAvg: "145.16" xref: MassMono: "145.073893" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01412 ! dihydroxylated leucine [Term] id: MOD:01433 name: 1-amino-2-propanone def: "A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanone." [ChEBI:17906, PubMed:12715872, PubMed:19196969, RESID:AA0486] synonym: "1-amino-2-propanone" EXACT RESID-name [] synonym: "1-aminopropan-2-one" EXACT RESID-alternate [] synonym: "1-aminopropanone" EXACT RESID-systematic [] synonym: "aminoacetone" EXACT RESID-alternate [] synonym: "MOD_RES 1-amino-2-propanone" EXACT UniProt-feature [] xref: DiffAvg: "-46.03" xref: DiffFormula: "C -1 H -2 N 0 O -2" xref: DiffMono: "-46.005479" xref: Formula: "C 3 H 6 N 1 O 1" xref: MassAvg: "72.09" xref: MassMono: "72.044939" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00683 ! dehydrogenated residue is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:00960 ! decarboxylated residue [Term] id: MOD:01434 name: 4-hydroxy-L-glutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to a 4-hydroxy-L-glutamic acid." [PubMed:893891, RESID:AA0487] synonym: "(2S,4Xi)-2-amino-4-hydroxypentanedioic acid" EXACT RESID-systematic [] synonym: "4-hydroxy-L-glutamic acid" EXACT RESID-name [] synonym: "gamma-hydroxy glutaminic acid" EXACT RESID-alternate [] synonym: "MOD_RES 4-hydroxyglutamate" EXACT UniProt-feature [] synonym: "threo-4-hydroxy-L-glutamic acid" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 7 N 1 O 4" xref: MassAvg: "145.11" xref: MassMono: "145.037508" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01435 name: 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole def: "A protein modification that effectively results from forming an adduct between a cysteine residue, a glutamic acid residue and the indole compound 2-carboxy-3-methyl-4-hydroxymethyl--indole." [PubMed:893891, RESID:AA0488] comment: Cross-link 2. synonym: "2-([(1R)-1-amino-1-carboxyeth-2-yl]sulfanyl)carbonyl-3-methyl-4-([(1S)-1-amino-1-carboxy-4-oxobutan-4-yl]oxy)methyl-1H-indole" EXACT RESID-systematic [] synonym: "2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole" EXACT RESID-name [] synonym: "2-(cystein-S-ylcarbonyl)-4-[(glutam-5-yloxy)methyl]-3-methyl-1H-indole" EXACT RESID-alternate [] synonym: "BINDING 3-methyl-4-hydroxymethylindole-2-carboxylic acid (covalent; via 2 links)" EXACT UniProt-feature [] xref: DiffAvg: "169.18" xref: DiffFormula: "C 11 H 7 N 1 O 1 S 0" xref: DiffMono: "169.052764" xref: Formula: "C 19 H 19 N 3 O 5 S 1" xref: MassAvg: "401.44" xref: MassMono: "401.104542" xref: Origin: "C, E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00672 ! S-acylated residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01436 name: cyclo[(prolylserin)-O-yl] cysteinate (Cys) def: "A protein modification that effectively converts an L-cysteine residue to cyclo[(prolylserin)-O-yl] cysteinate." [PubMed:7961166, RESID:AA0489#CYS] synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate [] synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic [] synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name [] synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature [] xref: DiffAvg: "166.18" xref: DiffFormula: "C 8 H 10 N 2 O 2 S 0" xref: DiffMono: "166.074228" xref: Formula: "C 11 H 16 N 3 O 4 S 1" xref: MassAvg: "286.33" xref: MassMono: "286.086152" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01629 ! cyclo[(prolylserin)-O-yl] cysteinate [Term] id: MOD:01437 name: cyclo[(prolylserin)-O-yl] cysteinate (Cys-Pro-Ser cross-link) def: "A protein modification that effectively converts an L-cysteine residue, an L-proline residue, and an L-serine residue to cyclo[(prolylserin)-O-yl] cysteinate." [PubMed:7961166, RESID:AA0489#TRI] comment: Cross-link 3. synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate [] synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic [] synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name [] synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 11 H 16 N 3 O 4 S 1" xref: MassAvg: "286.33" xref: MassMono: "286.086152" xref: Origin: "C, P, S" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01629 ! cyclo[(prolylserin)-O-yl] cysteinate [Term] id: MOD:01438 name: S-[2-(pyridin-2-yl)ethyl]-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-2-yl)ethyl]-L-cysteine." [PubMed:18369855, PubMed:18688235] comment: From DeltaMass: (name misspelled "Pyridylethyl Cystenyl", and formula incorrect, N and O reversed) Formula: C10H12O2N1S1 Monoisotopic Mass Change: 208.067 Average Mass Change: 208.286 synonym: "2-PEC" EXACT PSI-MOD-alternate [] synonym: "2-vinylpyridine derivatized cysteine residue" EXACT PSI-MOD-alternate [] synonym: "Pyridylethyl" RELATED PSI-MS-label [] synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label [] synonym: "S-(pyridin-2-ylethyl)-L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S-pyridylethylation" RELATED UniMod-description [] xref: DiffAvg: "105.14" xref: DiffFormula: "C 7 H 7 N 1" xref: DiffMono: "105.057849" xref: Formula: "C 10 H 12 N 2 O 1 S 1" xref: MassAvg: "208.28" xref: MassMono: "208.067034" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00424 ! S-pyridylethyl-L-cysteine [Term] id: MOD:01439 name: S-[2-(pyridin-4-yl)ethyl]-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-4-yl)ethyl]-L-cysteine." [PubMed:18688235, PubMed:6528972] synonym: "4-PEC" EXACT PSI-MOD-alternate [] synonym: "Pyridylethyl" RELATED PSI-MS-label [] synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label [] synonym: "S-(pyridin-4-ylethyl)-L-cysteine" EXACT PSI-MOD-alternate [] synonym: "S-pyridylethylation" RELATED UniMod-description [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00424 ! S-pyridylethyl-L-cysteine [Term] id: MOD:01440 name: glutamyl semialdehyde def: "A protein modification that effectively converts a source amino acid residue to an L-glutamyl semialdehyde." [PubMed:18688235] synonym: "(S)-2-amino-5-oxopentanoic acid" EXACT PSI-MOD-alternate [] synonym: "L-glutamic gamma-semialdehyde" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 5 H 7 N 1 O 2" xref: MassAvg: "113.12" xref: MassMono: "113.047678" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01441 name: natural, standard, encoded residue def: "A protein modification that inserts or replaces a residue with a natural, standard, encoded residue." [PubMed:18688235, PubMed:6692818] subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00009 ! natural residue [Term] id: MOD:01442 name: 3-(O4'-L-tyrosyl)-L-valine def: "A protein modification that effectively cross-links an L-valine residue and an L-tyrosine residue by an ether bond to form 3-(O4'-L-tyrosyl)-L-valine." [PubMed:19321420, RESID:AA0490] comment: Cross-link 2. synonym: "(2S)-2-amino-3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-3-methylbutanoic acid" EXACT RESID-systematic [] synonym: "3-(O4'-L-tyrosyl)-L-valine" EXACT RESID-name [] synonym: "CROSSLNK 3-(O4'-tyrosyl)-valine (Val-Tyr)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 14 H 16 N 2 O 3" xref: MassAvg: "260.29" xref: MassMono: "260.116092" xref: Origin: "V, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:00920 ! modified L-valine residue [Term] id: MOD:01443 name: tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide def: "A protein modification that effectively converts four L-glutamic acid residues and two L-histidine residues to tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide." [PubMed:19321420, RESID:AA0491] comment: Cross-link 6. It is not clear whether the lipid carboxylate is a cofactor or a substrate, and its identity is not certain. It was modeled as myristic acid [JSG]. xref: DiffAvg: "350.12" xref: DiffFormula: "C 14 Fe 1 H 23 Mn 1 N 0 O 3" xref: DiffMono: "350.038251" xref: FormalCharge: "1-" xref: Formula: "C 46 Fe 1 H 65 Mn 1 N 10 O 17" xref: MassAvg: "1140.86" xref: MassMono: "1140.326447" xref: Origin: "E, E, E, E, H, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00438 ! myristoylated residue is_a: MOD:00738 ! iron containing modified residue is_a: MOD:00740 ! manganese containing modified residue is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00909 ! modified L-histidine residue [Term] id: MOD:01444 name: L-3,3-dihydroxyoalanine (Cys) def: "A protein modification that effectively converts an L-cysteine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492#CYS] synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic [] synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate [] synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name [] synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate [] synonym: "3-hydroxy-L-serine" EXACT RESID-alternate [] synonym: "3-oxoalanine hydrate" EXACT RESID-alternate [] synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer [] xref: DiffAvg: "-0.06" xref: DiffFormula: "C 0 H 0 N 0 O 2 S -1" xref: DiffMono: "0.017758" xref: Formula: "C 3 H 5 N 1 O 3" xref: MassAvg: "103.08" xref: MassMono: "103.026943" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01448 ! L-3,3-dihydroxyoalanine [Term] id: MOD:01445 name: L-3,3-dihydroxyoalanine (Ser) def: "A protein modification that effectively converts an L-serine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492#SER] synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic [] synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate [] synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name [] synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate [] synonym: "3-hydroxy-L-serine" EXACT RESID-alternate [] synonym: "3-oxoalanine hydrate" EXACT RESID-alternate [] synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 3 H 5 N 1 O 3" xref: MassAvg: "103.08" xref: MassMono: "103.026943" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01448 ! L-3,3-dihydroxyoalanine [Term] id: MOD:01446 name: N-(dihydroxymethyl)-L-methionine (fMet) def: "A protein modification that effectively converts an N-formyl-Lmethionine residue to N-(dihydroxymethyl)-L-methionine." [PubMed:12595263, PubMed:9159480, RESID:AA0493] synonym: "(2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "N-(dihydroxymethyl)-L-methionine" EXACT RESID-name [] synonym: "N-formyl-L-methionine hydrate" EXACT RESID-alternate [] synonym: "N-orthoformylmethionine" EXACT RESID-alternate [] xref: DiffAvg: "18.02" xref: DiffFormula: "C 0 H 2 N 0 O 1 S 0" xref: DiffMono: "18.010565" xref: Formula: "C 6 H 12 N 1 O 3 S 1" xref: MassAvg: "178.23" xref: MassMono: "178.053789" xref: Origin: "MOD:00030" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:01450 ! modified N-formyl-L-methionine residue relationship: derives_from MOD:00030 ! N-formyl-L-methionine residue [Term] id: MOD:01447 name: N-(dihydroxymethyl)-L-methionine (Met) def: "A protein modification that effectively converts an L-methionine residue to N-(dihydroxymethyl)-L-methionine (not known as a natural, post-translational modification process)." [PubMed:12595263, PubMed:9159480, RESID:AA0493] comment: This entry is for the artifactual formation of N-(dihydroxymethyl)-L-methionine from methionine. For N-(dihydroxymethyl)-L-methionine derived from encoded N-formyl-L-methionine, use MOD:01446. synonym: "(2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "N-(dihydroxymethyl)-L-methionine" EXACT RESID-name [] synonym: "N-formyl-L-methionine hydrate" EXACT RESID-alternate [] synonym: "N-orthoformylmethionine" EXACT RESID-alternate [] xref: DiffAvg: "46.03" xref: DiffFormula: "C 1 H 2 N 0 O 2 S 0" xref: DiffMono: "46.005479" xref: Formula: "C 6 H 12 N 1 O 3 S 1" xref: MassAvg: "178.23" xref: MassMono: "178.053789" xref: Origin: "M" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:01448 name: L-3,3-dihydroxyoalanine def: "A protein modification that effectively converts a source amino acid residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492] synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic [] synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate [] synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name [] synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate [] synonym: "3-hydroxy-L-serine" EXACT RESID-alternate [] synonym: "3-oxoalanine hydrate" EXACT RESID-alternate [] synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 3 H 5 N 1 O 3" xref: MassAvg: "103.08" xref: MassMono: "103.026943" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01449 name: L-3,3-dihydroxyoalanine (Oxoalanine) def: "A protein modification that effectively converts an L-3-oxoalanine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, PubMed:18688235] xref: DiffAvg: "18.02" xref: DiffFormula: "C 0 H 2 N 0 O 1" xref: DiffMono: "18.010565" xref: Formula: "C 3 H 5 N 1 O 3" xref: MassAvg: "103.08" xref: MassMono: "103.026943" xref: Origin: "MOD:01169" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01448 ! L-3,3-dihydroxyoalanine relationship: derives_from MOD:01169 ! L-3-oxoalanine [Term] id: MOD:01450 name: modified N-formyl-L-methionine residue def: "A protein modification that modifies an N-formyl-L-methionine residue." [PubMed:18688235] xref: Origin: "MOD:00030" xref: TermSpec: "N-term" is_a: MOD:01157 ! protein modification categorized by amino acid modified relationship: derives_from MOD:00030 ! N-formyl-L-methionine residue [Term] id: MOD:01451 name: O-phospho-L-serine arising from O-phosphopantetheine-L-serine after neutral loss of pantetheine def: "A protein modification that converts an L-serine residue to O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine." [PubMed:17042494, PubMed:18688235] comment: Phosphoserine is generated and detected after the facile elimination of pantetheine from the phosphopantetheine tertiary phosphodiester. See MOD:01452 for alternate origin. subset: PSI-MOD-slim xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 3 H 6 N 1 O 5 P 1" xref: MassAvg: "167.06" xref: MassMono: "166.998359" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00046 ! O-phospho-L-serine is_a: MOD:00431 ! modified residue with a secondary neutral loss relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine [Term] id: MOD:01452 name: O-phosphopantetheine-L-serine with neutral loss of pantetheine def: "Covalent modification of a peptide or protein amino acid O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine." [PubMed:17042494, PubMed:18688235] comment: Phosphoserine is generated and detected after the facile elimination of pantethiene from the phosphopantethiene tertiary phosphodiester. See MOD:01451 for alternate origin. subset: PSI-MOD-slim xref: DiffAvg: "-260.35" xref: DiffFormula: "C -11 H -20 N -2 O -3 P 0 S -1" xref: DiffMono: "-260.119464" xref: Formula: "C 3 H 6 N 1 O 5 P 1" xref: MassAvg: "167.06" xref: MassMono: "166.998359" xref: Origin: "MOD:00159" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00046 ! O-phospho-L-serine is_a: MOD:00431 ! modified residue with a secondary neutral loss relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine [Term] id: MOD:01453 name: L-glutamic acid 5-methyl ester def: "A protein modification that effectively converts a source amino acid residue to L-glutamate 5-methyl ester." [RESID:AA0072] subset: PSI-MOD-slim synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate [] synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate [] synonym: "5-methyl esterified L-glutamic acid" EXACT PSI-MOD-alternate [] synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate [] synonym: "5-methyl L-glutamate" EXACT RESID-alternate [] synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate [] synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate [] synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name [] synonym: "O-methyl Glutamyl" EXACT DeltaMass-label [] synonym: "O5MeGlu" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 9 N 1 O 3" xref: MassAvg: "143.14" xref: MassMono: "143.058243" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00393 ! O-methylated residue is_a: MOD:00599 ! monomethylated residue is_a: MOD:00713 ! methylated glutamic acid is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01454 name: N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium def: "A protein modification that effectively crosslinks an N-terminal L-proline residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium." [PubMed:10833024, PubMed:11847126, PubMed:9030608, RESID:AA0494] comment: This linkage is not a Schiff-base [JSG]. synonym: "(1Z,2S)-2-carboxy-1-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]pyrrolidinium" EXACT RESID-systematic [] synonym: "DNA glycosylase proline Schiff base intermediate" RELATED RESID-misnomer [] synonym: "N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium" EXACT RESID-name [] xref: DiffAvg: "179.09" xref: DiffFormula: "C 5 H 8 N 0 O 5 P 1" xref: DiffMono: "179.010386" xref: FormalCharge: "1+" xref: Formula: "C 10 H 16 N 1 O 6 P 1" xref: MassAvg: "277.21" xref: MassMono: "277.070975" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00750 ! deoxyribonucleic acid linked residue is_a: MOD:00915 ! modified L-proline residue [Term] id: MOD:01455 name: O-phosphorylated residue def: "A protein modification that effectively replaces a residue hydroxyl or carboxyl hydrogen with a phosphono group (H2PO3 or 'phosphate')." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OPhosRes" EXACT PSI-MOD-label [] xref: DiffAvg: "79.98" xref: DiffFormula: "H 1 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00696 ! phosphorylated residue [Term] id: MOD:01456 name: N-phosphorylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with a phosphono group (H2PO3 or 'phosphate')." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OPhosRes" EXACT PSI-MOD-label [] xref: DiffAvg: "79.98" xref: DiffFormula: "H 1 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00696 ! phosphorylated residue [Term] id: MOD:01457 name: L-cysteine (Ser) def: "A protein modification that effectively converts an L-serine residue to L-cysteine (not known as a natural, post-translational modification process)." [PubMed:1849824, PubMed:18688235] synonym: "Cys(Ser)" EXACT PSI-MOD-label [] xref: DiffAvg: "-16.06" xref: DiffFormula: "C 0 H 0 N 0 O 1 S -1" xref: DiffMono: "-15.977156" xref: Formula: "C 3 H 5 N 1 O 1 S 1" xref: MassAvg: "103.14" xref: MassMono: "103.009185" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00014 ! L-cysteine residue is_a: MOD:00749 ! sulfur substitution for oxygen is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01458 name: alpha-amino acetylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acetyl group." [OMSSA:10, UniMod:1#N-term] subset: PSI-MOD-slim synonym: "N2AcRes" EXACT PSI-MOD-label [] synonym: "ntermacetyl" EXACT OMSSA-label [] xref: DiffAvg: "42.04" xref: DiffFormula: "C 2 H 2 N 0 O 1" xref: DiffMono: "42.010565" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00408 ! N-acetylated residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:01459 name: 4x(2)H labeled alpha-dimethylamino N-terminal residue def: "A protein modification that effectively converts an N-terminal residue to an 4x(2)H labeled alpha-dimethylamino N-terminal residue." [OMSSA:190, PubMed:14670044, UniMod:199#N-term] comment: Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. subset: PSI-MOD-slim synonym: "DiMethyl-CHD2" RELATED UniMod-description [] synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label [] synonym: "mod190" EXACT OMSSA-label [] xref: DiffAvg: "32.06" xref: DiffFormula: "C 2 (2)H 4" xref: DiffMono: "32.056407" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00552 ! 4x(2)H labeled dimethylated residue [Term] id: MOD:01460 name: alpha-amino methylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a methyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "N2MeRes" EXACT PSI-MOD-label [] xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00602 ! N-methylated residue [Term] id: MOD:01461 name: N-methylated alanine def: "A protein modification that effectively replaces an L-alanine alpha amino hydrogen with a methyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00665 ! methylated alanine is_a: MOD:01460 ! alpha-amino methylated residue [Term] id: MOD:01462 name: N-methylated proline def: "A protein modification that effectively replaces an L-proline alpha imino hydrogen with a methyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00712 ! methylated proline is_a: MOD:01460 ! alpha-amino methylated residue [Term] id: MOD:01463 name: N-methylated methionine def: "A protein modification that effectively replaces an L-methionine alpha amino hydrogen with a methyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00716 ! methylated methionine is_a: MOD:01460 ! alpha-amino methylated residue [Term] id: MOD:01464 name: protonated L-methionine (L-methioninium) residue def: "A protein modification that effectively converts an L-methionine residue to an L-methioninium (protonated L-methionine)." [PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "1.01" xref: DiffFormula: "C 0 H 1 N 0 O 0 S 0" xref: DiffMono: "1.007276" xref: FormalCharge: "1+" xref: Formula: "C 5 H 11 N 1 O 1 S 1" xref: MassAvg: "133.21" xref: MassMono: "133.055586" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01700 ! alpha-amino protonated residue [Term] id: MOD:01465 name: N,N,N-trimethyl-L-methionine (from L-methioninium) def: "A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to an N6,N6,N6-trimethyl-L-methionine." [PubMed:18688235] comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Met process (MOD:01382) accounts for both protonation and trimethylation. subset: PSI-MOD-slim synonym: "N2Me3Met" EXACT PSI-MOD-label [] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6 N 0 O 0 S 0" xref: DiffMono: "42.046402" xref: FormalCharge: "1+" xref: Formula: "C 8 H 17 N 1 O 1 S 1" xref: MassAvg: "175.29" xref: MassMono: "175.102537" xref: Origin: "MOD:001464" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01687 ! alpha-amino trimethylated residue relationship: derives_from MOD:01464 ! protonated L-methionine (L-methioninium) residue [Term] id: MOD:01466 name: menadione quinone derivative - site C def: "modification from UniMod Chemical derivative" [PubMed:15939799, UniMod:302#K] synonym: "Menadione" RELATED UniMod-interim [] synonym: "Menadione quinone derivative" RELATED UniMod-description [] xref: DiffAvg: "170.17" xref: DiffFormula: "C 11 H 6 O 2" xref: DiffMono: "170.036779" xref: Formula: "C 14 H 11 N 1 O 3 S 1" xref: MassAvg: "273.31" xref: MassMono: "273.045964" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00621 ! menadione quinone derivative is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01467 name: menadione quinone derivative - site K def: "modification from UniMod Chemical derivative" [PubMed:15939799, UniMod:302#K] synonym: "Menadione" RELATED UniMod-interim [] synonym: "Menadione quinone derivative" RELATED UniMod-description [] xref: DiffAvg: "170.17" xref: DiffFormula: "C 11 H 6 O 2" xref: DiffMono: "170.036779" xref: Formula: "C 17 H 18 N 2 O 3" xref: MassAvg: "298.34" xref: MassMono: "298.131742" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00621 ! menadione quinone derivative is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01468 name: L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Cys) def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process)." [PubMed:14235557, PubMed:2211698, PubMed:8052647, PubMed:9036855, RESID:AA0248#CYS, UniMod:415] comment: This entry is for the artifactual formation of L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00253. synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate [] synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-selenocysteinyl-Se-molybdenum" EXACT RESID-systematic [] synonym: "formate dehydrogenase selenocysteine molybdenum cofactor" EXACT RESID-alternate [] synonym: "L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" RELATED UniMod-description [] synonym: "L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name [] synonym: "molybdopterin-se" RELATED UniMod-interim [] synonym: "MolybdopterinGD+Delta:S(-1)Se(1)" RELATED PSI-MS-label [] xref: DiffAvg: "1618.93" xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 3 Se 1" xref: DiffMono: "1620.930226" xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1" xref: MassAvg: "1722.07" xref: MassMono: "1723.939410" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00744 ! molybdenum pterin containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01469 name: L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Cys) def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process)." [PubMed:11372198, PubMed:12220497, RESID:AA0376#CYS] comment: This entry is for the artifactual formation of L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00381. xref: DiffAvg: "1738.88" xref: DiffFormula: "C 40 H 47 N 20 O 26 P 4 S 4 Se 1 W 1" xref: DiffMono: "1738.947820" xref: Formula: "C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1" xref: MassAvg: "1842.02" xref: MassMono: "1841.957004" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00746 ! tungsten containing modified residue is_a: MOD:00748 ! pterin modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01470 name: (E)-dehydrobutyrine (Thr) def: "A protein modification that effectively converts an L-threonine residue to (E)-dehydrobutyrine." [DeltaMass:0, PubMed:1547888, PubMed:20805503, PubMed:3769923, RESID:AA0547] subset: PSI-MOD-slim synonym: "(2E)-2-aminobut-2-enoic acid" EXACT RESID-systematic [] synonym: "(E)-2-amino-2-butenoic acid" EXACT RESID-alternate [] synonym: "(E)-2-aminobutenoic acid" EXACT RESID-alternate [] synonym: "(E)-dehydrobutyrine" EXACT RESID-name [] synonym: "(E)dHAbu" EXACT PSI-MOD-label [] synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate [] synonym: "3-methyldehydroalanine" EXACT RESID-alternate [] synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate [] synonym: "anhydrothreonine" EXACT RESID-alternate [] synonym: "Dehydrated" RELATED UniMod-interim [] synonym: "Dehydration" RELATED UniMod-description [] synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label [] synonym: "Dhb" EXACT RESID-alternate [] synonym: "methyl-dehydroalanine" EXACT RESID-alternate [] synonym: "MOD_RES (E)-2,3-didehydrobutyrine" EXACT UniProt-feature [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 4 H 5 N 1 O 1" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00190 ! dehydrobutyrine (Thr) [Term] id: MOD:01471 name: (Z)-dehydrobutyrine (Thr) def: "A protein modification that effectively converts an L-threonine residue to (Z)-dehydrobutyrine." [DeltaMass:0, PubMed:1547888, PubMed:3769923, RESID:AA0182] subset: PSI-MOD-slim synonym: "(2Z)-2-aminobut-2-enoic acid" EXACT RESID-systematic [] synonym: "(Z)-2-amino-2-butenoic acid" EXACT RESID-alternate [] synonym: "(Z)-2-aminobutenoic acid" EXACT RESID-alternate [] synonym: "(Z)-dehydrobutyrine" EXACT RESID-name [] synonym: "(Z)dHAbu" EXACT PSI-MOD-label [] synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate [] synonym: "3-methyldehydroalanine" EXACT RESID-alternate [] synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate [] synonym: "anhydrothreonine" EXACT RESID-alternate [] synonym: "Dehydrated" RELATED UniMod-interim [] synonym: "Dehydration" RELATED UniMod-description [] synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label [] synonym: "Dhb" EXACT RESID-alternate [] synonym: "methyl-dehydroalanine" EXACT RESID-alternate [] synonym: "MOD_RES (Z)-2,3-didehydrobutyrine" EXACT UniProt-feature [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 4 H 5 N 1 O 1" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00190 ! dehydrobutyrine (Thr) [Term] id: MOD:01472 name: reduced residue def: "A protein modification that effectively either adds neutral hydrogen atoms (proton and electron), or removes oxygen atoms from a residue with or without the addition of hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim synonym: "RedRes" EXACT PSI-MOD-label [] is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01473 name: hydrogenated residue def: "A protein modification that effectively adds neutral hydrogen atoms (proton and electron) to a residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "HRes" EXACT PSI-MOD-label [] is_a: MOD:01472 ! reduced residue [Term] id: MOD:01474 name: O-[S-(carboxymethyl)phosphopantetheine]-L-serine def: "A protein modification that effectively converts an L-serine residue to O-[S-(carboxymethyl)phosphopantetheine]-L-serine." [PubMed:18688235] comment: This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetic acid [JSG]. xref: DiffAvg: "398.37" xref: DiffFormula: "C 13 H 23 N 2 O 8 P 1 S 1" xref: DiffMono: "398.091273" xref: Formula: "C 16 H 28 N 3 O 10 P 1 S 1" xref: MassAvg: "485.44" xref: MassMono: "485.123302" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00399 ! iodoacetic acid derivatized residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine [Term] id: MOD:01475 name: O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine def: "A protein modification that effectively converts an L-serine residue to O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine." [PubMed:18688235] comment: This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetamide [JSG]. xref: DiffAvg: "397.38" xref: DiffFormula: "C 13 H 24 N 3 O 7 P 1 S 1" xref: DiffMono: "397.107258" xref: Formula: "C 16 H 29 N 4 O 9 P 1 S 1" xref: MassAvg: "484.46" xref: MassMono: "484.139286" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine [Term] id: MOD:01476 name: 2'-fluoro-L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to an 2'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898] synonym: "2-fluorophenylalanine" EXACT PSI-MOD-alternate [] synonym: "o-fluorophenylalanine" EXACT PSI-MOD-alternate [] synonym: "ortho-fluorophenylalanine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "17.99" xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" xref: DiffMono: "17.990578" xref: Formula: "C 9 F 1 H 8 N 1 O 1" xref: MassAvg: "165.17" xref: MassMono: "165.058992" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01227 ! monofluorinated L-phenylalanine [Term] id: MOD:01477 name: 3'-fluoro-L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue to an 3'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898] synonym: "3-fluorophenylalanine" EXACT PSI-MOD-alternate [] synonym: "m-fluorophenylalanine" EXACT PSI-MOD-alternate [] synonym: "meta-fluorophenylalanine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "17.99" xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" xref: DiffMono: "17.990578" xref: Formula: "C 9 F 1 H 8 N 1 O 1" xref: MassAvg: "165.17" xref: MassMono: "165.058992" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01227 ! monofluorinated L-phenylalanine [Term] id: MOD:01478 name: 4'-fluoro-L-phenylalanine def: "A protein modification that effectively converts an L-phenylalanine residue into an 4'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898] synonym: "4-fluorophenylalanine" EXACT PSI-MOD-alternate [] synonym: "p-fluorophenylalanine" EXACT PSI-MOD-alternate [] synonym: "para-fluorophenylalanine" EXACT PSI-MOD-alternate [] synonym: "rho-fluorophenylalanine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "17.99" xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" xref: DiffMono: "17.990578" xref: Formula: "C 9 F 1 H 8 N 1 O 1" xref: MassAvg: "165.17" xref: MassMono: "165.058992" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01227 ! monofluorinated L-phenylalanine [Term] id: MOD:01479 name: 4'-fluoro-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue into an 4'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898] synonym: "4-fluorotryptophan" EXACT PSI-MOD-alternate [] xref: DiffAvg: "17.99" xref: DiffFormula: "F 1 H -1" xref: DiffMono: "17.990578" xref: Formula: "C 11 F 1 H 9 N 2 O 1" xref: MassAvg: "204.20" xref: MassMono: "204.069891" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01226 ! monofluorinated L-tryptophan [Term] id: MOD:01480 name: 5'-fluoro-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue into an 5'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898] synonym: "5-fluorotryptophan" EXACT PSI-MOD-alternate [] xref: DiffAvg: "17.99" xref: DiffFormula: "F 1 H -1" xref: DiffMono: "17.990578" xref: Formula: "C 11 F 1 H 9 N 2 O 1" xref: MassAvg: "204.20" xref: MassMono: "204.069891" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01226 ! monofluorinated L-tryptophan [Term] id: MOD:01481 name: 6'-fluoro-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue into an 6'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898] synonym: "6-fluorotryptophan" EXACT PSI-MOD-alternate [] xref: DiffAvg: "17.99" xref: DiffFormula: "F 1 H -1" xref: DiffMono: "17.990578" xref: Formula: "C 11 F 1 H 9 N 2 O 1" xref: MassAvg: "204.20" xref: MassMono: "204.069891" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01226 ! monofluorinated L-tryptophan [Term] id: MOD:01482 name: calcium containing modified residue def: "A protein modification that effectively substitutes a calcium atom or a cluster containing calcium for hydrogen atoms, or that coordinates a calcium ion." [PubMed:18688235] subset: PSI-MOD-slim synonym: "CaRes" EXACT PSI-MOD-label [] is_a: MOD:00698 ! metal or metal cluster containing modified residue [Term] id: MOD:01483 name: O-formylated residue def: "A protein modification that effectively replaces a residue hydroxyl group with a formyloxy group." [PubMed:18688235] synonym: "OFoRes" EXACT PSI-MOD-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 O 1" xref: DiffMono: "27.994915" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00493 ! formylated residue is_a: MOD:00671 ! O-acylated residue [Term] id: MOD:01484 name: N6-(L-isoglutamyl)-L-lysine (Glu) def: "A protein modification that effectively crosslinks an L-glutamic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine and the release of water." [ChEBI:21863, PubMed:19015515, RESID:AA0124#GLU] comment: Cross-link 2. This cross-link is usually made by glutamine and releases ammonia, rather than glutamic acid and requiring the consumption of ATP. synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate [] synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate [] synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label [] synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate [] synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 11 H 17 N 3 O 3" xref: MassAvg: "239.27" xref: MassMono: "239.126991" xref: Origin: "K, E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01630 ! N6-(L-isoglutamyl)-L-lysine [Term] id: MOD:01485 name: iTRAQ4plex-114 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [UniMod:532] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 114" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ114" RELATED UniMod-interim [] synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] xref: DiffAvg: "144.11" xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" xref: DiffMono: "144.105919" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01430 ! (18)O isotope tagged reagent is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue [Term] id: MOD:01486 name: iTRAQ4plex-114 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:167, UniMod:532#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 114" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ114" RELATED UniMod-interim [] synonym: "iTRAQ114nterm" EXACT OMSSA-label [] synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] xref: DiffAvg: "144.11" xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" xref: DiffMono: "144.105919" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01487 name: iTRAQ4plex-114 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:168, UniMod:532#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 114" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ114" RELATED UniMod-interim [] synonym: "iTRAQ114K" EXACT OMSSA-label [] synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] xref: DiffAvg: "144.11" xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" xref: DiffMono: "144.105919" xref: Formula: "(12)C 11 (13)C 2 H 24 N 4 (16)O 1 (18)O 1" xref: MassAvg: "272.20" xref: MassMono: "272.200882" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01488 name: iTRAQ4plex-114 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:169, UniMod:532#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 114" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ114" RELATED UniMod-interim [] synonym: "iTRAQ114Y" EXACT OMSSA-label [] synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] xref: DiffAvg: "144.11" xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" xref: DiffMono: "144.105919" xref: Formula: "(12)C 14 (13)C 2 H 21 N 3 (16)O 2 (18)O 1" xref: MassAvg: "307.17" xref: MassMono: "307.169248" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01489 name: iTRAQ4plex-114 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] xref: DiffAvg: "144.11" xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" xref: DiffMono: "144.105919" xref: Formula: "(12)C 11 (13)C 2 H 19 N 5 O 1 (18)O 1" xref: MassAvg: "281.16" xref: MassMono: "281.164831" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue [Term] id: MOD:01490 name: iTRAQ4plex-114 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] xref: DiffAvg: "144.11" xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" xref: DiffMono: "144.105919" xref: Formula: "(12)C 8 (13)C 2 H 17 N 3 O 2 (18)O 1" xref: MassAvg: "231.14" xref: MassMono: "231.137947" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01491 name: iTRAQ4plex-114 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex114" RELATED PSI-MS-label [] xref: DiffAvg: "144.11" xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1" xref: DiffMono: "144.105919" xref: Formula: "(12)C 9 (13)C 2 H 19 N 3 O 2 (18)O 1" xref: MassAvg: "245.15" xref: MassMono: "245.153598" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01492 name: iTRAQ4plex-115 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [UniMod:533] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ115" RELATED UniMod-interim [] synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" xref: DiffMono: "144.099599" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01430 ! (18)O isotope tagged reagent is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue [Term] id: MOD:01493 name: iTRAQ4plex-115 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:170, UniMod:533#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ115" RELATED UniMod-interim [] synonym: "iTRAQ115nterm" EXACT OMSSA-label [] synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" xref: DiffMono: "144.099599" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01494 name: iTRAQ4plex-115 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:171, UniMod:533#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ115" RELATED UniMod-interim [] synonym: "iTRAQ115K" EXACT OMSSA-label [] synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" xref: DiffMono: "144.099599" xref: Formula: "(12)C 12 (13)C 1 H 24 (14)N 3 (15)N 1 (16)O 1 (18)O 1" xref: MassAvg: "272.19" xref: MassMono: "272.194562" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01495 name: iTRAQ4plex-115 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:172, UniMod:533#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ115" RELATED UniMod-interim [] synonym: "iTRAQ115Y" EXACT OMSSA-label [] synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" xref: DiffMono: "144.099599" xref: Formula: "(12)C 15 (13)C 1 H 21 (14)N 2 (15)N 1 (16)O 2 (18)O 1" xref: MassAvg: "307.16" xref: MassMono: "307.162928" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01496 name: iTRAQ4plex-115 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" xref: DiffMono: "144.099599" xref: Formula: "(12)C 12 (13)C 1 H 19 (14)N 4 (15)N 1 (16)O 1 (18)O 1" xref: MassAvg: "281.16" xref: MassMono: "281.158511" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue [Term] id: MOD:01497 name: iTRAQ4plex-115 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" xref: DiffMono: "144.099599" xref: Formula: "(12)C 9 (13)C 1 H 17 N 1 (14)N 1 (15)N 1 (16)O 2 (18)O 1" xref: MassAvg: "231.13" xref: MassMono: "231.131628" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01498 name: iTRAQ4plex-115 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex115" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1" xref: DiffMono: "144.099599" xref: Formula: "(12)C 10 (13)C 1 H 19 (14)N 2 (15)N 1 (16)O 2 (18)O 1" xref: MassAvg: "245.15" xref: MassMono: "245.147278" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01499 name: iTRAQ4plex-116 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [UniMod:214] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ" RELATED UniMod-interim [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01517 ! modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue [Term] id: MOD:01500 name: iTRAQ4plex-116 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:173, UniMod:214#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ" RELATED UniMod-interim [] synonym: "iTRAQ116nterm" EXACT OMSSA-label [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01501 name: iTRAQ4plex-116 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:174, UniMod:214#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ" RELATED UniMod-interim [] synonym: "iTRAQ116K" EXACT OMSSA-label [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1" xref: MassAvg: "272.20" xref: MassMono: "272.197025" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01502 name: iTRAQ4plex-116 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:175, UniMod:214#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ" RELATED UniMod-interim [] synonym: "iTRAQ116Y" EXACT OMSSA-label [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1" xref: MassAvg: "307.17" xref: MassMono: "307.165391" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01503 name: iTRAQ4plex-116 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 10 (13)C 3 H 19 N 3 (14)N 1 (15)N 1 (16)O 2" xref: MassAvg: "281.16" xref: MassMono: "281.160974" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue [Term] id: MOD:01504 name: iTRAQ4plex-116 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3" xref: MassAvg: "231.13" xref: MassMono: "231.134091" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01505 name: iTRAQ4plex-116 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3" xref: MassAvg: "245.15" xref: MassMono: "245.149741" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01506 name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [UniMod:214, UniMod:889] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] synonym: "iTRAQ" RELATED UniMod-interim [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] synonym: "mTRAQ heavy" RELATED UniMod-description [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01517 ! modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue is_a: MOD:01863 ! mTRAQ reporter+balance reagent acylated residue [Term] id: MOD:01507 name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:176, OMSSA:211, UniMod:214#N-term, UniMod:889N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] synonym: "iTRAQ" RELATED UniMod-interim [] synonym: "iTRAQ117nterm" EXACT OMSSA-label [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] synonym: "mTRAQ heavy" RELATED UniMod-description [] synonym: "mTRAQ heavy on nterm" EXACT OMSSA-label [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01508 name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:177, OMSSA:212, UniMod:214#K, UniMod:889#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] synonym: "iTRAQ" RELATED UniMod-interim [] synonym: "iTRAQ117K" EXACT OMSSA-label [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] synonym: "mTRAQ heavy" RELATED UniMod-description [] synonym: "mTRAQ heavy on K" EXACT OMSSA-label [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1" xref: MassAvg: "272.20" xref: MassMono: "272.197025" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01509 name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:178, OMSSA:213, UniMod:214#Y, UniMod:889#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] synonym: "iTRAQ" RELATED UniMod-interim [] synonym: "iTRAQ117Y" EXACT OMSSA-label [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] synonym: "mTRAQ heavy" RELATED UniMod-description [] synonym: "mTRAQ heavy on Y" EXACT OMSSA-label [] synonym: "Representative mass and accurate mass for 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1" xref: MassAvg: "307.17" xref: MassMono: "307.165391" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01510 name: iTRAQ4plex-117 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 10 (13)C 3 H 19 (14)N 4 (15)N 1 (16)O 2" xref: MassAvg: "281.16" xref: MassMono: "281.160974" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue [Term] id: MOD:01511 name: iTRAQ4plex-117 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3" xref: MassAvg: "231.13" xref: MassMono: "231.134091" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01512 name: iTRAQ4plex-117 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "iTRAQ4plex" RELATED PSI-MS-label [] xref: DiffAvg: "144.10" xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1" xref: DiffMono: "144.102062" xref: Formula: "(12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3" xref: MassAvg: "245.15" xref: MassMono: "245.149741" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue [Term] id: MOD:01513 name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.1 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00538 ! protein modification categorized by isobaric sets [Term] id: MOD:01514 name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.01 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01513 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da [Term] id: MOD:01515 name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.000001 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da [Term] id: MOD:01516 name: modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. def: "Modifications that have monoisotopic mass differences from their respective origins of 144.099-144.106 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da [Term] id: MOD:01517 name: modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da def: "Modifications that have monoisotopic mass differences from their respective origins of 144.102062 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. [Term] id: MOD:01518 name: iTRAQ4plex reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [UniMod:214] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue is_a: MOD:01705 ! isotope tagged reagent acylated residue [Term] id: MOD:01519 name: reporter fragment def: "A distinct molecular entity produced from a protein or a protein modification as the result of a fragmentation process." [PubMed:18688235] comment: The reporter fragment is either itself a modification consisting of atoms derived from the original amino acid residues, or its detection can be taken as evidence that particular modified residues had been present. subset: PSI-MOD-slim is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01520 name: modification reporter fragment def: "A distinct molecular entity produced as the result of a fragmentation process performed on a particular modified residue." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01519 ! reporter fragment [Term] id: MOD:01521 name: iTRAQ4plex reporter fragment def: "A protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01520 ! modification reporter fragment [Term] id: MOD:01522 name: iTRAQ4plex-114 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 114 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 2" xref: MassAvg: "114.11" xref: MassMono: "114.110680" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01521 ! iTRAQ4plex reporter fragment relationship: derives_from MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue [Term] id: MOD:01523 name: iTRAQ4plex-115 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 115 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1" xref: MassAvg: "115.11" xref: MassMono: "115.107715" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01521 ! iTRAQ4plex reporter fragment relationship: derives_from MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue [Term] id: MOD:01524 name: iTRAQ4plex-116 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 116 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1" xref: MassAvg: "116.11" xref: MassMono: "116.111069" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01521 ! iTRAQ4plex reporter fragment relationship: derives_from MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue [Term] id: MOD:01525 name: iTRAQ4plex-117, mTRAQ heavy, reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 117 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1" xref: MassAvg: "117.11" xref: MassMono: "117.114424" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01521 ! iTRAQ4plex reporter fragment is_a: MOD:01870 ! mTRAQ reporter fragment relationship: derives_from MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue [Term] id: MOD:01526 name: iTRAQ8plex reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [UniMod:730] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue is_a: MOD:01705 ! isotope tagged reagent acylated residue [Term] id: MOD:01527 name: residue reporter fragment def: "A distinct molecular entity produced from a particular amino acid residue as the result of a fragmentation process." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01519 ! reporter fragment [Term] id: MOD:01528 name: iTRAQ8plex-113 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [UniMod:730] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da [Term] id: MOD:01529 name: iTRAQ8plex-113 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [UniMod:730#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01530 name: iTRAQ8plex-113 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [UniMod:730#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4" xref: MassAvg: "432.30" xref: MassMono: "432.300322" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01531 name: iTRAQ8plex-113 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [UniMod:730#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "467.27" xref: MassMono: "467.268688" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01532 name: iTRAQ8plex-113 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4" xref: MassAvg: "441.26" xref: MassMono: "441.264271" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01533 name: iTRAQ8plex-113 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "391.24" xref: MassMono: "391.237388" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01534 name: iTRAQ8plex-113 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "405.25" xref: MassMono: "405.253038" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01535 name: iTRAQ8plex-114 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [UniMod:730] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da [Term] id: MOD:01536 name: iTRAQ8plex-114 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [UniMod:730#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01537 name: iTRAQ8plex-114 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [UniMod:730#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4" xref: MassAvg: "432.30" xref: MassMono: "432.300322" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01538 name: iTRAQ8plex-114 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [UniMod:730#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "467.27" xref: MassMono: "467.268688" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01539 name: iTRAQ8plex-114 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4" xref: MassAvg: "441.26" xref: MassMono: "441.264271" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01540 name: iTRAQ8plex-114 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "391.24" xref: MassMono: "391.237388" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01541 name: iTRAQ8plex-114 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "405.25" xref: MassMono: "405.253038" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01542 name: iTRAQ8plex-115 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [UniMod:731] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da [Term] id: MOD:01543 name: iTRAQ8plex-115 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [UniMod:731#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01544 name: iTRAQ8plex-115 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [UniMod:731#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4" xref: MassAvg: "432.29" xref: MassMono: "432.294002" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01545 name: iTRAQ8plex-115 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [UniMod:731#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "467.26" xref: MassMono: "467.262368" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01546 name: iTRAQ8plex-115 reporter+balance reagent N'-derivatized histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4" xref: MassAvg: "441.26" xref: MassMono: "441.257951" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01547 name: iTRAQ8plex-115 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "391.23" xref: MassMono: "391.231068" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01548 name: iTRAQ8plex-115 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "405.25" xref: MassMono: "405.246718" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01549 name: iTRAQ8plex-116 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [UniMod:730] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da [Term] id: MOD:01550 name: iTRAQ8plex-116 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [UniMod:730#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01551 name: iTRAQ8plex-116 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [UniMod:730#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4" xref: MassAvg: "432.30" xref: MassMono: "432.300322" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01552 name: iTRAQ8plex-116 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [UniMod:730#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "467.27" xref: MassMono: "467.268688" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01553 name: iTRAQ8plex-116 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4" xref: MassAvg: "441.26" xref: MassMono: "441.264271" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01554 name: iTRAQ8plex-116 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "391.24" xref: MassMono: "391.237388" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01555 name: iTRAQ8plex-116 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "405.25" xref: MassMono: "405.253038" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01556 name: iTRAQ8plex-117 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [UniMod:730] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da [Term] id: MOD:01557 name: iTRAQ8plex-117 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [UniMod:730#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01558 name: iTRAQ8plex-117 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [UniMod:730#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4" xref: MassAvg: "432.30" xref: MassMono: "432.300322" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01559 name: iTRAQ8plex-117 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [UniMod:730#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex" RELATED UniMod-interim [] synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED UniMod-alternate [] synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED UniMod-description [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "467.27" xref: MassMono: "467.268688" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01560 name: iTRAQ8plex-117 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4" xref: MassAvg: "441.26" xref: MassMono: "441.264271" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01561 name: iTRAQ8plex-117 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "391.24" xref: MassMono: "391.237388" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01562 name: iTRAQ8plex-117 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.21" xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3" xref: DiffMono: "304.205359" xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5" xref: MassAvg: "405.25" xref: MassMono: "405.253038" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01563 name: iTRAQ8plex-118 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [UniMod:731] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da [Term] id: MOD:01564 name: iTRAQ8plex-118 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [UniMod:731#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01565 name: iTRAQ8plex-118 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [UniMod:731#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4" xref: MassAvg: "432.29" xref: MassMono: "432.294002" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01566 name: iTRAQ8plex-118 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [UniMod:731#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "467.26" xref: MassMono: "467.262368" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01567 name: iTRAQ8plex-118 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4" xref: MassAvg: "441.26" xref: MassMono: "441.257951" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01568 name: iTRAQ8plex-118 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "391.23" xref: MassMono: "391.231068" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01569 name: iTRAQ8plex-118 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "405.25" xref: MassMono: "405.246718" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01570 name: iTRAQ8plex-119 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [UniMod:731] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da [Term] id: MOD:01571 name: iTRAQ8plex-119 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [UniMod:731#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01572 name: iTRAQ8plex-119 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [UniMod:731#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4" xref: MassAvg: "432.29" xref: MassMono: "432.294002" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01573 name: iTRAQ8plex-119 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [UniMod:731#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "467.26" xref: MassMono: "467.262368" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01574 name: iTRAQ8plex-119 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4" xref: MassAvg: "441.26" xref: MassMono: "441.257951" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01575 name: iTRAQ8plex-119 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "391.23" xref: MassMono: "391.231068" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01576 name: iTRAQ8plex-119 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "405.25" xref: MassMono: "405.246718" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01577 name: iTRAQ8plex-121 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [UniMod:731] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da [Term] id: MOD:01578 name: iTRAQ8plex-121 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [UniMod:731#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal [Term] id: MOD:01579 name: iTRAQ8plex-121 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [UniMod:731#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4" xref: MassAvg: "432.29" xref: MassMono: "432.294002" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01580 name: iTRAQ8plex-121 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [UniMod:731#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Accurate mass for 115, 118, 119 & 121" RELATED UniMod-description [] synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED UniMod-alternate [] synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED UniMod-interim [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "467.26" xref: MassMono: "467.262368" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01581 name: iTRAQ8plex-121 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4" xref: MassAvg: "441.26" xref: MassMono: "441.257951" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01582 name: iTRAQ8plex-121 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "391.23" xref: MassMono: "391.231068" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01583 name: iTRAQ8plex-121 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.20" xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3" xref: DiffMono: "304.199039" xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5" xref: MassAvg: "405.25" xref: MassMono: "405.246718" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue [Term] id: MOD:01584 name: modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da def: "Modifications that have monoisotopic mass differences from their respective origins of 304.199039 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da is_a: MOD:01592 ! modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da [Term] id: MOD:01585 name: O-glycyl-L-serine def: "A protein modification that effectively crosslinks an L-serine residue and a glycine residue by an ester bond to form O-glycyl-L-serine." [PubMed:17502423, RESID:AA0495] comment: Cross-link 2. synonym: "(2S)-2-amino-3-[(aminoacetyl)oxy]propanoic acid" EXACT RESID-systematic [] synonym: "O-(glycyl)-L-serine" EXACT RESID-name [] synonym: "O3-(aminoacetyl)serine" EXACT RESID-alternate [] synonym: "serine glycinate ester" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 5 H 7 N 2 O 3" xref: MassAvg: "143.12" xref: MassMono: "143.045667" xref: Origin: "G, S" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00885 ! ester crosslinked residues is_a: MOD:00908 ! modified glycine residue is_a: MOD:00916 ! modified L-serine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:01586 name: O-glycyl-L-threonine def: "A protein modification that effectively crosslinks an L-threonine residue and a glycine residue by an ester bond to form O-glycyl-L-threonine." [PubMed:17502423, RESID:AA0496] comment: Cross-link 2. synonym: "(2S,3R)-2-amino-3-[(aminoacetyl)oxy]butanoic acid" EXACT RESID-systematic [] synonym: "O-(glycyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(2-aminoacetyl)threonine" EXACT RESID-alternate [] synonym: "threonine glycinate ester" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 9 N 2 O 3" xref: MassAvg: "157.15" xref: MassMono: "157.061317" xref: Origin: "G, T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00885 ! ester crosslinked residues is_a: MOD:00908 ! modified glycine residue is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:01587 name: O-(2-aminoethylphosphoryl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(2-aminoethylphosphoryl)-L-serine." [PubMed:15249686, PubMed:16825186, PubMed:16949362, RESID:AA0497] synonym: "(2S)-2-amino-3-([(2-aminoethoxy)(hydroxy)phosphoryl]oxy)propanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES O-(2-aminoethylphosphoryl)serine" EXACT UniProt-feature [] synonym: "O-(2-aminoethylphosphoryl)-L-serine" EXACT RESID-name [] synonym: "O3-(2-aminoethylphosphoryl)-L-serine" EXACT RESID-alternate [] synonym: "O3-(phosphoethanolamine)-L-serine" EXACT RESID-alternate [] synonym: "serine ethanolamine phosphate" EXACT RESID-alternate [] synonym: "serine ethanolamine phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "123.05" xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1" xref: DiffMono: "123.008530" xref: Formula: "C 5 H 11 N 2 O 5 P 1" xref: MassAvg: "210.13" xref: MassMono: "210.040558" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01588 name: O-cholinephosphoryl-L-serine def: "A protein modification that effectively converts an L-serine residue to O-cholinephosphoryl-L-serine." [PubMed:15249686, PubMed:16825186, PubMed:16949362, RESID:AA0498] synonym: "2-[([(2S)-2-amino-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanaminium" EXACT RESID-systematic [] synonym: "2-[([(2S)-2-azanyl-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanazanium" EXACT RESID-alternate [] synonym: "MOD_RES O-(2-cholinephosphoryl)serine" EXACT UniProt-feature [] synonym: "O-cholinephosphoryl-L-serine" EXACT RESID-name [] synonym: "O3-[(2-[trimethylammonio]ethyl)phosphoryl]-L-serine" EXACT RESID-alternate [] synonym: "O3-phosphocholine-L-serine" EXACT RESID-alternate [] synonym: "serine choline phosphate" EXACT RESID-alternate [] synonym: "serine choline phosphodiester" EXACT RESID-alternate [] xref: DiffAvg: "166.14" xref: DiffFormula: "C 5 H 13 N 1 O 3 P 1" xref: DiffMono: "166.062756" xref: FormalCharge: "1+" xref: Formula: "C 8 H 18 N 2 O 5 P 1" xref: MassAvg: "253.21" xref: MassMono: "253.094785" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01589 name: O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine." [PubMed:15249686, PubMed:16949362, RESID:AA0499] synonym: "(2S)-2-amino-3-[(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic [] synonym: "DADDGlc" EXACT RESID-alternate [] synonym: "O-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] synonym: "O-(2,4-diacetamido-2,4-dideoxy-D-glucosyl)-L-serine" EXACT RESID-name [] synonym: "O-[2,4-bis(acetylamino)]glucosyl-L-serine" EXACT RESID-alternate [] synonym: "O-seryl-beta-2,4-bis(acetylamino)glucoside" EXACT RESID-alternate [] synonym: "O3-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] xref: DiffAvg: "244.25" xref: DiffFormula: "C 10 H 16 N 2 O 5" xref: DiffMono: "244.105922" xref: Formula: "C 13 H 21 N 3 O 7" xref: MassAvg: "331.33" xref: MassMono: "331.137950" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine [Term] id: MOD:01590 name: 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan." [ChEBI:52950, PubMed:18323630, RESID:AA0500] synonym: "(2S,3aR,8aS)-3a-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid" EXACT RESID-systematic [] synonym: "3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan" EXACT RESID-name [] synonym: "LIPID 3'-farnesyl-2',N2-cyclotryptophan" EXACT UniProt-feature [] xref: DiffAvg: "204.36" xref: DiffFormula: "C 15 H 24 N 0 O 0" xref: DiffMono: "204.187801" xref: Formula: "C 26 H 34 N 2 O 1" xref: MassAvg: "390.57" xref: MassMono: "390.267114" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00437 ! farnesylated residue is_a: MOD:00601 ! cyclized residue is_a: MOD:01115 ! isoprenylated tryptophan [Term] id: MOD:01591 name: modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da def: "Modifications that have monoisotopic mass differences from their respective origins of 304.205359 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da is_a: MOD:01592 ! modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da [Term] id: MOD:01592 name: modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da def: "Modifications that have monoisotopic mass differences from their respective origins of 304.199-304.206 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da [Term] id: MOD:01593 name: iTRAQ8plex reporter fragment def: "A protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] is_a: MOD:01520 ! modification reporter fragment [Term] id: MOD:01594 name: iTRAQ8plex-113 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-113 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 6 H 13 (14)N 2" xref: MassAvg: "113.11" xref: MassMono: "113.107325" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01593 ! iTRAQ8plex reporter fragment relationship: derives_from MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue [Term] id: MOD:01595 name: iTRAQ8plex-114 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-114 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 2" xref: MassAvg: "114.11" xref: MassMono: "114.110680" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01593 ! iTRAQ8plex reporter fragment relationship: derives_from MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue [Term] id: MOD:01596 name: iTRAQ8plex-115 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-115 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1" xref: MassAvg: "115.11" xref: MassMono: "115.107715" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01593 ! iTRAQ8plex reporter fragment relationship: derives_from MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue [Term] id: MOD:01597 name: iTRAQ8plex-116 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-116 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1" xref: MassAvg: "116.11" xref: MassMono: "116.111069" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01593 ! iTRAQ8plex reporter fragment relationship: derives_from MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue [Term] id: MOD:01598 name: iTRAQ8plex-117 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-117 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1" xref: MassAvg: "117.11" xref: MassMono: "117.114424" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01593 ! iTRAQ8plex reporter fragment relationship: derives_from MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue [Term] id: MOD:01599 name: iTRAQ8plex-118 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-118 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 3 (13)C 3 H 13 (15)N 2" xref: MassAvg: "118.11" xref: MassMono: "118.111459" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01593 ! iTRAQ8plex reporter fragment relationship: derives_from MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue [Term] id: MOD:01600 name: iTRAQ8plex-119 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-119 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 2 (13)C 4 H 13 (15)N 2" xref: MassAvg: "119.11" xref: MassMono: "119.114814" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01593 ! iTRAQ8plex reporter fragment relationship: derives_from MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue [Term] id: MOD:01601 name: iTRAQ8plex-121 reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-121 reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(13)C 6 H 13 (15)N 2" xref: MassAvg: "121.12" xref: MassMono: "121.121524" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01593 ! iTRAQ8plex reporter fragment relationship: derives_from MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue [Term] id: MOD:01602 name: S-(L-lysyl)-L-methionine sulfilimine def: "A protein modification that effectively converts an L-lysine residue, and an L-methionine residue to S-(L-lysyl)-L-methionine sulfilimine." [PubMed:12011424, PubMed:15951440, PubMed:19729652, RESID:AA0501] comment: Cross-link 2. synonym: "(2S)-2-amino-6-([(E)-[(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "(E)-N6-([(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene)-L-lysine" EXACT RESID-alternate [] synonym: "S-(L-lysyl)-L-methionine sulfilimine" EXACT RESID-name [] synonym: "S-lysyl-methionine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 11 H 19 N 3 O 2 S 1" xref: MassAvg: "257.35" xref: MassMono: "257.119798" xref: Origin: "K, M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:01603 name: 2x(15)N labeled L-lysine def: "A protein modification that effectively converts an L-lysine residue to 2x(15)N labeled L-lysine." [PubMed:18688235, URL:http\://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=609021|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC&lang=en_US0.000000E+000] subset: PSI-MOD-slim xref: DiffAvg: "1.99" xref: DiffFormula: "(14)N -2 (15)N 2" xref: DiffMono: "1.994070" xref: Formula: "C 6 H 12 (15)N 2 O 1" xref: MassAvg: "130.09" xref: MassMono: "130.089033" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00843 ! (15)N labeled residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01604 name: 4x(15)N labeled L-arginine def: "A protein modification that effectively converts an L-arginine residue to 4x(15)N labeled L-arginine." [PubMed:18688235, URL:http\://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=600113|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC&lang=en_US0.000000E+000] subset: PSI-MOD-slim xref: DiffAvg: "3.99" xref: DiffFormula: "(14)N -4 (15)N 4" xref: DiffMono: "3.988140" xref: Formula: "C 6 H 12 (15)N 4 O 1" xref: MassAvg: "160.09" xref: MassMono: "160.089251" xref: Origin: "R" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00843 ! (15)N labeled residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:01605 name: 5-glutamyl 2-aminoadipic acid def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic acid." [PubMed:19620981, RESID:AA0502] synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanedioic acid" EXACT RESID-systematic [] synonym: "5-glutamyl 2-aminoadipic acid" EXACT RESID-name [] synonym: "MOD_RES 5-glutamyl 2-aminoadipic acid" EXACT UniProt-feature [] synonym: "N2-(gamma-glutamyl)-2-aminoadipic acid" EXACT RESID-alternate [] synonym: "N2-(isoglutamyl)-2-aminoadipic acid" EXACT RESID-alternate [] xref: DiffAvg: "143.14" xref: DiffFormula: "C 6 H 9 N 1 O 3" xref: DiffMono: "143.058243" xref: Formula: "C 11 H 16 N 2 O 6" xref: MassAvg: "272.26" xref: MassMono: "272.100836" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00674 ! amidated residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01606 name: 5-glutamyl 2-aminoadipic 6-phosphoric anhydride def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic 6-phosphoric anhydride." [PubMed:19620981, RESID:AA0503] synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxo-6-(phosphonooxy)hexanoic acid" EXACT RESID-systematic [] synonym: "5-glutamyl 2-aminoadipic 6-phosphoric anhydride" EXACT RESID-name [] xref: DiffAvg: "223.12" xref: DiffFormula: "C 6 H 10 N 1 O 6 P 1" xref: DiffMono: "223.024574" xref: Formula: "C 11 H 17 N 2 O 9 P 1" xref: MassAvg: "352.24" xref: MassMono: "352.067167" xref: Origin: "E" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00674 ! amidated residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01607 name: 5-glutamyl allysine def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl allysine." [PubMed:19620981, RESID:AA0504] synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxohexanoic acid" EXACT RESID-systematic [] synonym: "2-(5-glutamyl)amino-6-oxohexanoic acid" EXACT RESID-alternate [] synonym: "5-glutamyl allysine" EXACT RESID-name [] synonym: "alpha-(gamma-glutamyl)allysine" EXACT RESID-alternate [] synonym: "N2-(gamma-glutamyl)allysine" EXACT RESID-alternate [] synonym: "N2-(isoglutamyl)allysine" EXACT RESID-alternate [] xref: DiffAvg: "127.14" xref: DiffFormula: "C 6 H 9 N 1 O 2" xref: DiffMono: "127.063329" xref: Formula: "C 11 H 16 N 2 O 5" xref: MassAvg: "256.26" xref: MassMono: "256.105922" xref: Origin: "E" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00674 ! amidated residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01608 name: N2-(L-isoglutamyl)-L-lysine def: "A protein modification that effectively converts an L-glutamic acid residue to N2-(L-isoglutamyl)-L-lysine. This is not an isopeptide cross-link." [PubMed:19620981, RESID:AA0505] synonym: "(2S)-6-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "5-glutamyl N2-lysine" EXACT RESID-alternate [] synonym: "alpha-(gamma-glutamyl)lysine" EXACT RESID-alternate [] synonym: "gamma-glutamyl N2-lysine" EXACT RESID-alternate [] synonym: "MOD_RES 5-glutamyl N2-lysine" EXACT UniProt-feature [] synonym: "N2-(gamma-glutamyl)lysine" EXACT RESID-alternate [] synonym: "N2-(L-isoglutamyl)-L-lysine" EXACT RESID-name [] xref: DiffAvg: "128.18" xref: DiffFormula: "C 6 H 12 N 2 O 1" xref: DiffMono: "128.094963" xref: Formula: "C 11 H 19 N 3 O 4" xref: MassAvg: "257.29" xref: MassMono: "257.137556" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01609 name: 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan." [PubMed:19584055, RESID:AA0506] synonym: "(2S)-2-amino-3-[7-hydroxy-2-(alpha-D-mannopyranosyl)-1H-indol-3-yl]propanoic acid" EXACT RESID-systematic [] synonym: "7'-hydroxy-2'-alpha-mannosyl-L-tryptophan" EXACT RESID-name [] synonym: "MOD_RES 7'-hydroxytryptophan" EXACT UniProt-feature [] xref: DiffAvg: "178.14" xref: DiffFormula: "C 6 H 10 N 0 O 6" xref: DiffMono: "178.047738" xref: Formula: "C 17 H 20 N 2 O 7" xref: MassAvg: "364.35" xref: MassMono: "364.127051" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00918 ! modified L-tryptophan residue relationship: has_functional_parent MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan relationship: has_functional_parent MOD:01664 ! 7'-hydroxy-L-tryptophan [Term] id: MOD:01610 name: L-threonine methyl ester def: "A protein modification that effectively converts an L-threonine residue to L-threonine methyl ester." [PubMed:19745839, RESID:AA0507] synonym: "L-threonine methyl ester" EXACT RESID-name [] synonym: "methyl (2S,3R)-2-amino-3-hydroxybutanoate" EXACT RESID-systematic [] synonym: "methyl L-threoninate" EXACT RESID-alternate [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 5 H 10 N 1 O 3" xref: MassAvg: "132.14" xref: MassMono: "132.066068" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01689 ! alpha-carboxyl methylated residue is_a: MOD:01803 ! O-methylated threonine [Term] id: MOD:01611 name: 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN def: "A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN." [PubMed:17935335, RESID:AA0508] comment: Cross-link 2. subset: PSI-MOD-slim synonym: "6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-trihydrogen phosphate" EXACT RESID-systematic [] synonym: "6-(S-cysteinyl)-8alpha-(N(delta)-histidyl)-FMN" EXACT RESID-alternate [] synonym: "6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FMN" EXACT RESID-alternate [] synonym: "6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FMN" EXACT RESID-alternate [] synonym: "6-(S-cysteinyl)-8alpha-(pros-histidyl)-FMN" EXACT RESID-alternate [] synonym: "6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FMN" EXACT RESID-name [] synonym: "BINDING FMN (covalent; via 2 links)" EXACT UniProt-feature [] synonym: "BINDING FMN (covalent; via 2 links, pros nitrogen)" EXACT UniProt-feature [] xref: DiffAvg: "452.32" xref: DiffFormula: "C 17 H 17 N 4 O 9 P 1 S 0" xref: DiffMono: "452.073315" xref: Formula: "C 26 H 29 N 8 O 11 P 1 S 1" xref: MassAvg: "692.60" xref: MassMono: "692.141411" xref: Origin: "C, H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00896 ! FMN modified residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01621 ! flavin crosslinked residues [Term] id: MOD:01612 name: 3'-iodo-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 3'-iodo-L-tyrosine." [ChEBI:27847, PubMed:8995307, RESID:AA0509] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid" EXACT RESID-systematic [] synonym: "3'-iodo-L-tyrosine" EXACT RESID-name [] synonym: "3-iodo-L-tyrosine" EXACT RESID-alternate [] synonym: "3-iodotyrosine" EXACT RESID-alternate [] synonym: "4-hydroxy-3-iodo-phenylalanine" EXACT RESID-alternate [] synonym: "MIT" EXACT RESID-alternate [] synonym: "MOD_RES Iodotyrosine" EXACT UniProt-feature [] xref: DiffAvg: "125.90" xref: DiffFormula: "C 0 H -1 I 1 N 0 O 0" xref: DiffMono: "125.896648" xref: Formula: "C 9 H 8 I 1 N 1 O 2" xref: MassAvg: "289.07" xref: MassMono: "288.959976" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01228 ! monoiodinated tyrosine [Term] id: MOD:01613 name: 3',5'-diiodo-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-diiodo-L-tyrosine." [ChEBI:15768, PubMed:8995307, RESID:AA0510] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid" EXACT RESID-systematic [] synonym: "3',5'-diiodo-L-tyrosine" EXACT RESID-name [] synonym: "3,5-diiodo-L-tyrosine" EXACT RESID-alternate [] synonym: "3,5-diiodotyrosine" EXACT RESID-alternate [] synonym: "DIT" EXACT RESID-alternate [] synonym: "iodogorgoic acid" EXACT RESID-alternate [] synonym: "MOD_RES Diiodotyrosine" EXACT UniProt-feature [] xref: DiffAvg: "251.79" xref: DiffFormula: "C 0 H -2 I 2 N 0 O 0" xref: DiffMono: "251.793295" xref: Formula: "C 9 H 7 I 2 N 1 O 2" xref: MassAvg: "414.97" xref: MassMono: "414.856624" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01140 ! diiodinated tyrosine [Term] id: MOD:01614 name: glycyl phospho-5'-adenosine def: "A protein modification that effectively converts a glycine residue to glycyl phospho-5'-adenosine." [PubMed:16388576, PubMed:9632726, RESID:AA0511] synonym: "(2-aminoacetyl)oxy-([(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy)phosphinic acid" EXACT RESID-alternate [] synonym: "([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl)-2-aminoethanoate" EXACT RESID-alternate [] synonym: "5'-adenylic-glyinate" EXACT RESID-alternate [] synonym: "aminoacetyl [5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen phosphate" EXACT RESID-systematic [] synonym: "glycine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate [] synonym: "glycyl 5'-adenylate" EXACT RESID-alternate [] synonym: "glycyl adenosine-5'-phosphate" EXACT RESID-alternate [] synonym: "glycyl phospho-5'-adenosine" EXACT RESID-name [] synonym: "glycyladenylate" EXACT RESID-alternate [] synonym: "MOD_RES Glycyl adenylate" EXACT UniProt-feature [] xref: DiffAvg: "329.21" xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1" xref: DiffMono: "329.052520" xref: Formula: "C 12 H 16 N 6 O 8 P 1" xref: MassAvg: "403.27" xref: MassMono: "403.076723" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01165 ! adenylated residue [Term] id: MOD:01615 name: glycyl cysteine dithioester def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a dithioester bond to form glycyl cysteine dithioester." [PubMed:11438688, PubMed:16388576, RESID:AA0512] comment: Cross-link 2. synonym: "(2R)-2-amino-3-[(aminoacetyl)disulfanyl]propanoic acid" EXACT RESID-systematic [] synonym: "2-(glycyldithio)alanine" EXACT RESID-alternate [] synonym: "glycyl cysteine dithioester" EXACT RESID-name [] synonym: "S-glycyl cysteine persulfide" EXACT RESID-alternate [] synonym: "S-glycyl thiocysteine" EXACT RESID-alternate [] synonym: "thioglycine cysteine disulfide" EXACT RESID-alternate [] xref: DiffAvg: "14.05" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 1" xref: DiffMono: "13.961506" xref: Formula: "C 5 H 7 N 2 O 2 S 2" xref: MassAvg: "191.24" xref: MassMono: "190.994894" xref: Origin: "C, G" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00395 ! thioester crosslinked residues is_a: MOD:00908 ! modified glycine residue is_a: MOD:00954 ! crosslinked residues with loss of water [Term] id: MOD:01616 name: trithiocystine def: "A protein modification that effectively cross-links two L-cysteine residues and adds three sulfur atoms to form trithiocystine." [PubMed:19438211, RESID:AA0513] comment: Cross-link 2. synonym: "(2R,2'R)-3,3'-pentasulfane-1,5-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "3,3'-pentathiobisalanine" EXACT RESID-alternate [] synonym: "bis(2-amino-2-carboxyethyl)pentasulfide" EXACT RESID-alternate [] synonym: "trithiocystine" EXACT RESID-name [] xref: DiffAvg: "94.16" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 3" xref: DiffMono: "93.900563" xref: Formula: "C 6 H 8 N 2 O 2 S 5" xref: MassAvg: "300.44" xref: MassMono: "299.918933" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01620 ! polysulfide crosslinked residues [Term] id: MOD:01617 name: O-(6-phosphomannosyl)-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-(6-phosphomannosyl)-L-threonine." [PubMed:20044576, RESID:AA0514] synonym: "(2S,3R)-2-amino-3-[6-phosphonooxy-alpha-D-mannopyranosyloxy]butanoic acid" EXACT RESID-systematic [] synonym: "O-(6-phosphomannosyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(6-phosphomannosyl)threonine" EXACT RESID-alternate [] xref: DiffAvg: "242.12" xref: DiffFormula: "C 6 H 11 N 0 O 8 P 1" xref: DiffMono: "242.019154" xref: Formula: "C 10 H 18 N 1 O 10 P 1" xref: MassAvg: "343.22" xref: MassMono: "343.066832" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00005 ! O-glycosyl-L-threonine is_a: MOD:00595 ! mannosylated residue [Term] id: MOD:01618 name: L-alanyl-L-isoaspartyl cyclopeptide def: "A protein modification that effectively converts an L-alaine residue and an L-asparagine residue to L-alanyl-L-isoaspartyl cyclopeptide." [PubMed:19928958, PubMed:3207697, RESID:AA0515] comment: Cross-link 2. synonym: "(2S,5S)-2-methyl-3,7-dioxo-1,4-diazepane-5-carboxylic acid" EXACT RESID-systematic [] synonym: "1,4.2-anhydro(L-alanyl-L-aspartic acid)" EXACT RESID-alternate [] synonym: "CROSSLNK Alanine isoaspartyl cyclopeptide (Ala-Asn)" EXACT UniProt-feature [] synonym: "L-alanyl-L-isoaspartyl cyclopeptide" EXACT RESID-name [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 7 H 9 N 2 O 3" xref: MassAvg: "169.16" xref: MassMono: "169.061317" xref: Origin: "A, N" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00688 ! isopeptide crosslinked residues is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:00946 ! crosslinked residues with loss of ammonia [Term] id: MOD:01619 name: multisulfide crosslinked residues def: "A protein modification that crosslinks two cysteine residues by formation of a chain of two or more bonded sulfur atoms." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00033 ! crosslinked residues is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01620 name: polysulfide crosslinked residues def: "A protein modification that crosslinks two cysteine residues by formation of a chain of three or more bonded sulfur atoms." [PubMed:18688235] is_a: MOD:00860 ! sulfur containing modified residue is_a: MOD:01619 ! multisulfide crosslinked residues [Term] id: MOD:01621 name: flavin crosslinked residues def: "A protein modification that crosslinks two or more amino acid residues by forming an adduct with a compound containing a flavin group." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00033 ! crosslinked residues is_a: MOD:00697 ! flavin modified residue [Term] id: MOD:01622 name: monohydroxylated tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to one of several monohydroxylated tryptophan residues, including 3-hydroxy-L-tryptophan and 7'-hydroxy-L-tryptophan." [OMSSA:90, UniMod:35#W] synonym: "Oxidation" RELATED PSI-MS-label [] synonym: "oxyw" EXACT OMSSA-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 11 H 10 N 2 O 2" xref: MassAvg: "202.21" xref: MassMono: "202.074228" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01623 name: 1-thioglycine (C-terminal) def: "A protein modification that effectively converts a glycine residue to a C-terminal 1-thioglycine." [PubMed:11463785, PubMed:19145231, PubMed:9367957, RESID:AA0265#var] subset: PSI-MOD-slim xref: DiffAvg: "16.06" xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1" xref: DiffMono: "15.977156" xref: Formula: "C 2 H 3 N 1 S 1" xref: MassAvg: "73.11" xref: MassMono: "72.998620" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01625 ! 1-thioglycine [Term] id: MOD:01624 name: (2-aminosuccinimidyl)acetic acid (Asn) def: "A protein modification that crosslinks an asparagine and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the release of ammonia." [PubMed:10801322, PubMed:2015294, RESID:AA0441#ASN] comment: Cross-link 2. subset: PSI-MOD-slim synonym: "(2-aminosuccinimidyl)acetic acid" EXACT RESID-name [] synonym: "(3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid" EXACT RESID-alternate [] synonym: "[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid" EXACT RESID-systematic [] synonym: "anhydroaspartyl glycine" EXACT RESID-alternate [] synonym: "aspartimide glycine" EXACT RESID-alternate [] synonym: "CROSSLNK (2-aminosuccinimidyl)acetic acid (Asn-Gly)" EXACT UniProt-feature [] synonym: "N-(2-aminosuccinyl)glycine" EXACT RESID-alternate [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 6 H 6 N 2 O 3" xref: MassAvg: "154.13" xref: MassMono: "154.037842" xref: Origin: "G, N" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:00946 ! crosslinked residues with loss of ammonia is_a: MOD:01628 ! (2-aminosuccinimidyl)acetic acid [Term] id: MOD:01625 name: 1-thioglycine def: "A protein modification that effectively converts a glycine residue to 1-thioglycine." [PubMed:11463785, PubMed:9367957, RESID:AA0265] comment: This modification occurs naturally in two forms. At an interior peptide location (MOD:00270) it exists as aminoethanethionic acid, or aminoethanethioic O-acid. At the C-terminal (MOD:01623) it exists as aminoethanethiolic acid, or aminoethanethioic S-acid [JSG]. subset: PSI-MOD-slim synonym: "1-thioglycine" EXACT RESID-name [] synonym: "2-amino-1-sulfanylethanone" EXACT RESID-alternate [] synonym: "aminoethanethioic acid" EXACT RESID-systematic [] synonym: "aminothioacetic acid" EXACT RESID-alternate [] synonym: "Carboxy->Thiocarboxy" RELATED PSI-MS-label [] synonym: "MOD_RES 1-thioglycine" EXACT UniProt-feature [] synonym: "S(O)Gly" EXACT PSI-MOD-label [] synonym: "thiocarboxylic acid" RELATED UniMod-description [] xref: DiffAvg: "16.06" xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1" xref: DiffMono: "15.977156" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "G" xref: Source: "natural" is_a: MOD:00749 ! sulfur substitution for oxygen is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:01626 name: L-cystine def: "A protein modification that forms L-cystine by forming a disulfide bond that either cross-links two peptidyl L-cysteine residues, or modifies a peptidyl cysteine with a free cysteine." [ChEBI:16283, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025] comment: This modification occurs naturally in two forms. It exists as a disulfide cross-link of two cysteine residues (MOD:00034), or as a disulfide cross-link of a cysteine residues and a free cysteine (MOD:00765). subset: PSI-MOD-slim synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer [] synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate [] synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate [] synonym: "3,3'-dithiodialanine" EXACT RESID-alternate [] synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate [] synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate [] synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate [] synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate [] synonym: "Cys2" EXACT PSI-MOD-label [] synonym: "Cystine ((Cys)2)" EXACT DeltaMass-label [] synonym: "dicysteine" EXACT RESID-alternate [] synonym: "L-cystine" EXACT RESID-name [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "none" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01627 name: L-cysteinyl-L-selenocysteine def: "A protein modification that forms L-cysteinyl-L-selenocysteine either by the natural process of cross-linking an L-cysteine residue and an L-selenocysteine residue, or by the hypothetical process of substituting a selenium for a sulfur atom in cystine." [PubMed:12911312, PubMed:18688235] comment: Cross-link 2. subset: PSI-MOD-slim xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1" xref: MassAvg: "251.17" xref: MassMono: "251.947170" xref: Origin: "C, X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01628 name: (2-aminosuccinimidyl)acetic acid def: "A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following glycine residue." [PubMed:10801322, PubMed:18688235] comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. subset: PSI-MOD-slim xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 6 N 2 O 3" xref: MassAvg: "154.13" xref: MassMono: "154.037842" xref: Origin: "G, X" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues [Term] id: MOD:01629 name: cyclo[(prolylserin)-O-yl] cysteinate def: "A protein modification that forms cyclo[(prolylserin)-O-yl] cysteinate by the natural process of cross-linking an L-cysteine residue an L-proline residue, and an L-serine residue, or by effectively modifying a cysteine residue." [PubMed:7961166, RESID:AA0489] synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate [] synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic [] synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name [] synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 11 H 16 N 3 O 4 S 1" xref: MassAvg: "286.33" xref: MassMono: "286.086152" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01630 name: N6-(L-isoglutamyl)-L-lysine def: "A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine ." [ChEBI:21863, DeltaMass:0, PubMed:2461365, PubMed:5637041, PubMed:5656070, PubMed:8598899, RESID:AA0124] comment: Cross-link 2. subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate [] synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate [] synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label [] synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate [] synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 11 H 17 N 3 O 3" xref: MassAvg: "239.27" xref: MassMono: "239.126991" xref: Origin: "K, X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00688 ! isopeptide crosslinked residues is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01631 name: L-alanine removal def: "A protein modification that effectively removes or replaces an L-alanine." [PubMed:18688235] comment: This represents the loss or replacement of an L-alanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-71.08" xref: DiffFormula: "C -3 H -5 N -1 O -1" xref: DiffMono: "-71.037114" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01632 name: L-arginine removal def: "A protein modification that effectively removes or replaces an L-arginine." [PubMed:18688235] comment: This represents the loss or replacement of an L-arginine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-156.19" xref: DiffFormula: "C -6 H -12 N -4 O -1" xref: DiffMono: "-156.101111" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01633 name: L-asparagine removal def: "A protein modification that effectively removes or replaces an L-asparagine." [PubMed:18688235] comment: This represents the loss or replacement of an L-asparagine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-114.10" xref: DiffFormula: "C -4 H -6 N -2 O -2" xref: DiffMono: "-114.042927" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01634 name: L-aspartic acid removal def: "A protein modification that effectively removes or replaces an L-aspartic acid." [PubMed:18688235] comment: This represents the loss or replacement of an L-aspartic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-115.09" xref: DiffFormula: "C -4 H -5 N -1 O -3" xref: DiffMono: "-115.026943" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01635 name: L-cysteine removal def: "A protein modification that effectively removes or replaces an L-cysteine." [PubMed:18688235] comment: This represents the loss or replacement of an L-cysteine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-103.14" xref: DiffFormula: "C -3 H -5 N -1 O -1 S -1" xref: DiffMono: "-103.009185" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01636 name: L-glutamic acid removal def: "A protein modification that effectively removes or replaces an L-glutamic acid." [PubMed:18688235] comment: This represents the loss or replacement of an L-glutamic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-129.12" xref: DiffFormula: "C -5 H -7 N -1 O -3" xref: DiffMono: "-129.042593" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01637 name: L-glutamine removal def: "A protein modification that effectively removes or replaces an L-glutamine." [PubMed:18688235] comment: This represents the loss or replacement of an L-glutamine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-128.13" xref: DiffFormula: "C -5 H -8 N -2 O -2" xref: DiffMono: "-128.058578" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01638 name: glycine removal def: "A protein modification that effectively removes or replaces a glycine." [PubMed:18688235] comment: This represents the loss or replacement of an glycine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-57.05" xref: DiffFormula: "C -2 H -3 N -1 O -1" xref: DiffMono: "-57.021464" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01639 name: L-histidine removal def: "A protein modification that effectively removes or replaces an L-histidine." [PubMed:18688235] comment: This represents the loss or replacement of an L-histidine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-137.14" xref: DiffFormula: "C -6 H -7 N -3 O -1" xref: DiffMono: "-137.058912" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01640 name: L-isoleucine removal def: "A protein modification that effectively removes or replaces an L-isoleucine." [PubMed:18688235] comment: This represents the loss or replacement of an L-isoleucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-113.16" xref: DiffFormula: "C -6 H -11 N -1 O -1" xref: DiffMono: "-113.084064" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00910 ! modified L-isoleucine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01641 name: L-leucine removal def: "A protein modification that effectively removes or replaces an L-leucine." [PubMed:18688235] comment: This represents the loss or replacement of an L-leucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-113.16" xref: DiffFormula: "C -6 H -11 N -1 O -1" xref: DiffMono: "-113.084064" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "L" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00911 ! modified L-leucine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01642 name: L-lysine removal def: "A protein modification that effectively removes or replaces an L-lysine." [PubMed:18688235] comment: This represents the loss or replacement of an L-lysine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-128.18" xref: DiffFormula: "C -6 H -12 N -2 O -1" xref: DiffMono: "-128.094963" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01643 name: L-methionine removal def: "A protein modification that effectively removes or replaces an L-methionine." [OMSSA:9, PubMed:3327521, UniMod:765] comment: This represents the loss or replacement of an L-methionine residue in a polypeptide, including initiator methionine removal in eukaryotes. It may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution [JSG]. subset: PSI-MOD-slim synonym: "Met-loss" RELATED UniMod-interim [] synonym: "ntermmcleave" EXACT OMSSA-label [] xref: DiffAvg: "-131.19" xref: DiffFormula: "C -5 H -9 N -1 O -1 S -1" xref: DiffMono: "-131.040485" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01644 name: L-phenylalanine removal def: "A protein modification that effectively removes or replaces an L-phenylalanine." [PubMed:18688235] comment: This represents the loss or replacement of an L-phenylalanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-147.18" xref: DiffFormula: "C -9 H -9 N -1 O -1" xref: DiffMono: "-147.068414" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "F" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01645 name: L-proline removal def: "A protein modification that effectively removes or replaces an L-proline." [PubMed:18688235] comment: This represents the loss or replacement of an L-proline residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-97.12" xref: DiffFormula: "C -5 H -7 N -1 O -1" xref: DiffMono: "-97.052764" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01646 name: L-serine removal def: "A protein modification that effectively removes or replaces an L-serine." [PubMed:18688235] comment: This represents the loss or replacement of an L-serine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-87.08" xref: DiffFormula: "C -3 H -5 N -1 O -2" xref: DiffMono: "-87.032028" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01647 name: L-threonine removal def: "A protein modification that effectively removes or replaces an L-threonine." [PubMed:18688235] comment: This represents the loss or replacement of an L-threonine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-101.10" xref: DiffFormula: "C -4 H -7 N -1 O -2" xref: DiffMono: "-101.047678" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01648 name: L-tryptophan removal def: "A protein modification that effectively removes or replaces an L-tryptophan." [PubMed:18688235] comment: This represents the loss or replacement of an L-tryptophan residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-186.21" xref: DiffFormula: "C -11 H -10 N -2 O -1" xref: DiffMono: "-186.079313" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00918 ! modified L-tryptophan residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01649 name: L-tyrosine removal def: "A protein modification that effectively removes or replaces an L-tyrosine." [PubMed:18688235] comment: This represents the loss or replacement of an L-tyrosine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-163.18" xref: DiffFormula: "C -9 H -9 N -1 O -2" xref: DiffMono: "-163.063329" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01650 name: L-valine removal def: "A protein modification that effectively removes or replaces an L-valine." [PubMed:18688235] comment: This represents the loss or replacement of an L-valine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: DiffAvg: "-99.13" xref: DiffFormula: "C -5 H -9 N -1 O -1" xref: DiffMono: "-99.068414" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00920 ! modified L-valine residue is_a: MOD:01651 ! natural, standard, encoded residue removal [Term] id: MOD:01651 name: natural, standard, encoded residue removal def: "A protein modification that effectively removes or replaces a natural, standard, encoded residue." [PubMed:18688235] comment: This represents the loss or replacement of an encoded residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00009 ! natural residue [Term] id: MOD:01652 name: sulfonyl halide reagent derivatized residue def: "A protein modification that is produced by formation of an adduct with a sulfonyl halide compound used as a reagent." [PubMed:18688235] comment: These reagents typically react with N6-amino group of lysine residues and a free alpha-amino group of a peptide. xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01653 name: dansyl chloride derivatized residue def: "A protein modification that is produced by formation of an adduct with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride." [DeltaMass:0, UniMod:139] synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] synonym: "Dansyl" RELATED PSI-MS-label [] synonym: "Dansyl (Dns)" EXACT DeltaMass-label [] synonym: "DansylRes" EXACT PSI-MOD-label [] xref: DiffAvg: "233.29" xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" xref: DiffMono: "233.051050" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue [Term] id: MOD:01654 name: N6-Dansyl derivatized lysine def: "A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form N6-Dansyl-lysine." [UniMod:139#K] synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] synonym: "Dansyl" RELATED PSI-MS-label [] synonym: "N6DansylLys" EXACT PSI-MOD-label [] xref: DiffAvg: "233.29" xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" xref: DiffMono: "233.051050" xref: Formula: "C 18 H 23 N 3 O 3 S 1" xref: MassAvg: "361.46" xref: MassMono: "361.146013" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01653 ! dansyl chloride derivatized residue [Term] id: MOD:01655 name: alpha-amino-Dansyl derivatized residue def: "A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form an alpha-amino-Dansyl-derivatized residue." [UniMod:139#N-term] synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED UniMod-description [] synonym: "Dansyl" RELATED PSI-MS-label [] synonym: "N2DansylRes" EXACT PSI-MOD-label [] xref: DiffAvg: "233.29" xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1" xref: DiffMono: "233.051050" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01653 ! dansyl chloride derivatized residue [Term] id: MOD:01656 name: Dabsyl chloride derivatized residue def: "A protein modification that is produced by formation of an adduct with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, Dabsyl chloride." [PubMed:18688235] synonym: "4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl" EXACT PSI-MOD-alternate [] synonym: "DabsylRes" EXACT PSI-MOD-label [] xref: DiffAvg: "287.34" xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1" xref: DiffMono: "287.072848" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue [Term] id: MOD:01657 name: N6-Dabsyl derivatized lysine def: "A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form N6-Dabsyl-lysine." [PubMed:18688235] synonym: "N6-[4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl]lysine" EXACT PSI-MOD-alternate [] synonym: "N6DabsylLys" EXACT PSI-MOD-label [] xref: DiffAvg: "287.34" xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1" xref: DiffMono: "287.072848" xref: Formula: "C 20 H 25 N 5 O 3 S 1" xref: MassAvg: "415.51" xref: MassMono: "415.167811" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01656 ! Dabsyl chloride derivatized residue [Term] id: MOD:01658 name: alpha-amino-Dabsyl derivatized residue def: "A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form an alpha-amino-Dabsyl-derivatized residue." [PubMed:18688235] synonym: "N2DabsylRes" EXACT PSI-MOD-label [] xref: DiffAvg: "287.34" xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1" xref: DiffMono: "287.072848" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01656 ! Dabsyl chloride derivatized residue [Term] id: MOD:01659 name: Uniblue A derivatized residue def: "A protein modification that is produced by formation of an adduct with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A." [PubMed:18688235] comment: This reagent has a reactive sulfonyl vinyl and typically reacts with the free thiol group of cysteine residues. synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid" EXACT PSI-MOD-alternate [] synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonic acid" EXACT PSI-MOD-alternate [] synonym: "Uniblue A" EXACT PSI-MOD-alternate [] synonym: "UniblueARes" EXACT PSI-MOD-label [] xref: DiffAvg: "484.50" xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2" xref: DiffMono: "484.039893" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01660 name: Uniblue A derivatized cysteine def: "A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A cysteine adduct." [PubMed:18688235] subset: PSI-MOD-slim synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate [] synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate [] synonym: "SUniblueACys" EXACT PSI-MOD-label [] synonym: "Uniblue A" EXACT PSI-MOD-alternate [] xref: DiffAvg: "484.50" xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2" xref: DiffMono: "484.039893" xref: Formula: "C 25 H 21 N 3 O 8 S 3" xref: MassAvg: "587.64" xref: MassMono: "587.049078" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01659 ! Uniblue A derivatized residue [Term] id: MOD:01661 name: pyruvic acid (Tyr) def: "A protein modification that effectively converts an L-tyrosine residue to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:500639, PubMed:8464063, RESID:AA0127#TYR] synonym: "2-oxopropanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES Pyruvic acid (Tyr)" EXACT UniProt-feature [] synonym: "pyruvic acid" EXACT RESID-name [] xref: DiffAvg: "-93.13" xref: DiffFormula: "C -6 H -7 N -1 O 0" xref: DiffMono: "-93.057849" xref: Formula: "C 3 H 3 O 2" xref: MassAvg: "71.06" xref: MassMono: "71.013304" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01154 ! pyruvic acid [Term] id: MOD:01662 name: N5-(ADP-ribosyl)-L-glutamine def: "A protein modification that effectively converts an L-glutamine residue to N5-(ADP-ribosyl)-L-glutamine." [PubMed:20185726, RESID:AA0518] synonym: "(S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "N5-(ADP-ribosyl)-L-glutamine" EXACT RESID-name [] synonym: "N5-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-glutamine" EXACT RESID-alternate [] synonym: "N5-alpha-D-ribofuranosyl-L-glutamine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "C 20 H 29 N 7 O 15 P 2" xref: MassAvg: "669.43" xref: MassMono: "669.119687" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00907 ! modified L-glutamine residue [Term] id: MOD:01663 name: O-(ADP-ribosyl)-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-(ADP-ribosyl)-L-threonine." [PubMed:20185726, RESID:AA0519] synonym: "(S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-butanoic acid" EXACT RESID-systematic [] synonym: "O-(ADP-ribosyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(ADP-ribosyl)-L-threonine" EXACT RESID-alternate [] synonym: "O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-threonine" EXACT RESID-alternate [] synonym: "O3-alpha-D-ribofuranosyl-L-threonine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate [] xref: DiffAvg: "541.30" xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2" xref: DiffMono: "541.061109" xref: Formula: "C 19 H 28 N 6 O 15 P 2" xref: MassAvg: "642.41" xref: MassMono: "642.108787" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01664 name: 7'-hydroxy-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to a 7'-hydroxy-L-tryptophan." [PubMed:20223990, RESID:AA0520] synonym: "(2S)-2-amino-3-(7-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "7'-hydroxy-L-tryptophan" EXACT RESID-name [] synonym: "7-hydroxy-L-tryptophan" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 11 H 10 N 2 O 2" xref: MassAvg: "202.21" xref: MassMono: "202.074228" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01622 ! monohydroxylated tryptophan [Term] id: MOD:01665 name: N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine def: "A protein modification that effectively crosslinks an N-terminal L-valine residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine." [PubMed:20185759, RESID:AA0521] synonym: "(2S)-2-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]amino-3-methylbutanoic acid" EXACT RESID-systematic [] synonym: "ACT_SITE Schiff-base intermediate with DNA; via amino nitrogen" EXACT UniProt-feature [] synonym: "DNA glycosylase valine Schiff base intermediate" EXACT RESID-alternate [] synonym: "N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine" EXACT RESID-name [] xref: DiffAvg: "178.08" xref: DiffFormula: "C 5 H 7 N 0 O 5 P 1" xref: DiffMono: "178.003110" xref: Formula: "C 10 H 17 N 1 O 6 P 1" xref: MassAvg: "278.22" xref: MassMono: "278.079349" xref: Origin: "V" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00750 ! deoxyribonucleic acid linked residue is_a: MOD:00920 ! modified L-valine residue [Term] id: MOD:01666 name: epicocconone derivatized residue def: "A protein modification that is produced by formation of an adduct with epicocconone." [PubMed:18688235] synonym: "(6S,9aS)-6-(hydroxymethyl)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-9a-methyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione" EXACT PSI-MOD-alternate [] synonym: "Deep Purple" EXACT PSI-MOD-alternate [] synonym: "LavaPurple" EXACT PSI-MOD-alternate [] synonym: "Lightning Fast" EXACT PSI-MOD-alternate [] xref: DiffAvg: "410.42" xref: DiffFormula: "C 23 H 22 O 7" xref: DiffMono: "410.136553" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01667 name: N6-epicoccononyl lysine adduct def: "A protein modification that is produced by formation of an adduct with epicocconone." [PubMed:18688235] synonym: "(6Z,7aS)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-7a-methyl-6-[([(1S)-1-amino-1-carboxylpentyl]amino)methylidene]-5-[(2S)-2,3-dihydroxypropyl]-1-benzofuran-2,7(6H,7aH)-dione" EXACT PSI-MOD-alternate [] synonym: "DeepPurple" EXACT PSI-MOD-alternate [] synonym: "LavaPurple" EXACT PSI-MOD-alternate [] synonym: "Lightning Fast" EXACT PSI-MOD-alternate [] xref: DiffAvg: "410.42" xref: DiffFormula: "C 23 H 22 O 7" xref: DiffMono: "410.136553" xref: Formula: "C 29 H 34 N 2 O 8" xref: MassAvg: "538.60" xref: MassMono: "538.231516" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01666 ! epicocconone derivatized residue [Term] id: MOD:01668 name: O4-(8alpha-FAD)-L-aspartate def: "A protein modification that effectively converts an L-aspartic acid residue to O4-(8alpha-FAD)-L-aspartate." [PubMed:20080101, RESID:AA0522] subset: PSI-MOD-slim synonym: "(2S)-2-amino-4-oxo-4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxybutanoic acid" EXACT RESID-systematic [] synonym: "8alpha-[(4-aspartyl)oxy]FAD" EXACT RESID-alternate [] synonym: "O4-(8alpha-FAD)-L-aspartate" EXACT RESID-name [] xref: DiffAvg: "783.54" xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2" xref: DiffMono: "783.141485" xref: Formula: "C 31 H 36 N 10 O 18 P 2" xref: MassAvg: "898.63" xref: MassMono: "898.168428" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00895 ! FAD modified residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:01669 name: trimethyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to N(omega),N(omega),N'(omega)-trimethyl-L-arginine." [OMSSA:117, PubMed:11704273, PubMed:602668, RESID:AA0523, UniMod:37#R] synonym: "(2S)-2-amino-5-([(dimethylamino)(methylamino)methylidene]amino)pentanoic acid" EXACT RESID-systematic [] synonym: "(2S)-2-amino-5-([(dimethylamino)(methylimino)methyl]amino)pentanoic acid" EXACT RESID-alternate [] synonym: "2-[(4S)-4-amino-5-oxopentyl]-1,1,3-trimethylguanidine" EXACT RESID-alternate [] synonym: "N(G)-trimethylarginine" EXACT RESID-alternate [] synonym: "N5-[(dimethylamino)(imino)methyl]ornithine" EXACT RESID-alternate [] synonym: "NoNoNo'Me3Arg" EXACT PSI-MOD-label [] synonym: "omega-N,omega-N,omega-N'-trimethyl-L-arginine" EXACT RESID-name [] synonym: "tri-Methylation" RELATED UniMod-description [] synonym: "Trimethyl" RELATED PSI-MS-label [] synonym: "trimethylationr" EXACT OMSSA-label [] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6 N 0 O 0" xref: DiffMono: "42.046950" xref: Formula: "C 9 H 18 N 4 O 1" xref: MassAvg: "198.27" xref: MassMono: "198.148061" xref: Origin: "R" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00430 ! trimethylated residue is_a: MOD:00602 ! N-methylated residue is_a: MOD:00658 ! methylated arginine [Term] id: MOD:01670 name: N6-chloro-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine." [PubMed:16091367, PubMed:16195462, PubMed:17260957, RESID:AA0524] synonym: "(2S)-2-amino-6-(chloroamino)hexanoic acid" EXACT RESID-systematic [] synonym: "epsilon-chlorolysine" EXACT RESID-alternate [] synonym: "lysine chloramine" EXACT RESID-alternate [] synonym: "N(zeta)-chlorolysine" EXACT RESID-alternate [] synonym: "N6-chloro-L-lysine" EXACT RESID-name [] synonym: "N6ClLys" EXACT PSI-MOD-label [] xref: DiffAvg: "34.44" xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" xref: DiffMono: "33.961028" xref: Formula: "C 6 Cl 1 H 11 N 2 O 1" xref: MassAvg: "162.62" xref: MassMono: "162.055991" xref: Origin: "K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01672 ! halogenated lysine is_a: MOD:01911 ! monochlorinated residue [Term] id: MOD:01671 name: O-(L-isoaspartyl)-L-threonine (active site intermediate) def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using free L-asparagine and releasing ammonia." [PubMed:8706862, RESID:AA0525#THR] comment: This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate [] synonym: "ACT_SITE O-isoaspartyl threonine intermediate" EXACT UniProt-feature [] synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate [] synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate [] xref: DiffAvg: "115.09" xref: DiffFormula: "C 4 H 5 N 1 O 3" xref: DiffMono: "115.026943" xref: Formula: "C 8 H 12 N 2 O 5" xref: MassAvg: "216.19" xref: MassMono: "216.074621" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00671 ! O-acylated residue is_a: MOD:01978 ! O-(L-isoaspartyl)-L-threonine [Term] id: MOD:01672 name: halogenated lysine def: "A protein modification that effectively substitutes a hydrogen atom of an L-lysine residue with a halogen atom." [PubMed:18688235] xref: Origin: "K" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00694 ! halogen containing residue [Term] id: MOD:01673 name: N-acetylaminohexosylated residue def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminohexose group through a glycosidic bond." [UniMod:43] subset: PSI-MOD-slim synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "HexNAcRes" EXACT PSI-MOD-label [] synonym: "N-Acetylhexosamine" RELATED UniMod-description [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00436 ! N-acetylhexosaminylated [Term] id: MOD:01674 name: N4-(N-acetylamino)hexosyl-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminohexosyl)-L-asparagine." [OMSSA:182, UniMod:43#N] subset: PSI-MOD-slim synonym: "(S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)amino-4-oxobutanoic acid" EXACT PSI-MOD-alternate [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "HexNAcAsn" EXACT PSI-MOD-label [] synonym: "hexNAcN" EXACT OMSSA-label [] synonym: "N-Acetylhexosamine" RELATED UniMod-description [] synonym: "N4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-asparagine" EXACT PSI-MOD-alternate [] synonym: "N4-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-asparagine" EXACT PSI-MOD-alternate [] synonym: "N4-(N-acetylhexosaminyl)asparagine" EXACT PSI-MOD-alternate [] synonym: "N4-asparagine-beta-N-acetylhexosaminide" EXACT PSI-MOD-alternate [] synonym: "N4-glycosyl-L-asparagine" EXACT PSI-MOD-alternate [] synonym: "N4-glycosylasparagine" EXACT PSI-MOD-alternate [] synonym: "N4HexNAcAsn" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 12 H 19 N 3 O 7" xref: MassAvg: "317.30" xref: MassMono: "317.122300" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00160 ! N4-glycosyl-L-asparagine is_a: MOD:01673 ! N-acetylaminohexosylated residue [Term] id: MOD:01675 name: O-(N-acetylamino)hexosyl-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminohexosyl)-L-serine." [OMSSA:184, UniMod:43#S] subset: PSI-MOD-slim synonym: "(S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-hexopyranosyloxy)propanoic acid" EXACT PSI-MOD-alternate [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "hexNAcS" EXACT OMSSA-label [] synonym: "N-Acetylhexosamine" RELATED UniMod-description [] synonym: "O-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-serine" EXACT PSI-MOD-alternate [] synonym: "O-(N-acetylhexosaminyl)serine" EXACT PSI-MOD-alternate [] synonym: "O-glycosylserine" EXACT PSI-MOD-alternate [] synonym: "O-seryl-beta-N-acetylhexosaminide" EXACT PSI-MOD-alternate [] synonym: "O3-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-serine" EXACT PSI-MOD-alternate [] synonym: "OHexNAcSer" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 11 H 18 N 2 O 7" xref: MassAvg: "290.27" xref: MassMono: "290.111401" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine is_a: MOD:01673 ! N-acetylaminohexosylated residue [Term] id: MOD:01676 name: O-(N-acetylamino)hexosyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminohexosyl)-L-threonine." [OMSSA:185, UniMod:43#T] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-(alpha-D-2-acetamido-2-deoxyhexopyranosyloxy)butanoic acid" EXACT PSI-MOD-alternate [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "hexNAcT" EXACT OMSSA-label [] synonym: "N-Acetylhexosamine" RELATED UniMod-description [] synonym: "O-(N-acetylhexcosaminyl)-L-threonine" EXACT PSI-MOD-alternate [] synonym: "O-glycosylthreonine" EXACT PSI-MOD-alternate [] synonym: "O3-(N-acetylhexosaminyl)threonine" EXACT PSI-MOD-alternate [] synonym: "OHexNAcThr" EXACT PSI-MOD-label [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 12 H 20 N 2 O 7" xref: MassAvg: "304.30" xref: MassMono: "304.127051" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00005 ! O-glycosyl-L-threonine is_a: MOD:01673 ! N-acetylaminohexosylated residue [Term] id: MOD:01677 name: O4-(N-acetylamino)hexosyl-L-hydroxyproline def: "A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)hexosyl-L-hydroxyproline." [PubMed:18688235] comment: secondary to RESID:AA0030 subset: PSI-MOD-slim synonym: "(2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-hexopyranosyloxy]pyrrolidine-2-carboxylic acid" EXACT PSI-MOD-alternate [] synonym: "4-(N-acetylhexosaminyloxy)proline" EXACT PSI-MOD-alternate [] synonym: "4-[(2-N-acetylamino)-alpha-D-hexopyranosyl]oxyproline" EXACT PSI-MOD-alternate [] synonym: "alpha-2-(N-acetylamino)hexopyranosyl-4-hydroxyproline" EXACT PSI-MOD-alternate [] synonym: "HexNAc" RELATED PSI-MS-label [] synonym: "O4-glycosyl-hydroxyproline" EXACT PSI-MOD-alternate [] synonym: "O4HexNAcHyPro" EXACT PSI-MOD-label [] xref: DiffAvg: "219.19" xref: DiffFormula: "C 8 H 13 N 1 O 6" xref: DiffMono: "219.074287" xref: Formula: "C 13 H 20 N 2 O 7" xref: MassAvg: "316.31" xref: MassMono: "316.127051" xref: Origin: "P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01673 ! N-acetylaminohexosylated residue [Term] id: MOD:01678 name: N6-carbamoyl-L-lysine def: "A protein modification that effectively coverts L-lysine to N6-carbamoyl-L-lysine." [DeltaMass:56, OMSSA:31, PubMed:10978403, PubMed:12203680, UniMod:5#K] comment: This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation in solution [JSG]. subset: PSI-MOD-slim synonym: "2-amino-6-ureido-hexanoic acid" EXACT PSI-MOD-alternate [] synonym: "Carbamyl" RELATED UniMod-interim [] synonym: "Carbamylation" RELATED UniMod-description [] synonym: "carbamylk" EXACT OMSSA-label [] synonym: "homocitrulline" EXACT PSI-MOD-alternate [] synonym: "N6-(aminocarbonyl)-L-lysine" EXACT PSI-MOD-alternate [] synonym: "N6CbmLys" EXACT PSI-MOD-label [] xref: DiffAvg: "43.02" xref: DiffFormula: "C 1 H 1 N 1 O 1" xref: DiffMono: "43.005814" xref: Formula: "C 7 H 13 N 3 O 2" xref: MassAvg: "171.20" xref: MassMono: "171.100777" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00398 ! carbamoylated residue [Term] id: MOD:01679 name: alpha-aminocarbamoylated residue def: "A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a carbamoyl group." [DeltaMass:56, OMSSA:32, PubMed:10978403, PubMed:12203680, UniMod:5#N-term] comment: This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation. This modification effectively blocks Edman degradation, and because it can dehydrate to a cyanate group and react with another peptide N-terminal, it can effectively block two peptide molecules [JSG]. subset: PSI-MOD-slim synonym: "Carbamyl" RELATED UniMod-interim [] synonym: "Carbamylation" RELATED UniMod-description [] synonym: "N2CbmRes" EXACT PSI-MOD-label [] synonym: "ntermcarbamyl" EXACT OMSSA-label [] xref: DiffAvg: "43.02" xref: DiffFormula: "C 1 H 1 N 1 O 1" xref: DiffMono: "43.005814" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00398 ! carbamoylated residue [Term] id: MOD:01680 name: alpha-amino monomethylated residue def: "A protein modification that effectively replaces one residue alpha amino or imino hydrogen with one methyl group." [OMSSA:11, OMSSA:76, UniMod:34#N-term] comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. subset: PSI-MOD-slim synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "N2Me1Res" EXACT PSI-MOD-label [] synonym: "ntermmethyl" EXACT OMSSA-label [] synonym: "ntermpepmethyl" EXACT OMSSA-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00599 ! monomethylated residue is_a: MOD:01460 ! alpha-amino methylated residue [Term] id: MOD:01681 name: monomethylated L-aspartic acid def: "A protein modification that effectively replaces one hydrogen atom of an L-aspartic acid residue with one methyl group." [OMSSA:16, UniMod:34#D] synonym: "Me1Asp" EXACT PSI-MOD-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "methyld" EXACT OMSSA-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 5 H 7 N 1 O 3" xref: MassAvg: "129.12" xref: MassMono: "129.042593" xref: Origin: "D" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00887 ! methylated aspartic acid [Term] id: MOD:01682 name: monomethylated L-cysteine def: "A protein modification that effectively replaces one hydrogen atom of an L-cysteine residue with one methyl group." [OMSSA:73, UniMod:34#C] subset: PSI-MOD-slim synonym: "Me1Cys" EXACT PSI-MOD-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "methylc" EXACT OMSSA-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 4 H 7 N 1 O 1 S 1" xref: MassAvg: "117.17" xref: MassMono: "117.024835" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00660 ! methylated cysteine [Term] id: MOD:01683 name: monomethylated L-lysine def: "A protein modification that effectively replaces one hydrogen atom of an L-lysine residue with one methyl group." [OMSSA:0] subset: PSI-MOD-slim synonym: "Me1Lys" EXACT PSI-MOD-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methylation" RELATED UniMod-description [] synonym: "methylk" EXACT OMSSA-label [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 7 H 15 N 2 O 2" xref: MassAvg: "159.21" xref: MassMono: "159.113353" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00599 ! monomethylated residue is_a: MOD:00663 ! methylated lysine [Term] id: MOD:01684 name: palmitoylated-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine." [OMSSA:92, UniMod:47] subset: PSI-MOD-slim synonym: "Palmitoyl" RELATED PSI-MS-label [] synonym: "Palmitoylation" RELATED UniMod-description [] synonym: "palmitoylationc" EXACT OMSSA-label [] synonym: "PamCys" EXACT PSI-MOD-label [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" xref: DiffMono: "238.229666" xref: Formula: "C 19 H 35 N 1 O 2 S 1" xref: MassAvg: "341.55" xref: MassMono: "341.238850" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00440 ! palmitoylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01685 name: alpha-amino palmitoylated residue def: "A protein modification that effectively replaces a residue alpha-amino group with a alpha-palmitoylamino group." [UniMod:47#N-term] subset: PSI-MOD-slim synonym: "N2PamRes" EXACT PSI-MOD-label [] synonym: "Palmitoyl" RELATED PSI-MS-label [] synonym: "Palmitoylation" RELATED UniMod-description [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" xref: DiffMono: "238.229666" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00651 ! N-palmitoylated residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:01686 name: alpha-amino dimethylated residue def: "A protein modification that effectively replaces two alpha amino hydrogen atoms with two methyl group." [OMSSA:38, UniMod:36#N-term] comment: For alpha-amino acids, both N-alpha-monomethylation and complete N-alpha protonation and trimethylation have been observed, but incomplete dimethylation has not been reported as a natural process. For N-terminal proline residues, dimethylation can only be effectively accomplished with a protonated imino group, whereas this process accounts only for dimethylation and not protonation. See MOD:00889. synonym: "di-Methylation" RELATED UniMod-description [] synonym: "Dimethyl" RELATED PSI-MS-label [] synonym: "N2Me2Res" EXACT PSI-MOD-label [] synonym: "ntermpepdimethyl" EXACT OMSSA-label [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4" xref: DiffMono: "28.031300" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "N-term" is_a: MOD:00429 ! dimethylated residue is_a: MOD:01460 ! alpha-amino methylated residue [Term] id: MOD:01687 name: alpha-amino trimethylated residue def: "A protein modification that effectively replaces an alpha-aminium group with a trimethylaminium group." [OMSSA:12, UniMod:37#N-term] comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Res process (MOD:01698) accounts for both protonation and trimethylation. subset: PSI-MOD-slim synonym: "N2Me3Res" EXACT PSI-MOD-label [] synonym: "ntermtrimethyl" EXACT OMSSA-label [] synonym: "tri-Methylation" RELATED UniMod-description [] synonym: "Trimethyl" RELATED PSI-MS-label [] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6 N 0 O 0" xref: DiffMono: "42.046402" xref: FormalCharge: "1+" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00430 ! trimethylated residue is_a: MOD:01460 ! alpha-amino methylated residue relationship: derives_from MOD:01700 ! alpha-amino protonated residue [Term] id: MOD:01688 name: 3-hydroxy-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to one of the diastereomeric 3-hydroxy-L-asparagine residues." [OMSSA:61, UniMod:35#N] subset: PSI-MOD-slim synonym: "3HyAsn" EXACT PSI-MOD-label [] synonym: "hydroxylationn" EXACT OMSSA-label [] synonym: "monohydroxylated asparagine" EXACT PSI-MOD-alternate [] synonym: "Oxidation" RELATED PSI-MS-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 4 H 6 N 2 O 3" xref: MassAvg: "130.10" xref: MassMono: "130.037842" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00903 ! modified L-asparagine residue [Term] id: MOD:01689 name: alpha-carboxyl methylated residue def: "A protein modification that effectively converts a carboxyl-terminal residue to an alpha-carboxyl (1-carboxyl) methyl ester." [OMSSA:18, OMSSA:68, UniMod:34#C-term] subset: PSI-MOD-slim synonym: "C1OMeRes" EXACT PSI-MOD-label [] synonym: "ctermpepmeester" EXACT OMSSA-label [] synonym: "ctermpepmethyl" EXACT OMSSA-label [] synonym: "Methyl" RELATED PSI-MS-label [] synonym: "Methyl" RELATED UniMod-alternate [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0" xref: DiffMono: "14.015650" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00393 ! O-methylated residue [Term] id: MOD:01690 name: N-[(12R)-12-hydroxymyristoyl]-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to N-[(12R)-12-hydroxymyristoyl]-L-cysteine." [RESID:AA0516] synonym: "2-[(12R)-12-hydroxytetradecanoyl]amino-3-sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "LIPID N-[(12R)-12-hydroxymyristoyl]cysteine" EXACT UniProt-feature [] synonym: "N-[(12R)-12-hydroxymyristoyl]-L-cysteine" EXACT RESID-name [] synonym: "N-[(12R)-12-hydroxytetradecanoyl]cysteine" EXACT RESID-alternate [] xref: DiffAvg: "226.36" xref: DiffFormula: "C 14 H 26 N 0 O 2 S 0" xref: DiffMono: "226.193280" xref: Formula: "C 17 H 32 N 1 O 3 S 1" xref: MassAvg: "330.51" xref: MassMono: "330.210290" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:01691 name: N-(12-ketomyristoyl)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to N-(12-ketomyristoyl)-L-cysteine." [PubMed:19053188, RESID:AA0517] synonym: "2-(12-oxotetradecanoyl)amino-3-sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "LIPID N-(12-oxomyristoyl)cysteine" EXACT UniProt-feature [] synonym: "N-(12-ketomyristoyl)-L-cysteine" EXACT RESID-name [] synonym: "N-(12-oxotetradecanoyl)cysteine" EXACT RESID-alternate [] xref: DiffAvg: "224.34" xref: DiffFormula: "C 14 H 24 N 0 O 2 S 0" xref: DiffMono: "224.177630" xref: Formula: "C 17 H 30 N 1 O 3 S 1" xref: MassAvg: "328.49" xref: MassMono: "328.194640" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:01692 name: glutamyl semialdehyde (Glu) def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl semialdehyde." [PubMed:18688235, PubMed:743268] synonym: "Deoxy" RELATED PSI-MS-label [] synonym: "gamma-glutamyl semialdehyde" EXACT PSI-MOD-alternate [] synonym: "glutamyl 5-semialdehyde" EXACT PSI-MOD-alternate [] synonym: "glutamyl aldehyde" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-16.00" xref: DiffFormula: "C 0 H 0 N 0 O -1" xref: DiffMono: "-15.994915" xref: Formula: "C 5 H 7 N 1 O 2" xref: MassAvg: "113.12" xref: MassMono: "113.047678" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01161 ! deoxygenated residue is_a: MOD:01440 ! glutamyl semialdehyde [Term] id: MOD:01693 name: alpha-amino pyridylacetylated residue def: "A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a (pyrid-3-yl)acetyl group." [OMSSA:107, PubMed:9276974, UniMod:25#N-term] comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. synonym: "ntermpeppyridyl" EXACT OMSSA-label [] synonym: "Pyridylacetyl" RELATED PSI-MS-label [] synonym: "pyridylacetyl" RELATED UniMod-description [] xref: DiffAvg: "119.12" xref: DiffFormula: "C 7 H 5 N 1 O 1" xref: DiffMono: "119.037114" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00418 ! pyridylacetylated residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:01694 name: S-(coelenterazin-3a-yl)-L-cysteine def: "A protein modification that effectively results from forming an adduct between an L-cysteine residue and the bioluminescent compound didehydrocoelenterazine to form S-(coelenterazin-3a-yl)-L-cysteine." [ChEBI:2311, PubMed:18997450, RESID:AA0526] synonym: "(2R)-2-amino-3-([(4-hydroxyphenyl)(8-benzyl-3-oxo-6-[4-hydroxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)methyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "dehydrocoelenterazine cysteine adduct" EXACT RESID-alternate [] synonym: "MOD_RES S-(coelenterazin-3a-yl)cysteine" EXACT UniProt-feature [] synonym: "S-(coelenterazin-3a-yl)-L-cysteine" EXACT RESID-name [] synonym: "symplectin chromophore" EXACT RESID-alternate [] xref: DiffAvg: "421.46" xref: DiffFormula: "C 26 H 19 N 3 O 3 S 0" xref: DiffMono: "421.142641" xref: Formula: "C 29 H 24 N 4 O 4 S 1" xref: MassAvg: "524.60" xref: MassMono: "524.151826" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01695 name: alpha-amino 3-(carboxamidomethylthio)propanoylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 3-(carboxamidomethylthio)propanoyl group." [PubMed:15121203, UniMod:293#N-term] synonym: "3-(carbamidomethylthio)propanoyl" RELATED UniMod-description [] synonym: "CAMthiopropanoyl" RELATED PSI-MS-label [] xref: DiffAvg: "145.18" xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1" xref: DiffMono: "145.019749" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00612 ! 3-(carboxamidomethylthio)propanoylated residue is_a: MOD:01696 ! alpha-amino acylated residue [Term] id: MOD:01696 name: alpha-amino acylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00670 ! N-acylated residue [Term] id: MOD:01697 name: alpha-amino 4-(2-aminoethyl)benzenesulfonylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 4-(2-aminoethyl)benzenesulfonyl group." [DeltaMass:235, PubMed:8597590, UniMod:276#N-term] comment: See the comment for MOD:00596 [JSG]. synonym: "AEBS" RELATED PSI-MS-label [] synonym: "Aminoethylbenzenesulfonylation" RELATED UniMod-description [] xref: DiffAvg: "183.23" xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1" xref: DiffMono: "183.035400" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue [Term] id: MOD:01698 name: alpha-amino trimethylated protonated-residue def: "A protein modification that effectively replaces an amino group with a trimethylaminium group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "N2Me3+Res" EXACT PSI-MOD-label [] synonym: "tri-Methylation" RELATED UniMod-description [] synonym: "Trimethyl" RELATED PSI-MS-label [] xref: DiffAvg: "43.09" xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0" xref: DiffMono: "43.054227" xref: FormalCharge: "1+" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00711 ! trimethylated protonated-residue is_a: MOD:01460 ! alpha-amino methylated residue [Term] id: MOD:01699 name: protonated residue def: "A protein modification that effectively adds a hydrogen cation, a proton, forming a cationic residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "H+NRes" EXACT PSI-MOD-label [] xref: DiffAvg: "1.01" xref: DiffFormula: "C 0 H 1 N 0 O 0" xref: DiffMono: "1.007276" xref: FormalCharge: "1+" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01700 name: alpha-amino protonated residue def: "A protein modification that effectively adds a proton to a residue alpha-amnino or alpha-imino group forming an alpha-aminium or alpha-iminium group, respectively." [PubMed:18688235] subset: PSI-MOD-slim synonym: "N2H+NRes" EXACT PSI-MOD-label [] xref: DiffAvg: "1.01" xref: DiffFormula: "C 0 H 1 N 0 O 0" xref: DiffMono: "1.007276" xref: FormalCharge: "1+" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01699 ! protonated residue [Term] id: MOD:01701 name: deprotonated residue def: "A protein modification that effectively removes a hydrogen cation, a proton, forming an anionic residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "H-NRes" EXACT PSI-MOD-label [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0" xref: DiffMono: "-1.007276" xref: FormalCharge: "1-" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01156 ! protein modification categorized by chemical process [Term] id: MOD:01702 name: alpha-carboxyl deprotonated residue def: "A protein modification that effectively removes a proton from a residue 1-carboxyl group (referred to as the alpha-carboxyl), forming a carboxylate anion." [PubMed:18688235] subset: PSI-MOD-slim synonym: "C1H-NRes" EXACT PSI-MOD-label [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0" xref: DiffMono: "-1.007276" xref: FormalCharge: "1-" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01701 ! deprotonated residue [Term] id: MOD:01703 name: dehydrobutyrine def: "A protein modification that effectively converts a source amino acid residue to dehydrobutyrine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "beta-elim-t" EXACT OMSSA-label [] synonym: "Dehydrated" RELATED PSI-MS-label [] synonym: "Dehydrated" RELATED UniMod-interim [] synonym: "Dehydration" RELATED UniMod-description [] synonym: "dehydro" EXACT OMSSA-label [] synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label [] synonym: "dHAbu" EXACT PSI-MOD-label [] synonym: "phospholosst" EXACT OMSSA-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 4 H 5 N 1 O 1" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01704 name: dehydrobutyrine (Met) def: "A protein modification that effectively converts an L-methionine residue to dehydrobutyrine, by neutral loss of methyl sulfide." [PubMed:18688235] comment: It is expected that this neutral loss will produce a mix of (E)- and (Z)-isomers [JSG]. subset: PSI-MOD-slim synonym: "dHAbu(Met)" EXACT PSI-MOD-label [] xref: DiffAvg: "-48.10" xref: DiffFormula: "C -1 H -4 N 0 O 0 S -1" xref: DiffMono: "-48.003371" xref: Formula: "C 4 H 5 N 1 O 1" xref: MassAvg: "83.09" xref: MassMono: "83.037114" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01703 ! dehydrobutyrine [Term] id: MOD:01705 name: isotope tagged reagent acylated residue def: "A protein modification that effectively replaces a residue hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue [Term] id: MOD:01706 name: isotope tagged reagent N-acylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00670 ! N-acylated residue [Term] id: MOD:01707 name: isotope tagged reagent O-acylated residue def: "A protein modification that effectively replaces a residue hydroxyl group with an isotope tagged reagent acyloxy group." [PubMed:18688235] xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00671 ! O-acylated residue [Term] id: MOD:01708 name: isotope tagged reagent alpha-amino acylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01696 ! alpha-amino acylated residue is_a: MOD:01705 ! isotope tagged reagent acylated residue is_a: MOD:01706 ! isotope tagged reagent N-acylated residue [Term] id: MOD:01709 name: iTRAQ4plex reporter+balance reagent N-acylated residue def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01706 ! isotope tagged reagent N-acylated residue [Term] id: MOD:01710 name: iTRAQ8plex reporter+balance reagent N-acylated residue def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01706 ! isotope tagged reagent N-acylated residue [Term] id: MOD:01711 name: iTRAQ4plex reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [UniMod:214#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue [Term] id: MOD:01712 name: iTRAQ8plex reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [UniMod:214#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue [Term] id: MOD:01713 name: iTRAQ4plex reporter+balance reagent O-acylated residue def: "A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance acyloxy groups." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01707 ! isotope tagged reagent O-acylated residue [Term] id: MOD:01714 name: iTRAQ8plex reporter+balance reagent O-acylated residue def: "A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance acyloxy groups." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01707 ! isotope tagged reagent O-acylated residue [Term] id: MOD:01715 name: TMT6plex reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with a Proteome Sciences TMT6plex reporter+balance group." [UniMod:214] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01705 ! isotope tagged reagent acylated residue [Term] id: MOD:01716 name: TMT6plex reporter fragment def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] synonym: "cysTMT6plex reporter fragment" EXACT PSI-MOD-alternate [] is_a: MOD:01520 ! modification reporter fragment relationship: derives_from MOD:01715 ! TMT6plex reporter+balance reagent acylated residue relationship: derives_from MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide [Term] id: MOD:01717 name: TMT6plex reporter+balance reagent N-acylated residue def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01706 ! isotope tagged reagent N-acylated residue [Term] id: MOD:01718 name: TMT6plex reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group." [UniMod:214#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue [Term] id: MOD:01719 name: TMT6plex reporter+balance reagent O-acylated residue def: "A protein modification that effectively replaces a residue hydroxyl with one of the Proteome Sciences TMT6plex reagent reporter+balance acyloxy groups." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01707 ! isotope tagged reagent O-acylated residue [Term] id: MOD:01720 name: TMT6plex-126 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [UniMod:737] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue [Term] id: MOD:01721 name: TMT6plex-126 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-126 reporter+balance group." [UniMod:737#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue [Term] id: MOD:01722 name: TMT6plex-126 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [UniMod:737#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" xref: MassAvg: "357.26" xref: MassMono: "357.257895" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01723 name: TMT6plex-126 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [UniMod:737#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" xref: MassAvg: "392.23" xref: MassMono: "392.226261" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue [Term] id: MOD:01724 name: TMT6plex-126 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" xref: MassAvg: "366.22" xref: MassMono: "366.221844" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue [Term] id: MOD:01725 name: TMT6plex-126 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" xref: MassAvg: "316.19" xref: MassMono: "316.194961" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue [Term] id: MOD:01726 name: TMT6plex-126 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" xref: MassAvg: "330.21" xref: MassMono: "330.210611" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue [Term] id: MOD:01727 name: TMT6plex-126 reporter fragment def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] synonym: "cysTMT6plex-126 reporter fragment" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 8 H 16 (14)N 1" xref: MassAvg: "126.13" xref: MassMono: "126.127726" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01716 ! TMT6plex reporter fragment relationship: derives_from MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue relationship: derives_from MOD:01822 ! cysTMT6plex-zero reporter+balance reagent cysteine disulfide relationship: derives_from MOD:01823 ! cysTMT6plex-126 reporter+balance reagent cysteine disulfide [Term] id: MOD:01728 name: TMT6plex-127 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [UniMod:737] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue [Term] id: MOD:01729 name: TMT6plex-127 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-127 reporter+balance group." [UniMod:737#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue [Term] id: MOD:01730 name: TMT6plex-127 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [UniMod:737#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" xref: MassAvg: "357.26" xref: MassMono: "357.257895" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01731 name: TMT6plex-127 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [UniMod:737#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: MassAvg: "229.16" xref: MassMono: "229.162932" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue [Term] id: MOD:01732 name: TMT6plex-127 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" xref: MassAvg: "366.22" xref: MassMono: "366.221844" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue [Term] id: MOD:01733 name: TMT6plex-127 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" xref: MassAvg: "316.19" xref: MassMono: "316.194961" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue [Term] id: MOD:01734 name: TMT6plex-127 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" xref: MassAvg: "330.21" xref: MassMono: "330.210611" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue [Term] id: MOD:01735 name: TMT6plex-127 reporter fragment def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-127 reagent acylated residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] synonym: "cysTMT6plex-127 reporter fragment" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 7 (13)C 1 H 16 (14)N 1" xref: MassAvg: "127.13" xref: MassMono: "127.131081" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01716 ! TMT6plex reporter fragment relationship: derives_from MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue relationship: derives_from MOD:01824 ! cysTMT6plex-127 reporter+balance reagent cysteine disulfide [Term] id: MOD:01736 name: TMT6plex-128 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [UniMod:737] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue [Term] id: MOD:01737 name: TMT6plex-128 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-128 reporter+balance group." [UniMod:737#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue [Term] id: MOD:01738 name: TMT6plex-128 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [UniMod:737#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" xref: MassAvg: "357.26" xref: MassMono: "357.257895" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01739 name: TMT6plex-128 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [UniMod:737#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" xref: MassAvg: "392.23" xref: MassMono: "392.226261" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue [Term] id: MOD:01740 name: TMT6plex-128 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" xref: MassAvg: "366.22" xref: MassMono: "366.221844" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue [Term] id: MOD:01741 name: TMT6plex-128 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" xref: MassAvg: "316.19" xref: MassMono: "316.194961" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue [Term] id: MOD:01742 name: TMT6plex-128 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" xref: MassAvg: "330.21" xref: MassMono: "330.210611" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue [Term] id: MOD:01743 name: TMT6plex-128 reporter fragment def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-128 reagent acylated residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] synonym: "cysTMT6plex-128 reporter fragment" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 6 (13)C 2 H 16 (14)N 1" xref: MassAvg: "128.13" xref: MassMono: "128.134436" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01716 ! TMT6plex reporter fragment relationship: derives_from MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue relationship: derives_from MOD:01825 ! cysTMT6plex-128 reporter+balance reagent cysteine disulfide [Term] id: MOD:01744 name: TMT6plex-129 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [UniMod:737] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue [Term] id: MOD:01745 name: TMT6plex-129 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-129 reporter+balance group." [UniMod:737#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue [Term] id: MOD:01746 name: TMT6plex-129 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [UniMod:737#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" xref: MassAvg: "357.26" xref: MassMono: "357.257895" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01747 name: TMT6plex-129 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [UniMod:737#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" xref: MassAvg: "392.23" xref: MassMono: "392.226261" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue [Term] id: MOD:01748 name: TMT6plex-129 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" xref: MassAvg: "366.22" xref: MassMono: "366.221844" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue [Term] id: MOD:01749 name: TMT6plex-129 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" xref: MassAvg: "316.19" xref: MassMono: "316.194961" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue [Term] id: MOD:01750 name: TMT6plex-129 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" xref: MassAvg: "330.21" xref: MassMono: "330.210611" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue [Term] id: MOD:01751 name: TMT6plex-129 reporter fragment def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-129 reagent acylated residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] synonym: "cysTMT6plex-129 reporter fragment" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 5 (13)C 3 H 16 (14)N 1" xref: MassAvg: "129.14" xref: MassMono: "129.137790" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01716 ! TMT6plex reporter fragment relationship: derives_from MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue relationship: derives_from MOD:01826 ! cysTMT6plex-129 reporter+balance reagent cysteine disulfide [Term] id: MOD:01752 name: TMT6plex-130 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [UniMod:737] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue relationship: derives_from MOD:01827 ! cysTMT6plex-130 reporter+balance reagent cysteine disulfide [Term] id: MOD:01753 name: TMT6plex-130 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-130 reporter+balance group." [UniMod:737#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue [Term] id: MOD:01754 name: TMT6plex-130 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [UniMod:737#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" xref: MassAvg: "357.26" xref: MassMono: "357.257895" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01755 name: TMT6plex-130 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [UniMod:737#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" xref: MassAvg: "392.23" xref: MassMono: "392.226261" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue [Term] id: MOD:01756 name: TMT6plex-130 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" xref: MassAvg: "366.22" xref: MassMono: "366.221844" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue [Term] id: MOD:01757 name: TMT6plex-130 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" xref: MassAvg: "316.19" xref: MassMono: "316.194961" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue [Term] id: MOD:01758 name: TMT6plex-130 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" xref: MassAvg: "330.21" xref: MassMono: "330.210611" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue [Term] id: MOD:01759 name: TMT6plex-130 reporter fragment def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-130 reagent acylated residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] synonym: "cysTMT6plex-130 reporter fragment" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 4 (13)C 4 H 16 (14)N 1" xref: MassAvg: "130.14" xref: MassMono: "130.141145" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01716 ! TMT6plex reporter fragment relationship: derives_from MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue [Term] id: MOD:01760 name: TMT6plex-131 reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [UniMod:737] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "cysTMT6plex-131 reporter fragment" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue relationship: derives_from MOD:01828 ! cysTMT6plex-131 reporter+balance reagent cysteine disulfide [Term] id: MOD:01761 name: TMT6plex-131 reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-131 reporter+balance group." [UniMod:737#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue [Term] id: MOD:01762 name: TMT6plex-131 reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [UniMod:737#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3" xref: MassAvg: "357.26" xref: MassMono: "357.257895" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01763 name: TMT6plex-131 reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [UniMod:737#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4" xref: MassAvg: "392.23" xref: MassMono: "392.226261" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue [Term] id: MOD:01764 name: TMT6plex-131 reporter+balance reagent N'-acylated histidine def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3" xref: MassAvg: "366.22" xref: MassMono: "366.221844" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue [Term] id: MOD:01765 name: TMT6plex-131 reporter+balance reagent O3-acylated serine def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4" xref: MassAvg: "316.19" xref: MassMono: "316.194961" xref: Origin: "S" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue [Term] id: MOD:01766 name: TMT6plex-131 reporter+balance reagent O3-acylated threonine def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "229.16" xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2" xref: DiffMono: "229.162932" xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4" xref: MassAvg: "330.21" xref: MassMono: "330.210611" xref: Origin: "T" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue [Term] id: MOD:01767 name: TMT6plex-131 reporter fragment def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-131 reagent acylated residue." [PubMed:18688235] synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate [] synonym: "Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "TMT6plex" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 4 (13)C 4 H 16 (15)N 1" xref: MassAvg: "131.14" xref: MassMono: "131.138180" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01716 ! TMT6plex reporter fragment relationship: derives_from MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue [Term] id: MOD:01768 name: O-palmitoleylated residue def: "A protein modification that effectively replaces a residue hydroxyl group with a palmitoleyloxy group." [PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "236.40" xref: DiffFormula: "C 16 H 28 N 0 O 1" xref: DiffMono: "236.214016" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00671 ! O-acylated residue is_a: MOD:01423 ! palmitoleylated residue [Term] id: MOD:01769 name: O-palmitoleyl-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-palmitoleyl-L-threonine." [OMSSA:188, PubMed:6642431, PubMed:8413602, RESID:AA0079#var, UniMod:431#T] subset: PSI-MOD-slim synonym: "(2S,3R)-2-amino-3-((Z)-9-hexadecenoyloxy)butanoic acid" EXACT PSI-MOD-alternate [] synonym: "L-threonine cis-9-hexadecenoate ester" EXACT PSI-MOD-alternate [] synonym: "mod188" EXACT OMSSA-label [] synonym: "O-palmitoleylated L-threonine" EXACT PSI-MOD-alternate [] synonym: "O3-palmitoleyl-threonine" EXACT PSI-MOD-alternate [] synonym: "Palmitoleyl" RELATED PSI-MS-label [] synonym: "palmitoleyl" RELATED UniMod-description [] xref: DiffAvg: "236.40" xref: DiffFormula: "C 16 H 28 N 0 O 1" xref: DiffMono: "236.214016" xref: Formula: "C 20 H 35 N 1 O 3" xref: MassAvg: "337.50" xref: MassMono: "337.261694" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01768 ! O-palmitoleylated residue [Term] id: MOD:01770 name: O-palmitoyl-L-threonine amide def: "A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine amide." [PubMed:8413602, RESID:AA0079#var, RESID:AA0097#var] synonym: "(2S,3R)-2-amino-3-(hexadecanoyloxy)butanamide" EXACT PSI-MOD-alternate [] synonym: "OPamThrN" EXACT PSI-MOD-label [] xref: DiffAvg: "254.44" xref: DiffFormula: "C 16 H 32 N 1 O 1" xref: DiffMono: "254.248390" xref: Formula: "C 20 H 39 N 2 O 3" xref: MassAvg: "355.54" xref: MassMono: "355.296068" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00917 ! modified L-threonine residue relationship: has_functional_parent MOD:00088 ! O-palmitoyl-L-threonine relationship: has_functional_parent MOD:00106 ! L-threonine amide [Term] id: MOD:01771 name: farnesyl reporter fragment def: "The farnesyl cation protein modification reporter fragment produced by fragmentation of some farnesyl modified residues." [PubMed:15609361, PubMed:18688235] subset: PSI-MOD-slim synonym: "(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylium" EXACT PSI-MOD-alternate [] synonym: "Farn+" EXACT PSI-MOD-label [] synonym: "farnesyl cation" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "C 15 H 25" xref: MassAvg: "205.36" xref: MassMono: "205.195077" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01520 ! modification reporter fragment relationship: derives_from MOD:00437 ! farnesylated residue [Term] id: MOD:01772 name: palmityl reporter fragment def: "The palmityl cation protein modification reporter fragment produced by fragmentation of some palmitoyl modified residues." [PubMed:18688235, PubMed:8413602] subset: PSI-MOD-slim synonym: "palmityl cation" RELATED PSI-MS-label [] synonym: "Pam+" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "C 16 H 31 O 1" xref: MassAvg: "239.42" xref: MassMono: "239.236942" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01520 ! modification reporter fragment relationship: derives_from MOD:00440 ! palmitoylated residue [Term] id: MOD:01773 name: N6,N6,N6-trimethyl-L-lysine with neutral loss of trimethylamine def: "Covalent modification of a trimethyllysine residue with secondary loss of a neutral trimethylamine molecular fragment." [PubMed:17205979, PubMed:18688235] subset: PSI-MOD-slim synonym: "dMe3N6Me3+Lys" EXACT PSI-MOD-label [] xref: DiffAvg: "-59.11" xref: DiffFormula: "C -3 H -9 N -1 O 0" xref: DiffMono: "-59.074048" xref: FormalCharge: "1+" xref: Formula: "C 6 H 10 N 1 O 1" xref: MassAvg: "112.15" xref: MassMono: "112.075690" xref: Origin: "MOD:00083" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00431 ! modified residue with a secondary neutral loss is_a: MOD:00912 ! modified L-lysine residue relationship: derives_from MOD:00083 ! N6,N6,N6-trimethyl-L-lysine [Term] id: MOD:01774 name: N6-octanoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-octanoyl-L-lysine." [PubMed:12591875, PubMed:2215217, RESID:AA0527] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-(octanoylamino)hexanoic acid" EXACT RESID-systematic [] synonym: "epsilon-octanoyllysine" EXACT RESID-alternate [] synonym: "N(zeta)-octanoyllysine" EXACT RESID-alternate [] synonym: "N6-(1-oxooctyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-octanoyl-L-lysine" EXACT RESID-name [] xref: DiffAvg: "126.20" xref: DiffFormula: "C 8 H 14 N 0 O 1" xref: DiffMono: "126.104465" xref: Formula: "C 14 H 26 N 2 O 2" xref: MassAvg: "254.37" xref: MassMono: "254.199428" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00666 ! octanoylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01775 name: 5-glutamyl serotonin def: "A protein modification that effectively converts an L-glutamine residue to 5-glutamyl serotonin." [PubMed:11805836, PubMed:14697203, RESID:AA0528] synonym: "(2S)-2-amino-5-([2-(5-hydroxy-1H-indol-3-yl)ethyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "5-glutamyl serotonin" EXACT RESID-name [] synonym: "N2-(gamma-glutamyl)-5-hydoxytryptamine" EXACT RESID-alternate [] synonym: "N5-[2-(5-hydroxy-3-indolyl)ethyl]glutamine" EXACT RESID-alternate [] xref: DiffAvg: "159.19" xref: DiffFormula: "C 10 H 9 N 1 O 1" xref: DiffMono: "159.068414" xref: Formula: "C 15 H 17 N 3 O 3" xref: MassAvg: "287.32" xref: MassMono: "287.126991" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00907 ! modified L-glutamine residue [Term] id: MOD:01776 name: S-methylthiocarbonylaminoethylcysteine (Cys) def: "A protein modification that effectively converts an L-cysteine residue to S-methylthiocarbonylaminoethylcysteine." [PubMed:18688235, PubMed:20608637] comment: This modified residue is a chemical analog of N6-acetyl-L-lysine produced from L-cysteine by methylthiocarbonylaziridine (MTCA, S-methyl aziridine-1-carbothioate). synonym: "(2R)-2-amino-3-([2-([(methylsulfanyl)carbonyl]amino)ethyl]sulfanyl)propanoic acid" EXACT PSI-MOD-alternate [] synonym: "L-cysteine N-(methylthiocarbonyl)aziridine adduct" EXACT PSI-MOD-alternate [] synonym: "MTCTK" EXACT PSI-MOD-alternate [] synonym: "N6-methylthiocarbonyl-4-thialysine" EXACT PSI-MOD-alternate [] synonym: "S-[2-([(methylthio)carbonyl]amino)ethyl]-L-cysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "117.17" xref: DiffFormula: "C 4 H 7 N 1 O 1 S 1" xref: DiffMono: "117.024835" xref: Formula: "C 7 H 12 N 2 O 2 S 2" xref: MassAvg: "220.31" xref: MassMono: "220.034020" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01777 name: S-(glycyl)-L-cysteine (Gly) def: "A protein modification that effectively converts a C-terminal glycine residue to S-(glycyl)-L-cysteine by forming a thioester bond with a free L-cysteine." [ChEBI:22050, PubMed:17726030, PubMed:18359941, PubMed:18771296, PubMed:18799456, PubMed:18842002, PubMed:3306404, RESID:AA0206] comment: This is not the cross-linking of two peptides, but the modification of a C-terminal glycine by formation of an thioester bond with a free cysteine. For the cross-linking of two peptide see MOD:00211 [JSG]. synonym: "(2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid" EXACT RESID-systematic [] synonym: "1-(cystein-S-yl)-glycinate" EXACT RESID-alternate [] synonym: "glycine cysteine thioester" EXACT RESID-alternate [] synonym: "MOD_RES CysO-cysteine adduct" EXACT UniProt-feature [] synonym: "S-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate [] synonym: "S-(glycyl)-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "103.14" xref: DiffFormula: "C 3 H 5 N 1 O 1 S 1" xref: DiffMono: "103.009185" xref: Formula: "C 5 H 9 N 2 O 3 S 1" xref: MassAvg: "177.20" xref: MassMono: "177.033388" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:01778 name: N-(glycyl)-L-cysteine def: "A protein modification that effectively converts a C-terminal glycine residue to N-(glycyl)-L-cysteine by forming a peptide bond with a free L-cysteine." [PubMed:18771296, PubMed:18799456, PubMed:18842002, RESID:AA0529] synonym: "(2R)-2-[(aminoacetyl)amino]-3-sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES CysO-cysteine adduct" EXACT UniProt-feature [] synonym: "N-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate [] synonym: "N-(glycyl)-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "103.14" xref: DiffFormula: "C 3 H 5 N 1 O 1 S 1" xref: DiffMono: "103.009185" xref: Formula: "C 5 H 9 N 2 O 3 S 1" xref: MassAvg: "177.20" xref: MassMono: "177.033388" xref: Origin: "G" xref: Source: "hypothetical" xref: TermSpec: "C-term" is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:01779 name: N6-(L-lysyl)-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-(L-lysyl)-L-lysine by formation of an isopeptide bond between the carboxyl group of a free lysine and the N6-amino group of the peptidyl L-lysine." [PubMed:18201202, PubMed:20729861, RESID:AA0530] comment: This is not the cross-linking of two peptides, but the modification of a peptidyl lysine by formation of an isopeptide bond with a free lysine [JSG]. synonym: "(2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "N6-(alpha-lysyl)-lysine" EXACT RESID-alternate [] synonym: "N6-(L-lysyl)-L-lysine" EXACT RESID-name [] xref: DiffAvg: "128.18" xref: DiffFormula: "C 6 H 12 N 2 O 1" xref: DiffMono: "128.094963" xref: Formula: "C 12 H 24 N 4 O 2" xref: MassAvg: "256.35" xref: MassMono: "256.189926" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01780 name: N6-(beta-lysyl)-L-5-hydroxylysine def: "A protein modification that effectively converts an L-lysine residue to N6-(beta-lysyl)-L-5-hydroxylysine by formation of an isopeptide bond between the carboxyl group of a free beta-lysine and the N6-amino group of a peptidyl L-lysine." [PubMed:18201202, PubMed:20729861, RESID:AA0531] synonym: "(2S)-2-amino-6-([(3R)-3,6-diaminohexanoyl]amino)-5-hydroxyhexanoic acid" EXACT RESID-systematic [] synonym: "5-hydroxy-N6-(beta-lysyl)-L-lysine" EXACT RESID-name [] synonym: "5-hydroxy-N6-[(3R)-beta-lysyl]lysine" EXACT RESID-alternate [] synonym: "EF-P lysine derivative" EXACT RESID-alternate [] synonym: "lysyl spermidine derivative [misidentification]" EXACT RESID-alternate [] synonym: "MOD_RES N6-(3,6-diaminohexanoyl)-5-hydroxylysine" EXACT UniProt-feature [] synonym: "N6-[(3R)-3,6-diaminohexanoyl]-L-5-hydroxylysine" EXACT RESID-alternate [] xref: DiffAvg: "144.17" xref: DiffFormula: "C 6 H 12 N 2 O 2" xref: DiffMono: "144.089878" xref: Formula: "C 12 H 24 N 4 O 3" xref: MassAvg: "272.35" xref: MassMono: "272.184841" xref: Origin: "K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00037 ! 5-hydroxy-L-lysine is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01781 name: N6-butanoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-butanoyl-L-lysine." [PubMed:17267393, PubMed:20715035, RESID:AA0532, UniMod:1289] comment: The binding of histone peptides with butanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. synonym: "(2S)-2-amino-6-(butanoylamino)hexanoic acid" EXACT RESID-systematic [] synonym: "(2S)-2-azanyl-6-(butanoylamino)hexanoic acid" EXACT RESID-alternate [] synonym: "2-amino-6-butyrylaminocaproic acid" EXACT RESID-alternate [] synonym: "epsilon-butanoyl-L-lysine" EXACT RESID-alternate [] synonym: "epsilon-butyryl-L-lysine" EXACT RESID-alternate [] synonym: "N(zeta)-butanoyllysine" EXACT RESID-alternate [] synonym: "N6-(1-oxobutyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-butanoyl-L-lysine" EXACT RESID-name [] synonym: "N6-butyryllysine" EXACT RESID-alternate [] xref: DiffAvg: "70.09" xref: DiffFormula: "C 4 H 6 N 0 O 1" xref: DiffMono: "70.041865" xref: Formula: "C 10 H 18 N 2 O 2" xref: MassAvg: "198.27" xref: MassMono: "198.136828" xref: Origin: "K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01875 ! N6-acylated L-lysine is_a: MOD:01997 ! N-butanoylated residue [Term] id: MOD:01782 name: N-methyl-L-serine def: "A protein modification that effectively converts an L-serine residue to N-methyl-L-serine." [PubMed:20668449, RESID:AA0533] subset: PSI-MOD-slim synonym: "(2S)-3-hydroxy-2-(methylamino)propanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES N-methylserine" EXACT UniProt-feature [] synonym: "N-methyl-L-serine" EXACT RESID-name [] synonym: "N-methylserine" EXACT RESID-alternate [] xref: DiffAvg: "14.03" xref: DiffFormula: "C 1 H 2 N 0 O 0" xref: DiffMono: "14.015650" xref: Formula: "C 4 H 7 N 1 O 2" xref: MassAvg: "101.10" xref: MassMono: "101.047678" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01680 ! alpha-amino monomethylated residue is_a: MOD:01800 ! N-methylated serine [Term] id: MOD:01783 name: N,N-dimethyl-L-serine def: "A protein modification that effectively converts an L-serine residue to N,N-dimethyl-L-serine." [PubMed:20668449, RESID:AA0534] synonym: "(2S)-2-(dimethylamino)propanoic acid" EXACT RESID-systematic [] synonym: "MOD_RES N,N-dimethylserine" EXACT UniProt-feature [] synonym: "N,N-dimethyl-L-serine" EXACT RESID-name [] synonym: "N,N-dimethylserine" EXACT RESID-alternate [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 5 H 10 N 1 O 2" xref: MassAvg: "116.14" xref: MassMono: "116.071154" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01686 ! alpha-amino dimethylated residue is_a: MOD:01800 ! N-methylated serine [Term] id: MOD:01784 name: N,N,N-trimethyl-L-serine def: "A protein modification that effectively converts an L-serine residue to N,N,N-trimethyl-L-serine." [PubMed:20668449, PubMed:3979397, RESID:AA0535] subset: PSI-MOD-slim synonym: "(1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanaminium" EXACT RESID-systematic [] synonym: "(1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanazanium" EXACT RESID-alternate [] synonym: "(2S)-2-trimethylammonio-3-hydroxypropanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N,N,N-trimethylserine" EXACT UniProt-feature [] synonym: "N,N,N-trimethyl-L-serine" EXACT RESID-name [] synonym: "N,N,N-trimethylserine cation" EXACT RESID-alternate [] synonym: "N,N,N-trimethylserinium" EXACT RESID-alternate [] xref: DiffAvg: "43.09" xref: DiffFormula: "C 3 H 7 N 0 O 0" xref: DiffMono: "43.054227" xref: FormalCharge: "1+" xref: Formula: "C 6 H 13 N 1 O 2" xref: MassAvg: "131.17" xref: MassMono: "131.094080" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue is_a: MOD:01800 ! N-methylated serine [Term] id: MOD:01785 name: O-(L-isoglutamyl)-L-threonine (active site intermediate) def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia." [PubMed:8706862, RESID:AA0536#THR] comment: This is not an ester cross-link of peptides [JSG]. synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate [] synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate [] synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate [] synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate [] xref: DiffAvg: "129.12" xref: DiffFormula: "C 5 H 7 N 1 O 3" xref: DiffMono: "129.042593" xref: Formula: "C 9 H 14 N 2 O 5" xref: MassAvg: "230.22" xref: MassMono: "230.090272" xref: Origin: "T" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00671 ! O-acylated residue is_a: MOD:01979 ! O-(L-isoglutamyl)-L-threonine [Term] id: MOD:01786 name: 3'-nitro-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to 3'-nitro-L-tyrosine." [ChEBI:44454, PubMed:16944230, PubMed:5339594, RESID:AA0537] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid" EXACT RESID-systematic [] synonym: "3'-nitro-L-tyrosine" EXACT RESID-name [] synonym: "3-nitro-L-tyrosine" EXACT RESID-alternate [] synonym: "3-nitrotyrosine" EXACT RESID-alternate [] synonym: "m-nitrotyrosine" EXACT RESID-alternate [] synonym: "meta-nitrotyrosine" EXACT RESID-alternate [] synonym: "MOD_RES 3'-Nitrotyrosine" EXACT UniProt-feature [] xref: DiffAvg: "45.00" xref: DiffFormula: "C 0 H -1 N 1 O 2" xref: DiffMono: "44.985078" xref: Formula: "C 9 H 8 N 2 O 4" xref: MassAvg: "208.17" xref: MassMono: "208.048407" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01352 ! nitrated L-tyrosine [Term] id: MOD:01787 name: 5'-(L-tyros-5'-yl)amino-L-tyrosine def: "A protein modification that effectively cross-links two L-tyrosine residues through their 5' positions by amine nitrogen to form 5'-(L-tyros-5'-yl)amino-L-tyrosine." [PubMed:18781570, RESID:AA0459] comment: Cross-link 2. synonym: "(2S,2'S)-3,3'-[iminobis(4-hydroxybenzene-3,1-diyl)]bis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "5'-(L-tyros-5'-yl)amino-L-tyrosine" EXACT RESID-name [] synonym: "5'-[(tyros-5'-yl)amino]tyrosine" EXACT RESID-alternate [] synonym: "5'-tyrosyl-5'-aminotyrosine" EXACT RESID-alternate [] synonym: "bis(LTQ) linkage" EXACT RESID-alternate [] synonym: "CROSSLNK 5'-tyrosyl-5'-aminotyrosine (Tyr-Tyr) (interchain)" EXACT UniProt-feature [] xref: DiffAvg: "13.00" xref: DiffFormula: "C 0 H -1 N 1 O 0" xref: DiffMono: "12.995249" xref: Formula: "C 18 H 17 N 3 O 4" xref: MassAvg: "339.35" xref: MassMono: "339.121906" xref: Origin: "Y, Y" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01788 name: histidine immonium ion def: "A protein modification that effectively converts an N-terminal L-histidine residue to histidine immonium ion." [PubMed:17074506, PubMed:18688235] comment: This fragment corresponds to the first ion in an a+ series. subset: PSI-MOD-slim synonym: "2-(1H-imidazolyl)ethaniminium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-27.00" xref: DiffFormula: "C -1 H 1 N 0 O -1" xref: DiffMono: "-26.987638" xref: FormalCharge: "1+" xref: Formula: "C 5 H 8 N 3 O 0" xref: MassAvg: "110.14" xref: MassMono: "110.071274" xref: Origin: "H" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01527 ! residue reporter fragment [Term] id: MOD:01789 name: phenylalanine immonium ion def: "A protein modification that effectively converts an N-terminal L-phenylalanine residue to phenylalanine immonium ion." [PubMed:17074506, PubMed:18688235] comment: This fragment corresponds to the first ion in an a+ series. subset: PSI-MOD-slim synonym: "2-phenylethaniminium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-27.00" xref: DiffFormula: "C -1 H 1 N 0 O -1" xref: DiffMono: "-26.987638" xref: FormalCharge: "1+" xref: Formula: "C 8 H 10 N 1 O 0" xref: MassAvg: "120.17" xref: MassMono: "120.080776" xref: Origin: "F" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:01527 ! residue reporter fragment [Term] id: MOD:01790 name: tyrosine immonium ion def: "A protein modification that effectively converts an an N-terminal L-tyrosine residue to tyrosine immonium ion." [PubMed:17074506, PubMed:18688235] comment: This fragment corresponds to the first ion in an a+ series. subset: PSI-MOD-slim synonym: "2-(4-hydroxyphenyl)ethaniminium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-27.00" xref: DiffFormula: "C -1 H 1 N 0 O -1" xref: DiffMono: "-26.987638" xref: FormalCharge: "1+" xref: Formula: "C 8 H 10 N 1 O 1" xref: MassAvg: "136.17" xref: MassMono: "136.075690" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01527 ! residue reporter fragment [Term] id: MOD:01791 name: phosphohistidine immonium ion def: "A protein modification that effectively converts an N-terminal phosphohistidine residue to phosphohistidine immonium ion." [PubMed:17690871, PubMed:18688235, PubMed:20847263] comment: This fragment corresponds to the first ion in an a+ series. subset: PSI-MOD-slim synonym: "2-(1H-imidazolyl)ethaniminium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-27.00" xref: DiffFormula: "C -1 H 1 N 0 O -1" xref: DiffMono: "-26.987638" xref: FormalCharge: "1+" xref: Formula: "C 5 H 9 N 3 O 3 P 1" xref: MassAvg: "190.12" xref: MassMono: "190.037604" xref: Origin: "MOD:00890" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01527 ! residue reporter fragment relationship: derives_from MOD:00890 ! phosphorylated L-histidine [Term] id: MOD:01792 name: phosphotyrosine immonium ion def: "A protein modification that effectively converts an N-terminal O4'-phospho-L-tyrosine residue to tyrosine immonium ion." [PubMed:17690871, PubMed:18688235] comment: This fragment corresponds to the first ion in an a+ series. subset: PSI-MOD-slim synonym: "2-(4-phosphonoxyphenyl)ethaniminium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-27.00" xref: DiffFormula: "C -1 H 1 N 0 O -1" xref: DiffMono: "-26.987638" xref: FormalCharge: "1+" xref: Formula: "C 8 H 11 N 1 O 4 P 1" xref: MassAvg: "216.15" xref: MassMono: "216.042021" xref: Origin: "MOD:00048" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01527 ! residue reporter fragment relationship: derives_from MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: MOD:01793 name: S-carboxamidomethyl-L-cysteine sulfoxide def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfoxide." [PubMed:11212008, PubMed:17689096, PubMed:18306178, PubMed:18688235] synonym: "CamCO" EXACT PSI-MOD-alternate [] synonym: "S-carbamoylmethyl-L-cysteine sulfoxide" EXACT PSI-MOD-alternate [] xref: DiffAvg: "73.05" xref: DiffFormula: "C 2 H 3 N 1 O 2" xref: DiffMono: "73.016378" xref: Formula: "C 5 H 8 N 2 O 3 S 1" xref: MassAvg: "176.19" xref: MassMono: "176.025563" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00708 ! sulfur oxygenated L-cysteine is_a: MOD:01854 ! sulfur monooxygenated residue relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine [Term] id: MOD:01794 name: 1x(13)C,3x(2)H labeled monomethylated residue def: "A protein modification that effectively replaces the methyl group of a residue containing common isotopes with a 1x(13)C,3x(2)H labeled monomethylated residue." [PubMed:18688235] synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label [] xref: DiffAvg: "18.04" xref: DiffFormula: "(13)C 1 (1)H -1 (2)H 3" xref: DiffMono: "18.037835" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00839 ! (2)H deuterium labeled residue is_a: MOD:00842 ! (13)C labeled residue [Term] id: MOD:01795 name: 1x(13)C,3x(2)H C(6)-labeled L-methionine def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine." [PubMed:15782174, PubMed:18688235] synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label [] xref: DiffAvg: "4.02" xref: DiffFormula: "(12)C -1 (13)C 1 (1)H -3 (2)H 3" xref: DiffMono: "4.022185" xref: Formula: "(12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 1 S 1" xref: MassAvg: "135.06" xref: MassMono: "135.062670" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00839 ! (2)H deuterium labeled residue is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01794 ! 1x(13)C,3x(2)H labeled monomethylated residue [Term] id: MOD:01796 name: 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide." [PubMed:15782174, PubMed:18688235] xref: DiffAvg: "20.02" xref: DiffFormula: "(12)C -1 (13)C 1 (1)H -3 (2)H 3 O 1" xref: DiffMono: "20.017100" xref: Formula: "(12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 2 S 1" xref: MassAvg: "151.06" xref: MassMono: "151.057585" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00839 ! (2)H deuterium labeled residue is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01794 ! 1x(13)C,3x(2)H labeled monomethylated residue [Term] id: MOD:01797 name: 1'-phosphohistidine immonium ion def: "A protein modification that effectively converts an N-terminal 1'-phosphohistidine residue to 1'-phosphohistidine immonium ion." [PubMed:17690871, PubMed:18688235, PubMed:20847263] comment: This fragment corresponds to the first ion in an a+ series. synonym: "2-((1-phosphono-1H-imidazol-4-yl)ethaniminium" EXACT PSI-MOD-alternate [] synonym: "Ntau-phosphorylated L-histidine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-27.00" xref: DiffFormula: "C -1 H 1 N 0 O -1" xref: DiffMono: "-26.987638" xref: FormalCharge: "1+" xref: Formula: "C 5 H 9 N 3 O 3 P 1" xref: MassAvg: "190.12" xref: MassMono: "190.037604" xref: Origin: "MOD:00044" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01791 ! phosphohistidine immonium ion relationship: derives_from MOD:00044 ! 1'-phospho-L-histidine [Term] id: MOD:01798 name: 3'-phosphohistidine immonium ion def: "A protein modification that effectively converts an N-terminal 3'-phosphohistidine residue to 3'-phosphohistidine immonium ion." [PubMed:18688235] comment: This fragment corresponds to the first ion in an a+ series. synonym: "2-(1-phosphono-1H-imidazol-5-yl)ethaniminium" EXACT PSI-MOD-alternate [] synonym: "Npi-phosphorylated L-histidine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-27.00" xref: DiffFormula: "C -1 H 1 N 0 O -1" xref: DiffMono: "-26.987638" xref: FormalCharge: "1+" xref: Formula: "C 5 H 9 N 3 O 3 P 1" xref: MassAvg: "190.12" xref: MassMono: "190.037604" xref: Origin: "MOD:00045" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01791 ! phosphohistidine immonium ion relationship: derives_from MOD:00045 ! 3'-phospho-L-histidine [Term] id: MOD:01799 name: methylated serine def: "A protein modification that effectively converts an L-alanine residue to a methylated serine, such as N-methylserine, N,N-dimethylserine, or N,N,N-trimethylserine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeSer" EXACT PSI-MOD-label [] xref: Origin: "S" is_a: MOD:00427 ! methylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01800 name: N-methylated serine def: "A protein modification that effectively replaces an L-serine alpha amino hydrogen with a methyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01460 ! alpha-amino methylated residue is_a: MOD:01799 ! methylated serine [Term] id: MOD:01801 name: protonated L-serine (L-serinium) residue def: "A protein modification that effectively converts an L-serine residue to an L-serinium (protonated L-serine)." [PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "1.01" xref: DiffFormula: "C 0 H 1 N 0 O 0" xref: DiffMono: "1.007276" xref: FormalCharge: "1+" xref: Formula: "C 3 H 7 N 1 O 2" xref: MassAvg: "89.09" xref: MassMono: "89.047130" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01700 ! alpha-amino protonated residue [Term] id: MOD:01802 name: N,N,N-trimethyl-L-serine (from L-serinium) def: "A protein modification that effectively converts an L-serinium (protonated L-serine) residue to an N,N,N-trimethyl-L-serine." [PubMed:18688235] comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ser process (MOD:00071) accounts for both protonation and trimethylation. subset: PSI-MOD-slim synonym: "N2Me3Ala" EXACT PSI-MOD-label [] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6 N 0 O 0" xref: DiffMono: "42.046402" xref: FormalCharge: "1+" xref: Formula: "C 6 H 13 N 1 O 2" xref: MassAvg: "131.17" xref: MassMono: "131.094080" xref: Origin: "MOD:01801" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01687 ! alpha-amino trimethylated residue relationship: derives_from MOD:01801 ! protonated L-serine (L-serinium) residue [Term] id: MOD:01803 name: O-methylated threonine def: "A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine or L-threonine methyl ester." [PubMed:18688235] synonym: "OMeThr" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00393 ! O-methylated residue is_a: MOD:01418 ! methylated threonine [Term] id: MOD:01804 name: glycosylphosphorylated residue def: "A protein modification that effectively results from forming an adduct with a glycosylphosphate through a phosphodiester bond." [PubMed:18688235] is_a: MOD:00764 ! glycoconjugated residue is_a: MOD:00861 ! phosphorus containing modified residue [Term] id: MOD:01805 name: N-(L-isoaspartyl)-glycine (Asp) def: "A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)-glycine and the release of water." [ChEBI:21479, PubMed:1826288, PubMed:18671394, RESID:AA0126] comment: Cross-link 2. synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Asp-Gly)" EXACT UniProt-feature [] synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asp)" EXACT UniProt-feature [] synonym: "isoaspartyl glycine" EXACT RESID-alternate [] synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name [] synonym: "N-beta-aspartylglycine" EXACT RESID-alternate [] synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 7 N 2 O 3" xref: MassAvg: "155.13" xref: MassMono: "155.045667" xref: Origin: "D, G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01928 ! N-(L-isoaspartyl)-glycine [Term] id: MOD:01806 name: N,N-dimethyl-L-leucine def: "A protein modification that effectively converts an L-leucine residue to N,N-dimethyl-L-leucine." [PubMed:19522542, RESID:AA0538] synonym: "(2S)-2-(dimethylamino)-4-methylpentanoic acid" EXACT RESID-systematic [] synonym: "2-(dimethylamino)-4-methylvaleric acid" EXACT RESID-alternate [] synonym: "2-(dimethylazanyl)-4-methylpentanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N,N-dimethylleucine" EXACT UniProt-feature [] synonym: "N,N-dimethyl-L-leucine" EXACT RESID-name [] synonym: "N,N-dimethylleucine" EXACT RESID-alternate [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 16 N 1 O 1" xref: MassAvg: "142.22" xref: MassMono: "142.123189" xref: Origin: "L" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:01686 ! alpha-amino dimethylated residue is_a: MOD:01808 ! N-methylated leucine [Term] id: MOD:01807 name: N-formyl-L-glutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to N-formyl-L-glutamic acid." [PubMed:18001127, RESID:AA0539] synonym: "(2S)-2-(formylamino)pentanedioic acid" EXACT RESID-systematic [] synonym: "2-(formylazanyl)pentanedioic acid" EXACT RESID-alternate [] synonym: "2-formamidopentanedioic acid" EXACT RESID-alternate [] synonym: "2-formylaminopentanedioic acid" EXACT RESID-alternate [] synonym: "N-formyl-L-glutamic acid" EXACT RESID-name [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 6 H 8 N 1 O 4" xref: MassAvg: "158.13" xref: MassMono: "158.045333" xref: Origin: "E" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00409 ! N-formylated residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01808 name: N-methylated leucine def: "A protein modification that effectively replaces an L-leucine alpha amino hydrogen with a methyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "MeLeu" EXACT PSI-MOD-label [] xref: Origin: "L" is_a: MOD:00662 ! methylated leucine is_a: MOD:01460 ! alpha-amino methylated residue [Term] id: MOD:01809 name: 5x(13)C,1x(15)N labeled residue def: "A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C,1x(15)N labeled residue." [PubMed:12771378, UniMod:268] synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "6.01" xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" xref: DiffMono: "6.013809" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00842 ! (13)C labeled residue is_a: MOD:00843 ! (15)N labeled residue [Term] id: MOD:01810 name: 5x(13)C,1x(15)N labeled L-proline def: "A protein modification that effectively converts an L-proline residue to 5x(13)C,1x(15)N labeled L-proline." [PubMed:12771378, UniMod:268#P] synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "6.01" xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" xref: DiffMono: "6.013809" xref: Formula: "(13)C 5 H 7 (15)N 1 O 1" xref: MassAvg: "103.07" xref: MassMono: "103.066573" xref: Origin: "P" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue [Term] id: MOD:01811 name: 5x(13)C,1x(15)N labeled L-methionine def: "A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine." [PubMed:12771378, UniMod:268#M] synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "6.01" xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" xref: DiffMono: "6.013809" xref: Formula: "(13)C 5 H 9 (15)N 1 O 1 S 1" xref: MassAvg: "137.05" xref: MassMono: "137.054294" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue [Term] id: MOD:01812 name: 5x(13)C,1x(15)N labeled L-methionine sulfoxide def: "A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine sulfoxide." [PubMed:12771378, UniMod:268#M] synonym: "13C(5) 15N(1) Silac label" RELATED UniMod-description [] synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label [] xref: DiffAvg: "6.01" xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1" xref: DiffMono: "6.013809" xref: Formula: "(13)C 5 H 9 (15)N 1 O 2 S 1" xref: MassAvg: "153.05" xref: MassMono: "153.049209" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00719 ! L-methionine sulfoxide is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue [Term] id: MOD:01813 name: morpholine-2-acetylated residue def: "A protein modification that effectively substitutes a morpholine-2-acetyl group for a hydrogen atom." [PubMed:10446193, UniMod:29] comment: The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. synonym: "N-Succinimidyl-2-morpholine acetate" RELATED UniMod-description [] synonym: "N-succinimidylmorpholine-2-acetate derivative" EXACT PSI-MOD-alternate [] synonym: "SMA" RELATED PSI-MS-label [] xref: DiffAvg: "127.14" xref: DiffFormula: "C 6 H 9 N 1 O 2" xref: DiffMono: "127.063329" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" is_a: MOD:00649 ! acylated residue is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01814 name: L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid def: "A protein modification that effectively cross-links a cysteine and two serine residues to form L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid." [PubMed:18406324, PubMed:19678698, PubMed:893891, RESID:AA0540] comment: Cross-link 3. synonym: "6-[(1R)-1-amino-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid" EXACT RESID-systematic [] synonym: "6-[1-azanyl-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid" EXACT RESID-alternate [] synonym: "L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-54.07" xref: DiffFormula: "C 0 H -8 N -1 O -2 S 0" xref: DiffMono: "-54.055504" xref: Formula: "C 9 H 7 N 2 O 3 S 1" xref: MassAvg: "223.23" xref: MassMono: "223.017738" xref: Origin: "C, S, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01425 ! pyridinyl ring crosslinked residues [Term] id: MOD:01815 name: L-glutamate thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamic acid residue to form L-glutamate thiazole-4-carboxylic acid." [PubMed:18406324, PubMed:19678698, PubMed:893891, RESID:AA0541] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[-1-azanyl-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Glu-Cys)" EXACT UniProt-feature [] synonym: "L-glutamate thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 8 H 8 N 2 O 3 S 1" xref: MassAvg: "212.22" xref: MassMono: "212.025563" xref: Origin: "C, E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01816 name: 2'-hydroxy-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to a 2'-hydroxy-L-tryptophan." [PubMed:11714714, RESID:AA0542] synonym: "(2S)-2-amino-3-(2-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "2'-hydroxy-L-tryptophan" EXACT RESID-name [] synonym: "2-azanyl-3-(2-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-alternate [] synonym: "2-hydroxy-L-tryptophan" EXACT RESID-alternate [] synonym: "2-hydroxy-tryptophan" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 11 H 10 N 2 O 2" xref: MassAvg: "202.21" xref: MassMono: "202.074228" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01622 ! monohydroxylated tryptophan [Term] id: MOD:01817 name: oxidation of tryptophan to 2'-oxo-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to a 2'-oxo-L-tryptophan." [PubMed:9461080, RESID:AA0543] synonym: "(2S)-2-amino-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid" EXACT RESID-systematic [] synonym: "2'-oxo-L-tryptophan" EXACT RESID-name [] synonym: "2-azanyl-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate [] synonym: "2-oxo-L-tryptophan" EXACT RESID-alternate [] synonym: "2-oxotryptophan" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 11 H 10 N 2 O 2" xref: MassAvg: "202.21" xref: MassMono: "202.074228" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01818 name: 1'-(L-tryptophan-3'-yl)-L-tryptophan def: "A protein modification that effectively cross-links two tryptophan residues to form 1'-(L-tryptophan-3'-yl)-L-tryptophan." [PubMed:20600836, RESID:AA0544] comment: Cross-link 2. synonym: "(2S,2'S)-3,3'-(3'H-1,3'-biindole-3,3'-diyl)bis(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "1-(L-tryptophan-3-yl)-L-tryptophan" EXACT RESID-name [] synonym: "2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate [] synonym: "3-[(2S)-2-amino-2-carboxyethyl]-3-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-1H-indole" EXACT RESID-systematic [] synonym: "3-[2-azanyl-2-carboxyethyl]-3-(3-[2-azanyl-2-carboxyethyl]-1H-indol-2-yl)-1H-indole" EXACT RESID-alternate [] synonym: "ditryptophan" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 22 H 18 N 4 O 2" xref: MassAvg: "370.41" xref: MassMono: "370.142976" xref: Origin: "W, W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00918 ! modified L-tryptophan residue [Term] id: MOD:01819 name: N6-succinyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-succinyl-L-lysine." [PubMed:16582421, PubMed:21151122, RESID:AA0545] subset: PSI-MOD-slim synonym: "(2S)-2-amino-6-[(3-carboxypropanoyl)amino]hexanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-6-[(3-carboxypropanoyl)azanyl]hexanoic acid" EXACT RESID-alternate [] synonym: "4-[[(5S)-5-amino-6-hydroxy-6-oxohexyl]amino]-4-oxobutanoate" EXACT RESID-alternate [] synonym: "MOD_RES N6-succinyllysine" EXACT UniProt-feature [] synonym: "N(epsilon)-(succinyl)lysine" EXACT RESID-alternate [] synonym: "N6-succinyl-L-lysine" EXACT RESID-name [] synonym: "succinyllysine" EXACT RESID-alternate [] xref: DiffAvg: "100.07" xref: DiffFormula: "C 4 H 4 N 0 O 3" xref: DiffMono: "100.016044" xref: Formula: "C 10 H 16 N 2 O 4" xref: MassAvg: "228.25" xref: MassMono: "228.111007" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01029 ! succinylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01820 name: isotope tagged sufhydryl reagent modified cysteine def: "A protein modification that effectively replaces a cysteine sulhydryl hydrogen with an isotope tagged sulfhydryl reagent group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01821 name: cysTMT6plex reporter+balance reagent cysteine disulfide def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex reporter+balance group." [UniMod:985, URL:http\://www.piercenet.com/files/2162220.pdf] comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "cysTMT6plex" RELATED UniMod-interim [] synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01429 ! (15)N isotope tagged reagent is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine [Term] id: MOD:01822 name: cysTMT6plex-zero reporter+balance reagent cysteine disulfide def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-zero reporter+balance group." [UniMod:984, URL:http\://www.piercenet.com/files/2162220.pdf] comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "cysTMT" RELATED UniMod-interim [] synonym: "Native cysteine-reactive Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "299.17" xref: DiffFormula: "(12)C 14 H 25 (14)N 3 O 2 S 1" xref: DiffMono: "299.166748" xref: Formula: "(12)C 17 H 32 (14)N 4 O 4 S 2" xref: MassAvg: "420.19" xref: MassMono: "420.186498" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide [Term] id: MOD:01823 name: cysTMT6plex-126 reporter+balance reagent cysteine disulfide def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-126 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "cysTMT6plex" RELATED UniMod-interim [] synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.18" xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" xref: DiffMono: "304.177202" xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" xref: MassAvg: "425.20" xref: MassMono: "425.196952" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide [Term] id: MOD:01824 name: cysTMT6plex-127 reporter+balance reagent cysteine disulfide def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-127 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "cysTMT6plex" RELATED UniMod-interim [] synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.18" xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" xref: DiffMono: "304.177202" xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" xref: MassAvg: "425.20" xref: MassMono: "425.196952" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide [Term] id: MOD:01825 name: cysTMT6plex-128 reporter+balance reagent cysteine disulfide def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-128 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "cysTMT6plex" RELATED UniMod-interim [] synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.18" xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" xref: DiffMono: "304.177202" xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" xref: MassAvg: "425.20" xref: MassMono: "425.196952" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide [Term] id: MOD:01826 name: cysTMT6plex-129 reporter+balance reagent cysteine disulfide def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-129 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "cysTMT6plex" RELATED UniMod-interim [] synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.18" xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" xref: DiffMono: "304.177202" xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" xref: MassAvg: "425.20" xref: MassMono: "425.196952" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide [Term] id: MOD:01827 name: cysTMT6plex-130 reporter+balance reagent cysteine disulfide def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-130 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "cysTMT6plex" RELATED UniMod-interim [] synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.18" xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" xref: DiffMono: "304.177202" xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" xref: MassAvg: "425.20" xref: MassMono: "425.196952" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide [Term] id: MOD:01828 name: cysTMT6plex-131 reporter+balance reagent cysteine disulfide def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-131 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf] comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED UniMod-description [] synonym: "cysTMT6plex" RELATED UniMod-interim [] synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate [] xref: DiffAvg: "304.18" xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1" xref: DiffMono: "304.177202" xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2" xref: MassAvg: "425.20" xref: MassMono: "425.196952" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide [Term] id: MOD:01829 name: S-carboxymethyl-L-cysteine sulfoxide def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfoxide." [PubMed:17689096, PubMed:18688235] synonym: "CmCO" EXACT PSI-MOD-alternate [] xref: DiffAvg: "58.04" xref: DiffFormula: "C 2 H 2 N 0 O 2 S 0" xref: DiffMono: "58.005479" xref: Formula: "C 5 H 7 N 1 O 3 S 1" xref: MassAvg: "161.18" xref: MassMono: "161.014664" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00399 ! iodoacetic acid derivatized residue is_a: MOD:00708 ! sulfur oxygenated L-cysteine is_a: MOD:01854 ! sulfur monooxygenated residue relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine [Term] id: MOD:01830 name: S-carboxymethyl-L-cysteine sulfone def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfone." [PubMed:18688235] synonym: "CmCO2" EXACT PSI-MOD-label [] xref: DiffAvg: "74.03" xref: DiffFormula: "C 2 H 2 N 0 O 3 S 0" xref: DiffMono: "74.000394" xref: Formula: "C 5 H 7 N 1 O 4 S 1" xref: MassAvg: "177.17" xref: MassMono: "177.009579" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00399 ! iodoacetic acid derivatized residue is_a: MOD:00708 ! sulfur oxygenated L-cysteine is_a: MOD:01855 ! sulfur dioxygenated residue relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine [Term] id: MOD:01831 name: S-carboxamidomethyl-L-cysteine sulfone def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfone." [PubMed:18688235] synonym: "CamCO2" EXACT PSI-MOD-label [] synonym: "S-carbamoylmethyl-L-cysteine sulfone" EXACT PSI-MOD-alternate [] xref: DiffAvg: "89.05" xref: DiffFormula: "C 2 H 3 N 1 O 3" xref: DiffMono: "89.011293" xref: Formula: "C 5 H 8 N 2 O 4 S 1" xref: MassAvg: "192.19" xref: MassMono: "192.020478" xref: Origin: "C" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00708 ! sulfur oxygenated L-cysteine is_a: MOD:01855 ! sulfur dioxygenated residue relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine [Term] id: MOD:01832 name: 5x(13)C-labeled residue def: "A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C-labeled residue." [PubMed:12771378, UniMod:772] synonym: "13C(5) Silac label" RELATED UniMod-description [] synonym: "Label:13C(5)" RELATED PSI-MS-label [] xref: DiffAvg: "5.02" xref: DiffFormula: "(12)C -5 (13)C 5" xref: DiffMono: "5.016774" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00842 ! (13)C labeled residue [Term] id: MOD:01833 name: 5x(13)C-labeled L-methionine def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine." [PubMed:18688235, url:] xref: DiffAvg: "5.02" xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 0 S 0" xref: DiffMono: "5.016774" xref: Formula: "(13)C 5 H 9 N 1 O 1 S 1" xref: MassAvg: "136.06" xref: MassMono: "136.057259" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01832 ! 5x(13)C-labeled residue [Term] id: MOD:01834 name: 5x(13)C-labeled L-methionine sulfoxide def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfoxide." [PubMed:18688235] xref: DiffAvg: "21.01" xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 1 S 0" xref: DiffMono: "21.011689" xref: Formula: "(13)C 5 H 9 N 1 O 2 S 1" xref: MassAvg: "152.05" xref: MassMono: "152.052174" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00719 ! L-methionine sulfoxide is_a: MOD:01832 ! 5x(13)C-labeled residue [Term] id: MOD:01835 name: 5x(13)C-labeled L-methionine sulfone def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfone." [PubMed:18688235] xref: DiffAvg: "37.01" xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 2 S 0" xref: DiffMono: "37.006603" xref: Formula: "(13)C 5 H 9 N 1 O 3 S 1" xref: MassAvg: "168.05" xref: MassMono: "168.047088" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00256 ! L-methionine sulfone is_a: MOD:01832 ! 5x(13)C-labeled residue [Term] id: MOD:01836 name: N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine def: "A protein modification that effectively converts an L-lysine residue to N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine." [PubMed:18688235, PubMed:20218600, PubMed:21271704] synonym: "(2S)-2-amino-6-[([1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]carbonyl)amino]hexanoic acid" EXACT PSI-MOD-alternate [] synonym: "[(alpha-methyl-6-nitro-piperonyloxy)carbonyl]lysine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "237.17" xref: DiffFormula: "C 10 H 7 N 1 O 6" xref: DiffMono: "237.027337" xref: Formula: "C 16 H 19 N 3 O 7" xref: MassAvg: "365.34" xref: MassMono: "365.122300" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00848 ! reagent derivatized residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01837 name: L-lanthionine (Cys-Cys) def: "A protein modification that effectively cross-links two L-cysteine residues with a thioether bond to form L-lanthionine." [ChEBI:21347, PubMed:20805503, PubMed:6007887, RESID:AA0110#CYS2] comment: Cross-link 2. synonym: "(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic [] synonym: "(R)-S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT RESID-alternate [] synonym: "(R,R)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate [] synonym: "(R,R)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate [] synonym: "(R,R)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate [] synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT RESID-alternate [] synonym: "3,3'-thiobis-L-alanine" EXACT RESID-alternate [] synonym: "L-lanthionine" EXACT RESID-name [] xref: DiffAvg: "-34.08" xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1" xref: DiffMono: "-33.987721" xref: Formula: "C 6 H 8 N 2 O 2 S 1" xref: MassAvg: "172.20" xref: MassMono: "172.030649" xref: Origin: "C, C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01839 ! L-lanthionine [Term] id: MOD:01838 name: L-lysinoalanine (Lys) def: "A protein modification that effectively converts an L-lysine residue to L-lysinoalanine." [PubMed:19155267, PubMed:2544544, RESID:AA0123#LYS] comment: This entry is for the modification of peptidyl lysine by a free serine. For the crosslink of peptidyl serine and peptidyl lysine see MOD:00132. synonym: "(2R,9S)-lysinoalanine" EXACT RESID-alternate [] synonym: "(2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "alaninolysine" EXACT RESID-alternate [] synonym: "L-lysinoalanine" EXACT RESID-name [] synonym: "LAL" EXACT RESID-alternate [] synonym: "lysino-D-alanine" EXACT RESID-alternate [] synonym: "MOD_RES Lysino-D-alanine (Lys)" EXACT UniProt-feature [] synonym: "N-epsilon-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate [] synonym: "N6-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate [] xref: DiffAvg: "87.08" xref: DiffFormula: "C 3 H 5 N 1 O 2" xref: DiffMono: "87.032028" xref: Formula: "C 9 H 17 N 3 O 3" xref: MassAvg: "215.25" xref: MassMono: "215.126991" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01853 ! L-lysinoalanine [Term] id: MOD:01839 name: L-lanthionine def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine." [PubMed:18688235] comment: Cross-link 2. For the natural form of the lanthionine cross-link see MOD:00120 meso-lanthionine [JSG]. xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 8 N 2 O 2 S 1" xref: MassAvg: "172.20" xref: MassMono: "172.030649" xref: Origin: "C, X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:01841 ! lanthionine [Term] id: MOD:01840 name: L-allo-isoleucine def: "A protein modification that effectively converts an L-isoleucine residue to L-allo-isoleucine." [ChEBI:43433, PubMed:20805503, RESID:AA0546] synonym: "(2S,3R)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate [] synonym: "3-methyl-norvaline" EXACT RESID-alternate [] synonym: "allo-L-isoleucine" EXACT RESID-alternate [] synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate [] synonym: "L-allo-isoleucine" EXACT RESID-name [] synonym: "L-threo-isoleucine" EXACT RESID-alternate [] synonym: "MOD_RES L-allo-isoleucine" EXACT UniProt-feature [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 6 H 11 N 1 O 1" xref: MassAvg: "113.16" xref: MassMono: "113.084064" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00910 ! modified L-isoleucine residue [Term] id: MOD:01841 name: lanthionine def: "A protein modification that effectively cross-links either two or an L-cysteine residue and an L-serine residue by a thioether bond to form a lanthionine, either D- or L- or meso-lanthionine." [PubMed:18688235] comment: Cross-link 2. [JSG]. synonym: "2,6-diamino-4-thiaheptanedioic acid" EXACT PSI-MOD-alternate [] synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT PSI-MOD-alternate [] synonym: "3,3'-thiobis-(2-aminopropanoic acid)" EXACT PSI-MOD-alternate [] synonym: "3,3'-thiobis-L-alanine" EXACT PSI-MOD-alternate [] synonym: "bis(2-amino-2-carboxyethyl)sulfanediyl" EXACT PSI-MOD-alternate [] synonym: "bis(2-amino-2-carboxyethyl)sulfide" EXACT PSI-MOD-alternate [] synonym: "S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 6 H 8 N 2 O 2 S 1" xref: MassAvg: "172.20" xref: MassMono: "172.030649" xref: Origin: "C, X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01993 ! beta-carbon thioether crosslinked residues [Term] id: MOD:01842 name: S-(2-aminovinyl)-L-cysteine def: "A protein modification that effectively converts two L-cysteine residues to S-(2-aminovinyl)-L-cysteine." [PubMed:20805503, RESID:AA0548] comment: Cross-link 2. synonym: "(2R)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "(R,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate [] synonym: "S-(2-aminovinyl)-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "-80.10" xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1" xref: DiffMono: "-79.993200" xref: Formula: "C 5 H 7 N 2 O 1 S 1" xref: MassAvg: "143.18" xref: MassMono: "143.027909" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01851 ! S-(2-aminovinyl)-cysteine [Term] id: MOD:01843 name: 5'-chloro-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to 5'-chloro-L-tryptophan." [PubMed:18215770, RESID:AA0549] synonym: "(2S)-2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic [] synonym: "5'-chloro-L-tryptophan" EXACT RESID-name [] synonym: "MOD_RES 5'-chlorotryptophan" EXACT UniProt-feature [] xref: DiffAvg: "34.44" xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" xref: DiffMono: "33.961028" xref: Formula: "C 11 Cl 1 H 9 N 2 O 1" xref: MassAvg: "220.66" xref: MassMono: "220.040341" xref: Origin: "W" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01913 ! monochlorinated L-tryptophan [Term] id: MOD:01844 name: 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid def: "A protein modification that effectively converts an L-cysteine residue and an L-leucine residue to 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0550] comment: Cross-link 2. synonym: "(4Z)-4-[hydroxy(sulfanyl)methylidene]-2-(3-methylbutanoyl)-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate [] synonym: "2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid" EXACT RESID-name [] synonym: "5-hydroxy-2-(3-methylbutanoyl)-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic [] synonym: "MOD_RES 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid (Leu-Cys)" EXACT UniProt-feature [] xref: DiffAvg: "-5.06" xref: DiffFormula: "C 0 H -7 N -1 O 1 S 0" xref: DiffMono: "-5.062935" xref: Formula: "C 9 H 10 N 1 O 3 S 1" xref: MassAvg: "212.24" xref: MassMono: "212.038139" xref: Origin: "C, L" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00911 ! modified L-leucine residue is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys) [Term] id: MOD:01845 name: L-proline 5-hydroxyoxazole-4-carbothionic acid def: "A protein modification that effectively converts an L-cysteine residue and an L-proline residue to L-proline 5-hydroxyoxazole-4-carbothionic acid." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0551] comment: Cross-link 2. synonym: "(4Z)-4-[hydroxy(sulfanyl)methylidene]-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate [] synonym: "5-hydroxy-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic [] synonym: "CROSSLNK Proline 5-hydroxy-oxazole-4-carbothionic acid (Pro-Cys)" EXACT UniProt-feature [] synonym: "L-proline 5-hydroxy-oxazole-4-carbothionic acid" EXACT RESID-name [] xref: DiffAvg: "-4.03" xref: DiffFormula: "C 0 H -4 N 0 O 0 S 0" xref: DiffMono: "-4.031300" xref: Formula: "C 8 H 8 N 2 O 2 S 1" xref: MassAvg: "196.22" xref: MassMono: "196.030649" xref: Origin: "C, P" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00915 ! modified L-proline residue is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys) [Term] id: MOD:01846 name: methanobactin OB3b copper complex def: "A protein modification that effectively converts two L-cysteine residues, and a copper atom to the methanobactin OB3b copper complex." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0552] comment: Cross-link 2. synonym: "bis[4-(hydroxy[sulfanyl-kappaS]methylidene)-1,3-oxazol-5(4H)-onato-kappaN]copper" EXACT RESID-systematic [] synonym: "METAL copper [Cu-methanobactin OB3b complex]" EXACT UniProt-feature [] synonym: "methanobactin OB3b copper complex" EXACT RESID-name [] xref: DiffAvg: "85.46" xref: DiffFormula: "C 0 Cu 1 H -10 N 0 O 2 S 0" xref: DiffMono: "84.841176" xref: Formula: "C 6 Cu 1 H 0 N 2 O 4 S 2" xref: MassAvg: "291.74" xref: MassMono: "290.859546" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00742 ! copper containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01847 name: L-cysteine sulfinyl phosphate def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine sulfinyl phosphate." [PubMed:16565085, RESID:AA0557] synonym: "(2R)-2-amino-3-[(phosphonooxy)sulfinyl]propanoic acid" EXACT RESID-systematic [] synonym: "cysteine sulfinic phosphoryl ester" EXACT RESID-alternate [] synonym: "L-cysteine sulfinyl phosphate" EXACT RESID-name [] xref: DiffAvg: "111.98" xref: DiffFormula: "C 0 H 1 N 0 O 5 P 1 S 0" xref: DiffMono: "111.956160" xref: Formula: "C 3 H 6 N 1 O 6 P 1 S 1" xref: MassAvg: "215.12" xref: MassMono: "214.965345" xref: Origin: "C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00708 ! sulfur oxygenated L-cysteine is_a: MOD:00861 ! phosphorus containing modified residue [Term] id: MOD:01848 name: S-(spermidinoglutathion-S-yl)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(spermidinoglutathion-S-yl)-L-cysteine." [ChEBI:16613, PubMed:20530482, RESID:AA0558] synonym: "(2R)-2-amino-3-([(2R)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-2-([2-([3-([4-aminobutyl]amino)propyl]carbamoyl)methyl]carbamoyl)ethyl]disulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "cysteine glutathionylspermidine disulfide" EXACT RESID-alternate [] synonym: "L-gamma-glutamyl-[S-(L-cystein-S-yl)]-L-cysteinyl-N-{3-[(4-aminobutyl)amino]propyl}glycinamide" EXACT RESID-alternate [] synonym: "S-(spermidinoglutathion-S-yl)-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "432.54" xref: DiffFormula: "C 17 H 32 N 6 O 5 S 1" xref: DiffMono: "432.215489" xref: Formula: "C 20 H 37 N 7 O 6 S 2" xref: MassAvg: "535.68" xref: MassMono: "535.224674" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01862 ! disulfide conjugated residue [Term] id: MOD:01849 name: S-(2-aminovinyl)-D-cysteine (Cys-Cys) def: "A protein modification that effectively cross-links two L-cysteine residues by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [PubMed:20805503, RESID:AA0204#CYS2] comment: Cross-link 2. synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate [] synonym: "CROSSLNK S-(2-aminovinyl)-D-cysteine (Cys-Cys)" EXACT UniProt-feature [] synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name [] xref: DiffAvg: "-80.10" xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1" xref: DiffMono: "-79.993200" xref: Formula: "C 5 H 7 N 2 O 1 S 1" xref: MassAvg: "143.18" xref: MassMono: "143.027909" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01850 ! S-(2-aminovinyl)-D-cysteine [Term] id: MOD:01850 name: S-(2-aminovinyl)-D-cysteine def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [RESID:AA0204] comment: Cross-link 2. synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate [] synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 5 H 7 N 2 O 1 S 1" xref: MassAvg: "143.18" xref: MassMono: "143.027909" xref: Origin: "C, X" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:01851 ! S-(2-aminovinyl)-cysteine [Term] id: MOD:01851 name: S-(2-aminovinyl)-cysteine def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-cysteine." [PubMed:18688235] comment: Cross-link 2. synonym: "2-amino-3-([2-aminoethenyl]sulfanyl)propanoic acid" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 5 H 7 N 2 O 1 S 1" xref: MassAvg: "143.18" xref: MassMono: "143.027909" xref: Origin: "C, X" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00687 ! thioether crosslinked residues is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01852 name: L-lysinoalanine (Lys-Cys) def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to release hydrogen sulfide and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid." [DeltaMass:0] comment: Cross-link 2. This entry is for a crosslink of peptidyl cysteine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34 with no citation or formula. [JSG] synonym: "Lysinoalanine (from Cysteine)" EXACT DeltaMass-label [] xref: DiffAvg: "-34.08" xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1" xref: DiffMono: "-33.987721" xref: Formula: "C 9 H 15 N 3 O 2" xref: MassAvg: "197.24" xref: MassMono: "197.116427" xref: Origin: "C, K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01853 ! L-lysinoalanine [Term] id: MOD:01853 name: L-lysinoalanine def: "A protein modification that effectively converts an L-lysine residue to L-lysinoalanine either by forming a cross-link with peptidyl-cysteine or peptidyl-serine, or by condensation with free serine." [PubMed:18688235] xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01854 name: sulfur monooxygenated residue def: "A protein modification that effectively adds one oxygen atom to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00680 ! sulfur oxygenated residue [Term] id: MOD:01855 name: sulfur dioxygenated residue def: "A protein modification that effectively adds two oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:00680 ! sulfur oxygenated residue [Term] id: MOD:01856 name: oxazole/oxazoline ring crosslinked residues (Cys) def: "A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid." [PubMed:18688235] is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues [Term] id: MOD:01857 name: 2-(L-cystein-S-yl)-methionine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-methionine residue by a thioether bond to form 2-(L-cystein-S-yl)-methionine." [PubMed:20805502, RESID:AA0559] comment: Cross-link 2. The chirality around the methionine alpha-carbon has not been determined. synonym: "(2R)-2-amino-2-([2-amino-2-carboxyethyl]sulfanyl)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-(L-cystein-S-yl)-methionine" EXACT RESID-name [] synonym: "CROSSLNK 2-(S-cysteinyl)-methionine (Cys-Met)" EXACT UniProt-feature [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 8 H 12 N 2 O 2 S 2" xref: MassAvg: "232.32" xref: MassMono: "232.034020" xref: Origin: "C, M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:01858 name: S-(N-acetylamino)glucosyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(N-acetylamino)glucosyl-L-cysteine." [ChEBI:61631, PubMed:21251913, PubMed:21395300, RESID:AA0560] synonym: "(2R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD S-linked (GlcNAc)" EXACT UniProt-feature [] synonym: "S-(N-acetylamino)glucosyl-L-cysteine" EXACT RESID-name [] synonym: "S-[(N-acetylamino)glycosyl]cysteine" EXACT RESID-alternate [] synonym: "S-[beta-D-(N-acetylamino)glucopyranosyl]cysteine" EXACT RESID-alternate [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5 S 0" xref: DiffMono: "203.079373" xref: Formula: "C 11 H 18 N 2 O 6 S 1" xref: MassAvg: "306.33" xref: MassMono: "306.088557" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00426 ! S-glycosylated residue is_a: MOD:00448 ! N-acetylaminoglucosylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01859 name: 4-amino-3-isothiazolidinone-L-phenylalanine def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form 4-amino-3-isothiazolidinone-L-phenylalanine." [PubMed:17502599, RESID:AA0562] comment: Cross-link 2. synonym: "(2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-phenylpropanoic acid" EXACT RESID-systematic [] synonym: "2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-phenylpropanoic acid" EXACT RESID-alternate [] synonym: "4-amino-3-isothiazolidinone-L-phenylalanine" EXACT RESID-alternate [] synonym: "CROSSLNK N,N-(cysteine-1,S-diyl)phenylalanine (Cys-Phe)" EXACT UniProt-feature [] synonym: "cysteinyl phenylalanine sulfenamide" EXACT RESID-alternate [] synonym: "N,N-(L-cysteine-1,S-diyl)-L-phenylalanine" EXACT RESID-name [] synonym: "phenylalanine-cysteine sulfenyl amide cross-link" EXACT RESID-alternate [] synonym: "phenylalanine-cysteine sulphenyl amide cross-link" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 12 H 12 N 2 O 2 S 1" xref: MassAvg: "248.30" xref: MassMono: "248.061949" xref: Origin: "C, F" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:01861 ! isothiazolidinone ring crosslinked residues [Term] id: MOD:01860 name: L-cysteine bacillithiol disulfide def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine bacillithiol disulfide." [ChEBI:61338, PubMed:19578333, RESID:AA0563] synonym: "(2S)-(2-[S-(L-cystein-S-yl)-L-cysteinyl]amino-2-deoxy-alpha-D-glucopyranosyloxy)-butanedioic acid" EXACT RESID-systematic [] synonym: "BSH" EXACT RESID-alternate [] synonym: "L-cysteine bacillithiol disulfide" EXACT RESID-name [] synonym: "MOD_RES S-bacillithiol cysteine disulfide" EXACT UniProt-feature [] xref: DiffAvg: "396.37" xref: DiffFormula: "C 13 H 20 N 2 O 10 S 1" xref: DiffMono: "396.083866" xref: Formula: "C 16 H 25 N 3 O 11 S 2" xref: MassAvg: "499.51" xref: MassMono: "499.093051" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01862 ! disulfide conjugated residue [Term] id: MOD:01861 name: isothiazolidinone ring crosslinked residues def: "A protein modification that crosslinks two residues by condensation of a cysteine thiol with the amido nitrogen of the following residue to form an isothiazolidinone ring." [PubMed:18688235] comment: The isothiazolidinone ring is usually formed by the reaction of a cysteine sulfenic acid with the amido nitrogen releasing water. is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:01862 name: disulfide conjugated residue def: "A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a substituted sulfanyl group, forming a disulfide bond that does not cross-link two encoded peptide chains." [PubMed:18688235] subset: PSI-MOD-slim synonym: "S-thiolation" EXACT PSI-MOD-alternate [] xref: Origin: "C" xref: TermSpec: "none" is_a: MOD:01886 ! thiolated residue [Term] id: MOD:01863 name: mTRAQ reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems mTRAQ reagent reporter+balance groups." [PubMed:18688235] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01426 ! isotope tagged reagent derivatized residue is_a: MOD:01705 ! isotope tagged reagent acylated residue [Term] id: MOD:01864 name: mTRAQ light reporter+balance reagent acylated residue def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems mTRAQ light reporter+balance group." [UniMod:888] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] synonym: "mTRAQ heavy" RELATED UniMod-description [] xref: DiffAvg: "140.09" xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1" xref: DiffMono: "140.094963" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01863 ! mTRAQ reporter+balance reagent acylated residue is_a: MOD:01868 ! modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da [Term] id: MOD:01865 name: mTRAQ light reporter+balance reagent acylated N-terminal def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:208, UniMod:888#N-term] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] synonym: "mTRAQ light" RELATED UniMod-description [] synonym: "mTRAQ light on nterm" EXACT OMSSA-label [] xref: DiffAvg: "140.09" xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1" xref: DiffMono: "140.094963" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue [Term] id: MOD:01866 name: mTRAQ light reporter+balance reagent N6-acylated lysine def: "A protein modification that effectively replaces the N6-amino hydrogen atom of a lysine residue with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:209, UniMod:888#K] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. subset: PSI-MOD-slim synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] synonym: "mTRAQ light" RELATED UniMod-description [] synonym: "mTRAQ light on K" EXACT OMSSA-label [] xref: DiffAvg: "140.09" xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1" xref: DiffMono: "140.094963" xref: Formula: "(12)C 13 H 24 N 2 (14)N 2 O 1 (16)O 1" xref: MassAvg: "268.19" xref: MassMono: "268.189926" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01867 name: mTRAQ light reporter+balance reagent O4'-acylated tyrosine def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:210, UniMod:888#Y] comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate [] synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED UniMod-alternate [] synonym: "mTRAQ light" RELATED UniMod-description [] synonym: "mTRAQ light on Y" EXACT OMSSA-label [] xref: DiffAvg: "140.09" xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1" xref: DiffMono: "140.094963" xref: Formula: "(12)C 16 H 21 (14)N 3 O 2 (16)O 1" xref: MassAvg: "303.16" xref: MassMono: "303.158292" xref: Origin: "Y" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue [Term] id: MOD:01868 name: modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da def: "Modifications that have monoisotopic mass differences from their respective origins of 140.094963 Da." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da [Term] id: MOD:01869 name: mTRAQ light reporter fragment def: "The protein modification reporter fragment produced by an Applied Biosystems mTRAQ light reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: FormalCharge: "1+" xref: Formula: "(12)C 6 H 13 (14)N 2" xref: MassAvg: "113.11" xref: MassMono: "113.107325" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01870 ! mTRAQ reporter fragment relationship: derives_from MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue [Term] id: MOD:01870 name: mTRAQ reporter fragment def: "A protein modification reporter fragment produced by an Applied Biosystems mTRAQ reagent derivatized residue." [PubMed:18688235] subset: PSI-MOD-slim is_a: MOD:01520 ! modification reporter fragment [Term] id: MOD:01871 name: cyclized N-terminal S-carboxamidomethyl-L-cysteine def: "A protein modification that effectively cyclizes an S-carboxamidomethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of ammonia." [DeltaMass:336, PubMed:12643538, UniMod:26] subset: PSI-MOD-slim synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label [] synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate [] synonym: "Otc" EXACT DeltaMass-label [] synonym: "Pyro-carbamidomethyl" RELATED UniMod-interim [] synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED UniMod-description [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0" xref: DiffMono: "-17.026549" xref: Formula: "C 5 H 6 N 1 O 2 S 1" xref: MassAvg: "144.17" xref: MassMono: "144.011924" xref: Origin: "MOD:01060" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00397 ! iodoacetamide derivatized residue is_a: MOD:00419 ! (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine [Term] id: MOD:01872 name: cyclized N-terminal S-carboxymethyl-L-cysteine def: "A protein modification that effectively cyclizes an S-carboxymethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of water." [PubMed:12643538, UniMod:26] comment: Contrary to the impression given in UniMod entry 26, the cyclization of N-terminal S-carboxymethyl-L-cysteine is not reported in PubMed:1263538. The cyclization would be expected to proceed under strongly acidic conditions [JSG]. subset: PSI-MOD-slim synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label [] synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate [] synonym: "Otc" EXACT DeltaMass-label [] synonym: "Pyro-carbamidomethyl" RELATED UniMod-interim [] synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED UniMod-description [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 5 H 6 N 1 O 2 S 1" xref: MassAvg: "144.17" xref: MassMono: "144.011924" xref: Origin: "MOD:01061" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00399 ! iodoacetic acid derivatized residue is_a: MOD:00419 ! (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine [Term] id: MOD:01873 name: N-carboxy-L-alanine def: "A protein modification that effectively converts an L-alanine residue to N-carboxy-L-alanine." [PubMed:18688235, PubMed:4593770, PubMed:4647257, PubMed:8312270] comment: This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. synonym: "(S)-2-carboxyamino-propanoic acid" EXACT PSI-MOD-alternate [] synonym: "2-carbamic-propanoic acid" EXACT PSI-MOD-alternate [] synonym: "N-carboxymethionine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "44.01" xref: DiffFormula: "C 1 H 0 N 0 O 2" xref: DiffMono: "43.989829" xref: Formula: "C 4 H 6 N 1 O 3" xref: MassAvg: "116.10" xref: MassMono: "116.034768" xref: Origin: "A" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:01152 ! carboxylated residue [Term] id: MOD:01874 name: N-carboxy-L-valine def: "A protein modification that effectively converts an L-alanine residue to N-carboxy-L-valine." [PubMed:18688235, PubMed:4593770, PubMed:4647257, PubMed:8312270] comment: This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. synonym: "(S)-2-carboxyamino-propanoic acid" EXACT PSI-MOD-alternate [] synonym: "2-carbamic-propanoic acid" EXACT PSI-MOD-alternate [] synonym: "N-carboxymethionine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "44.01" xref: DiffFormula: "C 1 H 0 N 0 O 2" xref: DiffMono: "43.989829" xref: Formula: "C 6 H 10 N 1 O 3" xref: MassAvg: "144.15" xref: MassMono: "144.066068" xref: Origin: "V" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00920 ! modified L-valine residue is_a: MOD:01152 ! carboxylated residue [Term] id: MOD:01875 name: N6-acylated L-lysine def: "A protein modification that effectively replaces an N6-amino hydrogen atom of L-lysine with an acyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "N6AcylLys" EXACT PSI-MOD-label [] xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00670 ! N-acylated residue is_a: MOD:00912 ! modified L-lysine residue [Term] id: MOD:01876 name: 4x(1)H,4x(12)C-labeled alpha-amino succinylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(12)C labeled succinyl group." [PubMed:11857757, PubMed:12175151, PubMed:12716131, UniMod:64] synonym: "Succinic anhydride labeling reagent, light form (+4amu, 4H2) site N-term" RELATED UniMod-description [] synonym: "Succinyl" RELATED PSI-MS-label [] xref: DiffAvg: "100.02" xref: DiffFormula: "(12)C 4 (1)H 4 O 3" xref: DiffMono: "100.016044" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00457 ! alpha-amino succinylated residue is_a: MOD:01426 ! isotope tagged reagent derivatized residue [Term] id: MOD:01877 name: 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid def: "A protein modification that effectively converts an L-cysteine residue and an L-arginine residue to 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid." [PubMed:20961038, RESID:AA0553] comment: Cross-link 2. synonym: "(4Z)-2-(4-guanidinobutanoyl)-5-oxo-4-(sulfanylmethylidene)-4,5-dihydro-1H-imidazole" EXACT RESID-alternate [] synonym: "2-(4-guanidinobutanoyl)-5-hydroxy-1H-imidazole-4-carbothioic O-acid" EXACT RESID-systematic [] synonym: "2-(4-guanidinobutanoyl)-5-hydroxy-4-thioformyl-1H-imidazole [tautomer]" EXACT RESID-alternate [] synonym: "2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid" EXACT RESID-name [] synonym: "CROSSLNK 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid (Arg-Cys)" EXACT UniProt-feature [] xref: DiffAvg: "-6.05" xref: DiffFormula: "C 0 H -6 N 0 O 0 S 0" xref: DiffMono: "-6.046950" xref: Formula: "C 9 H 12 N 5 O 2 S 1" xref: MassAvg: "254.29" xref: MassMono: "254.071171" xref: Origin: "C, R" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01883 ! 5-imidazolinone ring crosslinked residues (Cys) [Term] id: MOD:01878 name: L-threonine 5-hydroxyoxazole-4-carbonthionic acid def: "A protein modification that effectively converts an L-cysteine residue and an L-threonine residue to L-threonine 5-hydroxyoxazole-4-carbothionic acid." [PubMed:20961038, RESID:AA0554] comment: Cross-link 2. synonym: "(4Z)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-(sulfanylmethylidene)-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate [] synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-hydroxy-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic [] synonym: "CROSSLNK Threonine 5-hydroxy-oxazole-4-carbonthionic acid (Thr-Cys)" EXACT UniProt-feature [] synonym: "L-threonine 5-hydroxy-oxazole-4-carbonthionic acid" EXACT RESID-name [] xref: DiffAvg: "-4.03" xref: DiffFormula: "C 0 H -4 N 0 O 0 S 0" xref: DiffMono: "-4.031300" xref: Formula: "C 7 H 8 N 2 O 3 S 1" xref: MassAvg: "200.21" xref: MassMono: "200.025563" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys) [Term] id: MOD:01879 name: methanobactin SB2 copper complex def: "A protein modification that effectively converts two L-cysteine residues, an L-arginine residue, an L-threonine residue and a copper atom to the methanobactin SB2 copper complex." [PubMed:20961038, RESID:AA0555] comment: Cross-link 2. synonym: "[5-(hydroxy[sulfanyl-kappaS]methylene)-3,5-dihydro-4H-imidazol-4-onato-kappaN1][4-(hydroxy[sulfanyl-kappaS]methylene)-1,3-oxazol-5(4H)-onato-kappaN]copper" EXACT RESID-systematic [] synonym: "METAL copper [Cu-methanobactin SB2 complex]" EXACT UniProt-feature [] synonym: "methanobactin SB2 copper complex" EXACT RESID-name [] xref: DiffAvg: "84.48" xref: DiffFormula: "C 0 Cu 1 H -9 N 1 O 1 S 0" xref: DiffMono: "83.857161" xref: Formula: "C 6 Cu 1 H 1 N 3 O 3 S 2" xref: MassAvg: "290.76" xref: MassMono: "289.875530" xref: Origin: "C, C, R, T" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00742 ! copper containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01880 name: L-deoxyhypusine def: "modification from RESID" [ChEBI:50038, PubMed:16452303, RESID:AA0564] synonym: "(2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid" EXACT RESID-systematic [] synonym: "deoxyhypusine" EXACT RESID-alternate [] synonym: "L-deoxyhypusine" EXACT RESID-name [] synonym: "N6-(4-aminobutyl)lysine" EXACT RESID-alternate [] xref: DiffAvg: "71.12" xref: DiffFormula: "C 4 H 9 N 1 O 0" xref: DiffMono: "71.073499" xref: Formula: "C 10 H 21 N 3 O 1" xref: MassAvg: "199.30" xref: MassMono: "199.168462" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01884 ! 4-aminobutylated residue [Term] id: MOD:01881 name: 3-(L-phenylalan-2'-yl)-L-valine def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-valine residue by a free radical process effectively releasing a hydrogen molecule and forming 3-(L-phenylalan-2'-yl)-L-valine." [PubMed:21596985, RESID:AA0565] comment: Cross-link 2. synonym: "(2S)-2-amino-4-(2-[(2S)-2-amino-2-carboxyethyl]phenyl)-3-methylbutanoic acid" EXACT RESID-systematic [] synonym: "3-(L-phenylalan-2'-yl)-L-valine" EXACT RESID-name [] synonym: "symerythrin valine-phenylalanine cross-link" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "C 14 H 16 N 2 O 2" xref: MassAvg: "244.29" xref: MassMono: "244.121178" xref: Origin: "F, V" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00692 ! uncategorized crosslinked residues is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:00920 ! modified L-valine residue [Term] id: MOD:01882 name: 5-imidazolinone ring crosslinked residues (Gly) def: "A protein modification that effectively crosslinks the carbonyl of an amino acid residue at position n with the alpha amino of a glycine residue at position n+2 to form a 5-imidazolinone ring." [PubMed:18688235] is_a: MOD:00691 ! 5-imidazolinone ring crosslinked residues [Term] id: MOD:01883 name: 5-imidazolinone ring crosslinked residues (Cys) def: "A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 5-imidazolinone ring." [PubMed:18688235] is_a: MOD:00691 ! 5-imidazolinone ring crosslinked residues [Term] id: MOD:01884 name: 4-aminobutylated residue def: "A protein modification that effectively replaces a hydrogen atom with a 4-aminobutyl group, usually derived from spermidine." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00001 ! alkylated residue [Term] id: MOD:01885 name: biotinylated residue def: "A protein modification that effectively replaces a hydrogen atom with a biotinyl group." [PubMed:18688235] subset: PSI-MOD-slim synonym: "5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl" EXACT PSI-MOD-alternate [] synonym: "Biotinylation" EXACT PSI-MOD-alternate [] synonym: "BtnRes" EXACT PSI-MOD-label [] xref: DiffAvg: "226.29" xref: DiffFormula: "C 10 H 14 N 2 O 2 S 1" xref: DiffMono: "226.077599" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue [Term] id: MOD:01886 name: thiolated residue def: "A protein modification that effectively replaces a hydrogen atom with an sulfanyl or substituted sulfanyl group." [PubMed:18688235] subset: PSI-MOD-slim xref: Origin: "X" xref: TermSpec: "none" is_a: MOD:00860 ! sulfur containing modified residue [Term] id: MOD:01887 name: Uniblue A derivatized lysine def: "A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A lysine adduct." [PubMed:18688235] subset: PSI-MOD-slim synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate [] synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate [] synonym: "N6UniblueALys" EXACT PSI-MOD-label [] synonym: "Uniblue A" EXACT PSI-MOD-alternate [] xref: DiffAvg: "484.50" xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2" xref: DiffMono: "484.039893" xref: Formula: "C 28 H 28 N 4 O 8 S 2" xref: MassAvg: "612.67" xref: MassMono: "612.134856" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01659 ! Uniblue A derivatized residue [Term] id: MOD:01888 name: didehydrogenated residue def: "A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) from a residue." [UniMod:401] subset: PSI-MOD-slim synonym: "2dHRes" EXACT PSI-MOD-label [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0" xref: DiffMono: "-2.015650" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00683 ! dehydrogenated residue [Term] id: MOD:01889 name: S-(2-succinyl)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(2-succinyl)-L-cysteine, by addition of either fumaric acid or maleic acid." [PubMed:16624247, PubMed:18448829, PubMed:20677745, RESID:AA0561, UniMod:957] synonym: "(2R)-2-amino-3-([(1R)-1,2-dicarboxyethyl]sulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "(2R)-2-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanedioic acid" EXACT RESID-alternate [] synonym: "2-((2-amino-2-carboxyethyl)thio)butanedioic acid" EXACT RESID-alternate [] synonym: "2-amino-3-(1,2-dicarboxyethylthio)propanoic acid" EXACT RESID-alternate [] synonym: "S-(1,2-dicarboxyethyl)cysteine" EXACT RESID-alternate [] synonym: "S-(2-succinyl)-L-cysteine" EXACT RESID-name [] synonym: "S-(2-succinyl)cysteine" EXACT RESID-alternate [] synonym: "S-[(2R)-2-succinyl]-L-cysteine" EXACT RESID-alternate [] xref: DiffAvg: "116.07" xref: DiffFormula: "C 4 H 4 N 0 O 4 S 0" xref: DiffMono: "116.010959" xref: Formula: "C 7 H 9 N 1 O 5 S 1" xref: MassAvg: "219.21" xref: MassMono: "219.020143" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00001 ! alkylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01890 name: N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) def: "A protein modification that effectively crosslinks an N-formyl-L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine." [PubMed:19622680, RESID:AA0566#FMET] comment: Cross-link 2. synonym: "(2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "N-[(L-histidin-1'-yl)methyl]-L-methionine" EXACT RESID-name [] xref: DiffAvg: "-16.00" xref: DiffFormula: "C 0 H 0 N 0 O -1 S 0" xref: DiffMono: "-15.994915" xref: Formula: "C 12 H 17 N 4 O 2 S 1" xref: MassAvg: "281.35" xref: MassMono: "281.107222" xref: Origin: "H, MOD:00030" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01450 ! modified N-formyl-L-methionine residue [Term] id: MOD:01891 name: N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) def: "A protein modification that effectively crosslinks an L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine." [PubMed:19622680, RESID:AA0566#MET] comment: Cross-link 2. synonym: "(2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "N-[(L-histidin-1'-yl)methyl]-L-methionine" EXACT RESID-name [] xref: DiffAvg: "12.01" xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0" xref: DiffMono: "12.000000" xref: Formula: "C 12 H 17 N 4 O 2 S 1" xref: MassAvg: "281.35" xref: MassMono: "281.107222" xref: Origin: "H, M" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:01892 name: N6-crotonyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-crotonyl-L-lysine." [PubMed:21925322, RESID:AA0567] synonym: "(2S)-2-amino-6-[(2E)-but-2-enamido]hexanoic acid" EXACT RESID-alternate [] synonym: "(2S)-2-amino-6-[(2E)-but-2-enoylamino]hexanoic acid" EXACT RESID-systematic [] synonym: "(2S)-2-azanyl-6-[(2E)-but-2-enoylazanyl]hexanoic acid" EXACT RESID-alternate [] synonym: "MOD_RES N6-crotonyl-L-lysine" EXACT UniProt-feature [] synonym: "N(epsilon)-crotonyllysine" EXACT RESID-alternate [] synonym: "N6-(E)-crotonyllysine" EXACT RESID-alternate [] synonym: "N6-[(2E)-2-butenoyl]-L-lysine" EXACT RESID-alternate [] synonym: "N6-crotonyl-L-lysine" EXACT RESID-name [] synonym: "N6-crotonyllysine" EXACT RESID-alternate [] synonym: "N6-trans-crotonyllysine" EXACT RESID-alternate [] xref: DiffAvg: "68.07" xref: DiffFormula: "C 4 H 4 N 0 O 1" xref: DiffMono: "68.026215" xref: Formula: "C 10 H 16 N 2 O 2" xref: MassAvg: "196.25" xref: MassMono: "196.121178" xref: Origin: "K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01893 name: N6-malonyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-malonyl-L-lysine." [PubMed:21908771, PubMed:8349414, RESID:AA0568] synonym: "(2S)-2-amino-6-[(carboxyacetyl)amino]hexanoic acid" EXACT RESID-systematic [] synonym: "2-azanyl-6-[(carboxyacetyl)azanyl]hexanoic acid" EXACT RESID-alternate [] synonym: "malonyllysine" EXACT RESID-alternate [] synonym: "MOD_RES N6-malonyllysine" EXACT UniProt-feature [] synonym: "N(epsilon)-(malonyl)lysine" EXACT RESID-alternate [] synonym: "N6-(carboxyacetyl)lysine" EXACT RESID-alternate [] synonym: "N6-malonyl-L-lysine" EXACT RESID-name [] synonym: "N6-malonyllysine" EXACT RESID-alternate [] xref: DiffAvg: "86.05" xref: DiffFormula: "C 3 H 2 N 0 O 3" xref: DiffMono: "86.000394" xref: Formula: "C 9 H 14 N 2 O 4" xref: MassAvg: "214.22" xref: MassMono: "214.095357" xref: Origin: "K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01894 name: propanoylated residue def: "A protein modification that effectively replaces a hydrogen atom with an propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:58] synonym: "Propionate labeling reagent light form (N-term & K)" RELATED UniMod-description [] synonym: "Propionyl" RELATED PSI-MS-label [] xref: DiffAvg: "56.06" xref: DiffFormula: "C 3 H 4 O 1" xref: DiffMono: "56.026215" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue [Term] id: MOD:01895 name: alpha-amino 3x(12)C-labeled propanoylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(12)C-labeled propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, UniMod:58#N-term] synonym: "Propionate labeling reagent light form (N-term & K)" RELATED UniMod-description [] synonym: "Propionyl" RELATED PSI-MS-label [] xref: DiffAvg: "56.03" xref: DiffFormula: "(12)C 3 H 4 O 1" xref: DiffMono: "56.026215" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00451 ! alpha-amino propanoylated residue [Term] id: MOD:01896 name: trifluoroacetic acid adduct def: "A protein modification produced by trifluoroacetic acid forming an adduct, either a salt or a hydrogen bonded carboxylic acid dimer, with an amino acid residue." [PubMed:18688235] comment: Trifluoroacetic acid has been observed to form adducts in both negative and positive mode analysis (Mark Collins, private communication) [JSG]. synonym: "TFA" EXACT DeltaMass-label [] xref: DiffAvg: "114.02" xref: DiffFormula: "C 2 F 3 H 1 O 2" xref: DiffMono: "113.992864" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00498 ! fluorinated residue is_a: MOD:00848 ! reagent derivatized residue [Term] id: MOD:01897 name: 5-hydroxy-3-methyl-L-proline (Ile) def: "A protein modification that effectively converts an L-isoleucine residue to 5-hydroxy-3-methyl-L-proline." [PubMed:21788474, PubMed:7592021, PubMed:8557573, RESID:AA0473] synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name [] synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate [] synonym: "5Hy3MePro(Ile)" EXACT PSI-MOD-label [] synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate [] synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature [] xref: DiffAvg: "13.98" xref: DiffFormula: "C 0 H -2 N 0 O 1" xref: DiffMono: "13.979265" xref: Formula: "C 6 H 9 N 1 O 2" xref: MassAvg: "127.14" xref: MassMono: "127.063329" xref: Origin: "I" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00601 ! cyclized residue is_a: MOD:00679 ! carbon oxygenated residue is_a: MOD:00910 ! modified L-isoleucine residue is_a: MOD:01888 ! didehydrogenated residue is_a: MOD:01905 ! 5-hydroxy-3-methyl-L-proline [Term] id: MOD:01898 name: N2,N2-dimethyl-L-arginine def: "modification from RESID" [PubMed:21568297, PubMed:21950656, RESID:AA0569] synonym: "(2S)-5-[(diaminomethylidene)amino]-2-(dimethylamino)pentanoic acid" EXACT RESID-systematic [] synonym: "(2S)-5-carbamimidamido-2-(dimethylamino)pentanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "MOD_RES N2,N2-dimethylarginine" EXACT UniProt-feature [] synonym: "N(alpha),N(alpha)-dimethylarginine" EXACT RESID-alternate [] synonym: "N2,N2-dimethyl-L-arginine" EXACT RESID-name [] synonym: "N2,N2-dimethylarginine" EXACT RESID-alternate [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 8 H 17 N 4 O 1" xref: MassAvg: "185.25" xref: MassMono: "185.140236" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00783 ! dimethylated L-arginine [Term] id: MOD:01899 name: L-arginine thiazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-arginine residue and an L-cysteine residue to form arginine thiazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0570] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-4-([diaminomethylidene]amino)butyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "CROSSLNK Thiazole-4-carboxylic acid (Arg-Cys)" EXACT UniProt-feature [] synonym: "L-arginine thiazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 9 H 13 N 5 O 1 S 1" xref: MassAvg: "239.30" xref: MassMono: "239.084081" xref: Origin: "C, R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00902 ! modified L-arginine residue is_a: MOD:01420 ! thiazole/thiazoline ring croslinked residues is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01900 name: L-cysteine 5-methyloxazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-cysteine 5-methyloxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0571] comment: Cross-link 2. synonym: "2-[(1R)-1-amino-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[(1R)-1-azanyl-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Cys-Thr)" EXACT UniProt-feature [] synonym: "L-cysteine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0" xref: DiffMono: "-20.026215" xref: Formula: "C 7 H 8 N 2 O 2 S 1" xref: MassAvg: "184.21" xref: MassMono: "184.030649" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr) is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01901 name: L-threonine 5-methyloxazole-4-carboxylic acid def: "A protein modification that effectively crosslinks two L-threonine residues to form L-threonine 5-methyloxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0572] comment: Cross-link 2. synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[(1S,2R)-1-azanyl-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Thr-Thr)" EXACT UniProt-feature [] synonym: "L-threonine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1" xref: DiffMono: "-20.026215" xref: Formula: "C 8 H 10 N 2 O 3" xref: MassAvg: "182.18" xref: MassMono: "182.069142" xref: Origin: "T, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr) is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01902 name: L-isoleucine oxazole-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-isoleucine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0573] comment: Cross-link 2. synonym: "2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[(1S,2S)-1-azanyl-2-methylbutyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Oxazole-4-carboxylic acid (Ile-Ser)" EXACT UniProt-feature [] synonym: "L-isoleucine oxazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1" xref: DiffMono: "-20.026215" xref: Formula: "C 9 H 12 N 2 O 2" xref: MassAvg: "180.21" xref: MassMono: "180.089878" xref: Origin: "I, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00910 ! modified L-isoleucine residue is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01903 name: L-serine oxazole-4-carboxylic acid def: "A protein modification that effectively crosslinks two L-serine residues to form serine oxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0574] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[(1S)-1-azanyl-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK Oxazole-4-carboxylic acid (Ser-Ser)" EXACT UniProt-feature [] synonym: "L-serine oxazole-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-20.03" xref: DiffFormula: "C 0 H -4 N 0 O -1" xref: DiffMono: "-20.026215" xref: Formula: "C 6 H 6 N 2 O 3" xref: MassAvg: "154.13" xref: MassMono: "154.037842" xref: Origin: "S, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser) is_a: MOD:01888 ! didehydrogenated residue [Term] id: MOD:01904 name: L-serine 5-methyloxazoline-4-carboxylic acid def: "A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazoline-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0575] comment: Cross-link 2. synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazoline-4-carboxylic acid" EXACT RESID-alternate [] synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic [] synonym: "2-[(1S)-1-azanyl-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate [] synonym: "CROSSLNK 5-methyloxazoline-4-carboxylic acid (Ser-Thr)" EXACT UniProt-feature [] synonym: "L-serine 5-methyloxazoline-4-carboxylic acid" EXACT RESID-name [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 7 H 10 N 2 O 3" xref: MassAvg: "170.17" xref: MassMono: "170.069142" xref: Origin: "S, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr) [Term] id: MOD:01905 name: 5-hydroxy-3-methyl-L-proline def: "A protein modification that effectively converts a source amino acid residue to 5-hydroxy-3-methyl-L-proline." [PubMed:7592021, PubMed:8557573, RESID:AA0473] synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name [] synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate [] synonym: "5Hy3MePro" EXACT PSI-MOD-label [] synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate [] synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 9 N 1 O 2" xref: MassAvg: "127.14" xref: MassMono: "127.063329" xref: Origin: "X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues relationship: has_functional_parent MOD:01024 ! monohydroxylated proline [Term] id: MOD:01906 name: dehydromethionine def: "A protein modification that effectively converts an L-methionine residue to dehydromethionine." [PubMed:18688235, PubMed:19775156] synonym: "(3S)-3-carboxy-1-methylisothiazolidin-1-ium" EXACT PSI-MOD-alternate [] synonym: "L-dehydromethionine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-1.01" xref: DiffFormula: "C 0 H -1 N 0 O 0 S 0" xref: DiffMono: "-1.008374" xref: FormalCharge: "1+" xref: Formula: "C 5 H 9 N 1 O 1 S 1" xref: MassAvg: "131.19" xref: MassMono: "131.039936" xref: Origin: "M" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00601 ! cyclized residue is_a: MOD:00913 ! modified L-methionine residue [Term] id: MOD:01907 name: dehydromethionine (from L-methioninium) def: "A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to dehydromethionine." [PubMed:18688235, PubMed:19775156] comment: This process accounts only for cyclizaation and not protonation. The alternative process (MOD:01906) accounts for both protonation and cyclization. synonym: "(3S)-3-carboxy-1-methylisothiazolidin-1-ium" EXACT PSI-MOD-alternate [] synonym: "L-dehydromethionine" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.016199" xref: FormalCharge: "1+" xref: Formula: "C 5 H 9 N 1 O 1 S 1" xref: MassAvg: "131.19" xref: MassMono: "131.039936" xref: Origin: "MOD:001464" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:00601 ! cyclized residue is_a: MOD:00913 ! modified L-methionine residue relationship: derives_from MOD:01464 ! protonated L-methionine (L-methioninium) residue [Term] id: MOD:01908 name: 4-sulfophenyl isothiocyanate alpha-amino derivatized residue def: "A protein modification that effectively converts a residue to the 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue." [PubMed:14689565, PubMed:14745769, PubMed:15549660, PubMed:16526082, UniMod:261#N-term] synonym: "4-sulfophenyl isothiocyanate" RELATED UniMod-description [] synonym: "alpha-amino-[(4-sulfophenyl)carbamothioyl] residue" EXACT PSI-MOD-alternate [] synonym: "SPITC" RELATED PSI-MS-label [] xref: DiffAvg: "215.24" xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2" xref: DiffMono: "214.971085" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue [Term] id: MOD:01909 name: 6x(13)C labeled 4-sulfophenyl isothiocyanate alpha-amino derivatized residue def: "A protein modification that effectively converts a residue to the 6x(13)C labeled 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue." [PubMed:11467524, PubMed:16526082, UniMod:464#N-term] synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED UniMod-description [] synonym: "SPITC:13C(6)" RELATED PSI-MS-label [] xref: DiffAvg: "220.99" xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2" xref: DiffMono: "220.991214" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00880 ! 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue [Term] id: MOD:01910 name: monofluorinated residue def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one fluorine atom." [UniMod:127] synonym: "F1Res" EXACT PSI-MOD-label [] xref: DiffAvg: "17.99" xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0" xref: DiffMono: "17.990578" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00498 ! fluorinated residue [Term] id: MOD:01911 name: monochlorinated residue def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one chlorine atom." [UniMod:936] synonym: "Cl1Res" EXACT PSI-MOD-label [] xref: DiffAvg: "34.44" xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" xref: DiffMono: "33.961028" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00753 ! chlorinated residue [Term] id: MOD:01912 name: monobrominated residue def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one bromine atom." [UniMod:340] synonym: "Br1Res" EXACT PSI-MOD-label [] xref: DiffAvg: "78.90" xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0" xref: DiffMono: "77.910512" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00754 ! brominated residue [Term] id: MOD:01913 name: monochlorinated L-tryptophan def: "A protein modification that effectively substitutes one hydrogen atom of an L-tryptophan residue with one chlorine atom." [PubMed:18688235] synonym: "Cl1Trp" EXACT PSI-MOD-label [] xref: DiffAvg: "34.44" xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0" xref: DiffMono: "33.961028" xref: Formula: "C 11 Cl 1 H 9 N 2 O 1" xref: MassAvg: "220.66" xref: MassMono: "220.040341" xref: Origin: "W" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:01068 ! halogenated tryptophan is_a: MOD:01911 ! monochlorinated residue [Term] id: MOD:01914 name: O5-galactosyl-L-hydroxylysine def: "A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine." [PMID:743239, PubMed:17516569, UniMod:907] comment: Secondary to RESID:AA0028. This intermediate is rarely observed [JSG]. subset: PSI-MOD-slim synonym: "Galactosyl hydroxylysine" RELATED UniMod-description [] synonym: "OGal5HyLys" EXACT PSI-MOD-label [] xref: DiffAvg: "178.14" xref: DiffFormula: "C 6 H 10 N 0 O 6" xref: DiffMono: "178.047738" xref: Formula: "C 16 H 22 N 2 O 7" xref: MassAvg: "354.36" xref: MassMono: "354.142701" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00037 ! 5-hydroxy-L-lysine is_a: MOD:00396 ! O-glycosylated residue is_a: MOD:00476 ! galactosylated residue [Term] id: MOD:01915 name: N-formyl-L-alanine def: "A protein modification that effectively converts an L-alanine residue to N-formyl-L-alanine." [PubMed:9334739, RESID:AA0576] synonym: "(2S)-2-(formylamino)propanoic acid" EXACT RESID-systematic [] synonym: "2-formamidopropanoic acid" EXACT RESID-alternate [] synonym: "2-formamidopropionic acid" EXACT RESID-alternate [] synonym: "N-formyl-L-alanine" EXACT RESID-name [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 4 H 6 N 1 O 2" xref: MassAvg: "100.10" xref: MassMono: "100.039853" xref: Origin: "A" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00409 ! N-formylated residue is_a: MOD:00901 ! modified L-alanine residue [Term] id: MOD:01916 name: O4'-(N-acetylamino)galactosyl-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to O4'-(N-acetylamino)galactosyl-L-tyrosine." [PubMed:21712440, PubMed:21983924, RESID:AA0577] synonym: "(2S)-2-amino-3-(D-2-acetamido-2-deoxygalactopyranosyloxy)phenylpropanoic acid" EXACT RESID-systematic [] synonym: "CARBOHYD O-linked (GalNAc)" EXACT UniProt-feature [] synonym: "mucin type O-glycosyltyrosine" EXACT RESID-alternate [] synonym: "O4'-(N-acetylamino)galactosyl-L-tyrosine" EXACT RESID-name [] synonym: "O4'-(N-acetylgalactosaminyl)tyrosine" EXACT RESID-alternate [] synonym: "O4'-glycosyl-L-tyrosine" EXACT RESID-alternate [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 17 H 22 N 2 O 7" xref: MassAvg: "366.37" xref: MassMono: "366.142701" xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00563 ! N-acetylaminogalactosylated residue is_a: MOD:01927 ! O-glycosyl-L-tyrosine [Term] id: MOD:01917 name: N6-(L-isoaspartyl)-L-lysine (Asp) def: "A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of water." [ChEBI:21862, PubMed:11000116, PubMed:15044436, PubMed:18063798, PubMed:6503713, RESID:AA0294#ASP] comment: Cross-link 2. synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate [] synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature [] synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate [] synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate [] synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name [] synonym: "XLNK-4Asp-N6Lys(Asp)" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 10 H 15 N 3 O 3" xref: MassAvg: "225.25" xref: MassMono: "225.111341" xref: Origin: "D, K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01929 ! N6-(L-isoaspartyl)-L-lysine [Term] id: MOD:01918 name: (2S,5S)-5-hydroxylysine def: "A protein modification that effectively converts an L-lysine residue to (2S,5S)-5-hydroxylysine." [PubMed:19574390, PubMed:22238144, RESID:AA0578] subset: PSI-MOD-slim synonym: "(2S,5S)-2,6-diamino-5-hydroxyhexanoic acid" EXACT RESID-systematic [] synonym: "(2S,5S)-5-hydroxylysine" EXACT RESID-name [] synonym: "2,6-bisazanyl-5-hydroxyhexanoic acid" EXACT RESID-alternate [] synonym: "2,6-diamino-2,3,4,6-tetradeoxyhexonic acid" EXACT RESID-alternate [] synonym: "alpha,epsilon-diamino-delta-hydroxycaproic acid" EXACT RESID-alternate [] synonym: "L-allo-delta-hydroxylysine" EXACT RESID-alternate [] synonym: "L-threo-delta-hydroxylysine" EXACT RESID-alternate [] synonym: "MOD_RES (5S)-5-hydroxylysine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 12 N 2 O 2" xref: MassAvg: "144.17" xref: MassMono: "144.089878" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00037 ! 5-hydroxy-L-lysine [Term] id: MOD:01919 name: (2S,3S)-3-hydroxyaspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to (2S,3S)-3-hydroxyaspartic acid." [ChEBI:10696, PubMed:21177872, RESID:AA0579] subset: PSI-MOD-slim synonym: "(2S,3S)-2-amino-3-hydroxybutanedioic acid" EXACT RESID-systematic [] synonym: "(2S,3S)-3-hydroxyaspartic acid" EXACT RESID-name [] synonym: "(3S)-3-hydroxy-L-aspartic acid" EXACT RESID-alternate [] synonym: "2-amino-3-hydroxysuccinic acid" EXACT RESID-alternate [] synonym: "2-azanyl-3-hydroxybutanedioic acid" EXACT RESID-alternate [] synonym: "3-hydroxyaspartic acid" EXACT RESID-alternate [] synonym: "L-threo-3-hydroxyaspartic acid" EXACT RESID-alternate [] synonym: "L-threo-beta-hydroxyaspartic acid" EXACT RESID-alternate [] synonym: "MOD_RES (3S)-3-hydroxyaspartate" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 4 H 5 N 1 O 4" xref: MassAvg: "131.09" xref: MassMono: "131.021858" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01926 ! 3-hydroxy-L-aspartic acid [Term] id: MOD:01920 name: 3-hydroxy-L-histidine def: "A protein modification that effectively converts an L-histidine residue to 3-hydroxy-L-histidine." [PubMed:21251231, RESID:AA0580] synonym: "(2S)-2-amino-3-hydroxy-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic [] synonym: "3-hydroxy-L-histidine" EXACT RESID-name [] synonym: "MOD_RES 3-hydroxyhistidine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 7 N 3 O 2" xref: MassAvg: "153.14" xref: MassMono: "153.053826" xref: Origin: "H" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00677 ! hydroxylated residue [Term] id: MOD:01921 name: D-aspartic acid (Asp) def: "A protein modification that effectively converts an L-aspartic acid residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190#ASP] synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic [] synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] synonym: "aminosuccinic acid" EXACT RESID-alternate [] synonym: "D-aspartic acid" EXACT RESID-name [] xref: DiffAvg: "0.00" xref: DiffFormula: "C 0 H 0 N 0 O 0" xref: DiffMono: "0.000000" xref: Formula: "C 4 H 5 N 1 O 3" xref: MassAvg: "115.09" xref: MassMono: "115.026943" xref: Origin: "D" xref: Source: "artifactual" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01942 ! D-aspartic acid [Term] id: MOD:01922 name: 3-methoxydehydroalanine def: "A protein modification that effectively converts an L-serine residue to 3-methoxydehydroalanine." [PubMed:19745839, RESID:AA0582] synonym: "2-amino-3-methoxyprop-2-enoic acid" EXACT RESID-systematic [] synonym: "3-methoxydehydroalanine" EXACT RESID-name [] synonym: "3-methoxydidehydroalanine" EXACT RESID-alternate [] xref: DiffAvg: "12.01" xref: DiffFormula: "C 1 H 0 N 0 O 0" xref: DiffMono: "12.000000" xref: Formula: "C 4 H 5 N 1 O 2" xref: MassAvg: "99.09" xref: MassMono: "99.032028" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue relationship: has_functional_parent MOD:00189 ! dehydroalanine (Ser) [Term] id: MOD:01923 name: N6-(L-aspartyl)-L-lysine def: "A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-aspartyl)-L-lysine and the release of water." [PubMed:15044436, RESID:AA0583] comment: Cross-link 2. synonym: "(2S)-2-amino-6-([(2S)-2-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "alpha-(N6-lysyl)aspartyl acid" EXACT RESID-alternate [] synonym: "aspartyl N6-lysine" EXACT RESID-alternate [] synonym: "N(epsilon)-(alpha-aspartyl)lysine" EXACT RESID-alternate [] synonym: "N6-(L-aspartyl)-L-lysine" EXACT RESID-name [] synonym: "XLNK-4Asp-N6Lys(Asp)" EXACT PSI-MOD-label [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 10 H 16 N 3 O 4" xref: MassAvg: "242.26" xref: MassMono: "242.114081" xref: Origin: "D, K" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00688 ! isopeptide crosslinked residues is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01924 name: S-octanoyl-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-octanoyl-L-cysteine." [PubMed:12591875, PubMed:16342964, RESID:AA0584] synonym: "(2S)-2-amino-3-(octanoylsulfanyl)propanoic acid" EXACT RESID-systematic [] synonym: "2-amino-3-(octanoylthio)propanoic acid" EXACT RESID-alternate [] synonym: "ACT_SITE Acyl-thioester intermediate" EXACT UniProt-feature [] synonym: "cysteine octanoate thioester" EXACT RESID-alternate [] synonym: "S-octanoyl-L-cysteine" EXACT RESID-name [] xref: DiffAvg: "126.20" xref: DiffFormula: "C 8 H 14 N 0 O 1 S 0" xref: DiffMono: "126.104465" xref: Formula: "C 11 H 19 N 1 O 2 S 1" xref: MassAvg: "229.34" xref: MassMono: "229.113650" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00666 ! octanoylated residue is_a: MOD:00672 ! S-acylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01925 name: (2S,5R)-5-hydroxylysine def: "A protein modification that effectively converts an L-lysine residue to (2S,5R)-5-hydroxylysine." [ChEBI:18040, PubMed:13375629, PubMed:15504407, PubMed:16101297, PubMed:2857489, RESID:AA0028] subset: PSI-MOD-slim synonym: "(2S,5R)-2,6-diamino-5-hydroxyhexanoic acid" EXACT RESID-systematic [] synonym: "(2S,5R)-5-hydroxylysine" EXACT RESID-name [] synonym: "2,6-bisazanyl-5-hydroxyhexanoic acid" EXACT RESID-alternate [] synonym: "2,6-diamino-2,3,4,6-tetradeoxyhexonic acid" EXACT RESID-alternate [] synonym: "5-hydroxylated L-lysine" EXACT PSI-MOD-alternate [] synonym: "5HyLys" EXACT PSI-MOD-label [] synonym: "alpha,epsilon-diamino-delta-hydroxycaproic acid" EXACT RESID-alternate [] synonym: "L-erythro-delta-hydroxylysine" EXACT RESID-alternate [] synonym: "MOD_RES (2S,5R)-5-hydroxylysine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 12 N 2 O 2" xref: MassAvg: "144.17" xref: MassMono: "144.089878" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00037 ! 5-hydroxy-L-lysine [Term] id: MOD:01926 name: 3-hydroxy-L-aspartic acid def: "A protein modification that effectively converts an L-aspartic acid residue to one of the diastereomeric 3-hydroxy-L-aspartic acid residues." [OMSSA:59, UniMod:35#D] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-hydroxybutanedioic acid" EXACT PSI-MOD-alternate [] synonym: "(2S)-3-hydroxyaspartic acid" EXACT PSI-MOD-alternate [] synonym: "3HyAsp" EXACT PSI-MOD-label [] synonym: "erythro-beta-hydroxylated L-aspartic acid" EXACT PSI-MOD-alternate [] synonym: "hydroxylationd" EXACT OMSSA-label [] synonym: "monohydroxylated aspartic acid" EXACT PSI-MOD-alternate [] synonym: "Oxidation" RELATED PSI-MS-label [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 4 H 5 N 1 O 4" xref: MassAvg: "131.09" xref: MassMono: "131.021858" xref: Origin: "D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00425 ! monohydroxylated residue is_a: MOD:00904 ! modified L-aspartic acid residue [Term] id: MOD:01927 name: O-glycosyl-L-tyrosine def: "A protein modification that effectively converts an L-tyrosine residue to O4'-glycosyltyrosine." [PubMed:18688235] subset: PSI-MOD-slim synonym: "OGlycoTyr" EXACT PSI-MOD-label [] xref: Origin: "Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00396 ! O-glycosylated residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01928 name: N-(L-isoaspartyl)-glycine def: "A protein modification that effectively crosslinks either an L-asparagine residue or an L-aspartic acid residue with a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine." [ChEBI:21479, PubMed:1826288, RESID:AA0126] comment: Cross-link 2. synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate [] synonym: "isoaspartyl glycine" EXACT RESID-alternate [] synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name [] synonym: "N-beta-aspartylglycine" EXACT RESID-alternate [] synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate [] synonym: "XLNK-4Asp-NGly" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 7 N 2 O 3" xref: MassAvg: "155.13" xref: MassMono: "155.045667" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00688 ! isopeptide crosslinked residues is_a: MOD:00908 ! modified glycine residue [Term] id: MOD:01929 name: N6-(L-isoaspartyl)-L-lysine def: "A protein modification that effectively crosslinks an either an L-asparagine residue or an L-aspartic acid residue with an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine." [ChEBI:21862, DeltaMass:0, PubMed:11000116, PubMed:6503713, RESID:AA0294] comment: Cross-link 2. synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate [] synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature [] synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate [] synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate [] synonym: "N-(beta-Aspartyl)-Lysine (Crosslink)" EXACT DeltaMass-label [] synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name [] synonym: "XLNK-4Asp-N6Lys" EXACT PSI-MOD-label [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 10 H 15 N 3 O 3" xref: MassAvg: "225.25" xref: MassMono: "225.111341" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00688 ! isopeptide crosslinked residues is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01930 name: D-aspartic acid (Asn) def: "A protein modification that effectively converts an L-asparagine residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190#ASN] synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic [] synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] synonym: "aminosuccinic acid" EXACT RESID-alternate [] synonym: "D-aspartic acid" EXACT RESID-name [] xref: DiffAvg: "0.98" xref: DiffFormula: "C 0 H -1 N -1 O 1" xref: DiffMono: "0.984016" xref: Formula: "C 4 H 5 N 1 O 3" xref: MassAvg: "115.09" xref: MassMono: "115.026943" xref: Origin: "N" xref: Source: "artifactual" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01942 ! D-aspartic acid [Term] id: MOD:01931 name: N6-phospho-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-phospho-L-lysine." [PubMed:20144148, RESID:AA0585] synonym: "(2S)-2-amino-6-(phosphonoamino)hexanoic acid" EXACT RESID-systematic [] synonym: "(2S)-2-azanyl-6-(phosphonoamino)hexanoic acid" EXACT RESID-alternate [] synonym: "6-phospholysine" EXACT RESID-alternate [] synonym: "N(6)-phosphonolysine" EXACT RESID-alternate [] synonym: "N(epsilon)-phospholysine" EXACT RESID-alternate [] synonym: "N(epsilon)-phosphonolysine" EXACT RESID-alternate [] synonym: "N(epsilon)-phosphonyllysine" EXACT RESID-alternate [] synonym: "N(epsilon)-phosphoryllysine" EXACT RESID-alternate [] synonym: "N6-phospho-L-lysine" EXACT RESID-name [] xref: DiffAvg: "79.98" xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1" xref: DiffMono: "79.966331" xref: Formula: "C 6 H 13 N 2 O 4 P 1" xref: MassAvg: "208.15" xref: MassMono: "208.061294" xref: Origin: "K" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01456 ! N-phosphorylated residue [Term] id: MOD:01932 name: L-lysinonorleucine def: "A protein modification that effectively cross-links two lysine residues with a carbon-nitrogen bond to form L-lysinonorleucine.." [PubMed:5117030, PubMed:5817620, PubMed:5879466, PubMed:6030254, RESID:AA0586] comment: Cross-link 2. synonym: "(2S)-2-amino-6-([(5S)-5-amino-5-carboxypentyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "(2S,2'S)-6,6'-iminobis(2-aminohexanoic acid)" EXACT RESID-alternate [] synonym: "6-(N6-L-lysino)-L-norleucine" EXACT RESID-alternate [] synonym: "L-lysinonorleucine" EXACT RESID-name [] synonym: "lysinonorleucine" EXACT RESID-alternate [] synonym: "lysinorleucine [misspelling]" EXACT RESID-alternate [] synonym: "lysylnorleucine" EXACT RESID-alternate [] synonym: "N6-[(5S)-5-amino-5-carboxypentyl]-L-lysine" EXACT RESID-alternate [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 12 H 21 N 3 O 2" xref: MassAvg: "239.32" xref: MassMono: "239.163377" xref: Origin: "K, K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:00946 ! crosslinked residues with loss of ammonia [Term] id: MOD:01933 name: desmosine def: "A protein modification that effectively cross-links four L-lysine residues to form desmosine." [ChEBI:37629, PubMed:13941623, PubMed:14109938, PubMed:14109939, PubMed:5839176, RESID:AA0587] comment: Cross-link 4. synonym: "4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium" EXACT RESID-systematic [] synonym: "6-[4-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine" EXACT RESID-alternate [] synonym: "desmosine" EXACT RESID-name [] xref: DiffAvg: "-58.15" xref: DiffFormula: "C 0 H -16 N -3 O 0" xref: DiffMono: "-58.134971" xref: FormalCharge: "1+" xref: Formula: "C 24 H 32 N 5 O 4" xref: MassAvg: "454.55" xref: MassMono: "454.244881" xref: Origin: "K, K, K, K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01425 ! pyridinyl ring crosslinked residues [Term] id: MOD:01934 name: isodesmosine def: "A protein modification that effectively cross-links four L-lysine residues to form isodesmosine." [ChEBI:37629, PubMed:13941623, PubMed:14109938, PubMed:14109939, PubMed:5839176, RESID:AA0588] comment: Cross-link 4. synonym: "2-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium" EXACT RESID-systematic [] synonym: "6-[2-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine" EXACT RESID-alternate [] synonym: "isodesmosine" EXACT RESID-name [] xref: DiffAvg: "-58.15" xref: DiffFormula: "C 0 H -16 N -3 O 0" xref: DiffMono: "-58.134971" xref: FormalCharge: "1+" xref: Formula: "C 24 H 32 N 5 O 4" xref: MassAvg: "454.55" xref: MassMono: "454.244881" xref: Origin: "K, K, K, K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue is_a: MOD:01425 ! pyridinyl ring crosslinked residues [Term] id: MOD:01935 name: O-glucosyl-L-hydroxylysine def: "modification from RESID" [PubMed:22045808, RESID:AA0589] synonym: "(D-glucopyranosyl)oxy-L-lysine" EXACT RESID-systematic [] synonym: "O-glucosyl-L-hydroxylysine" EXACT RESID-name [] xref: DiffAvg: "178.14" xref: DiffFormula: "C 6 H 10 N 0 O 6" xref: DiffMono: "178.047738" xref: Formula: "C 12 H 22 N 2 O 7" xref: MassAvg: "306.32" xref: MassMono: "306.142701" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01047 ! monohydroxylated lysine [Term] id: MOD:01936 name: N6-oleoyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-oleoyl-L-lysine." [PubMed:20942504, RESID:AA0590] synonym: "(2S)-2-amino-6-([(9Z)-octadec-9-enoyl]amino)hexanoic acid" EXACT RESID-systematic [] synonym: "N6-[(9Z)-1-oxo-9-octadecenyl]lysine" EXACT RESID-alternate [] synonym: "N6-oleoyl-L-lysine" EXACT RESID-name [] xref: DiffAvg: "264.45" xref: DiffFormula: "C 18 H 32 N 0 O 1" xref: DiffMono: "264.245316" xref: Formula: "C 24 H 44 N 2 O 2" xref: MassAvg: "392.63" xref: MassMono: "392.340279" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01937 name: N-palmitoyl-L-methionine def: "A protein modification that effectively converts an L-methionine residue to N-palmitoyl-L-methionine." [PubMed:20942504, RESID:AA0591] synonym: "(2S)-2-(hexadecanoylamino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "2-(hexadecanamido)-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate [] synonym: "LIPID N-palmitoyl methionine" EXACT UniProt-feature [] synonym: "N-(1-oxohexadecyl)methionine" EXACT RESID-alternate [] synonym: "N-palmitoyl-L-methionine" EXACT RESID-name [] xref: DiffAvg: "238.41" xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0" xref: DiffMono: "238.229666" xref: Formula: "C 21 H 40 N 1 O 2 S 1" xref: MassAvg: "370.62" xref: MassMono: "370.277976" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00913 ! modified L-methionine residue is_a: MOD:01685 ! alpha-amino palmitoylated residue [Term] id: MOD:01938 name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asn) def: "A protein modification that crosslinks an asparagine and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the release of ammonia." [RESID:AA0592#ASN] comment: Cross-link 2. synonym: "(2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid" EXACT RESID-name [] synonym: "aspartimide cysteine" EXACT RESID-alternate [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0" xref: DiffMono: "-17.026549" xref: Formula: "C 7 H 8 N 2 O 3 S 1" xref: MassAvg: "200.21" xref: MassMono: "200.025563" xref: Origin: "C, N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01945 ! 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid [Term] id: MOD:01939 name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asp) def: "A protein modification that crosslinks an aspartic acid and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the loss of a water molecule." [RESID:AA0592#ASP] comment: Cross-link 2. synonym: "(2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid" EXACT RESID-systematic [] synonym: "2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid" EXACT RESID-name [] synonym: "aspartimide cysteine" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 7 H 8 N 2 O 3 S 1" xref: MassAvg: "200.21" xref: MassMono: "200.025563" xref: Origin: "C, D" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01945 ! 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid [Term] id: MOD:01940 name: 2-(2-aminosuccinimidyl)pentanedioic acid (Asn) def: "A protein modification that crosslinks an asparagine and the following glutamic acid residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the release of ammonia." [RESID:AA0593#ASN] comment: Cross-link 2. synonym: "(4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "2-(2-aminosuccinimidyl)pentanedioic acid" EXACT RESID-name [] synonym: "aspartimide glutamic acid" EXACT RESID-alternate [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 9 H 10 N 2 O 5" xref: MassAvg: "226.19" xref: MassMono: "226.058971" xref: Origin: "E, N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01946 ! 2-(2-aminosuccinimidyl)pentanedioic acid [Term] id: MOD:01941 name: 2-(2-aminosuccinimidyl)pentanedioic acid (Asp) def: "A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the loss of a water molecule." [RESID:AA0593#ASP] comment: Cross-link 2. synonym: "(4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "2-(2-aminosuccinimidyl)pentanedioic acid" EXACT RESID-name [] synonym: "aspartimide glutamic acid" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 9 H 10 N 2 O 5" xref: MassAvg: "226.19" xref: MassMono: "226.058971" xref: Origin: "D, E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:01946 ! 2-(2-aminosuccinimidyl)pentanedioic acid [Term] id: MOD:01942 name: D-aspartic acid def: "A protein modification that effectively converts a source amino acid residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190] synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic [] synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate [] synonym: "aminosuccinic acid" EXACT RESID-alternate [] synonym: "D-aspartic acid" EXACT RESID-name [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 4 H 5 N 1 O 3" xref: MassAvg: "115.09" xref: MassMono: "115.026943" xref: Origin: "X" xref: Source: "artifactual" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01943 name: pyrrolidione ring crosslinked residues def: "A protein modification that crosslinks two adjacent residues by formation of a pyrrolidione ring." [PubMed:18688235] is_a: MOD:00033 ! crosslinked residues [Term] id: MOD:01944 name: 2-aminosuccinimide ring crosslinked residues def: "A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following residue." [PubMed:18688235] comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. subset: PSI-MOD-slim xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00033 ! crosslinked residues is_a: MOD:00859 ! modified residue that can arise from different natural residues [Term] id: MOD:01945 name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid def: "A protein modification that forms (2-aminosuccinimidyl)-3-sulfanylpropanoic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following cysteine residue." [PubMed:18688235] comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 6 N 2 O 3" xref: MassAvg: "154.13" xref: MassMono: "154.037842" xref: Origin: "C, X" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues [Term] id: MOD:01946 name: 2-(2-aminosuccinimidyl)pentanedioic acid def: "A protein modification that forms (2-aminosuccinimidyl)pentanedioicacid by crosslinking either an aspartic acid residue or an asparagine residue with the following glutamic acid\n residue." [PubMed:18688235] comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 6 H 6 N 2 O 3" xref: MassAvg: "154.13" xref: MassMono: "154.037842" xref: Origin: "E, X" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues [Term] id: MOD:01947 name: O-(L-isoaspartyl)-L-threonine (cross-link) def: "A protein modification that effectively cross-links an L-threonine residue and an L-aspartic acid residue with an ester bond to form O-(L-isoaspartyl)-L-threonine." [PubMed:17157318, PubMed:8706862, RESID:AA0525#TDX] comment: Cross-link 2. synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate [] synonym: "CROSSLNK isoaspartyl threonine ester (Thr-Asp)" EXACT UniProt-feature [] synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate [] synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1" xref: DiffMono: "-18.010565" xref: Formula: "C 8 H 10 N 2 O 4" xref: MassAvg: "198.18" xref: MassMono: "198.064057" xref: Origin: "D, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00885 ! ester crosslinked residues is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01978 ! O-(L-isoaspartyl)-L-threonine [Term] id: MOD:01948 name: labionin def: "A protein modification that effectively cross-links an L-cysteine residue and two L-serine residues by a thioether bond and a carbon-carbon bond to form labionin." [PubMed:20082397, RESID:AA0594] comment: Cross-link 3. synonym: "(2S,4S)-2,4-diamino-2-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)methyl]pentanedioic acid" EXACT RESID-systematic [] synonym: "(2S,4S,8R)-2,4,8-triamino-4-carboxy-6-thianonanedioic acid" EXACT RESID-alternate [] synonym: "(2S,4S,8R)-labionin" EXACT RESID-alternate [] synonym: "labionin" EXACT RESID-name [] xref: DiffAvg: "-36.03" xref: DiffFormula: "C 0 H -4 N 0 O -2 S 0" xref: DiffMono: "-36.021129" xref: Formula: "C 9 H 11 N 3 O 3 S 1" xref: MassAvg: "241.26" xref: MassMono: "241.052112" xref: Origin: "C, S, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01993 ! beta-carbon thioether crosslinked residues [Term] id: MOD:01949 name: coelenterazine def: "A protein modification that effectively cross-links a phenylalanine and two tyrosine residues to form coelenterazine." [ChEBI:2311, PubMed:10830969, PubMed:11572972, PubMed:19833098, RESID:AA0595] comment: Cross-link 3. synonym: "8-benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one" EXACT RESID-systematic [] synonym: "coelenterazine" EXACT RESID-name [] synonym: "Oplophorus luciferin" EXACT RESID-alternate [] xref: DiffAvg: "-50.06" xref: DiffFormula: "C -1 H -6 N 0 O -2" xref: DiffMono: "-50.036779" xref: Formula: "C 26 H 21 N 3 O 3" xref: MassAvg: "423.47" xref: MassMono: "423.158292" xref: Origin: "F, Y, Y" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:00033 ! crosslinked residues is_a: MOD:00914 ! modified L-phenylalanine residue is_a: MOD:00919 ! modified L-tyrosine residue [Term] id: MOD:01950 name: L-isoglutamyl histamine def: "A protein modification that effectively converts an L-glutamine residue to L-isoglutamyl histamine." [PubMed:23022564, RESID:AA0596] synonym: "(2S)-2-amino-5-([2-(1H-imidazol-5-yl)ethyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(gamma-glutamyl)histamine" EXACT RESID-alternate [] synonym: "L-isoglutamyl histamine" EXACT RESID-name [] xref: DiffAvg: "94.12" xref: DiffFormula: "C 5 H 6 N 2 O 0" xref: DiffMono: "94.053098" xref: Formula: "C 10 H 14 N 4 O 2" xref: MassAvg: "222.25" xref: MassMono: "222.111676" xref: Origin: "Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00907 ! modified L-glutamine residue [Term] id: MOD:01951 name: O-(L-isoglutamyl)-L-serine (Gln-Ser) def: "A protein modification that effectively crosslinks an L-glutamine residue and an L-serine residue by an ester bond and releasing ammonia to form O-(L-isoglutamyl)-L-serine." [PubMed:17051152, RESID:AA0597#QSX] comment: Cross-link 2. synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate [] synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name [] synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 8 H 10 N 2 O 4" xref: MassAvg: "198.18" xref: MassMono: "198.064057" xref: Origin: "Q, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:00946 ! crosslinked residues with loss of ammonia is_a: MOD:01977 ! O-(L-isoglutamyl)-L-serine [Term] id: MOD:01952 name: O-(L-isoglutamyl)-L-threonine (cross-link) def: "A protein modification that effectively cross-links an L-threonine residue and an L-glutamine residue with an ester bond releasing ammonia to form O-(L-isoglutamyl)-L-threonine." [PubMed:17051152, RESID:AA0536#TQX] comment: Cross-link 2. synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate [] synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate [] synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate [] synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate [] xref: DiffAvg: "-17.03" xref: DiffFormula: "C 0 H -3 N -1 O 0" xref: DiffMono: "-17.026549" xref: Formula: "C 9 H 12 N 2 O 4" xref: MassAvg: "212.20" xref: MassMono: "212.079707" xref: Origin: "Q, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00885 ! ester crosslinked residues is_a: MOD:00907 ! modified L-glutamine residue is_a: MOD:01979 ! O-(L-isoglutamyl)-L-threonine [Term] id: MOD:01953 name: tetrakis-L-cysteinyl tetrairon octanitrosyl def: "A protein modification that effectively converts four L-cysteine residues and a four-iron cluster to tetrakis-L-cysteinyl tetrairon octanitrosyl." [PubMed:21182249, RESID:AA0599] comment: Cross-link 4. xref: DiffAvg: "459.40" xref: DiffFormula: "C 0 Fe 4 H -4 N 8 O 8 S 0" xref: DiffMono: "459.692359" xref: Formula: "C 12 Fe 4 H 16 N 12 O 12 S 4" xref: MassAvg: "871.95" xref: MassMono: "871.729098" xref: Origin: "C, C, C, C" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00738 ! iron containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01954 name: dehydroalanine (Sec) def: "A protein modification that effectively converts an L-selenocysteine residue to dehydroalanine." [ChEBI:17123, PubMed:10220322, PubMed:12781460, PubMed:1547888, PubMed:1815586, PubMed:20805503, PubMed:21420488, PubMed:22031445, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181] synonym: "2,3-didehydroalanine" EXACT RESID-alternate [] synonym: "2-aminoacrylic acid" EXACT RESID-alternate [] synonym: "2-aminopropenoic acid" EXACT RESID-systematic [] synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate [] synonym: "anhydroserine" EXACT RESID-alternate [] synonym: "dehydroalanine" EXACT RESID-name [] synonym: "Dha" EXACT RESID-alternate [] xref: DiffAvg: "-80.99" xref: DiffFormula: "C 0 H -2 N 0 O 0 Se -1" xref: DiffMono: "-81.932171" xref: Formula: "C 3 H 3 N 1 O 1" xref: MassAvg: "69.06" xref: MassMono: "69.021464" xref: Origin: "U" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01158 ! modified L-selenocysteine residue is_a: MOD:01168 ! dehydroalanine [Term] id: MOD:01955 name: L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide def: "modification from RESID" [PubMed:21499260, RESID:AA0600] comment: Cross-link 7. synonym: "4Mn-Ca-5O cluster" EXACT RESID-alternate [] synonym: "L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide" EXACT RESID-name [] synonym: "mu2-alaninato-1kappaO(1),3kappaO(1')-mu2-aspartato-1kappaO(4),5kappaO(4')-mu2-aspartato-2kappaO(4),3kappaO(4')-mu2-glutamato-3kappaO(5),4kappaO(5')-mu2-glutamato-4kappaO(5),5kappaO(5')-mu-glutamato-2kappaO(5)-mu-histidino-2kappaN(tau)-mu4-oxido-1:2:4:5kappa(4)O-tri-mu3-oxido-1:2:3kappa(3)O;1:3:4kappa(3)O;2:3:4kappa(3)O;mu-oxido-4:5kappa(2)O-calciumtetramanganese" EXACT RESID-systematic [] synonym: "photosystem II catalytic cluster" EXACT RESID-alternate [] xref: DiffAvg: "333.78" xref: DiffFormula: "C 0 Ca 1 H -6 Mn 4 N 0 O 5" xref: DiffMono: "333.642394" xref: Formula: "C 32 Ca 1 H 38 Mn 4 N 9 O 23" xref: MassAvg: "1176.53" xref: MassMono: "1175.922825" xref: Origin: "A, D, D, E, E, E, H" xref: Source: "natural" xref: TermSpec: "C-term" is_a: MOD:00740 ! manganese containing modified residue is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:00904 ! modified L-aspartic acid residue is_a: MOD:00906 ! modified L-glutamic acid residue is_a: MOD:00909 ! modified L-histidine residue is_a: MOD:01482 ! calcium containing modified residue [Term] id: MOD:01956 name: (3R)-3-hydroxy-L-arginine def: "A protein modification that effectively converts an L-arginine residue to (3R)-3-hydroxy-L-arginine." [PubMed:10094780, PubMed:23103944, PubMed:786730, RESID:AA0601] synonym: "(2S,3R)-2-amino-5-[(diaminomethylidene)amino]-3-hydroxypentanoic acid" EXACT RESID-systematic [] synonym: "(3R)-3-hydroxy-L-arginine" EXACT RESID-name [] synonym: "2-amino-5-(carbamimidamido)-3-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-amino-5-[(aminoiminomethyl)amino]-3-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate [] synonym: "2-amino-5-guanidino-3-hydroxypentanoic acid" EXACT RESID-alternate [] synonym: "beta-hydroxyarginine" EXACT RESID-alternate [] synonym: "C(beta)-hydroxyarginine" EXACT RESID-alternate [] synonym: "MOD_RES (3R)-3-hydroxyarginine" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 6 H 12 N 4 O 2" xref: MassAvg: "172.19" xref: MassMono: "172.096026" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00682 ! hydroxylated arginine [Term] id: MOD:01957 name: 2-hydroxyproline def: "A protein modification that effectively converts an L-proline residue to 2-hydroxyproline." [PubMed:23385463, RESID:AA0602] synonym: "(2R)-2-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic [] synonym: "2-hydroxyproline" EXACT RESID-name [] synonym: "2-oxidanylpyrrolidine-2-carboxylic acid" EXACT RESID-alternate [] synonym: "alpha-hydroxyproline" EXACT RESID-alternate [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 7 N 1 O 2" xref: MassAvg: "113.12" xref: MassMono: "113.047678" xref: Origin: "P" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01024 ! monohydroxylated proline [Term] id: MOD:01958 name: bis-L-cysteinyl bisglutathion-S-yl diiron disulfide def: "A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bisglutathion-S-yl diiron disulfide." [PubMed:17121859, RESID:AA0603] comment: Cross-link 2. synonym: "bis-L-cysteinyl bisglutathion-S-yl diiron disulfide" EXACT RESID-name [] synonym: "di-mu-sulfido-bis(cysteinato)-1kappaS,2kappaS-bis(glutathionato)-1kappaS,2kappaS-diiron" EXACT RESID-systematic [] synonym: "mitochondrial glutaredoxin 2 dimer iron-sulfur cluster" EXACT RESID-alternate [] synonym: "plant glutaredoxin C1 dimer iron-sulfur cluster" EXACT RESID-alternate [] xref: DiffAvg: "786.42" xref: DiffFormula: "C 20 Fe 2 H 30 N 6 O 12 S 4" xref: DiffMono: "785.950329" xref: Formula: "C 26 Fe 2 H 40 N 8 O 14 S 6" xref: MassAvg: "992.70" xref: MassMono: "991.968699" xref: Origin: "C, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01959 name: tris-L-cysteinyl L-glutamato tetrairon tetrasulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-glutamic acid and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamato tetrairon tetrasulfide." [PubMed:21167158, RESID:AA0604] comment: Cross-link 4. synonym: "tris-L-cysteinyl L-glutamato tetrairon tetrasulfide" EXACT RESID-name [] synonym: "tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutamato-4kappaO(5),4kappaO(5')-tetrairon" EXACT RESID-systematic [] xref: DiffAvg: "347.59" xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" xref: DiffMono: "347.596734" xref: Formula: "C 14 Fe 4 H 18 N 4 O 6 S 7" xref: MassAvg: "786.12" xref: MassMono: "785.666881" xref: Origin: "C, C, C, E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01960 name: tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide def: "A protein modification that effectively converts three L-cysteine residues, an L-glutamine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide." [PubMed:11796730, RESID:AA0605] comment: Cross-link 4. synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature [] synonym: "tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide" EXACT RESID-name [] synonym: "tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutaminato-4kappaN(5)-tetrairon" EXACT RESID-systematic [] xref: DiffAvg: "347.59" xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4" xref: DiffMono: "347.596734" xref: Formula: "C 14 Fe 4 H 19 N 5 O 5 S 7" xref: MassAvg: "785.14" xref: MassMono: "784.682866" xref: Origin: "C, C, C, Q" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00739 ! iron-sulfur cluster containing modification is_a: MOD:00905 ! modified L-cysteine residue is_a: MOD:00907 ! modified L-glutamine residue [Term] id: MOD:01961 name: O-(L-isoglutamyl)-L-threonine (THR) def: "OBSOLETE because redundant and identical to MOD:01785. Remap to MOD:01785." [PubMed:16618936, PubMed:17051152, PubMed:17687277, PubMed:18555071, RESID:AA0536#THR] synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate [] synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate [] synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate [] synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate [] xref: DiffAvg: "129.12" xref: DiffFormula: "C 5 H 7 N 1 O 3" xref: DiffMono: "129.042593" xref: Formula: "C 9 H 14 N 2 O 5" xref: MassAvg: "230.22" xref: MassMono: "230.090272" xref: Origin: "T" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01962 name: N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine def: "A protein modification that effectively converts an L-asparagine residue to N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine." [PubMed:12186869, PubMed:19236052, RESID:AA0606] synonym: "(2S)-2-amino-4-[(2,4-diacetylamino-2,4,6-trideoxy-beta-D-glucopyranosyl)amino]-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "DABA" EXACT RESID-alternate [] synonym: "DATDH" EXACT RESID-alternate [] synonym: "DiNAcBac" EXACT RESID-alternate [] synonym: "N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine" EXACT RESID-name [] synonym: "N4-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-asparagine" EXACT RESID-alternate [] synonym: "N4-[N,N-diacetylbacillosaminyl]asparagine" EXACT RESID-alternate [] synonym: "N4-[N2,N4-diacetylbacillosaminyl]asparagine" EXACT RESID-alternate [] xref: DiffAvg: "228.25" xref: DiffFormula: "C 10 H 16 N 2 O 4" xref: DiffMono: "228.111007" xref: Formula: "C 14 H 22 N 4 O 6" xref: MassAvg: "342.35" xref: MassMono: "342.153934" xref: Origin: "N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: MOD:01963 name: O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine." [PubMed:23030644, RESID:AA0607] synonym: "(2S)-2-amino-4-[(2,4-diacetamido-2,4,6-trideoxy-beta-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic [] synonym: "DABA" EXACT RESID-alternate [] synonym: "DATDH" EXACT RESID-alternate [] synonym: "DiNAcBac" EXACT RESID-alternate [] synonym: "O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine" EXACT RESID-name [] synonym: "O-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-serine" EXACT RESID-alternate [] synonym: "O-[N,N-diacetylbacillosaminyl]serine" EXACT RESID-alternate [] synonym: "O-[N2,N4-diacetylbacillosaminyl]serine" EXACT RESID-alternate [] xref: DiffAvg: "228.25" xref: DiffFormula: "C 10 H 16 N 2 O 4" xref: DiffMono: "228.111007" xref: Formula: "C 13 H 21 N 3 O 6" xref: MassAvg: "315.33" xref: MassMono: "315.143035" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine [Term] id: MOD:01964 name: O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine def: "A protein modification that effectively converts an L-serine residue to O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine." [PubMed:17804791, RESID:AA0608] synonym: "(2S)-2-amino-3-[(2-acetamido-4-glycerylamino-2,4,6-trideoxy-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic [] synonym: "GATDH" EXACT RESID-alternate [] synonym: "O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucopyranosyl)-L-serine" EXACT RESID-alternate [] synonym: "O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine" EXACT RESID-name [] synonym: "O-(N2-acetyl-N4-glycerylbacillosaminyl)-L-serine" EXACT RESID-alternate [] xref: DiffAvg: "274.27" xref: DiffFormula: "C 11 H 18 N 2 O 6" xref: DiffMono: "274.116486" xref: Formula: "C 14 H 23 N 3 O 8" xref: MassAvg: "361.35" xref: MassMono: "361.148515" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00002 ! O-glycosyl-L-serine [Term] id: MOD:01965 name: 2xC(13),3x(2)H labeled N6-acetyl-L-lysine def: "A protein modification that effectively converts an L-lysine residue to 2xC(13),3x(2)H labeled N6-acetyl-L-lysine." [PubMed:18688235] synonym: "Acetate labeling reagent (K) (heavy form, +5amu)" EXACT PSI-MOD-alternate [] synonym: "COFRADIC heavy acetyl 13C2 2H3" EXACT PSI-MOD-alternate [] xref: DiffAvg: "47.04" xref: DiffFormula: "(13)C 2 (1)H -1 (2)H 3 O 1" xref: DiffMono: "47.036105" xref: Formula: "(12)C 6 (13)C 2 (1)H 11 (2)H 3 N 2 O 2" xref: MassAvg: "175.13" xref: MassMono: "175.131068" xref: Origin: "K" xref: Source: "artifact" xref: TermSpec: "none" is_a: MOD:00064 ! N6-acetyl-L-lysine is_a: MOD:01428 ! (13)C isotope tagged reagent is_a: MOD:01431 ! (2)H deuterium tagged reagent [Term] id: MOD:01966 name: L-methionine (R)-sulfoxide def: "OBSOLETE because redundant and identical to MOD:00720. Remap to MOD:00720." [ChEBI:45764, PubMed:21406390, PubMed:22116028, PubMed:23911929, RESID:AA0581] synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic [] synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate [] synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name [] synonym: "MOD_RES Methionine (R)-sulfoxide" EXACT UniProt-feature [] xref: DiffAvg: "16.00" xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0" xref: DiffMono: "15.994915" xref: Formula: "C 5 H 9 N 1 O 2 S 1" xref: MassAvg: "147.19" xref: MassMono: "147.035400" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "none" is_obsolete: true [Term] id: MOD:01967 name: omega-N-(N-acetylamino)glucosyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to omega-N-(N-acetylamino)glucosyl-L-arginine." [PubMed:23955153, RESID:AA0609] synonym: "(2S)-2-amino-5-[(amino[(2-N-acetylamino-2-deoxy-D-glucopyranosyl)amino]methylidene)amino]pentanoic acid" EXACT RESID-systematic [] synonym: "N(omega)-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] synonym: "N(omega)-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] synonym: "N(omega)-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate [] synonym: "NG-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] synonym: "NG-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] synonym: "NG-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate [] synonym: "omega-N-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] synonym: "omega-N-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate [] synonym: "omega-N-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate [] synonym: "omega-N-(N-acetylamino)glucosyl-L-arginine" EXACT RESID-name [] xref: DiffAvg: "203.19" xref: DiffFormula: "C 8 H 13 N 1 O 5" xref: DiffMono: "203.079373" xref: Formula: "C 14 H 25 N 5 O 6" xref: MassAvg: "359.38" xref: MassMono: "359.180484" xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00448 ! N-acetylaminoglucosylated residue is_a: MOD:01980 ! omega-N-glycosyl-L-arginine [Term] id: MOD:01968 name: (2R,3R,2'R)-3-methyllanthionine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2R,3R,2'R)-3-methyllanthionine." [PubMed:23314913, RESID:AA0610] comment: Cross-link 2. synonym: "(2R,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT RESID-systematic [] synonym: "(2R,3R,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate [] synonym: "(2R,3R,2'R)-3-methyllanthionine" EXACT RESID-name [] synonym: "(2R,3R,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT RESID-alternate [] synonym: "(2R,3R,6R)-3-methyllanthionine" EXACT RESID-alternate [] synonym: "2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid" EXACT RESID-alternate [] synonym: "3-methyl-L,L-lanthionine" EXACT RESID-alternate [] synonym: "cysteine-3-L-butyrine thioether" EXACT RESID-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 7 H 10 N 2 O 2 S 1" xref: MassAvg: "186.23" xref: MassMono: "186.046299" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:01981 ! 3-methyllanthionine [Term] id: MOD:01969 name: S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine." [PubMed:9398217, RESID:AA0611] synonym: "(2S)-2-amino-5-([(2R)-1-([2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-oxoethyl]amino)-1-oxo-3-sulfanylpropan-2-yl]amino)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "ACT_SITE S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine intermediate" EXACT UniProt-feature [] synonym: "S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine" EXACT RESID-name [] synonym: "S-(glutathion-1-yl)-L-cysteine" EXACT RESID-alternate [] xref: DiffAvg: "289.31" xref: DiffFormula: "C 10 H 15 N 3 O 5 S 1" xref: DiffMono: "289.073242" xref: Formula: "C 13 H 20 N 4 O 6 S 2" xref: MassAvg: "392.44" xref: MassMono: "392.082426" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00860 ! sulfur containing modified residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01970 name: 5-glutamyl glutamic acid def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl glutamic acid, forming an isopeptide bond with a free glutamic acid." [PubMed:10747868, PubMed:15525938, PubMed:1680872, PubMed:23434852, RESID:AA0612, UniMod:450] synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanedioic acid" EXACT RESID-systematic [] synonym: "(2S)-2-[(4S)-4-amino-4-carboxybutanamido]pentanedioic acid" EXACT RESID-alternate [] synonym: "2-([4-azanyl-4-carboxybutanoyl]azanyl)pentanedioic acid" EXACT RESID-alternate [] synonym: "5-glutamyl glutamic acid" EXACT RESID-name [] synonym: "gamma-glutamylglutamate" EXACT RESID-alternate [] synonym: "Glu" RELATED UniMod-interim [] synonym: "isoglutamyl glutamic acid" EXACT RESID-alternate [] synonym: "isoglutamyl monoglutamic acid" EXACT RESID-alternate [] synonym: "MOD_RES 5-glutamyl glutamate" EXACT UniProt-feature [] synonym: "monoglutamyl" RELATED UniMod-description [] synonym: "N alpha -(gamma-Glutamyl)-Glu" EXACT DeltaMass-label [] synonym: "N-(gamma-L-glutamyl)-L-glutamic acid" EXACT RESID-alternate [] xref: DiffAvg: "129.12" xref: DiffFormula: "C 5 H 7 N 1 O 3" xref: DiffMono: "129.042593" xref: Formula: "C 10 H 14 N 2 O 6" xref: MassAvg: "258.23" xref: MassMono: "258.085186" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid [Term] id: MOD:01971 name: 5-glutamyl N2-ornithine def: "A protein modification that effectively converts an L-glutamic acid residue to N2-ornithine." [PubMed:23434852, RESID:AA0613] synonym: "(2S)-5-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanoic acid" EXACT RESID-alternate [] synonym: "(2S)-5-amino-2-[(4S)-4-amino-4-carboxybutanamido]pentanoic acid" EXACT RESID-systematic [] synonym: "4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-ketovaleric acid" EXACT RESID-alternate [] synonym: "4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-oxopentanoic acid" EXACT RESID-alternate [] synonym: "5-glutamyl N2-ornithine" EXACT RESID-name [] synonym: "gamma-glutamylornithine" EXACT RESID-alternate [] synonym: "MOD_RES 5-glutamyl N2-ornithine" EXACT UniProt-feature [] synonym: "N2-(gamma-glutamyl)ornithine" EXACT RESID-alternate [] synonym: "N2-(L-isoglutamyl)-L-ornithine" EXACT RESID-alternate [] xref: DiffAvg: "114.15" xref: DiffFormula: "C 5 H 10 N 2 O 1" xref: DiffMono: "114.079313" xref: Formula: "C 10 H 17 N 3 O 4" xref: MassAvg: "243.26" xref: MassMono: "243.121906" xref: Origin: "E" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00674 ! amidated residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01972 name: 5-glutamyl coenzyme A thioester def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl coenzyme A thioester." [PubMed:16253988, PubMed:20977214, PubMed:7915164, RESID:AA0614] synonym: "(2S)-2-amino-5-(2-[([3-([(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanoyl]-amino)-propanoyl]-amino)-ethyl]-sulfanyl)-5-oxopentanoic acid" EXACT RESID-alternate [] synonym: "(2S)-2-amino-5-([2-(3-[(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanamido]-propanamido)-ethyl]-sulfanyl)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "5-glutamyl 4-[(3'-phospho-adenosyl-5'-diphosphoryl)oxy]pantetheine thioester" EXACT RESID-alternate [] synonym: "5-glutamyl coenzyme A thioester" EXACT RESID-name [] synonym: "5-glutamyl coenzyme A thioester intermediate" EXACT UniProt-feature [] xref: DiffAvg: "749.52" xref: DiffFormula: "C 21 H 34 N 7 O 15 P 3 S 1" xref: DiffMono: "749.104644" xref: Formula: "C 26 H 41 N 8 O 18 P 3 S 1" xref: MassAvg: "878.63" xref: MassMono: "878.147237" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00860 ! sulfur containing modified residue is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:00906 ! modified L-glutamic acid residue [Term] id: MOD:01973 name: N6-(3-phosphoglyceryl)-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-(3-phosphoglyceryl)-L-lysine." [PubMed:23908237, RESID:AA0615] synonym: "(2S)-2-amino-6-([(2R)-2-hydroxy-3-(phosphonooxy)propanoyl]amino)hexanoic acid" EXACT RESID-alternate [] synonym: "(2S)-2-amino-6-[(2R)-2-hydroxy-3-(phosphonooxy)propanamido]hexanoic acid" EXACT RESID-systematic [] synonym: "3-phosphoglyceryl-lysine" EXACT RESID-alternate [] synonym: "N6-(3-phosphoglyceryl)-L-lysine" EXACT RESID-name [] xref: DiffAvg: "168.04" xref: DiffFormula: "C 3 H 5 N 0 O 6 P 1" xref: DiffMono: "167.982375" xref: Formula: "C 9 H 17 N 2 O 7 P 1" xref: MassAvg: "296.22" xref: MassMono: "296.077338" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00861 ! phosphorus containing modified residue is_a: MOD:01875 ! N6-acylated L-lysine [Term] id: MOD:01974 name: S-methyl-L-methionine def: "A protein modification that effectively converts an L-methionine residue to S-methyl-L-methionine." [ChEBI:17728, PubMed:23532849, RESID:AA0616] synonym: "(2S)-2-amino-4-(dimethylsulfonio)butanoate" EXACT RESID-alternate [] synonym: "(3S)-(3-amino-3-carboxypropyl)dimethylsulfanium" EXACT RESID-systematic [] synonym: "[(3S)-3-amino-3-carboxypropyl](dimethyl)sulfonium" EXACT RESID-alternate [] synonym: "S-methyl-L-methionine" EXACT RESID-name [] synonym: "S-methylmethionine" EXACT RESID-alternate [] synonym: "S-methylmethioninium" EXACT RESID-alternate [] synonym: "vitamin U" EXACT RESID-alternate [] xref: DiffAvg: "15.03" xref: DiffFormula: "C 1 H 3 N 0 O 0 S 0" xref: DiffMono: "15.022927" xref: FormalCharge: "1+" xref: Formula: "C 6 H 12 N 1 O 1 S 1" xref: MassAvg: "146.23" xref: MassMono: "146.063411" xref: Origin: "M" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00716 ! methylated methionine [Term] id: MOD:01975 name: S-poly(3-hydroxybutyrate)-L-cysteine def: "A protein modification that effectively converts an L-cysteine residue to S-(poly-3-hydroxybutyrate)-L-cysteine." [PubMed:19711985, PubMed:9888824, RESID:AA0617] synonym: "(alpha)-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-(omega)-[(3R)-3-hydroxybutanoyl]-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)" EXACT RESID-systematic [] synonym: "S-poly(3-hydroxybutanoate)cysteine" EXACT RESID-alternate [] synonym: "S-poly(3-hydroxybutanoic acid)cysteine" EXACT RESID-alternate [] synonym: "S-poly(3-hydroxybutyrate)-L-cysteine" EXACT RESID-name [] synonym: "S-poly(3-hydroxybutyrate)cysteine" EXACT RESID-alternate [] synonym: "S-poly(3-hydroxybutyric acid)cysteine" EXACT RESID-alternate [] synonym: "S-poly(beta-hydroxybutyrate)cysteine" EXACT RESID-alternate [] synonym: "S-poly[(R)-3-hydroxybutyrate]cysteine" EXACT RESID-alternate [] xref: DiffAvg: "172.18" xref: DiffFormula: "C 8 H 12 N 0 O 4 S 0" xref: DiffMono: "172.073559" xref: Formula: "C 11 H 17 N 1 O 5 S 1" xref: MassAvg: "275.32" xref: MassMono: "275.082744" xref: Origin: "C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00672 ! S-acylated residue is_a: MOD:00905 ! modified L-cysteine residue [Term] id: MOD:01976 name: O3-(poly-3-hydroxybutyrate)-L-serine def: "A protein modification that effectively converts an L-serine residue to O3-(poly-3-hydroxybutyrate)-L-serine." [PubMed:17659252, PubMed:20004640, RESID:AA0618] subset: PSI-MOD-slim synonym: "(2S)-2-amino-3-[([(3R)-3-hydroxybutanoyl]oxy)-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)]propanoic acid" EXACT RESID-systematic [] synonym: "O3-(poly-3-hydroxybutyrate)-L-serine" EXACT RESID-name [] synonym: "O3-poly(3-hydroxybutanoate)serine" EXACT RESID-alternate [] synonym: "O3-poly(3-hydroxybutanoic acid)serine" EXACT RESID-alternate [] synonym: "O3-poly(3-hydroxybutyrate)serine" EXACT RESID-alternate [] synonym: "O3-poly(3-hydroxybutyric acid)serine" EXACT RESID-alternate [] synonym: "O3-poly(beta-hydroxybutyrate)serine" EXACT RESID-alternate [] synonym: "O3-poly[(R)-3-hydroxybutyrate]serine" EXACT RESID-alternate [] xref: DiffAvg: "172.18" xref: DiffFormula: "C 8 H 12 N 0 O 4" xref: DiffMono: "172.073559" xref: Formula: "C 11 H 17 N 1 O 6" xref: MassAvg: "259.26" xref: MassMono: "259.105587" xref: Origin: "S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00671 ! O-acylated residue is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01977 name: O-(L-isoglutamyl)-L-serine def: "A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-serine residue by an ester bond to form O-(L-isoglutamyl)-L-serine." [PubMed:17051152, RESID:AA0597] comment: Cross-link 2. synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate [] synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name [] synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 8 H 10 N 2 O 4" xref: MassAvg: "198.18" xref: MassMono: "198.064057" xref: Origin: "S, X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:00885 ! ester crosslinked residues is_a: MOD:00916 ! modified L-serine residue [Term] id: MOD:01978 name: O-(L-isoaspartyl)-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using either free L-asparagine and releasing ammonia or using a peptidyl L-aspartic acid residue and releasing water." [PubMed:8706862, RESID:AA0525] comment: This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate [] synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate [] synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 8 H 12 N 2 O 5" xref: MassAvg: "216.19" xref: MassMono: "216.074621" xref: Origin: "T, X" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01979 name: O-(L-isoglutamyl)-L-threonine def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia, or using a peptidyl L-glutamine and releasing ammonia." [PubMed:8706862, RESID:AA0536] comment: This is not an ester cross-link of peptides [JSG]. synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic [] synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate [] synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate [] synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate [] synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name [] synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate [] xref: DiffAvg: "none" xref: DiffFormula: "none" xref: DiffMono: "none" xref: Formula: "C 9 H 14 N 2 O 5" xref: MassAvg: "230.22" xref: MassMono: "230.090272" xref: Origin: "T, X" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:00859 ! modified residue that can arise from different natural residues is_a: MOD:00917 ! modified L-threonine residue [Term] id: MOD:01980 name: omega-N-glycosyl-L-arginine def: "A protein modification that effectively converts an L-arginine residue to N4-glycosyl-arginine." [PubMed:15279557, PubMed:8521968, PubMed:9536051, RESID:AA0327, UniMod:41#R] synonym: "(2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid" EXACT RESID-systematic [] synonym: "Hex" RELATED PSI-MS-label [] synonym: "Hexose" RELATED UniMod-description [] synonym: "NG-beta-D-glucosylarginine" EXACT RESID-alternate [] synonym: "omega-N-(beta-D-glucosyl)-L-arginine" EXACT RESID-alternate [] synonym: "omega-N-glucosyl-L-arginine" EXACT RESID-name [] synonym: "omega-N-glycosyl-L-arginine" EXACT RESID-alternate [] xref: Origin: "R" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00006 ! N-glycosylated residue is_a: MOD:00902 ! modified L-arginine residue [Term] id: MOD:01981 name: 3-methyllanthionine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 3-methyllanthionine with unresolved stereospecificity." [PubMed:18688235] comment: Cross-link 2. synonym: "2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT PSI-MOD-alternate [] synonym: "2-amino-3-([2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT PSI-MOD-alternate [] synonym: "2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT PSI-MOD-alternate [] synonym: "2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid" EXACT PSI-MOD-alternate [] synonym: "3-methyllanthionine" EXACT PSI-MOD-alternate [] synonym: "cysteine-3-L-butyrine thioether" EXACT PSI-MOD-alternate [] xref: DiffAvg: "-18.02" xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0" xref: DiffMono: "-18.010565" xref: Formula: "C 7 H 10 N 2 O 2 S 1" xref: MassAvg: "186.23" xref: MassMono: "186.046299" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:00954 ! crosslinked residues with loss of water is_a: MOD:01993 ! beta-carbon thioether crosslinked residues [Term] id: MOD:01982 name: N,N,N-trimethylglycine def: "modification from RESID" [ChEBI:17750, PubMed:23818633, PubMed:23978223, RESID:AA0619] subset: PSI-MOD-slim synonym: "(trimethylammonio)ethanoic acid" EXACT RESID-alternate [] synonym: "1-carboxy-N,N,N-trimethylmethanazanium" EXACT RESID-alternate [] synonym: "2-trimethylammonioacetate" EXACT RESID-alternate [] synonym: "betaine" EXACT RESID-alternate [] synonym: "carboxy-N,N,N-trimethylmethanaminium" EXACT RESID-systematic [] synonym: "carboxymethyl-trimethylazanium" EXACT RESID-alternate [] synonym: "glycine betaine" EXACT RESID-alternate [] synonym: "MOD_RES N,N,N-trimethylglycine" EXACT UniProt-feature [] synonym: "N,N,N-trimethylglycine cation" EXACT RESID-alternate [] synonym: "N,N,N-trimethylglycinium" EXACT RESID-alternate [] synonym: "N2Me3+Gly" EXACT PSI-MOD-label [] xref: DiffAvg: "43.09" xref: DiffFormula: "C 3 H 7 N 0 O 0" xref: DiffMono: "43.054775" xref: Formula: "C 5 H 11 N 1 O 1" xref: MassAvg: "101.15" xref: MassMono: "101.084064" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00714 ! methylated glycine is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue [Term] id: MOD:01983 name: N,N-dimethylglycine def: "A protein modification that effectively converts a glycine residue to N,N-dimethyllglycine." [ChEBI:17724, PubMed:23818633, PubMed:23978223, RESID:AA0620] synonym: "(dimethylamino)ethanoic acid" EXACT RESID-systematic [] synonym: "1-carboxy-N,N-dimethylaminomethane" EXACT RESID-alternate [] synonym: "2-(dimethylamino)acetic acid" EXACT RESID-alternate [] synonym: "MOD_RES N,N-dimethylglycine" EXACT UniProt-feature [] synonym: "vitamin B16" EXACT RESID-alternate [] xref: DiffAvg: "28.05" xref: DiffFormula: "C 2 H 4 N 0 O 0" xref: DiffMono: "28.031300" xref: Formula: "C 4 H 8 N 1 O 1" xref: MassAvg: "86.11" xref: MassMono: "86.060589" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00714 ! methylated glycine is_a: MOD:01686 ! alpha-amino dimethylated residue [Term] id: MOD:01984 name: 2-(L-cystein-S-yl)-L-alanine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-alanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-alanine." [PubMed:21526839, RESID:AA0621] comment: Cross-link 2. synonym: "(2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic [] synonym: "(2R,5R)-2,5-diamino-5-methyl-4-thiahexanedioic acid" EXACT RESID-alternate [] synonym: "alpha-(L-cystein-S-yl)-L-alanine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 6 H 8 N 2 O 2 S 1" xref: MassAvg: "172.20" xref: MassMono: "172.030649" xref: Origin: "A, C" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00901 ! modified L-alanine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:01985 name: 2-(L-cystein-S-yl)-D-asparagine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-asparagine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-asparagine." [PubMed:21786372, RESID:AA0622] comment: Cross-link 2. synonym: "(2S)-2,4-diamino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-4-oxobutanoic acid" EXACT RESID-systematic [] synonym: "alpha-(L-cystein-S-yl)-D-asparagine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 7 H 9 N 3 O 3 S 1" xref: MassAvg: "215.23" xref: MassMono: "215.036462" xref: Origin: "C, N" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00903 ! modified L-asparagine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:01986 name: 2-(L-cystein-S-yl)-L-serine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-serine." [PubMed:21526839, RESID:AA0623] comment: Cross-link 2. synonym: "(2R)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid" EXACT RESID-systematic [] synonym: "(2R,5R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 6 H 8 N 2 O 3 S 1" xref: MassAvg: "188.20" xref: MassMono: "188.025563" xref: Origin: "C, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:01987 name: 2-(L-cystein-S-yl)-D-serine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-serine." [PubMed:21786372, RESID:AA0624] comment: Cross-link 2. synonym: "(2R,5S)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid" EXACT RESID-alternate [] synonym: "(2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid" EXACT RESID-systematic [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 6 H 8 N 2 O 3 S 1" xref: MassAvg: "188.20" xref: MassMono: "188.025563" xref: Origin: "C, S" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00916 ! modified L-serine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:01988 name: 2-(L-cystein-S-yl)-L-threonine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-threonine." [PubMed:21526839, RESID:AA0625] comment: Cross-link 2. synonym: "(2R,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic [] synonym: "(2R,5R,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid" EXACT RESID-alternate [] synonym: "alpha-(L-cystein-S-yl)-L-threonine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 7 H 10 N 2 O 3 S 1" xref: MassAvg: "202.23" xref: MassMono: "202.041213" xref: Origin: "C, T" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00917 ! modified L-threonine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:01989 name: 2-(L-cystein-S-yl)-D-tyrosine def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-tyrosine." [PubMed:21526839, RESID:AA0626] comment: Cross-link 2. synonym: "(2R,5S)-2,5-diamino-5-carboxyl-6-(hydroxyphenyl)-4-thiahexanoic acid" EXACT RESID-alternate [] synonym: "(2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic [] synonym: "alpha-(L-cystein-S-yl)-D-tyrosine" EXACT RESID-alternate [] xref: DiffAvg: "-2.02" xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0" xref: DiffMono: "-2.015650" xref: Formula: "C 12 H 12 N 2 O 3 S 1" xref: MassAvg: "264.30" xref: MassMono: "264.056863" xref: Origin: "C, Y" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00664 ! stereoisomerized residue is_a: MOD:00919 ! modified L-tyrosine residue is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues [Term] id: MOD:01990 name: protonated glycine (glycinium) residue def: "A protein modification that effectively converts a glycine residue to a glycinium (protonated glycine)." [ChEBI:64723, PubMed:18688235] subset: PSI-MOD-slim xref: DiffAvg: "1.01" xref: DiffFormula: "C 0 H 1 N 0 O 0" xref: DiffMono: "1.007276" xref: FormalCharge: "1+" xref: Formula: "C 2 H 5 N 1 O 1" xref: MassAvg: "59.07" xref: MassMono: "59.036565" xref: Origin: "G" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:00908 ! modified glycine residue is_a: MOD:01700 ! alpha-amino protonated residue [Term] id: MOD:01991 name: N,N,N-trimethylglycine (from glycinium) def: "A protein modification that effectively converts a glycinium (protonated glycine) residue to an N,N,N-trimethylglycine." [ChEBI:17750, PubMed:23818633, PubMed:23978223, RESID:AA0619] comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Gly process (MOD:01982) accounts for both protonation and trimethylation. subset: PSI-MOD-slim synonym: "N2Me3Gly" EXACT PSI-MOD-label [] xref: DiffAvg: "42.08" xref: DiffFormula: "C 3 H 6 N 0 O 0" xref: DiffMono: "42.046402" xref: FormalCharge: "1+" xref: Formula: "C 5 H 11 N 1 O 1" xref: MassAvg: "101.15" xref: MassMono: "101.083515" xref: Origin: "MOD:01990" xref: Source: "natural" xref: TermSpec: "N-term" is_a: MOD:01687 ! alpha-amino trimethylated residue relationship: derives_from MOD:01990 ! protonated glycine (glycinium) residue [Term] id: MOD:01992 name: alpha-carbon thioether crosslinked residues def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the alpha-carbon of another amino acid residue." [PubMed:18688235] is_a: MOD:00687 ! thioether crosslinked residues [Term] id: MOD:01993 name: beta-carbon thioether crosslinked residues def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the beta-carbon of another amino acid residue." [PubMed:18688235] comment: These are typical lanthionine-like crosslinks. is_a: MOD:00687 ! thioether crosslinked residues [Term] id: MOD:01994 name: N1'-formyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to N1'-formyl-L-tryptophan." [PubMed:18688235] comment: This modifications has not been reported as commonly encountered [JSG]. synonym: "N1'FoTrp" EXACT PSI-MOD-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 12 H 10 N 2 O 2" xref: MassAvg: "214.22" xref: MassMono: "214.074228" xref: Origin: "W" xref: Source: "hypothetical" xref: TermSpec: "none" is_a: MOD:01106 ! N-formyl-L-tryptophan [Term] id: MOD:01995 name: N2-formyl-L-tryptophan def: "A protein modification that effectively converts an L-tryptophan residue to N2-formyl-L-tryptophan." [PubMed:18688235] comment: This modifications has not been reported as commonly encountered [JSG]. synonym: "N2FoTrp" EXACT PSI-MOD-label [] xref: DiffAvg: "28.01" xref: DiffFormula: "C 1 H 0 N 0 O 1" xref: DiffMono: "27.994915" xref: Formula: "C 12 H 11 N 2 O 2" xref: MassAvg: "215.23" xref: MassMono: "215.082053" xref: Origin: "W" xref: Source: "hypothetical" xref: TermSpec: "N-term" is_a: MOD:01106 ! N-formyl-L-tryptophan [Term] id: MOD:01996 name: butanoylated residue def: "A protein modification that effectively replaces a hydrogen atom with an butanoyl group." [PubMed:18688235] comment: Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). synonym: "ButRes" EXACT PSI-MOD-label [] synonym: "Butyryl" RELATED UniMod-interim [] synonym: "butyrylation" EXACT PSI-MOD-alternate [] xref: DiffAvg: "70.09" xref: DiffFormula: "C 4 H 6 O 1" xref: DiffMono: "70.041865" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:00649 ! acylated residue [Term] id: MOD:01997 name: N-butanoylated residue def: "A protein modification that effectively replaces a residue amino or imino hydrogen with a butanoyl group." [PubMed:18688235] synonym: "N-butanoyl" EXACT PSI-MOD-alternate [] synonym: "N-butanoylation" EXACT PSI-MOD-alternate [] synonym: "N-butyryl" EXACT PSI-MOD-alternate [] synonym: "N-butyrylation" EXACT PSI-MOD-alternate [] synonym: "NButRes" EXACT PSI-MOD-label [] xref: DiffAvg: "70.09" xref: DiffFormula: "C 4 H 6 N 0 O 1" xref: DiffMono: "70.041865" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "none" xref: TermSpec: "none" is_a: MOD:01996 ! butanoylated residue [Term] id: MOD:01998 name: alpha-amino butanoylated residue def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a butanoyl group." [PubMed:18688235] synonym: "N2ButRes" EXACT PSI-MOD-label [] xref: DiffAvg: "70.09" xref: DiffFormula: "C 4 H 6 N 0 O 1" xref: DiffMono: "70.041865" xref: Formula: "none" xref: MassAvg: "none" xref: MassMono: "none" xref: Origin: "X" xref: Source: "artifact" xref: TermSpec: "N-term" is_a: MOD:01997 ! N-butanoylated residue [Term] id: MOD:01999 name: N6-(11-cis)-retinylidene-L-lysine def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-(11-cis)-L-lysine." [PubMed:18688235] synonym: "(2S)-2-amino-6-[(2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT PSI-MOD-alternate [] xref: DiffAvg: "266.43" xref: DiffFormula: "C 20 H 26 N 0 O 0" xref: DiffMono: "266.203451" xref: Formula: "C 26 H 38 N 2 O 1" xref: MassAvg: "394.60" xref: MassMono: "394.298414" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:02000 ! N6-retinylidene-L-lysine (unspecified geometric isomer) [Term] id: MOD:02000 name: N6-retinylidene-L-lysine (unspecified geometric isomer) def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine (unspecified geometric isomer)." [PubMed:18688235] synonym: "(2S)-2-amino-6-[3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT PSI-MOD-alternate [] xref: DiffAvg: "266.43" xref: DiffFormula: "C 20 H 26 N 0 O 0" xref: DiffMono: "266.203451" xref: Formula: "C 26 H 38 N 2 O 1" xref: MassAvg: "394.60" xref: MassMono: "394.298414" xref: Origin: "K" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00912 ! modified L-lysine residue [Typedef] id: contains name: contains def: "'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'." [PubMed:18688235] comment: The inverse relationship to "part of". is_transitive: true [Typedef] id: derives_from name: derives from def: "'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'." [PubMed:18688235] is_transitive: true [Typedef] id: has_functional_parent name: has functional parent def: "'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification." [PubMed:18688235] comment: This relationship indicates that the formula and mass of the child are not inherited from the mass of the parent. is_transitive: true [Typedef] id: part_of name: part of def: "'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'." [PubMed:18688235] is_transitive: true