PRotein Ontology (PRO) Release 53.0, version 0 27-Jul-2017 The Protein Ontology Consortium--Protein Information Resource, The Jackson Laboratory, Reactome, and the Department of Philosophy at the State University of New York at Buffalo--is pleased to announce PRO Release 53.0 (27-Jul-2017). PRO describes the relationships of proteins and protein evolutionary classes, delineates the multiple protein forms of a gene locus (ontology for protein forms), protein complexes, and interconnects existing ontologies. Further information is available at http://www.proteininformationresource.org/pro/. In PRO Release 53.0, version 0: There are 214247 PRO terms in the Protein Ontology. Those representing individual proteins are mapped to 130368 UniProtKB sequences. 59 terms are in the 'external' category. 158 terms are in the 'organism-seqgroup' category. 402 terms are in the 'family' category. 23561 terms are in the 'gene' category. 8331 terms are in the 'sequence' category. 5064 terms are in the 'modification' category. 214 terms are in the 'complex' category. 22 terms are in the 'organism-family' category. 97650 terms are in the 'organism-gene' category. 69720 terms are in the 'organism-sequence' category. 6546 terms are in the 'organism-modification' category. 386 terms are in the 'organism-complex' category. 58 terms are in the 'union' category. 2526 terms have some kind of annotation, codifying the information from 1689 papers. 4445 connections to GO (1723 PRO terms). 292 connections to MOD (255 PRO terms). 616 connections to Pfam (369 PRO terms). 338 connections to SO (317 PRO terms). 349 annotations of a phenotype (342 PRO terms). The ontology includes a subset of terms from external ontologies (such as GO, MOD, and CHEBI) that are used for logical definitions. _Current changes_ 1) Added EnsemblBacteria as a source for gene information. _Forthcoming changes_ 1) Araport will replace TAIR as the authoritative source for Arabidopsis thaliana gene information. The change will take place with release 54.0.