PRotein Ontology (PRO) Release 48.0, version 0 21-January-2016 The Protein Ontology Consortium--Protein Information Resource, The Jackson Laboratory, Reactome, and the Department of Philosophy at the State University of New York at Buffalo--is pleased to announce PRO Release 48.0 (21-January-2016). PRO describes the relationships of proteins and protein evolutionary classes, delineates the multiple protein forms of a gene locus (ontology for protein forms), protein complexes, and interconnects existing ontologies. Further information is available at http://pir.georgetown.edu/pro/. In PRO Release 48.0, version 0: There are 203034 PRO terms in the Protein Ontology. Those representing individual proteins are mapped to 126886 UniProtKB sequences. 55 terms are in the 'external' category. 410 terms are in the 'family' category. 23562 terms are in the 'gene' category. 8319 terms are in the 'sequence' category. 6668 terms are in the 'modification' category. 212 terms are in the 'complex' category. 28 terms are in the 'organism-family' category. 92752 terms are in the 'organism-gene' category. 68055 terms are in the 'organism-sequence' category. 2197 terms are in the 'organism-modification' category. 369 terms are in the 'organism-complex' category. 122 terms are in the 'union' category. 2516 terms have some kind of annotation, codifying the information from 1672 papers. 4442 connections to GO (1709 PRO terms). 292 connections to MOD (255 PRO terms). 620 connections to Pfam (373 PRO terms). 338 connections to SO (317 PRO terms). 349 annotations of a phenotype (342 PRO terms). The ontology includes a subset of terms from GO, MOD, CHEBI, and SO ontologies that are used for logical definitions. If using OBO Edit to view PRO, please turn on the reasoner in order to display the hierarchy. _Current changes_ None _Forthcoming changes_ 1) Continue to add shorthand labels to terms. 2) Resolve names and synonym duplicates. ================================================