PRotein Ontology (PRO) Release 47.0, version 0
25-September-2015

The Protein Ontology Consortium--Protein Information Resource, The Jackson Laboratory, Reactome, and the Department of Philosophy at the State University of New York at Buffalo--is pleased to announce PRO Release 47.0 (25 September 2015). PRO describes the relationships of proteins and protein evolutionary classes, delineates the multiple protein forms of a gene locus (ontology for protein forms), protein complexes, and interconnects existing ontologies. Further information is available at http://pir.georgetown.edu/pro/.

In PRO Release 47.0, version 0:

There are 201287 PRO terms in the pro_full.obo file. Those representing individual proteins are mapped to 120487 UniProtKB sequences.
      54 terms are in the 'external' category.
     406 terms are in the 'family' category.
   23563 terms are in the 'gene' category.
    8319 terms are in the 'sequence' category.
    6665 terms are in the 'modification' category.
     215 terms are in the 'complex' category.
      29 terms are in the 'organism-family' category.
   91446 terms are in the 'organism-gene' category.
   67728 terms are in the 'organism-sequence' category.
    2139 terms are in the 'organism-modification' category.
     374 terms are in the 'organism-complex' category.
     104 terms are in the 'union' category.
2513 terms have some kind of annotation, codifying the information from 1672 papers.
    4439 connections to GO (1706 PRO terms).
     292 connections to MOD (255 PRO terms).
     620 connections to Pfam (373 PRO terms).
     338 connections to SO (317 PRO terms).
     349 annotations of a phenotype (342 PRO terms).

The ontology includes a subset of terms from GO, MOD, CHEBI, and SO ontologies that are used for logical definitions. If using OBO Edit to view PRO, please turn on the reasoner in order to display the hierarchy.

_Current changes_

1) The format for the PAF file has changed. Columns number 15 (Protein_region) and 16 (Modified_residue(s), MOD_ID) in Release 46 have been removed, as all the information about the region and modification are now contained in the ontology file. 

_Forthcoming changes_

1) Continue to add shorthand labels to terms.

2) Resolve names and synonym duplicates.




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