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PRotein Ontology (PRO) Release 27.0, version 0
25-April-2012

The Protein Ontology Consortium--Protein Information Resource, The Jackson Laboratory, Reactome, and the Department of Philosophy at the State University of New York at Buffalo--is pleased to announce PRO Release 27.0 (25-April-2012). PRO describes the relationships of proteins and protein evolutionary classes, delineates the multiple protein forms of a gene locus (ontology for protein forms), protein complexes, and interconnects existing ontologies. Further information is available at http://pir.georgetown.edu/pro/.

In PRO Release 27.0, version 0:

There are 28555 PRO terms
     314 terms are in the 'family' category.
   18274 terms are in the 'gene' category.
    1471 terms are in the 'sequence' category.
    6139 terms are in the 'modification' category.
     125 terms are in the 'complex' category.
       4 terms are in the 'organism-family' category.
     868 terms are in the 'organism-gene' category.
     518 terms are in the 'organism-sequence' category.
     485 terms are in the 'organism-modification' category.
     233 terms are in the 'organism-complex' category.
      12 terms are in the 'union' category.
1648 terms have some kind of annotation, codifying the information from 1161 papers.
    2410 connections to GO (840 PRO terms).
     374 connections to MOD (327 PRO terms).
     604 connections to Pfam (361 PRO terms).
     338 connections to SO (317 PRO terms).
     344 annotations of a phenotype (337 PRO terms).

The ontology includes a subset of terms from GO, MOD, CHEBI, and SO ontologies that are used for logical definitions.  If using OBO Edit to view PRO, please turn on the reasoner in order to display the hierarchy.


_Current changes_

1) Nearly 2200 additional terms have short labels applied. Short labels were added to many specific modified forms (of the type "XXX phophorylated 1").
2) Over 60000 additional UniProtKB mappings have been added to the promapping files. The additional mapped accessions are predominantly from the model organisms rat, chicken, fruit fly, zebrafish, A. thaliana, S. Pombe, S. cerevisiae, C. elegans, and D. Discoideum, joining the previous mapped set from human, mouse, and E. coli. Many thanks to Paul Thomas for providing Panther data used to do the mapping! 

_Forthcoming changes_

1) Continue to add shorthand labels to terms.
2) Continue to expand the set of mapped terms.
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