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PRotein Ontology (PRO) Release 14.0, version 0
14-November-2010

The Protein Ontology Consortium--Protein Information Resource, The Jackson Laboratory, Reactome, and the Department of Philosophy at the State University of New York at Buffalo--is pleased to announce PRO Release 14.0 (21-November-2010). PRO describes the relationships of proteins and protein evolutionary classes, delineates the multiple protein forms of a gene locus (ontology for protein forms), protein complexes, and interconnects existing ontologies. Further information is available at http://pir.georgetown.edu/pro/.

In PRO Release 14.0, version 0:

There are 25948 PRO terms
   298 terms are in the 'family' category.
   18196 terms are in the 'gene' category.
   1186 terms are in the 'sequence' category.
   5687 terms are in the 'modification' category.
   165 terms are in the 'organism-gene' category.
   154 terms are in the 'organism-sequence' category.
   88 terms are in the 'organism-modification' category.
   35 terms are in the 'complex' category.
   36 terms are in the 'organism-complex' category.
1491 terms have some kind of annotation, codifying the information from 965 papers.
  2102 connections to GO (730 PRO terms).
  374 connections to MOD (327 PRO terms).
  604 connections to Pfam (362 PRO terms).
  325 connections to SO (307 PRO terms).
  296 annotations of a phenotype (289 PRO terms).

The ontology includes a subset of terms from GO, MOD, CHEBI, and SO ontologies that are used for logical definitions.  If using OBO Edit to view PRO, please turn on the reasoner in order to display the hierarchy.

_Changes from Release 13.0_

1) PRO will supply a second file for each current file. The second file will contain a '_pr' (for example, pro_pr.obo or PAF_pr.txt) to indicate that the file uses the forthcoming PR: ID space (see below).

_Future changes_

1) PRO identifier will change from PRO: to PR:
Effective with release 16.0 (barring unforeseen delays) the PRO ID space will change from PRO: to PR: to avoid clashing with UniProtKB feature identifiers indicating processed protein subsequences (PRO_).

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