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PRotein Ontology (PRO) Release 10.0, version 0
08-April-2010

The Protein Ontology Consortium--Protein Information Resource, The Jackson Laboratory, Reactome, and the Department of Philosophy at the
State University of New York at Buffalo--is pleased to announce PRO Release 10.0 (08-April-2010). PRO describes the relationships of proteins and protein evolutionary classes, delineates the multiple protein forms of a gene locus (ontology for protein forms), and interconnects existing ontologies. Further information is available at http://pir.georgetown.edu/pro/.

In PRO Release 10.0, version 0:

There are 25358 PRO terms
   1 terms are in the 'organism-modification' category.
   5 terms are in the 'organism-sequence' category.
   1083 terms are in the 'sequence' category.
   7 terms are in the 'complex' category.
   18171 terms are in the 'gene' category.
   5586 terms are in the 'modification' category.
   128 terms are in the 'organism-gene' category.
   276 terms are in the 'family' category.
1394 terms have some kind of annotation, codifying the information from 897 papers.
  1931 connections to GO (654 PRO terms).
  358 connections to MOD (315 PRO terms).
  599 connections to Pfam (358 PRO terms).
  325 connections to SO (307 PRO terms).
  296 annotations of a phenotype (289 PRO terms).

The ontology includes a subset of terms from MOD, MI, and SO ontologies that are used for logical definitions.  If using OBO Edit to view PRO, please turn on the reasoner in order to display the hierarchy.

_Changes from Release 9.0_

1) The PRO term for signal peptide (PRO:000021936) has been replaced by the SO term for signal_peptide (SO:0000418).

2) The PRO term for "broken protein peptide bond" has been made obsolete.  All cleaved forms (other than signal peptide removed and initiator methionine removed forms) are now defined in terms of "proteolytic cleavage product" (PRO:000018264).

3) We have added some terms for protein containing complexes. These are children of GO:0032991 macromolecular complex. The protein complex ontology does not overlap with GO cellular component, but use GO as the parent term and describes more specific complexes.

4) The category=complex has been added to the PRO protein complex terms.

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